Aliases for CLEC4C Gene
External Ids for CLEC4C Gene
Previous HGNC Symbols for CLEC4C Gene
Previous GeneCards Identifiers for CLEC4C Gene
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLEC4C Gene
CLEC4C (C-Type Lectin Domain Family 4 Member C) is a Protein Coding gene. Diseases associated with CLEC4C include Blastic Plasmacytoid Dendritic Cell and Ovary Serous Adenocarcinoma. Among its related pathways are CLEC7A (Dectin-1) signaling and Dendritic Cells Developmental Lineage Pathway. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC6A.
UniProtKB/Swiss-Prot for CLEC4C Gene
Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.