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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC4C Gene

protein-coding   GIFtS: 50
GCID: GC12M007882

C-Type Lectin Domain Family 4, Member C

(Previous names: C-type (calcium dependent, carbohydrate-recognition domain)...)
(Previous symbols: CLECSF11, CLECSF7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 4, Member C1 2     C-Type Lectin Superfamily Member 72 3
CLECSF111 2 3 5     CD3032
CLECSF71 2 3     PRO341502
BDCA22 3 5     Blood Dendritic Cell Antigen 2 Protein2
DLEC2 3 5     C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin,
Superfamily Member 112
C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin,
Superfamily Member 71 2
     C-Type Lectin Domain Family 4 Member C2
Dendritic Lectin2 3     Dendritic Cell Lectin B2
BDCA-22 3     Blood Dendritic Cell Antigen 23
HECL2 3     CD303 Antigen3

External Ids:    HGNC: 132581   Entrez Gene: 1704822   Ensembl: ENSG000001981787   OMIM: 6066775   UniProtKB: Q8WTT03   

Export aliases for CLEC4C gene to outside databases

Previous GC identifers: GC12M007776 GC12M007695


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLEC4C Gene:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this
family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling,
glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein
may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been
identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLEC4C Gene: 
CLEC4C (C-type lectin domain family 4, member C) is a protein-coding gene. Diseases associated with CLEC4C include enamel caries, and dengue hemorrhagic fever, and among its related super-pathways are Inflammasome Activation Pathways. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD207.

UniProtKB/Swiss-Prot: CLC4C_HUMAN, Q8WTT0
Function: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments
for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in
plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and
mobilizes intracellular calcium. Does not seem to bind mannose




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC4C gene promoter:
         AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLEC4C promoter sequence
   Search SABiosciences Chromatin IP Primers for CLEC4C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC4C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2-p12.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.2-p12.3

CLEC4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC4C gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M007882:  view genomic region     (about GC identifiers)

Start:
7,882,011 bp from pter      End:
7,904,201 bp from pter
Size:
22,191 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLC4C_HUMAN, Q8WTT0 (See protein sequence)
Recommended Name: C-type lectin domain family 4 member C  
Size: 213 amino acids; 25038 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Probable)
Secondary accessions: D3DUU3 Q3T1C3 Q6UXS8 Q8WXX8
Alternative splicing: 2 isoforms:  Q8WTT0-1   Q8WTT0-2   

Explore the universe of human proteins at neXtProt for CLEC4C: NX_Q8WTT0

Explore proteomics data for CLEC4C at MOPED 

CLEC4C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CLEC4C Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_569708.1  NP_987099.1  

ENSEMBL proteins: 
 ENSP00000440428   ENSP00000346648   ENSP00000353500   ENSP00000438649   ENSP00000442457  
 ENSP00000445338  

Human Recombinant Protein Products for CLEC4C: 
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Cloud-Clone Corp. Proteins for CLEC4C 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

CLEC4C for ontologies           About GeneDecksing



CLEC4C Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of CLEC4C
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Cloud-Clone Corp. ELISAs for CLEC4C 
Cloud-Clone Corp. CLIAs for CLEC4C


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CD: CD molecules
CLEC: C-type lectin domain containing

4 InterPro protein domains:
 IPR016187 C-type_lectin_fold
 IPR018378 C-type_lectin_CS
 IPR016186 C-type_lectin-like
 IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry Q8WTT0

ProtoNet protein and cluster: Q8WTT0

1 Blocks protein domain: IPB002353 Type II antifreeze protein signature

UniProtKB/Swiss-Prot: CLC4C_HUMAN, Q8WTT0
Similarity: Contains 1 C-type lectin domain


CLEC4C for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CLC4C_HUMAN, Q8WTT0
Function: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments
for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in
plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and
mobilizes intracellular calcium. Does not seem to bind mannose

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030246carbohydrate binding IEA--
     
CLEC4C for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for CLEC4C:
 Decreased cilium length after  

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CLEC4C 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLEC4C

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC4C 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLEC4C 

miRNA
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Inhib. RNA
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Gene Editing
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Clone
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GenScript: all cDNA clones in your preferred vector (see all 2): CLEC4C (NM_203503)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC4C
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4C
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4C


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CLEC4C About                                                                                                See pathways by source

SuperPathContained pathways About
1Toll-Like receptor Signaling Pathways
Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for CLEC4C
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC4C

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for CLEC4C (Q8WTT03 ENSP000003535004) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
NEK2P519553, ENSP000003559664I2D: score=1 STRING: ENSP00000355966
FCER1GENSP000002899024STRING: ENSP00000289902
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0045087innate immune response IEA--

CLEC4C for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLEC4C (CLC4C)

1 HMDB Compound for CLEC4C    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

Search CenterWatch for drugs/clinical trials and news about CLEC4C / CLC4C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLEC4C gene (2 alternative transcripts): 
NM_130441.2  NM_203503.1  

Unigene Cluster for CLEC4C:

C-type lectin domain family 4, member C
Hs.351812  [show with all ESTs]
Unigene Representative Sequence: AK122596
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000542353(uc001qth.1) ENST00000354629 ENST00000360345(uc001qtg.1)
ENST00000537530 ENST00000543765 ENST00000540085(uc001qti.1)
miRNA
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLEC4C
SwitchGear 3'UTR luciferase reporter plasmidCLEC4C 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
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Clone
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GenScript: all cDNA clones in your preferred vector (see all 2): CLEC4C (NM_203503)
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Sirion Biotech Customized lentivirus for stable overexpression of CLEC4C 
                     Customized lentivirus expression plasmids for stable overexpression of CLEC4C 
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for CLEC4C
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC4C
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC4C

Additional mRNA sequence: 

AF293615.1 AF325459.1 AF325460.1 AK122596.1 AY358223.1 BC074967.2 BC074968.2 BC102015.1 
BC102016.1 BC102017.1 BC114338.1 

4 DOTS entries:

DT.95155588  DT.101978660  DT.75134426  DT.100742135 

14 AceView cDNA sequences:

BC074967 AF293615 NM_203503 NM_130441 BC074968 AF325459 BX109126 AI183967 
AY358223 AF325460 AK122596 CD707910 AA868502 BQ333717 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4C    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:        -                                             
SP2:                                                      
SP3:                          -                           


ECgene alternative splicing isoforms for CLEC4C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLEC4C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CLEC4C Expression
About this image


See CLEC4C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLEC4C

SOURCE GeneReport for Unigene cluster: Hs.351812

UniProtKB/Swiss-Prot: CLC4C_HUMAN, Q8WTT0
Tissue specificity: Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature
monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not
with TNF-alpha

    SABiosciences Expression via Pathway-Focused PCR Array including CLEC4C: 
          Antigen Presenting Cells in human mouse rat

Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4C

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for CLEC4C gene from 1/2 species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
platypus
(Ornithorhynchus anatinus)
Mammalia --
--
47(a)
1 → many
Contig6405(40503-41705)


ENSEMBL Gene Tree for CLEC4C (if available)
TreeFam Gene Tree for CLEC4C (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CLEC4C gene
CD2072  CLEC17A2  CLEC4E2  ASGR22  CLEC4M2  CLEC4F2  CD2092  CLEC4A2  
FCER22  CLEC10A2  CLEC6A2  ASGR12  CLEC4D2  CLEC4G2  
18/19 SIMAP similar genes for CLEC4C using alignment to 3 protein entries:     CLC4C_HUMAN (see all proteins) (see all similar genes):
CLEC4A    CLEC6A    FCER2    CLEC10A    CLEC2D    CD209
CLEC5A    ASGR1    CLEC4D    KLRD1    KLRC1    NCAN
CLEC4E    CLEC2B    KLRC2    CLEC4M    CLEC2L    VCAN

CLEC4C for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/691 SNPs in CLEC4C are shown (see all 691)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1509762851,2
--7717765(+) TCTCTC/TGGCGA 2 -- us2k10--------
rs1408382341,2
--7717777(+) CTTGTA/GGTCTT 2 -- us2k10--------
rs1502085671,2
--7717783(+) GTCTTA/GCTAGC 2 -- us2k10--------
rs749033221,2
C,F--7717787(+) TGCTAG/CCTTCA 2 -- us2k12Minor allele frequency- C:0.09NA EA 240
rs110556021,2
C,F,A--7717797(+) aggagT/Ggaagc 2 -- us2k110Minor allele frequency- G:0.36NA CSA WA EA 369
rs1468168501,2
--7717807(+) CTACAA/GACTTC 2 -- us2k10--------
rs73160351,2
C,A,H--7717812(+) gacttT/Ccgcgg 2 -- us2k112Minor allele frequency- C:0.06NA WA CSA EA 255
rs1882803761,2
--7717816(+) TCCGCA/GGTATC 2 -- us2k10--------
rs73160361,2
C,A,H--7717821(+) ggtatT/Cacagc 2 -- us2k112Minor allele frequency- C:0.05NA WA CSA EA 255
rs1922166811,2
--7717839(+) AGAACC/TGTGGA 2 -- us2k10--------

HapMap Linkage Disequilibrium report for CLEC4C (7882011 - 7904201 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for CLEC4C:    About this table     
Variant IDTypeSubtypePubMed ID
esv2662383CNV Deletion23128226
esv2422393CNV Duplication17116639
dgv6e196CNV Duplication17116639
dgv5e196CNV Duplication17116639
dgv1354n71CNV Gain21882294
dgv57e55CNV Gain17911159
nsv428270CNV Gain18775914
dgv454e1CNV Complex17122850
dgv455e1CNV Complex17122850

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CLEC4C
DNA2.0 Custom Variant and Variant Library Synthesis for CLEC4C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 606677    OMIM disorders: --

9 diseases for CLEC4C:    About MalaCards
enamel caries    dengue hemorrhagic fever    hemorrhagic fever    herpes simplex
systemic lupus erythematosus    multiple sclerosis    lupus erythematosus    melanoma
endotheliitis


CLEC4C for disorders           About GeneDecksing

Genetic Association Database (GAD): CLEC4C
Human Genome Epidemiology (HuGE) Navigator: CLEC4C (1 document)

Export disorders for CLEC4C gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CLEC4C gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with CLEC4C)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of the gene for a novel C-type lectin (CLECSF7) that maps near the natural killer gene complex on human chromosome 12. (PubMed id 11031109)1, 2, 3, 9 Fernandes M.J.... Calabretta B. (2000)
  2. Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells. (PubMed id 11536172)1, 2, 3 Arce I.... Fernandez-Ruiz E. (2001)
  3. Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (2010)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  6. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. (PubMed id 11748283)1, 2 Dzionek A.... Schmitz J. (2001)
  7. BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. (PubMed id 17850179)1, 9 Cao W....Liu Y.J. (2007)
  8. HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells. (PubMed id 23053572)1 Florentin J....Stranska R. (2012)
  9. Human C-type lectin domain family 4, member C (CLEC4C /BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides. (PubMed id 21880719)1 Riboldi E....Sozzani S. (2011)
  10. Immunohistochemical characterisation of dendritic cel ls in human atherosclerotic lesions: possible pitfalls. (PubMed id 21436634)1 Van VrAc E.A....Bult H. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 170482 HGNC: 13258 AceView: CLECSF7 Ensembl:ENSG00000198178 euGenes: HUgn170482
ECgene: CLEC4C H-InvDB: CLEC4C

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CLEC4C Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00133

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CLEC4C gene:
Search GeneIP for patents involving CLEC4C

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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