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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC2L Gene

protein-coding   GIFtS: 40
GCID: GC07P139208          (predicted)

C-type lectin domain family 2, member L
  Search for CLEC2L
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLEC2L    

Aliases
for CLEC2L gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
C-Type Lectin Domain Family 2, Member L1 2
FLJ329861
C-Type Lectin Domain Family 2 Member L2

External Ids:    HGNC: 219691   Entrez Gene: 1547902   Ensembl: ENSG000002362797   UniProtKB: P0C7M83   

Export aliases for CLEC2L gene to outside databases

Previous GC identifers: GC07P138677 GC07P138872 GC07P133519


Summaries
for CLEC2L gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for CLEC2L gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC2L gene promoter:
         AP-1   AML1a   p300   LCR-F1   C/EBPalpha   CHOP-10   MEF-2A   POU2F1   POU2F1a   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CLEC2L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

CLEC2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC2L gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P139208:  view genomic region     (about GC identifiers)

Start:
 139,208,602 bp from pter      End:
 139,229,731 bp from pter
Size:
 21,130 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 138,553,223-138,574,276     

Proteins
for CLEC2L gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLC2L_HUMAN, P0C7M8 (See protein sequence)
Recommended Name: C-type lectin domain family 2 member L  
Size: 214 amino acids; 23927 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for CLEC2L: NX_P0C7M8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P0C7M8

    • CLEC2L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001073980.2  
    ENSEMBL proteins: 
     ENSP00000390661   ENSP00000428508  

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    Uscn Proteins for CLEC2L

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    CLEC2L for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CLEC2L gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLEC2L for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P0C7M8

    ProtoNet protein and cluster: P0C7M8

    UniProtKB/Swiss-Prot: CLC2L_HUMAN, P0C7M8
    Similarity: Contains 1 C-type lectin domain


    Function
    for CLEC2L gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Inhib. RNA
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding IEA--


    CLEC2L for ontologies           About GeneDecksing



    Pathways & Interactions
    for CLEC2L gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC2L

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CLEC2L (P0C7M83 ENSP000003906614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FIBPO434273, ENSP000003445724I2D: score=1 STRING: ENSP00000344572
    EXT2Q930633, ENSP000003426564I2D: score=1 STRING: ENSP00000342656
    About this table

    Drugs & Compounds
    for CLEC2L gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CLEC2L
    Search CenterWatch for drugs/clinical trials and news about CLEC2L / CLC2L 

    Transcripts
    for CLEC2L gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for CLEC2L gene: 
    NM_001080511.2  

    Unigene Cluster for CLEC2L:

    C-type lectin domain family 2, member L
    Hs.57806  [show with all ESTs]
    Unigene Representative Sequence: AK057548
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422142(uc010lnd.3) ENST00000521281 ENST00000520413

    miRNA
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    hsa-miR-3184 hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-3914 hsa-miR-423-5p hsa-miR-873 hsa-miR-214
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC2L (see all 7)
    OriGene shRNA RFP: CLEC2L
    OriGene siRNA: CLEC2L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC2L
    Clone
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    Primer
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    Additional cDNA sequence: AK057548.1 

    2 DOTS entries:

    DT.106974  DT.92039149 

    13 AceView cDNA sequences:

    AK057548 BU633379 AA325781 BV196207 AA985339 AA041430 AI085797 BF792388 
    BQ184955 BF945734 AI499740 AA041192 AA865558 

    GeneLoc Exon Structure


    Expression
    for CLEC2L gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLEC2L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATAGGTACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLEC2L expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CLEC2L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLEC2L

    SOURCE GeneReport for Unigene cluster: Hs.57806
        SABiosciences Custom PCR Arrays for CLEC2L
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC2L

    Orthologs
    for CLEC2L gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for CLEC2L (if available)
    TreeFam Gene Tree for CLEC2L (if available) 

    Paralogs
    for CLEC2L gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLEC2L gene
    CLEC2A2  CLEC2B2  KLRF22  KLRG22  CD692  CLEC2D2  CLEC5A2  KLRF12  
    KLRG12  KLRB12  
    14 SIMAP similar genes for CLEC2L using alignment to 2 protein entries:     CLC2L_HUMAN (see all proteins):
    CLEC2D    KLRG1    CD69    FCER2    KLRC1    KLRC2
    CLEC2B    ASGR1    CLEC10A    OLR1    CLEC1B    CLEC2A
    CLEC4C    KLRD1

    CLEC2L for paralogs           About GeneDecksing



    Genomic Variants
    for CLEC2L gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/421 NCBI SNPs in CLEC2L are shown (see all 421)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1136754591,2
    		F,--139206689(+) AATCAG/CAAGCA 1 -- us2k13Minor allele frequency- C:0.05CSA WA 122
    rs1881008811,2
    		--139206728(+) GTGCAC/TGGGGG 1 -- us2k10--------
    rs1920332501,2
    		--139206767(+) AGGAGA/GTGTGT 1 -- us2k10--------
    rs591382011,2
    		C,F,--139206773(+) TGTGTT/CCCAGG 1 -- us2k16Minor allele frequency- C:0.21WA CSA NA 244
    rs1432333301,2
    		--139206887(+) GAGCAA/GGACTT 1 -- us2k10--------
    rs1164324481,2
    		F,--139206912(+) CTTGAG/AGCCTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs587923061,2
    		C,--139207132(+) CAATGC/GGCAGA 1 -- us2k15Minor allele frequency- G:0.27WA CSA NA 242
    rs1829434781,2
    		--139207207(+) GGGAGG/TCCGAG 1 -- us2k10--------
    rs1876396461,2
    		--139207232(+) AGGTCA/GGGAGA 1 -- us2k10--------
    rs1925121921,2
    		--139207515(+) GGAGAC/TCCAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLEC2L (139208602 - 139229731 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CLEC2L
         1 CNV: 70046

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    Disorders / Diseases
    for CLEC2L gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for CLEC2L gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLEC2L gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CLEC2L)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    4. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    External Searches for CLEC2L gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CLEC2L gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 154790 HGNC: 21969 AceView: LOC154790 Ensembl:ENSG00000236279 euGenes: HUgn154790
    ECgene: CLEC2L H-InvDB: CLEC2L

    Other Databases showing CLEC2L gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLEC2L gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLEC2L Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLEC2L gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLEC2L gene:
    Search GeneIP for patents involving CLEC2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CLEC2L gene

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    About This Section

     
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