Aliases for CLEC2A Gene
External Ids for CLEC2A Gene
Previous GeneCards Identifiers for CLEC2A Gene
CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008]
GeneCards Summary for CLEC2A Gene
CLEC2A (C-Type Lectin Domain Family 2 Member A) is a Protein Coding gene. Diseases associated with CLEC2A include eccrine sweat gland neoplasm and pilar sheath acanthoma. GO annotations related to this gene include protein homodimerization activity and carbohydrate binding. An important paralog of this gene is CLEC2L.
UniProtKB/Swiss-Prot for CLEC2A Gene
Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.