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Aliases for CLEC18C Gene

Aliases for CLEC18C Gene

  • C-Type Lectin Domain Family 18 Member C 2 3 5
  • Mannose Receptor-Like Protein 3 3 4
  • C-Type Lectin Domain Family 18, Member C 2
  • Mannose Receptor-Like 3 3
  • MRCL3 3
  • MRLP3 4
  • MRCL 3

External Ids for CLEC18C Gene

Previous GeneCards Identifiers for CLEC18C Gene

  • GC16P068767
  • GC16P070207
  • GC16M060201

Summaries for CLEC18C Gene

GeneCards Summary for CLEC18C Gene

CLEC18C (C-Type Lectin Domain Family 18 Member C) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC18A.

UniProtKB/Swiss-Prot for CLEC18C Gene

  • Binds polysaccharidesin a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC18C Gene

Genomics for CLEC18C Gene

Regulatory Elements for CLEC18C Gene

Enhancers for CLEC18C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F069796 1 Ensembl ENCODE 10.2 -376.7 -376693 0.6 MLX ARID4B DMAP1 SLC30A9 ZNF143 NFYC ZHX2 MXD4 MIER2 REST CLEC18C NQO1 ENSG00000252443 GC16P069921
GH16F069761 1.1 FANTOM5 ENCODE 8.5 -410.7 -410722 2.8 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF143 FOS EXOSC6 NQO1 WWP2 ENSG00000252443 CLEC18C PDXDC2P
GH16F069520 0.6 ENCODE 7.1 -652.0 -652030 1.5 CBX3 ARID4B RAD21 ZNF121 THAP11 KLF11 YY2 USF2 CEBPB ZNF589 CYB5B WWP2 ENSG00000252443 CLEC18A CLEC18C PDXDC2P NPIPB14P LOC105371325 GC16M069496
GH16F069889 0.6 Ensembl ENCODE 6.5 -282.6 -282595 2.2 PKNOX1 YY2 ZBTB8A ZNF518A YY1 KAT2B ZNF610 SMARCA4 HMBOX1 TRIM28 NPIPB14P ENSG00000252443 WWP2 CLEC18C GC16P069921
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CLEC18C on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC18C Gene

70,173,322 bp from pter
70,187,361 bp from pter
14,040 bases
Plus strand

Genomic View for CLEC18C Gene

Genes around CLEC18C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC18C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC18C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC18C Gene

Proteins for CLEC18C Gene

  • Protein details for CLEC18C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 18 member C
    Protein Accession:
    Secondary Accessions:
    • Q8IUW8

    Protein attributes for CLEC18C Gene

    446 amino acids
    Molecular mass:
    49585 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH39068.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CLEC18C Gene


neXtProt entry for CLEC18C Gene

Post-translational modifications for CLEC18C Gene

  • Glycosylation at Asn 144
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLEC18C Gene

Domains & Families for CLEC18C Gene

Gene Families for CLEC18C Gene

Suggested Antigen Peptide Sequences for CLEC18C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 SCP domain.
genes like me logo Genes that share domains with CLEC18C: view

Function for CLEC18C Gene

Molecular function for CLEC18C Gene

UniProtKB/Swiss-Prot Function:
Binds polysaccharidesin a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.

Gene Ontology (GO) - Molecular Function for CLEC18C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
GO:0030247 polysaccharide binding IDA 26170455
genes like me logo Genes that share ontologies with CLEC18C: view

Phenotypes for CLEC18C Gene

GenomeRNAi human phenotypes for CLEC18C:
genes like me logo Genes that share phenotypes with CLEC18C: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC18C Gene

Localization for CLEC18C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC18C Gene

Secreted. Endoplasmic reticulum. Golgi apparatus. Endosome.

Subcellular locations from

Jensen Localization Image for CLEC18C Gene COMPARTMENTS Subcellular localization image for CLEC18C gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
extracellular 5
golgi apparatus 5
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CLEC18C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005768 endosome TAS 26170455
GO:0005783 endoplasmic reticulum TAS 26170455
GO:0005794 Golgi apparatus TAS 26170455
genes like me logo Genes that share ontologies with CLEC18C: view

Pathways & Interactions for CLEC18C Gene

SuperPathways for CLEC18C Gene

No Data Available

Interacting Proteins for CLEC18C Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)
Selected Interacting proteins: Q8NCF0-CL18C_HUMAN ENSP00000326538 for CLEC18C Gene via IID STRING

Gene Ontology (GO) - Biological Process for CLEC18C Gene


No data available for Pathways by source and SIGNOR curated interactions for CLEC18C Gene

Transcripts for CLEC18C Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC18C Gene

No ASD Table

Relevant External Links for CLEC18C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC18C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLEC18C Gene

mRNA differential expression in normal tissues according to GTEx for CLEC18C Gene

This gene is overexpressed in Kidney - Cortex (x30.0) and Testis (x6.2).

NURSA nuclear receptor signaling pathways regulating expression of CLEC18C Gene:


mRNA Expression by UniProt/SwissProt for CLEC18C Gene:

Tissue specificity: Detected in peripheral blood cells.
genes like me logo Genes that share expression patterns with CLEC18C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CLEC18C Gene

Orthologs for CLEC18C Gene

This gene was present in the common ancestor of animals.

Orthologs for CLEC18C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 95 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
(Canis familiaris)
Mammalia -- 35
  • 68 (a)
(Mus musculus)
Mammalia Clec18a 35
  • 62 (a)
(Bos Taurus)
Mammalia MRCL 35
  • 46 (a)
(Gallus gallus)
Aves -- 35
  • 64 (a)
(Caenorhabditis elegans)
Secernentea lon-1 35
  • 23 (a)
Species where no ortholog for CLEC18C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CLEC18C Gene

Gene Tree for CLEC18C (if available)
Gene Tree for CLEC18C (if available)

Paralogs for CLEC18C Gene

(3) SIMAP similar genes for CLEC18C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CLEC18C: view

Variants for CLEC18C Gene

Sequence variations from dbSNP and Humsavar for CLEC18C Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11075760 -- 70,187,410(+) TTTTT(C/T)TTTTT downstream-variant-500B, upstream-variant-2KB
rs111343091 -- 70,173,897(+) AGGAC(A/G)CGGCC intron-variant, upstream-variant-2KB
rs111865590 -- 70,172,097(+) GACCT(C/T)AAGTG intron-variant, upstream-variant-2KB
rs112115254 -- 70,175,886(+) AGGCT(C/T)AGACC intron-variant
rs112457395 -- 70,175,895(+) CCCTG(C/G)GCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC18C Gene

Variant ID Type Subtype PubMed ID
dgv1365n106 CNV duplication 24896259
dgv25e213 CNV gain 24956385
dgv2998n100 CNV gain 25217958
dgv3005n100 CNV gain+loss 25217958
dgv3006n100 CNV loss 25217958
dgv3011n100 CNV gain+loss 25217958
dgv3012n100 CNV loss 25217958
dgv3013n100 CNV gain 25217958
dgv485n67 CNV loss 20364138
dgv849e212 CNV gain 25503493
dgv851e212 CNV loss 25503493
esv1007882 CNV loss 20482838
esv25519 CNV gain+loss 19812545
esv2657437 CNV deletion 23128226
esv2758652 CNV gain+loss 17122850
esv2760404 CNV gain+loss 21179565
esv2762188 CNV gain+loss 21179565
esv3344778 CNV duplication 20981092
esv33745 CNV gain+loss 17666407
nsv1058068 CNV gain+loss 25217958
nsv1060953 CNV gain 25217958
nsv1062268 CNV gain+loss 25217958
nsv1146597 CNV duplication 26484159
nsv1148716 CNV duplication 26484159
nsv1853 CNV deletion 18451855
nsv428328 CNV gain+loss 18775914
nsv436059 CNV insertion 17901297
nsv469646 CNV gain 16826518
nsv471695 CNV loss 15918152
nsv482196 CNV gain 20164927
nsv572916 CNV loss 21841781
nsv7285 OTHER inversion 18451855
nsv820087 CNV loss 19587683
nsv827728 CNV loss 20364138
nsv833269 CNV loss 17160897
nsv833271 CNV gain+loss 17160897
nsv9455 CNV gain+loss 18304495
nsv977993 CNV duplication 23825009

Variation tolerance for CLEC18C Gene

Gene Damage Index Score: 2.82; 47.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC18C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC18C Gene

Disorders for CLEC18C Gene

Relevant External Links for CLEC18C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLEC18C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC18C Gene

Publications for CLEC18C Gene

  1. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. (PMID: 26170455) Huang Y.L. … Hsieh S.L. (J. Biol. Chem. 2015) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  4. The C-type lectin-like domain superfamily. (PMID: 16336259) Zelensky A.N. … Gready J.E. (FEBS J. 2005) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for CLEC18C Gene

Sources for CLEC18C Gene

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