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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC1B Gene

protein-coding   GIFtS: 54
GCID: GC12M010260

C-Type Lectin Domain Family 1, Member B
  3 related diseases
at
MalaCards
 

Aliases
for CLEC1B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
C-Type Lectin Domain Family 1, Member B1 2     1810061I13Rik2
CLEC22 3 5     PRO13842
CLEC-22 3     QDED7212
C-Type Lectin-Like Receptor 22 3     C-Type Lectin Domain Family 1 Member B2
CLEC2B2 5     C-Type Lectin-Like Receptor-22

External Ids:    HGNC: 243561   Entrez Gene: 512662   Ensembl: ENSG000001656827   OMIM: 6067835   UniProtKB: Q9P1263   

Export aliases for CLEC1B gene to outside databases

Previous GC identifers: GC12M010037 GC12M010145 GC12M009888 GC12M010147


Summaries
for CLEC1B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLEC1B Gene:
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1;
MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules
and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor
expressed in myeloid cells and NK cells (Colonna et al., 2000 (PubMed 10671229)).(supplied by OMIM, Jan 2011)

GeneCards Summary for CLEC1B Gene: 
CLEC1B (C-type lectin domain family 1, member B) is a protein-coding gene. Diseases associated with CLEC1B include hepatitis b, and endotheliitis. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is OLR1.

UniProtKB/Swiss-Prot: CLC1B_HUMAN, Q9P126
Function: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads
to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of
downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human
immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets

Gene Wiki entry for CLEC1B Gene


Genomic Views
for CLEC1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC1B gene promoter:
         TBP   AML1a   NRSF form 1   FOXD3   MyoD   Pax-2   Pax-2a   NRSF form 2   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLEC1B promoter sequence
   Search SABiosciences Chromatin IP Primers for CLEC1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.31

CLEC1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC1B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010260:  view genomic region     (about GC identifiers)

Start:
 10,138,241 bp from pter      End:
 10,166,023 bp from pter
Size:
 27,783 bases      Orientation:
 minus strand

Proteins
for CLEC1B gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: CLC1B_HUMAN, Q9P126 (See protein sequence)
Recommended Name: C-type lectin domain family 1 member B  
Size: 229 amino acids; 26596 Da
Subunit: Homodimer. Interacts (via cytoplasmic domain) with GNB2L1/RACK1; promotes CLEC1B ubiquitination and
proteasome-mediated degradation. Interacts (dimer) with SYK (via SH2 domains)
Subcellular location: Membrane; Single-pass type II membrane protein (Probable)
1 PDB 3D structure from and Proteopedia for CLEC1B:
2C6U (3D)    
Secondary accessions: Q6UWX7 Q8NHR6
Alternative splicing: 2 isoforms:  Q9P126-1   Q9P126-2   

Explore the universe of human proteins at neXtProt for CLEC1B: NX_Q9P126

Explore proteomics data for CLEC1B at MOPED 

Post-translational modifications:

  • UniProtKB: Glycosylated
  • UniProtKB: Phosphorylated on tyrosine residue in response to rhodocytin binding
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P126

    • CLEC1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLEC1B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001092901.1  NP_057593.3  

    ENSEMBL proteins: 
     ENSP00000381910   ENSP00000406338   ENSP00000298527   ENSP00000327169  

    Human Recombinant Protein Products for CLEC1B: 
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    Sino Biological Recombinant Protein for CLEC1B
    Sino Biological Cell Lysate for CLEC1B 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLEC1B 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IEA--

    CLEC1B for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for CLEC1B 
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    Protein Domains /
    Families
    for CLEC1B gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q9P126

    ProtoNet protein and cluster: Q9P126

    UniProtKB/Swiss-Prot: CLC1B_HUMAN, Q9P126
    Similarity: Contains 1 C-type lectin domain


    CLEC1B for domains           About GeneDecksing


    Function
    for CLEC1B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLC1B_HUMAN, Q9P126
    Function: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads
    to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of
    downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human
    immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS10671229
    GO:0005515protein binding IPI19785988
    GO:0030246carbohydrate binding IEA--
         
    CLEC1B for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Clec1b):
     cardiovascular system  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  nervous system  respiratory system 

    CLEC1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CLEC1B: Clec1btm1.1Ksi Clec1btm1Lex Clec1btm1.2Arte Clec1btm1Mlkn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLEC1B 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC1B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLEC1B 

    miRNA
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    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CLEC1B

    Clone
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    Sino Biological Human cDNA Clone for CLEC1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC1B
    Sirion Biotech Customized lentivirus for stable overexpression of CLEC1B 
                         Customized lentivirus expression plasmids for stable overexpression of CLEC1B 

    Cell Line
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    Search LifeMap BioReagents cell lines for CLEC1B
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC1B


    Pathways & Interactions
    for CLEC1B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLEC1B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for CLEC1B (Q9P1262, 3 ENSP000002985274) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NINLQ9Y2I62, 3, ENSP000002788864MINT-67394 I2D: score=5 STRING: ENSP00000278886
    SYKP434053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS10671229
    GO:0007166cell surface receptor signaling pathway TAS10671229

    CLEC1B for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLEC1B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLEC1B (CLC1B)

    Search CenterWatch for drugs/clinical trials and news about CLEC1B / CLC1B

    Transcripts
    for CLEC1B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLEC1B gene (2 alternative transcripts): 
    NM_001099431.1  NM_016509.3  

    Unigene Cluster for CLEC1B:

    C-type lectin domain family 1, member B
    Hs.409794  [show with all ESTs]
    Unigene Representative Sequence: BX647321
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398937 ENST00000428126(uc009zhd.3) ENST00000298527(uc001qwu.3)
    ENST00000348658
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CLEC1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC1B
    Clone
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    OriGene ORF clones in mouse, rat for CLEC1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CLEC1B (NM_016509)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC1B
    Sirion Biotech Customized lentivirus for stable overexpression of CLEC1B 
                         Customized lentivirus expression plasmids for stable overexpression of CLEC1B 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC1B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC1B

    Additional mRNA sequence: 

    AF124841.1 AY358599.1 BC029554.1 BX647321.1 

    2 DOTS entries:

    DT.100744741  DT.441659 

    17 AceView cDNA sequences:

    BX102592 AI242915 NM_016509 AI056227 AY358599 AF124841 BI463516 BM971560 
    BC029554 BX647321 AV655580 H70491 AI241548 H69644 R11441 H73462 
    H74038 

    GeneLoc Exon Structure


    Expression
    for CLEC1B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLEC1B expression in normal human tissues (normalized intensities)      CLEC1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCGGAAAT
    CLEC1B Expression
    About this image


    CLEC1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
             Fetal Liver CD34+ Cells   
             cord blood   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Liver (Hepatobiliary System)
             Fetal Liver CD34+ Cells   
     
     Blood Brain Barrier (Nervous System)
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac

    See CLEC1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLEC1B

    SOURCE GeneReport for Unigene cluster: Hs.409794

    UniProtKB/Swiss-Prot: CLC1B_HUMAN, Q9P126
    Tissue specificity: Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on
    the surface of platelets

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    In Situ
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    Orthologs
    for CLEC1B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for CLEC1B gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Clec1b1 , 5 C-type lectin domain family 1, member b1, 5 75.52(n)1
    64.6(a)1    		   6 (63.30 cM)5
    567601  NM_019985.31  NP_064369.11 
     1293972975 


    ENSEMBL Gene Tree for CLEC1B (if available)
    TreeFam Gene Tree for CLEC1B (if available)

    Paralogs
    for CLEC1B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLEC1B gene
    OLR12  CLEC9A2  CLEC7A2  CLEC12B2  CLEC12A2  CLEC1A2  
    11 SIMAP similar genes for CLEC1B using alignment to 2 protein entries:     CLC1B_HUMAN (see all proteins):
    KLRD1    KLRC1    KLRC2    OLR1    CLEC1A    VCAN
    CLEC10A    CLEC2L    CLEC7A    CLEC12B    NCAN

    CLEC1B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLEC1B
    PGOHUM00000251014


    Genomic Variants
    for CLEC1B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/247 SNPs in CLEC1B are shown (see all 247)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1857549541,2
    		--10145226(+) AAATAC/TGAGAA 2 -- ds50010--------
    rs6138711,2
    		C,F,O,A,H--10145341(-) AAGGCA/GGTGTA 2 -- ds500129Minor allele frequency- G:0.47EA NA NS WA CSA 2540
    rs1461985411,2
    		C--10145389(+) TATTTC/TGCACA 2 -- ds50010--------
    rs714500151,2
    		C--10145587(+) AAGAAG/AGGACT 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1885747131,2
    		C,F--10145739(+) TCTTTG/CCATTA 2 -- ut311Minor allele frequency- C:0.00EU 1323
    rs1998593111,2
    		--10145761(+) CCACCC/TTGGTC 4 K R mis10--------
    rs2021153201,2
    		--10145767(+) TGGTCA/TTGCCA 4 K M mis10--------
    rs1809013801,2
    		C--10145835(+) CCATTA/GTGAAA 4 H syn10--------
    rs123010361,2
    		C,F,H--10145937(+) CAATCA/CGTAAT 2 -- int14Minor allele frequency- C:0.00NS EA 420
    rs177343351,2
    		C,F--10145952(+) CTCTGC/TGTATA 2 -- int14Minor allele frequency- T:0.03NA 260

    HapMap Linkage Disequilibrium report for CLEC1B (10138241 - 10166023 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CLEC1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898755CNV Loss21882294
    nsv604CNV Loss18451855
    nsv898756CNV Loss21882294
    nsv525593CNV Loss19592680
    esv9698OTHER Inversion19470904

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC1B
    DNA2.0 Custom Variant and Variant Library Synthesis for CLEC1B

    Disorders / Diseases
    for CLEC1B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 606783    OMIM disorders: --

    3 diseases for CLEC1B:    About MalaCards
    hepatitis b    endotheliitis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for CLEC1B:
    Thrombocytopenia due to platelet alloimmunization

    CLEC1B for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLEC1B
    Human Genome Epidemiology (HuGE) Navigator: CLEC1B (2 documents)

    Export disorders for CLEC1B gene to outside databases

    Publications
    for CLEC1B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLEC1B gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with CLEC1B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. (PubMed id 10671229)1, 2, 3, 9 Colonna M.... Angman L. (2000)
    2. DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. (PubMed id 16940507)1, 2, 9 Chaipan C.... Poehlmann S. (2006)
    3. A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. (PubMed id 11745369)1, 3, 9 Sobanov Y.... Hofer E. (2001)
    4. CLEC-2 activates Syk through dimerization. (PubMed id 20154219)1, 2 Hughes C.E....Watson S.P. (2010)
    5. Genome-wide searching of rare genetic variants in WTC CC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (2010)
    6. The platelet receptor CLEC-2 is active as a dimer. (PubMed id 19824697)1, 2 Watson A.A....O'Callaghan C.A. (2009)
    7. RACK1 associates with CLEC-2 and promotes its ubiquit in-proteasome degradation. (PubMed id 19785988)1, 2 Ruan Y....Gu J. (2009)
    8. The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2. (PubMed id 17132623)1, 2 Watson A.A....O'Callaghan C.A. (2007)
    9. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. (PubMed id 16174766)1, 2 Suzuki-Inoue K.... Watson S.P. (2006)
    10. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)

    External Searches for CLEC1B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CLEC1B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51266 HGNC: 24356 AceView: CLEC2 Ensembl:ENSG00000165682 euGenes: HUgn51266
    ECgene: CLEC1B H-InvDB: CLEC1B

    Other Databases showing CLEC1B gene

    (According to HUGE)
    About This Section
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    Specialized Databases showing CLEC1B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLEC1B Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_240

    Intellectual Property
    for CLEC1B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLEC1B gene:
    Search GeneIP for patents involving CLEC1B

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