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CLEC4E Gene

protein-coding   GIFtS: 52
GCID: GC12M008685

C-Type Lectin Domain Family 4, Member E

(Previous names: C-type (calcium dependent, carbohydrate-recognition domain)...)
(Previous symbol: CLECSF9)
  See CLEC4E-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C-Type Lectin Domain Family 4, Member E1 2     Macrophage-Inducible C-Type Lectin2 3
CLECSF91 2 3     C-Type Lectin Superfamily Member 92 3
MINCLE2 3 5     C-Type Lectin Domain Family 4 Member E2
C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin,
Superfamily Member 91 2
     

External Ids:    HGNC: 145551   Entrez Gene: 262532   Ensembl: ENSG000001665237   OMIM: 6099625   UniProtKB: Q9ULY53   

Export aliases for CLEC4E gene to outside databases

Previous GC identifers: GC12M008578 GC12M008468


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLEC4E Gene:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this
family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling,
glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein
is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in
inflammation. Alternative splice variants have been described but their full-length sequence has not been
determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural
killer gene complex region. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLEC4E Gene:
CLEC4E (C-type lectin domain family 4, member E) is a protein-coding gene. Diseases associated with CLEC4E include chromoblastomycosis. GO annotations related to this gene include carbohydrate binding and receptor activity. An important paralog of this gene is CD207.

UniProtKB/Swiss-Prot: CLC4E_HUMAN, Q9ULY5
Function: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged
cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The
detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes
alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein,
that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc
receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK,
CARD9 and NF-kappa-B




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLEC4E gene promoter:
         AREB6   MEF-2A   PPAR-gamma1   SRY   POU2F1   POU2F1a   Cart-1   aMEF-2   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC4E promoter sequence
   Search Chromatin IP Primers for CLEC4E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC4E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

CLEC4E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC4E gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M008685:  view genomic region     (about GC identifiers)

Start:
8,685,901 bp from pter      End:
8,693,559 bp from pter
Size:
7,659 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLC4E_HUMAN, Q9ULY5 (See protein sequence)
Recommended Name: C-type lectin domain family 4 member E  
Size: 219 amino acids; 25073 Da
Subunit: Monomer. Homodimer
2 PDB 3D structures from and Proteopedia for CLEC4E:
3WH2 (3D)        3WH3 (3D)    
Secondary accessions: B2R6Q6

Explore the universe of human proteins at neXtProt for CLEC4E: NX_Q9ULY5

Post-translational modifications: 

  • Glycosylation2 at Asn62, Asn107
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_055173.1  
    ENSEMBL proteins: 
     ENSP00000299663   ENSP00000387737   ENSP00000443034   ENSP00000443328   ENSP00000404994  

    CLEC4E Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q9ULY5

    ProtoNet protein and cluster: Q9ULY5

    1 Blocks protein domain: IPB002353 Type II antifreeze protein signature

    UniProtKB/Swiss-Prot: CLC4E_HUMAN, Q9ULY5
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with CLEC4E           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLC4E_HUMAN, Q9ULY5
    Function: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged
    cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The
    detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes
    alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein,
    that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc
    receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK,
    CARD9 and NF-kappa-B

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with CLEC4E           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Clec4e):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis 

    Find genes that share phenotypes with CLEC4E           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CLEC4E: Clec4etm1.1Cfg Clec4etm1Tks Clec4etm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLEC4E
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC4E
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLEC4E

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CLEC4E:
    hsa-miR-4324 hsa-miR-302f
    SwitchGear 3'UTR luciferase reporter plasmidCLEC4E 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for CLEC4E
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4E

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4E


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLC4E_HUMAN, Q9ULY5: Membrane; Single-pass type II membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CLEC4E           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLEC4E About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    2Tuberculosis
    Tuberculosis


    Find genes that share SuperPaths with CLEC4E           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CLEC4E
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways




    1 Kegg Pathway  (Kegg details for CLEC4E):
        Tuberculosis

        Pathway & Disease-focused RT2 Profiler PCR Array including CLEC4E: 
              Toll-Like Receptor Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CLEC4E

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CLEC4E (ENSP000002996634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCER1GENSP000002899024STRING: ENSP00000289902
    SYKENSP000003648984STRING: ENSP00000364898
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0050715positive regulation of cytokine secretion IEA--

    Find genes that share ontologies with CLEC4E           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLEC4E (CLC4E)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLEC4E gene: 
    NM_014358.2  

    Unigene Cluster for CLEC4E:

    C-type lectin domain family 4, member E
    Hs.236516  [show with all ESTs]
    Unigene Representative Sequence: NM_014358
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299663(uc001quo.1) ENST00000446457 ENST00000545274 ENST00000537698
    ENST00000450725 ENST00000446809
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CLEC4E:
    hsa-miR-4324 hsa-miR-302f
    SwitchGear 3'UTR luciferase reporter plasmidCLEC4E 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC4E
      QuantiTect SYBR Green Assays in human, mouse, rat CLEC4E
      QuantiFast Probe-based Assays in human, mouse, rat CLEC4E

    Additional mRNA sequence: 

    AB024718.1 AK312671.1 AY358499.1 BC000715.2 

    3 DOTS entries:

    DT.70105230  DT.100664345  DT.121199914 

    Selected AceView cDNA sequences (see all 37):

    AW264297 CD369372 CD742945 BC000715 AW236598 CB528932 AW295528 BG164873 
    CN480864 BQ004812 AI968491 BF061905 CD364806 AI761169 CD368203 AB024718 
    BG231605 BE311916 BM561994 AY358499 AW467175 AI990505 BQ707573 NM_014358 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4E    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                                -     -     -                                 
    SP2:                                            -     -                           
    SP3:                                      -     -     -                           
    SP4:                                            -     -     -                     
    SP5:                                                                              


    ECgene alternative splicing isoforms for CLEC4E

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLEC4E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLEC4E Expression
    About this image


    CLEC4E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    CLEC4E Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.236516
        Pathway & Disease-focused RT2 Profiler PCR Array including CLEC4E: 
              Toll-Like Receptor Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC4E gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec4e1 , 5 C-type lectin domain family 4, member e1, 5 79.5(n)1
    67.14(a)1
      6 (58.35 cM)5
    566191  NM_019948.21  NP_064332.11 
     1232817895 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-154o6.61 si:ch211-154o6.6 53.08(n)
    43.85(a)
      564061  NM_001045039.2  NP_001038504.2 


    ENSEMBL Gene Tree for CLEC4E (if available)
    TreeFam Gene Tree for CLEC4E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLEC4E gene
    CD2072  CLEC17A2  ASGR22  CLEC4M2  CLEC4F2  CD2092  CLEC4A2  FCER22  
    CLEC10A2  CLEC6A2  ASGR12  CLEC4C2  CLEC4D2  CLEC4G2  
    16 SIMAP similar genes for CLEC4E using alignment to 4 protein entries:     CLC4E_HUMAN (see all proteins):
    CLEC4D    CLEC17A    CLEC4M    CD209    VCAN    CD207
    CLEC10A    CLEC2D    CLEC6A    FCER2    CLEC4C    ASGR2
    HBXBP    CLEC4A    OLR1    ASGR1

    Find genes that share paralogs with CLEC4E           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLEC4E (see all 263)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1123506651,2
    C,F--8685463(+) AAATTC/TTAAAT 1 -- ds50015Minor allele frequency- T:0.18WA CSA NA EA 362
    rs774382811,2
    C,F--8685557(+) AAACAC/GCAATG 1 -- ds50011Minor allele frequency- G:0.11WA 118
    rs1414621161,2
    C--8685558(+) AACACA/CAATGA 1 -- ds50010--------
    rs1930663911,2
    --8685573(+) AAAAAA/GAGTCT 1 -- ds50010--------
    rs1853078591,2
    --8685781(+) CTCATC/TCAGTG 1 -- ds50010--------
    rs1503669211,2
    C--8686022(+) TCACAA/GTAGCA 1 -- ut310--------
    rs1903053601,2
    --8686110(+) CTAAGA/CAGCCT 1 -- ut310--------
    rs1380396481,2
    --8686274(+) CAGACA/GCTGGA 1 -- ut310--------
    rs1811839131,2
    --8686330(+) AAACAA/GTATTA 1 -- ut310--------
    rs1839926961,2
    --8686388(+) CTCCAA/CGACAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLEC4E (8685901 - 8693559 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CLEC4E:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898737CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLEC4E
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609962    OMIM disorders: --

    1 disease for CLEC4E:    
    About MalaCards
    chromoblastomycosis

    1 disease from the University of Copenhagen DISEASES database for CLEC4E:
    Chromoblastomycosis

    Find genes that share disorders with CLEC4E           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: CLEC4E (1 document)

    Export disorders for CLEC4E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLEC4E gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with CLEC4E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages. (PubMed id 10528209)1, 2, 3 Matsumoto M.... Akira S. (J. Immunol. 1999)
    2. Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans. (PubMed id 18509109)1, 2, 9 Bugarcic A....Blanchard H. (Glycobiology 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL. (PubMed id 24101491)1 Furukawa A....Maenaka K. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    6. Macrophage-inducible C-type lectin is associated with anti-cyclic citrullinated peptide antibodies-positive rheumatoid arthritis in men. (PubMed id 22932191)1 Wu X.Y....Li Z.G. (Chin. Med. J. 2012)
    7. Mincle polarizes human monocyte and neutrophil responses to Candida albicans. (PubMed id 22641025)1 Vijayan D....Wells C.A. (Immunol. Cell Biol. 2012)
    8. Silencing of renal DNaseI in murine lupus nephritis imposes exposure of large chromatin fragments and activation of Toll like receptors and the Clec4e. (PubMed id 22479529)1 Thiyagarajan D....Mortensen E.S. (PLoS ONE 2012)
    9. Mincle and human B cell function. (PubMed id 22698596)1 Kawata K....Eric Gershwin M. (J. Autoimmun. 2012)
    10. Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans. (PubMed id 21282371)1 Ichioka M....Ogawa Y. (Diabetes 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26253 HGNC: 14555 AceView: CLECSF9 Ensembl:ENSG00000166523 euGenes: HUgn26253
    ECgene: CLEC4E Kegg: 26253 H-InvDB: CLEC4E

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLEC4E Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00134

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLEC4E gene:
    Search GeneIP for patents involving CLEC4E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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