CLEC1B Gene

Aliases
for CLEC1B gene

Previous GC identifers: GC12M010037 GC12M010145 GC12M009888

Summaries
for CLEC1B gene

Genomic Views
for CLEC1B gene

RefSeq DNA sequence:

NC_000012.11  NC_018923.1  NT_009714.17  

SwitchGear Promoter luciferase reporter plasmid: CLEC1B promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC1B

CLEC1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010147:  view genomic region     (about GC identifiers)

Proteins
for CLEC1B gene

1 PDB 3D structure from and Proteopedia for CLEC1B:

2C6U (3D)    

Explore the universe of human proteins at neXtProt for CLEC1B: NX_Q9P126

Post-translational modifications:

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	R&D Systems Recombinant & Natural Proteins for CLEC1B (CLEC-2)
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	Novus Biologicals CLEC1B Proteins Novus Biologicals CLEC1B Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CLEC1B

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

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	Novus Biologicals CLEC1B Antibodies
	Search for Antibodies for CLEC1B at Abcam
	Uscn Antibodies for CLEC1B
	ThermoFisher Antibodies for CLEC1B

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for CLEC1B (CLEC-2)
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CLEC1B

Protein Domains /
Families
for CLEC1B gene

ProtoNet protein and cluster: Q9P126

Function
for CLEC1B gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC1B
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLEC1B
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC1B (see all 4) OriGene shRNA RFP: CLEC1B OriGene siRNA: CLEC1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC1B

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CLEC1B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC1B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC1B (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CLEC1B (NM_016509)
		Sino Biological Human cDNA Clone for CLEC1B
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC1B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CLEC1B
		Search LifeMap BioReagents cell lines for CLEC1B

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC1B

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 6 alleles) (MGI details for Clec1b)

Pathways & Interactions
for CLEC1B gene

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for CLEC1B gene

Transcripts
for CLEC1B gene

Expression
for CLEC1B gene

CLEC1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCGGAAAT

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Skeletal MuscleHyoid Arch MusclesMyoblasts			Skeletal Muscle
	Skeletal MuscleMandibular Arch MusclesMyoblasts			Skeletal Muscle
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 5 LifeMap Cells
	Name			Category
	Trophoblast-like cells (Generation of tropho...)
	CD31, CD144 positive cells (Two-step protocol fo...)
	Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)
	Mesendoderm (Derivation and sorti...)
	Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC1B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC1B

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC1B

Orthologs
for CLEC1B gene

Paralogs
for CLEC1B gene

Paralogs for CLEC1B gene

CLEC9A²  OLR1²  KLRC2²  ENSG00000255819²  CLEC12A²  CLEC1A²  KLRC3²  KLRD1²  

KLRK1²  KLRC4²  ENSG00000255641²  CLEC7A²  KLRC1²  CLEC12B²  

13 SIMAP similar genes for CLEC1B using alignment to 2 protein entries:     CLC1B_HUMAN (see all proteins):

KLRD1    KLRC1    KLRC2    OLR1    CLEC1A    VCAN

CLEC10A    CLEC2L    CLEC7A    CLEC12B    NCAN    CLEC4C

KLRG1

CLEC1B for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CLEC1B
PGOHUM00000251014

Genomic Variants
for CLEC1B gene

10/200 NCBI SNPs in CLEC1B are shown (see all 200)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1857549541,2		--	10145226(+)	AAATAC/TGAGAA	2	--	ds5001		0	--	--	--	--
rs6138711,2	C,F,O,A,H,	--	10145341(-)	AAGGCA/GGTGTA	2	--	ds5001		29		EA NA NS WA CSA	2540
rs1461985411,2		--	10145389(+)	TATTTC/TGCACA	2	--	ds5001		0	--	--	--	--
rs714500151,2	C,	--	10145587(+)	AAGAAG/AGGACT	2	--	ds5001		1		NA	2
rs1885747131,2	C,F,	--	10145739(+)	TCTTTG/CCATTA	2	--	ut31		1		EU	1323
rs1998593111,2		--	10145761(+)	CCACCC/TTGGTC	4	K R	mis1		0	--	--	--	--
rs2021153201,2		--	10145767(+)	TGGTCA/TTGCCA	4	K M	mis1		0	--	--	--	--
rs1809013801,2		--	10145835(+)	CCATTA/GTGAAA	4	H	syn1		0	--	--	--	--
rs123010361,2	H,	--	10145937(+)	CAATCA/CGTAAT	2	--	int1		4		NS EA	420
rs177343351,2	C,F,	--	10145952(+)	CTCTGC/TGTATA	2	--	int1		4		NA	260

HapMap Linkage Disequilibrium report for CLEC1B (10138241 - 10166023 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CLEC1B
     1 Inversion: 59704

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC1B

DNA2.0 Custom Variant and Variant Library Synthesis for CLEC1B

Disorders / Diseases
for CLEC1B gene

Publications
for CLEC1B gene

PubMed articles for CLEC1B gene, integrated from 9 sources (see all 34): (articles sorted by number of sources associating them with CLEC1B)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. (PubMed id 10671229)^{1, 2, 3, 9} Colonna M.... Angman L. (2000)
2. DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. (PubMed id 16940507)^{1, 2, 9} Chaipan C.... Poehlmann S. (2006)
3. A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. (PubMed id 11745369)^{1, 3, 9} Sobanov Y.... Hofer E. (2001)
4. CLEC-2 activates Syk through dimerization. (PubMed id 20154219)^{1, 2} Hughes C.E....Watson S.P. (2010)
5. The platelet receptor CLEC-2 is active as a dimer. (PubMed id 19824697)^{1, 2} Watson A.A....O'Callaghan C.A. (2009)
6. RACK1 associates with CLEC-2 and promotes its ubiquit in-proteasome degradation. (PubMed id 19785988)^{1, 2} Ruan Y....Gu J. (2009)
7. The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2. (PubMed id 17132623)^{1, 2} Watson A.A....O'Callaghan C.A. (2007)
8. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. (PubMed id 16174766)^{1, 2} Suzuki-Inoue K.... Watson S.P. (2006)
9. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)^{1, 2} Scherer S.E.... Gibbs R.A. (2006)
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

External Searches for CLEC1B gene

Genome Databases showing CLEC1B gene

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Specialized Databases showing CLEC1B gene

Products
for CLEC1B gene