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Aliases for CLEC2D Gene

Aliases for CLEC2D Gene

  • C-Type Lectin Domain Family 2, Member D 2 3
  • Lectin-Like Transcript 1 2 3 4
  • LLT1 3 4 6
  • C-Type Lectin Superfamily 2, Member D 2 3
  • Lectin-Like NK Cell Receptor 3 4
  • Osteoclast Inhibitory Lectin 3 4
  • C-Type Lectin Related F 2 3
  • LLT-1 3 4
  • CLAX 3 4
  • OCIL 3 4
  • C-Type Lectin Domain Family 2 Member D 3

External Ids for CLEC2D Gene

Summaries for CLEC2D Gene

Entrez Gene Summary for CLEC2D Gene

  • This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for CLEC2D Gene

CLEC2D (C-Type Lectin Domain Family 2, Member D) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding and transmembrane signaling receptor activity. An important paralog of this gene is CLEC2A.

UniProtKB/Swiss-Prot for CLEC2D Gene

  • Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.

Gene Wiki entry for CLEC2D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC2D Gene

Genomics for CLEC2D Gene

Genomic Location for CLEC2D Gene

Start:
9,664,969 bp from pter
End:
9,699,555 bp from pter
Size:
34,587 bases
Orientation:
Plus strand

Genomic View for CLEC2D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC2D Gene

Regulatory Elements for CLEC2D Gene

Proteins for CLEC2D Gene

  • Protein details for CLEC2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHP7-CLC2D_HUMAN
    Recommended name:
    C-type lectin domain family 2 member D
    Protein Accession:
    Q9UHP7
    Secondary Accessions:
    • D6CI39
    • D6CI40
    • D6CI41
    • Q6YID5
    • Q8WUP7
    • Q9HD37
    • Q9HD38

    Protein attributes for CLEC2D Gene

    Size:
    191 amino acids
    Molecular mass:
    21849 Da
    Quaternary structure:
    • Homodimer or heterodimer; disulfide-linked

    Three dimensional structures from OCA and Proteopedia for CLEC2D Gene

    Alternative splice isoforms for CLEC2D Gene

neXtProt entry for CLEC2D Gene

Proteomics data for CLEC2D Gene at MOPED

Post-translational modifications for CLEC2D Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn95

No data available for DME Specific Peptides for CLEC2D Gene

Domains for CLEC2D Gene

Gene Families for CLEC2D Gene

HGNC:
  • CLEC :C-type lectin domain containing

Protein Domains for CLEC2D Gene

Suggested Antigen Peptide Sequences for CLEC2D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHP7

UniProtKB/Swiss-Prot:

CLC2D_HUMAN
Domain:
  • Contains 1 C-type lectin domain.:
    • Q9UHP7
genes like me logo Genes that share domains with CLEC2D: view

Function for CLEC2D Gene

Molecular function for CLEC2D Gene

UniProtKB/Swiss-Prot Function: Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.
UniProtKB/Swiss-Prot Induction: Up-regulated by IL1A/interleukin-1 alpha and prostaglandin E2 in cultured osteogenic sarcoma cells.

Gene Ontology (GO) - Molecular Function for CLEC2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10541800
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC2D: view

Phenotypes for CLEC2D Gene

genes like me logo Genes that share phenotypes with CLEC2D: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLEC2D Gene

Localization for CLEC2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC2D Gene

Cell membrane; Single-pass type II membrane protein. Cell surface.
Isoform 2: Endoplasmic reticulum.
Isoform 4: Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC2D Gene COMPARTMENTS Subcellular localization image for CLEC2D gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CLEC2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 20843815
GO:0005887 integral component of plasma membrane TAS 10541800
GO:0009986 cell surface IDA 20843815
GO:0016020 membrane TAS 10541800
genes like me logo Genes that share ontologies with CLEC2D: view

Pathways for CLEC2D Gene

SuperPathways for CLEC2D Gene

No Data Available

Interacting Proteins for CLEC2D Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000261340%0d%0a9606.ENSP00000229402%0d%0a9606.ENSP00000279544%0d%0a9606.ENSP00000254227%0d%0a
Selected Interacting proteins: ENSP00000261340 Q9UHP7-CLC2D_HUMAN for CLEC2D Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CLEC2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 10541800
genes like me logo Genes that share ontologies with CLEC2D: view

No data available for Pathways by source for CLEC2D Gene

Compounds for CLEC2D Gene

(1) Novoseek inferred chemical compound relationships for CLEC2D Gene

Compound -log(P) Hits PubMed IDs
dexamethasone 19.6 1
genes like me logo Genes that share compounds with CLEC2D: view

Transcripts for CLEC2D Gene

Unigene Clusters for CLEC2D Gene

C-type lectin domain family 2, member D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC2D Gene

No ASD Table

Relevant External Links for CLEC2D Gene

GeneLoc Exon Structure for
CLEC2D
ECgene alternative splicing isoforms for
CLEC2D

Expression for CLEC2D Gene

mRNA expression in normal human tissues for CLEC2D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC2D Gene

This gene is overexpressed in Whole Blood (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLEC2D Gene

SOURCE GeneReport for Unigene cluster for CLEC2D Gene Hs.268326

mRNA Expression by UniProt/SwissProt for CLEC2D Gene

Q9UHP7-CLC2D_HUMAN
Tissue specificity: Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells.
genes like me logo Genes that share expressions with CLEC2D: view

Orthologs for CLEC2D Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC2D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC2D 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 30 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CLEC2D 35
  • 77.31 (n)
  • 64.92 (a)
CLEC2D 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec2d 36
  • 29 (a)
OneToMany
Clec2e 36
  • 29 (a)
OneToMany
Clec2g 36
  • 22 (a)
OneToMany
Clec2h 36
  • 26 (a)
OneToMany
Clec2i 16
Clec2j 36
  • 33 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Clec2h 35
  • 63.64 (n)
  • 53.15 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 32 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
ManyToMany
-- 36
  • 18 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
Species with no ortholog for CLEC2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC2D Gene

ENSEMBL:
Gene Tree for CLEC2D (if available)
TreeFam:
Gene Tree for CLEC2D (if available)

Paralogs for CLEC2D Gene

Paralogs for CLEC2D Gene

Pseudogenes.org Pseudogenes for CLEC2D Gene

genes like me logo Genes that share paralogs with CLEC2D: view

Variants for CLEC2D Gene

Sequence variations from dbSNP and Humsavar for CLEC2D Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs969367 -- 9,668,986(+) AATGT(C/G)TTTAG upstream-variant-2KB
rs1118223 -- 9,674,105(+) TTCTC(A/G)TGCCT intron-variant
rs1131767 -- 9,691,791(+) ttaac(A/T)aaaaa intron-variant
rs1560011 -- 9,670,356(+) TATCA(A/G)GGTTT intron-variant
rs2080210 -- 9,685,456(-) agcac(C/G)tgggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC2D Gene

Variant ID Type Subtype PubMed ID
dgv466e1 CNV Complex 17122850
nsv428271 CNV Gain 18775914
dgv468e1 CNV Complex 17122850

Relevant External Links for CLEC2D Gene

HapMap Linkage Disequilibrium report
CLEC2D
Human Gene Mutation Database (HGMD)
CLEC2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC2D Gene

Disorders for CLEC2D Gene

Relevant External Links for CLEC2D

Genetic Association Database (GAD)
CLEC2D
Human Genome Epidemiology (HuGE) Navigator
CLEC2D
genes like me logo Genes that share disorders with CLEC2D: view

No data available for UniProtKB/Swiss-Prot for CLEC2D Gene

Publications for CLEC2D Gene

  1. Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts. (PMID: 14753741) Hu Y.S. … Ng K.W. (J. Bone Miner. Res. 2004) 3 4 23
  2. The LLT1 receptor induces IFN-gamma production by human natural killer cells. (PMID: 15104121) Mathew P.A. … Pham H.T. (Mol. Immunol. 2004) 3 4 23
  3. Characterization of sugar binding by osteoclast inhibitory lectin. (PMID: 15123656) Gange C.T. … Ng K.W. (J. Biol. Chem. 2004) 3 4 23
  4. Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. (PMID: 16339513) Rosen D.B. … Lanier L.L. (J. Immunol. 2005) 3 4 23
  5. The Asn19Lys substitution in the osteoclast inhibitory lectin (OCIL) gene is associated with a reduction of bone mineral density in postmenopausal women. (PMID: 18465072) Pineda B. … GarcA-a-PAcrez M.A. (Calcif. Tissue Int. 2008) 3 23 48

Products for CLEC2D Gene

Sources for CLEC2D Gene

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