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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC2D Gene

protein-coding   GIFtS: 51
GCID: GC12P009809

C-Type Lectin Domain Family 2, Member D

(Previous names: C-type lectin superfamily 2, member D)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
C-Type Lectin Domain Family 2, Member D1 2     Osteoclast Inhibitory Lectin2 3
Lectin-Like Transcript 11 2 3     CLAX2 3
LLT12 3 5     LLT-12 3
C-Type Lectin Superfamily 2, Member D1 2     OCIL2 3
C-Type Lectin Related F1 2     C-Type Lectin Domain Family 2 Member D2
Lectin-Like NK Cell Receptor2 3     

External Ids:    HGNC: 143511   Entrez Gene: 291212   Ensembl: ENSG000000694937   OMIM: 6056595   UniProtKB: Q9UHP73   
ORGUL members:         
NONCODE14:n410190      

Export aliases for CLEC2D gene to outside databases

Previous GC identifers: GC12P009715 GC12P009565


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLEC2D Gene:
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits
osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like
extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.
(provided by RefSeq, Oct 2010)

GeneCards Summary for CLEC2D Gene: 
CLEC2D (C-type lectin domain family 2, member D) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CLEC2D include malignant glioma, and inflammatory bowel disease. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLEC2L.

UniProtKB/Swiss-Prot: CLC2D_HUMAN, Q9UHP7
Function: Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits
osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular
weight sulfated glycosaminoglycans

Gene Wiki entry for CLEC2D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC2D gene promoter:
         AREB6   FAC1   AP-1   Roaz   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC2D promoter sequence
   Search SABiosciences Chromatin IP Primers for CLEC2D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC2D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

CLEC2D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC2D gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P009809:  view genomic region     (about GC identifiers)

Start:
9,809,270 bp from pter      End:
9,852,151 bp from pter
Size:
42,882 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLC2D_HUMAN, Q9UHP7 (See protein sequence)
Recommended Name: C-type lectin domain family 2 member D  
Size: 191 amino acids; 21849 Da
Subunit: Homodimer or heterodimer; disulfide-linked
Subcellular location: Cell membrane; Single-pass type II membrane protein. Cell surface
Subcellular location: Isoform 2: Endoplasmic reticulum
Subcellular location: Isoform 4: Endoplasmic reticulum
Secondary accessions: D6CI39 D6CI40 D6CI41 Q6YID5 Q8WUP7 Q9HD37 Q9HD38
Alternative splicing: 6 isoforms:  Q9UHP7-1   Q9UHP7-2   Q9UHP7-3   Q9UHP7-5   Q9UHP7-6   Q9UHP7-7   

Explore the universe of human proteins at neXtProt for CLEC2D: NX_Q9UHP7

Explore proteomics data for CLEC2D at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHP7

  • CLEC2D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLEC2D Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001004419.1  NP_001184246.1  NP_001184247.1  NP_001184248.1  NP_037401.1  

    ENSEMBL proteins: 
     ENSP00000442252   ENSP00000438735   ENSP00000261340   ENSP00000290855   ENSP00000371409  
     ENSP00000443110   ENSP00000399744   ENSP00000441653   ENSP00000444818   ENSP00000443065  
     ENSP00000261339   ENSP00000446028   ENSP00000443627   ENSP00000413045   ENSP00000437861  
     ENSP00000443177  

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    Sino Biological Recombinant Protein for CLEC2D
    Sino Biological Cell Lysate for CLEC2D 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005887integral to plasma membrane TAS10541800
    GO:0009986cell surface IDA--
    GO:0016020membrane TAS10541800

    CLEC2D for ontologies           About GeneDecksing



    CLEC2D Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q9UHP7

    ProtoNet protein and cluster: Q9UHP7

    UniProtKB/Swiss-Prot: CLC2D_HUMAN, Q9UHP7
    Similarity: Contains 1 C-type lectin domain


    CLEC2D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLC2D_HUMAN, Q9UHP7
    Function: Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits
    osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular
    weight sulfated glycosaminoglycans
    Induction: Up-regulated by IL1A/interleukin-1 alpha and prostaglandin E2 in cultured osteogenic sarcoma cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS10541800
    GO:0030246carbohydrate binding IEA--
         
    CLEC2D for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CLEC2D:
     Decreased viability  Increased S DNA content  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLEC2D 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC2D 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CLEC2D:
    hsa-miR-1291
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CLEC2D

    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of CLEC2D 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC2D


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC2D

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CLEC2D (Q9UHP73 ENSP000002613404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLRB1Q129183, ENSP000002294024I2D: score=1 STRING: ENSP00000229402
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS10541800

    CLEC2D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLEC2D for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLEC2D (CLC2D)

    1 Novoseek inferred chemical compound relationship for CLEC2D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dexamethasone 19.6 1 17049328 (1)

    Search CenterWatch for drugs/clinical trials and news about CLEC2D / CLC2D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLEC2D gene (6 alternative transcripts): 
    NM_001004419.4  NM_001197317.2  NM_001197318.2  NM_001197319.2  NM_013269.5  NM_001004420.1  

    Unigene Cluster for CLEC2D:

    C-type lectin domain family 2, member D
    Hs.268326  [show with all ESTs]
    Unigene Representative Sequence: NM_001004419
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479410 ENST00000536355 ENST00000487752 ENST00000261340 ENST00000290855
    ENST00000325960(uc009zgs.2) ENST00000492359 ENST00000444971(uc001qwf.2 uc009zgt.2 uc009zgu.2 uc001qwg.2 uc021quv.1 uc021quw.1 uc001qwh.2)
    ENST00000479877 ENST00000545918 ENST00000543300 ENST00000261339 ENST00000466035
    ENST00000476198 ENST00000430909 ENST00000544322 ENST00000460309
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CLEC2D:
    hsa-miR-1291
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC2D
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC2D

    Additional mRNA sequence: 

    AF133299.1 AF285087.1 AF285088.1 AF285089.1 AK310554.1 AK313554.1 AL833366.1 BC094859.1 
    FN813349.1 FN813350.1 FN813351.1 NR_036693.2 

    19 DOTS entries:

    DT.111642  DT.100783581  DT.40310763  DT.92423012  DT.409066  DT.91744030  DT.97837669  DT.87016034 
    DT.92423011  DT.97799003  DT.121123299  DT.92423013  DT.95268484  DT.121123277  DT.121123289  DT.87008899 
    DT.99964549  DT.100740963  DT.91783476 

    24/213 AceView cDNA sequences (see all 213):

    F07738 BG231836 R83089 BM466188 AA262688 CR598820 AI073335 AA812216 
    BF513581 NM_001004420 F12384 AF285089 AW167123 BE676787 BU150039 AF285088 
    CA443568 AA279217 NM_013269 BG232105 CA394221 AA748560 BX279958 AA732314 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLEC2D expression in normal human tissues (normalized intensities)      CLEC2D embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLEC2D Expression
    About this image


    CLEC2D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Thymus
     
     Lymph (Hematopoietic System)
             LYMPH NODE   

    See CLEC2D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLEC2D

    SOURCE GeneReport for Unigene cluster: Hs.268326

    UniProtKB/Swiss-Prot: CLC2D_HUMAN, Q9UHP7
    Tissue specificity: Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform
    1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also
    expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC2D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC2D gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec2i5
    Clec2g1
    C-type lectin domain family 2, member i5
    C-type lectin domain family 2, member g1
    61.11(n)1
    50.69(a)1
      6 (63.10 cM)5
    708091  NM_027562.41  NP_081838.11 
     1288875885 
    chicken
    (Gallus gallus)
    Aves LOC1008571591 C-type lectin domain family 2 member D6-like 54.27(n)
    44.87(a)
      100857159  XM_003643221.1  XP_003643269.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    --
    26(a)
    24(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    GL343438.1(61100-123526)
    2(193112946-193126895)
    zebrafish
    (Danio rerio)
    Actinopterygii --
    --
    12(a)
    possible ortholog
    16(14031039-14044474)


    ENSEMBL Gene Tree for CLEC2D (if available)
    TreeFam Gene Tree for CLEC2D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLEC2D gene
    CLEC2L2  CLEC2A2  CLEC2B2  CD692  
    18/23 SIMAP similar genes for CLEC2D using alignment to 8 protein entries:     CLC2D_HUMAN (see all proteins) (see all similar genes):
    NPM1    FCER2    GNPTAB    CLEC2B    CLEC2L    FANCA
    CLEC2A    SERF1B    KLRD1    CD69    CLEC10A    NPAT
    ASGR1    CLEC4C    CNOT2    KLRC1    KLRC2    KLRG1

    CLEC2D for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLEC2D
    PGOHUM00000239665


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/702 SNPs in CLEC2D are shown (see all 702)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452667231,2
    C--9820328(+) CAGTCA/CTGGGT 6 -- us2k10--------
    rs1117540201,2
    C,F--9820427(+) AGTTAC/TGCCAA 6 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs105824821,2
    C--9820439(+) TAAATAAG/-AACAC 11 -- us2k1 cds11Minor allele frequency- -:0.50NA 2
    rs1478025791,2
    C--9820439(+) TAAAT-/AAGAACAC 6 -- us2k10--------
    rs125827891,2
    C,F,H--9820495(+) TAATAA/GCCTGG 6 -- us2k16Minor allele frequency- G:0.02NS EA NA 542
    rs107720101,2
    C,F,A,H--9820575(+) GGAAAT/ATCCAA 6 -- us2k1 tfbs323Minor allele frequency- A:0.33NS EA NA WA CSA 2337
    rs2002017021,2
    --9820586(+) GATGA-/TTAGTGT 6 -- us2k10--------
    rs64881001,2
    C,F,H--9820619(+) GAAATT/CTCAAT 6 -- us2k119Minor allele frequency- C:0.16NS EA NA WA CSA 931
    rs1495383331,2
    --9820711(+) TATCCA/GCTTCT 6 -- us2k10--------
    rs1441320751,2
    --9820765(+) AACAAC/GTAGAA 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLEC2D (9809270 - 9852151 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CLEC2D:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv428271CNV Gain18775914
    dgv466e1CNV Complex17122850
    dgv468e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): CLEC2D
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLEC2D
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605659    OMIM disorders: --

    3 diseases for CLEC2D:    About MalaCards
    malignant glioma    inflammatory bowel disease    sarcoma


    CLEC2D for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLEC2D
    Human Genome Epidemiology (HuGE) Navigator: CLEC2D (2 documents)

    Export disorders for CLEC2D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLEC2D gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with CLEC2D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of sugar binding by osteoclast inhibitory lectin. (PubMed id 15123656)1, 2, 9 Gange C.T....Ng K.W. (2004)
    2. The LLT1 receptor induces IFN-gamma production by human natural killer cells. (PubMed id 15104121)1, 2, 9 Mathew P.A....Pham H.T. (2004)
    3. Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts. (PubMed id 14753741)1, 2, 9 Hu Y.S....Ng K.W. (2004)
    4. The Asn19Lys substitution in the osteoclast inhibitory lectin (OCIL) gene is associated with a reduction of bone mineral density in postmenopausal women. (PubMed id 18465072)1, 4, 9 Pineda B....Garcia-Perez M.A. (2008)
    5. Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. (PubMed id 16339513)1, 2, 9 Rosen D.B....Lanier L.L. (2005)
    6. Characterization of alternatively spliced transcript variants of CLEC2D gene. (PubMed id 20843815)1, 2 Germain C....PadkjA (2010)
    7. Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency. (PubMed id 18593762)1, 4 Skinningsrud B....Undlien D.E. (2008)
    8. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1, 4  . (2007)
    9. Cloning of a new lectin-like receptor expressed on human NK cells. (PubMed id 10541800)1, 2 Boles K.S.... Mathew P.A. (1999)
    10. Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells. (PubMed id 18453569)1, 9 Rosen D.B....Lanier L.L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29121 HGNC: 14351 AceView: OCIL Ensembl:ENSG00000069493 euGenes: HUgn29121
    ECgene: CLEC2D H-InvDB: CLEC2D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLEC2D Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_242

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLEC2D gene:
    Search GeneIP for patents involving CLEC2D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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