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CLEC2D Gene

protein-coding   GIFtS: 51
GCID: GC12P009817

C-Type Lectin Domain Family 2, Member D

(Previous names: C-type lectin superfamily 2, member D)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C-Type Lectin Domain Family 2, Member D1 2     Osteoclast Inhibitory Lectin2 3
Lectin-Like Transcript 11 2 3     CLAX2 3
LLT12 3 5     LLT-12 3
C-Type Lectin Superfamily 2, Member D1 2     OCIL2 3
C-Type Lectin Related F1 2     C-Type Lectin Domain Family 2 Member D2
Lectin-Like NK Cell Receptor2 3     

External Ids:    HGNC: 143511   Entrez Gene: 291212   Ensembl: ENSG000000694937   OMIM: 6056595   UniProtKB: Q9UHP73   

Export aliases for CLEC2D gene to outside databases

Previous GC identifers: GC12P009715 GC12P009809 GC12P009565


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLEC2D Gene:
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits
osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like
extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.
(provided by RefSeq, Oct 2010)

GeneCards Summary for CLEC2D Gene:
CLEC2D (C-type lectin domain family 2, member D) is a protein-coding gene. Diseases associated with CLEC2D include malignant glioma, and inflammatory bowel disease. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLEC2L.

UniProtKB/Swiss-Prot: CLC2D_HUMAN, Q9UHP7
Function: Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits
osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular
weight sulfated glycosaminoglycans

Gene Wiki entry for CLEC2D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLEC2D gene promoter:
         AREB6   FAC1   AP-1   Roaz   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC2D promoter sequence
   Search Chromatin IP Primers for CLEC2D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC2D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

CLEC2D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC2D gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P009817:  view genomic region     (about GC identifiers)

Start:
9,817,565 bp from pter      End:
9,852,151 bp from pter
Size:
34,587 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLC2D_HUMAN, Q9UHP7 (See protein sequence)
Recommended Name: C-type lectin domain family 2 member D  
Size: 191 amino acids; 21849 Da
Subunit: Homodimer or heterodimer; disulfide-linked
Secondary accessions: D6CI39 D6CI40 D6CI41 Q6YID5 Q8WUP7 Q9HD37 Q9HD38
Alternative splicing: 6 isoforms:  Q9UHP7-1   Q9UHP7-2   Q9UHP7-3   Q9UHP7-5   Q9UHP7-6   Q9UHP7-7   

Explore the universe of human proteins at neXtProt for CLEC2D: NX_Q9UHP7

Explore proteomics data for CLEC2D at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn95
  • Modification sites at PhosphoSitePlus

  • See CLEC2D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001004419.1  NP_001184246.1  NP_001184247.1  NP_001184248.1  NP_037401.1  

    ENSEMBL proteins: 
     ENSP00000438735   ENSP00000261340   ENSP00000290855   ENSP00000371409   ENSP00000443110  
     ENSP00000399744   ENSP00000441653   ENSP00000444818   ENSP00000443065   ENSP00000261339  
     ENSP00000446028   ENSP00000443627   ENSP00000413045   ENSP00000437861   ENSP00000443177  

    CLEC2D Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

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    CLEC2D Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q9UHP7

    ProtoNet protein and cluster: Q9UHP7

    UniProtKB/Swiss-Prot: CLC2D_HUMAN, Q9UHP7
    Similarity: Contains 1 C-type lectin domain


    CLEC2D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLC2D_HUMAN, Q9UHP7
    Function: Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits
    osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular
    weight sulfated glycosaminoglycans
    Induction: Up-regulated by IL1A/interleukin-1 alpha and prostaglandin E2 in cultured osteogenic sarcoma cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS10541800
    GO:0030246carbohydrate binding IEA--
         
    CLEC2D for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CLEC2D:
     Decreased viability  Increased S DNA content  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLEC2D
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC2D
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    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CLEC2D:
    hsa-miR-1291
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Sino Biological Human cDNA Clone for CLEC2D
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC2D

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLC2D_HUMAN, Q9UHP7: Cell membrane; Single-pass type II membrane protein. Cell surface
    CLC2D_HUMAN, Q9UHP7: Isoform 2: Endoplasmic reticulum
    CLC2D_HUMAN, Q9UHP7: Isoform 4: Endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005887integral component of plasma membrane TAS10541800
    GO:0009986cell surface IDA--
    GO:0016020membrane TAS10541800

    CLEC2D for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLEC2D
    Interactions:

        Search GeneGlobe Interaction Network for CLEC2D

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CLEC2D (Q9UHP73 ENSP000002613404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLRB1Q129183, ENSP000002294024I2D: score=1 STRING: ENSP00000229402
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS10541800

    CLEC2D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLEC2D (CLC2D)

    1 Novoseek inferred chemical compound relationship for CLEC2D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dexamethasone 19.6 1 17049328 (1)



    CLEC2D for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLEC2D gene (6 alternative transcripts): 
    NM_001004419.4  NM_001197317.2  NM_001197318.2  NM_001197319.2  NM_013269.5  NM_001004420.1  

    Unigene Cluster for CLEC2D:

    C-type lectin domain family 2, member D
    Hs.268326  [show with all ESTs]
    Unigene Representative Sequence: NM_001004419
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536355 ENST00000487752 ENST00000261340 ENST00000290855 ENST00000325960(uc009zgs.2)
    ENST00000492359 ENST00000444971(uc001qwf.2 uc009zgt.2 uc009zgu.2 uc001qwg.2 uc021quv.1 uc021quw.1 uc001qwh.2)
    ENST00000479877 ENST00000545918 ENST00000543300 ENST00000261339 ENST00000466035
    ENST00000476198 ENST00000430909 ENST00000544322 ENST00000460309
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CLEC2D:
    hsa-miR-1291
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CLEC2D
      QuantiFast Probe-based Assays in human, mouse, rat CLEC2D

    Additional mRNA sequence: 

    AF133299.1 AF285087.1 AF285088.1 AF285089.1 AK310554.1 AK313554.1 AL833366.1 BC094859.1 
    FN813349.1 FN813350.1 FN813351.1 NR_036693.2 

    19 DOTS entries:

    DT.111642  DT.100783581  DT.40310763  DT.92423012  DT.409066  DT.91744030  DT.97837669  DT.87016034 
    DT.92423011  DT.97799003  DT.121123299  DT.92423013  DT.95268484  DT.121123277  DT.121123289  DT.87008899 
    DT.99964549  DT.100740963  DT.91783476 

    Selected AceView cDNA sequences (see all 213):

    F12384 BE676787 BG231836 AA812216 R83089 AA814894 NM_001004419 AI246121 
    AA279198 BX279958 BF513581 NM_001004420 CA394221 F07738 BM466188 CR598820 
    AA748560 BU153495 AA737464 AA732314 NM_013269 AA884484 AF285089 BU150039 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLEC2D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLEC2D Expression
    About this image


    CLEC2D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Thymus
    CLEC2D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLEC2D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.268326

    UniProtKB/Swiss-Prot: CLC2D_HUMAN, Q9UHP7
    Tissue specificity: Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform
    1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also
    expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC2D gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec2i5 C-type lectin domain family 2, member i   --   6 (63.10 cM) 128887588 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    32(a)
    many ↔ many
    16(223503-225021)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    23(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2(193112946-193126895)
    GL343438.1(61100-123526)


    ENSEMBL Gene Tree for CLEC2D (if available)
    TreeFam Gene Tree for CLEC2D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLEC2D gene
    CLEC2L2  CLEC2A2  CLEC2B2  CD692  
    Selected SIMAP similar genes for CLEC2D using alignment to 7 protein entries:     CLC2D_HUMAN (see all proteins) (see all similar genes):
    NPM1    FCER2    GNPTAB    CLEC2B    CLEC2L    FANCA
    CLEC2A    SERF1B    CD69    CLEC10A    NPAT    KLRD1
    ASGR1    CLEC4C    CNOT2    KLRC1    KLRC2    KLRG1

    CLEC2D for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLEC2D
    PGOHUM00000239665


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLEC2D (see all 702)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452667231,2
    C--9820328(+) CAGTCA/CTGGGT 6 -- us2k10--------
    rs1117540201,2
    C,F--9820427(+) AGTTAC/TGCCAA 6 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs105824821,2
    C--9820439(+) TAAATAAG/-AACAC 11 -- us2k1 cds11Minor allele frequency- -:0.50NA 2
    rs1478025791,2
    C--9820439(+) TAAAT-/AAGAACAC 6 -- us2k10--------
    rs125827891,2
    C,F,H--9820495(+) TAATAA/GCCTGG 6 -- us2k16Minor allele frequency- G:0.02NS EA NA 542
    rs107720101,2
    C,F,A,H--9820575(+) GGAAAT/ATCCAA 6 -- us2k1 tfbs323Minor allele frequency- A:0.33NS EA NA WA CSA 2337
    rs2002017021,2
    --9820586(+) GATGA-/TTAGTGT 6 -- us2k10--------
    rs64881001,2
    C,F,H--9820619(+) GAAATT/CTCAAT 6 -- us2k119Minor allele frequency- C:0.16NS EA NA WA CSA 931
    rs1495383331,2
    --9820711(+) TATCCA/GCTTCT 6 -- us2k10--------
    rs1441320751,2
    --9820765(+) AACAAC/GTAGAA 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLEC2D (9817565 - 9852151 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CLEC2D:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428271CNV Gain18775914
    dgv466e1CNV Complex17122850
    dgv468e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CLEC2D
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLEC2D
    DNA2.0 Custom Variant and Variant Library Synthesis for CLEC2D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605659    OMIM disorders: --

    3 diseases for CLEC2D:    
    About MalaCards
    malignant glioma    inflammatory bowel disease    sarcoma


    CLEC2D for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLEC2D
    Human Genome Epidemiology (HuGE) Navigator: CLEC2D (2 documents)

    Export disorders for CLEC2D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLEC2D gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with CLEC2D)
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    1. Characterization of sugar binding by osteoclast inhibitory lectin. (PubMed id 15123656)1, 2, 9 Gange C.T....Ng K.W. (J. Biol. Chem. 2004)
    2. The LLT1 receptor induces IFN-gamma production by human natural killer cells. (PubMed id 15104121)1, 2, 9 Mathew P.A....Pham H.T. (Mol. Immunol. 2004)
    3. Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts. (PubMed id 14753741)1, 2, 9 Hu Y.S.... Ng K.W. (J. Bone Miner. Res. 2004)
    4. The Asn19Lys substitution in the osteoclast inhibitory lectin (OCIL) gene is associated with a reduction of bone mineral density in postmenopausal women. (PubMed id 18465072)1, 4, 9 Pineda B....GarcA-a-PAcrez M.A. (Calcif. Tissue Int. 2008)
    5. Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. (PubMed id 16339513)1, 2, 9 Rosen D.B....Lanier L.L. (J. Immunol. 2005)
    6. Characterization of alternatively spliced transcript variants of CLEC2D gene. (PubMed id 20843815)1, 2 Germain C.... Braud V.M. (J. Biol. Chem. 2010)
    7. Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency. (PubMed id 18593762)1, 4 Skinningsrud B....Undlien D.E. (J. Clin. Endocrinol. Metab. 2008)
    8. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1, 4 (Nature 2007)
    9. Cloning of a new lectin-like receptor expressed on human NK cells. (PubMed id 10541800)1, 2 Boles K.S.... Mathew P.A. (Immunogenetics 1999)
    10. Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells. (PubMed id 18453569)1, 9 Rosen D.B....Lanier L.L. (J. Immunol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29121 HGNC: 14351 AceView: OCIL Ensembl:ENSG00000069493 euGenes: HUgn29121
    ECgene: CLEC2D H-InvDB: CLEC2D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLEC2D Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_242

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLEC2D gene:
    Search GeneIP for patents involving CLEC2D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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