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Aliases for CLEC6A Gene

Aliases for CLEC6A Gene

  • C-Type Lectin Domain Family 6 Member A 2 3 5
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 10 2 3
  • Dendritic Cell-Associated C-Type Lectin 2 3 4
  • C-Type Lectin Superfamily Member 10 3 4
  • DC-Associated C-Type Lectin 2 3 4
  • Dectin-2 3 4
  • CLECSF10 3 4
  • C-Type Lectin Domain Family 6, Member A 2
  • Dectin 2 3
  • DECTIN2 4
  • CLEC4N 3

External Ids for CLEC6A Gene

Previous HGNC Symbols for CLEC6A Gene

  • CLECSF10

Previous GeneCards Identifiers for CLEC6A Gene

  • GC12U900496
  • GC12P008499
  • GC12P008608
  • GC12P008391

Summaries for CLEC6A Gene

Entrez Gene Summary for CLEC6A Gene

  • The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for CLEC6A Gene

CLEC6A (C-Type Lectin Domain Family 6 Member A) is a Protein Coding gene. Diseases associated with CLEC6A include Cryptococcosis and Common Wart. Among its related pathways are Immune System and CLEC7A (Dectin-1) signaling. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC4C.

UniProtKB/Swiss-Prot for CLEC6A Gene

  • Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC6A Gene

Genomics for CLEC6A Gene

Regulatory Elements for CLEC6A Gene

Enhancers for CLEC6A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F008672 0.6 FANTOM5 14.6 +216.7 216683 0.3 ZNF146 CLEC6A CLEC4E M6PR ENSG00000249790 CLEC4D ENSG00000255829 LOC101060064
GH12F008492 1.4 FANTOM5 Ensembl ENCODE 14.3 +37.3 37275 1.6 PKNOX1 TBL1XR1 ASH2L CHD4 BMI1 RELA CBX5 POLR2A EED ETV6 CLEC4E CLEC4D CLEC6A CLEC4A LINC00937 NECAP1 KLRG1 C3AR1 M6PR FOXJ2
GH12F008904 1 FANTOM5 Ensembl 11.4 +449.0 448975 1.0 CLEC6A CLEC4E M6PR CLEC2B CLEC4D PHC1 A2ML1-AS1
GH12F008455 1 Ensembl ENCODE 11.2 +0.1 57 1.2 CTCF ZNF654 TRIM22 RAD21 CBX5 POLR2A IKZF1 EED ZNF143 SMC3 CLEC6A RNU6-275P CLEC4E RPL15P17
GH12F008451 1 Ensembl ENCODE 10.8 -2.4 -2426 3.4 CBX8 POLR2A NRF1 POU5F1 CLEC6A LINC00937 OR7E149P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CLEC6A on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC6A Gene

Chromosome:
12
Start:
8,455,926 bp from pter
End:
8,478,330 bp from pter
Size:
22,405 bases
Orientation:
Plus strand

Genomic View for CLEC6A Gene

Genes around CLEC6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC6A Gene

Proteins for CLEC6A Gene

  • Protein details for CLEC6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EIG7-CLC6A_HUMAN
    Recommended name:
    C-type lectin domain family 6 member A
    Protein Accession:
    Q6EIG7
    Secondary Accessions:
    • A2RUK3

    Protein attributes for CLEC6A Gene

    Size:
    209 amino acids
    Molecular mass:
    23998 Da
    Quaternary structure:
    • Associated with FCER1G.

    Alternative splice isoforms for CLEC6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC6A Gene

Post-translational modifications for CLEC6A Gene

  • Glycosylation at Asn 131 and Asn 170
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC6A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLEC6A Gene

Domains & Families for CLEC6A Gene

Gene Families for CLEC6A Gene

Suggested Antigen Peptide Sequences for CLEC6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6EIG7

UniProtKB/Swiss-Prot:

CLC6A_HUMAN :
  • A short stretch of the intracellular domain (AA 8-14) proximal to the transmembrane domain is required for association with Fc receptor gamma chain.
Domain:
  • A short stretch of the intracellular domain (AA 8-14) proximal to the transmembrane domain is required for association with Fc receptor gamma chain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC6A: view

Function for CLEC6A Gene

Molecular function for CLEC6A Gene

UniProtKB/Swiss-Prot Function:
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by granulocyte-macrophage colony-stimulating factor (GM-CSF), TGF-beta 1, TNF-alpha and down-regulated by IL-4, IL-10 or UVB in CD14+ monocytes.

Gene Ontology (GO) - Molecular Function for CLEC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding ISS --
genes like me logo Genes that share ontologies with CLEC6A: view
genes like me logo Genes that share phenotypes with CLEC6A: view

Animal Models for CLEC6A Gene

MGI Knock Outs for CLEC6A:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC6A Gene

Localization for CLEC6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC6A Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC6A Gene COMPARTMENTS Subcellular localization image for CLEC6A gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for CLEC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC6A: view

Pathways & Interactions for CLEC6A Gene

genes like me logo Genes that share pathways with CLEC6A: view

Pathways by source for CLEC6A Gene

Interacting Proteins for CLEC6A Gene

Selected Interacting proteins: Q6EIG7-CLC6A_HUMAN for CLEC6A Gene via IID

Gene Ontology (GO) - Biological Process for CLEC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA,ISS --
GO:0045087 innate immune response ISS --
genes like me logo Genes that share ontologies with CLEC6A: view

No data available for SIGNOR curated interactions for CLEC6A Gene

Transcripts for CLEC6A Gene

mRNA/cDNA for CLEC6A Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC6A Gene

C-type lectin domain family 6, member A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC6A Gene

No ASD Table

Relevant External Links for CLEC6A Gene

GeneLoc Exon Structure for
CLEC6A
ECgene alternative splicing isoforms for
CLEC6A

Expression for CLEC6A Gene

mRNA expression in normal human tissues for CLEC6A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC6A Gene

This gene is overexpressed in Whole Blood (x36.5).

Protein differential expression in normal tissues from HIPED for CLEC6A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC6A Gene



Protein tissue co-expression partners for CLEC6A Gene

NURSA nuclear receptor signaling pathways regulating expression of CLEC6A Gene:

CLEC6A

SOURCE GeneReport for Unigene cluster for CLEC6A Gene:

Hs.591147

mRNA Expression by UniProt/SwissProt for CLEC6A Gene:

Q6EIG7-CLC6A_HUMAN
Tissue specificity: Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.
genes like me logo Genes that share expression patterns with CLEC6A: view

Primer Products

Orthologs for CLEC6A Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLEC6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC6A 34 35
  • 99.2 (n)
cow
(Bos Taurus)
Mammalia CLEC6A 34 35
  • 81.89 (n)
mouse
(Mus musculus)
Mammalia Clec4n 34 16 35
  • 76.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 44 (a)
OneToMany
Species where no ortholog for CLEC6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC6A Gene

ENSEMBL:
Gene Tree for CLEC6A (if available)
TreeFam:
Gene Tree for CLEC6A (if available)

Paralogs for CLEC6A Gene

(9) SIMAP similar genes for CLEC6A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLEC6A: view

Variants for CLEC6A Gene

Sequence variations from dbSNP and Humsavar for CLEC6A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10734709 -- 8,455,237(+) TTCTC(C/T)CCTGA upstream-variant-2KB
rs10743393 -- 8,458,452(+) AAAAT(A/G)TTTCT intron-variant
rs10743394 -- 8,458,832(+) ATTTG(A/G)TTGTA intron-variant
rs10743396 -- 8,458,892(+) TCAGA(C/T)CCTGA intron-variant
rs10770722 -- 8,455,630(+) TTACT(A/T)CCTAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLEC6A Gene

Variant ID Type Subtype PubMed ID
dgv1362n100 CNV gain 25217958
esv1064509 CNV deletion 17803354
esv2178781 CNV deletion 18987734
esv2587098 CNV deletion 19546169
esv2745506 CNV deletion 23290073
esv2759877 CNV gain+loss 17122850
esv3548718 CNV deletion 23714750
esv3580594 CNV gain 25503493
esv6604 CNV loss 19470904
nsv1035270 CNV gain 25217958
nsv1051530 CNV gain 25217958
nsv1069360 CNV deletion 25765185
nsv1121483 CNV deletion 24896259
nsv1148265 CNV deletion 26484159
nsv428270 CNV gain 18775914
nsv518125 CNV loss 19592680
nsv518772 CNV gain 19592680
nsv557342 CNV loss 21841781
nsv952797 CNV duplication 24416366
nsv958635 CNV deletion 24416366
nsv973016 CNV duplication 23825009

Variation tolerance for CLEC6A Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC6A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC6A Gene

Disorders for CLEC6A Gene

MalaCards: The human disease database

(2) MalaCards diseases for CLEC6A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cryptococcosis
  • busse-buschke's disease
common wart
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CLEC6A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC6A
genes like me logo Genes that share disorders with CLEC6A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLEC6A Gene

Publications for CLEC6A Gene

  1. Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2. (PMID: 15810886) Gavino A.C. … Cruz P.D. Jr. (Exp. Dermatol. 2005) 3 4 22 64
  2. Molecular cloning of human dectin-2. (PMID: 15175046) Kanazawa N. … Miyachi Y. (J. Invest. Dermatol. 2004) 3 4 22 64
  3. Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. (PMID: 15368084) Flornes L.M. … Fossum S. (Immunogenetics 2004) 3 4 22 64
  4. The Dectin-2 family of C-type lectins in immunity and homeostasis. (PMID: 19665392) Graham L.M. … Brown G.D. (Cytokine 2009) 3 22 64
  5. Signaling and immune regulatory role of the dendritic cell immunoreceptor (DCIR) family lectins: DCIR, DCAR, dectin-2 and BDCA-2. (PMID: 15481152) Kanazawa N. … Miyachi Y. (Immunobiology 2004) 3 22 64

Products for CLEC6A Gene

Sources for CLEC6A Gene

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