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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC2B Gene

protein-coding   GIFtS: 51
GCID: GC12M010004

C-type lectin domain family 2, member B

(Previous names: C-type (calcium dependent, carbohydrate-recognition domain)...)
(Previous symbol: CLECSF2)
 Explore 6 diseases affiliated with
CLEC2B via our new
 Human Malady Compendium 
Biological research products
for CLEC2B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 2, Member B1 2     IFNRG12 3
AICL1 2 3 5     C-Type Lectin Superfamily Member 22 3
CLECSF21 2 3 5     IFN-Alpha-2b-Inducing-Related Protein 12 3
HP100851 2     C-Type Lectin Domain Family 2 Member B2
C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily
Member 2 (Activation-Induced)1 2
     IFN-Alpha2b-Inducing Related Protein 12
Activation-Induced C-Type Lectin2 3     

External Ids:    HGNC: 20531   Entrez Gene: 99762   Ensembl: ENSG000001108527   OMIM: 6032425   UniProtKB: Q924783   

Export aliases for CLEC2B gene to outside databases

Previous GC identifers: GC12M009898 GC12M009747


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLEC2B:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this
family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling,
glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may
function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence
has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the
natural killer gene complex region. (provided by RefSeq, Jul 2008)

Gene Wiki entry for CLEC2B


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CLEC2B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC2B promoter sequence
   Search SABiosciences Chromatin IP Primers for CLEC2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13-p12   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13-p12

CLEC2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC2B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010004:  view genomic region     (about GC identifiers)

Start:
10,004,968 bp from pter      End:
10,022,735 bp from pter
Size:
17,768 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLC2B_HUMAN, Q92478 (See protein sequence)
Recommended Name: C-type lectin domain family 2 member B  
Size: 149 amino acids; 17307 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Probable)
Secondary accessions: B2R9U1 Q8IZE9 Q9BS74 Q9UQB4

Explore the universe of human proteins at neXtProt for CLEC2B: NX_Q92478

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92478

  • CLEC2B Protein expression data from MOPED and PaxDb:    About this image 
    CLEC2B Protein Expression
    REFSEQ proteins: NP_005118.2  
    ENSEMBL proteins: 
     ENSP00000228438   ENSP00000437946  

    Human Recombinant Protein Products for CLEC2B: 
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    Uscn Proteins for CLEC2B

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS9038101

    CLEC2B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLEC2B


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CLEC2B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q92478

    ProtoNet protein and cluster: Q92478

    1 Blocks protein family: IPB001917 Aminotransferase

    UniProtKB/Swiss-Prot: CLC2B_HUMAN, Q92478
    Similarity: Contains 1 C-type lectin domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding IEA--
         
    CLEC2B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CLEC2B:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CLEC2B 

    miRNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC2B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC2B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CLEC2B (ENSP000002284384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NINLENSP000002788864STRING: ENSP00000278886
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLEC2B
    Search CenterWatch for drugs/clinical trials and news about CLEC2B / CLC2B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLEC2B gene: 
    NM_005127.2  

    Unigene Cluster for CLEC2B:

    C-type lectin domain family 2, member B
    Hs.85201  [show with all ESTs]
    Unigene Representative Sequence: NM_005127
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228438(uc001qwn.3) ENST00000538152 ENST00000540743 ENST00000539028


    miRNA
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    Inhib. RNA
    Products:
         
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    OriGene shRNA RFP: CLEC2B
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC2B
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    Additional cDNA sequence: 

    AB015628.1 AK307334.1 AK311232.1 AK313916.1 AY142147.1 BC005254.1 BC035924.1 X96719.1 

    9 DOTS entries:

    DT.213213  DT.92432694  DT.75102270  DT.121123175  DT.92432696  DT.100813985  DT.92432695  DT.92030371 
    DT.75180023 

    24/133 AceView cDNA sequences (see all 133):

    AI253745 AI242291 AI886766 BM711464 BI963087 BQ012758 CR604988 BM469192 
    NM_005127 AB015628 AA418172 BX279662 BC035924 AA749323 BQ774467 BG503026 
    T46996 BI962926 CA447397 BM670715 AI074659 BE173196 BC005254 BQ003727 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC2B    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c
    SP1:                                      -     -                                 
    SP2:                                      -     -     -                           
    SP3:                                                                              
    SP4:                          -           -     -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for CLEC2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLEC2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAGGGAGTG
    CLEC2B Expression
    About this image
    See CLEC2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLEC2B

    SOURCE GeneReport for Unigene cluster: Hs.85201

    UniProtKB/Swiss-Prot: CLC2B_HUMAN, Q92478
    Tissue specificity: Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types

        SABiosciences Custom PCR Arrays for CLEC2B
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC2B gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CLEC2B6
    --
    (see all 13)
    --
    39(a)
    35(a)
    (see all 13)
    1 ↔ many
    1 ↔ many
    (see all 13)
    16(287484-288337)
    16(88452-89368)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    --
    59(a)
    51(a)
    (see all 8)
    1 ↔ many
    1 ↔ many
    (see all 8)
    GL343316.1(18858-20940)
    GL344089.1(7089-12704)


    ENSEMBL Gene Tree for CLEC2B (if available)
    TreeFam Gene Tree for CLEC2B (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLEC2B gene
    CLEC2L2  CLEC2A2  KLRF22  KLRG22  CD692  CLEC2D2  CLEC5A2  KLRF12  
    KLRG12  KLRB12  
    18/22 SIMAP similar genes for CLEC2B using alignment to 2 protein entries:     CLC2B_HUMAN (see all proteins) (see all similar genes):
    CLEC2D    CLEC2A    KLRD1    CLEC9A    KLRB1    CLEC2L
    CLEC4C    KLRF1    KLRC2    KLRG1    CD69    CD209
    CLEC12A    CLEC4G    CLEC4M    KLRK1    CLEC12B    CLEC17A

    CLEC2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/330 NCBI SNPs in CLEC2B are shown (see all 330    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425539791,2
    --10004519(+) GTCCTC/TCCTAA 1 -- ds50010--------
    rs79736291,2
    C,F--10004538(+) CTTCCA/CAGCAG 1 -- ds50016Minor allele frequency- C:0.15NA WA EA 364
    rs29087001,2
    C,F,O,H--10004648(-) CTGGTA/GAATCT 1 -- ds500117Minor allele frequency- N:0.00EA NA NS WA CSA 994
    rs1912780611,2
    --10004885(+) AATGCA/GAGGAC 1 -- ds50010--------
    rs792386501,2
    C,F--10004891(+) AGGACC/TAGGGG 1 -- ds50011Minor allele frequency- T:0.07WA 118
    rs1466608861,2
    --10004907(+) TGGTTC/TGTCTA 1 -- ds50010--------
    rs29086991,2
    C,F,H--10004932(-) CATCTC/TCAACC 1 -- ds50017Minor allele frequency- T:0.05NS EA WA NA 764
    rs1830684011,2
    --10004949(+) AAAAAA/CAACAA 1 -- ds50010--------
    rs1859893431,2
    --10004990(+) GTTTAC/TTGGCC 1 -- ut310--------
    rs1475905901,2
    --10005199(+) CCTGGC/TCTGTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLEC2B (10004968 - 10022735 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLEC2B: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC2B
    DNA2.0 Custom Variant and Variant Library Synthesis for CLEC2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CLEC2B for disorders           About GeneDecksing

    OMIM gene information: 603242    OMIM disorders: --

    6 diseases for CLEC2B:    About MalaCards
    lown-ganong-levine syndrome    botulism    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    hepatitis b    hepatitis

    1 disease from the University of Copenhagen DISEASES database for CLEC2B:
    Methylmalonic acidemia
    Human Genome Epidemiology (HuGE) Navigator: CLEC2B (2 documents)

    Export disorders for CLEC2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLEC2B gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with CLEC2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AICL, a new activation induced antigen encoded by the human NK gene complex. (PubMed id 9038101)1, 2, 3, 9 Hamann J.... van Lier R.A.W. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PubMed id 10072769)1, 2 Yokoyama-Kobayashi M.... Kato S. (1999)
    4. NKp80 defines and stimulates a reactive subset of CD8 T cells. (PubMed id 18922855)1, 9 Kuttruff S....Steinle A. (2009)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    7. Tumor cells of non-hematopoietic and hematopoietic or igins express activation-induced C-type lectin, the ligand for killer cell lect in-like receptor F1. (PubMed id 20663776)1 Akatsuka A....Matsumoto N. (2010)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9976 HGNC: 2053 AceView: CLECSF2 Ensembl:ENSG00000110852 euGenes: HUgn9976
    ECgene: CLEC2B H-InvDB: CLEC2B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLEC2B Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_236

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLEC2B gene:
    Search GeneIP for patents involving CLEC2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     CLEC2B Proteins, Antibodies, CLIAs, and ELISAs
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    Sirion Biotech Customized:
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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