CLEC4G Gene
protein-coding GIFtS: 48
GCID: GC19M007793
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C-type lectin domain family 4, member G(Previous names: C-type lectin superfamily 4, member G )
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Aliases for CLEC4G gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| C-Type Lectin Domain Family 4, Member G1 2 | | DTTR4312 | | LSECtin1 2 | | LP26982 | | UNQ4311 2 | | C-Type Lectin Domain Family 4 Member G2 | | C-Type Lectin Superfamily 4, Member G1 2 | | Liver And Lymph Node Sinusoidal Endothelial Cell C-Type Lectin2 |
Export aliases for CLEC4G gene to outside databasesPrevious GC identifers: GC19M007703 GC19M007463 |
Summaries for CLEC4G gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for CLEC4G: This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cellimmune response. Multiple transcript variants encoding different isoforms have been found for this gene. (provided byRefSeq, Oct 2011)
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Genomic Views for CLEC4G gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_077812.2
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CLEC4G gene promoter: Oct-B1 RP58 RFX1 oct-B3 oct-B2 POU2F1 POU2F1a ARP-1 FOXO1a FOXO1 Other transcription factors
Search SABiosciences Chromatin IP Primers for CLEC4G
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC4G |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2CLEC4G Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M007793: view genomic region
(about GC identifiers)
Start:
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7,793,843 bp from pter |
End:
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7,797,057 bp from pter |
Size:
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3,215 bases |
Orientation:
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minus strand |
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Proteins for CLEC4G gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: CLC4G_HUMAN, Q6UXB4 (See
protein sequence)Recommended Name: C-type lectin domain family 4 member G Size: 293 amino acids; 32562 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)Explore the universe of human proteins at neXtProt for CLEC4G: NX_Q6UXB4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UXB4 CLEC4G Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (2 alternative transcripts):
NP_001231785.1 NP_940894.1 ENSEMBL proteins: ENSP00000327599 Human Recombinant Protein Products for CLEC4G:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
CLEC4G for ontologies About GeneDecksing
CLEC4G Antibody Products: Assay Products for CLEC4G: |
Protein
Domains / Families for CLEC4G gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLEC4G for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UXB4ProtoNet protein and cluster: Q6UXB4 1 Blocks protein family: IPB002353 Type II antifreeze protein signature
UniProtKB/Swiss-Prot: CLC4G_HUMAN, Q6UXB4Similarity: Contains 1 C-type lectin domain |
Function for CLEC4G gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CLEC4G for ontologies About GeneDecksing
Phenotypes: 1 MGI phenotypic allele for Clec4g (no phenotypes)
CLEC4G for phenotypes About GeneDecksing
Animal Models: Mouse knock-out Clec4gtm1.1Cfg for CLEC4G
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4G (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4G OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CLEC4G (NM_198492) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLEC4G | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4G  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4G |
|
Pathways & Interactions for CLEC4G gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC4G
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
 5/26 Interacting proteins for CLEC4G (Q6UXB41, 3 ENSP000003275994) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
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Drugs & Compounds for CLEC4G gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CLEC4G for compounds About GeneDecksing
Browse Tocris compounds for CLEC4G 1 Novoseek chemical compound relationship for CLEC4G gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mannan |
67.9 |
5 |
17339424 (1), 16051304 (1) |
Search CenterWatch for drugs/clinical trials and news about CLEC4G / CLC4G 
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Transcripts for CLEC4G gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for CLEC4G gene (2 alternative transcripts): NM_001244856.1 NM_198492.3 Unigene Cluster for CLEC4G: C-type lectin domain family 4, member G Hs.220649 [show with all ESTs]Unigene Representative Sequence: AY4237061 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000328853(uc021uny.1 uc002mhp.4)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4G (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4G OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CLEC4G (NM_198492) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLEC4G | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4G  |
Additional cDNA sequence: AY203939.1 AY358431.1 AY423706.1 BC039679.1 BC093691.1 BC093693.1 BC143309.1 3 DOTS entries: DT.440549 DT.101986269 DT.121445402 14 AceView cDNA sequences: CB147273 BC039679 BX113493 R96439 BF512603 AY203939 BI757731 BG010310 NM_198492 BI755445 AY358431 AA774984 BU784074 CB998191 GeneLoc Exon Structure
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Expression for CLEC4G gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLEC4G expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CCGACCTCAT
 About this image See CLEC4G Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CLEC4G
SOURCE GeneReport for Unigene cluster: Hs.220649 SABiosciences Custom PCR Arrays for CLEC4G
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC4G Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC4G | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC4G | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC4G | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4G |
Orthologs for CLEC4G gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CLEC4G gene from 2/10 species (see all 10) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
lizard (Anolis carolinensis) |
Reptilia |
CLEC17A6 |
-- |
33(a) |
1 ↔ 1 |
2(102766152-102769827) |
zebrafish (Danio rerio) |
Actinopterygii |
si:ch211-170d8.56si:ch211-170d8.86 |
si:ch211-170d8.8 |
21(a)21(a) |
possible orthologpossible ortholog |
8(41685924-41692286) 8(41695385-41707267) |
ENSEMBL Gene Tree for CLEC4G (if available) TreeFam Gene Tree for CLEC4G (if available)  |
Paralogs for CLEC4G gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for CLEC4G gene
- CD2072 CLEC4E2 ASGR22 CLEC4M2 CLEC4F2 CD2092 CLEC10A2 FCER22
- CLEC4A2 CLEC6A2 ASGR12 CLEC4C2 CLEC4D2
2 SIMAP similar genes for CLEC4G using alignment to 3 protein entries: CLC4G_HUMAN (see all proteins):CLEC2B FCER2
CLEC4G for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CLEC4G PGOHUM00000263008
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Genomic Variants for CLEC4G gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 19 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for CLEC4G (7793843 - 7797057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for CLEC4G 1 CNV: 8863  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC4G |
|
Disorders
/ Diseases for CLEC4G gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLEC4G for disorders About GeneDecksing
4 diseases for CLEC4G: About MalaCardslassa fever severe acute respiratory syndrome hepatitis b hepatitis 1 disease from the University of Copenhagen DISEASES database for CLEC4G:Lassa fever Human Genome Epidemiology (HuGE) Navigator: CLEC4G (2 documents) Export disorders for CLEC4G gene to outside databases
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Publications for CLEC4G gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLEC4G gene, integrated from 9 sources (see all 20): (articles sorted by number of sources associating them with CLEC4G) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DC-SIGN family member LSECtin is a novel ligand o f CD44 on activated T cells. (PubMed id 20127679)1, 9 Tang L....He F. (2010)
- The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells. (PubMed id 17339424)1, 9 Dominguez-Soto A....Corbi A.L. (2007)
- The pathogen receptor liver and lymph node sinusoidal endotelial cell C-type lectin is expressed in human Kupffer cells and regulated by PU.1. (PubMed id 19111020)1, 9 DomA-nguez-Soto A....CorbA- A.L. (2009)
- Interactions of LSECtin and DC-SIGN/DC-SIGNR with viral ligands: Differential pH dependence, internalization and virion binding. (PubMed id 18083206)1, 9 Gramberg T....Pohlmann S. (2008)
- Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node. (PubMed id 14711836)1, 9 Liu W....He F. (2004)
- Identification of cell surface molecules involved in d ystroglycan-independent Lassa virus cell entry. (PubMed id 22156524)1 Shimojima M....Kawaoka Y. (2012)
- Use of (alternative) coreceptors for HIV entry. (PubMed id 22842622)1 Pollakis G. and Paxton W.A. (2012)
- Mobility study of individual residue sites in the carb ohydrate recognition domain of LSECtin using SDSL-EPR technique. (PubMed id 22711492)1 Wang C....Wu K. (2012)
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External Searches for CLEC4G gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing CLEC4G gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLEC4G gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLEC4G gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for CLEC4G | Pharmacogenomics, SNPs, Pathways | | Functional Glycomics Gateway - Glycan Binding | http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_416 |
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About This Section
| Patent Information for CLEC4G gene: Search GeneIP for patents involving CLEC4G
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for CLEC4G gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for CLEC4G | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC4G | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC4G | | OriGene Protein Over-expression Lysate for CLEC4G | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for CLEC4G | | OriGene 3'-UTR Clone for CLEC4G | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4G | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4G | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for CLEC4G | | OriGene Custom Protein Services for CLEC4G | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLEC4G | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC4G | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC4G | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC4G | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC4G | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC4G |
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| | | Search Tocris compounds for CLEC4G |
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 | | CLEC4G Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4G |
|  |  |  |  | | | Search ThermoFisher Antibodies for CLEC4G |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4G |
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