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Aliases for CLEC1A Gene

Aliases for CLEC1A Gene

  • C-Type Lectin Domain Family 1, Member A 2 3
  • CLEC1 3 4 6
  • CLEC-1 3 4
  • C-Type Lectin Domain Family 1 Member A 3
  • C-Type Lectin-Like Receptor-1 3
  • C-Type Lectin-Like Receptor 1 4

External Ids for CLEC1A Gene

Previous GeneCards Identifiers for CLEC1A Gene

  • GC12M010115
  • GC12M010222
  • GC12M009965

Summaries for CLEC1A Gene

Entrez Gene Summary for CLEC1A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for CLEC1A Gene

CLEC1A (C-Type Lectin Domain Family 1, Member A) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding and transmembrane signaling receptor activity. An important paralog of this gene is CLEC7A.

Gene Wiki entry for CLEC1A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC1A Gene

Genomics for CLEC1A Gene

Regulatory Elements for CLEC1A Gene

Genomic Location for CLEC1A Gene

Start:
10,069,554 bp from pter
End:
10,111,627 bp from pter
Size:
42,074 bases
Orientation:
Minus strand

Genomic View for CLEC1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC1A Gene

Proteins for CLEC1A Gene

  • Protein details for CLEC1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC01-CLC1A_HUMAN
    Recommended name:
    C-type lectin domain family 1 member A
    Protein Accession:
    Q8NC01
    Secondary Accessions:
    • Q8IUW7
    • Q9NZH3

    Protein attributes for CLEC1A Gene

    Size:
    280 amino acids
    Molecular mass:
    31952 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC1A Gene

Proteomics data for CLEC1A Gene at MOPED

Post-translational modifications for CLEC1A Gene

  • Glycosylation at Asn95 and Asn169
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CLEC1A Gene

Domains for CLEC1A Gene

Gene Families for CLEC1A Gene

HGNC:
  • CLEC :C-type lectin domain containing

Protein Domains for CLEC1A Gene

Graphical View of Domain Structure for InterPro Entry

Q8NC01

UniProtKB/Swiss-Prot:

CLC1A_HUMAN :
  • Q8NC01
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC1A: view

Function for CLEC1A Gene

Gene Ontology (GO) - Molecular Function for CLEC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10671229
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC1A: view

Phenotypes for CLEC1A Gene

GenomeRNAi human phenotypes for CLEC1A:
genes like me logo Genes that share phenotypes with CLEC1A: view

Animal Model Products

CRISPR Products

miRNA for CLEC1A Gene

miRTarBase miRNAs that target CLEC1A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC1A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLEC1A Gene

Localization for CLEC1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC1A Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC1A Gene COMPARTMENTS Subcellular localization image for CLEC1A gene
Compartment Confidence
plasma membrane 4
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLEC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 10671229
GO:0005887 integral component of plasma membrane TAS 10671229
genes like me logo Genes that share ontologies with CLEC1A: view

Pathways for CLEC1A Gene

SuperPathways for CLEC1A Gene

No Data Available

Interacting Proteins for CLEC1A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000326407%0d%0a9606.ENSP00000264606%0d%0a
Selected Interacting proteins: ENSP00000326407 for CLEC1A Gene via STRING

Symbol External ID(s) Details
HDAC4

Gene Ontology (GO) - Biological Process for CLEC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 10671229
GO:0007166 cell surface receptor signaling pathway TAS 10671229
genes like me logo Genes that share ontologies with CLEC1A: view

No data available for Pathways by source for CLEC1A Gene

Transcripts for CLEC1A Gene

Unigene Clusters for CLEC1A Gene

C-type lectin domain family 1, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC1A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: -
SP3: -
SP4: - - -
SP5: - - - -

Relevant External Links for CLEC1A Gene

GeneLoc Exon Structure for
CLEC1A
ECgene alternative splicing isoforms for
CLEC1A

Expression for CLEC1A Gene

mRNA expression in normal human tissues for CLEC1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC1A Gene

This gene is overexpressed in Lung (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CLEC1A Gene

SOURCE GeneReport for Unigene cluster for CLEC1A Gene Hs.29549

mRNA Expression by UniProt/SwissProt for CLEC1A Gene

Q8NC01-CLC1A_HUMAN
Tissue specificity: Expressed preferentially in dendritic cells.
genes like me logo Genes that share expressions with CLEC1A: view

In Situ Assay Products

Orthologs for CLEC1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC1A 35
  • 99.64 (n)
  • 99.29 (a)
CLEC1A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLEC1A 35
  • 81.13 (n)
  • 75.74 (a)
CLEC1A 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC1A 35
  • 83.33 (n)
  • 74.81 (a)
mouse
(Mus musculus)
Mammalia Clec1a 35
  • 76.95 (n)
  • 69.89 (a)
Clec1a 16
Clec1a 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLEC1A 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Clec1a 35
  • 76.95 (n)
  • 71.38 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
Species with no ortholog for CLEC1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC1A Gene

ENSEMBL:
Gene Tree for CLEC1A (if available)
TreeFam:
Gene Tree for CLEC1A (if available)

Paralogs for CLEC1A Gene

Paralogs for CLEC1A Gene

Selected SIMAP similar genes for CLEC1A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CLEC1A Gene

genes like me logo Genes that share paralogs with CLEC1A: view

Variants for CLEC1A Gene

Sequence variations from dbSNP and Humsavar for CLEC1A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs725079 -- 10,072,431(-) TAGTC(A/G)TACAT intron-variant
rs952545 -- 10,094,454(-) CAATA(C/T)TCTCC intron-variant
rs952546 -- 10,094,112(-) GAAGA(G/T)GAAAA intron-variant
rs1352477 -- 10,088,994(+) CATTT(A/G/T)AAAAA intron-variant
rs1387140 -- 10,094,481(+) AAATA(A/G)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC1A Gene

Variant ID Type Subtype PubMed ID
nsv898757 CNV Gain 21882294
esv2431271 CNV Insertion 19546169
esv271248 CNV Insertion 20981092
esv273949 CNV Insertion 20981092
esv1181821 CNV Insertion 17803354
esv2275947 CNV Deletion 18987734
nsv826239 CNV Loss 20364138
esv2745532 CNV Deletion 23290073

Relevant External Links for CLEC1A Gene

HapMap Linkage Disequilibrium report
CLEC1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC1A Gene

Disorders for CLEC1A Gene

No disorders were found for CLEC1A Gene.

No data available for UniProtKB/Swiss-Prot for CLEC1A Gene

Publications for CLEC1A Gene

  1. Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. (PMID: 10671229) Colonna M. … Angman L. (Eur. J. Immunol. 2000) 2 3 4 23
  2. A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. (PMID: 11745369) Sobanov Y. … Hofer E. (Eur. J. Immunol. 2001) 2 3 23
  3. Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells. (PMID: 17046204) Kanazawa N. (J. Dermatol. Sci. 2007) 3 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CLEC1A Gene

  • antibodies-online proteins for CLEC1A
  • antibodies-online antibodies for CLEC1A
  • antibodies-online kits for CLEC1A

Sources for CLEC1A Gene

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