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Aliases for CLEC3B Gene

Aliases for CLEC3B Gene

  • C-Type Lectin Domain Family 3, Member B 2 3
  • TNA 3 4 6
  • Tetranectin (Plasminogen Binding Protein) 2 3
  • Plasminogen Kringle 4-Binding Protein 3 4
  • TN 3 4
  • Tetranectin (Plasminogen-Binding Protein) 3
  • C-Type Lectin Domain Family 3 Member B 4
  • Tetranectin 3

External Ids for CLEC3B Gene

Previous Symbols for CLEC3B Gene

  • TNA

Summaries for CLEC3B Gene

GeneCards Summary for CLEC3B Gene

CLEC3B (C-Type Lectin Domain Family 3, Member B) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is CLEC3A.

UniProtKB/Swiss-Prot for CLEC3B Gene

  • Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis

Gene Wiki entry for CLEC3B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC3B Gene

Genomics for CLEC3B Gene

Genomic Location for CLEC3B Gene

Start:
45,001,548 bp from pter
End:
45,036,071 bp from pter
Size:
34,524 bases
Orientation:
Plus strand

Genomic View for CLEC3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC3B Gene

Regulatory Elements for CLEC3B Gene

Proteins for CLEC3B Gene

  • Protein details for CLEC3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05452-TETN_HUMAN
    Recommended name:
    Tetranectin
    Protein Accession:
    P05452
    Secondary Accessions:
    • Q6FGX6

    Protein attributes for CLEC3B Gene

    Size:
    202 amino acids
    Molecular mass:
    22537 Da
    Quaternary structure:
    • Homotrimer

    Three dimensional structures from OCA and Proteopedia for CLEC3B Gene

neXtProt entry for CLEC3B Gene

Proteomics data for CLEC3B Gene at MOPED

Post-translational modifications for CLEC3B Gene

Other Protein References for CLEC3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLEC3B Gene

Domains for CLEC3B Gene

Gene Families for CLEC3B Gene

HGNC:
  • CLEC :C-type lectin domain containing

Protein Domains for CLEC3B Gene

UniProtKB/Swiss-Prot:

TETN_HUMAN
Domain:
  • Contains 1 C-type lectin domain.:
    • P05452
genes like me logo Genes that share domains with CLEC3B: view

Function for CLEC3B Gene

Molecular function for CLEC3B Gene

UniProtKB/Swiss-Prot Function: Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis

Gene Ontology (GO) - Molecular Function for CLEC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 9786936
GO:0008201 heparin binding IDA 10727405
GO:0030246 carbohydrate binding IEA --
GO:0036143 kringle domain binding IPI 9786936
genes like me logo Genes that share ontologies with CLEC3B: view

Phenotypes for CLEC3B Gene

MGI mutant phenotypes for CLEC3B:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CLEC3B: view

Animal Models for CLEC3B Gene

MGI Knock Outs for CLEC3B:

miRNA for CLEC3B Gene

miRTarBase miRNAs that target CLEC3B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CLEC3B Gene

Localization for CLEC3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC3B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC3B Gene COMPARTMENTS Subcellular localization image for CLEC3B gene
Compartment Confidence
extracellular 5
nucleus 5
chloroplast 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CLEC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001652 granular component IDA 15848710
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space IDA 15901484
GO:0005737 cytoplasm IDA 15848710
GO:0031012 colocalizes_with extracellular matrix ISS 22261194
genes like me logo Genes that share ontologies with CLEC3B: view

Pathways for CLEC3B Gene

SuperPathways for CLEC3B Gene

No Data Available

Interacting Proteins for CLEC3B Gene

Gene Ontology (GO) - Biological Process for CLEC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0001503 ossification IEP 7798325
GO:0010756 positive regulation of plasminogen activation ISS --
GO:0030282 bone mineralization IEP 7589422
GO:0071310 cellular response to organic substance IEP 7589422
genes like me logo Genes that share ontologies with CLEC3B: view

No data available for Pathways by source for CLEC3B Gene

Compounds for CLEC3B Gene

(1) Drugbank Compounds for CLEC3B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Tenecteplase
  • t- PA
191588-94-0 target

(8) Novoseek inferred chemical compound relationships for CLEC3B Gene

Compound -log(P) Hits PubMed IDs
kininogen 41.4 1
percoll 28 1
fmlp 21.9 2
polysaccharide 14.2 2
heparin 8.53 6
genes like me logo Genes that share compounds with CLEC3B: view

Transcripts for CLEC3B Gene

mRNA/cDNA for CLEC3B Gene

Unigene Clusters for CLEC3B Gene

C-type lectin domain family 3, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC3B Gene

No ASD Table

Relevant External Links for CLEC3B Gene

GeneLoc Exon Structure for
CLEC3B
ECgene alternative splicing isoforms for
CLEC3B

Expression for CLEC3B Gene

mRNA expression in normal human tissues for CLEC3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC3B Gene

This gene is overexpressed in Adipose - Subcutaneous (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLEC3B Gene

SOURCE GeneReport for Unigene cluster for CLEC3B Gene Hs.476092

mRNA Expression by UniProt/SwissProt for CLEC3B Gene

P05452-TETN_HUMAN
Tissue specificity: Found in plasma
genes like me logo Genes that share expressions with CLEC3B: view

Orthologs for CLEC3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC3B 36
  • 99.5 (n)
  • 100 (a)
CLEC3B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLEC3B 36
  • 87.79 (n)
  • 85.15 (a)
CLEC3B 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC3B 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec3b 36
  • 83.99 (n)
  • 79.21 (a)
Clec3b 16
Clec3b 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLEC3B 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLEC3B 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912012 36
  • 83.66 (n)
  • 80.2 (a)
chicken
(Gallus gallus)
Aves CLEC3B 36
  • 78.16 (n)
  • 75.29 (a)
CLEC3B 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLEC3B 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clec3b 36
  • 65.57 (n)
  • 59.56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6319 36
zebrafish
(Danio rerio)
Actinopterygii CABZ01049058.1 37
  • 48 (a)
OneToMany
clec3ba 37
  • 53 (a)
OneToMany
LOC572488 36
  • 60.86 (n)
  • 58.43 (a)
Species with no ortholog for CLEC3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLEC3B Gene

ENSEMBL:
Gene Tree for CLEC3B (if available)
TreeFam:
Gene Tree for CLEC3B (if available)

Paralogs for CLEC3B Gene

Paralogs for CLEC3B Gene

Selected SIMAP similar genes for CLEC3B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLEC3B: view

Variants for CLEC3B Gene

Sequence variations from dbSNP and Humsavar for CLEC3B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8318 -- 45,035,966(+) GCAGG(A/G)GCCGC utr-variant-3-prime
rs13963 - 45,035,631(+) CCCTG(A/G)GCACC missense, reference
rs939309 -- 45,031,091(+) TCTCT(C/T)GGGGA intron-variant
rs939310 -- 45,034,440(+) ATGGA(C/T)AGAGG intron-variant
rs939311 -- 45,034,729(+) ACACC(G/T)CAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC3B Gene

Variant ID Type Subtype PubMed ID
nsv834676 CNV Gain+Loss 17160897
nsv508914 CNV Insertion 20534489
esv2725216 CNV Deletion 23290073
esv2343097 CNV Deletion 18987734
esv2725217 CNV Deletion 23290073

Relevant External Links for CLEC3B Gene

HapMap Linkage Disequilibrium report
CLEC3B

Disorders for CLEC3B Gene

(1) University of Copenhagen DISEASES for CLEC3B Gene

(15) Novoseek inferred disease relationships for CLEC3B Gene

Disease -log(P) Hits PubMed IDs
ovarian cancer 60.4 20
residual disease 23.5 4
ovarian carcinoma 23.5 3
breast carcinoma 21 4
tumors 17.1 31

Relevant External Links for CLEC3B

Genetic Association Database (GAD)
CLEC3B
Human Genome Epidemiology (HuGE) Navigator
CLEC3B
genes like me logo Genes that share disorders with CLEC3B: view

No data available for UniProtKB/Swiss-Prot for CLEC3B Gene

Publications for CLEC3B Gene

  1. The gene structure of tetranectin, a plasminogen binding protein. (PMID: 1511740) Berglund L. … Petersen T.E. (FEBS Lett. 1992) 3 4 23
  2. Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer. (PMID: 1354271) Wewer U.M. … Albrechtsen R. (Lab. Invest. 1992) 3 4 23
  3. Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil. (PMID: 9256258) Nielsen B.B. … Larsen I.K. (FEBS Lett. 1997) 3 4 23
  4. Structure of the C-type lectin carbohydrate recognition domain of human tetranectin. (PMID: 9757090) Kastrup J.S. … Larsen I.K. (Acta Crystallogr. D 1998) 3 4 23
  5. Mass spectrometric characterisation of post-translational modification and genetic variation in human tetranectin. (PMID: 10614823) Jaquinod M. … Roepstorff P. (Biol. Chem. 1999) 3 4 23

Products for CLEC3B Gene

Sources for CLEC3B Gene

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