Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CLEC4M Gene

protein-coding   GIFtS: 60
GCID: GC19P007828

C-Type Lectin Domain Family 4, Member M

(Previous name: CD299 antigen)
(Previous symbols: CD209L, CD299)
  See CLEC4M-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
C-Type Lectin Domain Family 4, Member M1 2     CD209 Antigen-Like Protein 12 3
CD209L1 2 3 5     DC-SIGN-Related Protein2 3
CD2991 2 3     DCSIGNR2 5
CD299 Antigen1 2 3     LSIGN2 5
Dendritic Cell-Specific ICAM-3-Grabbing Non-Integrin 22 3     HP103472
Liver/Lymph Node-Specific ICAM-3-Grabbing Non-Integrin2 3     C-Type Lectin Domain Family 4 Member M2
DC-SIGN22 3     Liver/Lymph Node-Specific ICAM-3 Grabbing Non-Integrin2
DC-SIGNR2 3     Mannose Binding C-Type Lectin DC-SIGNR2
L-SIGN2 3     CD209L13

External Ids:    HGNC: 135231   Entrez Gene: 103322   Ensembl: ENSG000001049387   OMIM: 6058725   UniProtKB: Q9H2X33   

Export aliases for CLEC4M gene to outside databases

Previous GC identifers: GC19P007735 GC19P007498


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CLEC4M Gene:
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the
endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and
recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on
public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a
tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting
of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion
receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is
important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity.
Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a
significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function
to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their
ligand-binding properties and distribution. Alternative splicing results in multiple variants.(provided by
RefSeq, Feb 2009)

GeneCards Summary for CLEC4M Gene:
CLEC4M (C-type lectin domain family 4, member M) is a protein-coding gene. Diseases associated with CLEC4M include severe acute respiratory syndrome, and sars infection, protection against. GO annotations related to this gene include peptide antigen binding and receptor activity. An important paralog of this gene is CD207.

UniProtKB/Swiss-Prot: CLC4M_HUMAN, Q9H2X3
Function: Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate
the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a
calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including
HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a
receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS
coronavirus

Gene Wiki entry for CLEC4M Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLEC4M gene promoter:
         ISGF-3   RP58   NRSF form 1   Brachyury   NRSF form 2   Evi-1   ARP-1   FOXO1a   c-Myb   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC4M promoter sequence
   Search Chromatin IP Primers for CLEC4M

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC4M


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13

CLEC4M Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC4M gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P007828:  view genomic region     (about GC identifiers)

Start:
7,828,035 bp from pter      End:
7,834,491 bp from pter
Size:
6,457 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CLC4M_HUMAN, Q9H2X3 (See protein sequence)
Recommended Name: C-type lectin domain family 4 member M  
Size: 399 amino acids; 45350 Da
Subunit: Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120,
ebolavirus glycoproteins, HCV E2, and human SARS coronavirus S protein
Miscellaneous: In vitro, is a receptor for HIV-1 and transmits HIV-1 to permissive T-cells
Sequence caution: Sequence=AAR04559.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
6 PDB 3D structures from and Proteopedia for CLEC4M:
1K9J (3D)        1SL6 (3D)        1XAR (3D)        1XPH (3D)        1Z0Y (3D)        3JQH (3D)    
Secondary accessions: A6NKI4 A8K8B3 Q69F40 Q969M4 Q96QP3 Q96QP4 Q96QP5 Q96QP6 Q9BXS3 Q9H2Q9
Q9H8F0 Q9Y2A8
Alternative splicing: 10 isoforms:  Q9H2X3-1   Q9H2X3-2   Q9H2X3-3   Q9H2X3-4   Q9H2X3-5   Q9H2X3-6   Q9H2X3-7   Q9H2X3-8   
Q9H2X3-9   Q9H2X3-10   (May be due to intron retention)

Explore the universe of human proteins at neXtProt for CLEC4M: NX_Q9H2X3

Explore proteomics data for CLEC4M at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn92, Asn361

  • See CLEC4M Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001138376.1  NP_001138377.1  NP_001138378.1  NP_001138379.1  NP_001138380.1  NP_001138381.1  NP_001138382.1  NP_001138383.1  
    NP_055072.3  

    ENSEMBL proteins: 
     ENSP00000316228   ENSP00000471125   ENSP00000470286   ENSP00000470137   ENSP00000471132  
     ENSP00000470132   ENSP00000377680   ENSP00000248228   ENSP00000335228   ENSP00000351954  
     ENSP00000349924  

    CLEC4M Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CLEC4M (DC-SIGNR/CD299)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CLEC4M
    OriGene Protein Over-expression Lysate for CLEC4M
    OriGene MassSpec for CLEC4M
    OriGene Custom Protein Services for CLEC4M
    GenScript Custom Purified and Recombinant Proteins Services for CLEC4M
    Novus Biologicals CLEC4M Protein
    Novus Biologicals CLEC4M Lysates
    Sino Biological Recombinant Protein for CLEC4M
    Sino Biological Cell Lysate for CLEC4M
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLEC4M

     
    Search eBioscience for Proteins for CLEC4M 

     
    antibodies-online proteins for CLEC4M (5 products) 

     
    antibodies-online peptides for CLEC4M

    CLEC4M Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CLEC4M (DC-SIGNR/CD299)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CLEC4M
    Novus Biologicals CLEC4M Antibodies
    Abcam antibodies for CLEC4M
    Cloud-Clone Corp. Antibodies for CLEC4M
    Search ThermoFisher Antibodies for CLEC4M
    antibodies-online antibodies for CLEC4M (50 products) 

    CLEC4M Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CLEC4M
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLEC4M
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLEC4M
    Cloud-Clone Corp. CLIAs for CLEC4M
    Search eBioscience for ELISAs for CLEC4M 
    antibodies-online kits for CLEC4M (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    CLEC: C-type lectin domain containing

    4 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q9H2X3

    ProtoNet protein and cluster: Q9H2X3

    1 Blocks protein domain: IPB002353 Type II antifreeze protein signature

    UniProtKB/Swiss-Prot: CLC4M_HUMAN, Q9H2X3
    Domain: The tandem repeat domain, also called neck domain, mediates oligomerization
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with CLEC4M           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLC4M_HUMAN, Q9H2X3
    Function: Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate
    the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a
    calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including
    HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a
    receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS
    coronavirus

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity NAS11257134
    GO:0005537mannose binding IEA--
    GO:0030246carbohydrate binding NAS11337487
    GO:0030369ICAM-3 receptor activity NAS11257134
    GO:0042605peptide antigen binding NAS11337487
         
    Find genes that share ontologies with CLEC4M           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd209d):
     homeostasis/metabolism  immune system 

    Find genes that share phenotypes with CLEC4M           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cd209dtm1.1Cfg for CLEC4M

       genOway: Develop your customized and physiologically relevant rodent model for CLEC4M

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CLEC4M using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CLEC4M
    SwitchGear 3'UTR luciferase reporter plasmidCLEC4M 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLEC4M
    Predesigned siRNA for gene silencing in human, mouse, rat CLEC4M

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLEC4M

    Clone
    Products:
         
    OriGene clones in human, mouse for CLEC4M (see all 36)
    OriGene ORF clones in mouse, rat for CLEC4M
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 9): CLEC4M (NM_014257)
    Sino Biological Human cDNA Clone for CLEC4M
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC4M
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4M

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CLEC4M
    Browse ESI BIO Cell Lines and PureStem Progenitors for CLEC4M 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4M


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CLC4M_HUMAN, Q9H2X3: Isoform 1: Cell membrane; Single-pass type II membrane protein (Potential)
    CLC4M_HUMAN, Q9H2X3: Isoform 2: Cell membrane; Single-pass type II membrane protein (Potential)
    CLC4M_HUMAN, Q9H2X3: Isoform 3: Cell membrane; Single-pass type II membrane protein (Potential)
    CLC4M_HUMAN, Q9H2X3: Isoform 5: Secreted (Potential)
    CLC4M_HUMAN, Q9H2X3: Isoform 6: Secreted (Potential)
    CLC4M_HUMAN, Q9H2X3: Isoform 7: Secreted (Potential)
    CLC4M_HUMAN, Q9H2X3: Isoform 10: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm NAS11337487
    GO:0005887integral component of plasma membrane TAS10072769
    GO:0016020membrane TAS11337487

    Find genes that share ontologies with CLEC4M           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CLEC4M About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Measles0.34
    2Tuberculosis
    Tuberculosis
    3Phagosome
    Phagosome


    Find genes that share SuperPaths with CLEC4M           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    3 Kegg Pathways  (Kegg details for CLEC4M):
        Phagosome
    Tuberculosis
    Measles

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLEC4M
    Interactions:

        GeneGlobe Interaction Network for CLEC4M

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for CLEC4M (Q9H2X32, 3 ENSP000003162284) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEACAM1P136882, 3, ENSP000001615594MINT-72826 MINT-72821 I2D: score=1 STRING: ENSP00000161559
    ITGAMP112152, 3, ENSP000002874974MINT-72825 MINT-72823 I2D: score=1 STRING: ENSP00000287497
    CD209Q9NNX63, ENSP000003154774I2D: score=1 STRING: ENSP00000315477
    AP2M1Q96CW13, ENSP000002928074I2D: score=1 STRING: ENSP00000292807
    MMEP084733I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007159leukocyte cell-cell adhesion NAS11337487
    GO:0009988cell-cell recognition TAS11337487
    GO:0019048modulation by virus of host morphology or physiology TAS11337487
    GO:0019062virion attachment to host cell TAS11337487

    Find genes that share ontologies with CLEC4M           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLEC4M (CLC4M)

    1 HMDB Compound for CLEC4M    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 Novoseek inferred chemical compound relationships for CLEC4M gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 58.7 4 11384997 (2), 16210905 (1), 17150970 (1)
    polysaccharide 52.1 9 17621595 (2), 16210905 (1), 11384997 (1), 19249311 (1) (see all 5)
    carbohydrates 26.6 2 18375037 (1)
    galactose 23.9 2 16210905 (1), 14990712 (1)
    allergens 18.2 2 16210905 (1), 20080962 (1)



    Find genes that share compounds with CLEC4M           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CLEC4M gene (11 alternative transcripts): 
    NM_001144904.1  NM_001144905.1  NM_001144906.1  NM_001144907.1  NM_001144908.1  NM_001144909.1  NM_001144910.1  NM_001144911.1  
    NM_014257.4  NM_214675.1  NM_214676.1  

    Unigene Cluster for CLEC4M:

    C-type lectin domain family 4, member M
    Hs.421437  [show with all ESTs]
    Unigene Representative Sequence: NR_026707
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327325(uc002mih.3 uc010xjw.2 uc010dvt.3 uc010dvs.3 uc010xjx.2 uc002mia.3)
    ENST00000596363 ENST00000595751 ENST00000601089 ENST00000596707 ENST00000597522
    ENST00000595496 ENST00000598879 ENST00000599333 ENST00000602143 ENST00000394122(uc002mhy.2)
    ENST00000248228 ENST00000334806 ENST00000359059 ENST00000357361(uc010xjv.1 uc002mhz.3 uc002mic.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLEC4M using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CLEC4M
    SwitchGear 3'UTR luciferase reporter plasmidCLEC4M 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CLEC4M
    Predesigned siRNA for gene silencing in human, mouse, rat CLEC4M
    Clone
    Products:
         
    OriGene clones in human, mouse for CLEC4M (see all 36)
    OriGene ORF clones in mouse, rat for CLEC4M
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 9): CLEC4M (NM_014257)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC4M
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4M
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CLEC4M
    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC4M
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC4M
      QuantiTect SYBR Green Assays in human, mouse, rat CLEC4M
      QuantiFast Probe-based Assays in human, mouse, rat CLEC4M

    Additional mRNA sequence: 

    AB015629.1 AF245219.2 AF290887.1 AK292278.1 AK298084.1 AK304499.1 AK314704.1 AY042234.1 
    AY042235.1 AY042236.1 AY042237.1 AY042238.1 AY042239.1 AY042240.1 AY343913.1 BC038851.1 
    BC110614.2 NR_026707.1 NR_026708.1 NR_026709.1 

    9 DOTS entries:

    DT.113522  DT.100794824  DT.91734204  DT.95302819  DT.100794826  DT.95302830  DT.95302822  DT.113521 
    DT.91734201 

    Selected AceView cDNA sequences (see all 54):

    BC038851 AL544658 AY343913 NM_214679 NM_214677 BQ006101 AA431250 NM_214675 
    AB015629 AV645755 AA779963 AY042234 AY042235 BE562903 BI827055 NM_214676 
    AF245219 NM_214678 AY042236 AF290887 AV645629 AY042239 NM_014257 CB162093 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4M    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8
    SP1:                          -                       -                     
    SP2:                    -                             -                     
    SP3:                                                                        
    SP4:                    -     -                                             
    SP5:              -     -     -                                             


    ECgene alternative splicing isoforms for CLEC4M

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CLEC4M expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTCCATTT
    CLEC4M Expression
    About this image


    CLEC4M expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Sinusoidal Endothelial Cells Sinusoids
             Endothelial-like cells
     
     Liver (Hepatobiliary System)
             Sinusoidal Endothelial Cells Sinusoids
    CLEC4M Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLEC4M Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.421437

    UniProtKB/Swiss-Prot: CLC4M_HUMAN, Q9H2X3
    Tissue specificity: Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found
    in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells

        Custom PCR Arrays for CLEC4M
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CLEC4M
    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC4M
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC4M
    QuantiTect SYBR Green Assays in human, mouse, rat CLEC4M
    QuantiFast Probe-based Assays in human, mouse, rat CLEC4M
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4M

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC4M gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd209d5
    Cd209a1
    CD209d antigen5
    CD209a antigen1
    64.62(n)1
    54.79(a)1
      8 (1.92 cM)5
    1707861  NM_133238.51  NP_573501.11 
     38718245 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1749041 zgc:174904 49.36(n)
    38.93(a)
      564690  NM_001177451.1  NP_001170922.1 


    ENSEMBL Gene Tree for CLEC4M (if available)
    TreeFam Gene Tree for CLEC4M (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CLEC4M gene
    CD2072  CLEC17A2  CLEC4E2  ASGR22  CLEC4F2  CD2092  CLEC4A2  FCER22  
    CLEC10A2  CLEC6A2  ASGR12  CLEC4C2  CLEC4D2  CLEC4G2  
    11 SIMAP similar genes for CLEC4M using alignment to 8 protein entries:     CLC4M_HUMAN (see all proteins):
    CD209    FCER2    CLEC4E    CLEC6A    CLEC4D    CLEC4C
    KLRD1    CLEC5A    CLEC2B    KLRG1    REG4

    Find genes that share paralogs with CLEC4M           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    CLC4M_HUMAN, Q9H2X3: The number of repeats in the tandem repeat domain is shown to vary between 3 and 9 per allele thus
    contributing to a further variability in addition to alternative splicing. The shown 7 repeat-containing form has
    been shown to be the most frequent one (53.9%) in a study with 350 Caucasian individuals


    Selected SNPs for CLEC4M (see all 328)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1482774401,2
    --7765379(+) CAGCTC/TCCTCT 12 -- us2k10--------
    rs1414080471,2
    --7765548(+) CCCCCC/TAACCT 12 -- us2k10--------
    rs1904198031,2
    --7765616(+) CAGATA/GTTTCC 12 -- us2k10--------
    rs1508327651,2
    --7765691(+) CCCACC/TGTTTA 12 -- us2k10--------
    rs1821994651,2
    --7765849(+) ATGGGC/TCAGGC 12 -- us2k10--------
    rs1396087701,2
    --7765915(+) CTTAAC/GGTCAG 12 -- us2k10--------
    rs81089271,2
    C,F,A,H--7765948(+) acatgG/Atgaaa 12 -- us2k18Minor allele frequency- A:0.13NA WA CSA 15
    rs284471271,2
    C--7765954(+) TGAAAA/CCCGTC 12 -- us2k10--------
    rs1401139241,2
    C--7766022(+) CTGCTC/TGGGAG 12 -- us2k10--------
    rs1438128741,2
    C--7766023(+) TGCTCA/GGGAGG 12 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLEC4M (7828035 - 7834491 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CLEC4M:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718107CNV Deletion23290073
    esv1300284CNV Deletion17803354
    esv2718108CNV Deletion23290073
    esv2751809CNV Gain17911159
    nsv833732CNV Gain17160897

    Human Gene Mutation Database (HGMD): CLEC4M
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLEC4M
    DNA2.0 Custom Variant and Variant Library Synthesis for CLEC4M

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605872    OMIM disorders: --

    3 diseases for CLEC4M:    
    About MalaCards
    severe acute respiratory syndrome    sars infection, protection against    intrauterine infections

    1 disease from the University of Copenhagen DISEASES database for CLEC4M:
    Severe acute respiratory syndrome

    Find genes that share disorders with CLEC4M           About GenesLikeMe

    8 Novoseek inferred disease relationships for CLEC4M gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 54.9 17 12502850 (2), 11226297 (2), 11799181 (1), 12477827 (1) (see all 13)
    hepatitis c 42.8 13 19785948 (3), 12634366 (2), 16816373 (2), 15254204 (1) (see all 7)
    virus infection 40.4 5 11739956 (1), 17502670 (1), 20003397 (1), 16051304 (1) (see all 5)
    hiv infections 21.8 6 17530994 (2), 12152166 (2), 19046307 (1), 12738250 (1)
    autoimmunity 17.1 2 16365436 (1)
    infectious disease 16.1 3 16365436 (1), 20003397 (1)
    tuberculosis 4.89 4 17321900 (3)
    aids 0 3 12738250 (3)

    Genetic Association Database (GAD): CLEC4M
    Human Genome Epidemiology (HuGE) Navigator: CLEC4M (19 documents)

    Export disorders for CLEC4M gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CLEC4M gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with CLEC4M)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PubMed id 10072769)1, 2, 3 Yokoyama-Kobayashi M.... Kato S. (Gene 1999)
    2. Functional genetic variants in DC-SIGNR are associated with mother-to-child transmission of HIV-1. (PubMed id 19809496)1, 4, 9 Boily-Larouche G....Roger M. (PLoS ONE 2009)
    3. CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. (PubMed id 15496474)1, 2, 9 Jeffers S.A.... Holmes K.V. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. The neck-region polymorphism of DC-SIGNR in peri-centenarian from Han Chinese population. (PubMed id 20003397)1, 4, 9 Li H....Zhang Y.P. (BMC Med. Genet. 2009)
    5. [DC-SIGNR polymorphisms and its association with HIV-1 infection]. (PubMed id 18841568)1, 4, 9 Wang H....Zhou B. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    6. The polymorphisms in DC-SIGNR affect susceptibility to HIV type 1 infection. (PubMed id 17530994)1, 4, 9 Wichukchinda N....Ariyoshi K. (AIDS Res. Hum. Retroviruses 2007)
    7. The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection. (PubMed id 16364081)1, 4, 9 Nattermann J....Spengler U. (J. Viral Hepat. 2006)
    8. Extensive repertoire of membrane-bound and soluble dendritic cell- specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts. (PubMed id 11337487)1, 2, 9 Mummidi S.... Ahuja S.K. (J. Biol. Chem. 2001)
    9. DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. (PubMed id 11226297)1, 2, 9 Poehlmann S.... Doms R.W. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    10. A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. (PubMed id 11384997)1, 2, 9 Mitchell D.A.... Drickamer K. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10332 HGNC: 13523 AceView: CD209L Ensembl:ENSG00000104938 euGenes: HUgn10332
    ECgene: CLEC4M Kegg: 10332 H-InvDB: CLEC4M

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CLEC4M Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00122

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CLEC4M gene:
    Search GeneIP for patents involving CLEC4M

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CLEC4M (DC-SIGNR/CD299)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for CLEC4M (DC-SIGNR/CD299)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CLEC4M  
     OriGene qPCR primer pairs and template standards for CLEC4M   OriGene Protein Over-expression Lysate for CLEC4M  
     OriGene MassSpec for CLEC4M   OriGene clones in human, mouse for CLEC4M  
     OriGene qSTAR qPCR primer pairs in human, mouse for CLEC4M   OriGene Purified Protein for CLEC4M  
     OriGene ORF clones in mouse, rat for CLEC4M   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLEC4M   OriGene Custom Protein Services for CLEC4M  

     
     
     Block miRNA regulation of human, mouse, rat CLEC4M using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CLEC4M
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC4M Predesigned siRNA for gene silencing in human, mouse, rat CLEC4M
     QuantiFast Probe-based Assays in human, mouse, rat CLEC4M QuantiTect SYBR Green Assays in human, mouse, rat CLEC4M
     Custom PCR Arrays for CLEC4M Search Chromatin IP Primers for CLEC4M
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC4M  GeneGlobe Interaction Network for CLEC4M
     Regulatory tfbs in CLEC4M promoter
     GenScript Custom Purified and Recombinant Proteins Services for CLEC4M GenScript cDNA clones with any tag delivered in your preferred vector for CLEC4M
     GenScript Custom Assay Services for CLEC4M GenScript Custom overexpressing Cell Line Services for CLEC4M
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CLEC4M (CLC4M)
     Proteins for CLEC4M
     Cell Lysates for CLEC4M
     cDNA Clones for CLEC4M
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CLEC4M antibodies
     CLEC4M proteins
     CLEC4M lysates
     Antibodies for CLEC4M
     See all of Abcam's Antibodies, Kits and Proteins for CLEC4M
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CLEC4M
     Antibodies for CLEC4M
     ELISAs for CLEC4M
     CLIAs for CLEC4M



     Browse ESI BIO Cell Lines and PureStem Progenitors for CLEC4M
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4M
     SwitchGear 3'UTR luciferase reporter plasmids for CLEC4M
     SwitchGear Promoter luciferase reporter plasmids for CLEC4M
     Search ThermoFisher Antibodies for CLEC4M
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4M
     Browse compounds at ApexBio
     Search Addgene for plasmids for CLEC4M
      Search eBioscience for proteins for CLEC4M
      Search eBioscience for elisas for CLEC4M
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CLEC4M
     antibodies-online antibodies for CLEC4M (50 products)
     antibodies-online kits for CLEC4M (2 products)
     antibodies-online peptides for CLEC4M
     antibodies-online proteins for CLEC4M (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CLEC4M gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4