Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CLEC4D Gene

protein-coding   GIFtS: 49
GCID: GC12P008666

C-Type Lectin Domain Family 4, Member D

(Previous names: C-type (calcium dependent, carbohydrate-recognition domain)...)
(Previous symbol: CLECSF8)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
C-Type Lectin Domain Family 4, Member D1 2     C-Type Lectin-Like Receptor 62 3
CLECSF81 2 3 5     CLEC62 5
C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin,
Superfamily Member 81 2
     MPCL2
CLEC-62 3     C-Type Lectin Domain Family 4 Member D2
MCL2 3     C-Type Lectin Receptor2
C-Type Lectin Superfamily Member 82 3     Macrophage C-Type Lectin2

External Ids:    HGNC: 145541   Entrez Gene: 3383392   Ensembl: ENSG000001665277   OMIM: 6099645   UniProtKB: Q8WXI83   

Export aliases for CLEC4D gene to outside databases

Previous GC identifers: GC12P008559 GC12P008448


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CLEC4D Gene:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this
family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling,
glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other
CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CLEC4D Gene:
CLEC4D (C-type lectin domain family 4, member D) is a protein-coding gene. Diseases associated with CLEC4D include acne, and behcet's disease. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD207.

UniProtKB/Swiss-Prot: CLC4D_HUMAN, Q8WXI8
Function: Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either
for clearance of the antigen, or for processing and further presentation to T cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLEC4D gene promoter:
         STAT5B   GR   Nkx3-1 v4   FOXF2   GR-beta   C/EBPalpha   HEN1   FAC1   Nkx3-1 v3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC4D promoter sequence
   Search Chromatin IP Primers for CLEC4D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC4D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

CLEC4D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC4D gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P008666:  view genomic region     (about GC identifiers)

Start:
8,662,071 bp from pter      End:
8,674,962 bp from pter
Size:
12,892 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CLC4D_HUMAN, Q8WXI8 (See protein sequence)
Recommended Name: C-type lectin domain family 4 member D  
Size: 215 amino acids; 24704 Da
2 PDB 3D structures from and Proteopedia for CLEC4D:
2LS8 (3D)        3WHD (3D)    
Secondary accessions: Q8N5J5

Explore the universe of human proteins at neXtProt for CLEC4D: NX_Q8WXI8

Explore proteomics data for CLEC4D at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn45, Asn102, Asn111
  • Modification sites at PhosphoSitePlus

  • See CLEC4D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_525126.2  
    ENSEMBL proteins: 
     ENSP00000371496   ENSP00000299665  

    CLEC4D Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CLEC4D
    OriGene Protein Over-expression Lysate for CLEC4D
    OriGene MassSpec for CLEC4D
    OriGene Custom Protein Services for CLEC4D
    GenScript Custom Purified and Recombinant Proteins Services for CLEC4D
    Novus Biologicals CLEC4D Protein
    Novus Biologicals CLEC4D Lysates
    Sino Biological Recombinant Protein for CLEC4D
    Sino Biological Cell Lysate for CLEC4D
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLEC4D

    CLEC4D Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CLEC4D (CLEC4D/CLECSF8)
    OriGene Antibodies for CLEC4D
    OriGene Custom Antibody Services for CLEC4D
    Novus Biologicals CLEC4D Antibodies
    Search for Antibodies for CLEC4D at Abcam
    Cloud-Clone Corp. Antibodies for CLEC4D
    Search ThermoFisher Antibodies for CLEC4D
    LSBio Antibodies in human, mouse, rat for CLEC4D

    CLEC4D Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CLEC4D
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLEC4D
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLEC4D
    Cloud-Clone Corp. CLIAs for CLEC4D


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q8WXI8

    ProtoNet protein and cluster: Q8WXI8

    1 Blocks protein domain: IPB002353 Type II antifreeze protein signature

    UniProtKB/Swiss-Prot: CLC4D_HUMAN, Q8WXI8
    Similarity: Contains 1 C-type lectin domain


    CLEC4D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLC4D_HUMAN, Q8WXI8
    Function: Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either
    for clearance of the antigen, or for processing and further presentation to T cells
    Induction: By autocrine inflammatory stimuli

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding IEA--
         
    CLEC4D for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Clec4d):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  no phenotypic analysis 
     respiratory system 

    CLEC4D for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CLEC4D: Clec4dtm1.1Cfg Clec4dtm1.1Shoy

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLEC4D
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLEC4D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC4D
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLEC4D

    miRNA
    Products:
        
    miRTarBase miRNAs that target CLEC4D:
    hsa-mir-30a-5p (MIRT049934), hsa-mir-142-3p (MIRT021599)

    Block miRNA regulation of human, mouse, rat CLEC4D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLEC4D (see all 15):
    hsa-miR-21* hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548i hsa-miR-548h hsa-miR-449c* hsa-miR-548c-5p
    SwitchGear 3'UTR luciferase reporter plasmidCLEC4D 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLEC4D
    Predesigned siRNA for gene silencing in human, mouse, rat CLEC4D

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLEC4D

    Clone
    Products:
         
    OriGene clones in human, mouse for CLEC4D (see all 8)
    OriGene ORF clones in mouse, rat for CLEC4D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLEC4D (NM_080387)
    Sino Biological Human cDNA Clone for CLEC4D
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC4D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4D

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CLEC4D
    Browse ESI BIO Cell Lines and PureStem Progenitors for CLEC4D 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CLC4D_HUMAN, Q8WXI8: Membrane; Single-pass type II membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    CLEC4D for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLEC4D
    Interactions:

        Search GeneGlobe Interaction Network for CLEC4D

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045087innate immune response IEA--

    CLEC4D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLEC4D (CLC4D)

    4 Novoseek inferred chemical compound relationships for CLEC4D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 76.8 8 12960229 (1), 17467811 (1), 18160296 (1), 18811944 (1) (see all 8)
    polysaccharide 45.1 7 18679407 (1), 19764413 (1), 19748975 (1), 18981244 (1) (see all 5)
    carbohydrates 35.7 1 19353560 (1)
    tyrosine 0.059 4 18631453 (1), 20193029 (1), 19422460 (1)



    CLEC4D for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CLEC4D gene: 
    NM_080387.4  

    Unigene Cluster for CLEC4D:

    C-type lectin domain family 4, member D
    Hs.351811  [show with all ESTs]
    Unigene Representative Sequence: NM_080387
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382064 ENST00000299665(uc001qun.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLEC4D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLEC4D (see all 15):
    hsa-miR-21* hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-548i hsa-miR-548h hsa-miR-449c* hsa-miR-548c-5p
    SwitchGear 3'UTR luciferase reporter plasmidCLEC4D 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CLEC4D
    Predesigned siRNA for gene silencing in human, mouse, rat CLEC4D
    Clone
    Products:
         
    OriGene clones in human, mouse for CLEC4D (see all 8)
    OriGene ORF clones in mouse, rat for CLEC4D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLEC4D (NM_080387)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC4D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4D
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CLEC4D
    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC4D
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC4D
      QuantiTect SYBR Green Assays in human, mouse, rat CLEC4D
      QuantiFast Probe-based Assays in human, mouse, rat CLEC4D

    Additional mRNA sequence: 

    AF411850.1 AK314071.1 AY115592.1 AY297446.1 AY486482.1 AY486483.1 BC032313.1 

    1 DOTS entry:

    DT.75164002 

    12 AceView cDNA sequences:

    NM_080387 BC032313 AY115592 CA412024 AY297446 BI909298 AF411850 BI910606 
    AW074559 BM561886 AJ712390 BF902179 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CLEC4D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACATTAAT
    CLEC4D Expression
    About this image


    CLEC4D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Hippocampus
    CLEC4D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLEC4D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.351811

    UniProtKB/Swiss-Prot: CLC4D_HUMAN, Q8WXI8
    Tissue specificity: Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is
    confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma

        Custom PCR Arrays for CLEC4D
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CLEC4D
    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC4D
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC4D
    QuantiTect SYBR Green Assays in human, mouse, rat CLEC4D
    QuantiFast Probe-based Assays in human, mouse, rat CLEC4D
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CLEC4D gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec4d1 , 5 C-type lectin domain family 4, member d1, 5 74.61(n)1
    61.68(a)1
      6 (58.33 cM)5
    174741  NM_010819.41  NP_034949.31 
     1232621075 


    ENSEMBL Gene Tree for CLEC4D (if available)
    TreeFam Gene Tree for CLEC4D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CLEC4D gene
    CD2072  CLEC17A2  CLEC4E2  ASGR22  CLEC4M2  CLEC4F2  CD2092  CLEC4A2  
    FCER22  CLEC10A2  CLEC6A2  ASGR12  CLEC4C2  CLEC4G2  
    13 SIMAP similar genes for CLEC4D using alignment to 2 protein entries:     CLC4D_HUMAN (see all proteins):
    CLEC6A    CLEC4A    CLEC4E    CLEC4C    DKFZp761L191    CD209
    CLEC4M    ACAN    ASGR2    FCER2    HBXBP    VCAN
    DKFZp686K06110

    CLEC4D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CLEC4D (see all 286)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1149613601,2
    C,F--8664161(+) CTGCCT/GCCTAC 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1931600721,2
    --8664257(+) TGAGAC/GTGGCC 1 -- us2k10--------
    rs1476814001,2
    --8664270(+) AGATAC/TAGGAA 1 -- us2k10--------
    rs1828080891,2
    --8664313(+) GGGGGA/CAAAGA 1 -- us2k10--------
    rs71359601,2
    C,F,A,H--8664351(+) AGCACG/TACAAA 1 -- us2k123Minor allele frequency- T:0.33NS EA NA WA CSA 2348
    rs1161815061,2
    C,F--8664515(+) AATCCT/CGGAGG 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1424327561,2
    --8664563(+) CTCTGC/GGAAGG 1 -- us2k10--------
    rs284855671,2
    C,F--8664719(+) TGGGCT/CACAGG 1 -- us2k18Minor allele frequency- C:0.34WA NA CSA EA 367
    rs1130898801,2
    F--8664739(+) CAGCAG/TCCTAC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1478730921,2
    C--8664740(+) AGCATC/TCTACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLEC4D (8662071 - 8674962 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CLEC4D:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518125CNV Loss19592680
    nsv526021CNV Loss19592680
    nsv898737CNV Loss21882294
    nsv518772CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLEC4D
    DNA2.0 Custom Variant and Variant Library Synthesis for CLEC4D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609964    OMIM disorders: --

    8 diseases for CLEC4D:    
    About MalaCards
    acne    behcet's disease    influenza    hiv-1
    systemic lupus erythematosus    lupus erythematosus    asthma    tonsillitis


    CLEC4D for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for CLEC4D gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 24.1 2 12960236 (1), 18593570 (1)
    hiv infections 18.5 2 19363450 (1), 20395432 (1)
    tumors 0 1 15024991 (1)
    cancer 0 1 11774590 (1)


    Export disorders for CLEC4D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CLEC4D gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with CLEC4D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human C-type lectin CLECSF8 is a novel monocyte/macrophage endocytic receptor. (PubMed id 14971047)1, 2, 9 Arce I.... Fernandez-Ruiz E. (Eur. J. Immunol. 2004)
    2. Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. (PubMed id 15368084)1, 2 Flornes L.M....Fossum S. (Immunogenetics 2004)
    3. Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL. (PubMed id 24101491)1 Furukawa A....Maenaka K. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    4. The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase. (PubMed id 22689578)1 Graham L.M....Brown G.D. (J. Biol. Chem. 2012)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. (PubMed id 12945048)1 Ebner S....Ben-Tal N. (Proteins 2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. C-type lectin-like domains. (PubMed id 10508765)1 Drickamer K. (Curr. Opin. Struct. Biol. 1999)
    10. Abundant expression of HIV target cells and C-type lectin receptors in the foreskin tissue of young Kenyan men. (PubMed id 20395432)9 Hirbod T....Broliden K. (Am. J. Pathol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 338339 HGNC: 14554 AceView: CLECSF8 Ensembl:ENSG00000166527 euGenes: HUgn338339
    ECgene: CLEC4D H-InvDB: CLEC4D

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CLEC4D Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_365

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CLEC4D gene:
    Search GeneIP for patents involving CLEC4D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CLEC4D (CLEC4D/CLECSF8)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CLEC4D   OriGene RNAi products in human, mouse, rat for CLEC4D  
     OriGene qPCR primer pairs and template standards for CLEC4D   OriGene Protein Over-expression Lysate for CLEC4D  
     OriGene MassSpec something-or-other for CLEC4D   OriGene clones in human, mouse for CLEC4D  
     OriGene qSTAR qPCR primer pairs in human, mouse for CLEC4D   OriGene Purified Protein for CLEC4D  
     OriGene ORF clones in mouse, rat for CLEC4D   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLEC4D   OriGene Custom Protein Services for CLEC4D  

     
     
     Block miRNA regulation of human, mouse, rat CLEC4D using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CLEC4D
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC4D Predesigned siRNA for gene silencing in human, mouse, rat CLEC4D
     QuantiFast Probe-based Assays in human, mouse, rat CLEC4D QuantiTect SYBR Green Assays in human, mouse, rat CLEC4D
     Custom PCR Arrays for CLEC4D Search Chromatin IP Primers for CLEC4D
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC4D  Search GeneGlobe Interaction Network for CLEC4D
     Regulatory tfbs in CLEC4D promoter
     GenScript Custom Purified and Recombinant Proteins Services for CLEC4D GenScript cDNA clones with any tag delivered in your preferred vector for CLEC4D
     GenScript Custom Assay Services for CLEC4D GenScript Custom overexpressing Cell Line Services for CLEC4D
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CLEC4D (CLC4D)
     Proteins for CLEC4D
     Cell Lysates for CLEC4D
     cDNA Clones for CLEC4D
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CLEC4D antibodies
     CLEC4D proteins
     CLEC4D lysates
     Search for Antibodies for CLEC4D at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CLEC4D
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CLEC4D
     Antibodies for CLEC4D
     ELISAs for CLEC4D
     CLIAs for CLEC4D



     Browse ESI BIO Cell Lines and PureStem Progenitors for CLEC4D
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4D
     SwitchGear 3'UTR luciferase reporter plasmids for CLEC4D
     SwitchGear Promoter luciferase reporter plasmids for CLEC4D
     Search ThermoFisher Antibodies for CLEC4D
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4D
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLEC4D
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLEC4D
     LSBio Antibodies in human, mouse, rat for CLEC4D
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CLEC4D gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4