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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CLEC18A Gene

protein-coding GIFtS: 39
GCID: GC16P069985

C-type lectin domain family 18, member A

Explore 1 disease affiliated with
CLEC18A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 18, Member A¹ ²		MRCL1²
MRCL¹ ²		C-Type Lectin Domain Family 18 Member A²
Mannose Receptor-Like Protein 2² ³		Mannose Receptor-Like 1²
MRLP2² ³		Mannose Receptor-Like Protein 3²

External Ids:	HGNC: 30388¹	Entrez Gene: 348174²	Ensembl: ENSG00000157322⁷	UniProtKB: A5D8T8³

Export aliases for CLEC18A gene to outside databases

Previous GC identifer: GC16P068544

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLEC18A:

This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type

lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion,

immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed

for this gene. (provided by RefSeq, Sep 2012)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CLEC18A gene promoter:
Max1 GR ER-alpha Pbx1a GR-beta STAT5A Zic1 ZIC2/Zic2 GR-alpha c-Myc
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for CLEC18A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC18A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1

CLEC18A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC18A gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P069985: view genomic region (about GC identifiers)

Start:	69,984,626 bp from pter	End:	69,998,141 bp from pter
Size:	13,516 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CL18A_HUMAN, A5D8T8 (See protein sequence)

Recommended Name: C-type lectin domain family 18 member A precursor

Size: 446 amino acids; 49602 Da

Subcellular location: Secreted (Potential)

Sequence caution: Sequence=AAH08616.1; Type=Erroneous initiation;

Secondary accessions: A8K1G9 Q6DCB3 Q7Z5K9 Q96HH2

Alternative splicing: 2 isoforms: A5D8T8-1 A5D8T8-2

Explore the universe of human proteins at neXtProt for CLEC18A: NX_A5D8T8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A5D8T8

CLEC18A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001129686.1 NP_001258126.1 NP_872425.2

ENSEMBL proteins:

ENSP00000377304 ENSP00000454685 ENSP00000288040 ENSP00000454976 ENSP00000413990

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

CLEC18A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CLEC18A for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR000742 EG-like_dom

IPR014044 CAP_domain

IPR001283 Allrgn_V5/Tpx1

IPR016187 C-type_lectin_fold

IPR018378 C-type_lectin_CS

Graphical View of Domain Structure for InterPro Entry A5D8T8

ProtoNet protein and cluster: A5D8T8

UniProtKB/Swiss-Prot: CL18A_HUMAN, A5D8T8

Similarity: Contains 1 C-type lectin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 SCP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030246	carbohydrate binding	IEA	--

CLEC18A for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Clec18a^tm1Lex for CLEC18A
     1 MGI phenotypic allele

for Clec18a (no phenotypes)

CLEC18A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CLEC18A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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Search CenterWatch for drugs/clinical trials and news about CLEC18A / CL18A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CLEC18A gene (3 alternative transcripts):

NM_001136214.2 NM_001271197.1 NM_182619.3

Unigene Cluster for CLEC18A:

C-type lectin domain family 18, member A

Hs.592064 [show with all ESTs]

Unigene Representative Sequence: NM_182619

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000393701(uc002exz.3) ENST00000568461(uc010vlo.2) ENST00000568102(uc010vlp.2 uc002eya.3)

ENST00000288040 ENST00000565705 ENST00000565245 ENST00000561889 ENST00000449317

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Additional cDNA sequence:

AF428259.1 AF521893.1 AK074773.1 AK289884.1 AK298310.1 BC078143.1 BC141808.1

12 DOTS entries:

DT.408627 DT.101982772 DT.120684573 DT.95373006 DT.97858387 DT.120698532 DT.120698528 DT.100813484

DT.120684438 DT.120684650 DT.120698518 DT.99936337

16 AceView cDNA sequences:

NM_173619 AI433291 BC062573 BX280233 BC039068 AK074773 BI762690 AL833339

AI522123 BV205319 BE552150 CD673170 BI764403 BI757380 AF448856 AL040183

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLEC18A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CLEC18A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CLEC18A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLEC18A

SOURCE GeneReport for Unigene cluster: Hs.592064

SABiosciences Expression via Pathway-Focused PCR Array including CLEC18A:

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CLEC18A gene from 3/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC431137¹	C-type lectin domain family 18 member A-like	71.52(n) 67.84(a)		431137 XM_428688.3 XP_428688.3
fruit fly (Drosophila melanogaster)	Insecta	CG8483⁶	--	15(a)	1 → many	3R(9034470-9040187)
worm (Caenorhabditis elegans)	Secernentea	lon-1⁶	Protein lon-1	18(a)	1 → many	III(5474437-5478343)

ENSEMBL Gene Tree for CLEC18A (if available)
TreeFam Gene Tree for CLEC18A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CLEC18A gene

CLEC18C¹ ² CLEC18B¹ ² CRISPLD2² PI16² GLIPR1² CRISP2² PI15² CRISP1²

CRISPLD1² CRISP3² GLIPR1L1² GLIPR1L2² R3HDML²

4 SIMAP similar genes for CLEC18A using alignment to 3 protein entries: CL18A_HUMAN (see all proteins):

CLEC18B CLEC18C CRISPLD2 DKFZp686H17246

CLEC18A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145925820^1,2		--	69983724(+)	`AAAATA/GATAAT`	3	--	us2k¹		0	--	--	--	--
rs199888154^1,2		--	69983872(+)	`GTCTA-/AAAAAT AAAAA`	3	--	us2k¹		0	--	--	--	--
rs139813358^1,2		--	69984145(+)	`ACAGAC/GTTGGA`	3	--	us2k¹		0	--	--	--	--
rs2650535^1,2	C	--	69984299(+)	`AGCCCG/ACAGGA`	3	--	us2k¹		1		NA	2
rs200598028^1,2	F	--	69985248(+)	`GGAGCG/ACCTGA`	3	--	ut5¹		1		EU	991
rs201077214^1,2	F	--	69985255(+)	`CTGACG/AGGCCC`	3	--	ut5¹		1		EU	1205
rs199537784^1,2	F	--	69985274(+)	`CATGCT/CGCATC`	6	/P /L	mis¹		1		EU	1185
rs201275802^1,2	C,F	--	69985339(+)	`GCACCG/ACCTGG`	6	/T /A	mis¹		1		EU	623
rs201892990^1,2	F	--	69985340(+)	`CACCGC/TCTGGG`	6	A V	mis¹		1		EU	1311
rs145506602^1,2		--	69986566(+)	`ATAGAA/GTTCCC`	3	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CLEC18A (69984626 - 69998141 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for CLEC18A
13 CNVs: 77392 88186 77389 77390 77393 88187 32128 88184 4009 72603 88183 72604 72601
1 Indel: 40148

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CLEC18A for disorders About GeneDecksing

1 disease for CLEC18A: About MalaCards

liposarcoma

1 disease from the University of Copenhagen DISEASES database for CLEC18A:

Liposarcoma

Export disorders for CLEC18A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CLEC18A gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLEC18A)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 3} Clark H.F.... Gray A.M. (2003)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
The C-type lectin-like domain superfamily. (PubMed id 16336259)¹ Zelensky A.N. and Gready J.E. (2005)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)¹ Otsuki T....Isogai T. (2005)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)² Martin J.... Pennacchio L.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 348174	HGNC: 30388	AceView: MGC34761	Ensembl:ENSG00000157322	euGenes: HUgn348174
ECgene: CLEC18A	H-InvDB: CLEC18A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CLEC18A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CLEC18A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CLEC18A gene:
Search GeneIP for patents involving CLEC18A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLEC18A
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	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC18A
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	GenScript Custom Purified and Recombinant Proteins Services for CLEC18A		GenScript cDNA clones with any tag delivered in your preferred vector for CLEC18A
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	GenScript Custom overexpressing Cell Line Services for CLEC18A		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC18A

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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CLEC18A Gene

C-type lectin domain family 18, member A

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CLEC18A Gene

C-type lectin domain family 18, member A

Aliasesfor CLEC18A gene

Summariesfor CLEC18A gene

Genomic Viewsfor CLEC18A gene

Proteinsfor CLEC18A gene

Protein Domains /Familiesfor CLEC18A gene

Functionfor CLEC18A gene

Pathways & Interactionsfor CLEC18A gene

Drugs & Compoundsfor CLEC18A gene

Transcriptsfor CLEC18A gene

Expression for CLEC18A gene

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Disorders / Diseasesfor CLEC18A gene

Publicationsfor CLEC18A gene

External Searches for CLEC18A gene

Genome Databases showing CLEC18A gene

Other Databases showing CLEC18A gene

Specialized Databases showing CLEC18A gene

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Aliases
for CLEC18A gene

Summaries
for CLEC18A gene

Genomic Views
for CLEC18A gene

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for CLEC18A gene

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Families
for CLEC18A gene

Function
for CLEC18A gene

Pathways & Interactions
for CLEC18A gene

Drugs & Compounds
for CLEC18A gene

Transcripts
for CLEC18A gene

Expression
for CLEC18A gene

Orthologs
for CLEC18A gene

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for CLEC18A gene

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for CLEC18A gene

Disorders / Diseases
for CLEC18A gene

Publications
for CLEC18A gene

Intellectual Property
for CLEC18A gene

Products
for CLEC18A gene