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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC4E Gene

protein-coding   GIFtS: 50
GCID: GC12M008685

C-type lectin domain family 4, member E

(Previous names: C-type (calcium dependent, carbohydrate-recognition domain)...)
(Previous symbol: CLECSF9)
 Explore 8 diseases affiliated with
CLEC4E via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLEC4E    

Aliases
for CLEC4E gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
C-Type Lectin Domain Family 4, Member E1 2     Macrophage-Inducible C-Type Lectin2 3
CLECSF91 2 3     C-Type Lectin Superfamily Member 92 3
MINCLE2 3 5     Mincle1
C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily
Member 91 2
     C-Type Lectin Domain Family 4 Member E2

External Ids:    HGNC: 145551   Entrez Gene: 262532   Ensembl: ENSG000001665237   OMIM: 6099625   UniProtKB: Q9ULY53   

Export aliases for CLEC4E gene to outside databases

Previous GC identifers: GC12M008578 GC12M008468


Summaries
for CLEC4E gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLEC4E:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this
family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling,
glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a
downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation.
Alternative splice variants have been described but their full-length sequence has not been determined. This gene is
closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLC4E_HUMAN, Q9ULY5
Function: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells,
fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection
of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose
residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by
dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G.
Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B




Genomic Views
for CLEC4E gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC4E gene promoter:
         AREB6   MEF-2A   PPAR-gamma1   SRY   POU2F1   POU2F1a   Cart-1   aMEF-2   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLEC4E promoter sequence
   Search SABiosciences Chromatin IP Primers for CLEC4E

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC4E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

CLEC4E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC4E gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M008685:  view genomic region     (about GC identifiers)

Start:
 8,685,901 bp from pter      End:
 8,693,559 bp from pter
Size:
 7,659 bases      Orientation:
 minus strand

Proteins
for CLEC4E gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLC4E_HUMAN, Q9ULY5 (See protein sequence)
Recommended Name: C-type lectin domain family 4 member E  
Size: 219 amino acids; 25073 Da
Subunit: Monomer. Homodimer
Subcellular location: Membrane; Single-pass type II membrane protein (Probable)
Secondary accessions: B2R6Q6

Explore the universe of human proteins at neXtProt for CLEC4E: NX_Q9ULY5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULY5

    • CLEC4E Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055173.1  
    ENSEMBL proteins: 
     ENSP00000299663   ENSP00000387737   ENSP00000443034   ENSP00000443328   ENSP00000404994  

    Human Recombinant Protein Products: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CLEC4E
    OriGene Protein Over-expression Lysate: CLEC4E
    OriGene Custom Protein Services for CLEC4E 
    GenScript Custom Purified and Recombinant Proteins Services for CLEC4E
    Novus Biologicals CLEC4E Protein
    Novus Biologicals CLEC4E Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLEC4E

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    CLEC4E for ontologies           About GeneDecksing



    CLEC4E Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    GenScript Custom Superior Antibodies Services for CLEC4E
    Novus Biologicals CLEC4E Antibodies
    Search for Antibodies for CLEC4E at Abcam  
    Uscn Antibodies for CLEC4E
    Search ThermoFisher Antibodies for CLEC4E

    Assay Products for CLEC4E: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CLEC4E

    Protein Domains /
    Families
    for CLEC4E gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLEC4E for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q9ULY5

    ProtoNet protein and cluster: Q9ULY5

    1 Blocks protein family: IPB002353 Type II antifreeze protein signature

    UniProtKB/Swiss-Prot: CLC4E_HUMAN, Q9ULY5
    Similarity: Contains 1 C-type lectin domain


    Function
    for CLEC4E gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLC4E_HUMAN, Q9ULY5
    Function: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells,
    fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection
    of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose
    residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by
    dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G.
    Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CLEC4E
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC4E
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CLEC4E:
    hsa-miR-4324 hsa-miR-302f
    SwitchGear 3'UTR luciferase reporter plasmid: CLEC4E 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC4E (see all 7)
    OriGene shRNA RFP: CLEC4E
    OriGene siRNA: CLEC4E
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC4E

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CLEC4E

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4E (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4E
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CLEC4E (NM_014358)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC4E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4E 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CLEC4E
    Search LifeMap BioReagents cell lines for CLEC4E

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4E

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding IEA--


    CLEC4E for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for CLEC4E: Clec4etm1.1Cfg Clec4etm1Tks Clec4etm1Lex
         4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Clec4e):
     cardiovascular system  hematopoietic system  immune system  no phenotypic analysis 

    CLEC4E for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLEC4E gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Tuberculosis
    		Tuberculosis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for CLEC4E):
        Tuberculosis


    CLEC4E for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC4E

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CLEC4E (ENSP000002996634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCER1GENSP000002899024STRING: ENSP00000289902
    SYKENSP000003648984STRING: ENSP00000364898
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0050715positive regulation of cytokine secretion IEA--


    CLEC4E for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLEC4E gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLEC4E
    Search CenterWatch for drugs/clinical trials and news about CLEC4E / CLC4E 

    Transcripts
    for CLEC4E gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLEC4E gene: 
    NM_014358.2  

    Unigene Cluster for CLEC4E:

    C-type lectin domain family 4, member E
    Hs.236516  [show with all ESTs]
    Unigene Representative Sequence: NM_014358
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299663(uc001quo.1) ENST00000446457 ENST00000545274 ENST00000537698
    ENST00000450725 ENST00000446809

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CLEC4E
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC4E
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CLEC4E:
    hsa-miR-4324 hsa-miR-302f
    SwitchGear 3'UTR luciferase reporter plasmid: CLEC4E 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC4E (see all 7)
    OriGene shRNA RFP: CLEC4E
    OriGene siRNA: CLEC4E
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC4E
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4E (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4E
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CLEC4E (NM_014358)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC4E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4E 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC4E
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC4E
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC4E
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC4E

    Additional cDNA sequence: 

    AB024718.1 AK312671.1 AY358499.1 BC000715.2 

    3 DOTS entries:

    DT.70105230  DT.100664345  DT.121199914 

    24/37 AceView cDNA sequences (see all 37):

    BC000715 AW236598 BF061905 CD742945 CB528932 AW264297 CN480864 AI968491 
    CD369372 AW295528 BG164873 BQ004812 CD368203 AB024718 CD364806 NM_014358 
    AY358499 AW467175 BM561994 AI990505 BQ707573 AI761169 BE311916 BG231605 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4E    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                                -     -     -                                 
    SP2:                                            -     -                           
    SP3:                                      -     -     -                           
    SP4:                                            -     -     -                     
    SP5:                                                                              


    ECgene alternative splicing isoforms for CLEC4E

    Expression
    for CLEC4E gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLEC4E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLEC4E expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartMyocardiumCardiac FibroblastsEpicardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CLEC4E Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLEC4E

    SOURCE GeneReport for Unigene cluster: Hs.236516
        SABiosciences Expression via Pathway-Focused PCR Array including CLEC4E: 
              Toll-Like Receptor Signaling Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC4E
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4E

    Orthologs
    for CLEC4E gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC4E gene from 1/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii BX682234.36
    si:ch73-343l4.56
    (see all 41)    		 si:ch73-343l4.5
    (see all 41)    		 8(a)
    40(a)
    (see all 41)    		 many ↔ many
    many ↔ many
    (see all 41)    		 10(7530024-7534761)
    1(56420677-56430629)


    ENSEMBL Gene Tree for CLEC4E (if available)
    TreeFam Gene Tree for CLEC4E (if available) 

    Paralogs
    for CLEC4E gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLEC4E gene
    CD2072  ASGR22  CLEC4M2  CLEC4F2  CD2092  CLEC10A2  FCER22  CLEC4A2  
    CLEC6A2  ASGR12  CLEC4C2  CLEC4D2  CLEC4G2  
    16 SIMAP similar genes for CLEC4E using alignment to 4 protein entries:     CLC4E_HUMAN (see all proteins):
    CLEC4D    CLEC17A    CLEC4M    CD209    VCAN    CD207
    CLEC10A    CLEC2D    CLEC6A    FCER2    CLEC4C    ASGR2
    HBXBP    CLEC4A    OLR1    ASGR1

    CLEC4E for paralogs           About GeneDecksing



    Genomic Variants
    for CLEC4E gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/185 NCBI SNPs in CLEC4E are shown (see all 185)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1123506651,2
    		C,F,--8685463(+) AAATTC/TTAAAT 1 -- ds50015Minor allele frequency- T:0.18WA CSA NA EA 362
    rs774382811,2
    		F,--8685557(+) AAACAC/GCAATG 1 -- ds50011Minor allele frequency- G:0.11WA 118
    rs1414621161,2
    		--8685558(+) AACACA/CAATGA 1 -- ds50010--------
    rs1930663911,2
    		--8685573(+) AAAAAA/GAGTCT 1 -- ds50010--------
    rs1853078591,2
    		--8685781(+) CTCATC/TCAGTG 1 -- ds50010--------
    rs1503669211,2
    		--8686022(+) TCACAA/GTAGCA 1 -- ut310--------
    rs1903053601,2
    		--8686110(+) CTAAGA/CAGCCT 1 -- ut310--------
    rs1380396481,2
    		--8686274(+) CAGACA/GCTGGA 1 -- ut310--------
    rs1811839131,2
    		--8686330(+) AAACAA/GTATTA 1 -- ut310--------
    rs1839926961,2
    		--8686388(+) CTCCAA/CGACAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLEC4E (8685901 - 8693559 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLEC4E: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC4E
    DNA2.0 Custom Variant and Variant Library Synthesis for CLEC4E

    Disorders / Diseases
    for CLEC4E gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLEC4E for disorders           About GeneDecksing

    OMIM gene information: 609962    OMIM disorders: --

    8 diseases for CLEC4E:    About MalaCards
    chromoblastomycosis    eczema    rheumatoid arthritis    hepatitis b
    arthritis    hepatitis    obesity    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for CLEC4E:
    Chromoblastomycosis
    Human Genome Epidemiology (HuGE) Navigator: CLEC4E (1 document)

    Export disorders for CLEC4E gene to outside databases

    Publications
    for CLEC4E gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLEC4E gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with CLEC4E)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages. (PubMed id 10528209)1, 2, 3 Matsumoto M.... Akira S. (1999)
    2. Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans. (PubMed id 18509109)1, 2, 9 Bugarcic A....Blanchard H. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Silencing of renal DNaseI in murine lupus nephritis im poses exposure of large chromatin fragments and activation of Toll like receptor s and the Clec4e. (PubMed id 22479529)1 Thiyagarajan D....Mortensen E.S. (2012)
    6. Increased expression of macrophage-inducible C-type l ectin in adipose tissue of obese mice and humans. (PubMed id 21282371)1 Ichioka M....Ogawa Y. (2011)
    7. Mast cells generated from patients with atopic eczema have enhanced levels of granule mediators and an impaired Dectin-1 expression. (PubMed id 20608913)1 Ribbing C....Scheynius A. (2011)
    8. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    9. Crosstalk between components of the innate immune sys tem: promoting anti-microbial defenses and avoiding immunopathologies. (PubMed id 19120481)1 Crozat K....Dalod M. (2009)
    10. Mincle is an ITAM-coupled activating receptor that se nses damaged cells. (PubMed id 18776906)2 Yamasaki S....Saito T. (2008)

    External Searches for CLEC4E gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing CLEC4E gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26253 HGNC: 14555 AceView: CLECSF9 Ensembl:ENSG00000166523 euGenes: HUgn26253
    ECgene: CLEC4E Kegg: 26253 H-InvDB: CLEC4E

    Other Databases showing CLEC4E gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLEC4E gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLEC4E Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00134

    Intellectual Property
    for CLEC4E gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLEC4E gene:
    Search GeneIP for patents involving CLEC4E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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