Aliases for CLEC9A Gene
External Ids for CLEC9A Gene
Previous GeneCards Identifiers for CLEC9A Gene
CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]
GeneCards Summary for CLEC9A Gene
CLEC9A (C-Type Lectin Domain Containing 9A) is a Protein Coding gene. Among its related pathways are Dendritic Cells Developmental Lineage Pathway. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC12B.
UniProtKB/Swiss-Prot for CLEC9A Gene
Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.