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Aliases for CLEC2B Gene

Aliases for CLEC2B Gene

  • C-Type Lectin Domain Family 2, Member B 2 3
  • CLECSF2 3 4 6
  • AICL 3 4 6
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 2 (Activation-Induced) 2 3
  • IFN-Alpha-2b-Inducing-Related Protein 1 3 4
  • C-Type Lectin Superfamily Member 2 3 4
  • Activation-Induced C-Type Lectin 3 4
  • IFNRG1 3 4
  • C-Type Lectin Domain Family 2 Member B 3
  • IFN-Alpha2b-Inducing Related Protein 1 3
  • HP10085 3

External Ids for CLEC2B Gene

Previous HGNC Symbols for CLEC2B Gene

  • CLECSF2

Previous GeneCards Identifiers for CLEC2B Gene

  • GC12M009898
  • GC12M010004
  • GC12M009747

Summaries for CLEC2B Gene

Entrez Gene Summary for CLEC2B Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLEC2B Gene

CLEC2B (C-Type Lectin Domain Family 2, Member B) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC2A.

Gene Wiki entry for CLEC2B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC2B Gene

Genomics for CLEC2B Gene

Genomic Location for CLEC2B Gene

Start:
9,852,369 bp from pter
End:
9,870,136 bp from pter
Size:
17,768 bases
Orientation:
Minus strand

Genomic View for CLEC2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC2B Gene

No data available for Regulatory Elements for CLEC2B Gene

Proteins for CLEC2B Gene

  • Protein details for CLEC2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92478-CLC2B_HUMAN
    Recommended name:
    C-type lectin domain family 2 member B
    Protein Accession:
    Q92478
    Secondary Accessions:
    • B2R9U1
    • Q8IZE9
    • Q9BS74
    • Q9UQB4

    Protein attributes for CLEC2B Gene

    Size:
    149 amino acids
    Molecular mass:
    17307 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC2B Gene

Proteomics data for CLEC2B Gene at MOPED

Post-translational modifications for CLEC2B Gene

  • Glycosylation at Asn57, Asn62, and Asn100
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLEC2B Gene

Domains for CLEC2B Gene

Gene Families for CLEC2B Gene

HGNC:
  • CLEC :C-type lectin domain containing

Protein Domains for CLEC2B Gene

Suggested Antigen Peptide Sequences for CLEC2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92478

UniProtKB/Swiss-Prot:

CLC2B_HUMAN :
  • Q92478
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC2B: view

Function for CLEC2B Gene

Gene Ontology (GO) - Molecular Function for CLEC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC2B: view

Phenotypes for CLEC2B Gene

GenomeRNAi human phenotypes for CLEC2B:
genes like me logo Genes that share phenotypes with CLEC2B: view

Animal Model Products

CRISPR Products

miRNA for CLEC2B Gene

miRTarBase miRNAs that target CLEC2B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC2B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLEC2B Gene

Localization for CLEC2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC2B Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC2B Gene COMPARTMENTS Subcellular localization image for CLEC2B gene
Compartment Confidence
plasma membrane 4
extracellular 3
chloroplast 2
mitochondrion 2
nucleus 2
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CLEC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9038101
genes like me logo Genes that share ontologies with CLEC2B: view

Pathways for CLEC2B Gene

SuperPathways for CLEC2B Gene

No Data Available

Interacting Proteins for CLEC2B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000228438%0d%0a9606.ENSP00000278886%0d%0a9606.ENSP00000452780%0d%0a9606.ENSP00000341390%0d%0a
Selected Interacting proteins: ENSP00000228438 for CLEC2B Gene via STRING

Gene Ontology (GO) - Biological Process for CLEC2B Gene

None

No data available for Pathways by source for CLEC2B Gene

Transcripts for CLEC2B Gene

mRNA/cDNA for CLEC2B Gene

Unigene Clusters for CLEC2B Gene

C-type lectin domain family 2, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC2B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CLEC2B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC2B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP3:
SP4: - - -
SP5:

Relevant External Links for CLEC2B Gene

GeneLoc Exon Structure for
CLEC2B
ECgene alternative splicing isoforms for
CLEC2B

Expression for CLEC2B Gene

mRNA expression in normal human tissues for CLEC2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC2B Gene

This gene is overexpressed in Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLEC2B Gene

SOURCE GeneReport for Unigene cluster for CLEC2B Gene Hs.85201

mRNA Expression by UniProt/SwissProt for CLEC2B Gene

Q92478-CLC2B_HUMAN
Tissue specificity: Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types
genes like me logo Genes that share expressions with CLEC2B: view

In Situ Assay Products

Orthologs for CLEC2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC2B 35
  • 99.78 (n)
  • 100 (a)
CLEC2B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 24 (a)
ManyToMany
CLEC2B 35
  • 72.95 (n)
  • 54.35 (a)
dog
(Canis familiaris)
Mammalia CLEC2B 35
  • 81.82 (n)
  • 70.25 (a)
CLEC2B 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4922502D21Rik 36
  • 14 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 17 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 20 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
Species with no ortholog for CLEC2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC2B Gene

ENSEMBL:
Gene Tree for CLEC2B (if available)
TreeFam:
Gene Tree for CLEC2B (if available)

Paralogs for CLEC2B Gene

Paralogs for CLEC2B Gene

Selected SIMAP similar genes for CLEC2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLEC2B: view

Variants for CLEC2B Gene

Sequence variations from dbSNP and Humsavar for CLEC2B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs14999 -- 9,853,362(-) ATGAT(G/T)GTGCA reference, missense
rs33869 -- 9,855,249(-) TTGAC(C/T)ATAGT intron-variant
rs33870 -- 9,855,264(-) TGGGG(C/T)AGATA intron-variant
rs33871 -- 9,855,298(-) GTATT(A/G)AAATG intron-variant
rs33872 -- 9,855,403(-) TGAAT(A/G)TAGGA intron-variant

Relevant External Links for CLEC2B Gene

HapMap Linkage Disequilibrium report
CLEC2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CLEC2B Gene

Disorders for CLEC2B Gene

Relevant External Links for CLEC2B

Human Genome Epidemiology (HuGE) Navigator
CLEC2B
genes like me logo Genes that share disorders with CLEC2B: view

No data available for UniProtKB/Swiss-Prot for CLEC2B Gene

Publications for CLEC2B Gene

  1. AICL, a new activation induced antigen encoded by the human NK gene complex. (PMID: 9038101) Hamann J. … van Lier R.A.W. (Immunogenetics 1997) 2 3 4 23
  2. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PMID: 10072769) Yokoyama-Kobayashi M. … Kato S. (Gene 1999) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. NKp80 defines and stimulates a reactive subset of CD8 T cells. (PMID: 18922855) Kuttruff S. … Steinle A. (Blood 2009) 3 23
  5. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. (PMID: 20194751) Spreu J. … Steinle A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23

Products for CLEC2B Gene

Sources for CLEC2B Gene

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