Aliases for CLEC4E Gene
External Ids for CLEC4E Gene
Previous HGNC Symbols for CLEC4E Gene
Previous GeneCards Identifiers for CLEC4E Gene
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLEC4E Gene
CLEC4E (C-Type Lectin Domain Family 4 Member E) is a Protein Coding gene. Diseases associated with CLEC4E include Common Wart. Among its related pathways are Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is CLEC4C.
UniProtKB/Swiss-Prot for CLEC4E Gene
C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.