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Aliases for CLEC9A Gene

Aliases for CLEC9A Gene

  • C-Type Lectin Domain Family 9, Member A 2 3
  • DNGR1 3 6
  • C-Type Lectin Domain Family 9 Member A 3
  • HEEE9341 3
  • UNQ9341 3

External Ids for CLEC9A Gene

Previous GeneCards Identifiers for CLEC9A Gene

  • GC12P010075
  • GC12P010183
  • GC12P009926

Summaries for CLEC9A Gene

Entrez Gene Summary for CLEC9A Gene

  • CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]

GeneCards Summary for CLEC9A Gene

CLEC9A (C-Type Lectin Domain Family 9, Member A) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC7A.

UniProtKB/Swiss-Prot for CLEC9A Gene

  • Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC9A Gene

Genomics for CLEC9A Gene

Regulatory Elements for CLEC9A Gene

Genomic Location for CLEC9A Gene

Start:
10,030,677 bp from pter
End:
10,066,027 bp from pter
Size:
35,351 bases
Orientation:
Plus strand

Genomic View for CLEC9A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC9A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC9A Gene

Proteins for CLEC9A Gene

  • Protein details for CLEC9A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXN8-CLC9A_HUMAN
    Recommended name:
    C-type lectin domain family 9 member A
    Protein Accession:
    Q6UXN8
    Secondary Accessions:
    • B0ZBM2

    Protein attributes for CLEC9A Gene

    Size:
    241 amino acids
    Molecular mass:
    27324 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for CLEC9A Gene

neXtProt entry for CLEC9A Gene

Proteomics data for CLEC9A Gene at MOPED

Post-translational modifications for CLEC9A Gene

Other Protein References for CLEC9A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLEC9A Gene

Domains for CLEC9A Gene

Gene Families for CLEC9A Gene

HGNC:
  • CLEC :C-type lectin domain containing

Protein Domains for CLEC9A Gene

Suggested Antigen Peptide Sequences for CLEC9A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXN8

UniProtKB/Swiss-Prot:

CLC9A_HUMAN :
  • Q6UXN8
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC9A: view

Function for CLEC9A Gene

Molecular function for CLEC9A Gene

UniProtKB/Swiss-Prot Function: Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.

Gene Ontology (GO) - Molecular Function for CLEC9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC9A: view

Phenotypes for CLEC9A Gene

genes like me logo Genes that share phenotypes with CLEC9A: view

Animal Models for CLEC9A Gene

MGI Knock Outs for CLEC9A:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CLEC9A Gene

Localization for CLEC9A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC9A Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC9A Gene COMPARTMENTS Subcellular localization image for CLEC9A gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CLEC9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IDA 18408006
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC9A: view

Pathways for CLEC9A Gene

SuperPathways for CLEC9A Gene

No Data Available

Interacting Proteins for CLEC9A Gene

Gene Ontology (GO) - Biological Process for CLEC9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IDA 18408006
GO:0050715 positive regulation of cytokine secretion IDA 18408006
genes like me logo Genes that share ontologies with CLEC9A: view

No data available for Pathways by source for CLEC9A Gene

Transcripts for CLEC9A Gene

mRNA/cDNA for CLEC9A Gene

(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC9A Gene

C-type lectin domain family 9, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC9A Gene

No ASD Table

Relevant External Links for CLEC9A Gene

GeneLoc Exon Structure for
CLEC9A
ECgene alternative splicing isoforms for
CLEC9A

Expression for CLEC9A Gene

mRNA expression in normal human tissues for CLEC9A Gene

mRNA differential expression in normal tissues according to GTEx for CLEC9A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (9.1), Brain - Substantia nigra (5.8), Brain - Hypothalamus (4.2), and Testis (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CLEC9A Gene

SOURCE GeneReport for Unigene cluster for CLEC9A Gene Hs.531189

mRNA Expression by UniProt/SwissProt for CLEC9A Gene

Q6UXN8-CLC9A_HUMAN
Tissue specificity: In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.
genes like me logo Genes that share expressions with CLEC9A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CLEC9A Gene

Orthologs for CLEC9A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC9A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC9A 35
  • 99.17 (n)
  • 98.76 (a)
CLEC9A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLEC9A 36
  • 63 (a)
OneToOne
LOC616060 35
  • 79.67 (n)
  • 70.95 (a)
dog
(Canis familiaris)
Mammalia CLEC9A 35
  • 81.39 (n)
  • 71.67 (a)
CLEC9A 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec9a 35
  • 71.99 (n)
  • 60.08 (a)
Clec9a 16
Clec9a 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLEC9A 36
  • 32 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clec9a 35
  • 74 (n)
  • 60.17 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
OneToMany
Species with no ortholog for CLEC9A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC9A Gene

ENSEMBL:
Gene Tree for CLEC9A (if available)
TreeFam:
Gene Tree for CLEC9A (if available)

Paralogs for CLEC9A Gene

Paralogs for CLEC9A Gene

Selected SIMAP similar genes for CLEC9A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLEC9A: view

Variants for CLEC9A Gene

Sequence variations from dbSNP and Humsavar for CLEC9A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs874463 -- 10,066,112(+) ACGAA(A/T)TTCCA downstream-variant-500B
rs1010981 -- 10,061,719(+) CTTTT(A/G)CGATG intron-variant
rs1074059 -- 10,049,179(+) AGTTC(C/T)CAACA intron-variant
rs1074060 -- 10,049,629(+) CCTCT(A/G)CTAGC intron-variant
rs1488816 -- 10,051,327(+) tgaac(A/G)catta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC9A Gene

Variant ID Type Subtype PubMed ID
nsv898755 CNV Loss 21882294
esv9698 OTHER Inversion 19470904
nsv524870 CNV Gain 19592680

Relevant External Links for CLEC9A Gene

HapMap Linkage Disequilibrium report
CLEC9A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC9A Gene

Disorders for CLEC9A Gene

Relevant External Links for CLEC9A

Genetic Association Database (GAD)
CLEC9A
genes like me logo Genes that share disorders with CLEC9A: view

No data available for UniProtKB/Swiss-Prot for CLEC9A Gene

Publications for CLEC9A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes. (PMID: 18408006) Huysamen C. … Brown G.D. (J. Biol. Chem. 2008) 3 4
  3. Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. (PMID: 18497879) Sancho D. … Reis e Sousa C. (J. Clin. Invest. 2008) 3 4
  4. The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. (PMID: 22483802) Zhang J.G. … Lahoud M.H. (Immunity 2012) 3 4
  5. Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease. (PMID: 24049150) Kassianos A.J. … Wilkinson R. (Am. J. Physiol. Renal Physiol. 2013) 3

Products for CLEC9A Gene

Sources for CLEC9A Gene

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