Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CLEC4A Gene

protein-coding   GIFtS: 55
GCID: GC12P008278

C-Type Lectin Domain Family 4, Member A

(Previous names: C-type (calcium dependent, carbohydrate-recognition domain)...)
(Previous symbol: CLECSF6)
  See CLEC4A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
C-Type Lectin Domain Family 4, Member A1 2     LLIR2 3
CLECSF61 2 3 5     C-Type Lectin DDB272 3
DCIR2 3 5     C-Type Lectin Superfamily Member 62 3
C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin,
Superfamily Member 61 2
     DDB272 5
Dendritic Cell Immunoreceptor2 3     C-Type Lectin Domain Family 4 Member A2
Lectin-Like Immunoreceptor2 3     

External Ids:    HGNC: 132571   Entrez Gene: 508562   Ensembl: ENSG000001117297   OMIM: 6053065   UniProtKB: Q9UMR73   

Export aliases for CLEC4A gene to outside databases

Previous GC identifers: GC12P008168 GC12P008169 GC12P008170 GC12P008277 GC12P008087


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CLEC4A Gene:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this
family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling,
glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein
may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have
been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome
12p13 in the natural killer gene complex region. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLEC4A Gene:
CLEC4A (C-type lectin domain family 4, member A) is a protein-coding gene. Diseases associated with CLEC4A include pneumonic plague, and coronary artery disease. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CD207.

UniProtKB/Swiss-Prot: CLC4A_HUMAN, Q9UMR7
Function: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC)
differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory
motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation

Gene Wiki entry for CLEC4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLEC4A gene promoter:
         Nkx3-1 v4   AML1a   Pax-2   Nkx3-1 v1   Pax-2a   IRF-1   POU3F2   Nkx3-1 v2   Pax-2b   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC4A promoter sequence
   Search Chromatin IP Primers for CLEC4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

CLEC4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC4A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P008278:  view genomic region     (about GC identifiers)

Start:
8,276,228 bp from pter      End:
8,291,203 bp from pter
Size:
14,976 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CLC4A_HUMAN, Q9UMR7 (See protein sequence)
Recommended Name: C-type lectin domain family 4 member A  
Size: 237 amino acids; 27512 Da
Subunit: May interact with PTPN6 via its ITIM motif
Sequence caution: Sequence=AAL56016.1; Type=Frameshift; Positions=229;
Secondary accessions: Q17R69 Q8WXW9 Q9H2Z9 Q9NS33 Q9UI34
Alternative splicing: 4 isoforms:  Q9UMR7-1   Q9UMR7-2   Q9UMR7-3   Q9UMR7-4   

Explore the universe of human proteins at neXtProt for CLEC4A: NX_Q9UMR7

Explore proteomics data for CLEC4A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn185
  • Modification sites at PhosphoSitePlus

  • See CLEC4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_057268.1  NP_919429.2  NP_919430.1  NP_919432.1  

    ENSEMBL proteins: 
     ENSP00000229332   ENSP00000344646   ENSP00000247243   ENSP00000353690   ENSP00000443082  

    CLEC4A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CLEC4A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CLEC4A
    GenScript Custom Purified and Recombinant Proteins Services for CLEC4A
    Novus Biologicals CLEC4A Protein
    Novus Biologicals CLEC4A Lysates
    Sino Biological Recombinant Protein for CLEC4A
    Sino Biological Cell Lysate for CLEC4A
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLEC4A

     
    Search eBioscience for Proteins for CLEC4A 

    CLEC4A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CLEC4A (DCIR/CLEC4A)
    OriGene Antibodies for CLEC4A
    OriGene Custom Antibody Services for CLEC4A
    Novus Biologicals CLEC4A Antibodies
    Abcam antibodies for CLEC4A
    Cloud-Clone Corp. Antibodies for CLEC4A
    ThermoFisher Antibodies for CLEC4A
    Search LSBio for Antibodies for CLEC4A

    CLEC4A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CLEC4A
    R&D Systems Proteome Profiler Antibody Arrays for CLEC4A (DCIR/CLEC4A)
    GenScript Custom Assay Services for CLEC4A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLEC4A
    Cloud-Clone Corp. CLIAs for CLEC4A
    Search eBioscience for ELISAs for CLEC4A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CLEC: C-type lectin domain containing

    4 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q9UMR7

    ProtoNet protein and cluster: Q9UMR7

    1 Blocks protein domain: IPB002353 Type II antifreeze protein signature

    UniProtKB/Swiss-Prot: CLC4A_HUMAN, Q9UMR7
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind
    the SH2 domain of several SH2-containing phosphatases
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with CLEC4A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLC4A_HUMAN, Q9UMR7
    Function: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC)
    differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory
    motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation
    Induction: Isoform 2 mRNA expression is up-regulated by agonists of neutrophils CSF2/GM-CSF, IL3/interleukin-3,
    IL4/interleukin-4 and IL13/interleukin-13

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS10438934
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with CLEC4A           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Clec4a2):
     no phenotypic analysis 

    Find genes that share phenotypes with CLEC4A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Clec4a2tm1.1Cfg for CLEC4A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLEC4A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLEC4A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC4A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLEC4A

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CLEC4A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CLEC4A
    SwitchGear 3'UTR luciferase reporter plasmidCLEC4A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLEC4A
    Predesigned siRNA for gene silencing in human, mouse, rat CLEC4A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLEC4A

    Clone
    Products:
         
    OriGene clones in human, mouse for CLEC4A (see all 22)
    OriGene ORF clones in mouse, rat for CLEC4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CLEC4A (NM_016184)
    Sino Biological Human cDNA Clone for CLEC4A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CLEC4A
    Browse ESI BIO Cell Lines and PureStem Progenitors for CLEC4A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CLC4A_HUMAN, Q9UMR7: Membrane; Single-pass type II membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS10438934

    Find genes that share ontologies with CLEC4A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CLEC4A About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CLEC4A
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLEC4A
    Interactions:

        Search GeneGlobe Interaction Network for CLEC4A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CLEC4A (Q9UMR73 ENSP000002293324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293503, ENSP000003915924I2D: score=1 STRING: ENSP00000391592
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS10438934
    GO:0007166cell surface receptor signaling pathway TAS10438934
    GO:0045087innate immune response IEA--

    Find genes that share ontologies with CLEC4A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLEC4A (CLC4A)

    1 HMDB Compound for CLEC4A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for CLEC4A gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n,n-diacetylchitobiose 69.5 1 16116234 (1)
    mannose 61.6 6 18310920 (1), 12972549 (1), 10093645 (1), 12473263 (1) (see all 6)
    n-acetylglucosamine 56.8 4 8757624 (1), 9226570 (1), 18310920 (1), 8157977 (1)
    aminosugars 52.2 2 1470681 (1), 8082725 (1)
    galactose 50.8 3 18310920 (1), 2148949 (1), 8869505 (1)
    carbohydrates 47.1 7 1829437 (1), 1831224 (1), 9498072 (1), 8621059 (1) (see all 6)
    polysaccharide 45.3 9 19307599 (1), 9099704 (1), 10898932 (1), 8688417 (1) (see all 8)
    sodium periodate 44.8 2 9701801 (1), 1993708 (1)
    sialic acid 39.5 4 17981653 (1), 8168943 (1), 9701801 (1)
    superoxide 20.8 1 14967724 (1)



    Find genes that share compounds with CLEC4A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CLEC4A gene (4 alternative transcripts): 
    NM_016184.3  NM_194447.2  NM_194448.2  NM_194450.2  

    Unigene Cluster for CLEC4A:

    C-type lectin domain family 4, member A
    Hs.504657  [show with all ESTs]
    Unigene Representative Sequence: AF328684
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229332(uc001qtz.1 uc009zga.1 uc001qub.1 uc001quc.1 uc009zgb.1)
    ENST00000345999 ENST00000352620 ENST00000360500 ENST00000546339
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLEC4A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CLEC4A
    SwitchGear 3'UTR luciferase reporter plasmidCLEC4A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CLEC4A
    Predesigned siRNA for gene silencing in human, mouse, rat CLEC4A
    Clone
    Products:
         
    OriGene clones in human, mouse for CLEC4A (see all 22)
    OriGene ORF clones in mouse, rat for CLEC4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CLEC4A (NM_016184)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CLEC4A
    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC4A
      QuantiTect SYBR Green Assays in human, mouse, rat CLEC4A
      QuantiFast Probe-based Assays in human, mouse, rat CLEC4A

    Additional mRNA sequence: 

    AF067800.1 AF109146.1 AF200738.1 AF328684.1 AJ133532.1 BC074822.2 BC074874.2 BC117439.1 
    BC117441.1 EU196761.1 

    5 DOTS entries:

    DT.75100530  DT.100742380  DT.121173733  DT.91737632  DT.91737633 

    Selected AceView cDNA sequences (see all 31):

    BC074874 AA677149 NM_016184 NM_194447 BC074822 AA446401 NM_194450 BX106333 
    NM_194448 AV716802 AV711676 AI338670 AJ133532 AA418441 CD691817 BQ002993 
    AI333747 AF109146 AF067800 AA380065 AF200738 AI949910 AF328684 CD683961 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                                                            
    SP2:                          -                                 
    SP3:                    -     -                                 


    ECgene alternative splicing isoforms for CLEC4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CLEC4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCTCTCTT
    CLEC4A Expression
    About this image


    CLEC4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
    CLEC4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLEC4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504657

    UniProtKB/Swiss-Prot: CLC4A_HUMAN, Q9UMR7
    Tissue specificity: Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF
    alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed
    preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate
    quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting
    cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by
    signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha)

        Custom PCR Arrays for CLEC4A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CLEC4A
    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC4A
    QuantiTect SYBR Green Assays in human, mouse, rat CLEC4A
    QuantiFast Probe-based Assays in human, mouse, rat CLEC4A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CLEC4A gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec4a21 , 5 C-type lectin domain family 4, member a21, 5 70.07(n)1
    54.89(a)1
      6 (58.18 cM)5
    268881  NM_011999.41  NP_036129.11 
     1231064285 


    ENSEMBL Gene Tree for CLEC4A (if available)
    TreeFam Gene Tree for CLEC4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CLEC4A gene
    CD2072  CLEC17A2  CLEC4E2  ASGR22  CLEC4M2  CLEC4F2  CD2092  FCER22  
    CLEC10A2  CLEC6A2  ASGR12  CLEC4C2  CLEC4D2  CLEC4G2  
    5 SIMAP similar genes for CLEC4A using alignment to 2 protein entries:     CLC4A_HUMAN (see all proteins):
    CLEC4C    CLEC6A    CLEC4D    CLEC4E    CLEC10A

    Find genes that share paralogs with CLEC4A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CLEC4A (see all 306)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826118341,2
    --8274419(+) TGTATA/GAGGTT 4 -- us2k10--------
    rs1457293751,2
    --8274447(+) AGAGTA/CGCAAA 4 -- us2k10--------
    rs795703551,2
    C,F--8274448(+) GAGTCG/ACAAAT 4 -- us2k11Minor allele frequency- A:0.12WA 118
    rs1489311851,2
    --8274499(+) CAGCAC/TGTGGG 4 -- us2k10--------
    rs1437925981,2
    --8274650(+) TCCATA/GTGGTG 4 -- us2k10--------
    rs1477509221,2
    --8274658(+) GTGGGA/GTAGCC 4 -- us2k10--------
    rs19904761,2
    C,F,H--8274736(-) CTGACA/TCTCCA 4 -- us2k19Minor allele frequency- T:0.05MN NS EA NA WA 724
    rs768664161,2
    C,F--8274820(+) AGGAGG/ATGGTC 4 -- us2k11Minor allele frequency- A:0.03NA 120
    rs762156231,2
    C,F--8274844(+) AGCCCG/AGTGAG 4 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1425213281,2
    --8274889(+) ACCCAC/TAGGGT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLEC4A (8276228 - 8291203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CLEC4A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428270CNV Gain18775914
    dgv459e1CNV Complex17122850
    dgv461e1CNV Complex17122850
    dgv455e1CNV Complex17122850
    dgv460e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLEC4A
    DNA2.0 Custom Variant and Variant Library Synthesis for CLEC4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605306    OMIM disorders: --

    2 diseases for CLEC4A:    
    About MalaCards
    pneumonic plague    coronary artery disease

    1 disease from the University of Copenhagen DISEASES database for CLEC4A:
    Pneumonic plague

    Find genes that share disorders with CLEC4A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CLEC4A gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 56.6 15 15727724 (2), 17022953 (1), 18000963 (1), 20033826 (1) (see all 13)
    atherosclerotic plaque 47 3 18092947 (1), 16146427 (1), 15961718 (1)
    cardiovascular diseases 21.9 2 20073134 (1), 14675775 (1)
    inflammation 20.6 4 11564777 (1), 11994513 (1), 18067591 (1), 19252093 (1)
    vascular diseases 14.4 1 20203069 (1)
    necrosis 13.3 6 18067591 (1), 8303299 (1), 8323280 (1), 10571070 (1) (see all 6)
    osteoarthritis 0.764 1 16945559 (1)
    rheumatoid arthritis 0 1 15529384 (1)
    tumors 0 7 8303299 (1), 8323280 (1), 10571070 (1), 1560214 (1) (see all 6)
    allergy 0 1 2054423 (1)


    Export disorders for CLEC4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CLEC4A gene, integrated from 10 sources (see all 247):
    (articles sorted by number of sources associating them with CLEC4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. (PubMed id 10438934)1, 2, 3, 9 Bates E.E.M.... Saeland S. (J. Immunol. 1999)
    2. The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation. (PubMed id 11994513)1, 2, 9 Richard M.... Beaulieu A.D. (J. Leukoc. Biol. 2002)
    3. Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants. (PubMed id 11178971)1, 2, 9 Huang X.... Cao X. (Biochem. Biophys. Res. Commun. 2001)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Association of arthritis with a gene complex encoding C-type lectin-like receptors. (PubMed id 17665455)1, 9 Lorentzen J.C....Fossum S. (Arthritis Rheum. 2007)
    6. A replication study confirms the association of dendritic cell immunoreceptor (DCIR) polymorphisms with ACPA - negative RA in a large Asian cohort. (PubMed id 22829930)1 Guo J....Li Z. (PLoS ONE 2012)
    7. Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases. (PubMed id 22664939)1 Wolfkamp S.C....te Velde A.A. (amp 2012)
    8. DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway. (PubMed id 21536857)1 Lambert A.A....Tremblay M.J. (Blood 2011)
    9. Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR. (PubMed id 20530286)1 Klechevsky E....Banchereau J. (Blood 2010)
    10. DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production. (PubMed id 19028959)1 Meyer-Wentrup F....Adema G.J. (J. Leukoc. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 50856 HGNC: 13257 AceView: CLECSF6 Ensembl:ENSG00000111729 euGenes: HUgn50856
    ECgene: CLEC4A H-InvDB: CLEC4A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CLEC4A Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00137

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CLEC4A gene:
    Search GeneIP for patents involving CLEC4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CLEC4A (DCIR/CLEC4A)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for CLEC4A (DCIR/CLEC4A)  
     OriGene Antibodies for CLEC4A   OriGene RNAi products in human, mouse, rat for CLEC4A  
     OriGene qPCR primer pairs and template standards for CLEC4A   OriGene Protein Over-expression Lysate for CLEC4A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CLEC4A  
     OriGene qSTAR qPCR primer pairs in human, mouse for CLEC4A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CLEC4A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLEC4A   OriGene Custom Protein Services for CLEC4A  

     
     
     Block miRNA regulation of human, mouse, rat CLEC4A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CLEC4A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC4A Predesigned siRNA for gene silencing in human, mouse, rat CLEC4A
     QuantiFast Probe-based Assays in human, mouse, rat CLEC4A QuantiTect SYBR Green Assays in human, mouse, rat CLEC4A
     Custom PCR Arrays for CLEC4A Search Chromatin IP Primers for CLEC4A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC4A  Search GeneGlobe Interaction Network for CLEC4A
     Regulatory tfbs in CLEC4A promoter
     GenScript Custom Purified and Recombinant Proteins Services for CLEC4A GenScript cDNA clones with any tag delivered in your preferred vector for CLEC4A
     GenScript Custom Assay Services for CLEC4A GenScript Custom overexpressing Cell Line Services for CLEC4A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CLEC4A (CLC4A)
     Proteins for CLEC4A
     Cell Lysates for CLEC4A
     cDNA Clones for CLEC4A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CLEC4A antibodies
     CLEC4A proteins
     CLEC4A lysates
     Antibodies for CLEC4A
     See all of Abcam's Antibodies, Kits and Proteins for CLEC4A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CLEC4A
     Antibodies for CLEC4A
     ELISAs for CLEC4A
     CLIAs for CLEC4A



     Browse ESI BIO Cell Lines and PureStem Progenitors for CLEC4A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4A
     SwitchGear 3'UTR luciferase reporter plasmids for CLEC4A
     SwitchGear Promoter luciferase reporter plasmids for CLEC4A
     ThermoFisher Antibodies for CLEC4A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC4A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLEC4A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLEC4A
     Search LSBio for Antibodies for CLEC4A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CLEC4A
      Search eBioscience for proteins for CLEC4A
      Search eBioscience for elisas for CLEC4A
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CLEC4A gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4