Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC4C Gene

protein-coding   GIFtS: 48
GCID: GC12M007882

C-type lectin domain family 4, member C

(Previous names: C-type (calcium dependent, carbohydrate-recognition domain)...)
(Previous symbols: CLECSF11, CLECSF7)
 Explore 8 diseases affiliated with
CLEC4C via our new
 Human Malady Compendium 
Biological research products
for CLEC4C
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 4, Member C1 2     BDCA-22 3
BDCA21 2 3 5     C-Type Lectin Superfamily Member 72 3
CLECSF111 2 3 5     PRO341502
DLEC1 2 3 5     Blood Dendritic Cell Antigen 2 Protein2
CLECSF71 2 3     C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily
Member 112
HECL1 2 3     C-Type Lectin Domain Family 4 Member C2
CD3031 2     Dendritic Cell Lectin B2
C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily
Member 71 2
     Blood Dendritic Cell Antigen 23
Dendritic Lectin2 3     CD303 Antigen3

External Ids:    HGNC: 132581   Entrez Gene: 1704822   Ensembl: ENSG000001981787   OMIM: 6066775   UniProtKB: Q8WTT03   

Export aliases for CLEC4C gene to outside databases

Previous GC identifers: GC12M007776 GC12M007695


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLEC4C:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this
family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling,
glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may
play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for
this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLC4C_HUMAN, Q8WTT0
Function: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for
presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid
dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular
calcium. Does not seem to bind mannose




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC4C gene promoter:
         AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLEC4C promoter sequence
   Search SABiosciences Chromatin IP Primers for CLEC4C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC4C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2-p12.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.2-p12.3

CLEC4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC4C gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M007882:  view genomic region     (about GC identifiers)

Start:
7,882,011 bp from pter      End:
7,904,201 bp from pter
Size:
22,191 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLC4C_HUMAN, Q8WTT0 (See protein sequence)
Recommended Name: C-type lectin domain family 4 member C  
Size: 213 amino acids; 25038 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Probable)
Secondary accessions: D3DUU3 Q3T1C3 Q6UXS8 Q8WXX8
Alternative splicing: 2 isoforms:  Q8WTT0-1   Q8WTT0-2   

Explore the universe of human proteins at neXtProt for CLEC4C: NX_Q8WTT0

CLEC4C Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (2 alternative transcripts): 
NP_569708.1  NP_987099.1  

ENSEMBL proteins: 
 ENSP00000440428   ENSP00000346648   ENSP00000353500   ENSP00000438649   ENSP00000442457  
 ENSP00000445338  

Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: CLEC4C
OriGene Custom Protein Services for CLEC4C 
GenScript Custom Purified and Recombinant Proteins Services for CLEC4C
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for CLEC4C

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--


CLEC4C for ontologies           About GeneDecksing



CLEC4C Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of CLEC4C
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for CLEC4C 
GenScript Custom Superior Antibodies Services for CLEC4C
Search for Antibodies for CLEC4C at Abcam  
Uscn Antibodies for CLEC4C
ThermoFisher Antibodies for CLEC4C

Assay Products for CLEC4C: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CLEC4C
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for CLEC4C


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CLEC4C for domains           About GeneDecksing

4 InterPro domains/families:
 IPR016187 C-type_lectin_fold
 IPR018378 C-type_lectin_CS
 IPR016186 C-type_lectin-like
 IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry Q8WTT0

ProtoNet protein and cluster: Q8WTT0

1 Blocks protein family: IPB002353 Type II antifreeze protein signature

UniProtKB/Swiss-Prot: CLC4C_HUMAN, Q8WTT0
Similarity: Contains 1 C-type lectin domain


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: CLC4C_HUMAN, Q8WTT0
Function: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for
presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid
dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular
calcium. Does not seem to bind mannose

miRNA
Products:
    
Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC4C
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLEC4C
SwitchGear 3'UTR luciferase reporter plasmidCLEC4C 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC4C
OriGene shRNA RFP: CLEC4C
OriGene siRNA: CLEC4C
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC4C

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CLEC4C

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 2): CLEC4C (NM_203503)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC4C
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4C 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CLEC4C
Search LifeMap BioReagents cell lines for CLEC4C

In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4C

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030246carbohydrate binding IEA--


CLEC4C for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for CLEC4C:
 Decreased cilium length after  


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC4C

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for CLEC4C (Q8WTT03 ENSP000003535004) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
NEK2P519553, ENSP000003559664I2D: score=1 STRING: ENSP00000355966
FCER1GENSP000002899024STRING: ENSP00000289902
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0045087innate immune response IEA--


CLEC4C for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLEC4C

1 HMDB Compound for CLEC4C    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
Search CenterWatch for drugs/clinical trials and news about CLEC4C / CLC4C 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLEC4C gene (2 alternative transcripts): 
NM_130441.2  NM_203503.1  

Unigene Cluster for CLEC4C:

C-type lectin domain family 4, member C
Hs.351812  [show with all ESTs]
Unigene Representative Sequence: AK122596
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000542353(uc001qth.1) ENST00000354629 ENST00000360345(uc001qtg.1)
ENST00000537530 ENST00000543765 ENST00000540085(uc001qti.1)

miRNA
Products:
     
Browse 3'-UTR reporter clones for miRNA target validation
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC4C
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLEC4C
SwitchGear 3'UTR luciferase reporter plasmidCLEC4C 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC4C
OriGene shRNA RFP: CLEC4C
OriGene siRNA: CLEC4C
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC4C
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 2): CLEC4C (NM_203503)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC4C
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4C 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC4C
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC4C
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC4C
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC4C

Additional cDNA sequence: 

AF293615.1 AF325459.1 AF325460.1 AK122596.1 AY358223.1 BC074967.2 BC074968.2 BC102015.1 
BC102016.1 BC102017.1 BC114338.1 

4 DOTS entries:

DT.95155588  DT.101978660  DT.75134426  DT.100742135 

14 AceView cDNA sequences:

NM_203503 AF293615 BC074968 NM_130441 BC074967 AF325460 AY358223 BX109126 
AI183967 AF325459 AK122596 AA868502 CD707910 BQ333717 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4C    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:        -                                             
SP2:                                                      
SP3:                          -                           


ECgene alternative splicing isoforms for CLEC4C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLEC4C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See CLEC4C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLEC4C

SOURCE GeneReport for Unigene cluster: Hs.351812

UniProtKB/Swiss-Prot: CLC4C_HUMAN, Q8WTT0
Tissue specificity: Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature
monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with
TNF-alpha

    SABiosciences Expression via Pathway-Focused PCR Array including CLEC4C: 
          Antigen Presenting Cells in human mouse rat

Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC4C
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC4C
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC4C
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC4C
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4C

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CLEC4C gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
zebrafish
(Danio rerio)
Actinopterygii BX682234.36
si:ch73-343l4.56
(see all 41)
si:ch73-343l4.5
(see all 41)
8(a)
36(a)
(see all 41)
many ↔ many
many ↔ many
(see all 41)
10(7530024-7534761)
1(56420677-56430629)


ENSEMBL Gene Tree for CLEC4C (if available)
TreeFam Gene Tree for CLEC4C (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CLEC4C gene
CD2072  CLEC4E2  ASGR22  CLEC4M2  CLEC4F2  CD2092  CLEC10A2  FCER22  
CLEC4A2  CLEC6A2  ASGR12  CLEC4D2  CLEC4G2  
18/20 SIMAP similar genes for CLEC4C using alignment to 3 protein entries:     CLC4C_HUMAN (see all proteins) (see all similar genes):
CLEC4A    CLEC6A    FCER2    CLEC10A    CLEC2D    CD209
CLEC5A    ASGR1    CLEC4D    KLRD1    KLRC1    NCAN
CLEC4E    CLEC2B    KLRC2    CLEC2L    CLEC4M    VCAN

CLEC4C for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/576 NCBI SNPs in CLEC4C are shown (see all 576    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1397502591,2
--7881512(+) GGTTAC/TGGCTT 2 -- ds50010--------
rs1856659911,2
--7881570(+) CACCCA/GTCAGC 2 -- ds50010--------
rs1170135201,2
F,--7881580(+) CTGTCG/AGAAAA 2 -- ds50011Minor allele frequency- A:0.03EA 120
rs1430909551,2
--7881602(+) GTGGCC/TGGGCG 2 -- ds50010--------
rs1873587101,2
--7881603(+) TGGCCA/GGGCGC 2 -- ds50010--------
rs73121061,2
C,F,A,H,--7881640(+) CTTTGC/GGAGGC 2 -- ds50015Minor allele frequency- G:0.33NA CSA 9
rs1922591161,2
--7881671(+) GTCAGC/GAGATC 2 -- ds50010--------
rs73121291,2
C,F,A,H,--7881700(+) ACAGTG/ACAGTG 2 -- ds500111Minor allele frequency- A:0.46NA WA CSA EA 374
rs1401136491,2
--7881809(+) TGAACA/CCGGGA 2 -- ds50010--------
rs1498280591,2
--7881817(+) GGAGGC/TGGAGC 2 -- ds50010--------

HapMap Linkage Disequilibrium report for CLEC4C (7882011 - 7904201 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for CLEC4C
     14 CNVs: 34464 8709 5298 2968 5299 3873 5300 5301 5302 5306 5303 5305 34469 5304
     1 Indel: 39874

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC4C
DNA2.0 Custom Variant and Variant Library Synthesis for CLEC4C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CLEC4C for disorders           About GeneDecksing

OMIM gene information: 606677    OMIM disorders: --

8 diseases for CLEC4C:    About MalaCards
enamel caries    dengue hemorrhagic fever    hemorrhagic fever    systemic lupus erythematosus
lupus erythematosus    herpes simplex    multiple sclerosis    melanoma

Human Genome Epidemiology (HuGE) Navigator: CLEC4C (1 document)

Export disorders for CLEC4C gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CLEC4C gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with CLEC4C)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of the gene for a novel C-type lectin (CLECSF7) that maps near the natural killer gene complex on human chromosome 12. (PubMed id 11031109)1, 2, 3, 9 Fernandes M.J.... Calabretta B. (2000)
  2. Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells. (PubMed id 11536172)1, 2, 3 Arce I.... Fernandez-Ruiz E. (2001)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  5. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. (PubMed id 11748283)1, 2 Dzionek A.... Schmitz J. (2001)
  6. BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. (PubMed id 17850179)1, 9 Cao W....Liu Y.J. (2007)
  7. HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells. (PubMed id 23053572)1 Florentin J....Stranska R. (2012)
  8. Human C-type lectin domain family 4, member C (CLEC4C /BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides. (PubMed id 21880719)1 Riboldi E....Sozzani S. (2011)
  9. Immunohistochemical characterisation of dendritic cel ls in human atherosclerotic lesions: possible pitfalls. (PubMed id 21436634)1 Van VrAc E.A....Bult H. (2011)
  10. Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood. (PubMed id 20888334)1 Van Brussel I....Bult H. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 170482 HGNC: 13258 AceView: CLECSF7 Ensembl:ENSG00000198178 euGenes: HUgn170482
ECgene: CLEC4C H-InvDB: CLEC4C

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CLEC4C Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00133

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CLEC4C gene:
Search GeneIP for patents involving CLEC4C

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
 EMD Millipore Mono- and Polyclonal Antibodies for the study of CLEC4C
 Browse Small Molecules at EMD Millipore
 Browse Kits and Assays available from EMD Millipore
 Browse Purified and Recombinant Proteins at EMD Millipore
 Browse for Gene Knock-down Tools from EMD Millipore
 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
 Browse OriGene Antibodies   OriGene shRNA RFP for CLEC4C  
 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC4C   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC4C  
 OriGene Protein Over-expression Lysate for CLEC4C   Browse OriGene Fluorogenic Cell Assay Kits  
 OriGene siRNA for CLEC4C   Browse 3'-UTR reporter clones for miRNA target validation  
 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4C   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4C  
 Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
 Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
 Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for CLEC4C   OriGene Custom Protein Services for CLEC4C  
 OriGene Custom Immunoassay Development  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLEC4C
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC4C
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC4C
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC4C
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC4C
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC4C
 GenScript Custom Purified and Recombinant Proteins Services for CLEC4C GenScript cDNA clones with any tag delivered in your preferred vector for CLEC4C
 GenScript Custom Assay Services for CLEC4C GenScript Custom Superior Antibodies Services for CLEC4C
 GenScript Custom overexpressing Cell Line Services for CLEC4C CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in CLEC4C promoter
 Search Chromatin IP Primers for CLEC4C
 RT2 qPCR Primer Assay in human, mouse, rat CLEC4C
 Search GNC Networks for CLEC4C
 SABiosciences PCR Arrays including human, mouse, rat CLEC4C
 Search Tocris compounds for CLEC4C
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological cDNA Clones
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Biologicals
 Novus Tissue Slides
 Search for Antibodies for CLEC4C at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for CLEC4C
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 CLEC4C Proteins, Antibodies, CLIAs, and ELISAs
 Search LifeMap BioReagents cell lines for CLEC4C
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4C
 SwitchGear 3'UTR luciferase reporter plasmids for CLEC4C
 SwitchGear Promoter luciferase reporter plasmids for CLEC4C
 ThermoFisher Antibodies for CLEC4C
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4C
       
GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category
VWF
(GIFTS: 73)
von Willebrand factor
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      CLEC4C gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4