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Aliases for CLEC3B Gene

Aliases for CLEC3B Gene

  • C-Type Lectin Domain Family 3 Member B 2 3 4 5
  • C-Type Lectin Domain Family 3, Member B 2 3
  • Plasminogen Kringle 4-Binding Protein 3 4
  • TNA 3 4
  • TN 3 4
  • Tetranectin (Plasminogen Binding Protein) 2
  • Tetranectin (Plasminogen-Binding Protein) 3

External Ids for CLEC3B Gene

Previous HGNC Symbols for CLEC3B Gene

  • TNA

Summaries for CLEC3B Gene

GeneCards Summary for CLEC3B Gene

CLEC3B (C-Type Lectin Domain Family 3 Member B) is a Protein Coding gene. Diseases associated with CLEC3B include byssinosis. Among its related pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is CLEC3A.

UniProtKB/Swiss-Prot for CLEC3B Gene

  • Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis.

Gene Wiki entry for CLEC3B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC3B Gene

Genomics for CLEC3B Gene

Regulatory Elements for CLEC3B Gene

Genomic Location for CLEC3B Gene

Chromosome:
3
Start:
45,001,548 bp from pter
End:
45,036,071 bp from pter
Size:
34,524 bases
Orientation:
Plus strand

Genomic View for CLEC3B Gene

Genes around CLEC3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC3B Gene

Proteins for CLEC3B Gene

  • Protein details for CLEC3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05452-TETN_HUMAN
    Recommended name:
    Tetranectin
    Protein Accession:
    P05452
    Secondary Accessions:
    • Q6FGX6

    Protein attributes for CLEC3B Gene

    Size:
    202 amino acids
    Molecular mass:
    22537 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for CLEC3B Gene

neXtProt entry for CLEC3B Gene

Proteomics data for CLEC3B Gene at MOPED

Post-translational modifications for CLEC3B Gene

Other Protein References for CLEC3B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CLEC3B (CLEC3B/Tetranectin)

No data available for DME Specific Peptides for CLEC3B Gene

Domains & Families for CLEC3B Gene

Gene Families for CLEC3B Gene

Protein Domains for CLEC3B Gene

Suggested Antigen Peptide Sequences for CLEC3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05452

UniProtKB/Swiss-Prot:

TETN_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC3B: view

Function for CLEC3B Gene

Molecular function for CLEC3B Gene

UniProtKB/Swiss-Prot Function:
Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis.
genes like me logo Genes that share phenotypes with CLEC3B: view

Animal Models for CLEC3B Gene

MGI Knock Outs for CLEC3B:

Animal Model Products

miRNA for CLEC3B Gene

miRTarBase miRNAs that target CLEC3B

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLEC3B Gene

Localization for CLEC3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC3B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC3B Gene COMPARTMENTS Subcellular localization image for CLEC3B gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CLEC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005737 cytoplasm IDA 7798325
genes like me logo Genes that share ontologies with CLEC3B: view

Pathways & Interactions for CLEC3B Gene

genes like me logo Genes that share pathways with CLEC3B: view

Interacting Proteins for CLEC3B Gene

Gene Ontology (GO) - Biological Process for CLEC3B Gene

None

No data available for SIGNOR curated interactions for CLEC3B Gene

Drugs & Compounds for CLEC3B Gene

(4) Drugs for CLEC3B Gene - From: Novoseek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tenecteplase Approved Pharma Target 39

(5) Additional Compounds for CLEC3B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLEC3B: view

Transcripts for CLEC3B Gene

Unigene Clusters for CLEC3B Gene

C-type lectin domain family 3, member B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC3B Gene

No ASD Table

Relevant External Links for CLEC3B Gene

GeneLoc Exon Structure for
CLEC3B
ECgene alternative splicing isoforms for
CLEC3B

Expression for CLEC3B Gene

mRNA expression in normal human tissues for CLEC3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC3B Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.8).

Protein differential expression in normal tissues from HIPED for CLEC3B Gene

This gene is overexpressed in Serum (15.9), Synovial fluid (14.0), Cerebrospinal fluid (8.1), Plasma (6.9), and Monocytes (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLEC3B Gene



SOURCE GeneReport for Unigene cluster for CLEC3B Gene Hs.476092

mRNA Expression by UniProt/SwissProt for CLEC3B Gene

P05452-TETN_HUMAN
Tissue specificity: Found in plasma.
genes like me logo Genes that share expression patterns with CLEC3B: view

Protein tissue co-expression partners for CLEC3B Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CLEC3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC3B 35
  • 99.5 (n)
  • 100 (a)
CLEC3B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLEC3B 36
  • 85 (a)
OneToOne
CLEC3B 35
  • 87.79 (n)
  • 85.15 (a)
dog
(Canis familiaris)
Mammalia CLEC3B 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec3b 16
Clec3b 35
  • 83.99 (n)
  • 79.21 (a)
Clec3b 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLEC3B 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLEC3B 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912012 35
  • 83.66 (n)
  • 80.2 (a)
chicken
(Gallus gallus)
Aves CLEC3B 35
  • 78.16 (n)
  • 75.29 (a)
CLEC3B 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLEC3B 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clec3b 35
  • 65.57 (n)
  • 59.56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6319 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01049058.1 36
  • 48 (a)
OneToMany
clec3ba 36
  • 53 (a)
OneToMany
LOC572488 35
  • 60.86 (n)
  • 58.43 (a)
Species with no ortholog for CLEC3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLEC3B Gene

ENSEMBL:
Gene Tree for CLEC3B (if available)
TreeFam:
Gene Tree for CLEC3B (if available)

Paralogs for CLEC3B Gene

Paralogs for CLEC3B Gene

(3) SIMAP similar genes for CLEC3B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLEC3B: view

Variants for CLEC3B Gene

Sequence variations from dbSNP and Humsavar for CLEC3B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_004189 -
VAR_004190 -
rs13963 - 45,035,631(+) CCCTG(A/G)GCACC reference, missense
rs8318 -- 45,035,966(+) GCAGG(A/G)GCCGC utr-variant-3-prime
rs939310 -- 45,034,440(+) ATGGA(C/T)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC3B Gene

Variant ID Type Subtype PubMed ID
nsv834676 CNV Gain+Loss 17160897
nsv508914 CNV Insertion 20534489
esv2725216 CNV Deletion 23290073
esv2343097 CNV Deletion 18987734
esv2725217 CNV Deletion 23290073

Variation tolerance for CLEC3B Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC3B Gene

HapMap Linkage Disequilibrium report
CLEC3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC3B Gene

Disorders for CLEC3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLEC3B Gene - From: DISEASES

Disorder Aliases PubMed IDs
byssinosis
  • cotton mill fever
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CLEC3B

Genetic Association Database (GAD)
CLEC3B
Human Genome Epidemiology (HuGE) Navigator
CLEC3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC3B
genes like me logo Genes that share disorders with CLEC3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLEC3B Gene

Publications for CLEC3B Gene

  1. Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer. (PMID: 1354271) Wewer U.M. … Albrechtsen R. (Lab. Invest. 1992) 3 4 23 67
  2. Tetranectin binds hepatocyte growth factor and tissue-type plasminogen activator. (PMID: 12694198) Westergaard U.B. … Petersen T.E. (Eur. J. Biochem. 2003) 3 23 25
  3. [Lipoprotein(a): a link between thrombogenesis and atherogenesis]. (PMID: 17853709) VuckoviA8 B. … DeriA8 M. (Med. Pregl. 2007) 23 25
  4. In the search of potential human islet stem cells: is tetranectin showing us the way? (PMID: 15848710) Hermann M. … Hengster P. (Transplant. Proc. 2005) 3 23
  5. Tetranectin in cerebrospinal fluid: biochemical characterisation and evidence of intrathecal synthesis or selective uptake into CSF. (PMID: 15901484) Stoevring B. … Christiansen M. (Clin. Chim. Acta 2005) 3 23

Products for CLEC3B Gene

Sources for CLEC3B Gene

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