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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CLEC4F Gene

protein-coding GIFtS: 45
GCID: GC02M071035

C-type lectin domain family 4, member F

(Previous names: C-type (calcium dependent, carbohydrate-recognition domain)...)
(Previous symbol: CLECSF13)

Explore 1 disease affiliated with
CLEC4F via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 4, Member F¹ ²		C-Type Lectin 13² ³
CLECSF13¹ ² ³		C-Type Lectin Superfamily Member 13² ³
KCLR¹ ²		FLJ39110¹
C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 13¹ ²		C-Type Lectin Domain Family 4 Member F²

External Ids:	HGNC: 25357¹	Entrez Gene: 165530²	Ensembl: ENSG00000152672⁷	UniProtKB: Q8N1N0³

Export aliases for CLEC4F gene to outside databases

Previous GC identifers: GC02M070948 GC02M070889 GC02M070772

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CLC4F_HUMAN, Q8N1N0

Function: Receptor with an affinity for galactose and fucose. Could be involved in endocytosis (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CLEC4F gene promoter:
HNF-4alpha2 Tal-1beta E4BP4 E47 HNF-4alpha1 SRY POU2F1 POU2F1a ZID LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLEC4F promoter sequence

Search SABiosciences Chromatin IP Primers for CLEC4F

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC4F

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3 Ensembl cytogenetic band: 2p13.3 HGNC cytogenetic band: 2p13.3

CLEC4F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC4F gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M071035: view genomic region (about GC identifiers)

Start:	71,035,775 bp from pter	End:	71,047,732 bp from pter
Size:	11,958 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLC4F_HUMAN, Q8N1N0 (See protein sequence)

Recommended Name: C-type lectin domain family 4 member F

Size: 589 amino acids; 65519 Da

Subcellular location: Membrane; Single-pass type II membrane protein (By similarity)

Sequence caution: Sequence=BAC04786.1; Type=Erroneous termination; Positions=540; Note=Translated as Trp;

Explore the universe of human proteins at neXtProt for CLEC4F: NX_Q8N1N0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N1N0

CLEC4F Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001244956.1 NP_775806.2

ENSEMBL proteins:

ENSP00000272367 ENSP00000390581

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	Uscn Proteins for CLEC4F

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

CLEC4F for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CLEC4F for domains About GeneDecksing

3 InterPro domains/families:

IPR016187 C-type_lectin_fold

IPR016186 C-type_lectin-like

IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry Q8N1N0

ProtoNet protein and cluster: Q8N1N0

UniProtKB/Swiss-Prot: CLC4F_HUMAN, Q8N1N0

Similarity: Contains 1 C-type lectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CLC4F_HUMAN, Q8N1N0

Function: Receptor with an affinity for galactose and fucose. Could be involved in endocytosis (By similarity)

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In Situ Assay
Products:

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0030246	carbohydrate binding	IEA	--

CLEC4F for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CLEC4F

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for CLEC4F (Q8N1N0^{2, 3} ENSP00000272367⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253²^,³, ENSP00000244769⁴	MINT-2879054 MINT-2879073 I2D: score=3 STRING: ENSP00000244769

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006897	endocytosis	IEA	--

CLEC4F for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLEC4F
Search CenterWatch for drugs/clinical trials and news about CLEC4F / CLC4F

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for CLEC4F gene (2 alternative transcripts):

NM_001258027.1 NM_173535.2

Unigene Cluster for CLEC4F:

C-type lectin domain family 4, member F

Hs.681239 [show with all ESTs]

Unigene Representative Sequence: NM_173535

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000272367(uc002shf.3 uc010yqv.1) ENST00000426626

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		hsa-miR-186* hsa-miR-3176 hsa-miR-1224-5p hsa-miR-103a-2* hsa-miR-3922-3p
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC4F

Additional cDNA sequence:

AK096429.1 AK301242.1 BC139723.1 BC144652.1

1 DOTS entry:

DT.100017310

8 AceView cDNA sequences:

BU740367 BM720443 NM_173535 AK096429 CK003546 BM725640 BU739898 CD701685

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLEC4F expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCAGGGTG

About this image

CLEC4F expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CLEC4F Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLEC4F

SOURCE GeneReport for Unigene cluster: Hs.681239

SABiosciences Custom PCR Arrays for CLEC4F

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4F

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CLEC4F gene from 2/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	34(a) 31(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343540.1(119657-124514) GL343830.1(152731-155973)
zebrafish (Danio rerio)	Actinopterygii	si:ch211-170d8.8⁶ si:ch211-170d8.5⁶	si:ch211-170d8.5	19(a) 17(a)	possible ortholog possible ortholog	8(41695385-41707267) 8(41685924-41692286)

ENSEMBL Gene Tree for CLEC4F (if available)
TreeFam Gene Tree for CLEC4F (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CLEC4F gene

CD207² CLEC4E² ASGR2² CLEC4M² CD209² CLEC10A² FCER2² CLEC4A²

CLEC6A² ASGR1² CLEC4C² CLEC4D² CLEC4G²

1 SIMAP similar gene for CLEC4F using alignment to 3 protein entries: CLC4F_HUMAN (see all proteins):

CD207

CLEC4F for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CLEC4F
PGOHUM00000250430

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs59923790^1,2	C,	--	71035335(+)	`CACTTC/TGGCAG`	2	--	int¹ ds500¹		1		WA	2
rs193191766^1,2		--	71035384(+)	`AACAGA/CCTGGC`	2	--	ds500¹ int¹		0	--	--	--	--
rs78869999^1,2	C,	--	71035392(+)	`GGCCAG/ACATGG`	2	--	int¹ ds500¹		1		CSA	2
rs111243048^1,2		--	71035600(+)	`AGTCCC/TTGTAG`	2	--	ds500¹ int¹		1		CSA	2
rs144728174^1,2		--	71035617(+)	`TTCAAC/TCTCTG`	2	--	int¹ ds500¹		0	--	--	--	--
rs187224887^1,2		--	71035709(+)	`TGAGGA/GAAGGA`	2	--	ds500¹ int¹		0	--	--	--	--
rs191252516^1,2		--	71035776(+)	`AAGCTG/TTTGTT`	2	--	ut3¹		0	--	--	--	--
rs183779792^1,2		--	71035928(+)	`GAATCA/GAAGAA`	2	--	ut3¹		0	--	--	--	--
rs147792663^1,2	C,	--	71035951(+)	`TCCAC-/AAGGCC`	2	--	ut3¹		0	--	--	--	--
rs141894191^1,2		--	71036003(+)	`AAGGCA/TTCGAG`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CLEC4F (71035775 - 71047732 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLEC4F: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC4F

DNA2.0 Custom Variant and Variant Library Synthesis for CLEC4F

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CLEC4F for disorders About GeneDecksing

1 disease for CLEC4F: About MalaCards

ataxia

Export disorders for CLEC4F gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CLEC4F gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLEC4F)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)^{1, 3} Bonaldo M.F.... Soares M.B. (1996)
Structure of the gene for a carbohydrate-binding receptor unique to rat kupffer cells. (PubMed id 1846367)^{1, 3} Hoyle G.W. and Hill R.L. (1991)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 165530	HGNC: 25357	AceView: CLECSF13	Ensembl:ENSG00000152672	euGenes: HUgn165530
ECgene: CLEC4F	H-InvDB: CLEC4F

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CLEC4F	Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00114

Intellectual Property for CLEC4F gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CLEC4F gene:
Search GeneIP for patents involving CLEC4F

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	OriGene Custom Antibody Services for CLEC4F		OriGene Custom Protein Services for CLEC4F
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLEC4F
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	GenScript Custom Purified and Recombinant Proteins Services for CLEC4F		GenScript cDNA clones with any tag delivered in your preferred vector for CLEC4F
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CLEC4F gene at Home site.

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CLEC4F Gene

C-type lectin domain family 4, member F

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CLEC4F Gene

C-type lectin domain family 4, member F

Aliasesfor CLEC4F gene

Summariesfor CLEC4F gene

Genomic Viewsfor CLEC4F gene

Proteinsfor CLEC4F gene

Protein Domains /Familiesfor CLEC4F gene

Functionfor CLEC4F gene

Pathways & Interactionsfor CLEC4F gene

Drugs & Compoundsfor CLEC4F gene

Transcriptsfor CLEC4F gene

Expression for CLEC4F gene

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Genomic Variantsfor CLEC4F gene

Disorders / Diseasesfor CLEC4F gene

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External Searches for CLEC4F gene

Genome Databases showing CLEC4F gene

Other Databases showing CLEC4F gene

Specialized Databases showing CLEC4F gene

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Aliases
for CLEC4F gene

Summaries
for CLEC4F gene

Genomic Views
for CLEC4F gene

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for CLEC4F gene

Protein Domains /
Families
for CLEC4F gene

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for CLEC4F gene

Pathways & Interactions
for CLEC4F gene

Drugs & Compounds
for CLEC4F gene

Transcripts
for CLEC4F gene

Expression
for CLEC4F gene

Orthologs
for CLEC4F gene

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for CLEC4F gene

Genomic Variants
for CLEC4F gene

Disorders / Diseases
for CLEC4F gene

Publications
for CLEC4F gene

Intellectual Property
for CLEC4F gene

Products
for CLEC4F gene