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Aliases for CLEC2L Gene

Aliases for CLEC2L Gene

  • C-Type Lectin Domain Family 2 Member L 2 3 5
  • C-Type Lectin Domain Family 2, Member L 2

External Ids for CLEC2L Gene

Previous GeneCards Identifiers for CLEC2L Gene

  • GC07P138677
  • GC07P138872
  • GC07P139208
  • GC07P133519

Summaries for CLEC2L Gene

GeneCards Summary for CLEC2L Gene

CLEC2L (C-Type Lectin Domain Family 2 Member L) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD69.

Additional gene information for CLEC2L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC2L Gene

Genomics for CLEC2L Gene

Regulatory Elements for CLEC2L Gene

Enhancers for CLEC2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H139679 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +158.2 158157 5 ATF1 MLX ZFP64 SIN3A YY1 FOS ATF7 RUNX3 SP5 REST TBXAS1 HIPK2 ERHP1 CLEC2L KDM7A PIR36040 LOC105375530
GH07H139588 0.9 ENCODE dbSUPER 11.3 +64.9 64933 1 SOX6 CEBPB CEBPG ZEB2 ZFHX2 ZNF766 RUNX1 KLF16 FOXK2 POLR2A ERHP1 CLEC2L KDM7A LOC105375530 PIR36040
GH07H139613 0.6 ENCODE dbSUPER 10.7 +90.3 90270 1 MAFK HIPK2 TBXAS1 ERHP1 CLEC2L LOC105375530 PIR36040
GH07H139609 0.5 dbSUPER 10.9 +86.6 86628 1 NRF1 NR2C1 NR2C2 ERHP1 CLEC2L LOC105375530 PIR36040
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLEC2L on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC2L Gene

139,523,856 bp from pter
139,544,985 bp from pter
21,130 bases
Plus strand

Genomic View for CLEC2L Gene

Genes around CLEC2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC2L Gene

Proteins for CLEC2L Gene

  • Protein details for CLEC2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 2 member L
    Protein Accession:

    Protein attributes for CLEC2L Gene

    214 amino acids
    Molecular mass:
    23927 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC2L Gene

Post-translational modifications for CLEC2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLEC2L Gene

No data available for DME Specific Peptides for CLEC2L Gene

Domains & Families for CLEC2L Gene

Gene Families for CLEC2L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CLEC2L Gene

Suggested Antigen Peptide Sequences for CLEC2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLEC2L: view

No data available for UniProtKB/Swiss-Prot for CLEC2L Gene

Function for CLEC2L Gene

Gene Ontology (GO) - Molecular Function for CLEC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC2L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CLEC2L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC2L Gene

Localization for CLEC2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC2L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC2L gene
Compartment Confidence
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CLEC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC2L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC2L Gene

Pathways & Interactions for CLEC2L Gene

SuperPathways for CLEC2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLEC2L Gene


No data available for Pathways by source and SIGNOR curated interactions for CLEC2L Gene

Drugs & Compounds for CLEC2L Gene

No Compound Related Data Available

Transcripts for CLEC2L Gene

mRNA/cDNA for CLEC2L Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC2L Gene

C-type lectin domain family 2, member L:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CLEC2L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC2L Gene

No ASD Table

Relevant External Links for CLEC2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLEC2L Gene

mRNA differential expression in normal tissues according to GTEx for CLEC2L Gene

This gene is overexpressed in Brain - Cortex (x8.3), Brain - Anterior cingulate cortex (BA24) (x7.4), Brain - Frontal Cortex (BA9) (x7.2), Brain - Cerebellum (x4.3), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for CLEC2L Gene

This gene is overexpressed in Frontal cortex (53.9) and Platelet (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLEC2L Gene

Protein tissue co-expression partners for CLEC2L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLEC2L Gene:


SOURCE GeneReport for Unigene cluster for CLEC2L Gene:

genes like me logo Genes that share expression patterns with CLEC2L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC2L Gene

Orthologs for CLEC2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC2L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLEC2L 33 34
  • 100 (n)
(Bos Taurus)
Mammalia CLEC2L 34
  • 92 (a)
LOC781590 33
  • 90.74 (n)
(Rattus norvegicus)
Mammalia Clec2l 33
  • 89.81 (n)
(Mus musculus)
Mammalia Clec2l 33 16 34
  • 89.26 (n)
(Monodelphis domestica)
Mammalia CLEC2L 34
  • 83 (a)
(Canis familiaris)
Mammalia CLEC2L 33 34
  • 82.72 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 27 (a)
-- 34
  • 27 (a)
(Gallus gallus)
Aves -- 34
  • 24 (a)
Species where no ortholog for CLEC2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC2L Gene

Gene Tree for CLEC2L (if available)
Gene Tree for CLEC2L (if available)

Paralogs for CLEC2L Gene

Paralogs for CLEC2L Gene

(13) SIMAP similar genes for CLEC2L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLEC2L: view

Variants for CLEC2L Gene

Sequence variations from dbSNP and Humsavar for CLEC2L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000064568 -- 139,523,041(+) CAGGC(A/G)ACGCG upstream-variant-2KB
rs1000073088 -- 139,522,561(+) GGCGT(A/G)GTGGC upstream-variant-2KB
rs1000136562 -- 139,526,453(+) CCAGG(G/T)TGCTG intron-variant
rs1000222076 -- 139,538,873(+) ACTAG(G/T)TTGGG intron-variant
rs1000346718 -- 139,529,134(+) CAGTC(C/T)TTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC2L Gene

Variant ID Type Subtype PubMed ID
esv24293 CNV gain 19812545
esv2735212 CNV deletion 23290073
esv3615215 CNV gain 21293372
esv3615216 CNV gain 21293372
nsv1119140 CNV deletion 24896259

Variation tolerance for CLEC2L Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC2L Gene

Disorders for CLEC2L Gene

Relevant External Links for CLEC2L

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLEC2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC2L Gene

Publications for CLEC2L Gene

  1. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing RM … Figeys D (Molecular systems biology 2007) 3 60
  2. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. (PMID: 17463248) Scott LJ … Boehnke M (Science (New York, N.Y.) 2007) 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4 60
  5. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 60

Products for CLEC2L Gene

Sources for CLEC2L Gene

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