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CLEC2L Gene

protein-coding   GIFtS: 41
GCID: GC07P139208          (predicted)

C-Type Lectin Domain Family 2, Member L

  Search for CLEC2L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C-Type Lectin Domain Family 2, Member L1 2
C-Type Lectin Domain Family 2 Member L2

External Ids:    HGNC: 219691   Entrez Gene: 1547902   Ensembl: ENSG000002362797   UniProtKB: P0C7M83   

Export aliases for CLEC2L gene to outside databases

Previous GC identifers: GC07P138677 GC07P138872 GC07P133519


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CLEC2L Gene:
CLEC2L (C-type lectin domain family 2, member L) is a protein-coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC2D.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLEC2L gene promoter:
         AP-1   AML1a   p300   LCR-F1   C/EBPalpha   CHOP-10   MEF-2A   POU2F1   POU2F1a   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CLEC2L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

CLEC2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC2L gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P139208:  view genomic region     (about GC identifiers)

Start:
139,208,602 bp from pter      End:
139,229,731 bp from pter
Size:
21,130 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 138,553,223-138,574,276     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLC2L_HUMAN, P0C7M8 (See protein sequence)
Recommended Name: C-type lectin domain family 2 member L  
Size: 214 amino acids; 23927 Da

Explore the universe of human proteins at neXtProt for CLEC2L: NX_P0C7M8

Explore proteomics data for CLEC2L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLEC2L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073980.2  
    ENSEMBL proteins: 
     ENSP00000390661   ENSP00000428508  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P0C7M8

    ProtoNet protein and cluster: P0C7M8

    UniProtKB/Swiss-Prot: CLC2L_HUMAN, P0C7M8
    Similarity: Contains 1 C-type lectin domain


    CLEC2L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding IEA--
         
    CLEC2L for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLC2L_HUMAN, P0C7M8: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    CLEC2L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLEC2L
    Interactions:

        Search GeneGlobe Interaction Network for CLEC2L

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CLEC2L (P0C7M83 ENSP000003906614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FIBPO434273, ENSP000003445724I2D: score=1 STRING: ENSP00000344572
    EXT2Q930633, ENSP000003426564I2D: score=1 STRING: ENSP00000342656
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLEC2L (CLC2L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLEC2L gene: 
    NM_001080511.2  

    Unigene Cluster for CLEC2L:

    C-type lectin domain family 2, member L
    Hs.57806  [show with all ESTs]
    Unigene Representative Sequence: AK057548
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422142(uc010lnd.3) ENST00000521281 ENST00000520413
    miRNA
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    hsa-miR-3184 hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-3914 hsa-miR-423-5p hsa-miR-873 hsa-miR-214
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat CLEC2L

    Additional mRNA sequence: AK057548.1 

    2 DOTS entries:

    DT.106974  DT.92039149 

    13 AceView cDNA sequences:

    AK057548 AA325781 BU633379 BV196207 BF945734 AA041192 AA985339 AA041430 
    AI085797 BQ184955 BF792388 AI499740 AA865558 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLEC2L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAGGTACA
    CLEC2L Expression
    About this image

    CLEC2L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLEC2L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.57806
        Custom PCR Arrays for CLEC2L
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC2L gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec2l1 , 5 C-type lectin domain family, member L5
    C-type lectin domain family 2, member L1
    89.26(n)1
    96.11(a)1
      6 (17.85 cM)5
    6651801  NM_001101507.11  NP_001094977.11 
     386630695 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    24(a)
    many ↔ many
    16(223503-225021) ENSGALG00000028962


    ENSEMBL Gene Tree for CLEC2L (if available)
    TreeFam Gene Tree for CLEC2L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLEC2L gene
    CLEC2D2  CLEC2A2  CLEC2B2  CD692  
    13 SIMAP similar genes for CLEC2L using alignment to 2 protein entries:     CLC2L_HUMAN (see all proteins):
    CLEC2D    KLRG1    CD69    FCER2    KLRC1    KLRC2
    CLEC2B    ASGR1    CLEC10A    OLR1    CLEC1B    CLEC2A
    CLEC4C

    CLEC2L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLEC2L (see all 500)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1136754591,2
    F--139206689(+) AATCAG/CAAGCA 1 -- us2k13Minor allele frequency- C:0.05CSA WA 122
    rs1881008811,2
    --139206728(+) GTGCAC/TGGGGG 1 -- us2k10--------
    rs1920332501,2
    --139206767(+) AGGAGA/GTGTGT 1 -- us2k10--------
    rs591382011,2
    C,F--139206773(+) TGTGTT/CCCAGG 1 -- us2k16Minor allele frequency- C:0.21WA CSA NA 244
    rs1432333301,2
    --139206887(+) GAGCAA/GGACTT 1 -- us2k10--------
    rs1164324481,2
    C,F--139206912(+) CTTGAG/AGCCTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs587923061,2
    C,F--139207132(+) CAATGC/GGCAGA 1 -- us2k15Minor allele frequency- G:0.27WA CSA NA 242
    rs1829434781,2
    --139207207(+) GGGAGG/TCCGAG 1 -- us2k10--------
    rs1876396461,2
    --139207232(+) AGGTCA/GGGAGA 1 -- us2k10--------
    rs1925121921,2
    --139207515(+) GGAGAC/TCCAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLEC2L (139208602 - 139229731 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CLEC2L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735212CNV Deletion23290073
    esv24293CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    CLEC2L for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLEC2L

    Export disorders for CLEC2L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLEC2L gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CLEC2L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. (PubMed id 17463248)4 Scott L.J....Boehnke M. (Science 2007)
    2. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 154790 HGNC: 21969 AceView: LOC154790 Ensembl:ENSG00000236279 euGenes: HUgn154790
    ECgene: CLEC2L H-InvDB: CLEC2L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLEC2L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLEC2L gene:
    Search GeneIP for patents involving CLEC2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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