Aliases for CLEC1B Gene
Aliases for CLEC1B Gene
External Ids for CLEC1B Gene
- HGNC: 24356
- Entrez Gene: 51266
- Ensembl: ENSG00000165682
- OMIM: 606783
- UniProtKB: Q9P126
Previous GeneCards Identifiers for CLEC1B Gene
- GC12M010037
- GC12M010145
- GC12M009888
- GC12M010147
- GC12M010260
- GC12M010502
- GC12M010076
- GC12M010609
Summaries for CLEC1B Gene
-
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]
GeneCards Summary for CLEC1B Gene
CLEC1B (C-Type Lectin Domain Family 1 Member B) is a Protein Coding gene. Among its related pathways are G beta-gamma signalling through PI3Kgamma and Platelet activation, signaling and aggregation. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLEC7A.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC1B Gene
Genomics for CLEC1B Gene
Regulatory Elements for CLEC1B Gene
Enhancers for CLEC1B Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around CLEC1B on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CLEC1B gene promoter:
Regulatory Element Products
Genomic Location for CLEC1B Gene
- Chromosome:
- 12
- Start:
- 9,985,642 bp from pter
- End:
- 10,013,424 bp from pter
- Size:
- 27,783 bases
- Orientation:
- Minus strand
Genomic View for CLEC1B Gene
Genes around CLEC1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.2 by Ensembl
- 12p13.2 by Entrez Gene
- 12p13.31 by HGNC
CLEC1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CLEC1B Gene
Proteins for CLEC1B Gene
-
Protein details for CLEC1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P126-CLC1B_HUMAN
- Recommended name:
- C-type lectin domain family 1 member B
- Protein Accession:
- Q9P126
- Q6UWX7
- Q8NHR6
Protein attributes for CLEC1B Gene
- Size:
- 229 amino acids
- Molecular mass:
- 26596 Da
- Quaternary structure:
-
- Homodimer. Interacts (via cytoplasmic domain) with RACK1; promotes CLEC1B ubiquitination and proteasome-mediated degradation. Interacts (dimer) with SYK (via SH2 domains).
- Miscellaneous:
-
- Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2 (PubMed:16174766). Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).
Protein Expression for CLEC1B Gene
Post-translational modifications for CLEC1B Gene
- Glycosylated.
- Phosphorylated on tyrosine residue in response to rhodocytin binding.
- Glycosylation at Asn 68, Asn 120, and Asn 134
- Modification sites at PhosphoSitePlus
Other Protein References for CLEC1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CLEC1B (CLEC-2/CLEC1B)
- Novus Biologicals Antibodies for CLEC1B
- Abcam antibodies for CLEC1B
- Invitrogen Antibodies for CLEC1B
- antibodies-online Antibodies for CLEC1B: See all 64
- GeneTex CLEC1B antibody for CLEC1B
-
Santa Cruz Biotechnology (SCBT) Antibodies for CLEC1B
Protein Products
- R&D Systems Proteins and Enzymes for CLEC1B (CLEC-2/CLEC1B)
-
OriGene Purified Proteins for CLEC1B
- Search Origene for MassSpec and Protein Over-expression Lysates for CLEC1B
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- Sino Biological Recombinant Proteins for CLEC1B
- antibodies-online Proteins for CLEC1B: See all 9
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- Abcam proteins for CLEC1B
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for CLEC1B (CLEC-2/CLEC1B)
- antibodies-online Kits for CLEC1B: See all 9
No data available for DME Specific Peptides for CLEC1B Gene
Domains & Families for CLEC1B Gene
Gene Families for CLEC1B Gene
Protein Domains for CLEC1B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CLEC1B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9P126- Domain:
-
- Contains 1 C-type lectin domain.
Function for CLEC1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | TAS | 10671229 |
Phenotypes for CLEC1B Gene
- MGI mutant phenotypes for CLEC1B:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for CLEC1B:
Animal Models for CLEC1B Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CLEC1B
-
ViGene Biosciences lentiviral particle packaged cDNA for CLEC1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CLEC1B gene
- Search ViGene Biosciences for CLEC1B
CRISPR Products
-
OriGene CRISPR knockouts for CLEC1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLEC1B
- GenScript: Design CRISPR guide RNA sequences for CLEC1B
miRNA for CLEC1B Gene
- miRTarBase miRNAs that target CLEC1B
miRNA Products
- Search ViGene Biosciences for CLEC1B
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for CLEC1B
- Browse OriGene Inhibitory RNA Products For CLEC1B
-
ViGene Biosciences ready-to-package AAV shRNAs for CLEC1B gene
Clone Products
- OriGene clones in human for CLEC1B
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CLEC1B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CLEC1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CLEC1B gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLEC1B Gene
Localization for CLEC1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLEC1B Gene
- Membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 1 |
| extracellular | 1 |
| golgi apparatus | 1 |
| mitochondrion | 1 |
No data available for Gene Ontology (GO) - Cellular Components for CLEC1B Gene
Pathways & Interactions for CLEC1B Gene
More details on SuperPathways for CLEC1B| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Platelet activation, signaling and aggregation |
.45
|
|
| 2 | G beta-gamma signalling through PI3Kgamma |
Pathways by source for CLEC1B Gene
3 Reactome pathways for CLEC1B Gene
Interacting Proteins for CLEC1B Gene
Selected Interacting proteins:
Q9P126-CLC1B_HUMAN
ENSP00000298527
for CLEC1B Gene via
MINT
STRING
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007166 | cell surface receptor signaling pathway | TAS | 10671229 |
| GO:0030220 | platelet formation | IEA | -- |
No data available for SIGNOR curated interactions for CLEC1B Gene
Transcripts for CLEC1B Gene
mRNA/cDNA for CLEC1B Gene
- (5) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CLEC1B Gene
CRISPR Products
-
OriGene CRISPR knockouts for CLEC1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLEC1B
- GenScript: Design CRISPR guide RNA sequences for CLEC1B
miRNA Products
- Search ViGene Biosciences for CLEC1B
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for CLEC1B
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-
ViGene Biosciences ready-to-package AAV shRNAs for CLEC1B gene
Clone Products
- OriGene clones in human for CLEC1B
- OriGene ORF clones in human,mouse,rat for CLEC1B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CLEC1B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for CLEC1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Megakaryocytes Hematopoietic Bone Marrow
- Skeletal Muscle (Muscoskeletal System)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Trophoblast (Extraembryonic Tissues)
-
Lung (Respiratory System)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for CLEC1B Gene
This gene is overexpressed in Liver (x22.4) and Whole Blood (x17.8).
This gene is overexpressed in Peripheral blood mononuclear cells (37.9) and Platelet (30.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC1B Gene
SOURCE GeneReport for Unigene cluster for CLEC1B Gene Hs.409794
mRNA Expression by UniProt/SwissProt for CLEC1B Gene
Q9P126-CLC1B_HUMAN
Tissue specificity:
Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.
Primer Products
-
OriGene qPCR primer pairs for CLEC1B
-
OriGene qPCR primer pairs and template standards for CLEC1B
Orthologs for CLEC1B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | CLEC1B 35 |
|
||
| CLEC1B 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Clec1b 35 |
|
||
| Clec1b 16 |
|
||||
| Clec1b 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | CLEC1B 35 |
|
||
| CLEC1B 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Clec1b 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CLEC1B 36 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CLEC1B 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CLEC1B 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
OneToMany |
- Species with no ortholog for CLEC1B:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CLEC1B Gene
(11) SIMAP similar genes for CLEC1B Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for CLEC1B Gene
Variants for CLEC1B Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_031047 | - | ||||
| VAR_031048 | - | ||||
| VAR_031049 | - | ||||
| VAR_031050 | - | ||||
| rs10845017 | -- | 10,002,558(+) | CTGCC(A/T)CAGCC | upstream-variant-2KB |
Residual Variation Intolerance Score:
73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.63;
72.63% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CLEC1B Gene
Disorders for CLEC1B Gene
Relevant External Links for CLEC1B
No disorders were found for CLEC1B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC1B Gene
Publications for CLEC1B Gene
- Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. (PMID: 10671229) Colonna M. … Angman L. (Eur. J. Immunol. 2000) 2 3 4 23 67
- A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. (PMID: 11745369) Sobanov Y. … Hofer E. (Eur. J. Immunol. 2001) 2 3 23
- Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac. (PMID: 20154214) Pollitt A.Y. … Watson S.P. (Blood 2010) 3 23
- Renal cells activate the platelet receptor CLEC-2 through podoplanin. (PMID: 18215137) Christou C.M. … O'Callaghan C.A. (Biochem. J. 2008) 3 23
- Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2. (PMID: 18583525) Watson A.A. … O'Callaghan C.A. (Protein Sci. 2008) 3 23
Products for CLEC1B Gene
- R&D Systems Antibodies for CLEC1B (CLEC-2/CLEC1B)
- R&D Systems Proteins and Enzymes for CLEC1B (CLEC-2/CLEC1B)
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for CLEC1B (CLEC-2/CLEC1B)
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- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for CLEC1B
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- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for CLEC1B
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- OriGene qPCR primer pairs for CLEC1B
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Novus Biologicals Antibodies for CLEC1B
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- Taconic Biosciences Mouse Models for CLEC1B
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for CLEC1B: See all 64
- antibodies-online Kits for CLEC1B: See all 9
- antibodies-online Proteins for CLEC1B: See all 9
- Search antibodies-online for peptides
- GeneTex CLEC1B antibody for CLEC1B
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- ViGene Biosciences adenoviral particle packaged cDNA for CLEC1B gene
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- ViGene Biosciences ready-to-package AAV shRNAs for CLEC1B gene
- ViGene Biosciences ready-to-package AAV shRNAs for CLEC1B gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for CLEC1B
- Search Santa Cruz Biotechnology (SCBT) for CLEC1B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CLEC1B
Sources for CLEC1B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
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- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
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- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
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- (149) ENCODE
- (150) ProSci
- (151) Horizon