Aliases for CLEC4E Gene
External Ids for CLEC4E Gene
Previous HGNC Symbols for CLEC4E Gene
Previous GeneCards Identifiers for CLEC4E Gene
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLEC4E Gene
CLEC4E (C-Type Lectin Domain Family 4 Member E) is a Protein Coding gene. Diseases associated with CLEC4E include Common Wart. Among its related pathways are Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) and Tuberculosis. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is CLEC4C.
UniProtKB/Swiss-Prot for CLEC4E Gene
C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.