Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLEC2B Gene

Aliases for CLEC2B Gene

  • C-Type Lectin Domain Family 2 Member B 2 3 5
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 2 (Activation-Induced) 2 3
  • C-Type Lectin Domain Family 2, Member B 2 3
  • IFN-Alpha-2b-Inducing-Related Protein 1 3 4
  • C-Type Lectin Superfamily Member 2 3 4
  • Activation-Induced C-Type Lectin 3 4
  • CLECSF2 3 4
  • IFNRG1 3 4
  • AICL 3 4
  • IFN-Alpha2b-Inducing Related Protein 1 3
  • HP10085 3

External Ids for CLEC2B Gene

Previous HGNC Symbols for CLEC2B Gene


Previous GeneCards Identifiers for CLEC2B Gene

  • GC12M009898
  • GC12M010004
  • GC12M009747
  • GC12M009930
  • GC12M010435

Summaries for CLEC2B Gene

Entrez Gene Summary for CLEC2B Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLEC2B Gene

CLEC2B (C-Type Lectin Domain Family 2 Member B) is a Protein Coding gene. Diseases associated with CLEC2B include Lown-Ganong-Levine Syndrome and Partial Optic Atrophy. Among its related pathways are Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions and Immune System. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC2L.

Gene Wiki entry for CLEC2B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC2B Gene

Genomics for CLEC2B Gene

Regulatory Elements for CLEC2B Gene

Enhancers for CLEC2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLEC2B on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC2B Gene

9,852,369 bp from pter
9,870,136 bp from pter
17,768 bases
Minus strand

Genomic View for CLEC2B Gene

Genes around CLEC2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC2B Gene

Proteins for CLEC2B Gene

  • Protein details for CLEC2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 2 member B
    Protein Accession:
    Secondary Accessions:
    • B2R9U1
    • Q8IZE9
    • Q9BS74
    • Q9UQB4

    Protein attributes for CLEC2B Gene

    149 amino acids
    Molecular mass:
    17307 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC2B Gene

Proteomics data for CLEC2B Gene at MOPED

Post-translational modifications for CLEC2B Gene

  • Glycosylation at Asn 57, Asn 62, and Asn 100
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLEC2B Gene

Domains & Families for CLEC2B Gene

Gene Families for CLEC2B Gene

Protein Domains for CLEC2B Gene

Suggested Antigen Peptide Sequences for CLEC2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC2B: view

Function for CLEC2B Gene

genes like me logo Genes that share phenotypes with CLEC2B: view

Animal Model Products

CRISPR Products

miRNA for CLEC2B Gene

miRTarBase miRNAs that target CLEC2B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC2B Gene

Localization for CLEC2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC2B Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for CLEC2B Gene COMPARTMENTS Subcellular localization image for CLEC2B gene
Compartment Confidence
plasma membrane 5
extracellular 4
chloroplast 2
mitochondrion 2
cytosol 1
golgi apparatus 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CLEC2B Gene

Pathways & Interactions for CLEC2B Gene

genes like me logo Genes that share pathways with CLEC2B: view

Interacting Proteins for CLEC2B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000228438 for CLEC2B Gene via STRING

Gene Ontology (GO) - Biological Process for CLEC2B Gene


No data available for SIGNOR curated interactions for CLEC2B Gene

Drugs & Compounds for CLEC2B Gene

No Compound Related Data Available

Transcripts for CLEC2B Gene

Unigene Clusters for CLEC2B Gene

C-type lectin domain family 2, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC2B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP4: - - -

Relevant External Links for CLEC2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC2B Gene

mRNA expression in normal human tissues for CLEC2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC2B Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for CLEC2B Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLEC2B Gene

SOURCE GeneReport for Unigene cluster for CLEC2B Gene Hs.85201

mRNA Expression by UniProt/SwissProt for CLEC2B Gene

Tissue specificity: Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types.
genes like me logo Genes that share expression patterns with CLEC2B: view

Protein tissue co-expression partners for CLEC2B Gene

Primer Products

Orthologs for CLEC2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLEC2B 35
  • 72.95 (n)
  • 54.35 (a)
-- 36
  • 24 (a)
(Canis familiaris)
Mammalia CLEC2B 35
  • 81.82 (n)
  • 70.25 (a)
  • 52 (a)
(Pan troglodytes)
Mammalia CLEC2B 35
  • 99.78 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia 4922502D21Rik 36
  • 14 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 17 (a)
(Gallus gallus)
Aves -- 36
  • 20 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
-- 36
  • 21 (a)
-- 36
  • 23 (a)
Species with no ortholog for CLEC2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC2B Gene

Gene Tree for CLEC2B (if available)
Gene Tree for CLEC2B (if available)

Paralogs for CLEC2B Gene

Paralogs for CLEC2B Gene

(20) SIMAP similar genes for CLEC2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLEC2B: view

Variants for CLEC2B Gene

Sequence variations from dbSNP and Humsavar for CLEC2B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs14999 -- 9,853,362(-) ATGAT(G/T)GTGCA reference, missense
rs33869 -- 9,855,249(-) TTGAC(C/T)ATAGT intron-variant
rs33870 -- 9,855,264(-) TGGGG(C/T)AGATA intron-variant
rs33871 -- 9,855,298(-) GTATT(A/G)AAATG intron-variant
rs33872 -- 9,855,403(-) TGAAT(A/G)TAGGA intron-variant

Variation tolerance for CLEC2B Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CLEC2B Gene

Disorders for CLEC2B Gene

MalaCards: The human disease database

(4) MalaCards diseases for CLEC2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
lown-ganong-levine syndrome
  • atrial tachyarrhythmia with short pr interval
partial optic atrophy
methylmalonic aciduria and homocystinuria, cblc type
  • methylmalonic aciduria and homocystinuria type cblc
mesenteric lymphadenitis
  • mesenteric adenitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CLEC2B

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CLEC2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLEC2B Gene

Publications for CLEC2B Gene

  1. AICL, a new activation induced antigen encoded by the human NK gene complex. (PMID: 9038101) Hamann J. … van Lier R.A.W. (Immunogenetics 1997) 2 3 4 23 67
  2. NKp80 defines and stimulates a reactive subset of CD8 T cells. (PMID: 18922855) Kuttruff S. … Steinle A. (Blood 2009) 3 23
  3. C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets. (PMID: 25462818) Manne B.K. … Kunapuli S.P. (Biochem. Pharmacol. 2015) 3
  4. Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses. (PMID: 23929856) Klimosch S.N. … Steinle A. (Blood 2013) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for CLEC2B Gene

Sources for CLEC2B Gene