CLEC18C Gene
protein-coding GIFtS: 37
GCID: GC16P070207
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C-type lectin domain family 18, member C
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Aliases
for CLEC18C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| C-Type Lectin Domain Family 18, Member C1 2 | | MRCL32 | | Mannose Receptor-Like Protein 32 3 | | C-Type Lectin Domain Family 18 Member C2 | | MGC347611 | | Mannose Receptor-Like 32 | | MRCL2 | | MRLP33 |
Export aliases for CLEC18C gene to outside databasesPrevious GC identifers: GC16P068767 GC16M060201 |
Summaries
for CLEC18C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CLEC18C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLEC18C gene promoter:
ER-alpha Tal-1 AML1a Pax-5 Olf-1 STAT5A C/EBPalpha AREB6 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLEC18C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC18C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1CLEC18C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P070207: view genomic region
(about GC identifiers)
Start:
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70,207,225 bp from pter |
End:
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70,221,264 bp from pter |
Size:
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14,040 bases |
Orientation:
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plus strand |
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Proteins
for CLEC18C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CL18C_HUMAN, Q8NCF0 (See
protein sequence)Recommended Name: C-type lectin domain family 18 member C precursor Size: 446 amino acids; 49585 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=AAH39068.1; Type=Erroneous initiation;
Secondary accessions: Q8IUW8Alternative splicing: 2 isoforms: Q8NCF0-1 Q8NCF0-2 Explore the universe of human proteins at neXtProt for CLEC18C: NX_Q8NCF0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NCF0
CLEC18C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775890.2
ENSEMBL proteins: ENSP00000456676 ENSP00000444875 ENSP00000326538 ENSP00000457584 ENSP00000455920 ENSP00000444726
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CLEC18C for ontologies About GeneDecksing
CLEC18C Antibody Products:
Assay Products for CLEC18C: |
Protein
Domains /
Families
for CLEC18C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLEC18C for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q8NCF0ProtoNet protein and cluster: Q8NCF0 UniProtKB/Swiss-Prot: CL18C_HUMAN, Q8NCF0Similarity: Contains 1 C-type lectin domainSimilarity: Contains 1 EGF-like domainSimilarity: Contains 1 SCP domain |
Function
for CLEC18C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC18C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC18C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CLEC18C (NM_173619) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLEC18C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC18C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC18C |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030246 | carbohydrate binding |
IEA | -- |
CLEC18C for ontologies About GeneDecksing
|
Pathways & Interactions
for CLEC18C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC18C
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for CLEC18C (ENSP000003265384) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CLEC18C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CLEC18C
Search CenterWatch for drugs/clinical trials and news about CLEC18C / CL18C
|
Transcripts
for CLEC18C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLEC18C gene: NM_173619.2 10 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000562923 ENST00000541793 ENST00000314151 ENST00000565806 ENST00000569347(uc002eyk.3)
ENST00000564976 ENST00000569201 ENST00000569268 ENST00000536907(uc002exy.3)
ENST00000561612
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC18C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC18C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CLEC18C (NM_173619) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLEC18C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC18C |
16 AceView cDNA sequences: BC039068 BC062573 BX280233 AI433291 NM_173619 CD673170 AK074773 BE552150 AL833339 BV205319 BI762690 AI522123 BI764403 BI757380 AF448856 AL040183
GeneLoc Exon Structure
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Expression
for CLEC18C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLEC18C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CLEC18C Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for CLEC18C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC18C
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CLEC18C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC18C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC18C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC18C |
Orthologs
for CLEC18C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CLEC18C gene from 3/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC4311371 |
C-type lectin domain family 18 member A-like |
71.44(n)
67.61(a) |
|
431137 XM_428688.3 XP_428688.3 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG84836 |
-- |
15(a) |
1 → many |
3R(9034470-9040187) |
worm
(Caenorhabditis elegans) |
Secernentea |
lon-16 |
Protein lon-1 |
18(a) |
1 → many |
III(5474437-5478343) |
ENSEMBL Gene Tree for CLEC18C (if available)
TreeFam Gene Tree for CLEC18C (if available) |
Paralogs
for CLEC18C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLEC18C gene
- CLEC18A1 2 CLEC18B1 2 CRISPLD22 PI162 GLIPR12 CRISP22 PI152 CRISP12
- CRISPLD12 CRISP32 GLIPR1L12 GLIPR1L22 R3HDML2
3 SIMAP similar genes for CLEC18C using alignment to 4 protein entries: CL18C_HUMAN (see all proteins):CLEC18A CLEC18B GLIPR1L1
CLEC18C for paralogs About GeneDecksing
|
Genomic Variants
for CLEC18C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLEC18C (70207225 - 70221264 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for CLEC18C
15 CNVs: 4964 88194 7125 2216 72609 88193 77399 4963 77400 4009 32131 30786 0797 72607 58772 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC18C |
|
Disorders
/ Diseases
for CLEC18C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLEC18C for disorders About GeneDecksing
1  disease for CLEC18C: About MalaCardsliposarcoma
1 disease from the University of Copenhagen DISEASES database for CLEC18C:Liposarcoma Export disorders for CLEC18C gene to outside databases
|
Publications
for CLEC18C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLEC18C gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLEC18C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The C-type lectin-like domain superfamily. (PubMed id 16336259)1 Zelensky A.N. and Gready J.E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for CLEC18C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CLEC18C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLEC18C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLEC18C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLEC18C | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CLEC18C gene:
Search GeneIP for patents involving CLEC18C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLEC18C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLEC18C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC18C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC18C | | | OriGene Protein Over-expression Lysate for CLEC18C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLEC18C | | OriGene 3'-UTR Clone for CLEC18C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC18C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC18C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLEC18C | | OriGene Custom Protein Services for CLEC18C | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLEC18C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC18C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC18C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC18C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC18C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC18C |
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 |  |  |  | |
| | | | Search Tocris compounds for CLEC18C |
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 | | | CLEC18C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC18C |
|  |  |  | | | | Search ThermoFisher Antibodies for CLEC18C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC18C |
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