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Aliases for CLEC5A Gene

Aliases for CLEC5A Gene

  • C-Type Lectin Domain Family 5 Member A 2 3 5
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 5 2 3
  • C-Type Lectin Domain Family 5, Member A 2 3
  • Myeloid DAP12-Associating Lectin 1 3 4
  • C-Type Lectin Superfamily Member 5 3 4
  • CLECSF5 3 4
  • MDL-1 3 4
  • MDL1 3 4
  • Myeloid DAP12-Associating Lectin-1 3

External Ids for CLEC5A Gene

Previous HGNC Symbols for CLEC5A Gene

  • CLECSF5

Previous GeneCards Identifiers for CLEC5A Gene

  • GC07M141081
  • GC07M141273
  • GC07M141627
  • GC07M135923

Summaries for CLEC5A Gene

Entrez Gene Summary for CLEC5A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLEC5A Gene

CLEC5A (C-Type Lectin Domain Family 5 Member A) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Immune System. GO annotations related to this gene include carbohydrate binding and virus receptor activity.

UniProtKB/Swiss-Prot for CLEC5A Gene

  • Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4.

  • (Microbial infection) May act as a receptor for dengue virus on macrophages. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

Gene Wiki entry for CLEC5A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC5A Gene

Genomics for CLEC5A Gene

Regulatory Elements for CLEC5A Gene

Enhancers for CLEC5A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLEC5A on UCSC Golden Path with GeneCards custom track

Promoters for CLEC5A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLEC5A on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC5A Gene

Chromosome:
7
Start:
141,927,357 bp from pter
End:
141,947,007 bp from pter
Size:
19,651 bases
Orientation:
Minus strand

Genomic View for CLEC5A Gene

Genes around CLEC5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC5A Gene

Proteins for CLEC5A Gene

  • Protein details for CLEC5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY25-CLC5A_HUMAN
    Recommended name:
    C-type lectin domain family 5 member A
    Protein Accession:
    Q9NY25
    Secondary Accessions:
    • Q52M11
    • Q9UKQ0

    Protein attributes for CLEC5A Gene

    Size:
    188 amino acids
    Molecular mass:
    21521 Da
    Quaternary structure:
    • Monomer. Homodimer. The majority of CLEC5A is expressed as a monomeric form on macrophages. Interacts with TYROBP/DAP12. The interaction with TYROBP is required for CLEC5 cell surface expression. Interacts with HCST/DAP10. Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP.
    • (Microbial infection) Interacts with dengue virus envelope protein E (PubMed:18496526, PubMed:21566123).

    Three dimensional structures from OCA and Proteopedia for CLEC5A Gene

    Alternative splice isoforms for CLEC5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC5A Gene

Proteomics data for CLEC5A Gene at MOPED

Post-translational modifications for CLEC5A Gene

  • N-glycosylated. Contains sialic acid residues (By similarity).
  • Glycosylation at Asn 32, Asn 93, Asn 144, and Asn 151

Other Protein References for CLEC5A Gene

Antibody Products

  • R&D Systems Antibodies for CLEC5A (MDL-1/CLEC5A)

No data available for DME Specific Peptides for CLEC5A Gene

Domains & Families for CLEC5A Gene

Gene Families for CLEC5A Gene

Protein Domains for CLEC5A Gene

Graphical View of Domain Structure for InterPro Entry

Q9NY25

UniProtKB/Swiss-Prot:

CLC5A_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC5A: view

Function for CLEC5A Gene

Molecular function for CLEC5A Gene

UniProtKB/Swiss-Prot Function:
Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4.
UniProtKB/Swiss-Prot Function:
(Microbial infection) May act as a receptor for dengue virus on macrophages. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

Gene Ontology (GO) - Molecular Function for CLEC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IDA 18496526
genes like me logo Genes that share ontologies with CLEC5A: view
genes like me logo Genes that share phenotypes with CLEC5A: view

Animal Models for CLEC5A Gene

MGI Knock Outs for CLEC5A:

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC5A

miRNA for CLEC5A Gene

miRTarBase miRNAs that target CLEC5A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLEC5A Gene

Localization for CLEC5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC5A Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC5A Gene COMPARTMENTS Subcellular localization image for CLEC5A gene
Compartment Confidence
plasma membrane 4
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CLEC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CLEC5A: view

Pathways & Interactions for CLEC5A Gene

genes like me logo Genes that share pathways with CLEC5A: view

Pathways by source for CLEC5A Gene

3 Reactome pathways for CLEC5A Gene

Interacting Proteins for CLEC5A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000449999%0d%0a9606.ENSP00000262629%0d%0a9606.ENSP00000246551%0d%0a
Selected Interacting proteins: Q9NY25-CLC5A_HUMAN ENSP00000449999 for CLEC5A Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CLEC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10449773
GO:0030099 myeloid cell differentiation IEA --
GO:0043066 negative regulation of apoptotic process IEA,ISS --
GO:0045087 innate immune response IEA,TAS --
genes like me logo Genes that share ontologies with CLEC5A: view

No data available for SIGNOR curated interactions for CLEC5A Gene

Drugs & Compounds for CLEC5A Gene

(1) Drugs for CLEC5A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CLEC5A: view

Transcripts for CLEC5A Gene

Unigene Clusters for CLEC5A Gene

C-type lectin domain family 5, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC5A Gene

No ASD Table

Relevant External Links for CLEC5A Gene

GeneLoc Exon Structure for
CLEC5A
ECgene alternative splicing isoforms for
CLEC5A

Expression for CLEC5A Gene

mRNA expression in normal human tissues for CLEC5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC5A Gene

This gene is overexpressed in Whole Blood (x18.0).

SOURCE GeneReport for Unigene cluster for CLEC5A Gene Hs.446235

mRNA Expression by UniProt/SwissProt for CLEC5A Gene

Q9NY25-CLC5A_HUMAN
Tissue specificity: Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells.
genes like me logo Genes that share expression patterns with CLEC5A: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CLEC5A Gene

Orthologs for CLEC5A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC5A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLEC5A 35
  • 82.16 (n)
  • 73.51 (a)
CLEC5A 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC5A 35
  • 80.07 (n)
  • 67.93 (a)
CLEC5A 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec5a 35
  • 82.34 (n)
  • 73.51 (a)
Clec5a 16
Clec5a 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLEC5A 35
  • 99.65 (n)
  • 99.47 (a)
CLEC5A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clec5a 35
  • 81.98 (n)
  • 73.51 (a)
oppossum
(Monodelphis domestica)
Mammalia CLEC5A 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
-- 36
  • 17 (a)
OneToMany
Species with no ortholog for CLEC5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC5A Gene

ENSEMBL:
Gene Tree for CLEC5A (if available)
TreeFam:
Gene Tree for CLEC5A (if available)

Paralogs for CLEC5A Gene

(4) SIMAP similar genes for CLEC5A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CLEC5A: view

No data available for Paralogs for CLEC5A Gene

Variants for CLEC5A Gene

Sequence variations from dbSNP and Humsavar for CLEC5A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_050110 -

Structural Variations from Database of Genomic Variants (DGV) for CLEC5A Gene

Variant ID Type Subtype PubMed ID
nsv831161 CNV Loss 17160897
nsv5974 CNV Loss 18451855

Variation tolerance for CLEC5A Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC5A Gene

HapMap Linkage Disequilibrium report
CLEC5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC5A Gene

Disorders for CLEC5A Gene

Relevant External Links for CLEC5A

Human Genome Epidemiology (HuGE) Navigator
CLEC5A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC5A

No disorders were found for CLEC5A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC5A Gene

Publications for CLEC5A Gene

  1. Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. (PMID: 10449773) Bakker A.B.H. … Lanier L.L. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 67
  2. Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor. (PMID: 20057064) Watson A.A. … O'Callaghan C.A. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010) 3 23
  3. CLEC5A is critical for dengue-virus-induced lethal disease. (PMID: 18496526) Chen S.T. … Hsieh S.L. (Nature 2008) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A potential role of myeloid DAP12-associating lectin (MDL)-1 in the regulation of inflammation in rheumatoid arthritis patients. (PMID: 24465901) Chen D.Y. … Hsieh S.L. (PLoS ONE 2014) 3

Products for CLEC5A Gene

Sources for CLEC5A Gene

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