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Aliases for CLEC2L Gene

Aliases for CLEC2L Gene

  • C-Type Lectin Domain Family 2 Member L 2 3 5
  • C-Type Lectin Domain Family 2, Member L 2

External Ids for CLEC2L Gene

Previous GeneCards Identifiers for CLEC2L Gene

  • GC07P138677
  • GC07P138872
  • GC07P139208
  • GC07P133519

Summaries for CLEC2L Gene

GeneCards Summary for CLEC2L Gene

CLEC2L (C-Type Lectin Domain Family 2 Member L) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD69.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC2L Gene

Genomics for CLEC2L Gene

Regulatory Elements for CLEC2L Gene

Enhancers for CLEC2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F139495 0.9 Ensembl ENCODE 12.1 -28.4 -28356 0.6 PKNOX1 EBF1 ZIC2 RELA EED ETV6 CREM SRF MTA2 JUNB CLEC2L ERHP1 ST13P17 KLRG2
GH07F139563 0.2 Ensembl 12 +39.4 39445 0.2 ERHP1 CLEC2L GC07M139562 GC07P139535
GH07F139526 0.2 ENCODE 11.9 +3.5 3493 0.9 BCOR ADNP ZMYM3 FOS CLEC2L ERHP1
GH07F139490 0.2 ENCODE 11.6 -33.5 -33487 0.2 KLF17 CLEC2L ERHP1 KLRG2 ST13P17
GH07F139588 0.6 ENCODE 11.3 +64.9 64933 1.3 CEBPB ZFHX2 ZNF316 EGR1 KLF16 FOXK2 IKZF1 EMSY ERHP1 CLEC2L KDM7A LOC105375530 PIR36040
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CLEC2L on UCSC Golden Path with GeneCards custom track

Promoters for CLEC2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001896925 44 601 ZNF263 SP3 SUZ12 ZNF341 EZH2

Genomic Location for CLEC2L Gene

Chromosome:
7
Start:
139,523,856 bp from pter
End:
139,544,985 bp from pter
Size:
21,130 bases
Orientation:
Plus strand

Genomic View for CLEC2L Gene

Genes around CLEC2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC2L Gene

Proteins for CLEC2L Gene

  • Protein details for CLEC2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7M8-CLC2L_HUMAN
    Recommended name:
    C-type lectin domain family 2 member L
    Protein Accession:
    P0C7M8

    Protein attributes for CLEC2L Gene

    Size:
    214 amino acids
    Molecular mass:
    23927 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC2L Gene

Post-translational modifications for CLEC2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLEC2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLEC2L Gene

Domains & Families for CLEC2L Gene

Gene Families for CLEC2L Gene

Protein Domains for CLEC2L Gene

Suggested Antigen Peptide Sequences for CLEC2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C7M8

UniProtKB/Swiss-Prot:

CLC2L_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC2L: view

Function for CLEC2L Gene

Gene Ontology (GO) - Molecular Function for CLEC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC2L: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC2L Gene

Localization for CLEC2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC2L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC2L Gene COMPARTMENTS Subcellular localization image for CLEC2L gene
Compartment Confidence
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLEC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC2L: view

Pathways & Interactions for CLEC2L Gene

SuperPathways for CLEC2L Gene

No Data Available

Interacting Proteins for CLEC2L Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000390661%0d%0a9606.ENSP00000379032%0d%0a9606.ENSP00000344572%0d%0a
Selected Interacting proteins: ENSP00000390661 P0C7M8-CLC2L_HUMAN for CLEC2L Gene via STRING IID

Gene Ontology (GO) - Biological Process for CLEC2L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLEC2L Gene

Transcripts for CLEC2L Gene

mRNA/cDNA for CLEC2L Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC2L Gene

C-type lectin domain family 2, member L:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC2L Gene

No ASD Table

Relevant External Links for CLEC2L Gene

GeneLoc Exon Structure for
CLEC2L
ECgene alternative splicing isoforms for
CLEC2L

Expression for CLEC2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLEC2L Gene

mRNA differential expression in normal tissues according to GTEx for CLEC2L Gene

This gene is overexpressed in Brain - Cortex (x8.3), Brain - Anterior cingulate cortex (BA24) (x7.4), Brain - Frontal Cortex (BA9) (x7.2), Brain - Cerebellum (x4.3), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for CLEC2L Gene

This gene is overexpressed in Frontal cortex (53.9) and Platelet (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC2L Gene



Protein tissue co-expression partners for CLEC2L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLEC2L Gene:

CLEC2L

SOURCE GeneReport for Unigene cluster for CLEC2L Gene:

Hs.57806
genes like me logo Genes that share expression patterns with CLEC2L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CLEC2L Gene

Orthologs for CLEC2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC2L 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia CLEC2L 35
  • 92 (a)
OneToOne
LOC781590 34
  • 90.74 (n)
rat
(Rattus norvegicus)
Mammalia Clec2l 34
  • 89.81 (n)
mouse
(Mus musculus)
Mammalia Clec2l 34 16 35
  • 89.26 (n)
oppossum
(Monodelphis domestica)
Mammalia CLEC2L 35
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC2L 34 35
  • 82.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 27 (a)
OneToMany
-- 35
  • 27 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 24 (a)
ManyToMany
Species where no ortholog for CLEC2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC2L Gene

ENSEMBL:
Gene Tree for CLEC2L (if available)
TreeFam:
Gene Tree for CLEC2L (if available)

Paralogs for CLEC2L Gene

Paralogs for CLEC2L Gene

(13) SIMAP similar genes for CLEC2L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLEC2L: view

Variants for CLEC2L Gene

Sequence variations from dbSNP and Humsavar for CLEC2L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10239572 -- 139,539,497(+) TGTTC(A/G)TGGAA intron-variant
rs10244543 -- 139,535,096(+) GCTGC(A/G)TTATT intron-variant
rs10247401 -- 139,541,257(+) acccg(C/T)ctagg intron-variant
rs10253060 -- 139,530,336(+) tccag(A/C)gagca intron-variant
rs10259935 -- 139,535,235(+) CAACA(C/T)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC2L Gene

Variant ID Type Subtype PubMed ID
esv24293 CNV gain 19812545
esv2735212 CNV deletion 23290073
esv3615215 CNV gain 21293372
esv3615216 CNV gain 21293372
nsv1119140 CNV deletion 24896259

Variation tolerance for CLEC2L Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC2L Gene

Disorders for CLEC2L Gene

Relevant External Links for CLEC2L

Genetic Association Database (GAD)
CLEC2L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC2L

No disorders were found for CLEC2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC2L Gene

Publications for CLEC2L Gene

  1. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3 64
  2. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. (PMID: 17463248) Scott L.J. … Boehnke M. (Science 2007) 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4 64
  5. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for CLEC2L Gene

Sources for CLEC2L Gene

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