Aliases for CLEC7A Gene
- C-Type Lectin Domain Family 7, Member A 2 3
- CLECSF12 3 4 6
- DECTIN1 3 4 6
- C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 12 2 3
- Dendritic Cell-Associated C-Type Lectin 1 3 4
- C-Type Lectin Superfamily Member 12 3 4
- DC-Associated C-Type Lectin 1 3 4
- Beta-Glucan Receptor 3 4
External Ids for CLEC7A Gene
Previous Symbols for CLEC7A Gene
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLEC7A Gene
CLEC7A (C-Type Lectin Domain Family 7, Member A) is a Protein Coding gene. Diseases associated with CLEC7A include transient arthritis and aspergillosis. Among its related pathways are NOD-like Receptor Signaling Pathways and Tuberculosis. GO annotations related to this gene include carbohydrate binding and MHC protein binding. An important paralog of this gene is CLEC12A.
UniProtKB/Swiss-Prot for CLEC7A Gene
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).