CLEC2A Gene
protein-coding GIFtS: 37
GCID: GC12M010051
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C-type lectin domain family 2, member A
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Aliases
for CLEC2A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| C-Type Lectin Domain Family 2, Member A1 2 | | UNQ57921 2 | | KACL1 2 3 | | Keratinocyte-Associated C-Type Lectin2 3 | | PILAR1 2 3 | | Proliferation-Induced Lymphocyte-Associated Receptor2 3 | | INPE57921 2 | | C-Type Lectin Domain Family 2 Member A2 |
Export aliases for CLEC2A gene to outside databasesPrevious GC identifers: GC12M009943 GC12U901034 GC12M009808 |
Summaries
for CLEC2A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CLEC2A:
CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-likereceptors (Spreu et al., 2007 (PubMed 18046548)).(supplied by OMIM, May 2008)
UniProtKB/Swiss-Prot: CLC2A_HUMAN, Q6UVW9Function: Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cellsby increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity ofT-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interactionwith its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity
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Genomic Views
for CLEC2A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLEC2A gene promoter:
ISGF-3 AP-1 HNF-1A FOXL1 Evi-1 POU2F1 FOXJ2 (long isoform) HNF-1 POU2F1a FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLEC2A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC2A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31CLEC2A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M010051: view genomic region
(about GC identifiers)
Start:
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10,051,272 bp from pter |
End:
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10,084,980 bp from pter |
Size:
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33,709 bases |
Orientation:
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minus strand |
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Proteins
for CLEC2A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLC2A_HUMAN, Q6UVW9 (See
protein sequence)Recommended Name: C-type lectin domain family 2 member A Size: 174 amino acids; 19972 Da
Subunit: Homodimer; non disulfide-linked. Interacts with KLRB1. Interacts with KLRF2
Subcellular location: Cell membrane; Single-pass type II membrane protein
Secondary accessions: A5Y4G5 A9QKS2 A9QKS3Alternative splicing: 2 isoforms: Q6UVW9-1 Q6UVW9-2 Explore the universe of human proteins at neXtProt for CLEC2A: NX_Q6UVW9
Post-translational modifications:
N-glycosylated1
View neXtProt modification sites for NX_Q6UVW9
CLEC2A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001124183.1
ENSEMBL proteins: ENSP00000339732 ENSP00000396163
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
CLEC2A for ontologies About GeneDecksing
CLEC2A Antibody Products:
Assay Products for CLEC2A: |
Protein
Domains /
Families
for CLEC2A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLEC2A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UVW9ProtoNet protein and cluster: Q6UVW9 UniProtKB/Swiss-Prot: CLC2A_HUMAN, Q6UVW9Similarity: Contains 1 C-type lectin domain |
Function
for CLEC2A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CLC2A_HUMAN, Q6UVW9Function: Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cellsby increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity ofT-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interactionwith its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicityInduction: By phytohemagglutinin (PHA) in peripheral CD8(+) T cells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC2A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC2A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for CLEC2A | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLEC2A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC2A |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CLEC2A for ontologies About GeneDecksing
|
Pathways & Interactions
for CLEC2A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC2A
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042267 | natural killer cell mediated cytotoxicity |
TAS | -- |
CLEC2A for ontologies About GeneDecksing
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Drugs & Compounds
for CLEC2A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CLEC2A
Search CenterWatch for drugs/clinical trials and news about CLEC2A / CLC2A
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Transcripts
for CLEC2A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLEC2A gene (2 alternative transcripts): NM_001130711.1 NM_207375.1 Unigene Cluster for CLEC2A: C-type lectin domain family 2, member A Hs.527665 Unigene Representative Sequence: EF1274672 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000339766(uc009zhb.2) ENST00000455827(uc009zhc.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC2A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC2A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CLEC2A (NM_001130711) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLEC2A | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLEC2A |
Additional cDNA sequence: AY359126.1 EF127467.1 EU095393.1 EU095394.1 2 AceView cDNA sequences: AY359126 NM_207375
GeneLoc Exon Structure
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Expression
for CLEC2A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLEC2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATTTTTGA
About this image
See CLEC2A Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.527665
UniProtKB/Swiss-Prot: CLC2A_HUMAN, Q6UVW9Tissue specificity: Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine,peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naiveCD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer(NK) cells
SABiosciences Custom PCR Arrays for CLEC2A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC2A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CLEC2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC2A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC2A |
Orthologs
for CLEC2A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CLEC2A gene from 1/7 species (see all 7) About this table
Species with no ortholog for CLEC2A
ENSEMBL Gene Tree for CLEC2A (if available)
TreeFam Gene Tree for CLEC2A (if available) |
Paralogs
for CLEC2A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLEC2A gene
- CLEC2L2 CLEC2B2 KLRF22 KLRG22 CD692 CLEC2D2 CLEC5A2 KLRF12
- KLRG12 KLRB12
4 SIMAP similar genes for CLEC2A using alignment to 1 protein entry: CLC2A_HUMAN:CD69 CLEC2D CLEC2B CLEC2L
CLEC2A for paralogs About GeneDecksing
|
Genomic Variants
for CLEC2A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLEC2A (10051272 - 10084980 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLEC2A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC2A |
|
Disorders
/ Diseases
for CLEC2A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLEC2A for disorders About GeneDecksing
OMIM gene information: 612087
OMIM disorders: --
8  diseases for CLEC2A: About MalaCardssyringoma malignant syringoma pilomatrixoma acanthoma
nevus keratosis alopecia leiomyoma
Export disorders for CLEC2A gene to outside databases
|
Publications
for CLEC2A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLEC2A gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLEC2A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. (PubMed id 20194751)1, 2 Spreu J....Steinle A. (2010)
- PILAR is a novel modulator of human T cell expansion. (PubMed id 18550855)1, 2 Huarte E....Conejo-Garcia J.R. (2008)
- CLEC2A: a novel, alternatively spliced and skin-associated member of the NKC-encoded AICL-CD69-LLT1 family. (PubMed id 18046548)1, 2 Spreu J.... Steinle A. (2007)
- Novel interactions in platelet biology: CLEC-2/podopl anin and laminin/GPVI. (PubMed id 19630798)1 Ozaki Y....Inoue O. (2009)
|
External Searches for CLEC2A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CLEC2A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLEC2A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLEC2A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLEC2A | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CLEC2A gene:
Search GeneIP for patents involving CLEC2A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLEC2A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLEC2A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC2A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC2A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLEC2A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC2A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC2A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLEC2A | | OriGene Custom Protein Services for CLEC2A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLEC2A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC2A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC2A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC2A |
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| | | | Search Tocris compounds for CLEC2A |
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 | | | CLEC2A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC2A |
|  |  |  | | | | ThermoFisher Antibodies for CLEC2A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLEC2A |
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