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Aliases for CLEC6A Gene

Aliases for CLEC6A Gene

  • C-Type Lectin Domain Family 6, Member A 2 3
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 10 2 3
  • Dendritic Cell-Associated C-Type Lectin 2 3 4
  • C-Type Lectin Superfamily Member 10 3 4
  • DC-Associated C-Type Lectin 2 3 4
  • Dectin-2 3 4
  • CLECSF10 3 4
  • CLEC4N 3 6
  • C-Type Lectin Domain Family 6 Member A 3
  • Dectin 2 3
  • DECTIN2 4

External Ids for CLEC6A Gene

Previous HGNC Symbols for CLEC6A Gene

  • CLECSF10

Previous GeneCards Identifiers for CLEC6A Gene

  • GC12U900496
  • GC12P008499
  • GC12P008608
  • GC12P008391

Summaries for CLEC6A Gene

Entrez Gene Summary for CLEC6A Gene

  • Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2, is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain (Kanazawa et al., 2004 [PubMed 15175046]).[supplied by OMIM, Nov 2010]

GeneCards Summary for CLEC6A Gene

CLEC6A (C-Type Lectin Domain Family 6, Member A) is a Protein Coding gene. Among its related pathways are NOD-like Receptor Signaling Pathways. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC4D.

UniProtKB/Swiss-Prot for CLEC6A Gene

  • Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC6A Gene

Genomics for CLEC6A Gene

Regulatory Elements for CLEC6A Gene

Genomic Location for CLEC6A Gene

Start:
8,455,926 bp from pter
End:
8,478,330 bp from pter
Size:
22,405 bases
Orientation:
Plus strand

Genomic View for CLEC6A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC6A Gene

Proteins for CLEC6A Gene

  • Protein details for CLEC6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EIG7-CLC6A_HUMAN
    Recommended name:
    C-type lectin domain family 6 member A
    Protein Accession:
    Q6EIG7
    Secondary Accessions:
    • A2RUK3

    Protein attributes for CLEC6A Gene

    Size:
    209 amino acids
    Molecular mass:
    23998 Da
    Quaternary structure:
    • Associated with FCER1G.

    Alternative splice isoforms for CLEC6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC6A Gene

Proteomics data for CLEC6A Gene at MOPED

Post-translational modifications for CLEC6A Gene

  • Glycosylation at Asn131 and Asn170

Other Protein References for CLEC6A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CLEC6A (Dectin-2/CLEC6A)

Protein Products

  • Enzo Life Sciences proteins for CLEC6A
  • Novus Biologicals lysates for CLEC6A

No data available for DME Specific Peptides for CLEC6A Gene

Domains for CLEC6A Gene

Gene Families for CLEC6A Gene

HGNC:
  • CLEC :C-type lectin domain containing

Protein Domains for CLEC6A Gene

Suggested Antigen Peptide Sequences for CLEC6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6EIG7

UniProtKB/Swiss-Prot:

CLC6A_HUMAN :
  • Q6EIG7
Domain:
  • A short stretch of the intracellular domain (AA 8-14) proximal to the transmembrane domain is required for association with Fc receptor gamma chain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC6A: view

Function for CLEC6A Gene

Molecular function for CLEC6A Gene

UniProtKB/Swiss-Prot Function: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated by granulocyte-macrophage colony-stimulating factor (GM-CSF), TGF-beta 1, TNF-alpha and down-regulated by IL-4, IL-10 or UVB in CD14+ monocytes.

Gene Ontology (GO) - Molecular Function for CLEC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030246 carbohydrate binding ISS --
genes like me logo Genes that share ontologies with CLEC6A: view
genes like me logo Genes that share phenotypes with CLEC6A: view

Animal Models for CLEC6A Gene

MGI Knock Outs for CLEC6A:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC6A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CLEC6A Gene

Localization for CLEC6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC6A Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC6A Gene COMPARTMENTS Subcellular localization image for CLEC6A gene
Compartment Confidence
plasma membrane 3
extracellular 2

Gene Ontology (GO) - Cellular Components for CLEC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC6A: view

Pathways for CLEC6A Gene

genes like me logo Genes that share pathways with CLEC6A: view

Pathways by source for CLEC6A Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CLEC6A Gene

Gene Ontology (GO) - Biological Process for CLEC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS --
GO:0045087 innate immune response TAS --
GO:0050715 positive regulation of cytokine secretion ISS --
GO:0050832 defense response to fungus ISS --
genes like me logo Genes that share ontologies with CLEC6A: view

Transcripts for CLEC6A Gene

mRNA/cDNA for CLEC6A Gene

(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC6A Gene

C-type lectin domain family 6, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC6A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CLEC6A
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC6A Gene

No ASD Table

Relevant External Links for CLEC6A Gene

GeneLoc Exon Structure for
CLEC6A
ECgene alternative splicing isoforms for
CLEC6A

Expression for CLEC6A Gene

mRNA expression in normal human tissues for CLEC6A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC6A Gene

This gene is overexpressed in Whole Blood (36.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CLEC6A Gene

SOURCE GeneReport for Unigene cluster for CLEC6A Gene Hs.591147

mRNA Expression by UniProt/SwissProt for CLEC6A Gene

Q6EIG7-CLC6A_HUMAN
Tissue specificity: Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.
genes like me logo Genes that share expressions with CLEC6A: view

In Situ Assay Products

Orthologs for CLEC6A Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLEC6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC6A 35
  • 99.2 (n)
  • 98.09 (a)
CLEC6A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLEC6A 35
  • 81.89 (n)
  • 72.84 (a)
CLEC6A 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec4n 35
  • 76.81 (n)
  • 69.57 (a)
Clec4n 16
Clec4n 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
OneToMany
Species with no ortholog for CLEC6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC6A Gene

ENSEMBL:
Gene Tree for CLEC6A (if available)
TreeFam:
Gene Tree for CLEC6A (if available)

Paralogs for CLEC6A Gene

Selected SIMAP similar genes for CLEC6A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLEC6A: view

Variants for CLEC6A Gene

Sequence variations from dbSNP and Humsavar for CLEC6A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4242888 -- 8,457,249(+) cctct(A/G)gtaac intron-variant
rs4242889 -- 8,463,213(+) GGCTT(C/T)GAGTG intron-variant
rs4242890 -- 8,463,796(+) GTAAC(G/T)TGATC intron-variant
rs4242891 -- 8,463,806(+) CAGCT(C/T)ATTAT intron-variant
rs4242892 -- 8,463,840(+) AAATA(C/T)TATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC6A Gene

Variant ID Type Subtype PubMed ID
dgv455e1 CNV Complex 17122850
nsv428270 CNV Gain 18775914
dgv461e1 CNV Complex 17122850
nsv518772 CNV Gain 19592680
nsv518125 CNV Loss 19592680
esv2587098 CNV Deletion 19546169
esv2178781 CNV Deletion 18987734
esv2745506 CNV Deletion 23290073
esv1064509 CNV Deletion 17803354
esv6604 CNV Loss 19470904

Relevant External Links for CLEC6A Gene

HapMap Linkage Disequilibrium report
CLEC6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC6A Gene

Disorders for CLEC6A Gene

(1) University of Copenhagen DISEASES for CLEC6A Gene

genes like me logo Genes that share disorders with CLEC6A: view

No data available for UniProtKB/Swiss-Prot for CLEC6A Gene

Publications for CLEC6A Gene

  1. Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2. (PMID: 15810886) Gavino A.C. … Cruz P.D. Jr. (Exp. Dermatol. 2005) 3 4 23
  2. Molecular cloning of human dectin-2. (PMID: 15175046) Kanazawa N. … Miyachi Y. (J. Invest. Dermatol. 2004) 3 4 23
  3. Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. (PMID: 15368084) Flornes L.M. … Fossum S. (Immunogenetics 2004) 3 4 23
  4. Signaling and immune regulatory role of the dendritic cell immunoreceptor (DCIR) family lectins: DCIR, DCAR, dectin-2 and BDCA-2. (PMID: 15481152) Kanazawa N. … Miyachi Y. (Immunobiology 2004) 23
  5. Organization of the mouse macrophage C-type lectin (Mcl) gene and identification of a subgroup of related lectin molecules. (PMID: 11841491) Balch S.G. … McKnight A.J. (Eur. J. Immunogenet. 2002) 23

Products for CLEC6A Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CLEC6A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC6A
    • Block miRNA regulation of CLEC6A using miScript Target Protectors

    Sources for CLEC6A Gene

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