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Aliases for CLEC4G Gene

Aliases for CLEC4G Gene

  • C-Type Lectin Domain Family 4, Member G 2 3
  • C-Type Lectin Superfamily 4, Member G 2 3
  • Liver And Lymph Node Sinusoidal Endothelial Cell C-Type Lectin 3
  • C-Type Lectin Domain Family 4 Member G 3
  • DTTR431 3
  • LSECtin 3
  • LP2698 3
  • UNQ431 3

External Ids for CLEC4G Gene

Previous GeneCards Identifiers for CLEC4G Gene

  • GC19M007703
  • GC19M007463

Summaries for CLEC4G Gene

Entrez Gene Summary for CLEC4G Gene

  • This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for CLEC4G Gene

CLEC4G (C-Type Lectin Domain Family 4, Member G) is a Protein Coding gene. Diseases associated with CLEC4G include lassa fever. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC4D.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC4G Gene

Genomics for CLEC4G Gene

Regulatory Elements for CLEC4G Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLEC4G Gene

Start:
7,728,957 bp from pter
End:
7,733,906 bp from pter
Size:
4,950 bases
Orientation:
Minus strand

Genomic View for CLEC4G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC4G Gene

Proteins for CLEC4G Gene

  • Protein details for CLEC4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXB4-CLC4G_HUMAN
    Recommended name:
    C-type lectin domain family 4 member G
    Protein Accession:
    Q6UXB4
    Secondary Accessions:

    Protein attributes for CLEC4G Gene

    Size:
    293 amino acids
    Molecular mass:
    32562 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC4G Gene

Proteomics data for CLEC4G Gene at MOPED

Post-translational modifications for CLEC4G Gene

  • Glycosylation at Asn73 and Asn159
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC4G Gene

No data available for DME Specific Peptides for CLEC4G Gene

Domains for CLEC4G Gene

Gene Families for CLEC4G Gene

HGNC:
  • CLEC :C-type lectin domain containing

Suggested Antigen Peptide Sequences for CLEC4G Gene

Graphical View of Domain Structure for InterPro Entry

Q6UXB4

UniProtKB/Swiss-Prot:

CLC4G_HUMAN :
  • Q6UXB4
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC4G: view

Function for CLEC4G Gene

Gene Ontology (GO) - Molecular Function for CLEC4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18624398
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC4G: view
genes like me logo Genes that share phenotypes with CLEC4G: view

Animal Models for CLEC4G Gene

MGI Knock Outs for CLEC4G:

Animal Model Products

CRISPR Products

miRNA for CLEC4G Gene

miRTarBase miRNAs that target CLEC4G

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC4G

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CLEC4G Gene

Localization for CLEC4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC4G Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC4G Gene COMPARTMENTS Subcellular localization image for CLEC4G gene
Compartment Confidence
plasma membrane 3
extracellular 2
nucleus 2
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLEC4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC4G: view

Pathways for CLEC4G Gene

SuperPathways for CLEC4G Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLEC4G Gene

None

No data available for Pathways by source for CLEC4G Gene

Compounds for CLEC4G Gene

(1) Novoseek inferred chemical compound relationships for CLEC4G Gene

Compound -log(P) Hits PubMed IDs
mannan 67.9 2
genes like me logo Genes that share compounds with CLEC4G: view

Transcripts for CLEC4G Gene

mRNA/cDNA for CLEC4G Gene

(14) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC4G Gene

C-type lectin domain family 4, member G:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC4G

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CLEC4G

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4G Gene

No ASD Table

Relevant External Links for CLEC4G Gene

GeneLoc Exon Structure for
CLEC4G
ECgene alternative splicing isoforms for
CLEC4G

Expression for CLEC4G Gene

mRNA expression in normal human tissues for CLEC4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC4G Gene

This gene is overexpressed in Liver (14.6), Brain - Cerebellum (6.9), and Brain - Cerebellar Hemisphere (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLEC4G Gene

SOURCE GeneReport for Unigene cluster for CLEC4G Gene Hs.220649

genes like me logo Genes that share expressions with CLEC4G: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CLEC4G Gene

Orthologs for CLEC4G Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC4G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC4G 35
  • 96.5 (n)
  • 94.41 (a)
CLEC4G 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLEC4G 35
  • 79.43 (n)
  • 71.03 (a)
CLEC4G 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC4G 35
  • 79.98 (n)
  • 70.65 (a)
CLEC4G 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec4g 35
  • 73.83 (n)
  • 64.16 (a)
Clec4g 16
Clec4g 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLEC4G 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Clec4g 35
  • 75.24 (n)
  • 64.9 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
OneToMany
Species with no ortholog for CLEC4G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC4G Gene

ENSEMBL:
Gene Tree for CLEC4G (if available)
TreeFam:
Gene Tree for CLEC4G (if available)

Paralogs for CLEC4G Gene

Selected SIMAP similar genes for CLEC4G Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CLEC4G Gene

genes like me logo Genes that share paralogs with CLEC4G: view

Variants for CLEC4G Gene

Sequence variations from dbSNP and Humsavar for CLEC4G Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1010046 -- 7,728,898(-) CGTAC(A/G)AGTGA downstream-variant-500B
rs1010047 -- 7,728,616(-) AAGGG(C/T)CACCT downstream-variant-500B
rs1363770 -- 7,732,822(+) CGACA(C/T)GGAAG upstream-variant-2KB
rs1363771 -- 7,732,890(+) CATTT(C/T)TGAAA upstream-variant-2KB
rs1363772 -- 7,732,939(+) CAAAA(A/T)TTGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLEC4G Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV Gain 17911159
nsv833731 CNV Loss 17160897
nsv833732 CNV Gain 17160897

Relevant External Links for CLEC4G Gene

HapMap Linkage Disequilibrium report
CLEC4G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC4G Gene

Disorders for CLEC4G Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CLEC4G Gene including...

Search for CLEC4G Gene in MalaCards »

(1) University of Copenhagen DISEASES for CLEC4G Gene

Relevant External Links for CLEC4G

Genetic Association Database (GAD)
CLEC4G
Human Genome Epidemiology (HuGE) Navigator
CLEC4G
genes like me logo Genes that share disorders with CLEC4G: view

No data available for UniProtKB/Swiss-Prot for CLEC4G Gene

Publications for CLEC4G Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node. (PMID: 14711836) Liu W. … He F. (J. Biol. Chem. 2004) 3 23
  4. The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells. (PMID: 17339424) Dominguez-Soto A. … Corbi A.L. (Blood 2007) 3 23
  5. Interactions of LSECtin and DC-SIGN/DC-SIGNR with viral ligands: Differential pH dependence, internalization and virion binding. (PMID: 18083206) Gramberg T. … PAPhlmann S. (Virology 2008) 3 23

Products for CLEC4G Gene

  • antibodies-online peptides for CLEC4G
  • antibodies-online antibodies for CLEC4G
  • antibodies-online kits for CLEC4G

Sources for CLEC4G Gene

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