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Aliases for CLEC1B Gene

Aliases for CLEC1B Gene

  • C-Type Lectin Domain Family 1, Member B 2 3
  • CLEC2 3 4 6
  • C-Type Lectin-Like Receptor 2 3 4
  • CLEC2B 3 6
  • CLEC-2 3 4
  • C-Type Lectin Domain Family 1 Member B 3
  • C-Type Lectin-Like Receptor-2 3
  • 1810061I13Rik 3
  • PRO1384 3
  • QDED721 3

External Ids for CLEC1B Gene

Previous GeneCards Identifiers for CLEC1B Gene

  • GC12M010037
  • GC12M010145
  • GC12M009888
  • GC12M010147
  • GC12M010260
  • GC12M010502

Summaries for CLEC1B Gene

Entrez Gene Summary for CLEC1B Gene

  • Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]

GeneCards Summary for CLEC1B Gene

CLEC1B (C-Type Lectin Domain Family 1, Member B) is a Protein Coding gene. Diseases associated with CLEC1B include thrombocytopenia due to platelet alloimmunization. GO annotations related to this gene include carbohydrate binding and transmembrane signaling receptor activity. An important paralog of this gene is CLEC7A.

Gene Wiki entry for CLEC1B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC1B Gene

Genomics for CLEC1B Gene

Regulatory Elements for CLEC1B Gene

Genomic Location for CLEC1B Gene

9,985,642 bp from pter
10,013,424 bp from pter
27,783 bases
Minus strand

Genomic View for CLEC1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC1B Gene

Proteins for CLEC1B Gene

  • Protein details for CLEC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 1 member B
    Protein Accession:
    Secondary Accessions:
    • Q6UWX7
    • Q8NHR6

    Protein attributes for CLEC1B Gene

    229 amino acids
    Molecular mass:
    26596 Da
    Quaternary structure:
    • Homodimer. Interacts (via cytoplasmic domain) with GNB2L1/RACK1; promotes CLEC1B ubiquitination and proteasome-mediated degradation. Interacts (dimer) with SYK (via SH2 domains).
    • Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2 (PubMed:16174766). Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).

    Three dimensional structures from OCA and Proteopedia for CLEC1B Gene

    Alternative splice isoforms for CLEC1B Gene


neXtProt entry for CLEC1B Gene

Proteomics data for CLEC1B Gene at MOPED

Post-translational modifications for CLEC1B Gene

Other Protein References for CLEC1B Gene

Antibody Products

No data available for DME Specific Peptides for CLEC1B Gene

Domains for CLEC1B Gene

Gene Families for CLEC1B Gene

Protein Domains for CLEC1B Gene

Suggested Antigen Peptide Sequences for CLEC1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC1B: view

Function for CLEC1B Gene

Gene Ontology (GO) - Molecular Function for CLEC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10671229
GO:0005515 protein binding IPI 19785988
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC1B: view
genes like me logo Genes that share phenotypes with CLEC1B: view

Animal Models for CLEC1B Gene

MGI Knock Outs for CLEC1B:

Animal Model Products

miRNA for CLEC1B Gene

miRTarBase miRNAs that target CLEC1B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC1B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CLEC1B Gene

Localization for CLEC1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC1B Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for CLEC1B Gene COMPARTMENTS Subcellular localization image for CLEC1B gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CLEC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with CLEC1B: view

Pathways for CLEC1B Gene

SuperPathways for CLEC1B Gene

No Data Available

Interacting Proteins for CLEC1B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9P126-CLC1B_HUMAN ENSP00000298527 for CLEC1B Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for CLEC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 10671229
GO:0007166 cell surface receptor signaling pathway TAS 10671229
GO:0030220 platelet formation IEA --
genes like me logo Genes that share ontologies with CLEC1B: view

No data available for Pathways by source for CLEC1B Gene

Transcripts for CLEC1B Gene

mRNA/cDNA for CLEC1B Gene

Unigene Clusters for CLEC1B Gene

C-type lectin domain family 1, member B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC1B Gene

No ASD Table

Relevant External Links for CLEC1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC1B Gene

mRNA expression in normal human tissues for CLEC1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC1B Gene

This gene is overexpressed in Liver (22.4) and Whole Blood (17.8).

Protein differential expression in normal tissues for CLEC1B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (37.9) and Platelet (30.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLEC1B Gene

SOURCE GeneReport for Unigene cluster for CLEC1B Gene Hs.409794

mRNA Expression by UniProt/SwissProt for CLEC1B Gene

Tissue specificity: Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.
genes like me logo Genes that share expressions with CLEC1B: view

Expression partners for CLEC1B Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for CLEC1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC1B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLEC1B 35
  • 78.81 (n)
  • 69.33 (a)
  • 55 (a)
(Mus musculus)
Mammalia Clec1b 35
  • 75.52 (n)
  • 64.6 (a)
Clec1b 16
Clec1b 36
  • 63 (a)
(Pan troglodytes)
Mammalia CLEC1B 35
  • 98.25 (n)
  • 96.51 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Clec1b 35
  • 74.19 (n)
  • 60.18 (a)
(Canis familiaris)
Mammalia CLEC1B 36
  • 58 (a)
(Monodelphis domestica)
Mammalia CLEC1B 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia CLEC1B 36
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
Species with no ortholog for CLEC1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC1B Gene

Gene Tree for CLEC1B (if available)
Gene Tree for CLEC1B (if available)

Paralogs for CLEC1B Gene

Paralogs for CLEC1B Gene

(11) SIMAP similar genes for CLEC1B Gene using alignment to 2 proteins: Pseudogenes for CLEC1B Gene

genes like me logo Genes that share paralogs with CLEC1B: view

Variants for CLEC1B Gene

Sequence variations from dbSNP and Humsavar for CLEC1B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs476564 -- 9,997,845(-) AGTTA(C/T)TGTGC intron-variant
rs477658 -- 9,998,015(-) TCCAA(A/T)CTATT intron-variant
rs564844 -- 10,000,593(-) AGAAA(C/T)ACAGC upstream-variant-2KB, intron-variant
rs581949 -- 9,996,807(+) TCTCT(C/T)CCTTG intron-variant
rs582968 -- 9,997,058(-) ATGTG(A/G)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC1B Gene

Variant ID Type Subtype PubMed ID
nsv898755 CNV Loss 21882294
nsv525593 CNV Loss 19592680
nsv898756 CNV Loss 21882294
nsv604 CNV Loss 18451855
esv9698 OTHER Inversion 19470904

Relevant External Links for CLEC1B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC1B Gene

Disorders for CLEC1B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CLEC1B Gene in MalaCards »

(1) Disease for CLEC1B Gene

(1) University of Copenhagen DISEASES for CLEC1B Gene

Relevant External Links for CLEC1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CLEC1B: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CLEC1B Gene

Publications for CLEC1B Gene

  1. Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. (PMID: 10671229) Colonna M. … Angman L. (Eur. J. Immunol. 2000) 2 3 4 23
  2. A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. (PMID: 11745369) Sobanov Y. … Hofer E. (Eur. J. Immunol. 2001) 2 3 23
  3. DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. (PMID: 16940507) Chaipan C. … Poehlmann S. (J. Virol. 2006) 3 4 23
  4. Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. (PMID: 17616532) Suzuki-Inoue K. … Ozaki Y. (J. Biol. Chem. 2007) 3 23
  5. Renal cells activate the platelet receptor CLEC-2 through podoplanin. (PMID: 18215137) Christou C.M. … O'Callaghan C.A. (Biochem. J. 2008) 3 23

Products for CLEC1B Gene

Sources for CLEC1B Gene

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