Aliases for CLEC6A Gene
External Ids for CLEC6A Gene
Previous HGNC Symbols for CLEC6A Gene
Previous GeneCards Identifiers for CLEC6A Gene
Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2, is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain (Kanazawa et al., 2004 [PubMed 15175046]).[supplied by OMIM, Nov 2010]
GeneCards Summary for CLEC6A Gene
CLEC6A (C-Type Lectin Domain Family 6, Member A) is a Protein Coding gene. Diseases associated with CLEC6A include common wart. Among its related pathways are Immune System and CLEC7A (Dectin-1) signaling. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC4D.
UniProtKB/Swiss-Prot for CLEC6A Gene
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity).