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Aliases for CLEC18B Gene

Aliases for CLEC18B Gene

  • C-Type Lectin Domain Family 18 Member B 2 3 5
  • Mannose Receptor-Like Protein 1 3 4
  • Mannose Receptor-Like 2 2 3
  • C-Type Lectin Domain Family 18, Member B 2
  • Secretory Protein LOC497190 3
  • MRCL2 3
  • MRLP1 4

External Ids for CLEC18B Gene

Previous HGNC Symbols for CLEC18B Gene

  • MRCL2

Previous GeneCards Identifiers for CLEC18B Gene

  • GC16M073002

Summaries for CLEC18B Gene

GeneCards Summary for CLEC18B Gene

CLEC18B (C-Type Lectin Domain Family 18 Member B) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC18C.

UniProtKB/Swiss-Prot for CLEC18B Gene

  • Binds polysaccharides in a Ca(2+)-independent manner (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC18B Gene

Genomics for CLEC18B Gene

Regulatory Elements for CLEC18B Gene

Enhancers for CLEC18B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G074479 1.1 Ensembl ENCODE 19.8 -58.2 -58233 2.8 SIN3A FEZF1 RAD21 RFX5 TCF12 EGR2 ZHX2 GATAD2B ZNF843 KLF16 RFWD3 CLEC18B RNU6-237P GC16M074463 ENSG00000207525 RPS10P23
GH16G074600 1.1 Ensembl ENCODE 10 -179.0 -178990 2.0 HNRNPUL1 FOXA2 ARID4B YY1 MIXL1 PAF1 OVOL3 ZHX2 NFIL3 PRDM6 RFWD3 RNU6-237P CLEC18B GLG1 GC16P074552
GH16G074605 1.1 ENCODE 8.2 -185.1 -185140 4.3 HDGF HNRNPUL1 PKNOX1 MLX CREB3L1 AGO1 ARID4B SIN3A FEZF1 DMAP1 RFWD3 ENSG00000259972 RPL21P118 ENSG00000260884 CLEC18B GLG1 HSPE1P7
GH16G074476 0.7 ENCODE 12.1 -55.4 -55374 1.8 SAP130 ZFP64 ZNF426 ZNF394 ZNF623 ZNF781 ZNF518A ZNF697 ZNF555 HNF1A GLG1 RFWD3 CLEC18B ENSG00000260884 RPL21P118 ZFP1 ENSG00000259972 LOC440386 ENSG00000207525 GC16M074463
GH16G074366 1.3 ENCODE dbSUPER 5.9 +54.1 54051 2.4 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 KLF13 SP3 SP5 PSMD7 LOC440386 CLEC18B RFWD3 ENSG00000214331
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLEC18B on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC18B Gene

74,408,270 bp from pter
74,422,248 bp from pter
13,979 bases
Minus strand

Genomic View for CLEC18B Gene

Genes around CLEC18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC18B Gene

Proteins for CLEC18B Gene

  • Protein details for CLEC18B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 18 member B
    Protein Accession:
    Secondary Accessions:
    • B4DF90

    Protein attributes for CLEC18B Gene

    455 amino acids
    Molecular mass:
    50490 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLEC18B Gene


neXtProt entry for CLEC18B Gene

Post-translational modifications for CLEC18B Gene

Other Protein References for CLEC18B Gene

No data available for DME Specific Peptides for CLEC18B Gene

Domains & Families for CLEC18B Gene

Gene Families for CLEC18B Gene

Suggested Antigen Peptide Sequences for CLEC18B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLEC18B: view

No data available for UniProtKB/Swiss-Prot for CLEC18B Gene

Function for CLEC18B Gene

Molecular function for CLEC18B Gene

UniProtKB/Swiss-Prot Function:
Binds polysaccharides in a Ca(2+)-independent manner (By similarity).

Gene Ontology (GO) - Molecular Function for CLEC18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC18B: view

Phenotypes for CLEC18B Gene

GenomeRNAi human phenotypes for CLEC18B:
genes like me logo Genes that share phenotypes with CLEC18B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC18B Gene

Localization for CLEC18B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC18B Gene

Secreted. Endoplasmic reticulum. Golgi apparatus. Endosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC18B gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 5
plasma membrane 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CLEC18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005768 endosome TAS 26170455
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus TAS 26170455
GO:0016529 sarcoplasmic reticulum TAS 26170455
genes like me logo Genes that share ontologies with CLEC18B: view

Pathways & Interactions for CLEC18B Gene

SuperPathways for CLEC18B Gene

No Data Available

Interacting Proteins for CLEC18B Gene

Gene Ontology (GO) - Biological Process for CLEC18B Gene


No data available for Pathways by source and SIGNOR curated interactions for CLEC18B Gene

Drugs & Compounds for CLEC18B Gene

No Compound Related Data Available

Transcripts for CLEC18B Gene

mRNA/cDNA for CLEC18B Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC18B Gene

C-type lectin domain family 18, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC18B Gene

No ASD Table

Relevant External Links for CLEC18B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC18B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLEC18B Gene

mRNA differential expression in normal tissues according to GTEx for CLEC18B Gene

This gene is overexpressed in Kidney - Cortex (x21.8) and Testis (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of CLEC18B Gene:


SOURCE GeneReport for Unigene cluster for CLEC18B Gene:


Evidence on tissue expression from TISSUES for CLEC18B Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CLEC18B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC18B Gene

Orthologs for CLEC18B Gene

This gene was present in the common ancestor of animals.

Orthologs for CLEC18B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 98 (a)
(Canis familiaris)
Mammalia CLEC18A 34
  • 85.71 (n)
-- 35
  • 68 (a)
(Bos Taurus)
Mammalia MRCL 34 35
  • 83.06 (n)
(Mus musculus)
Mammalia Clec18a 34 16 35
  • 82.58 (n)
(Rattus norvegicus)
Mammalia Clec18a 34
  • 81.92 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
(Gallus gallus)
Aves CLEC18A 34
  • 72.4 (n)
-- 35
  • 65 (a)
(Caenorhabditis elegans)
Secernentea lon-1 35
  • 23 (a)
Species where no ortholog for CLEC18B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CLEC18B Gene

Gene Tree for CLEC18B (if available)
Gene Tree for CLEC18B (if available)

Paralogs for CLEC18B Gene

(2) SIMAP similar genes for CLEC18B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLEC18B: view

Variants for CLEC18B Gene

Sequence variations from dbSNP and Humsavar for CLEC18B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000262178 -- 74,422,771(+) GTGAT(C/T)CTTCC intron-variant, upstream-variant-2KB
rs1000314176 -- 74,423,861(+) TCCAA(C/T)GGCGT intron-variant, upstream-variant-2KB
rs1000599627 -- 74,418,693(+) TGTGA(C/T)GCAAA intron-variant
rs1000650571 -- 74,419,332(+) CTGGG(A/G)CCAGG intron-variant
rs1002323828 -- 74,421,565(+) CCCGC(A/G)GCCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLEC18B Gene

Variant ID Type Subtype PubMed ID
dgv488n67 CNV loss 20364138
dgv852e212 CNV loss 25503493
dgv853e212 CNV gain 25503493
dgv854e212 CNV loss 25503493
dgv855e212 CNV gain 25503493
esv22159 CNV gain+loss 19812545
esv2758656 CNV gain+loss 17122850
esv2760420 CNV gain+loss 21179565
esv2762054 CNV gain 21179565
esv32572 CNV gain 17666407
esv3571520 CNV gain 25503493
nsv1065964 CNV gain 25217958
nsv1076436 CNV duplication 25765185
nsv1118585 CNV duplication 24896259
nsv1124743 CNV duplication 24896259
nsv1151078 CNV duplication 26484159
nsv1160432 CNV duplication 26073780
nsv442726 CNV gain 18776908
nsv509632 CNV insertion 20534489
nsv572974 CNV loss 21841781
nsv819754 CNV loss 19587683
nsv821530 CNV duplication 20802225
nsv827736 CNV gain 20364138
nsv833277 CNV loss 17160897
nsv833278 CNV loss 17160897
nsv9457 CNV gain+loss 18304495
nsv974836 CNV duplication 23825009

Variation tolerance for CLEC18B Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC18B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC18B Gene

Disorders for CLEC18B Gene

Relevant External Links for CLEC18B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLEC18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC18B Gene

Publications for CLEC18B Gene

  1. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. (PMID: 26170455) Huang Y.L. … Hsieh S.L. (J. Biol. Chem. 2015) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. The C-type lectin-like domain superfamily. (PMID: 16336259) Zelensky A.N. … Gready J.E. (FEBS J. 2005) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for CLEC18B Gene

Sources for CLEC18B Gene

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