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Aliases for CLEC18B Gene

Aliases for CLEC18B Gene

  • C-Type Lectin Domain Family 18 Member B 2 3 5
  • C-Type Lectin Domain Family 18, Member B 2 3
  • Mannose Receptor-Like Protein 1 3 4
  • Secretory Protein LOC497190 3
  • Mannose Receptor-Like 2 3
  • MRCL2 3
  • MRLP1 4

External Ids for CLEC18B Gene

Previous GeneCards Identifiers for CLEC18B Gene

  • GC16M073002

Summaries for CLEC18B Gene

GeneCards Summary for CLEC18B Gene

CLEC18B (C-Type Lectin Domain Family 18 Member B) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is GLIPR1L2.

UniProtKB/Swiss-Prot for CLEC18B Gene

  • Binds polysaccharides in a Ca(2+)-independent manner (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC18B Gene

Genomics for CLEC18B Gene

Regulatory Elements for CLEC18B Gene

Enhancers for CLEC18B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLEC18B on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC18B Gene

74,408,270 bp from pter
74,422,248 bp from pter
13,979 bases
Minus strand

Genomic View for CLEC18B Gene

Genes around CLEC18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC18B Gene

Proteins for CLEC18B Gene

  • Protein details for CLEC18B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 18 member B
    Protein Accession:
    Secondary Accessions:
    • B4DF90

    Protein attributes for CLEC18B Gene

    455 amino acids
    Molecular mass:
    50490 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLEC18B Gene


neXtProt entry for CLEC18B Gene

Proteomics data for CLEC18B Gene at MOPED

Post-translational modifications for CLEC18B Gene

Other Protein References for CLEC18B Gene

No data available for DME Specific Peptides for CLEC18B Gene

Domains & Families for CLEC18B Gene

Gene Families for CLEC18B Gene

Suggested Antigen Peptide Sequences for CLEC18B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 SCP domain.
genes like me logo Genes that share domains with CLEC18B: view

Function for CLEC18B Gene

Molecular function for CLEC18B Gene

UniProtKB/Swiss-Prot Function:
Binds polysaccharides in a Ca(2+)-independent manner (By similarity).

Phenotypes for CLEC18B Gene

GenomeRNAi human phenotypes for CLEC18B:
genes like me logo Genes that share phenotypes with CLEC18B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC18B Gene

Localization for CLEC18B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC18B Gene

Secreted. Endoplasmic reticulum. Golgi apparatus. Endosome.

Subcellular locations from

Jensen Localization Image for CLEC18B Gene COMPARTMENTS Subcellular localization image for CLEC18B gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
extracellular 5
golgi apparatus 5
plasma membrane 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLEC18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005768 endosome TAS 26170455
genes like me logo Genes that share ontologies with CLEC18B: view

Pathways & Interactions for CLEC18B Gene

SuperPathways for CLEC18B Gene

No Data Available

Interacting Proteins for CLEC18B Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000341051 for CLEC18B Gene via STRING

Gene Ontology (GO) - Biological Process for CLEC18B Gene


No data available for Pathways by source and SIGNOR curated interactions for CLEC18B Gene

Drugs & Compounds for CLEC18B Gene

No Compound Related Data Available

Transcripts for CLEC18B Gene

mRNA/cDNA for CLEC18B Gene

(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC18B Gene

C-type lectin domain family 18, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC18B Gene

No ASD Table

Relevant External Links for CLEC18B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC18B Gene

mRNA expression in normal human tissues for CLEC18B Gene

mRNA differential expression in normal tissues according to GTEx for CLEC18B Gene

This gene is overexpressed in Kidney - Cortex (x21.8) and Testis (x4.3).

SOURCE GeneReport for Unigene cluster for CLEC18B Gene Hs.454670

genes like me logo Genes that share expression patterns with CLEC18B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CLEC18B Gene

Orthologs for CLEC18B Gene

This gene was present in the common ancestor of animals.

Orthologs for CLEC18B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRCL 35
  • 83.06 (n)
  • 80.38 (a)
  • 46 (a)
(Canis familiaris)
Mammalia CLEC18A 35
  • 85.71 (n)
  • 82.77 (a)
-- 36
  • 68 (a)
(Mus musculus)
Mammalia Clec18a 35
  • 82.58 (n)
  • 80.38 (a)
Clec18a 16
Clec18a 36
  • 63 (a)
(Rattus norvegicus)
Mammalia Clec18a 35
  • 81.92 (n)
  • 80.9 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
(Gallus gallus)
Aves CLEC18A 35
  • 72.4 (n)
  • 69.25 (a)
-- 36
  • 65 (a)
(Caenorhabditis elegans)
Secernentea lon-1 36
  • 23 (a)
Species with no ortholog for CLEC18B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CLEC18B Gene

Gene Tree for CLEC18B (if available)
Gene Tree for CLEC18B (if available)

Paralogs for CLEC18B Gene

(2) SIMAP similar genes for CLEC18B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLEC18B: view

Variants for CLEC18B Gene

Sequence variations from dbSNP and Humsavar for CLEC18B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3863433 -- 74,413,853(-) ataaa(-/TAAA)TAAGC intron-variant
rs3883257 -- 74,414,528(-) TCATG(C/T)GGTGA intron-variant
rs3931745 -- 74,410,262(+) TGGAG(A/G)GATGG intron-variant, downstream-variant-500B
rs3931746 -- 74,410,463(+) GGCAG(C/T)GGGAT intron-variant, downstream-variant-500B
rs4022152 -- 74,421,750(-) TAGCC(A/G)AGGTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLEC18B Gene

Variant ID Type Subtype PubMed ID
dgv2910n71 CNV Gain 21882294
dgv900e1 CNV Complex 17122850
dgv901e1 CNV Complex 17122850
nsv833277 CNV Loss 17160897
esv22159 CNV Gain+Loss 19812545
nsv827736 CNV Gain 20364138
nsv509632 CNV Insertion 20534489
nsv819754 CNV Loss 19587683
nsv9457 CNV Gain+Loss 18304495
dgv488n67 CNV Loss 20364138
dgv2911n71 CNV Gain 21882294
esv32572 CNV Gain 17666407
nsv442726 CNV CNV 18776908
nsv833278 CNV Loss 17160897
nsv821530 CNV Duplication 20802225

Variation tolerance for CLEC18B Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CLEC18B Gene

Disorders for CLEC18B Gene

Relevant External Links for CLEC18B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLEC18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC18B Gene

Publications for CLEC18B Gene

  1. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. (PMID: 26170455) Huang Y.L. … Hsieh S.L. (J. Biol. Chem. 2015) 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. The C-type lectin-like domain superfamily. (PMID: 16336259) Zelensky A.N. … Gready J.E. (FEBS J. 2005) 3
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for CLEC18B Gene

Sources for CLEC18B Gene