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Aliases for CLEC4E Gene

Aliases for CLEC4E Gene

  • C-Type Lectin Domain Family 4 Member E 2 3 5
  • Macrophage-Inducible C-Type Lectin 2 3 4
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 9 2 3
  • C-Type Lectin Domain Family 4, Member E 2 3
  • C-Type Lectin Superfamily Member 9 3 4
  • CLECSF9 3 4
  • MINCLE 3 4

External Ids for CLEC4E Gene

Previous HGNC Symbols for CLEC4E Gene

  • CLECSF9

Previous GeneCards Identifiers for CLEC4E Gene

  • GC12M008578
  • GC12M008685
  • GC12M008468

Summaries for CLEC4E Gene

Entrez Gene Summary for CLEC4E Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLEC4E Gene

CLEC4E (C-Type Lectin Domain Family 4 Member E) is a Protein Coding gene. Among its related pathways are Immune System and CLEC7A (Dectin-1) signaling. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is CLEC6A.

UniProtKB/Swiss-Prot for CLEC4E Gene

  • C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC4E Gene

Genomics for CLEC4E Gene

Regulatory Elements for CLEC4E Gene

Promoters for CLEC4E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLEC4E on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC4E Gene

Chromosome:
12
Start:
8,533,305 bp from pter
End:
8,540,963 bp from pter
Size:
7,659 bases
Orientation:
Minus strand

Genomic View for CLEC4E Gene

Genes around CLEC4E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC4E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC4E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC4E Gene

Proteins for CLEC4E Gene

  • Protein details for CLEC4E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULY5-CLC4E_HUMAN
    Recommended name:
    C-type lectin domain family 4 member E
    Protein Accession:
    Q9ULY5
    Secondary Accessions:
    • B2R6Q6

    Protein attributes for CLEC4E Gene

    Size:
    219 amino acids
    Molecular mass:
    25073 Da
    Quaternary structure:
    • Monomer. Homodimer.

    Three dimensional structures from OCA and Proteopedia for CLEC4E Gene

neXtProt entry for CLEC4E Gene

Proteomics data for CLEC4E Gene at MOPED

Post-translational modifications for CLEC4E Gene

  • Glycosylation at Asn 62 and Asn 107
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC4E Gene

No data available for DME Specific Peptides for CLEC4E Gene

Domains & Families for CLEC4E Gene

Gene Families for CLEC4E Gene

Protein Domains for CLEC4E Gene

Suggested Antigen Peptide Sequences for CLEC4E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULY5

UniProtKB/Swiss-Prot:

CLC4E_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC4E: view

Function for CLEC4E Gene

Molecular function for CLEC4E Gene

UniProtKB/Swiss-Prot Function:
C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
genes like me logo Genes that share phenotypes with CLEC4E: view

Animal Models for CLEC4E Gene

MGI Knock Outs for CLEC4E:

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC4E

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLEC4E Gene

Localization for CLEC4E Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC4E Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC4E Gene COMPARTMENTS Subcellular localization image for CLEC4E gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CLEC4E Gene

Pathways & Interactions for CLEC4E Gene

genes like me logo Genes that share pathways with CLEC4E: view

Pathways by source for CLEC4E Gene

1 KEGG pathway for CLEC4E Gene

Interacting Proteins for CLEC4E Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000299663%0d%0a9606.ENSP00000289902%0d%0a9606.ENSP00000364898%0d%0a
Selected Interacting proteins: ENSP00000299663 for CLEC4E Gene via STRING

Gene Ontology (GO) - Biological Process for CLEC4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0038094 Fc-gamma receptor signaling pathway IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with CLEC4E: view

No data available for SIGNOR curated interactions for CLEC4E Gene

Drugs & Compounds for CLEC4E Gene

No Compound Related Data Available

Transcripts for CLEC4E Gene

Unigene Clusters for CLEC4E Gene

C-type lectin domain family 4, member E:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4E Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for CLEC4E Gene

GeneLoc Exon Structure for
CLEC4E
ECgene alternative splicing isoforms for
CLEC4E

Expression for CLEC4E Gene

mRNA expression in normal human tissues for CLEC4E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC4E Gene

This gene is overexpressed in Whole Blood (x41.9).

SOURCE GeneReport for Unigene cluster for CLEC4E Gene Hs.236516

genes like me logo Genes that share expression patterns with CLEC4E: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CLEC4E Gene

Orthologs for CLEC4E Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC4E Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLEC4E 35
  • 84.47 (n)
  • 75.24 (a)
CLEC4E 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC4E 35
  • 82.94 (n)
  • 72.99 (a)
CLEC4E 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec4e 35
  • 79.5 (n)
  • 67.14 (a)
Clec4e 16
Clec4e 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLEC4E 35
  • 99.54 (n)
  • 98.63 (a)
CLEC4E 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clec4e 35
  • 79.91 (n)
  • 68.22 (a)
oppossum
(Monodelphis domestica)
Mammalia CLEC4E 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLEC4E 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-154o6.6 35
  • 53.08 (n)
  • 43.85 (a)
Species with no ortholog for CLEC4E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLEC4E Gene

ENSEMBL:
Gene Tree for CLEC4E (if available)
TreeFam:
Gene Tree for CLEC4E (if available)

Paralogs for CLEC4E Gene

(16) SIMAP similar genes for CLEC4E Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CLEC4E: view

Variants for CLEC4E Gene

Sequence variations from dbSNP and Humsavar for CLEC4E Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4551822 -- 8,538,109(+) cagac(A/C/T)ggaaa intron-variant
rs4562874 -- 8,538,646(+) ctctc(A/G)tctct intron-variant
rs4242896 -- 8,536,403(+) GTATA(A/C/G)AAAAA intron-variant
rs4620776 -- 8,540,737(+) GGAAG(A/C/G)AAAGG intron-variant
rs5014225 -- 8,540,644(+) CTGTC(A/C)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC4E Gene

Variant ID Type Subtype PubMed ID
nsv898737 CNV Loss 21882294

Variation tolerance for CLEC4E Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC4E Gene

HapMap Linkage Disequilibrium report
CLEC4E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC4E Gene

Disorders for CLEC4E Gene

Relevant External Links for CLEC4E

Human Genome Epidemiology (HuGE) Navigator
CLEC4E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC4E

No disorders were found for CLEC4E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC4E Gene

Publications for CLEC4E Gene

  1. A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages. (PMID: 10528209) Matsumoto M. … Akira S. (J. Immunol. 1999) 2 3 4 67
  2. Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans. (PMID: 18509109) Bugarcic A. … Blanchard H. (Glycobiology 2008) 3 23
  3. Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity. (PMID: 24721577) Wevers B.A. … Gringhuis S.I. (Cell Host Microbe 2014) 3
  4. Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle. (PMID: 24733387) Hattori Y. … Sugita M. (J. Biol. Chem. 2014) 3
  5. Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL. (PMID: 24101491) Furukawa A. … Maenaka K. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3

Products for CLEC4E Gene

Sources for CLEC4E Gene

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