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Aliases for CLEC2A Gene

Aliases for CLEC2A Gene

  • C-Type Lectin Domain Family 2, Member A 2 3
  • Proliferation-Induced Lymphocyte-Associated Receptor 2 3 4
  • Keratinocyte-Associated C-Type Lectin 2 3 4
  • PILAR 3 4
  • KACL 3 4
  • C-Type Lectin Domain Family 2 Member A 3
  • INPE5792 3
  • UNQ5792 3

External Ids for CLEC2A Gene

Previous GeneCards Identifiers for CLEC2A Gene

  • GC12M009943
  • GC12U901034
  • GC12M010051
  • GC12M009808

Summaries for CLEC2A Gene

Entrez Gene Summary for CLEC2A Gene

  • CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008]

GeneCards Summary for CLEC2A Gene

CLEC2A (C-Type Lectin Domain Family 2, Member A) is a Protein Coding gene. Diseases associated with CLEC2A include leiomyoma cutis and epidermal appendage tumor. GO annotations related to this gene include protein homodimerization activity and carbohydrate binding. An important paralog of this gene is CLEC2L.

UniProtKB/Swiss-Prot for CLEC2A Gene

  • Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC2A Gene

Genomics for CLEC2A Gene

Regulatory Elements for CLEC2A Gene

Genomic Location for CLEC2A Gene

Start:
9,898,673 bp from pter
End:
9,932,381 bp from pter
Size:
33,709 bases
Orientation:
Minus strand

Genomic View for CLEC2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC2A Gene

Proteins for CLEC2A Gene

  • Protein details for CLEC2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UVW9-CLC2A_HUMAN
    Recommended name:
    C-type lectin domain family 2 member A
    Protein Accession:
    Q6UVW9
    Secondary Accessions:
    • A5Y4G5
    • A9QKS2
    • A9QKS3

    Protein attributes for CLEC2A Gene

    Size:
    174 amino acids
    Molecular mass:
    19972 Da
    Quaternary structure:
    • Homodimer; non disulfide-linked. Interacts with KLRB1. Interacts with KLRF2.

    Three dimensional structures from OCA and Proteopedia for CLEC2A Gene

    Alternative splice isoforms for CLEC2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC2A Gene

Proteomics data for CLEC2A Gene at MOPED

Post-translational modifications for CLEC2A Gene

Other Protein References for CLEC2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CLEC2A Gene

Domains for CLEC2A Gene

Gene Families for CLEC2A Gene

HGNC:
  • CLEC :C-type lectin domain containing

Protein Domains for CLEC2A Gene

Suggested Antigen Peptide Sequences for CLEC2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UVW9

UniProtKB/Swiss-Prot:

CLC2A_HUMAN :
  • Q6UVW9
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC2A: view

Function for CLEC2A Gene

Molecular function for CLEC2A Gene

UniProtKB/Swiss-Prot Function: Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.
UniProtKB/Swiss-Prot Induction: By phytohemagglutinin (PHA) in peripheral CD8(+) T cells

Gene Ontology (GO) - Molecular Function for CLEC2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20194751
GO:0030246 carbohydrate binding IEA --
GO:0042803 protein homodimerization activity IDA 20194751
genes like me logo Genes that share ontologies with CLEC2A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLEC2A Gene

Localization for CLEC2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC2A Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC2A Gene COMPARTMENTS Subcellular localization image for CLEC2A gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CLEC2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC2A: view

Pathways for CLEC2A Gene

SuperPathways for CLEC2A Gene

No Data Available

Interacting Proteins for CLEC2A Gene

Gene Ontology (GO) - Biological Process for CLEC2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042267 natural killer cell mediated cytotoxicity TAS 20194751
genes like me logo Genes that share ontologies with CLEC2A: view

No data available for Pathways by source for CLEC2A Gene

Transcripts for CLEC2A Gene

mRNA/cDNA for CLEC2A Gene

(6) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC2A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CLEC2A
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC2A Gene

No ASD Table

Relevant External Links for CLEC2A Gene

GeneLoc Exon Structure for
CLEC2A
ECgene alternative splicing isoforms for
CLEC2A

Expression for CLEC2A Gene

mRNA expression in normal human tissues for CLEC2A Gene

mRNA differential expression in normal tissues according to GTEx for CLEC2A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (28.1) and Skin - Not Sun Exposed (Suprapubic) (21.2).

SOURCE GeneReport for Unigene cluster for CLEC2A Gene Hs.527665

mRNA Expression by UniProt/SwissProt for CLEC2A Gene

Q6UVW9-CLC2A_HUMAN
Tissue specificity: Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.
genes like me logo Genes that share expressions with CLEC2A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for CLEC2A Gene

Orthologs for CLEC2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC2A 35
  • 99.43 (n)
  • 98.85 (a)
CLEC2A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLEC2A 35
  • 77.19 (n)
  • 65.13 (a)
CLEC2A 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 26 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Clec2f 35
  • 53.47 (n)
  • 40.97 (a)
Clec2i 36
  • 29 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 17 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for CLEC2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC2A Gene

ENSEMBL:
Gene Tree for CLEC2A (if available)
TreeFam:
Gene Tree for CLEC2A (if available)

Paralogs for CLEC2A Gene

Paralogs for CLEC2A Gene

Selected SIMAP similar genes for CLEC2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLEC2A: view

Variants for CLEC2A Gene

Sequence variations from dbSNP and Humsavar for CLEC2A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs486729 -- 9,902,899(-) TAGAA(A/G)GTTTA intron-variant
rs486890 -- 9,917,748(+) TCTCT(A/G)CAACC intron-variant
rs499538 -- 9,921,949(+) ccaca(C/T)agttc intron-variant
rs519802 -- 9,919,012(+) ttgga(C/G)gtatt intron-variant
rs523385 -- 9,928,866(+) atagg(A/G)gaacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC2A Gene

Variant ID Type Subtype PubMed ID
nsv523050 CNV Loss 19592680
nsv898755 CNV Loss 21882294

Relevant External Links for CLEC2A Gene

HapMap Linkage Disequilibrium report
CLEC2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC2A Gene

Disorders for CLEC2A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (8) Diseases for CLEC2A Gene including...

Search for CLEC2A Gene in MalaCards »
genes like me logo Genes that share disorders with CLEC2A: view

No data available for UniProtKB/Swiss-Prot for CLEC2A Gene

Publications for CLEC2A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. CLEC2A: a novel, alternatively spliced and skin-associated member of the NKC-encoded AICL-CD69-LLT1 family. (PMID: 18046548) Spreu J. … Steinle A. (Immunogenetics 2007) 3 4
  3. PILAR is a novel modulator of human T-cell expansion. (PMID: 18550855) Huarte E. … Conejo-Garcia J.R. (Blood 2008) 3 4
  4. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. (PMID: 20194751) Spreu J. … Steinle A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4
  5. CLEC-2 expression is maintained on activated platelets and on platelet microparticles. (PMID: 25150298) Gitz E. … Watson S.P. (Blood 2014) 3

Products for CLEC2A Gene

Sources for CLEC2A Gene

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