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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC4A Gene

protein-coding   GIFtS: 56
GCID: GC12P008278

C-Type Lectin Domain Family 4, Member A

(Previous names: C-type (calcium dependent, carbohydrate-recognition domain)...)
(Previous symbol: CLECSF6)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 4, Member A1 2     LLIR2 3
CLECSF61 2 3 5     C-Type Lectin DDB272 3
DCIR2 3 5     C-Type Lectin Superfamily Member 62 3
C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin,
Superfamily Member 61 2
     DDB272 5
Dendritic Cell Immunoreceptor2 3     C-Type Lectin Domain Family 4 Member A2
Lectin-Like Immunoreceptor2 3     

External Ids:    HGNC: 132571   Entrez Gene: 508562   Ensembl: ENSG000001117297   OMIM: 6053065   UniProtKB: Q9UMR73   

Export aliases for CLEC4A gene to outside databases

Previous GC identifers: GC12P008168 GC12P008169 GC12P008170 GC12P008277 GC12P008087


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLEC4A Gene:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this
family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling,
glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein
may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have
been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome
12p13 in the natural killer gene complex region. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLEC4A Gene: 
CLEC4A (C-type lectin domain family 4, member A) is a protein-coding gene. Diseases associated with CLEC4A include pneumonic plague, and plague, and among its related super-pathways are Inflammasome Activation Pathways. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CD207.

UniProtKB/Swiss-Prot: CLC4A_HUMAN, Q9UMR7
Function: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC)
differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory
motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation

Gene Wiki entry for CLEC4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC4A gene promoter:
         Nkx3-1 v4   AML1a   Pax-2   Nkx3-1 v1   Pax-2a   IRF-1   POU3F2   Nkx3-1 v2   Pax-2b   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC4A promoter sequence
   Search SABiosciences Chromatin IP Primers for CLEC4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

CLEC4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC4A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P008278:  view genomic region     (about GC identifiers)

Start:
8,276,228 bp from pter      End:
8,291,203 bp from pter
Size:
14,976 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLC4A_HUMAN, Q9UMR7 (See protein sequence)
Recommended Name: C-type lectin domain family 4 member A  
Size: 237 amino acids; 27512 Da
Subunit: May interact with PTPN6 via its ITIM motif
Subcellular location: Membrane; Single-pass type II membrane protein (Probable)
Sequence caution: Sequence=AAL56016.1; Type=Frameshift; Positions=229;
Secondary accessions: Q17R69 Q8WXW9 Q9H2Z9 Q9NS33 Q9UI34
Alternative splicing: 4 isoforms:  Q9UMR7-1   Q9UMR7-2   Q9UMR7-3   Q9UMR7-4   

Explore the universe of human proteins at neXtProt for CLEC4A: NX_Q9UMR7

Explore proteomics data for CLEC4A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UMR7

  • CLEC4A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLEC4A Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_057268.1  NP_919429.2  NP_919430.1  NP_919432.1  

    ENSEMBL proteins: 
     ENSP00000229332   ENSP00000344646   ENSP00000247243   ENSP00000353690   ENSP00000443082  

    Human Recombinant Protein Products for CLEC4A: 
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    Sino Biological Recombinant Protein for CLEC4A
    Sino Biological Cell Lysate for CLEC4A 
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    Cloud-Clone Corp. Proteins for CLEC4A 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS10438934

    CLEC4A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLEC: C-type lectin domain containing

    4 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q9UMR7

    ProtoNet protein and cluster: Q9UMR7

    1 Blocks protein domain: IPB002353 Type II antifreeze protein signature

    UniProtKB/Swiss-Prot: CLC4A_HUMAN, Q9UMR7
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind
    the SH2 domain of several SH2-containing phosphatases
    Similarity: Contains 1 C-type lectin domain


    CLEC4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLC4A_HUMAN, Q9UMR7
    Function: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC)
    differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory
    motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation
    Induction: Isoform 2 mRNA expression is up-regulated by agonists of neutrophils CSF2/GM-CSF, IL3/interleukin-3,
    IL4/interleukin-4 and IL13/interleukin-13

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS10438934
    GO:0030246carbohydrate binding IEA--
         
    CLEC4A for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Clec4a2):
     no phenotypic analysis 

    CLEC4A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Clec4a2tm1Psob for CLEC4A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLEC4A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC4A 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLEC4A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CLEC4A
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC4A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CLEC4A (Q9UMR73 ENSP000002293324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293503, ENSP000003915924I2D: score=1 STRING: ENSP00000391592
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS10438934
    GO:0007166cell surface receptor signaling pathway TAS10438934
    GO:0045087innate immune response IEA--

    CLEC4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLEC4A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLEC4A (CLC4A)

    1 HMDB Compound for CLEC4A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/24 Novoseek inferred chemical compound relationships for CLEC4A gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n,n-diacetylchitobiose 69.5 1 16116234 (1)
    mannose 61.6 6 18310920 (1), 12972549 (1), 10093645 (1), 12473263 (1) (see all 6)
    n-acetylglucosamine 56.8 4 8757624 (1), 9226570 (1), 18310920 (1), 8157977 (1)
    aminosugars 52.2 2 1470681 (1), 8082725 (1)
    galactose 50.8 3 18310920 (1), 2148949 (1), 8869505 (1)
    carbohydrates 47.1 7 1829437 (1), 1831224 (1), 9498072 (1), 8621059 (1) (see all 6)
    polysaccharide 45.3 9 19307599 (1), 9099704 (1), 10898932 (1), 8688417 (1) (see all 8)
    sodium periodate 44.8 2 9701801 (1), 1993708 (1)
    sialic acid 39.5 4 17981653 (1), 8168943 (1), 9701801 (1)
    superoxide 20.8 1 14967724 (1)

    Search CenterWatch for drugs/clinical trials and news about CLEC4A / CLC4A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLEC4A gene (4 alternative transcripts): 
    NM_016184.3  NM_194447.2  NM_194448.2  NM_194450.2  

    Unigene Cluster for CLEC4A:

    C-type lectin domain family 4, member A
    Hs.504657  [show with all ESTs]
    Unigene Representative Sequence: AF328684
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229332(uc001qtz.1 uc009zga.1 uc001qub.1 uc001quc.1 uc009zgb.1)
    ENST00000345999 ENST00000352620 ENST00000360500 ENST00000546339
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF067800.1 AF109146.1 AF200738.1 AF328684.1 AJ133532.1 BC074822.2 BC074874.2 BC117439.1 
    BC117441.1 EU196761.1 

    5 DOTS entries:

    DT.75100530  DT.100742380  DT.121173733  DT.91737632  DT.91737633 

    24/31 AceView cDNA sequences (see all 31):

    NM_016184 AA677149 BC074874 BC074822 NM_194447 NM_194450 NM_194448 BX106333 
    AA446401 AF200738 AF067800 AF328684 BQ002993 AI333747 AF109146 CD691817 
    AA380065 AJ133532 AI338670 AV711676 AI949910 AV716802 AA418441 AW242656 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                                                            
    SP2:                          -                                 
    SP3:                    -     -                                 


    ECgene alternative splicing isoforms for CLEC4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLEC4A expression in normal human tissues (normalized intensities)      CLEC4A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCTCTCTT
    CLEC4A Expression
    About this image


    CLEC4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Peripheral Blood Immature Myeloid Dendritic Cells   
             bone marrow-derived macrophages   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             Conventional Dendritic Cells II Spleen
             spleen ; cells in red pulp   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum

    See CLEC4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLEC4A

    SOURCE GeneReport for Unigene cluster: Hs.504657

    UniProtKB/Swiss-Prot: CLC4A_HUMAN, Q9UMR7
    Tissue specificity: Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF
    alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed
    preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate
    quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting
    cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by
    signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CLEC4A gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec4a21 , 5 C-type lectin domain family 4, member a21, 5 70.21(n)1
    54.89(a)1
      6 (58.18 cM)5
    268881  NM_011999.41  NP_036129.11 
     1231064285 


    ENSEMBL Gene Tree for CLEC4A (if available)
    TreeFam Gene Tree for CLEC4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLEC4A gene
    CD2072  CLEC17A2  CLEC4E2  ASGR22  CLEC4M2  CLEC4F2  CD2092  FCER22  
    CLEC10A2  CLEC6A2  ASGR12  CLEC4C2  CLEC4D2  CLEC4G2  
    5 SIMAP similar genes for CLEC4A using alignment to 2 protein entries:     CLC4A_HUMAN (see all proteins):
    CLEC4C    CLEC6A    CLEC4D    CLEC4E    CLEC10A

    CLEC4A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/306 SNPs in CLEC4A are shown (see all 306)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826118341,2
    --8274419(+) TGTATA/GAGGTT 4 -- us2k10--------
    rs1457293751,2
    --8274447(+) AGAGTA/CGCAAA 4 -- us2k10--------
    rs795703551,2
    C,F--8274448(+) GAGTCG/ACAAAT 4 -- us2k11Minor allele frequency- A:0.12WA 118
    rs1489311851,2
    --8274499(+) CAGCAC/TGTGGG 4 -- us2k10--------
    rs1437925981,2
    --8274650(+) TCCATA/GTGGTG 4 -- us2k10--------
    rs1477509221,2
    --8274658(+) GTGGGA/GTAGCC 4 -- us2k10--------
    rs19904761,2
    C,F,H--8274736(-) CTGACA/TCTCCA 4 -- us2k19Minor allele frequency- T:0.05MN NS EA NA WA 724
    rs768664161,2
    C,F--8274820(+) AGGAGG/ATGGTC 4 -- us2k11Minor allele frequency- A:0.03NA 120
    rs762156231,2
    C,F--8274844(+) AGCCCG/AGTGAG 4 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1425213281,2
    --8274889(+) ACCCAC/TAGGGT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLEC4A (8276228 - 8291203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CLEC4A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv428270CNV Gain18775914
    dgv459e1CNV Complex17122850
    dgv461e1CNV Complex17122850
    dgv455e1CNV Complex17122850
    dgv460e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605306    OMIM disorders: --

    20/22 diseases for CLEC4A (see all 22):    About MalaCards
    pneumonic plague    plague    pulmonary edema    vascular disease
    was-related disorders    osteoarthritis    eclampsia    pre-eclampsia
    atherosclerosis    acute myocardial infarction    hypercholesterolemia    coronary heart disease
    myocardial infarction    endotheliitis    rheumatoid arthritis    influenza
    pneumonia    arthritis    melanoma    inflammatory bowel disease

    1 disease from the University of Copenhagen DISEASES database for CLEC4A:
    Pneumonic plague

    CLEC4A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/12 Novoseek inferred disease relationships for CLEC4A gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 56.6 15 15727724 (2), 17022953 (1), 18000963 (1), 20033826 (1) (see all 13)
    atherosclerotic plaque 47 3 18092947 (1), 16146427 (1), 15961718 (1)
    cardiovascular diseases 21.9 2 20073134 (1), 14675775 (1)
    inflammation 20.6 4 11564777 (1), 11994513 (1), 18067591 (1), 19252093 (1)
    vascular diseases 14.4 1 20203069 (1)
    necrosis 13.3 6 18067591 (1), 8303299 (1), 8323280 (1), 10571070 (1) (see all 6)
    osteoarthritis 0.764 1 16945559 (1)
    rheumatoid arthritis 0 1 15529384 (1)
    tumors 0 7 8303299 (1), 8323280 (1), 10571070 (1), 1560214 (1) (see all 6)
    allergy 0 1 2054423 (1)


    Export disorders for CLEC4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLEC4A gene, integrated from 9 sources (see all 247):
    (articles sorted by number of sources associating them with CLEC4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. (PubMed id 10438934)1, 2, 3, 9 Bates E.E.M.... Saeland S. (1999)
    2. The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation. (PubMed id 11994513)1, 2, 9 Richard M.... Beaulieu A.D. (2002)
    3. Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants. (PubMed id 11178971)1, 2, 9 Huang X.... Cao X. (2001)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Association of arthritis with a gene complex encoding C-type lectin-like receptors. (PubMed id 17665455)1, 9 Lorentzen J.C....Fossum S. (2007)
    6. A replication study confirms the association of dendri tic cell immunoreceptor (DCIR) polymorphisms with ACPA - negative RA in a large Asian cohort. (PubMed id 22829930)1 Guo J....Li Z. (2012)
    7. Single nucleotide polymorphisms in C-type lectin genes , clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pat hogenesis of inflammatory bowel diseases. (PubMed id 22664939)1 Wolfkamp S.C....te Velde A.A. (2012)
    8. DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway. (PubMed id 21536857)1 Lambert A.A....Tremblay M.J. (2011)
    9. Cross-priming CD8+ T cells by targeting antigens to h uman dendritic cells through DCIR. (PubMed id 20530286)1 Klechevsky E....Banchereau J. (2010)
    10. DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production. (PubMed id 19028959)1 Meyer-Wentrup F....Adema G.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50856 HGNC: 13257 AceView: CLECSF6 Ensembl:ENSG00000111729 euGenes: HUgn50856
    ECgene: CLEC4A H-InvDB: CLEC4A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLEC4A Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00137

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLEC4A gene:
    Search GeneIP for patents involving CLEC4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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