Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLEC4A Gene

Aliases for CLEC4A Gene

  • C-Type Lectin Domain Family 4, Member A 2 3
  • CLECSF6 3 4 6
  • DCIR 3 4 6
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 6 2 3
  • C-Type Lectin Superfamily Member 6 3 4
  • Dendritic Cell Immunoreceptor 3 4
  • Lectin-Like Immunoreceptor 3 4
  • C-Type Lectin DDB27 3 4
  • DDB27 3 6
  • LLIR 3 4
  • C-Type Lectin Domain Family 4 Member A 3
  • HDCGC13P 3

External Ids for CLEC4A Gene

Previous Symbols for CLEC4A Gene

  • CLECSF6

Summaries for CLEC4A Gene

Entrez Gene Summary for CLEC4A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLEC4A Gene

CLEC4A (C-Type Lectin Domain Family 4, Member A) is a Protein Coding gene. Diseases associated with CLEC4A include pneumonic plague. Among its related pathways are NOD-like Receptor Signaling Pathways. GO annotations related to this gene include carbohydrate binding and transmembrane signaling receptor activity. An important paralog of this gene is CLEC4D.

UniProtKB/Swiss-Prot for CLEC4A Gene

  • May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.

Gene Wiki entry for CLEC4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC4A Gene

Genomics for CLEC4A Gene

Genomic Location for CLEC4A Gene

Start:
8,123,632 bp from pter
End:
8,138,607 bp from pter
Size:
14,976 bases
Orientation:
Plus strand

Genomic View for CLEC4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC4A Gene

Regulatory Elements for CLEC4A Gene

Proteins for CLEC4A Gene

  • Protein details for CLEC4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMR7-CLC4A_HUMAN
    Recommended name:
    C-type lectin domain family 4 member A
    Protein Accession:
    Q9UMR7
    Secondary Accessions:
    • Q17R69
    • Q8WXW9
    • Q9H2Z9
    • Q9NS33
    • Q9UI34

    Protein attributes for CLEC4A Gene

    Size:
    237 amino acids
    Molecular mass:
    27512 Da
    Quaternary structure:
    • May interact with PTPN6 via its ITIM motif
    SequenceCaution:
    • Sequence=AAL56016.1; Type=Frameshift; Positions=229; Evidence={ECO:0000305};

    Alternative splice isoforms for CLEC4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC4A Gene

Proteomics data for CLEC4A Gene at MOPED

Post-translational modifications for CLEC4A Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn185

Other Protein References for CLEC4A Gene

No data available for DME Specific Peptides for CLEC4A Gene

Domains for CLEC4A Gene

Gene Families for CLEC4A Gene

HGNC:
  • CLEC :C-type lectin domain containing

UniProtKB/Swiss-Prot:

CLC4A_HUMAN
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases:
    • Q9UMR7
  • Contains 1 C-type lectin domain.:
    • Q9UMR7
genes like me logo Genes that share domains with CLEC4A: view

Function for CLEC4A Gene

Molecular function for CLEC4A Gene

UniProtKB/Swiss-Prot Function: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.
UniProtKB/Swiss-Prot Induction: Isoform 2 mRNA expression is up-regulated by agonists of neutrophils CSF2/GM-CSF, IL3/interleukin-3, IL4/interleukin-4 and IL13/interleukin-13.

Gene Ontology (GO) - Molecular Function for CLEC4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10438934
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC4A: view

Phenotypes for CLEC4A Gene

MGI mutant phenotypes for CLEC4A:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CLEC4A: view

Animal Models for CLEC4A Gene

MGI Knock Outs for CLEC4A:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CLEC4A Gene

Localization for CLEC4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC4A Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC4A Gene COMPARTMENTS Subcellular localization image for CLEC4A gene
Compartment Confidence
plasma membrane 4
cytosol 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CLEC4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10438934
genes like me logo Genes that share ontologies with CLEC4A: view

Pathways for CLEC4A Gene

genes like me logo Genes that share pathways with CLEC4A: view

Pathways by source for CLEC4A Gene

Interacting Proteins for CLEC4A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000229332%0d%0a9606.ENSP00000391592%0d%0a
Selected Interacting proteins: Q9UMR7-CLC4A_HUMAN ENSP00000229332 for CLEC4A Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CLEC4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0007155 cell adhesion TAS 10438934
GO:0007166 cell surface receptor signaling pathway TAS 10438934
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with CLEC4A: view

Compounds for CLEC4A Gene

(1) HMDB Compounds for CLEC4A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(24) Novoseek inferred chemical compound relationships for CLEC4A Gene

Compound -log(P) Hits PubMed IDs
n,n-diacetylchitobiose 69.5 1
mannose 61.6 6
n-acetylglucosamine 56.8 4
aminosugars 52.2 2
galactose 50.8 3
genes like me logo Genes that share compounds with CLEC4A: view

Transcripts for CLEC4A Gene

Unigene Clusters for CLEC4A Gene

C-type lectin domain family 4, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: -
SP3: - -

Relevant External Links for CLEC4A Gene

GeneLoc Exon Structure for
CLEC4A
ECgene alternative splicing isoforms for
CLEC4A

Expression for CLEC4A Gene

mRNA expression in normal human tissues for CLEC4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC4A Gene

This gene is overexpressed in Whole Blood (25.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CLEC4A Gene

SOURCE GeneReport for Unigene cluster for CLEC4A Gene Hs.504657

mRNA Expression by UniProt/SwissProt for CLEC4A Gene

Q9UMR7-CLC4A_HUMAN
Tissue specificity: Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha).
genes like me logo Genes that share expressions with CLEC4A: view

Orthologs for CLEC4A Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLEC4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC4A 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLEC4A 36
  • 75.54 (n)
  • 62.23 (a)
CLEC4A 37
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC4A 36
  • 77.54 (n)
  • 63.83 (a)
mouse
(Mus musculus)
Mammalia Clec4a1 37
  • 51 (a)
OneToMany
Clec4a2 36
  • 70.07 (n)
  • 54.89 (a)
Clec4a2 16
Clec4a2 37
  • 49 (a)
OneToMany
Clec4a3 37
  • 49 (a)
OneToMany
Clec4a4 37
  • 51 (a)
OneToMany
Clec4b1 37
  • 45 (a)
OneToMany
Clec4b2 37
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 42 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Clec4a 36
  • 72.08 (n)
  • 55.13 (a)
Species with no ortholog for CLEC4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC4A Gene

ENSEMBL:
Gene Tree for CLEC4A (if available)
TreeFam:
Gene Tree for CLEC4A (if available)

Paralogs for CLEC4A Gene

Selected SIMAP similar genes for CLEC4A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLEC4A: view

Variants for CLEC4A Gene

Sequence variations from dbSNP and Humsavar for CLEC4A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1133103 -- 8,138,189(+) TTGTG(C/T)TAAAT reference, synonymous-codon
rs1133104 -- 8,138,526(+) ACACA(G/T)GGAGA utr-variant-3-prime
rs1990476 -- 8,122,140(-) CTGAC(A/T)CTCCA upstream-variant-2KB
rs2015596 -- 8,122,530(-) CTGCG(C/T)GGATG upstream-variant-2KB
rs2024301 - 8,125,585(-) TTTTG(A/T)GAGGG reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC4A Gene

Variant ID Type Subtype PubMed ID
dgv455e1 CNV Complex 17122850
nsv428270 CNV Gain 18775914
dgv459e1 CNV Complex 17122850
dgv460e1 CNV Complex 17122850
dgv461e1 CNV Complex 17122850

Relevant External Links for CLEC4A Gene

HapMap Linkage Disequilibrium report
CLEC4A

Disorders for CLEC4A Gene

(1) MalaCards Diseases for CLEC4A Gene

Search for CLEC4A Gene in MalaCards »

(1) University of Copenhagen DISEASES for CLEC4A Gene

(12) Novoseek inferred disease relationships for CLEC4A Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 56.6 14
atherosclerotic plaque 47 3
cardiovascular diseases 21.9 2
inflammation 20.6 4
vascular diseases 14.4 1
genes like me logo Genes that share disorders with CLEC4A: view

No data available for UniProtKB/Swiss-Prot for CLEC4A Gene

Publications for CLEC4A Gene

  1. APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. (PMID: 10438934) Bates E.E.M. … Saeland S. (J. Immunol. 1999) 2 3 4 23
  2. Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants. (PMID: 11178971) Huang X. … Cao X. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  3. The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation. (PMID: 11994513) Richard M. … Beaulieu A.D. (J. Leukoc. Biol. 2002) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Association of arthritis with a gene complex encoding C-type lectin-like receptors. (PMID: 17665455) Lorentzen J.C. … Fossum S. (Arthritis Rheum. 2007) 3 23

Products for CLEC4A Gene

  • antibodies-online proteins for CLEC4A
  • antibodies-online antibodies for CLEC4A
  • antibodies-online kits for CLEC4A

Sources for CLEC4A Gene

Back to Top

Content