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Aliases for CLEC2D Gene

Aliases for CLEC2D Gene

  • C-Type Lectin Domain Family 2 Member D 2 3 5
  • Lectin-Like Transcript 1 2 3 4
  • C-Type Lectin Domain Family 2, Member D 2 3
  • C-Type Lectin Superfamily 2, Member D 2 3
  • Lectin-Like NK Cell Receptor 3 4
  • Osteoclast Inhibitory Lectin 3 4
  • C-Type Lectin Related F 2 3
  • LLT-1 3 4
  • CLAX 3 4
  • LLT1 3 4
  • OCIL 3 4

External Ids for CLEC2D Gene

Previous GeneCards Identifiers for CLEC2D Gene

  • GC12P009715
  • GC12P009809
  • GC12P009565
  • GC12P009817

Summaries for CLEC2D Gene

Entrez Gene Summary for CLEC2D Gene

  • This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for CLEC2D Gene

CLEC2D (C-Type Lectin Domain Family 2 Member D) is a Protein Coding gene. Among its related pathways are Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions and Immune System. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLEC2L.

UniProtKB/Swiss-Prot for CLEC2D Gene

  • Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.

Gene Wiki entry for CLEC2D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC2D Gene

Genomics for CLEC2D Gene

Regulatory Elements for CLEC2D Gene

Enhancers for CLEC2D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLEC2D on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC2D Gene

9,664,969 bp from pter
9,699,555 bp from pter
34,587 bases
Plus strand

Genomic View for CLEC2D Gene

Genes around CLEC2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC2D Gene

Proteins for CLEC2D Gene

  • Protein details for CLEC2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 2 member D
    Protein Accession:
    Secondary Accessions:
    • D6CI39
    • D6CI40
    • D6CI41
    • Q6YID5
    • Q8WUP7
    • Q9HD37
    • Q9HD38

    Protein attributes for CLEC2D Gene

    191 amino acids
    Molecular mass:
    21849 Da
    Quaternary structure:
    • Homodimer or heterodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for CLEC2D Gene

    Alternative splice isoforms for CLEC2D Gene

neXtProt entry for CLEC2D Gene

Proteomics data for CLEC2D Gene at MOPED

Post-translational modifications for CLEC2D Gene

  • Glycosylation at Asn 95
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLEC2D Gene

Domains & Families for CLEC2D Gene

Gene Families for CLEC2D Gene

Protein Domains for CLEC2D Gene

Suggested Antigen Peptide Sequences for CLEC2D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC2D: view

Function for CLEC2D Gene

Molecular function for CLEC2D Gene

UniProtKB/Swiss-Prot Function:
Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL1A/interleukin-1 alpha and prostaglandin E2 in cultured osteogenic sarcoma cells.
genes like me logo Genes that share phenotypes with CLEC2D: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC2D Gene

Localization for CLEC2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC2D Gene

Cell membrane; Single-pass type II membrane protein. Cell surface.
Isoform 2: Endoplasmic reticulum.
Isoform 4: Endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for CLEC2D Gene COMPARTMENTS Subcellular localization image for CLEC2D gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CLEC2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 20843815
GO:0005887 integral component of plasma membrane TAS 10541800
GO:0016020 membrane TAS 10541800
genes like me logo Genes that share ontologies with CLEC2D: view

Pathways & Interactions for CLEC2D Gene

genes like me logo Genes that share pathways with CLEC2D: view

Interacting Proteins for CLEC2D Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000261340 Q9UHP7-CLC2D_HUMAN for CLEC2D Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CLEC2D Gene


No data available for SIGNOR curated interactions for CLEC2D Gene

Drugs & Compounds for CLEC2D Gene

(1) Drugs for CLEC2D Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CLEC2D: view

Transcripts for CLEC2D Gene

Unigene Clusters for CLEC2D Gene

C-type lectin domain family 2, member D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC2D Gene

No ASD Table

Relevant External Links for CLEC2D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC2D Gene

mRNA expression in normal human tissues for CLEC2D Gene

mRNA differential expression in normal tissues according to GTEx for CLEC2D Gene

This gene is overexpressed in Whole Blood (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC2D Gene

SOURCE GeneReport for Unigene cluster for CLEC2D Gene Hs.268326

mRNA Expression by UniProt/SwissProt for CLEC2D Gene

Tissue specificity: Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells.
genes like me logo Genes that share expression patterns with CLEC2D: view

Protein tissue co-expression partners for CLEC2D Gene

- Elite partner

Primer Products

No data available for Protein differential expression in normal tissues for CLEC2D Gene

Orthologs for CLEC2D Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC2D Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia CLEC2D 35
  • 77.31 (n)
  • 64.92 (a)
  • 48 (a)
(Rattus norvegicus)
Mammalia Clec2h 35
  • 63.64 (n)
  • 53.15 (a)
(Bos Taurus)
Mammalia -- 36
  • 30 (a)
-- 36
  • 32 (a)
(Mus musculus)
Mammalia Clec2d 36
  • 29 (a)
Clec2e 36
  • 29 (a)
Clec2g 36
  • 22 (a)
Clec2h 36
  • 26 (a)
Clec2j 36
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
(Pan troglodytes)
Mammalia CLEC2D 36
  • 99 (a)
(Gallus gallus)
Aves -- 36
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
-- 36
  • 18 (a)
-- 36
  • 22 (a)
Species with no ortholog for CLEC2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC2D Gene

Gene Tree for CLEC2D (if available)
Gene Tree for CLEC2D (if available)

Paralogs for CLEC2D Gene

Paralogs for CLEC2D Gene Pseudogenes for CLEC2D Gene

genes like me logo Genes that share paralogs with CLEC2D: view

Variants for CLEC2D Gene

Sequence variations from dbSNP and Humsavar for CLEC2D Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs16914640 - 9,669,791(+) GCAAA(C/G/T)CCAGG nc-transcript-variant, reference, missense
rs3764022 - 9,680,928(-) ATGCA(C/G/T)ACAAC intron-variant, nc-transcript-variant, reference, missense
rs2080210 -- 9,685,456(-) agcac(C/G)tgggg intron-variant
rs2080211 -- 9,685,402(-) CTGCC(A/G)GCCAG intron-variant
rs2894 -- 9,696,287(-) TCAAC(C/T)GTTAC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CLEC2D Gene

Variant ID Type Subtype PubMed ID
dgv466e1 CNV Complex 17122850
nsv428271 CNV Gain 18775914
dgv468e1 CNV Complex 17122850

Variation tolerance for CLEC2D Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.42; 63.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC2D Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC2D Gene

Disorders for CLEC2D Gene

Relevant External Links for CLEC2D

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLEC2D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC2D Gene

Publications for CLEC2D Gene

  1. Characterization of sugar binding by osteoclast inhibitory lectin. (PMID: 15123656) Gange C.T. … Ng K.W. (J. Biol. Chem. 2004) 3 4 23 67
  2. LLT1-mediated activation of IFN-gamma production in human natural killer cells involves ERK signalling pathway. (PMID: 20415786) Bambard N.D. … Mathew P.A. (Scand. J. Immunol. 2010) 3 23
  3. Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells. (PMID: 18453569) Rosen D.B. … Lanier L.L. (J. Immunol. 2008) 3 23
  4. The Asn19Lys substitution in the osteoclast inhibitory lectin (OCIL) gene is associated with a reduction of bone mineral density in postmenopausal women. (PMID: 18465072) Pineda B. … GarcA-a-PAcrez M.A. (Calcif. Tissue Int. 2008) 3 23
  5. Lectin-like transcript 1 is a ligand for the CD161 receptor. (PMID: 16339512) Aldemir H. … Braud V.M. (J. Immunol. 2005) 3 23

Products for CLEC2D Gene

Sources for CLEC2D Gene