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Aliases for CLEC1A Gene

Aliases for CLEC1A Gene

  • C-Type Lectin Domain Family 1 Member A 2 3 5
  • CLEC-1 3 4
  • CLEC1 3 4
  • C-Type Lectin Domain Family 1, Member A 2
  • C-Type Lectin-Like Receptor-1 3
  • C-Type Lectin-Like Receptor 1 4

External Ids for CLEC1A Gene

Previous GeneCards Identifiers for CLEC1A Gene

  • GC12M010115
  • GC12M010222
  • GC12M009965
  • GC12M010271
  • GC12M010610
  • GC12M010769
  • GC12M011007

Summaries for CLEC1A Gene

Entrez Gene Summary for CLEC1A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for CLEC1A Gene

CLEC1A (C-Type Lectin Domain Family 1 Member A) is a Protein Coding gene. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLEC12B.

Gene Wiki entry for CLEC1A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC1A Gene

Genomics for CLEC1A Gene

Regulatory Elements for CLEC1A Gene

Enhancers for CLEC1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F010030 0.9 Ensembl ENCODE 6.8 +80.1 80059 2.7 STAT1 JUN BHLHE40 MAFG ARID1B MAFF POLR2A KDM1A FOS NFE2 CLEC7A CLEC12B TMEM52B OLR1 CLEC1A STYK1 CLEC9A LOC100421202
GH12F010096 0.7 Ensembl ENCODE 8.7 +13.4 13363 3.0 POLR2A ZNF610 JUNB CLEC1A CLEC7A GC12P010105 RN7SKP161
GH12F010089 0.7 Ensembl 7.8 +21.7 21727 1.4 MTA2 BHLHE40 JUNB TBX21 ATF2 EP300 RELA ZFHX2 RAD51 EED CLEC7A CLEC1A RN7SKP161 GC12P010105
GH12F010100 0.7 Ensembl ENCODE 5.1 +9.9 9854 2.4 ZFHX2 RFX1 FEZF1 CLEC7A LOC100506159 CLEC1A MAGOHB GC12P010105 RN7SKP161
GH12F010094 0.4 Ensembl 8.6 +16.5 16527 1.0 SMARCA4 CLEC1A GC12P010105 RN7SKP161
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLEC1A on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC1A Gene

Chromosome:
12
Start:
10,069,504 bp from pter
End:
10,111,627 bp from pter
Size:
42,124 bases
Orientation:
Minus strand

Genomic View for CLEC1A Gene

Genes around CLEC1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC1A Gene

Proteins for CLEC1A Gene

  • Protein details for CLEC1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC01-CLC1A_HUMAN
    Recommended name:
    C-type lectin domain family 1 member A
    Protein Accession:
    Q8NC01
    Secondary Accessions:
    • Q8IUW7
    • Q9NZH3

    Protein attributes for CLEC1A Gene

    Size:
    280 amino acids
    Molecular mass:
    31952 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC1A Gene

Post-translational modifications for CLEC1A Gene

  • Glycosylation at Asn 95 and Asn 169
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLEC1A Gene

Domains & Families for CLEC1A Gene

Gene Families for CLEC1A Gene

Protein Domains for CLEC1A Gene

Graphical View of Domain Structure for InterPro Entry

Q8NC01

UniProtKB/Swiss-Prot:

CLC1A_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC1A: view

Function for CLEC1A Gene

Gene Ontology (GO) - Molecular Function for CLEC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10671229
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC1A: view

Phenotypes for CLEC1A Gene

genes like me logo Genes that share phenotypes with CLEC1A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC1A

miRNA for CLEC1A Gene

miRTarBase miRNAs that target CLEC1A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC1A Gene

Localization for CLEC1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC1A Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC1A gene
Compartment Confidence
plasma membrane 4
extracellular 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CLEC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 10671229
GO:0005887 integral component of plasma membrane TAS 10671229
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC1A: view

Pathways & Interactions for CLEC1A Gene

SuperPathways for CLEC1A Gene

No Data Available

Interacting Proteins for CLEC1A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000326407%0d%0a9606.ENSP00000264606%0d%0a
Selected Interacting proteins: ENSP00000326407 Q8NC01-CLC1A_HUMAN for CLEC1A Gene via STRING IID

Gene Ontology (GO) - Biological Process for CLEC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 10671229
GO:0007166 cell surface receptor signaling pathway TAS 10671229
genes like me logo Genes that share ontologies with CLEC1A: view

No data available for Pathways by source and SIGNOR curated interactions for CLEC1A Gene

Transcripts for CLEC1A Gene

Unigene Clusters for CLEC1A Gene

C-type lectin domain family 1, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: -
SP3: -
SP4: - - -
SP5: - - - -

Relevant External Links for CLEC1A Gene

GeneLoc Exon Structure for
CLEC1A
ECgene alternative splicing isoforms for
CLEC1A

Expression for CLEC1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLEC1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC1A Gene

This gene is overexpressed in Lung (x4.0).

Protein differential expression in normal tissues from HIPED for CLEC1A Gene

This gene is overexpressed in Cerebral cortex (46.7) and Placenta (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC1A Gene



Protein tissue co-expression partners for CLEC1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLEC1A Gene:

CLEC1A

SOURCE GeneReport for Unigene cluster for CLEC1A Gene:

Hs.29549

mRNA Expression by UniProt/SwissProt for CLEC1A Gene:

Q8NC01-CLC1A_HUMAN
Tissue specificity: Expressed preferentially in dendritic cells.
genes like me logo Genes that share expression patterns with CLEC1A: view

Orthologs for CLEC1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC1A 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia CLEC1A 34
  • 83.33 (n)
cow
(Bos Taurus)
Mammalia CLEC1A 34 35
  • 81.13 (n)
mouse
(Mus musculus)
Mammalia Clec1a 34 16 35
  • 76.95 (n)
rat
(Rattus norvegicus)
Mammalia Clec1a 34
  • 76.95 (n)
oppossum
(Monodelphis domestica)
Mammalia CLEC1A 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 33 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 39 (a)
OneToMany
Species where no ortholog for CLEC1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC1A Gene

ENSEMBL:
Gene Tree for CLEC1A (if available)
TreeFam:
Gene Tree for CLEC1A (if available)

Paralogs for CLEC1A Gene

Paralogs for CLEC1A Gene

(8) SIMAP similar genes for CLEC1A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CLEC1A Gene

genes like me logo Genes that share paralogs with CLEC1A: view

Variants for CLEC1A Gene

Sequence variations from dbSNP and Humsavar for CLEC1A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10505753 -- 10,093,121(+) TCTAA(C/T)GTTTC intron-variant
rs10706436 -- 10,098,658(+) AACTG(-/A)AAAAA intron-variant
rs10743868 -- 10,069,153(+) GTCTA(C/T)ACTTG downstream-variant-500B
rs10772231 -- 10,083,072(+) TGGAG(A/C)CTGGT intron-variant
rs10772233 -- 10,086,246(+) AAAAC(C/T)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC1A Gene

Variant ID Type Subtype PubMed ID
nsv826239 CNV loss 20364138
esv3628525 CNV loss 21293372
esv3628524 CNV loss 21293372
esv3548742 CNV deletion 23714750
esv2745532 CNV deletion 23290073
esv2431271 CNV insertion 19546169
esv2275947 CNV deletion 18987734
esv1181821 CNV insertion 17803354

Variation tolerance for CLEC1A Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC1A Gene

Disorders for CLEC1A Gene

Relevant External Links for CLEC1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC1A

No disorders were found for CLEC1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC1A Gene

Publications for CLEC1A Gene

  1. Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. (PMID: 10671229) Colonna M. … Angman L. (Eur. J. Immunol. 2000) 2 3 4 22 64
  2. A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. (PMID: 11745369) Sobanov Y. … Hofer E. (Eur. J. Immunol. 2001) 2 3 22 64
  3. Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells. (PMID: 17046204) Kanazawa N. (J. Dermatol. Sci. 2007) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CLEC1A Gene

Sources for CLEC1A Gene

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