CLEC4A Gene
protein-coding GIFtS: 52
GCID: GC12P008278
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C-type lectin domain family 4, member A(Previous names: C-type (calcium dependent, carbohydrate-recognition domain)...)
(Previous symbol: CLECSF6)
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Aliases
for CLEC4A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| C-Type Lectin Domain Family 4, Member A1 2 | | Lectin-Like Immunoreceptor2 3 | | CLECSF61 2 3 5 | | LLIR2 3 | | DCIR1 2 3 5 | | C-Type Lectin DDB272 3 | | DDB271 2 5 | | C-Type Lectin Superfamily Member 62 3 | | C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, SuperfamilyMember 61 2 | | C-Type Lectin Domain Family 4 Member A2 | | Dendritic Cell Immunoreceptor2 3 | | |
Export aliases for CLEC4A gene to outside databasesPrevious GC identifers: GC12P008168 GC12P008169 GC12P008170 GC12P008277 GC12P008087 |
Summaries
for CLEC4A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CLEC4A:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of thisfamily share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling,glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein mayplay a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have beenidentified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in thenatural killer gene complex region. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CLC4A_HUMAN, Q9UMR7Function: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC)differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitorymotifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation
Gene Wiki entry for CLEC4A
|
Genomic Views
for CLEC4A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLEC4A gene promoter:
Nkx3-1 v4 AML1a Pax-2 Nkx3-1 v1 Pax-2a IRF-1 POU3F2 Nkx3-1 v2 Pax-2b Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLEC4A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC4A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13CLEC4A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P008278: view genomic region
(about GC identifiers)
Start:
|
8,276,228 bp from pter |
End:
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8,291,203 bp from pter |
Size:
|
14,976 bases |
Orientation:
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plus strand |
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Proteins
for CLEC4A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLC4A_HUMAN, Q9UMR7 (See
protein sequence)Recommended Name: C-type lectin domain family 4 member A Size: 237 amino acids; 27512 Da
Subunit: May interact with PTPN6 via its ITIM motif
Subcellular location: Membrane; Single-pass type II membrane protein (Probable)
Sequence caution: Sequence=AAL56016.1; Type=Frameshift; Positions=229;
Secondary accessions: Q17R69 Q8WXW9 Q9H2Z9 Q9NS33 Q9UI34Alternative splicing: 4 isoforms: Q9UMR7-1 Q9UMR7-2 Q9UMR7-3 Q9UMR7-4 Explore the universe of human proteins at neXtProt for CLEC4A: NX_Q9UMR7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UMR7
CLEC4A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_057268.1 NP_919429.2 NP_919430.1 NP_919432.1
ENSEMBL proteins: ENSP00000229332 ENSP00000344646 ENSP00000247243 ENSP00000353690 ENSP00000443082
Human Recombinant Protein Products for CLEC4A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
CLEC4A for ontologies About GeneDecksing
CLEC4A Antibody Products:
Assay Products for CLEC4A: |
Protein
Domains /
Families
for CLEC4A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLEC4A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UMR7ProtoNet protein and cluster: Q9UMR7 1 Blocks protein family: IPB002353 Type II antifreeze protein signature
UniProtKB/Swiss-Prot: CLC4A_HUMAN, Q9UMR7Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif(ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2domain of several SH2-containing phosphatasesSimilarity: Contains 1 C-type lectin domain |
Function
for CLEC4A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CLC4A_HUMAN, Q9UMR7Function: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC)differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitorymotifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylationInduction: Isoform 2 mRNA expression is up-regulated by agonists of neutrophils CSF2/GM-CSF, IL3/interleukin-3,IL4/interleukin-4 and IL13/interleukin-13 Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004888 | transmembrane signaling receptor activity |
TAS | 10438934 | | GO:0030246 | carbohydrate binding |
IEA | -- |
CLEC4A for ontologies About GeneDecksing
Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Clec4a2):
CLEC4A for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Clec4a2tm1Psob for CLEC4A
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4A (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4A (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): CLEC4A (NM_016184) | |  | Sino Biological Human cDNA Clone for CLEC4A | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLEC4A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4A |
|
Pathways & Interactions
for CLEC4A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC4A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for CLEC4A (Q9UMR73 ENSP000002293324) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
CLEC4A for ontologies About GeneDecksing
|
Drugs & Compounds
for CLEC4A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CLEC4A for compounds About GeneDecksing
 Browse Tocris compounds for CLEC4A
1 HMDB Compound for CLEC4A About this table
10/24 Novoseek chemical compound relationships for CLEC4A gene (see all 24) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| n,n-diacetylchitobiose |
69.5 |
1 |
16116234 (1) |
| mannose |
61.6 |
6 |
18310920 (1), 12972549 (1), 10093645 (1), 12473263 (1) (see all 6) |
| n-acetylglucosamine |
56.8 |
4 |
8757624 (1), 9226570 (1), 18310920 (1), 8157977 (1) |
| aminosugars |
52.2 |
2 |
1470681 (1), 8082725 (1) |
| galactose |
50.8 |
3 |
18310920 (1), 2148949 (1), 8869505 (1) |
| carbohydrates |
47.1 |
7 |
1829437 (1), 1831224 (1), 9498072 (1), 8621059 (1) (see all 6) |
| polysaccharide |
45.3 |
9 |
19307599 (1), 9099704 (1), 10898932 (1), 8688417 (1) (see all 8) |
| sodium periodate |
44.8 |
2 |
9701801 (1), 1993708 (1) |
| sialic acid |
39.5 |
4 |
17981653 (1), 8168943 (1), 9701801 (1) |
| superoxide |
20.8 |
1 |
14967724 (1) |
Search CenterWatch for drugs/clinical trials and news about CLEC4A / CLC4A
|
Transcripts
for CLEC4A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLEC4A gene (4 alternative transcripts): NM_016184.3 NM_194447.2 NM_194448.2 NM_194450.2 Unigene Cluster for CLEC4A: C-type lectin domain family 4, member A Hs.504657 [show with all ESTs]Unigene Representative Sequence: AF3286845 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000229332(uc001qtz.1 uc009zga.1 uc001qub.1 uc001quc.1 uc009zgb.1)
ENST00000345999 ENST00000352620 ENST00000360500 ENST00000546339
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4A (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4A (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): CLEC4A (NM_016184) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLEC4A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4A |
Additional cDNA sequence: AF067800.1 AF109146.1 AF200738.1 AF328684.1 AJ133532.1 BC074822.2 BC074874.2 BC117439.1 BC117441.1 EU196761.1 5 DOTS entries: DT.75100530 DT.100742380 DT.121173733 DT.91737632 DT.91737633 24/31 AceView cDNA sequences (see all 31): NM_194450 BC074822 BX106333 NM_194447 AA677149 NM_194448 NM_016184 BC074874 AA446401 AF328684 AF200738 AI338670 AA380065 BQ002993 AV716802 AV711676 AI333747 AI949910 CD691817 AF067800 AF109146 AA418441 AJ133532 AV716725
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4A About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for CLEC4A
|
Expression
for CLEC4A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLEC4A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTCTCTCTT
About this image
See CLEC4A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLEC4A
SOURCE GeneReport for Unigene cluster: Hs.504657
UniProtKB/Swiss-Prot: CLC4A_HUMAN, Q9UMR7Tissue specificity: Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha,IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressedpreferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities inspleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC,monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducingits maturation (e.g. CD40 ligand, LPS, and TNF alpha)
SABiosciences Custom PCR Arrays for CLEC4A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC4A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC4A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4A |
Orthologs
for CLEC4A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CLEC4A gene from 1/8 species (see all 8) About this table
ENSEMBL Gene Tree for CLEC4A (if available)
TreeFam Gene Tree for CLEC4A (if available) |
Paralogs
for CLEC4A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLEC4A gene
- CD2072 CLEC4E2 ASGR22 CLEC4M2 CLEC4F2 CD2092 CLEC10A2 FCER22
- CLEC6A2 ASGR12 CLEC4C2 CLEC4D2 CLEC4G2
5 SIMAP similar genes for CLEC4A using alignment to 2 protein entries: CLC4A_HUMAN (see all proteins):CLEC4C CLEC6A CLEC4D CLEC4E CLEC10A
CLEC4A for paralogs About GeneDecksing
|
Genomic Variants
for CLEC4A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLEC4A (8276228 - 8291203 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CLEC4A
3 CNVs: 2969 3873 34469 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC4A |
|
Disorders
/ Diseases
for CLEC4A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLEC4A for disorders About GeneDecksing
OMIM gene information: 605306
OMIM disorders: --
20/21  diseases for CLEC4A (see all 21): About MalaCardspneumonic plague pre-eclampsia myocardial infarction acute myocardial infarction
coronary heart disease rheumatoid arthritis pulmonary edema plague
vascular disease was-related disorders eclampsia diabetes mellitus
osteoarthritis hypercholesterolemia arthritis atherosclerosis
alzheimer's disease influenza melanoma pneumonia
10/12 Novoseek disease relationships for CLEC4A gene (see all 12) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| atherosclerosis |
56.6 |
15 |
15727724 (2), 17022953 (1), 18000963 (1), 20033826 (1) (see all 13) |
| atherosclerotic plaque |
47 |
3 |
18092947 (1), 16146427 (1), 15961718 (1) |
| cardiovascular diseases |
21.9 |
2 |
20073134 (1), 14675775 (1) |
| inflammation |
20.6 |
4 |
11564777 (1), 11994513 (1), 18067591 (1), 19252093 (1) |
| vascular diseases |
14.4 |
1 |
20203069 (1) |
| necrosis |
13.3 |
6 |
18067591 (1), 8303299 (1), 8323280 (1), 10571070 (1) (see all 6) |
| osteoarthritis |
0.764 |
1 |
16945559 (1) |
| rheumatoid arthritis |
0 |
1 |
15529384 (1) |
| tumors |
0 |
7 |
8303299 (1), 8323280 (1), 10571070 (1), 1560214 (1) (see all 6) |
| allergy |
0 |
1 |
2054423 (1) |
Export disorders for CLEC4A gene to outside databases
|
Publications
for CLEC4A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLEC4A gene, integrated from 9 sources (see all 247):
(articles sorted by number of sources associating them with CLEC4A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. (PubMed id 10438934)1, 2, 3, 9 Bates E.E.M.... Saeland S. (1999)
- The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation. (PubMed id 11994513)1, 2, 9 Richard M.... Beaulieu A.D. (2002)
- Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants. (PubMed id 11178971)1, 2, 9 Huang X.... Cao X. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Association of arthritis with a gene complex encoding C-type lectin-like receptors. (PubMed id 17665455)1, 9 Lorentzen J.C....Fossum S. (2007)
- A replication study confirms the association of dendri tic cell immunoreceptor (DCIR) polymorphisms with ACPA - negative RA in a large Asian cohort. (PubMed id 22829930)1 Guo J....Li Z. (2012)
- Single nucleotide polymorphisms in C-type lectin genes , clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pat hogenesis of inflammatory bowel diseases. (PubMed id 22664939)1 Wolfkamp S.C....te Velde A.A. (2012)
- DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway. (PubMed id 21536857)1 Lambert A.A....Tremblay M.J. (2011)
- Cross-priming CD8+ T cells by targeting antigens to h uman dendritic cells through DCIR. (PubMed id 20530286)1 Klechevsky E....Banchereau J. (2010)
- DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production. (PubMed id 19028959)1 Meyer-Wentrup F....Adema G.J. (2009)
|
External Searches for CLEC4A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CLEC4A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLEC4A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLEC4A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLEC4A | Pharmacogenomics, SNPs, Pathways | | Functional Glycomics Gateway - Glycan Binding | http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00137 |
|
| | |
About This Section
| Patent Information for CLEC4A gene:
Search GeneIP for patents involving CLEC4A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CLEC4A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLEC4A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC4A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC4A | | | OriGene Protein Over-expression Lysate for CLEC4A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLEC4A | | OriGene 3'-UTR Clone for CLEC4A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC4A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLEC4A | | OriGene Custom Protein Services for CLEC4A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLEC4A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC4A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC4A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC4A |
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| | | | Search Tocris compounds for CLEC4A |
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 | | | CLEC4A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4A |
|  |  |  |  | | | | ThermoFisher Antibodies for CLEC4A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4A |
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