Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLEC2B Gene

Aliases for CLEC2B Gene

  • C-Type Lectin Domain Family 2 Member B 2 3 5
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 2 (Activation-Induced) 2 3
  • IFN-Alpha-2b-Inducing-Related Protein 1 3 4
  • C-Type Lectin Superfamily Member 2 3 4
  • Activation-Induced C-Type Lectin 3 4
  • CLECSF2 3 4
  • IFNRG1 3 4
  • AICL 3 4
  • C-Type Lectin Domain Family 2, Member B 2
  • IFN-Alpha2b-Inducing Related Protein 1 3
  • HP10085 3

External Ids for CLEC2B Gene

Previous HGNC Symbols for CLEC2B Gene


Previous GeneCards Identifiers for CLEC2B Gene

  • GC12M009898
  • GC12M010004
  • GC12M009747
  • GC12M009930
  • GC12M010435
  • GC12M010764
  • GC12M010999

Summaries for CLEC2B Gene

Entrez Gene Summary for CLEC2B Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLEC2B Gene

CLEC2B (C-Type Lectin Domain Family 2 Member B) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC2A.

Gene Wiki entry for CLEC2B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC2B Gene

Genomics for CLEC2B Gene

Regulatory Elements for CLEC2B Gene

Enhancers for CLEC2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F010119 1.1 FANTOM5 Ensembl 7.6 -250.5 -250465 3.2 RNF2 MAX CEBPB CEBPG KDM1A NFE2 MYC NFE2L2 CLEC7A CLEC12A CLEC2B CLEC9A OLR1 GABARAPL1 KLRD1 CLEC1B LOC105369655
GH12F008986 1 Ensembl ENCODE 7.5 +880.4 880373 6.3 PKNOX1 ZNF280D MAFF JUN DPF2 BCL6 RAD21 KLRG1 M6PR PHC1 CLEC2B ENSG00000257105
GH12F009646 1.4 FANTOM5 ENCODE 6.1 +218.4 218403 10.0 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 SLC30A9 CBX5 SP3 SP5 CLEC2D LOC374443 KLRB1 CLECL1 CLEC12A ENSG00000214776 PHC1 CD69 CLEC7A DDX12P
GH12F008904 1 FANTOM5 Ensembl 5.6 +965.2 965236 1.0 CLEC6A CLEC4E M6PR CLEC2B CLEC4D PHC1 A2ML1-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CLEC2B on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC2B Gene

9,852,369 bp from pter
9,870,136 bp from pter
17,768 bases
Minus strand

Genomic View for CLEC2B Gene

Genes around CLEC2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC2B Gene

Proteins for CLEC2B Gene

  • Protein details for CLEC2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 2 member B
    Protein Accession:
    Secondary Accessions:
    • B2R9U1
    • Q8IZE9
    • Q9BS74
    • Q9UQB4

    Protein attributes for CLEC2B Gene

    149 amino acids
    Molecular mass:
    17307 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC2B Gene

Post-translational modifications for CLEC2B Gene

  • Glycosylation at Asn 57, Asn 62, and Asn 100
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLEC2B Gene

Domains & Families for CLEC2B Gene

Gene Families for CLEC2B Gene

Protein Domains for CLEC2B Gene

Suggested Antigen Peptide Sequences for CLEC2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC2B: view

Function for CLEC2B Gene

Gene Ontology (GO) - Molecular Function for CLEC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA,TAS --
genes like me logo Genes that share ontologies with CLEC2B: view
genes like me logo Genes that share phenotypes with CLEC2B: view

Animal Model Products

miRNA for CLEC2B Gene

miRTarBase miRNAs that target CLEC2B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC2B Gene

Localization for CLEC2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC2B Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for CLEC2B Gene COMPARTMENTS Subcellular localization image for CLEC2B gene
Compartment Confidence
plasma membrane 5
extracellular 4
chloroplast 2
mitochondrion 2
cytosol 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CLEC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9038101
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC2B: view

Pathways & Interactions for CLEC2B Gene

genes like me logo Genes that share pathways with CLEC2B: view

Interacting Proteins for CLEC2B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000228438 Q92478-CLC2B_HUMAN for CLEC2B Gene via STRING IID

Gene Ontology (GO) - Biological Process for CLEC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CLEC2B: view

No data available for SIGNOR curated interactions for CLEC2B Gene

Transcripts for CLEC2B Gene

Unigene Clusters for CLEC2B Gene

C-type lectin domain family 2, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC2B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP4: - - -

Relevant External Links for CLEC2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLEC2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC2B Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for CLEC2B Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLEC2B Gene

Protein tissue co-expression partners for CLEC2B Gene

NURSA nuclear receptor signaling pathways regulating expression of CLEC2B Gene:


SOURCE GeneReport for Unigene cluster for CLEC2B Gene:


mRNA Expression by UniProt/SwissProt for CLEC2B Gene:

Tissue specificity: Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types.
genes like me logo Genes that share expression patterns with CLEC2B: view

Primer Products

Orthologs for CLEC2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLEC2B 34 35
  • 99.78 (n)
(Canis familiaris)
Mammalia CLEC2B 34 35
  • 81.82 (n)
(Bos Taurus)
Mammalia CLEC2B 34
  • 72.95 (n)
-- 35
  • 24 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 17 (a)
(Mus musculus)
Mammalia 4922502D21Rik 35
  • 14 (a)
(Gallus gallus)
Aves -- 35
  • 20 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 26 (a)
-- 35
  • 23 (a)
-- 35
  • 21 (a)
Species where no ortholog for CLEC2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC2B Gene

Gene Tree for CLEC2B (if available)
Gene Tree for CLEC2B (if available)

Paralogs for CLEC2B Gene

Paralogs for CLEC2B Gene

(20) SIMAP similar genes for CLEC2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLEC2B: view

Variants for CLEC2B Gene

Sequence variations from dbSNP and Humsavar for CLEC2B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10644863 -- 9,869,849(+) GTGAG(-/CACA/CACACA/CACACACA/CACACACACA)CACAC utr-variant-5-prime
rs10649717 -- 9,853,071(+) AAGAA(-/AG)AGAAA utr-variant-3-prime
rs10734816 -- 9,868,863(+) AATTT(A/T)TCATA intron-variant
rs10743867 -- 9,863,050(+) ACTTG(A/G)CCAAA intron-variant
rs10772219 -- 9,866,454(+) CTAGT(A/G)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC2B Gene

Variant ID Type Subtype PubMed ID
nsv1051530 CNV gain 25217958
nsv951325 CNV duplication 24416366

Variation tolerance for CLEC2B Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC2B Gene

Disorders for CLEC2B Gene

Relevant External Links for CLEC2B

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLEC2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC2B Gene

Publications for CLEC2B Gene

  1. AICL, a new activation induced antigen encoded by the human NK gene complex. (PMID: 9038101) Hamann J. … van Lier R.A.W. (Immunogenetics 1997) 2 3 4 22 64
  2. NKp80 defines and stimulates a reactive subset of CD8 T cells. (PMID: 18922855) Kuttruff S. … Steinle A. (Blood 2009) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PMID: 10072769) Yokoyama-Kobayashi M. … Kato S. (Gene 1999) 3 4 64
  5. C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets. (PMID: 25462818) Manne B.K. … Kunapuli S.P. (Biochem. Pharmacol. 2015) 3 64

Products for CLEC2B Gene

Sources for CLEC2B Gene

Loading form....