CLEC7A Gene
protein-coding GIFtS: 57
GCID: GC12M010269
|
|
C-type lectin domain family 7, member A(Previous names: C-type (calcium dependent, carbohydrate-recognition domain)...)
(Previous symbol: CLECSF12)
| |
Aliases
for CLEC7A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| C-Type Lectin Domain Family 7, Member A1 2 | | C-Type Lectin Superfamily Member 122 3 | | CLECSF121 2 3 5 | | DC-Associated C-Type Lectin 12 3 | | DECTIN12 3 5 | | CANDF42 5 | | C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, SuperfamilyMember 121 2 | | HDectin-11 | | Dectin-13 | | C-Type Lectin Domain Family 7 Member A2 | | Beta-Glucan Receptor2 3 | | Dendritic Cell-Associated C-Type Lectin-12 | | Dendritic Cell-Associated C-Type Lectin 12 3 | | Lectin-Like Receptor 12 | | BGR2 3 | | Dectin-13 |
Export aliases for CLEC7A gene to outside databasesPrevious GC identifers: GC12M010161 GC12M010012 |
Summaries
for CLEC7A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CLEC7A:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encodedglycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and acytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognitionreceptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in thisway plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms,have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in thenatural killer gene complex region. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CLC7A_HUMAN, Q9BXN2Function: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such ascell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response andfor TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediatesproduction of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a waythat does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (Bysimilarity)
Gene Wiki entry for CLEC7A
|
Genomic Views
for CLEC7A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLEC7A gene promoter:
Nkx3-1 Nkx3-1 v4 AML1a GATA-3 FOXD3 Nkx3-1 v1 GATA-2 GATA-1 Nkx3-1 v2 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLEC7A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC7A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.2 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13.2-p12.3CLEC7A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M010269: view genomic region
(about GC identifiers)
Start:
|
10,269,376 bp from pter |
End:
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10,282,868 bp from pter |
Size:
|
13,493 bases |
Orientation:
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minus strand |
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Proteins
for CLEC7A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLC7A_HUMAN, Q9BXN2 (See
protein sequence)Recommended Name: C-type lectin domain family 7 member A Size: 247 amino acids; 27627 Da
Subunit: Homodimer (By similarity). Interacts with SYK; participates in leukocyte activation in presence of fungalpathogens (By similarity). Isoform 5 interacts with RANBP9
Subcellular location: Cell membrane; Single-pass type II membrane protein
Subcellular location: Isoform 5: Cytoplasm
Subcellular location: Isoform 6: Cytoplasm (Probable)
Subcellular location: Isoform 7: Cytoplasm (Probable)
Secondary accessions: B2R861 B7Z494 B7Z5A9 B7Z5B9 Q6IPS7 Q96D32 Q96DR9 Q96LD3 Q96PA5 Q96PA6 Q96PA7Q96PA8 Q9H1K3Alternative splicing: 9 isoforms: Q9BXN2-1 Q9BXN2-2 Q9BXN2-3 Q9BXN2-4 Q9BXN2-5 Q9BXN2-6 Q9BXN2-7 Q9BXN2-8 Q9BXN2-9 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CLEC7A: NX_Q9BXN2
Post-translational modifications:
Phosphorylated on tyrosine residues in response to glucan binding (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXN2
CLEC7A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_072092.2 NP_922938.1 NP_922939.1 NP_922940.1 NP_922941.1 NP_922945.1
ENSEMBL proteins: ENSP00000266456 ENSP00000432876 ENSP00000298523 ENSP00000379743 ENSP00000302569 ENSP00000436923 ENSP00000344723 ENSP00000431461 ENSP00000434392 ENSP00000312089 ENSP00000434954
Human Recombinant Protein Products for CLEC7A:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CLEC7A for ontologies About GeneDecksing
CLEC7A Antibody Products:
Assay Products for CLEC7A: |
Protein
Domains /
Families
for CLEC7A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLEC7A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BXN2ProtoNet protein and cluster: Q9BXN2 1 Blocks protein family: IPB013600 Ly49-like N-terminal
UniProtKB/Swiss-Prot: CLC7A_HUMAN, Q9BXN2Similarity: Contains 1 C-type lectin domain |
Function
for CLEC7A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CLC7A_HUMAN, Q9BXN2Function: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such ascell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response andfor TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediatesproduction of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a waythat does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (Bysimilarity)Induction: Up-regulated during differentiation from monocytes into dendritic cells Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
CLEC7A for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for CLEC7A:
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Clec7a):
CLEC7A for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for CLEC7A: Clec7atm1Gdb Clec7atm1Yiw
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC7A (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC7A (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): CLEC7A (NM_197948) | |  | Sino Biological Human cDNA Clone for CLEC7A | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLEC7A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC7A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC7A |
|
Pathways & Interactions
for CLEC7A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Tuberculosis | | | 2 | Phagosome | | | 3 | NF-kappaB Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for CLEC7A
2 
Kegg Pathways (Kegg details for CLEC7A):
CLEC7A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC7A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/12 Interacting proteins for CLEC7A (Q9BXN23 ENSP000003025694) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001878 | response to yeast |
-- | -- | | GO:0001879 | detection of yeast |
-- | -- | | GO:0002221 | pattern recognition receptor signaling pathway |
IDA | 11567029 | | GO:0002238 | response to molecule of fungal origin |
-- | -- | | GO:0002752 | cell surface pattern recognition receptor signaling pathway |
-- | -- |
CLEC7A for ontologies About GeneDecksing
|
Drugs & Compounds
for CLEC7A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CLEC7A for compounds About GeneDecksing
 Browse Tocris compounds for CLEC7A
6 Novoseek chemical compound relationships for CLEC7A gene About this table
Search CenterWatch for drugs/clinical trials and news about CLEC7A / CLC7A
|
Transcripts
for CLEC7A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLEC7A gene (9 alternative transcripts): NM_022570.4 NM_197947.2 NM_197948.2 NM_197949.2 NM_197950.2 NM_197954.2 NM_197951.1 NM_197952.1 NM_197953.1 Unigene Cluster for CLEC7A: C-type lectin domain family 7, member A Hs.143929 [show with all ESTs]Unigene Representative Sequence: NM_19794713 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000353231 ENST00000534609(uc001qxf.2 uc001qxg.2 uc001qxh.2 uc001qxi.2 uc001qxj.2 uc001qxk.1 uc001qxn.3)
ENST00000529761(uc001qxe.3) ENST00000298523 ENST00000396484(uc009zhg.1)
ENST00000304084 ENST00000465100 ENST00000349926 ENST00000533022 ENST00000531192(uc021qva.1)
ENST00000528799(uc021quz.1) ENST00000310002 ENST00000525605
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC7A (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC7A (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): CLEC7A (NM_197948) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLEC7A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC7A |
Additional cDNA sequence: AF313468.1 AF313469.1 AF400595.1 AF400596.1 AF400597.1 AF400598.1 AF400599.1 AJ312372.1 AJ312373.1 AK294111.1 AK295108.1 AK297028.1 AK298679.1 AK298724.1 AK313247.1 AY009090.2 AY026769.2 AY026770.2 AY026771.1 AY359002.1 BC013385.1 BC071746.1 BC093829.1 BC093831.1 10 DOTS entries: DT.430109 DT.92039763 DT.100815542 DT.101965064 DT.95272729 DT.95272734 DT.97838632 DT.40309927 DT.121180571 DT.92419093 24/66 AceView cDNA sequences (see all 66): AJ312373 BM280423 AY026769 NM_197948 AY026770 AY359002 NM_197947 BC013385 AF400601 AI708851 AA535015 NM_197954 NM_197950 NM_197951 BX458753 AF400595 BX479704 AF400597 AF400599 AF400602 AI207390 AI209158 NM_197953 AF400600
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC7A (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for CLEC7A
|
Expression
for CLEC7A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLEC7A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGATTTG
About this image
See CLEC7A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLEC7A
SOURCE GeneReport for Unigene cluster: Hs.143929
UniProtKB/Swiss-Prot: CLC7A_HUMAN, Q9BXN2Tissue specificity: Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bonemarrow, lung, muscle, stomach and placenta
SABiosciences Expression via Pathway-Focused PCR Arrays including CLEC7A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC7A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC7A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC7A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC7A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC7A |
Orthologs
for CLEC7A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CLEC7A gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
CLEC9A6 |
-- |
41(a) |
1 → many |
2(81818136-81823316) |
ENSEMBL Gene Tree for CLEC7A (if available)
TreeFam Gene Tree for CLEC7A (if available) |
Paralogs
for CLEC7A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLEC7A gene
- OLR12 CLEC9A2 KLRC22 ENSG000002558192 CLEC12A2 KLRC32 CLEC1A2 KLRD12
- KLRK12 KLRC42 CLEC1B2 ENSG000002556412 KLRC12 CLEC12B2
6 SIMAP similar genes for CLEC7A using alignment to 1 protein entry: CLC7A_HUMAN:DKFZp686L24211 BGR OLR1 CLEC1B CLEC5A CLECSF5
CLEC7A for paralogs About GeneDecksing
|
Genomic Variants
for CLEC7A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: CLC7A_HUMAN, Q9BXN2Polymorphism: A stop polymorphism at position 238 may be associated with invasive aspergillosis following hematopoieticstem cell transplantation. The risk is highest when the polymorphism is present in both donors and recipients[MIM:614079]
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLEC7A (10269376 - 10282868 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLEC7A: --
Human Gene Mutation Database (HGMD): CLEC7A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC7A |
|
Disorders
/ Diseases
for CLEC7A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLEC7A for disorders About GeneDecksing
OMIM gene information: 606264
OMIM disorders: 613108
UniProtKB/Swiss-Prot: CLC7A_HUMAN, Q9BXN2
Defects in CLEC7A may be a cause of familial candidiasis type 4 (CANDF4) [MIM:613108]. It is a rare disorderwith altered immune responses and impaired clearance of fungal infections, selective against Candida. It ischaracterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms ofthe genus Candida, mainly Candida albicans
17  diseases for CLEC7A: About MalaCardsgraft versus host disease invasive aspergillosis candidiasis haemophilus influenzae
coccidioidomycosis aspergillosis transient arthritis histoplasmosis
eczema rheumatoid arthritis influenza hepatitis b
arthritis tuberculosis hepatitis acute graft versus host disease
mycobacterium tuberculosis
2 diseases from the University of Copenhagen DISEASES database for CLEC7A:Coccidioidomycosis Transient arthritis 3 Novoseek disease relationships for CLEC7A gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
27.9 |
2 |
8751898 (1), 1334474 (1) |
| tumors |
1.3 |
2 |
8751898 (1), 1334474 (1) |
| tuberculosis |
0 |
1 |
2108212 (1) |
Human Genome Epidemiology (HuGE) Navigator: CLEC7A (7 documents)
Export disorders for CLEC7A gene to outside databases
|
Publications
for CLEC7A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLEC7A gene, integrated from 9 sources (see all 111):
(articles sorted by number of sources associating them with CLEC7A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the human beta-glucan receptor and its alternatively spliced isoforms. (PubMed id 11567029)1, 2, 9 Willment J.A.... Brown G.D. (2001)
- Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1. (PubMed id 11470510)1, 2, 9 Yokota K.... Ariizumi K. (2001)
- Dectin-1 Y238X polymorphism associates with susceptib ility to invasive aspergillosis in hematopoietic transplantation through impair ment of both recipient- and donor-dependent mechanisms of antifungal immunity. (PubMed id 20807886)1, 2 Cunha C....Carvalho A. (2010)
- Human dectin-1 deficiency and mucocutaneous fungal in fections. (PubMed id 19864674)1, 2 Ferwerda B....Netea M.G. (2009)
- Human Dectin-1 isoform E is a cytoplasmic protein and interacts with RanBPM. (PubMed id 16870151)1, 2 Xie J.... Gu J. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Molecular and functional characterization of human Dectin-1. (PubMed id 12423684)1, 2 Gruenebach F.... Brossart P. (2002)
- A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. (PubMed id 11745369)1, 2 Sobanov Y.... Hofer E. (2001)
- Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells. (PubMed id 11491532)1, 2 Hermanz-Falcon P.... Fernandez-Ruiz E. (2001)
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External Searches for CLEC7A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CLEC7A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CLEC7A gene
(According to HUGE)
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Specialized Databases showing CLEC7A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for CLEC7A | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for CLEC7A gene:
Search GeneIP for patents involving CLEC7A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CLEC7A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLEC7A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC7A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC7A | | | OriGene Protein Over-expression Lysate for CLEC7A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLEC7A | | OriGene 3'-UTR Clone for CLEC7A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC7A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC7A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLEC7A | | OriGene Custom Protein Services for CLEC7A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLEC7A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC7A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC7A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC7A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC7A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC7A |
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| | Antibodies & Assays for CLEC7A (dectin-1) |
| | | | Search Tocris compounds for CLEC7A |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC7A |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CLEC7A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC7A |
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