Aliases for CLEC1B Gene
Aliases for CLEC1B Gene
External Ids for CLEC1B Gene
- HGNC: 24356
- Entrez Gene: 51266
- Ensembl: ENSG00000165682
- OMIM: 606783
- UniProtKB: Q9P126
Previous GeneCards Identifiers for CLEC1B Gene
- GC12M010037
- GC12M010145
- GC12M009888
- GC12M010147
- GC12M010260
- GC12M010502
- GC12M010076
- GC12M010609
- GC12M010768
- GC12M011006
- GC12M011296
- GC12M011530
- GC12M011723
Summaries for CLEC1B Gene
-
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]
GeneCards Summary for CLEC1B Gene
CLEC1B (C-Type Lectin Domain Family 1 Member B) is a Protein Coding gene. Diseases associated with CLEC1B include Human Immunodeficiency Virus Type 1. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and G beta-gamma signalling through PI3Kgamma. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLEC12B.
UniProtKB/Swiss-Prot for CLEC1B Gene
-
C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485).
-
(Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485). Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).
Additional gene information for CLEC1B Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC1B Gene
Genomics for CLEC1B Gene
GeneHancer (GH) Regulatory Elements for CLEC1B Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12I010000 | Promoter | 0.7 | EPDnew | 550.4 | +14.2 | 14183 | 0.1 | MAFG NFE2 | CLEC1B CLEC12A-AS1 CLEC12A CLEC9A LOC102724020 CLEC12B | |
GH12I009999 | Promoter | 0.5 | EPDnew | 550.4 | +14.1 | 14053 | 0.1 | CLEC1B CLEC12A-AS1 CLEC12A CLEC9A LOC102724020 CLEC12B | ||
GH12I009942 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 10.5 | +69.7 | 69725 | 2.2 | MAZ SP2 GABPA ZSCAN21 HIC1 ZNF366 GLIS1 PATZ1 ZNF629 PRDM10 | LINC02470 OLR1 CLEC12A CLEC7A CLEC1B GABARAPL1 CD69 | |
GH12I009948 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 10.8 | +64.5 | 64475 | 1.1 | PKNOX1 BMI1 BATF IRF4 ATF7 ETV6 IKZF2 RUNX3 TRIM22 JUNB | CLEC12A CLEC12B CLEC1B CLEC7A CLEC9A LOC102724020 CLEC12A-AS1 LINC02470 | |
GH12I009947 | Enhancer | 0.8 | ENCODE dbSUPER | 10.8 | +65.6 | 65567 | 0.1 | JUNB DPF2 BATF ATF2 IRF4 IKZF1 RUNX3 IKZF2 SPI1 | CLEC12B CLEC1B CLEC7A CLEC9A LOC102724020 CLEC12A LINC02470 |
- Top Transcription factor binding sites by QIAGEN in the CLEC1B gene promoter:
Regulatory Element Products
Genomic Locations for CLEC1B Gene
- chr12:9,985,642-10,013,424
- (GRCh38/hg38)
- Size:
- 27,783 bases
- Orientation:
- Minus strand
- chr12:10,138,241-10,166,023
- (GRCh37/hg19)
Genomic View for CLEC1B Gene
- Cytogenetic band:
-
- 12p13.2 by Ensembl
- 12p13.31-p13.2 by Entrez Gene
- 12p13.31-p13.2 by HGNC


RefSeq DNA sequence for CLEC1B Gene
Proteins for CLEC1B Gene
-
Protein details for CLEC1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P126-CLC1B_HUMAN
- Recommended name:
- C-type lectin domain family 1 member B
- Protein Accession:
- Q9P126
- Q6UWX7
- Q8NHR6
Protein attributes for CLEC1B Gene
- Size:
- 229 amino acids
- Molecular mass:
- 26596 Da
- Quaternary structure:
-
- Homodimer. Interacts (via cytoplasmic domain) with RACK1; promotes CLEC1B ubiquitination and proteasome-mediated degradation. Interacts (dimer) with SYK (via SH2 domains). Interacts with PDPN; the interaction is independent of CLEC1B glycosylation and activates CLEC1B (PubMed:18215137).
Protein Expression for CLEC1B Gene
Post-translational modifications for CLEC1B Gene
- Glycosylated.
- Phosphorylated on tyrosine residue in response to rhodocytin binding.
- Glycosylation at posLast=6868, posLast=120120, and posLast=134134
Other Protein References for CLEC1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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-
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-
Quality Products:
No data available for DME Specific Peptides for CLEC1B Gene
Domains & Families for CLEC1B Gene
Gene Families for CLEC1B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CLEC1B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CLEC1B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CLEC1B Gene
Function for CLEC1B Gene
Molecular function for CLEC1B Gene
- UniProtKB/Swiss-Prot Function:
- C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485). Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).
Phenotypes From GWAS Catalog for CLEC1B Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IDA | 18955485 |
GO:0005515 | protein binding | IPI | 17616532 |
GO:0030246 | carbohydrate binding | IEA | -- |
Phenotypes for CLEC1B Gene
- MGI mutant phenotypes for CLEC1B:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for CLEC1B:
Animal Models for CLEC1B Gene
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-
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-
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miRNA for CLEC1B Gene
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Clone Products
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-
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CLEC1B
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLEC1B Gene
Localization for CLEC1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLEC1B Gene
- Membrane; Single-pass type II membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS,IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC1B Gene
Pathways & Interactions for CLEC1B Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
2 | G beta-gamma signalling through PI3Kgamma |
Pathways by source for CLEC1B Gene
3 Reactome pathways for CLEC1B Gene
Interacting Proteins for CLEC1B Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006952 | defense response | TAS | 10671229 |
GO:0007166 | cell surface receptor signaling pathway | TAS | 10671229 |
GO:0023014 | signal transduction by protein phosphorylation | IDA | 18955485 |
GO:0030168 | platelet activation | TAS | -- |
GO:0030220 | platelet formation | IEA | -- |
No data available for SIGNOR curated interactions for CLEC1B Gene
Transcripts for CLEC1B Gene
mRNA/cDNA for CLEC1B Gene
- (7) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CLEC1B Gene
CRISPR Products
-
OriGene CRISPR knockouts for CLEC1B
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CLEC1B
- genomics-online: cdna clones - Search results for available CLEC1B gene related products
- orf clones - Search results for available CLEC1B gene related products
- Applied Biological Materials Clones for CLEC1B
-
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Expression for CLEC1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Megakaryocytes Hematopoietic Bone Marrow
- Skeletal Muscle (Muscoskeletal System)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Trophoblast (Extraembryonic Tissues)
-
Lung (Respiratory System)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for CLEC1B Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLEC1B Gene
NURSA nuclear receptor signaling pathways regulating expression of CLEC1B Gene:
CLEC1BSOURCE GeneReport for Unigene cluster for CLEC1B Gene:
Hs.409794mRNA Expression by UniProt/SwissProt for CLEC1B Gene:
Q9P126-CLC1B_HUMANEvidence on tissue expression from TISSUES for CLEC1B Gene
- Liver(4.4)
- Blood(2.4)
Primer Products
-
OriGene qPCR primer pairs for CLEC1B
-
OriGene qPCR primer pairs and template standards for CLEC1B
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No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC1B Gene
Orthologs for CLEC1B Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CLEC1B 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | CLEC1B 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Clec1b 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Clec1b 33 |
|
||
dog (Canis familiaris) |
Mammalia | CLEC1B 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | CLEC1B 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | CLEC1B 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany |
- Species where no ortholog for CLEC1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CLEC1B Gene
(11) SIMAP similar genes for CLEC1B Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for CLEC1B Gene
Variants for CLEC1B Gene
SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000112368 | -- | 9,990,957(-) | C/T | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
rs1000443074 | -- | 9,990,712(-) | A/G | downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant | |
rs1000961036 | -- | 9,995,984(-) | A/G | intron_variant | |
rs1001046687 | -- | 9,988,477(-) | C/A/T | genic_downstream_transcript_variant, intron_variant | |
rs1001144662 | -- | 9,988,334(-) | C/T | genic_downstream_transcript_variant, intron_variant |
Additional Variant Information for CLEC1B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CLEC1B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC1B Gene
Disorders for CLEC1B Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
human immunodeficiency virus type 1 |
|
|
Additional Disease Information for CLEC1B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CLEC1B Gene
Publications for CLEC1B Gene
- Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. (PMID: 10671229) Colonna M … Angman L (European journal of immunology 2000) 2 3 4 22 58
- Renal cells activate the platelet receptor CLEC-2 through podoplanin. (PMID: 18215137) Christou CM … O'Callaghan CA (The Biochemical journal 2008) 3 4 22 58
- G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2. (PMID: 18955485) Mori J … Watson SP (The Journal of biological chemistry 2008) 3 4 22 58
- DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. (PMID: 16940507) Chaipan C … Pöhlmann S (Journal of virology 2006) 3 4 22 58
- A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. (PMID: 11745369) Sobanov Y … Hofer E (European journal of immunology 2001) 2 3 22 58
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CLEC1B
- antibodies-online: Search results for 124 available CLEC1B Antibodies ranked by validation data
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- Search Santa Cruz Biotechnology (SCBT) for CLEC1B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CLEC1B
- Horizon Cell Lines for CLEC1B
- genomics-online: cdna clones - Search results for available CLEC1B gene related products
- orf clones - Search results for available CLEC1B gene related products
- genomics-online: gRNA clones - Search results for available CLEC1B gene related products
- genomics-online: primer clones - Search results for available CLEC1B gene related products
- genomics-online: shRNA clones - Search results for available CLEC1B gene related products
Sources for CLEC1B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew