Aliases for CLEC2D Gene
External Ids for CLEC2D Gene
Previous GeneCards Identifiers for CLEC2D Gene
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010]
GeneCards Summary for CLEC2D Gene
CLEC2D (C-Type Lectin Domain Family 2 Member D) is a Protein Coding gene. Diseases associated with CLEC2D include Inflammatory Bowel Disease 6. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLEC2A.
UniProtKB/Swiss-Prot for CLEC2D Gene
Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.