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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC2L Gene

protein-coding   GIFtS: 40
GCID: GC07P139208          (predicted)

C-Type Lectin Domain Family 2, Member L

  Search for CLEC2L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 2, Member L1 2
C-Type Lectin Domain Family 2 Member L2

External Ids:    HGNC: 219691   Entrez Gene: 1547902   Ensembl: ENSG000002362797   UniProtKB: P0C7M83   

Export aliases for CLEC2L gene to outside databases

Previous GC identifers: GC07P138677 GC07P138872 GC07P133519


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CLEC2L Gene: 
CLEC2L (C-type lectin domain family 2, member L) is a protein-coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC2D.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC2L gene promoter:
         AP-1   AML1a   p300   LCR-F1   C/EBPalpha   CHOP-10   MEF-2A   POU2F1   POU2F1a   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CLEC2L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

CLEC2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC2L gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P139208:  view genomic region     (about GC identifiers)

Start:
139,208,602 bp from pter      End:
139,229,731 bp from pter
Size:
21,130 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 138,553,223-138,574,276     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLC2L_HUMAN, P0C7M8 (See protein sequence)
Recommended Name: C-type lectin domain family 2 member L  
Size: 214 amino acids; 23927 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for CLEC2L: NX_P0C7M8

Explore proteomics data for CLEC2L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0C7M8

  • CLEC2L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLEC2L Protein Expression
    REFSEQ proteins: NP_001073980.2  
    ENSEMBL proteins: 
     ENSP00000390661   ENSP00000428508  

    Human Recombinant Protein Products for CLEC2L: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    CLEC2L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P0C7M8

    ProtoNet protein and cluster: P0C7M8

    UniProtKB/Swiss-Prot: CLC2L_HUMAN, P0C7M8
    Similarity: Contains 1 C-type lectin domain


    CLEC2L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding IEA--
         
    CLEC2L for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC2L

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CLEC2L (P0C7M83 ENSP000003906614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FIBPO434273, ENSP000003445724I2D: score=1 STRING: ENSP00000344572
    EXT2Q930633, ENSP000003426564I2D: score=1 STRING: ENSP00000342656
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLEC2L (CLC2L)

    Search CenterWatch for drugs/clinical trials and news about CLEC2L / CLC2L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLEC2L gene: 
    NM_001080511.2  

    Unigene Cluster for CLEC2L:

    C-type lectin domain family 2, member L
    Hs.57806  [show with all ESTs]
    Unigene Representative Sequence: AK057548
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422142(uc010lnd.3) ENST00000521281 ENST00000520413
    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CLEC2L (see all 10):
    hsa-miR-3184 hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-3914 hsa-miR-423-5p hsa-miR-873 hsa-miR-214
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLEC2L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC2L
    Clone
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    OriGene ORF clones in mouse, rat for CLEC2L
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLEC2L
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC2L
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    Additional mRNA sequence: AK057548.1 

    2 DOTS entries:

    DT.106974  DT.92039149 

    13 AceView cDNA sequences:

    AK057548 BV196207 AA325781 BU633379 BF945734 AA041192 AA041430 AI499740 
    BF792388 AI085797 AA985339 BQ184955 AA865558 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLEC2L expression in normal human tissues (normalized intensities)      CLEC2L embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAGGTACA
    CLEC2L Expression
    About this image


    CLEC2L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...

    See CLEC2L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLEC2L

    SOURCE GeneReport for Unigene cluster: Hs.57806
        SABiosciences Custom PCR Arrays for CLEC2L
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC2L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC2L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC2L gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec2l1 , 5 C-type lectin domain family, member L1, 5 87.99(n)1
    95.26(a)1
      6 (17.85 cM)5
    6651801  NM_001101507.11  NP_001094977.11 
     386630695 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    15(a)
    possible ortholog
    2(102885527-102899931)
    zebrafish
    (Danio rerio)
    Actinopterygii --
    --
    15(a)
    possible ortholog
    16(14031039-14044474)


    ENSEMBL Gene Tree for CLEC2L (if available)
    TreeFam Gene Tree for CLEC2L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLEC2L gene
    CLEC2D2  CLEC2A2  CLEC2B2  CD692  
    13 SIMAP similar genes for CLEC2L using alignment to 2 protein entries:     CLC2L_HUMAN (see all proteins):
    CLEC2D    KLRG1    CD69    FCER2    KLRC1    KLRC2
    CLEC2B    ASGR1    CLEC10A    OLR1    CLEC1B    CLEC2A
    CLEC4C

    CLEC2L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/500 SNPs in CLEC2L are shown (see all 500)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1136754591,2
    F--139206689(+) AATCAG/CAAGCA 1 -- us2k13Minor allele frequency- C:0.05CSA WA 122
    rs1881008811,2
    --139206728(+) GTGCAC/TGGGGG 1 -- us2k10--------
    rs1920332501,2
    --139206767(+) AGGAGA/GTGTGT 1 -- us2k10--------
    rs591382011,2
    C,F--139206773(+) TGTGTT/CCCAGG 1 -- us2k16Minor allele frequency- C:0.21WA CSA NA 244
    rs1432333301,2
    --139206887(+) GAGCAA/GGACTT 1 -- us2k10--------
    rs1164324481,2
    C,F--139206912(+) CTTGAG/AGCCTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs587923061,2
    C,F--139207132(+) CAATGC/GGCAGA 1 -- us2k15Minor allele frequency- G:0.27WA CSA NA 242
    rs1829434781,2
    --139207207(+) GGGAGG/TCCGAG 1 -- us2k10--------
    rs1876396461,2
    --139207232(+) AGGTCA/GGGAGA 1 -- us2k10--------
    rs1925121921,2
    --139207515(+) GGAGAC/TCCAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLEC2L (139208602 - 139229731 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CLEC2L:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2735212CNV Deletion23290073
    esv24293CNV Gain19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CLEC2L for disorders           About MalaCards

    CLEC2L for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLEC2L

    Export disorders for CLEC2L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLEC2L gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CLEC2L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. (PubMed id 17463248)4 Scott L.J....Boehnke M. (2007)
    2. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    5. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 154790 HGNC: 21969 AceView: LOC154790 Ensembl:ENSG00000236279 euGenes: HUgn154790
    ECgene: CLEC2L H-InvDB: CLEC2L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLEC2L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLEC2L gene:
    Search GeneIP for patents involving CLEC2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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