Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLEC1B Gene

Aliases for CLEC1B Gene

  • C-Type Lectin Domain Family 1 Member B 2 3 5
  • C-Type Lectin-Like Receptor 2 3 4
  • CLEC-2 3 4
  • CLEC2 3 4
  • C-Type Lectin Domain Family 1, Member B 2
  • 1810061I13Rik 3
  • PRO1384 3
  • QDED721 3
  • CLEC2B 3

External Ids for CLEC1B Gene

Previous GeneCards Identifiers for CLEC1B Gene

  • GC12M010037
  • GC12M010145
  • GC12M009888
  • GC12M010147
  • GC12M010260
  • GC12M010502
  • GC12M010076
  • GC12M010609
  • GC12M010768
  • GC12M011006

Summaries for CLEC1B Gene

Entrez Gene Summary for CLEC1B Gene

  • Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]

GeneCards Summary for CLEC1B Gene

CLEC1B (C-Type Lectin Domain Family 1 Member B) is a Protein Coding gene. Among its related pathways are G beta-gamma signalling through PI3Kgamma and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLEC12B.

Gene Wiki entry for CLEC1B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC1B Gene

Genomics for CLEC1B Gene

Regulatory Elements for CLEC1B Gene

Enhancers for CLEC1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F009947 1 Ensembl ENCODE 10.8 +64.8 64824 2.0 PKNOX1 FEZF1 BMI1 ZFHX2 CBX5 ETV6 RFX1 JUNB TBX21 RAD51 CLEC12A CLEC12B CLEC1B CLEC7A CLEC9A LOC102724020 LOC100506159
GH12F009943 0.7 ENCODE 10.5 +70.1 70071 1.1 MAZ RNF2 SP2 REST HIC1 ZNF366 PATZ1 GLIS1 ZNF600 PRDM10 LOC100506159 CLEC12A CLEC7A CLEC1B CLEC2A
GH12F009857 0.4 Ensembl 10.6 +156.3 156324 0.2 IKZF1 KLRF1 CLEC1B CLEC9A LOC102724020 ENSG00000255882
GH12F010119 1 FANTOM5 Ensembl 1.3 -107.2 -107177 3.2 RNF2 MAX CEBPB CEBPG KDM1A NFE2 MYC NFE2L2 CLEC7A CLEC12A CLEC2B CLEC9A OLR1 GABARAPL1 KLRD1 CLEC1B LOC105369655
GH12F010016 0.9 Ensembl ENCODE 0.8 -4.3 -4308 2.5 JUN MAFG RFX5 JUND ZNF316 PBX2 NFE2L1 NFE2 MAFK NFE2L2 CLEC12A LOC400002 CLEC7A KLRF1 LOC100506159 CLEC1B GC12P010023
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLEC1B on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC1B Gene

Chromosome:
12
Start:
9,985,642 bp from pter
End:
10,013,424 bp from pter
Size:
27,783 bases
Orientation:
Minus strand

Genomic View for CLEC1B Gene

Genes around CLEC1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC1B Gene

Proteins for CLEC1B Gene

  • Protein details for CLEC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P126-CLC1B_HUMAN
    Recommended name:
    C-type lectin domain family 1 member B
    Protein Accession:
    Q9P126
    Secondary Accessions:
    • Q6UWX7
    • Q8NHR6

    Protein attributes for CLEC1B Gene

    Size:
    229 amino acids
    Molecular mass:
    26596 Da
    Quaternary structure:
    • Homodimer. Interacts (via cytoplasmic domain) with RACK1; promotes CLEC1B ubiquitination and proteasome-mediated degradation. Interacts (dimer) with SYK (via SH2 domains).
    Miscellaneous:
    • Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2 (PubMed:16174766). Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).

    Three dimensional structures from OCA and Proteopedia for CLEC1B Gene

    Alternative splice isoforms for CLEC1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC1B Gene

Post-translational modifications for CLEC1B Gene

Antibody Products

  • R&D Systems Antibodies for CLEC1B (CLEC-2/CLEC1B)
  • Abcam antibodies for CLEC1B

No data available for DME Specific Peptides for CLEC1B Gene

Domains & Families for CLEC1B Gene

Gene Families for CLEC1B Gene

Protein Domains for CLEC1B Gene

Suggested Antigen Peptide Sequences for CLEC1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P126

UniProtKB/Swiss-Prot:

CLC1B_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC1B: view

Function for CLEC1B Gene

Gene Ontology (GO) - Molecular Function for CLEC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10671229
GO:0005515 protein binding IPI 19785988
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC1B: view
genes like me logo Genes that share phenotypes with CLEC1B: view

Animal Models for CLEC1B Gene

MGI Knock Outs for CLEC1B:

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC1B

miRNA for CLEC1B Gene

miRTarBase miRNAs that target CLEC1B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLEC1B Gene

Localization for CLEC1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC1B Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC1B gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CLEC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC1B: view

Pathways & Interactions for CLEC1B Gene

genes like me logo Genes that share pathways with CLEC1B: view

Pathways by source for CLEC1B Gene

Interacting Proteins for CLEC1B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000298527%0d%0a9606.ENSP00000278886%0d%0a
Selected Interacting proteins: ENSP00000298527 Q9P126-CLC1B_HUMAN for CLEC1B Gene via STRING IID

Gene Ontology (GO) - Biological Process for CLEC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 10671229
GO:0007166 cell surface receptor signaling pathway TAS 10671229
GO:0030168 platelet activation TAS --
GO:0030220 platelet formation IEA --
genes like me logo Genes that share ontologies with CLEC1B: view

No data available for SIGNOR curated interactions for CLEC1B Gene

Transcripts for CLEC1B Gene

mRNA/cDNA for CLEC1B Gene

Unigene Clusters for CLEC1B Gene

C-type lectin domain family 1, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC1B Gene

No ASD Table

Relevant External Links for CLEC1B Gene

GeneLoc Exon Structure for
CLEC1B
ECgene alternative splicing isoforms for
CLEC1B

Expression for CLEC1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLEC1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC1B Gene

This gene is overexpressed in Liver (x22.4) and Whole Blood (x17.8).

Protein differential expression in normal tissues from HIPED for CLEC1B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (37.9) and Platelet (30.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC1B Gene



Protein tissue co-expression partners for CLEC1B Gene

NURSA nuclear receptor signaling pathways regulating expression of CLEC1B Gene:

CLEC1B

SOURCE GeneReport for Unigene cluster for CLEC1B Gene:

Hs.409794

mRNA Expression by UniProt/SwissProt for CLEC1B Gene:

Q9P126-CLC1B_HUMAN
Tissue specificity: Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.
genes like me logo Genes that share expression patterns with CLEC1B: view

Primer Products

Orthologs for CLEC1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC1B 34 35
  • 98.25 (n)
cow
(Bos Taurus)
Mammalia CLEC1B 34 35
  • 78.81 (n)
mouse
(Mus musculus)
Mammalia Clec1b 34 16 35
  • 75.52 (n)
rat
(Rattus norvegicus)
Mammalia Clec1b 34
  • 74.19 (n)
dog
(Canis familiaris)
Mammalia CLEC1B 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLEC1B 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLEC1B 35
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
OneToMany
Species where no ortholog for CLEC1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC1B Gene

ENSEMBL:
Gene Tree for CLEC1B (if available)
TreeFam:
Gene Tree for CLEC1B (if available)

Paralogs for CLEC1B Gene

Paralogs for CLEC1B Gene

(11) SIMAP similar genes for CLEC1B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CLEC1B Gene

genes like me logo Genes that share paralogs with CLEC1B: view

Variants for CLEC1B Gene

Sequence variations from dbSNP and Humsavar for CLEC1B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10431294 -- 9,998,629(+) AAGGC(C/T)TGATG intron-variant, upstream-variant-2KB
rs10505742 -- 9,999,979(+) CATTA(A/T)TTTAG intron-variant, upstream-variant-2KB
rs10505743 -- 10,000,427(+) GTATA(A/C)AAGAC intron-variant, upstream-variant-2KB
rs10772223 -- 10,001,650(+) GTAAG(C/T)TGAGT intron-variant, upstream-variant-2KB
rs10772224 -- 10,003,440(+) ATACA(A/G)AACAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLEC1B Gene

Variant ID Type Subtype PubMed ID
nsv604 CNV deletion 18451855
nsv525593 CNV loss 19592680
esv9698 OTHER inversion 19470904
dgv1374n100 CNV gain 25217958

Variation tolerance for CLEC1B Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.63; 72.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC1B Gene

Disorders for CLEC1B Gene

Relevant External Links for CLEC1B

Genetic Association Database (GAD)
CLEC1B
Human Genome Epidemiology (HuGE) Navigator
CLEC1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC1B

No disorders were found for CLEC1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC1B Gene

Publications for CLEC1B Gene

  1. Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. (PMID: 10671229) Colonna M. … Angman L. (Eur. J. Immunol. 2000) 2 3 4 22 64
  2. DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. (PMID: 16940507) Chaipan C. … Poehlmann S. (J. Virol. 2006) 3 4 22 64
  3. A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. (PMID: 11745369) Sobanov Y. … Hofer E. (Eur. J. Immunol. 2001) 2 3 22 64
  4. Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac. (PMID: 20154214) Pollitt A.Y. … Watson S.P. (Blood 2010) 3 22 64
  5. CLEC-2 activates Syk through dimerization. (PMID: 20154219) Hughes C.E. … Watson S.P. (Blood 2010) 3 4 64

Products for CLEC1B Gene

Sources for CLEC1B Gene

Content
Loading form....