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Aliases for CLEC3A Gene

Aliases for CLEC3A Gene

  • C-Type Lectin Domain Family 3, Member A 2 3
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 1 (Cartilage-Derived) 2 3
  • CLECSF1 3 4
  • C-Type Lectin Domain Family 3 Member A 3
  • C-Type Lectin Superfamily Member 1 4
  • Cartilage-Derived C-Type Lectin 4

External Ids for CLEC3A Gene

Previous Symbols for CLEC3A Gene


Summaries for CLEC3A Gene

GeneCards Summary for CLEC3A Gene

CLEC3A (C-Type Lectin Domain Family 3, Member A) is a Protein Coding gene. Diseases associated with CLEC3A include methylmalonic acidemia. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC11A.

UniProtKB/Swiss-Prot for CLEC3A Gene

  • Promotes cell adhesion to laminin-332 and fibronectin

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC3A Gene

Genomics for CLEC3A Gene

Genomic Location for CLEC3A Gene

78,022,515 bp from pter
78,066,761 bp from pter
44,247 bases
Plus strand

Genomic View for CLEC3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC3A Gene

Proteins for CLEC3A Gene

  • Protein details for CLEC3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 3 member A
    Protein Accession:
    Secondary Accessions:
    • B2R8C4
    • Q3SX91
    • Q6UXF5

    Protein attributes for CLEC3A Gene

    197 amino acids
    Molecular mass:
    22233 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ88742.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for CLEC3A Gene

Proteomics data for CLEC3A Gene at MOPED

Post-translational modifications for CLEC3A Gene

No Post-translational modifications

Other Protein References for CLEC3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLEC3A Gene

Domains for CLEC3A Gene

Gene Families for CLEC3A Gene

  • CLEC :C-type lectin domain containing

Protein Domains for CLEC3A Gene

Suggested Antigen Peptide Sequences for CLEC3A Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.:
    • O75596
genes like me logo Genes that share domains with CLEC3A: view

Function for CLEC3A Gene

Molecular function for CLEC3A Gene

UniProtKB/Swiss-Prot Function: Promotes cell adhesion to laminin-332 and fibronectin

Gene Ontology (GO) - Molecular Function for CLEC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC3A: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLEC3A Gene

Localization for CLEC3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC3A Gene


Subcellular locations from

Jensen Localization Image for CLEC3A Gene COMPARTMENTS Subcellular localization image for CLEC3A gene
Compartment Confidence
extracellular 5
chloroplast 2
mitochondrion 2
nucleus 2
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CLEC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CLEC3A: view

Pathways for CLEC3A Gene

SuperPathways for CLEC3A Gene

No Data Available

Interacting Proteins for CLEC3A Gene

Gene Ontology (GO) - Biological Process for CLEC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 10524194
genes like me logo Genes that share ontologies with CLEC3A: view

No data available for Pathways by source for CLEC3A Gene

Transcripts for CLEC3A Gene

mRNA/cDNA for CLEC3A Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC3A Gene

C-type lectin domain family 3, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC3A Gene

No ASD Table

Relevant External Links for CLEC3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC3A Gene

mRNA expression in normal human tissues for CLEC3A Gene

mRNA differential expression in normal tissues according to GTEx for CLEC3A Gene

This gene is overexpressed in Bladder (23.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CLEC3A Gene

SOURCE GeneReport for Unigene cluster for CLEC3A Gene Hs.177936

mRNA Expression by UniProt/SwissProt for CLEC3A Gene

Tissue specificity: Restricted to cartilage and breast. Also expressed in breast cancers.
genes like me logo Genes that share expressions with CLEC3A: view

Orthologs for CLEC3A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC3A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLEC3A 35
  • 99.32 (n)
  • 99.49 (a)
  • 99 (a)
(Bos Taurus)
Mammalia CLEC3A 35
  • 89.51 (n)
  • 87.43 (a)
  • 88 (a)
(Canis familiaris)
Mammalia CLEC3A 35
  • 91.16 (n)
  • 90.31 (a)
  • 90 (a)
(Mus musculus)
Mammalia Clec3a 35
  • 86.05 (n)
  • 87.24 (a)
Clec3a 16
Clec3a 36
  • 87 (a)
(Monodelphis domestica)
Mammalia CLEC3A 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia CLEC3A 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Clec3a 35
  • 87.41 (n)
  • 86.73 (a)
(Gallus gallus)
Aves CLEC3A 35
  • 74.27 (n)
  • 75.65 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia CLEC3A 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia clec3a 35
  • 69.43 (n)
  • 68.39 (a)
(Danio rerio)
Actinopterygii CLEC3A 36
  • 57 (a)
LOC100330122 35
  • 62.15 (n)
  • 57.81 (a)
Species with no ortholog for CLEC3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLEC3A Gene

Gene Tree for CLEC3A (if available)
Gene Tree for CLEC3A (if available)

Paralogs for CLEC3A Gene

Paralogs for CLEC3A Gene

Selected SIMAP similar genes for CLEC3A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CLEC3A: view

Variants for CLEC3A Gene

Sequence variations from dbSNP and Humsavar for CLEC3A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1114817 -- 78,026,812(+) ACAGC(C/T)ATAAA intron-variant
rs1546820 -- 78,026,298(+) GAATT(A/T)TAGAC intron-variant
rs1546821 -- 78,026,326(+) TACAG(A/C)ACACA intron-variant
rs1922608 -- 78,031,242(+) AACAA(A/G)AATTC utr-variant-3-prime
rs1922609 -- 78,031,492(+) TGAAA(G/T)GAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CLEC3A Gene

Variant ID Type Subtype PubMed ID
nsv906962 CNV Gain 21882294
dgv2919n71 CNV Gain 21882294
nsv833293 CNV Gain 17160897
nsv817742 CNV Gain 17921354
dgv2920n71 CNV Loss 21882294

Relevant External Links for CLEC3A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC3A Gene

Disorders for CLEC3A Gene

(1) MalaCards Diseases for CLEC3A Gene

Search for CLEC3A Gene in MalaCards »

(1) University of Copenhagen DISEASES for CLEC3A Gene

Relevant External Links for CLEC3A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CLEC3A: view

No data available for UniProtKB/Swiss-Prot for CLEC3A Gene

Publications for CLEC3A Gene

  1. The cartilage-derived, C-type lectin (CLECSF1): structure of the gene and chromosomal location. (PMID: 10524194) Neame P.J. … Grimm D.R. (Biochim. Biophys. Acta 1999) 2 3 4 23
  2. Matrilysin (MMP-7) cleaves C-type lectin domain family 3 member A (CLEC3A) on tumor cell surface and modulates its cell adhesion activity. (PMID: 19173304) Tsunezumi J. … Miyazaki K. (J. Cell. Biochem. 2009) 3 4 23
  3. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 48
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CLEC3A Gene

Sources for CLEC3A Gene

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