Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CLEC5A Gene

protein-coding   GIFtS: 53
GCID: GC07M141627

C-Type Lectin Domain Family 5, Member A

(Previous names: C-type (calcium dependent, carbohydrate-recognition domain)...)
(Previous symbol: CLECSF5)
  See CLEC5A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
C-Type Lectin Domain Family 5, Member A1 2     MDL-12 3
CLECSF51 2 3 5     C-Type Lectin Superfamily Member 52 3
MDL12 3 5     C-Type Lectin Domain Family 5 Member A2
C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin,
Superfamily Member 51 2
     Myeloid DAP12-Associating Lectin-12
Myeloid DAP12-Associating Lectin 12 3     

External Ids:    HGNC: 20541   Entrez Gene: 236012   Ensembl: ENSG000002582277   OMIM: 6049875   UniProtKB: Q9NY253   

Export aliases for CLEC5A gene to outside databases

Previous GC identifers: GC07M141081 GC07M141273 GC07M135923


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CLEC5A Gene:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this
family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling,
glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein
interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants
have been described but their full-length sequence has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLEC5A Gene:
CLEC5A (C-type lectin domain family 5, member A) is a protein-coding gene. Diseases associated with CLEC5A include dengue disease. GO annotations related to this gene include carbohydrate binding and virus receptor activity.

UniProtKB/Swiss-Prot: CLC5A_HUMAN, Q9NY25
Function: Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP.
Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune
joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of
dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result
in viral entry, but stimulates proinflammatory cytokine release

Gene Wiki entry for CLEC5A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLEC5A gene promoter:
         Nkx3-1   Nkx3-1 v4   HOXA3   MEF-2   Nkx3-1 v1   Nkx3-1 v2   PPAR-gamma1   Nkx3-1 v3   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC5A promoter sequence
   Search Chromatin IP Primers for CLEC5A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

CLEC5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC5A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M141627:  view genomic region     (about GC identifiers)

Start:
141,627,157 bp from pter      End:
141,646,807 bp from pter
Size:
19,651 bases      Orientation:
minus strand

2 alternative locations:
Chr7-,CRA_TCAG 140,965,368-140,984,972      Chr7-,NW_003571040 69,308-88,934     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CLC5A_HUMAN, Q9NY25 (See protein sequence)
Recommended Name: C-type lectin domain family 5 member A  
Size: 188 amino acids; 21521 Da
Subunit: Monomer. Homodimer. The majority of CLEC5A is expressed as a monomeric form on macrophages. Interacts
with TYROBP/DAP12. The interaction with TYROBP is required for CLEC5 cell surface expression. Interacts with
HCST/DAP10. Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP
1 PDB 3D structure from and Proteopedia for CLEC5A:
2YHF (3D)    
Secondary accessions: Q52M11 Q9UKQ0
Alternative splicing: 2 isoforms:  Q9NY25-1   Q9NY25-2   

Explore the universe of human proteins at neXtProt for CLEC5A: NX_Q9NY25

Explore proteomics data for CLEC5A at MOPED

Post-translational modifications: 

  • N-glycosylated. Contains sialic acid residues (By similarity)1
  • Glycosylation2 at Asn32, Asn93, Asn144, Asn151

  • See CLEC5A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037384.1  
    ENSEMBL proteins: 
     ENSP00000449999   ENSP00000392561   ENSP00000446890   ENSP00000395258   ENSP00000414897  
    Reactome Protein details: Q9NY25

    CLEC5A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CLEC5A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CLEC5A
    GenScript Custom Purified and Recombinant Proteins Services for CLEC5A
    Novus Biologicals CLEC5A Protein
    Novus Biologicals CLEC5A Lysates
    Sino Biological Recombinant Protein for CLEC5A
    Sino Biological Cell Lysate for CLEC5A
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLEC5A

     
    Search eBioscience for Proteins for CLEC5A 

    CLEC5A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CLEC5A (MDL-1/CLEC5A)
    OriGene Antibodies for CLEC5A
    OriGene Custom Antibody Services for CLEC5A
    Novus Biologicals CLEC5A Antibody
    Abcam antibodies for CLEC5A
    Cloud-Clone Corp. Antibodies for CLEC5A
    Search ThermoFisher Antibodies for CLEC5A
    LSBio Antibodies in human, mouse, rat for CLEC5A

    CLEC5A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CLEC5A
    R&D Systems Proteome Profiler Antibody Arrays for CLEC5A (MDL-1/CLEC5A)
    GenScript Custom Assay Services for CLEC5A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLEC5A
    Cloud-Clone Corp. CLIAs for CLEC5A
    Search eBioscience for ELISAs for CLEC5A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q9NY25

    ProtoNet protein and cluster: Q9NY25

    UniProtKB/Swiss-Prot: CLC5A_HUMAN, Q9NY25
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with CLEC5A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLC5A_HUMAN, Q9NY25
    Function: Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP.
    Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune
    joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of
    dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result
    in viral entry, but stimulates proinflammatory cytokine release

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IDA18496526
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with CLEC5A           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CLEC5A:
     Increased S DNA content  Increased number of mitotic ce  Large nuclei 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Clec5a):
     immune system  skeleton 

    Find genes that share phenotypes with CLEC5A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Clec5atm1Cua for CLEC5A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLEC5A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLEC5A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC5A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLEC5A

    miRNA
    Products:
        
    miRTarBase miRNAs that target CLEC5A:
    hsa-mir-877-3p (MIRT036848)

    Block miRNA regulation of human, mouse, rat CLEC5A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLEC5A (see all 15):
    hsa-miR-3618 hsa-miR-136 hsa-miR-4254 hsa-miR-934 hsa-miR-548e hsa-miR-578 hsa-miR-373* hsa-miR-1270
    SwitchGear 3'UTR luciferase reporter plasmidCLEC5A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLEC5A
    Predesigned siRNA for gene silencing in human, mouse, rat CLEC5A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLEC5A

    Clone
    Products:
         
    OriGene clones in human, mouse for CLEC5A (see all 7)
    OriGene ORF clones in mouse, rat for CLEC5A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLEC5A (NM_013252)
    Sino Biological Human cDNA Clone for CLEC5A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC5A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CLEC5A
    Browse ESI BIO Cell Lines and PureStem Progenitors for CLEC5A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC5A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CLC5A_HUMAN, Q9NY25: Cell membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10449773
    GO:0009986cell surface ISS--

    Find genes that share ontologies with CLEC5A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CLEC5A About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    DAP12 interactions0.89


    Find genes that share SuperPaths with CLEC5A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CLEC5A
        DAP12 interactions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLEC5A
    Interactions:

        GeneGlobe Interaction Network for CLEC5A

    1 Interacting protein for CLEC5A (Q9NY253) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TYROBPO439143I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002076osteoblast development ISS--
    GO:0006968cellular defense response TAS10449773
    GO:0007165signal transduction TAS10449773
    GO:0009615response to virus IDA18496526
    GO:0016032viral process IEA--

    Find genes that share ontologies with CLEC5A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLEC5A (CLC5A)

    1 HMDB Compound for CLEC5A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CLEC5A gene: 
    NM_013252.2  

    Unigene Cluster for CLEC5A:

    C-type lectin domain family 5, member A
    Hs.446235  [show with all ESTs]
    Unigene Representative Sequence: NM_013252
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546910(uc011krm.1 uc003vwv.1 uc003vww.1 uc010lnq.1 uc010lnr.1)
    ENST00000418498 ENST00000551012 ENST00000439991 ENST00000438351 ENST00000470595
    ENST00000481301
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLEC5A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLEC5A (see all 15):
    hsa-miR-3618 hsa-miR-136 hsa-miR-4254 hsa-miR-934 hsa-miR-548e hsa-miR-578 hsa-miR-373* hsa-miR-1270
    SwitchGear 3'UTR luciferase reporter plasmidCLEC5A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CLEC5A
    Predesigned siRNA for gene silencing in human, mouse, rat CLEC5A
    Clone
    Products:
         
    OriGene clones in human, mouse for CLEC5A (see all 7)
    OriGene ORF clones in mouse, rat for CLEC5A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLEC5A (NM_013252)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC5A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CLEC5A
    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC5A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC5A
      QuantiTect SYBR Green Assays in human, mouse, rat CLEC5A
      QuantiFast Probe-based Assays in human, mouse, rat CLEC5A

    Additional mRNA sequence: 

    AF139768.1 AJ271684.1 AK292766.1 AK295200.1 AK307095.1 AK313703.1 BC093714.1 BC112099.1 
    BC113098.1 BC113099.1 BC143392.1 

    2 DOTS entries:

    DT.40126468  DT.95110725 

    Selected AceView cDNA sequences (see all 33):

    CD678553 AL601652 NM_013252 BQ446122 AI418484 AI653660 AI932965 AI635614 
    AI732898 AA722475 AW292460 AI394308 AW076117 CD641133 BX282186 AJ271684 
    BU198156 CD364647 BQ005467 AI393074 BF905853 BE466448 AV715134 AF139768 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CLEC5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLEC5A Expression
    About this image

    CLEC5A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLEC5A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446235

    UniProtKB/Swiss-Prot: CLC5A_HUMAN, Q9NY25
    Tissue specificity: Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and
    Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate
    into dendritic cells

        Custom PCR Arrays for CLEC5A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CLEC5A
    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC5A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC5A
    QuantiTect SYBR Green Assays in human, mouse, rat CLEC5A
    QuantiFast Probe-based Assays in human, mouse, rat CLEC5A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC5A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC5A gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec5a1 , 5 C-type lectin domain family 5, member a1, 5 82.34(n)1
    73.51(a)1
      6 (18.82 cM)5
    238451  NM_001038604.11  NP_001033693.11 
     405748945 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    32(a)
    17(a)
    1 ↔ many
    1 ↔ many
    GL343257.1(1953142-1980877)
    GL343585.1(305358-336045)


    ENSEMBL Gene Tree for CLEC5A (if available)
    TreeFam Gene Tree for CLEC5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CLEC5A gene
    4 SIMAP similar genes for CLEC5A using alignment to 5 protein entries:     CLC5A_HUMAN (see all proteins):
    CLECSF5    CLEC4C    KLRC2    CLEC4M

    Find genes that share paralogs with CLEC5A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CLEC5A (see all 556)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906208561,2
    --141626673(+) ACACCA/CCACGA 1 -- ds50010--------
    rs1126710441,2
    C,F--141626690(+) CTGGTG/ATGTGA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs12859321,2
    C,F,A--141626754(+) gagaaC/Tatgtg 1 -- ds50014Minor allele frequency- T:0.38NA 8
    rs1809740581,2
    --141626759(+) TATGTG/TGTGTT 1 -- ds50010--------
    rs1835714321,2
    --141626965(+) TGCCAA/CAATAA 1 -- ds50010--------
    rs1491336301,2
    C--141626984(+) GTGCAA/TGTGTC 1 -- ds50010--------
    rs1114164241,2
    C,F--141627053(+) TCAAAC/TGGTAT 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1160327211,2
    C,F--141627085(+) GAATCG/ACCACA 1 -- ds50013Minor allele frequency- A:0.03WA NA EA 358
    rs12859331,2
    C,F,A,H--141627149(+) cagggG/Agctga 1 -- ds500127Minor allele frequency- A:0.45NS EA NA WA CSA 2772
    rs77800671,2
    C,F,H--141627150(+) aggggG/Tctgaa 1 -- ds50014Minor allele frequency- T:0.01NS NA 506

    HapMap Linkage Disequilibrium report for CLEC5A (141627157 - 141646807 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CLEC5A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5974CNV Loss18451855
    nsv831161CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CLEC5A
    DNA2.0 Custom Variant and Variant Library Synthesis for CLEC5A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604987    OMIM disorders: --

    1 disease for CLEC5A:    
    About MalaCards
    dengue disease

    1 disease from the University of Copenhagen DISEASES database for CLEC5A:
    Dengue disease

    Find genes that share disorders with CLEC5A           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: CLEC5A (1 document)

    Export disorders for CLEC5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CLEC5A gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with CLEC5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. (PubMed id 10449773)1, 2, 3 Bakker A.B.H.... Lanier L.L. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    2. CLEC5A is critical for dengue-virus-induced lethal disease. (PubMed id 18496526)1, 2, 9 Chen S.T.... Hsieh S.L. (Nature 2008)
    3. Structural flexibility of the macrophage dengue virus receptor CLEC5A: Implications for ligand binding and signaling. (PubMed id 21566123)1, 2 Watson A.A.... O'Callaghan C.A. (J. Biol. Chem. 2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    6. Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor. (PubMed id 20057064)1, 9 Watson A.A. and O'Callaghan C.A. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010)
    7. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (Int J Eat Disord 2013)
    8. CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. (PubMed id 23152543)1 Wu M.F....Hsieh S.L. (Blood 2013)
    9. Lack of association between CLEC5A gene single-nucleotide polymorphisms and Kawasaki disease in Taiwanese children. (PubMed id 22536019)1 Yang Y.L....Chang W.C. (amp 2012)
    10. CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation. (PubMed id 21094529)1 Batliner J....Tschan M.P. (Mol. Immunol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23601 HGNC: 2054 AceView: CLECSF5 Ensembl:ENSG00000258227 euGenes: HUgn23601
    ECgene: CLEC5A H-InvDB: CLEC5A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CLEC5A Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_244

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CLEC5A gene:
    Search GeneIP for patents involving CLEC5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CLEC5A (MDL-1/CLEC5A)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for CLEC5A (MDL-1/CLEC5A)  
     OriGene Antibodies for CLEC5A   OriGene RNAi products in human, mouse, rat for CLEC5A  
     OriGene qPCR primer pairs and template standards for CLEC5A   OriGene Protein Over-expression Lysate for CLEC5A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CLEC5A  
     OriGene qSTAR qPCR primer pairs in human, mouse for CLEC5A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CLEC5A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLEC5A   OriGene Custom Protein Services for CLEC5A  

     
     
     Block miRNA regulation of human, mouse, rat CLEC5A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CLEC5A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC5A Predesigned siRNA for gene silencing in human, mouse, rat CLEC5A
     QuantiFast Probe-based Assays in human, mouse, rat CLEC5A QuantiTect SYBR Green Assays in human, mouse, rat CLEC5A
     Custom PCR Arrays for CLEC5A Search Chromatin IP Primers for CLEC5A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC5A  GeneGlobe Interaction Network for CLEC5A
     Regulatory tfbs in CLEC5A promoter
     GenScript Custom Purified and Recombinant Proteins Services for CLEC5A GenScript cDNA clones with any tag delivered in your preferred vector for CLEC5A
     GenScript Custom Assay Services for CLEC5A GenScript Custom overexpressing Cell Line Services for CLEC5A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CLEC5A (CLC5A)
     Proteins for CLEC5A
     Cell Lysates for CLEC5A
     cDNA Clones for CLEC5A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CLEC5A antibodies
     CLEC5A proteins
     CLEC5A lysates
     Antibodies for CLEC5A
     See all of Abcam's Antibodies, Kits and Proteins for CLEC5A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CLEC5A
     Antibodies for CLEC5A
     ELISAs for CLEC5A
     CLIAs for CLEC5A



     Browse ESI BIO Cell Lines and PureStem Progenitors for CLEC5A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC5A
     SwitchGear 3'UTR luciferase reporter plasmids for CLEC5A
     SwitchGear Promoter luciferase reporter plasmids for CLEC5A
     Search ThermoFisher Antibodies for CLEC5A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC5A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLEC5A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLEC5A
     LSBio Antibodies in human, mouse, rat for CLEC5A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CLEC5A
      Search eBioscience for proteins for CLEC5A
      Search eBioscience for elisas for CLEC5A
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CLEC5A gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4