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Aliases for CLEC4D Gene

Aliases for CLEC4D Gene

  • C-Type Lectin Domain Family 4 Member D 2 3 5
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 8 2 3
  • C-Type Lectin Domain Family 4, Member D 2 3
  • C-Type Lectin Superfamily Member 8 3 4
  • C-Type Lectin-Like Receptor 6 3 4
  • CLECSF8 3 4
  • CLEC-6 3 4
  • MCL 3 4
  • Macrophage C-Type Lectin 3
  • C-Type Lectin Receptor 3
  • CD368 3
  • CLEC6 3
  • MPCL 3

External Ids for CLEC4D Gene

Previous HGNC Symbols for CLEC4D Gene


Previous GeneCards Identifiers for CLEC4D Gene

  • GC12P008559
  • GC12P008666
  • GC12P008448

Summaries for CLEC4D Gene

Entrez Gene Summary for CLEC4D Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLEC4D Gene

CLEC4D (C-Type Lectin Domain Family 4 Member D) is a Protein Coding gene. Among its related pathways are Immune System and CLEC7A (Dectin-1) signaling. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC6A.

UniProtKB/Swiss-Prot for CLEC4D Gene

  • Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC4D Gene

Genomics for CLEC4D Gene

Regulatory Elements for CLEC4D Gene

Enhancers for CLEC4D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLEC4D on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC4D Gene

8,509,475 bp from pter
8,522,366 bp from pter
12,892 bases
Plus strand

Genomic View for CLEC4D Gene

Genes around CLEC4D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC4D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC4D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC4D Gene

Proteins for CLEC4D Gene

  • Protein details for CLEC4D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 4 member D
    Protein Accession:
    Secondary Accessions:
    • Q8N5J5

    Protein attributes for CLEC4D Gene

    215 amino acids
    Molecular mass:
    24704 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CLEC4D Gene

neXtProt entry for CLEC4D Gene

Proteomics data for CLEC4D Gene at MOPED

Post-translational modifications for CLEC4D Gene

  • Glycosylation at Asn 45, Asn 102, and Asn 111
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC4D Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CLEC4D (CLEC4D/CLECSF8)

No data available for DME Specific Peptides for CLEC4D Gene

Domains & Families for CLEC4D Gene

Gene Families for CLEC4D Gene

Protein Domains for CLEC4D Gene

Suggested Antigen Peptide Sequences for CLEC4D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC4D: view

Function for CLEC4D Gene

Molecular function for CLEC4D Gene

UniProtKB/Swiss-Prot Function:
Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells.
UniProtKB/Swiss-Prot Induction:
By autocrine inflammatory stimuli.
genes like me logo Genes that share phenotypes with CLEC4D: view

Animal Models for CLEC4D Gene

MGI Knock Outs for CLEC4D:

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC4D

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLEC4D Gene

Localization for CLEC4D Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC4D Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for CLEC4D Gene COMPARTMENTS Subcellular localization image for CLEC4D gene
Compartment Confidence
plasma membrane 5
extracellular 3

No data available for Gene Ontology (GO) - Cellular Components for CLEC4D Gene

Pathways & Interactions for CLEC4D Gene

genes like me logo Genes that share pathways with CLEC4D: view

Pathways by source for CLEC4D Gene

Interacting Proteins for CLEC4D Gene

Gene Ontology (GO) - Biological Process for CLEC4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0038094 Fc-gamma receptor signaling pathway IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with CLEC4D: view

No data available for SIGNOR curated interactions for CLEC4D Gene

Drugs & Compounds for CLEC4D Gene

(1) Drugs for CLEC4D Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CLEC4D Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLEC4D: view

Transcripts for CLEC4D Gene

mRNA/cDNA for CLEC4D Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC4D Gene

C-type lectin domain family 4, member D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4D Gene

No ASD Table

Relevant External Links for CLEC4D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC4D Gene

mRNA expression in normal human tissues for CLEC4D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC4D Gene

This gene is overexpressed in Whole Blood (x45.9).

Protein differential expression in normal tissues from HIPED for CLEC4D Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC4D Gene

SOURCE GeneReport for Unigene cluster for CLEC4D Gene Hs.351811

mRNA Expression by UniProt/SwissProt for CLEC4D Gene

Tissue specificity: Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma.
genes like me logo Genes that share expression patterns with CLEC4D: view

Protein tissue co-expression partners for CLEC4D Gene

- Elite partner

Primer Products

Orthologs for CLEC4D Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLEC4D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLEC4D 35
  • 79.25 (n)
  • 66.98 (a)
  • 67 (a)
(Canis familiaris)
Mammalia CLEC4D 35
  • 80.38 (n)
  • 69.38 (a)
  • 69 (a)
(Mus musculus)
Mammalia Clec4d 35
  • 74.61 (n)
  • 61.68 (a)
Clec4d 16
Clec4d 36
  • 61 (a)
(Pan troglodytes)
Mammalia CLEC4D 35
  • 99.38 (n)
  • 98.14 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Clec4d 35
  • 73.87 (n)
  • 59.15 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
Species with no ortholog for CLEC4D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC4D Gene

Gene Tree for CLEC4D (if available)
Gene Tree for CLEC4D (if available)

Paralogs for CLEC4D Gene

(13) SIMAP similar genes for CLEC4D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLEC4D: view

Variants for CLEC4D Gene

Sequence variations from dbSNP and Humsavar for CLEC4D Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4304840 - 8,515,301(+) TTCTC(A/G)GTGTC reference, missense
rs7135960 -- 8,511,755(+) AGCAC(G/T)ACAAA upstream-variant-2KB
rs7138828 -- 8,521,393(+) GTCAT(A/G)ATGGT downstream-variant-500B, utr-variant-3-prime
rs7298114 -- 8,518,778(+) CTAAG(A/G)CAATA intron-variant
rs7298236 -- 8,518,844(+) ATTTA(A/G)GAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC4D Gene

Variant ID Type Subtype PubMed ID
nsv518772 CNV Gain 19592680
nsv518125 CNV Loss 19592680
nsv526021 CNV Loss 19592680
nsv898737 CNV Loss 21882294

Variation tolerance for CLEC4D Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.54; 72.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CLEC4D Gene

Disorders for CLEC4D Gene

Relevant External Links for CLEC4D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLEC4D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC4D Gene

Publications for CLEC4D Gene

  1. The human C-type lectin CLECSF8 is a novel monocyte/macrophage endocytic receptor. (PMID: 14971047) Arce I. … Fernandez-Ruiz E. (Eur. J. Immunol. 2004) 3 4 23 67
  2. Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL. (PMID: 24101491) Furukawa A. … Maenaka K. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  3. The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase. (PMID: 22689578) Graham L.M. … Brown G.D. (J. Biol. Chem. 2012) 3
  4. Profiles of carbohydrate ligands associated with adsorbed proteins on self-assembled monolayers of defined chemistries. (PMID: 19353560) Shankar S.P. … Babensee J.E. (J Biomed Mater Res A 2010) 23
  5. Glycan gimmickry by parasitic helminths: a strategy for modulating the host immune response? (PMID: 19748975) van Die I. … Cummings R.D. (Glycobiology 2010) 23

Products for CLEC4D Gene

Sources for CLEC4D Gene