CLEC1B Gene

Aliases
for CLEC1B gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC12M010037 GC12M010145 GC12M009888 GC12M010147 GC12M010260

Summaries
for CLEC1B gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CLEC1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000012.11  NT_009714.18  NC_018923.2  

SwitchGear Promoter luciferase reporter plasmid: CLEC1B promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC1B

CLEC1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010502:  view genomic region     (about GC identifiers)

Proteins
for CLEC1B gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for CLEC1B:

2C6U (3D)    

Explore the universe of human proteins at neXtProt for CLEC1B: NX_Q9P126

Explore proteomics data for CLEC1B at MOPED

Post-translational modifications: 

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Domains /
Families
for CLEC1B gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9P126

Find genes that share domains with CLEC1B           About GenesLikeMe

Function
for CLEC1B gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

(inferred from 7 alleles) (MGI details for Clec1b)

genOway: Develop your customized and physiologically relevant rodent model for CLEC1B

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC1B

Localization
for CLEC1B gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	4
extracellular	2
cytosol	1
golgi apparatus	1
mitochondrion	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for CLEC1B gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for CLEC1B gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CLEC1B gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CLEC1B gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CLEC1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCTCGGAAAT

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Blood (Cardiovascular System)    fully expand to see all 2 entries
Megakaryocytes Hematopoietic Bone Marrow
Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
Myoblasts Mandibular Arch Muscles
Endothelium (Cardiovascular System)
Mature Endothelial Cells Blood Brain Barrier
Brain (Nervous System)
Mature Endothelial Cells Blood Brain Barrier
Yolk Sac (Extraembryonic Tissues)
Definitive Hematopoietic Stem Cells Definitive Yolk Sac

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC1B

Orthologs
for CLEC1B gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CLEC1B gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CLEC1B gene

OLR1²  CLEC9A²  CLEC7A²  CLEC12B²  CLEC12A²  CLEC1A²  

11 SIMAP similar genes for CLEC1B using alignment to 2 protein entries:     CLC1B_HUMAN (see all proteins):

KLRD1    KLRC1    KLRC2    OLR1    CLEC1A    VCAN

CLEC10A    CLEC2L    CLEC7A    CLEC12B    NCAN

Find genes that share paralogs with CLEC1B           About GenesLikeMe


1 Pseudogenes.org Pseudogene for CLEC1B
PGOHUM00000251014

Genomic Variants
for CLEC1B gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CLEC1B (see all 247)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1857549541,2		--	10145226(+)	AAATAC/TGAGAA	2	--	ds5001		0	--	--	--	--
rs6138711,2	C,F,O,A,H	--	10145341(-)	AAGGCA/GGTGTA	2	--	ds5001		29		EA NA NS WA CSA	2540
rs1461985411,2	C	--	10145389(+)	TATTTC/TGCACA	2	--	ds5001		0	--	--	--	--
rs714500151,2	C	--	10145587(+)	AAGAAG/AGGACT	2	--	ds5001		1		NA	2
rs1885747131,2	C,F	--	10145739(+)	TCTTTG/CCATTA	2	--	ut31		1		EU	1323
rs1998593111,2		--	10145761(+)	CCACCC/TTGGTC	4	K R	mis1		0	--	--	--	--
rs2021153201,2		--	10145767(+)	TGGTCA/TTGCCA	4	K M	mis1		0	--	--	--	--
rs1809013801,2	C	--	10145835(+)	CCATTA/GTGAAA	4	H	syn1		0	--	--	--	--
rs123010361,2	C,F,H	--	10145937(+)	CAATCA/CGTAAT	2	--	int1		4		NS EA	420
rs177343351,2	C,F	--	10145952(+)	CTCTGC/TGTATA	2	--	int1		4		NA	260

HapMap Linkage Disequilibrium report for CLEC1B (10138241 - 10166023 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for CLEC1B:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv898755	CNV	Loss	21882294
nsv604	CNV	Loss	18451855
nsv898756	CNV	Loss	21882294
nsv525593	CNV	Loss	19592680
esv9698	OTHER	Inversion	19470904

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CLEC1B

DNA2.0 Custom Variant and Variant Library Synthesis for CLEC1B

Disorders / Diseases
for CLEC1B gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for CLEC1B gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CLEC1B gene, integrated from 10 sources (see all 38): (articles sorted by number of sources associating them with CLEC1B)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. (PubMed id 10671229)^{1, 2, 3, 9} Colonna M.... Angman L. (Eur. J. Immunol. 2000)
2. DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. (PubMed id 16940507)^{1, 2, 9} Chaipan C.... Poehlmann S. (J. Virol. 2006)
3. A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. (PubMed id 11745369)^{1, 3, 9} Sobanov Y.... Hofer E. (Eur. J. Immunol. 2001)
4. CLEC-2 activates Syk through dimerization. (PubMed id 20154219)^{1, 2} Hughes C.E.... Watson S.P. (Blood 2010)
5. Genome-wide searching of rare genetic variants in WTCCC data. (PubMed id 20549515)^{1, 4} Feng T. and Zhu X. (Hum. Genet. 2010)
6. The platelet receptor CLEC-2 is active as a dimer. (PubMed id 19824697)^{1, 2} Watson A.A.... O'Callaghan C.A. (Biochemistry 2009)
7. RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation. (PubMed id 19785988)^{1, 2} Ruan Y.... Gu J. (Biochem. Biophys. Res. Commun. 2009)
8. The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2. (PubMed id 17132623)^{1, 2} Watson A.A....O'Callaghan C.A. (J. Biol. Chem. 2007)
9. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. (PubMed id 16174766)^{1, 2} Suzuki-Inoue K.... Watson S.P. (Blood 2006)
10. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)^{1, 2} Scherer S.E.... Gibbs R.A. (Nature 2006)

External Searches for CLEC1B gene

Genome Databases showing CLEC1B gene

Other Databases showing CLEC1B gene

Specialized Databases showing CLEC1B gene

Products
for CLEC1B gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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