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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC6A Gene

protein-coding   GIFtS: 46
GCID: GC12P008608

C-Type Lectin Domain Family 6, Member A

(Previous names: C-type (calcium dependent, carbohydrate-recognition domain)...)
(Previous symbol: CLECSF10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 6, Member A1 2     CLEC4N2 5
CLECSF101 2 3     C-Type Lectin Domain Family 6 Member A2
C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin,
Superfamily Member 101 2
     Dectin 22
Dendritic Cell-Associated C-Type Lectin 22 3     dectin-22
C-Type Lectin Superfamily Member 102 3     DECTIN23
DC-Associated C-Type Lectin 22 3     Dectin-23

External Ids:    HGNC: 145561   Entrez Gene: 939782   Ensembl: ENSG000002058467   OMIM: 6135795   UniProtKB: Q6EIG73   

Export aliases for CLEC6A gene to outside databases

Previous GC identifers: GC12U900496 GC12P008499 GC12P008391


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLEC6A Gene:
Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2, is a type II membrane receptor with an extracellular
C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based
activation motif (ITAM) in its cytoplasmic domain (Kanazawa et al., 2004 (PubMed 15175046)).(supplied by OMIM,
Nov 2010)

GeneCards Summary for CLEC6A Gene: 
CLEC6A (C-type lectin domain family 6, member A) is a protein-coding gene. Diseases associated with CLEC6A include superficial mycosis, and job's syndrome, and among its related super-pathways are Inflammasome Activation Pathways. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD207.

UniProtKB/Swiss-Prot: CLC6A_HUMAN, Q6EIG7
Function: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on
C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17
cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi,
by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni
altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and
Syk-CARD9-NF-kappa-B-dependent pathway (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC6A gene promoter:
         Nkx3-1 v4   Tal-1   AML1a   NRSF form 1   RREB-1   NRSF form 2   E47   MZF-1   c-Myb   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC6A promoter sequence
   Search SABiosciences Chromatin IP Primers for CLEC6A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC6A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

CLEC6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC6A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P008608:  view genomic region     (about GC identifiers)

Start:
8,608,522 bp from pter      End:
8,630,926 bp from pter
Size:
22,405 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLC6A_HUMAN, Q6EIG7 (See protein sequence)
Recommended Name: C-type lectin domain family 6 member A  
Size: 209 amino acids; 23998 Da
Subunit: Associated with FCER1G (By similarity)
Subcellular location: Membrane; Single-pass type II membrane protein (Probable)
Secondary accessions: A2RUK3
Alternative splicing: 2 isoforms:  Q6EIG7-1   Q6EIG7-2   

Explore the universe of human proteins at neXtProt for CLEC6A: NX_Q6EIG7

CLEC6A Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001007034.1  
ENSEMBL proteins: 
 ENSP00000371505  

Human Recombinant Protein Products for CLEC6A: 
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Enzo Life Sciences proteins for CLEC6A
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OriGene Protein Over-expression Lysate for CLEC6A
OriGene Custom MassSpec 
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Novus Biologicals CLEC6A Lysate
Sino Biological Recombinant Protein for CLEC6A
Sino Biological Cell Lysate for CLEC6A 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for CLEC6A 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

CLEC6A for ontologies           About GeneDecksing



CLEC6A Antibody Products: 
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Abcam antibodies for CLEC6A
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ThermoFisher Antibody for CLEC6A
LSBio Antibodies in human, mouse, rat for CLEC6A 

Assay Products for CLEC6A: 
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Cloud-Clone Corp. ELISAs for CLEC6A 
Cloud-Clone Corp. CLIAs for CLEC6A


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CLEC: C-type lectin domain containing

3 InterPro protein domains:
 IPR016187 C-type_lectin_fold
 IPR016186 C-type_lectin-like
 IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry Q6EIG7

ProtoNet protein and cluster: Q6EIG7

1 Blocks protein domain: IPB002353 Type II antifreeze protein signature

UniProtKB/Swiss-Prot: CLC6A_HUMAN, Q6EIG7
Domain: A short stretch of the intracellular domain (AA 8-14) proximal to the transmembrane domain is required for
association with Fc receptor gamma chain (By similarity)
Similarity: Contains 1 C-type lectin domain


CLEC6A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CLC6A_HUMAN, Q6EIG7
Function: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on
C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17
cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi,
by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni
altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and
Syk-CARD9-NF-kappa-B-dependent pathway (By similarity)
Induction: Up-regulated by granulocyte-macrophage colony-stimulating factor (GM-CSF), TGF-beta 1, TNF-alpha and
down-regulated by IL-4, IL-10 or UVB in CD14+ monocytes

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0030246carbohydrate binding ISS--
     
CLEC6A for ontologies           About GeneDecksing


Phenotypes:
     5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Clec4n):
 cellular  hematopoietic system  immune system  mortality/aging  renal/urinary system 

CLEC6A for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Clec4ntm1Yiw for CLEC6A

   inGenious Targeting Laboratory - Custom generated mouse model solutions for CLEC6A 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLEC6A

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC6A 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLEC6A 

miRNA
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLEC6A
SwitchGear 3'UTR luciferase reporter plasmidCLEC6A 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CLEC6A
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC6A

Gene Editing
Products:
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Sirion Biotech Customized adenovirus for overexpression of CLEC6A

Clone
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OriGene ORF clones in mouse, rat for CLEC6A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CLEC6A (NM_001007033)
Sino Biological Human cDNA Clone for CLEC6A
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC6A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC6A
Sirion Biotech Customized lentivirus for stable overexpression of CLEC6A 
                     Customized lentivirus expression plasmids for stable overexpression of CLEC6A 

Cell Line
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GenScript Custom overexpressing Cell Line Services for CLEC6A
Search LifeMap BioReagents cell lines for CLEC6A
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC6A


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CLEC6A About                                                                                                See pathways by source

SuperPathContained pathways About
1Toll-Like receptor Signaling Pathways
Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for CLEC6A
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC6A

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade ISS--
GO:0045087innate immune response ISS--
GO:0050715positive regulation of cytokine secretion ISS--
GO:0050832defense response to fungus ISS--

CLEC6A for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLEC6A (CLC6A)

Search CenterWatch for drugs/clinical trials and news about CLEC6A / CLC6A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLEC6A gene: 
NM_001007033.1  

Unigene Cluster for CLEC6A:

C-type lectin domain family 6, member A
Hs.591147  [show with all ESTs]
Unigene Representative Sequence: AY321309
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000382073(uc001qum.1)
miRNA
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLEC6A
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Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC6A
Clone
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OriGene clones in human, mouse for CLEC6A (see all 6)
OriGene ORF clones in mouse, rat for CLEC6A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CLEC6A (NM_001007033)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC6A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC6A
Sirion Biotech Customized lentivirus for stable overexpression of CLEC6A 
                     Customized lentivirus expression plasmids for stable overexpression of CLEC6A 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for CLEC6A
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC6A
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC6A
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC6A

Additional mRNA sequence: 

AK308011.1 AY321309.1 AY365135.1 BC132933.1 BC132935.1 

1 DOTS entry:

DT.121175086 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLEC6A expression in normal human tissues (normalized intensities)      CLEC6A embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCTGGCAACT
CLEC6A Expression
About this image


CLEC6A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         Monocytes Peripheral Blood
 
 Bone (Muscoskeletal System)
         Zeugopod Periosteum
 
 Lateral Plate Mesoderm (Gastrulation Derivatives)
         Hematopoietic Stem Cells Aorta-Gonad-Mesonephros

SOURCE GeneReport for Unigene cluster: Hs.591147

UniProtKB/Swiss-Prot: CLC6A_HUMAN, Q6EIG7
Tissue specificity: Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells.
Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially
expressed in plasmacytoids rather than myeloids

    SABiosciences Expression via Pathway-Focused PCR Array including CLEC6A: 
          Antifungal Response in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for CLEC6A
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC6A
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC6A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC6A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for CLEC6A gene from 1/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Clec4n1 , 5 C-type lectin domain family 4, member n1, 5 77.13(n)1
69.57(a)1
  6 (58.30 cM)5
566201  NM_020001.21  NP_064385.11 
 1232298435 


ENSEMBL Gene Tree for CLEC6A (if available)
TreeFam Gene Tree for CLEC6A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CLEC6A gene
CD2072  CLEC17A2  CLEC4E2  ASGR22  CLEC4M2  CLEC4F2  CD2092  CLEC4A2  
FCER22  CLEC10A2  ASGR12  CLEC4C2  CLEC4D2  CLEC4G2  
9 SIMAP similar genes for CLEC6A using alignment to 1 protein entry:     CLC6A_HUMAN:
CLEC4C    CLEC4D    CLEC4A    CLEC4M    COLEC12    ASGR2
CD209    CLEC10A    CLEC4E

CLEC6A for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/615 SNPs in CLEC6A are shown (see all 615)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs46161191,2
C,F,A--8486349(+) ttcttT/Cttgcc 1 -- us2k1 trp312Minor allele frequency- C:0.23NA WA CSA EA 376
rs1472023121,2
--8486375(+) AATTTA/GCAAAG 1 -- us2k10--------
rs42961041,2
C,F,A,H--8486380(+) ACAAAA/GACAAA 1 -- us2k1 tfbs313Minor allele frequency- G:0.17NS EA NA WA 636
rs43874291,2
C,F,A--8486396(+) TCCTGC/TCTTCC 1 -- us2k1 trp311Minor allele frequency- T:0.22NA WA CSA EA 373
rs1404872031,2
--8486518(+) GAATCA/GTGAAG 1 -- us2k10--------
rs44203481,2
C,F,A,H--8486636(+) CACTTC/GTAGGT 1 -- us2k112Minor allele frequency- G:0.33NA WA CSA 257
rs44203491,2
C,F,A,H--8486639(+) TTGTAT/GGTTGC 1 -- us2k111Minor allele frequency- G:0.33NA WA CSA 255
rs1842639161,2
--8486660(+) GGTCTA/GGAGAG 1 -- us2k10--------
rs44203501,2
C,F,A,H--8486665(+) AGAGAA/GCAAAG 1 -- us2k114Minor allele frequency- G:0.24NA WA CSA EA 493
rs1164813381,2
F--8486727(+) CCATCC/ACAAAT 1 -- us2k11Minor allele frequency- A:0.04WA 118

HapMap Linkage Disequilibrium report for CLEC6A (8608522 - 8630926 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for CLEC6A:    About this table     
Variant IDTypeSubtypePubMed ID
esv2178781CNV Deletion18987734
esv2587098CNV Deletion19546169
esv2745506CNV Deletion23290073
esv1064509CNV Deletion17803354
nsv518125CNV Loss19592680
esv6604CNV Loss19470904
nsv518772CNV Gain19592680
nsv428270CNV Gain18775914
dgv461e1CNV Complex17122850
dgv455e1CNV Complex17122850

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CLEC6A
DNA2.0 Custom Variant and Variant Library Synthesis for CLEC6A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 613579    OMIM disorders: --

5 diseases for CLEC6A:    About MalaCards
superficial mycosis    job's syndrome    chronic mucocutaneous candidiasis    tonsillitis
candidiasis

1 disease from the University of Copenhagen DISEASES database for CLEC6A:
Job's syndrome

CLEC6A for disorders           About GeneDecksing


Export disorders for CLEC6A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CLEC6A gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with CLEC6A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2. (PubMed id 15810886)1, 2, 9 Gavino A.C....Cruz P.D. (2005)
  2. Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. (PubMed id 15368084)1, 2, 9 Flornes L.M....Fossum S. (2004)
  3. Molecular cloning of human dectin-2. (PubMed id 15175046)1, 2, 9 Kanazawa N....Miyachi Y. (2004)
  4. Selective C-Rel activation via Malt1 controls anti-fu ngal T(H)-17 immunity by dectin-1 and dectin-2. (PubMed id 21283787)1 Gringhuis S.I....Geijtenbeek T.B. (2011)
  5. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. Identification and gene expression of bovine C-type lectin dectin-2. (PubMed id 16213030)9 Bonkobara M....Ariizumi K. (2006)
  9. The Dectin-2 family of C-type lectins in immunity and homeostasis. (PubMed id 19665392)9 Graham L.M. and Brown G.D. (2009)
  10. Induction of CD8+ T cell responses through targeting of antigen to Dectin-2. (PubMed id 16781694)9 Carter R.W....Tough D.F. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 93978 HGNC: 14556 Ensembl:ENSG00000205846 euGenes: HUgn93978 ECgene: CLEC6A
H-InvDB: CLEC6A

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CLEC6A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CLEC6A gene:
Search GeneIP for patents involving CLEC6A

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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