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Aliases for CLEC18C Gene

Aliases for CLEC18C Gene

  • C-Type Lectin Domain Family 18 Member C 2 3 5
  • C-Type Lectin Domain Family 18, Member C 2 3
  • Mannose Receptor-Like Protein 3 3 4
  • Mannose Receptor-Like 3 3
  • MRCL3 3
  • MRLP3 4
  • MRCL 3

External Ids for CLEC18C Gene

Previous GeneCards Identifiers for CLEC18C Gene

  • GC16P068767
  • GC16P070207
  • GC16M060201

Summaries for CLEC18C Gene

GeneCards Summary for CLEC18C Gene

CLEC18C (C-Type Lectin Domain Family 18 Member C) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot for CLEC18C Gene

  • Binds polysaccharidesin a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC18C Gene

Genomics for CLEC18C Gene

Regulatory Elements for CLEC18C Gene

Enhancers for CLEC18C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLEC18C on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC18C Gene

70,173,322 bp from pter
70,187,361 bp from pter
14,040 bases
Plus strand

Genomic View for CLEC18C Gene

Genes around CLEC18C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC18C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC18C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC18C Gene

Proteins for CLEC18C Gene

  • Protein details for CLEC18C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 18 member C
    Protein Accession:
    Secondary Accessions:
    • Q8IUW8

    Protein attributes for CLEC18C Gene

    446 amino acids
    Molecular mass:
    49585 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH39068.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CLEC18C Gene


neXtProt entry for CLEC18C Gene

Proteomics data for CLEC18C Gene at MOPED

Post-translational modifications for CLEC18C Gene

  • Glycosylation at Asn 144
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLEC18C Gene

Domains & Families for CLEC18C Gene

Gene Families for CLEC18C Gene

Suggested Antigen Peptide Sequences for CLEC18C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 SCP domain.
genes like me logo Genes that share domains with CLEC18C: view

Function for CLEC18C Gene

Molecular function for CLEC18C Gene

UniProtKB/Swiss-Prot Function:
Binds polysaccharidesin a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.

Phenotypes for CLEC18C Gene

GenomeRNAi human phenotypes for CLEC18C:
genes like me logo Genes that share phenotypes with CLEC18C: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC18C Gene

Localization for CLEC18C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC18C Gene

Secreted. Endoplasmic reticulum. Golgi apparatus. Endosome.

Subcellular locations from

Jensen Localization Image for CLEC18C Gene COMPARTMENTS Subcellular localization image for CLEC18C gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
extracellular 5
golgi apparatus 5
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CLEC18C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005768 endosome TAS 26170455
genes like me logo Genes that share ontologies with CLEC18C: view

Pathways & Interactions for CLEC18C Gene

SuperPathways for CLEC18C Gene

No Data Available

Interacting Proteins for CLEC18C Gene

Gene Ontology (GO) - Biological Process for CLEC18C Gene


No data available for Pathways by source and SIGNOR curated interactions for CLEC18C Gene

Drugs & Compounds for CLEC18C Gene

No Compound Related Data Available

Transcripts for CLEC18C Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC18C Gene

No ASD Table

Relevant External Links for CLEC18C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC18C Gene

mRNA expression in normal human tissues for CLEC18C Gene

mRNA differential expression in normal tissues according to GTEx for CLEC18C Gene

This gene is overexpressed in Kidney - Cortex (x30.0) and Testis (x6.2).

mRNA Expression by UniProt/SwissProt for CLEC18C Gene

Tissue specificity: Detected in peripheral blood cells.
genes like me logo Genes that share expression patterns with CLEC18C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CLEC18C Gene

Orthologs for CLEC18C Gene

This gene was present in the common ancestor of animals.

Orthologs for CLEC18C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRCL 36
  • 46 (a)
(Canis familiaris)
Mammalia -- 36
  • 68 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
(Mus musculus)
Mammalia Clec18a 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
(Gallus gallus)
Aves -- 36
  • 64 (a)
(Caenorhabditis elegans)
Secernentea lon-1 36
  • 23 (a)
Species with no ortholog for CLEC18C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CLEC18C Gene

Gene Tree for CLEC18C (if available)
Gene Tree for CLEC18C (if available)

Paralogs for CLEC18C Gene

(3) SIMAP similar genes for CLEC18C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CLEC18C: view

Variants for CLEC18C Gene

Sequence variations from dbSNP and Humsavar for CLEC18C Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3869428 -- 70,177,467(+) CTGCA(C/G)CCACT intron-variant, reference, missense
rs3869429 -- 70,177,477(+) TACAC(A/G)CAGGT intron-variant, reference, synonymous-codon
rs3874522 -- 70,175,767(+) GCCAC(A/G)GTGGC intron-variant
rs61304623 -- 70,181,369(+) TAGGC(C/T)GGGCA intron-variant
rs61373963 -- 70,181,437(+) GAGGT(C/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC18C Gene

Variant ID Type Subtype PubMed ID
dgv895e1 CNV Complex 17122850
nsv1853 CNV Loss 18451855
dgv2892n71 CNV Gain 21882294
dgv2893n71 CNV Gain 21882294
dgv485n67 CNV Loss 20364138
nsv428328 CNV Gain+Loss 18775914
nsv436059 CNV Insertion 17901297
esv2657437 CNV Deletion 23128226
nsv833269 CNV Loss 17160897
nsv820087 CNV Loss 19587683
nsv469646 CNV Gain 16826518
nsv471695 CNV Loss 15918152
dgv2899n71 CNV Gain 21882294
esv33745 CNV Gain+Loss 17666407
dgv896e1 CNV Complex 17122850
dgv2901n71 CNV Gain 21882294
nsv9455 CNV Gain+Loss 18304495
esv25519 CNV Gain+Loss 19812545
nsv827728 CNV Loss 20364138
esv1007882 CNV Loss 20482838
nsv7285 OTHER Inversion 18451855
dgv2902n71 CNV Gain 21882294
nsv906866 CNV Gain 21882294
nsv833271 CNV Gain+Loss 17160897
nsv906867 CNV Gain 21882294
nsv482196 CNV Gain 20164927

Variation tolerance for CLEC18C Gene

Gene Damage Index Score: 2.82; 47.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CLEC18C Gene

Disorders for CLEC18C Gene

Relevant External Links for CLEC18C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLEC18C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC18C Gene

Publications for CLEC18C Gene

  1. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. (PMID: 26170455) Huang Y.L. … Hsieh S.L. (J. Biol. Chem. 2015) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. The C-type lectin-like domain superfamily. (PMID: 16336259) Zelensky A.N. … Gready J.E. (FEBS J. 2005) 3

Products for CLEC18C Gene

Sources for CLEC18C Gene