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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC3B Gene

protein-coding   GIFtS: 56
GCID: GC03P045043

C-Type Lectin Domain Family 3, Member B

(Previous name: tetranectin (plasminogen binding protein))
(Previous symbol: TNA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 3, Member B1 2     TN2 3
TNA1 2 3 5     tetranectin2
Tetranectin (Plasminogen Binding Protein)1 2     Tetranectin (Plasminogen-Binding Protein)2
Plasminogen Kringle 4-Binding Protein2 3     C-Type Lectin Domain Family 3 Member B3

External Ids:    HGNC: 118911   Entrez Gene: 71232   Ensembl: ENSG000001638157   OMIM: 1875205   UniProtKB: P054523   

Export aliases for CLEC3B gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CLEC3B Gene: 
CLEC3B (C-type lectin domain family 3, member B) is a protein-coding gene. Diseases associated with CLEC3B include byssinosis, and silicosis. GO annotations related to this gene include heparin binding and calcium ion binding. An important paralog of this gene is CLEC3A.

UniProtKB/Swiss-Prot: TETN_HUMAN, P05452
Function: Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of
molecules destined for exocytosis

Gene Wiki entry for CLEC3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC3B gene promoter:
         AhR   AML1a   FOXO3   AP-4   Nkx2-5   Arnt   FOXO3b   PPAR-gamma1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC3B promoter sequence
   Search SABiosciences Chromatin IP Primers for CLEC3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22-p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p22-p21.3

CLEC3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC3B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P045043:  view genomic region     (about GC identifiers)

Start:
45,043,040 bp from pter      End:
45,077,563 bp from pter
Size:
34,524 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TETN_HUMAN, P05452 (See protein sequence)
Recommended Name: Tetranectin precursor  
Size: 202 amino acids; 22537 Da
Subunit: Homotrimer
Subcellular location: Secreted
Mass spectrometry: Mass=20535.8; Mass_error=2.4; Method=Electrospray; Range=22-202; Source=PubMed:10614823;
3 PDB 3D structures from and Proteopedia for CLEC3B:
1HTN (3D)        1RJH (3D)        1TN3 (3D)    
Secondary accessions: Q6FGX6

Explore the universe of human proteins at neXtProt for CLEC3B: NX_P05452

Explore proteomics data for CLEC3B at MOPED 

CLEC3B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CLEC3B Protein Expression

REFSEQ proteins: NP_003269.2  
ENSEMBL proteins: 
 ENSP00000296130   ENSP00000396013  

Human Recombinant Protein Products for CLEC3B: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CLEC3B (CLEC3B/Tetranectin)
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OriGene Purified Protein for CLEC3B
OriGene Protein Over-expression Lysate for CLEC3B
OriGene MassSpec for CLEC3B 
OriGene Custom Protein Services for CLEC3B
GenScript Custom Purified and Recombinant Proteins Services for CLEC3B
Novus Biologicals CLEC3B Protein
Novus Biologicals CLEC3B Lysates
Sino Biological Recombinant Protein for CLEC3B
Sino Biological Cell Lysate for CLEC3B 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for CLEC3B 

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001652granular component IDA15848710
GO:0005576extracellular region NAS14718574
GO:0005615extracellular space IDA15901484
GO:0005737cytoplasm IDA15848710
GO:0031012colocalizes with extracellular matrix ISS--

CLEC3B for ontologies           About GeneDecksing



CLEC3B Antibody Products: 
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Abcam antibodies for CLEC3B
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LSBio Antibodies in human, mouse, rat for CLEC3B 

Assay Products for CLEC3B: 
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GenScript Custom Assay Services for CLEC3B
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CLEC3B 
Cloud-Clone Corp. CLIAs for CLEC3B


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CLEC: C-type lectin domain containing

4 InterPro protein domains:
 IPR016187 C-type_lectin_fold
 IPR018378 C-type_lectin_CS
 IPR016186 C-type_lectin-like
 IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry P05452

ProtoNet protein and cluster: P05452

UniProtKB/Swiss-Prot: TETN_HUMAN, P05452
Similarity: Contains 1 C-type lectin domain


CLEC3B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TETN_HUMAN, P05452
Function: Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of
molecules destined for exocytosis

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005509calcium ion binding IDA9786936
GO:0008201heparin binding IDA10727405
GO:0030246carbohydrate binding IEA--
GO:0036143kringle domain binding IPI9786936
     
CLEC3B for ontologies           About GeneDecksing


Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Clec3b):
 skeleton 

CLEC3B for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Clec3btm1Umw for CLEC3B

   inGenious Targeting Laboratory - Custom generated mouse model solutions for CLEC3B 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLEC3B

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC3B 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLEC3B 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC3B
2 QIAGEN miScript miRNA Assays for microRNAs that regulate CLEC3B:
hsa-miR-518a-5p hsa-miR-450b-5p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
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Gene Editing
Products:
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Sirion Biotech Customized adenovirus for overexpression of CLEC3B

Clone
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GenScript: all cDNA clones in your preferred vector: CLEC3B (NM_003278)
Sino Biological Human cDNA Clone for CLEC3B
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC3B
Sirion Biotech Customized lentivirus for stable overexpression of CLEC3B 
                     Customized lentivirus expression plasmids for stable overexpression of CLEC3B 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC3B


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC3B

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/16 Interacting proteins for CLEC3B (P054522, 3 ENSP000002961304) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
InteractantInteraction Details
GeneCardExternal ID(s)
RPS6KB1P234432, 3, ENSP000002255774MINT-8269989 I2D: score=2 STRING: ENSP00000225577
ANXA7P200732, 3MINT-8248131 I2D: score=2 
CDKN1AP389362, 3MINT-8251692 I2D: score=2 
GADD45AP245222, 3MINT-8255742 I2D: score=2 
GSK3BP498412, 3MINT-8257031 I2D: score=2 
About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001501skeletal system development IEA--
GO:0001503ossification IEP7798325
GO:0010756positive regulation of plasminogen activation ISS--
GO:0030282bone mineralization IEP7589422
GO:0071310cellular response to organic substance IEP7589422

CLEC3B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CLEC3B for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLEC3B (TETN)

1 DrugBank Compound for CLEC3B    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Tenecteplaset- PA (see all 4)191588-94-0target--9034981 17853709 12694198

8 Novoseek inferred chemical compound relationships for CLEC3B gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
kininogen 41.4 1 10954207 (1)
percoll 28 1 2298916 (1)
fmlp 21.9 2 2298916 (1), 8418471 (1)
polysaccharide 14.2 2 10727405 (1), 1651300 (1)
heparin 8.53 6 10727405 (3), 11290444 (2), 1999192 (1)
oxygen 0 1 15174142 (1)
calcium 0 6 11290444 (2), 10964919 (1), 9757090 (1), 15222687 (1) (see all 5)
dexamethasone 0 3 7589422 (2)

Search CenterWatch for drugs/clinical trials and news about CLEC3B / TETN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLEC3B gene: 
NM_003278.2  

Unigene Cluster for CLEC3B:

C-type lectin domain family 3, member B
Hs.476092  [show with all ESTs]
Unigene Representative Sequence: CR749292
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000490386 ENST00000296130(uc003cok.4) ENST00000428034
miRNA
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2 QIAGEN miScript miRNA Assays for microRNAs that regulate CLEC3B:
hsa-miR-518a-5p hsa-miR-450b-5p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CLEC3B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC3B
Clone
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OriGene clones in human, mouse for CLEC3B (see all 7)
OriGene ORF clones in mouse, rat for CLEC3B
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GenScript: all cDNA clones in your preferred vector: CLEC3B (NM_003278)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC3B
Sirion Biotech Customized lentivirus for stable overexpression of CLEC3B 
                     Customized lentivirus expression plasmids for stable overexpression of CLEC3B 
Primer
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OriGene qPCR primer pairs and template standards for CLEC3B
OriGene qSTAR qPCR primer pairs in human, mouse for CLEC3B
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC3B
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC3B
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC3B

Additional mRNA sequence: 

AK312093.1 BC011024.1 CR541981.1 CR542009.1 CR749292.1 X64559.1 

4 DOTS entries:

DT.100816904  DT.312404  DT.100816902  DT.100816903 

24/349 AceView cDNA sequences (see all 349):

CA424555 BU527152 D29958 F35713 BM699038 BU542545 BQ013025 BQ017835 
BM931902 AA379211 BQ012642 AI083884 CR595857 CR601488 BI759141 BM789781 
CB163139 BM725615 AL559950 BQ931615 BM142017 BM678096 BU687816 BM676188 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLEC3B expression in normal human tissues (normalized intensities)      CLEC3B embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACCGGCGCCC
CLEC3B Expression
About this image


CLEC3B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/16 selected tissues (see all 16) fully expand
 
 Fibroblast
         X-gene Foreskin Fibroblasts   
 
 Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
         HyStem+BMP4-induced SM30 cells
         Normal Human Articular chondrocytes (NHAC)   
 
 Dermis (Uncategorized)    fully expand to see all 5 entries
         Human Dermal Fibroblasts-adult (HDF-a)   
 
 Bone (Muscoskeletal System)    fully expand to see all 4 entries
         HyStem+BMP4-induced SK11 cells
         Human Calvarial Osteoblasts (HCO)   
 
 Hair
         Human Hair Outer Root Sheath Cells (HHORSC)   

See CLEC3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLEC3B

SOURCE GeneReport for Unigene cluster: Hs.476092

UniProtKB/Swiss-Prot: TETN_HUMAN, P05452
Tissue specificity: Found in plasma

    SABiosciences Expression via Pathway-Focused PCR Array including CLEC3B: 
          Extracellular Matrix & Adhesion Molecules in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC3B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC3B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CLEC3B gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Clec3b1 , 5 C-type lectin domain family 3, member b1, 5 83.99(n)1
79.21(a)1
  9 (73.91 cM)5
219221  NM_011606.21  NP_035736.21 
 1231509465 
chicken
(Gallus gallus)
Aves CLEC3B1 C-type lectin domain family 3, member B 75.79(n)
69.65(a)
  395386  NM_204666.1  NP_989997.1 
lizard
(Anolis carolinensis)
Reptilia CLEC3B6
Uncharacterized protein
68(a)
1 ↔ 1
GL343611.1(320931-335142)
zebrafish
(Danio rerio)
Actinopterygii LOC5724881 tetranectin-like 59.6(n)
56.06(a)
  572488  XM_696211.3  XP_701303.3 


ENSEMBL Gene Tree for CLEC3B (if available)
TreeFam Gene Tree for CLEC3B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CLEC3B gene
CLEC3A2  CLEC11A2  
3 SIMAP similar genes for CLEC3B using alignment to 2 protein entries:     TETN_HUMAN (see all proteins):
DKFZp686H17246    CLEC3A    NCAN

CLEC3B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/264 SNPs in CLEC3B are shown (see all 264)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0041904
----see VAR_0041902 V M mis40--------
VAR_0041894
----see VAR_0041892 A S mis40--------
rs46830251,2
C,F--45065961(+) CTGCCC/GTGTGC 1 -- us2k19Minor allele frequency- G:0.41NA WA CSA EA 370
rs1384127101,2
--45066007(+) ACTGCA/GTCCTT 1 -- us2k10--------
rs1116089251,2
C,F--45066071(+) AGTCTC/TCTTCA 1 -- us2k12Minor allele frequency- T:0.03CSA WA 120
rs1437897801,2
--45066173(+) TGGCCA/GGAGTC 1 -- us2k10--------
rs1472487531,2
C--45066214(+) CCCCCC/GAGGTG 1 -- us2k10--------
rs1908609951,2
--45066232(+) CTTTTC/TATTGG 1 -- us2k10--------
rs1407545921,2
--45066246(+) TGTTGA/GTGTTT 1 -- us2k10--------
rs1809020591,2
--45066382(+) AACATC/TAGACT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CLEC3B (45043040 - 45077563 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for CLEC3B:    About this table     
Variant IDTypeSubtypePubMed ID
esv2343097CNV Deletion18987734
esv2725217CNV Deletion23290073
esv2725216CNV Deletion23290073
nsv508914CNV Insertion20534489
nsv834676CNV Gain+Loss17160897

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SeqTarget long-range PCR primers for resequencing CLEC3B
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 187520    OMIM disorders: --

20/36 diseases for CLEC3B (see all 36):    About MalaCards
byssinosis    silicosis    pelvic inflammatory disease    vesicoureteral reflux
gastric adenocarcinoma    endometrial adenocarcinoma    alcohol abuse    temporal lobe epilepsy
type 1 diabetes mellitus    cervical squamous cell carcinoma    cervical intraepithelial neoplasia    ovarian cancer
type 1 diabetes    multiple sclerosis    acute myocardial infarction    multiple myeloma
brain injury    chronic lymphocytic leukemia    rheumatoid arthritis    osteoarthritis

1 disease from the University of Copenhagen DISEASES database for CLEC3B:
Ovarian cancer

CLEC3B for disorders           About GeneDecksing

10/15 Novoseek inferred disease relationships for CLEC3B gene (see all 15)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cancer 60.4 28 8402458 (4), 12168866 (2), 8619942 (2), 9760017 (2) (see all 14)
residual disease 23.5 4 8619942 (2), 9868384 (1), 20121334 (1)
ovarian carcinoma 23.5 3 7998355 (2), 17013795 (1)
breast carcinoma 21 5 15047748 (2), 7998355 (1), 1651300 (1)
tumors 17.1 46 7868087 (3), 17013795 (3), 9868384 (3), 7781862 (3) (see all 18)
breast cancer metastatic 15.4 1 9868384 (1)
carcinoma 9.69 7 7868087 (1), 8402458 (1), 7998355 (1), 11962752 (1) (see all 5)
cancer 9.43 17 8402458 (2), 7998355 (2), 9868384 (2), 2301372 (1) (see all 10)
neurological disorders 0 6 17101549 (3), 15901484 (1)
breast cancer 0 4 15047748 (2), 1576006 (2)

Genetic Association Database (GAD): CLEC3B
Human Genome Epidemiology (HuGE) Navigator: CLEC3B (1 document)

Export disorders for CLEC3B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CLEC3B gene, integrated from 9 sources (see all 113):
(articles sorted by number of sources associating them with CLEC3B)
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  1. Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer. (PubMed id 1354271)1, 2, 9 Wewer U.M. and Albrechtsen R. (1992)
  2. Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil. (PubMed id 9256258)1, 2, 9 Nielsen B.B.... Larsen I.K. (1997)
  3. Structure of the C-type lectin carbohydrate recognition domain of human tetranectin. (PubMed id 9757090)1, 2, 9 Kastrup J.S.... Larsen I.K. (1998)
  4. Mass spectrometric characterisation of post-translational modification and genetic variation in human tetranectin. (PubMed id 10614823)1, 2, 9 Jaquinod M....Roepstorff P. (1999)
  5. The gene structure of tetranectin, a plasminogen binding protein. (PubMed id 1511740)1, 2, 9 Berglund L. and Petersen T.E. (1992)
  6. Tetranectin binds hepatocyte growth factor and tissue-type plasminogen activator. (PubMed id 12694198)1, 7, 9 Westergaard U.B....Petersen T.E. (2003)
  7. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. (PubMed id 16453284)1, 4 Valdes A.M....Spector T.D. (2006)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  9. Primary structure of tetranectin, a plasminogen kringle 4 binding plasma protein: homology with asialoglycoprotein receptors and cartilage proteoglycan core protein. (PubMed id 3427041)1, 2 Fuhlendorff J.... Magnusson S. (1987)
  10. Tetranectin in cerebrospinal fluid: biochemical characterisation and evidence of intrathecal synthesis or selective uptake into CSF. (PubMed id 15901484)1, 9 Stoevring B....Christiansen M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7123 HGNC: 11891 AceView: TNAandEXOSC7 Ensembl:ENSG00000163815 euGenes: HUgn7123
ECgene: CLEC3B H-InvDB: CLEC3B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CLEC3B Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_260

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CLEC3B gene:
Search GeneIP for patents involving CLEC3B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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