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Aliases for CLEC18A Gene

Aliases for CLEC18A Gene

  • C-Type Lectin Domain Family 18 Member A 2 3 5
  • C-Type Lectin Domain Family 18, Member A 2 3
  • Mannose Receptor-Like Protein 2 3 4
  • MRLP2 3 4
  • Mannose Receptor-Like Protein 3 3
  • Mannose Receptor-Like 1 3
  • Mannose Receptor-Like 2
  • MRCL1 3
  • MRCL 3

External Ids for CLEC18A Gene

Previous GeneCards Identifiers for CLEC18A Gene

  • GC16P068544
  • GC16P069985

Summaries for CLEC18A Gene

Entrez Gene Summary for CLEC18A Gene

  • This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]

GeneCards Summary for CLEC18A Gene

CLEC18A (C-Type Lectin Domain Family 18 Member A) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot for CLEC18A Gene

  • Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans (PubMed:26170455).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC18A Gene

Genomics for CLEC18A Gene

Regulatory Elements for CLEC18A Gene

Enhancers for CLEC18A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLEC18A on UCSC Golden Path with GeneCards custom track

Promoters for CLEC18A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLEC18A on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC18A Gene

Chromosome:
16
Start:
69,950,394 bp from pter
End:
69,964,452 bp from pter
Size:
14,059 bases
Orientation:
Plus strand

Genomic View for CLEC18A Gene

Genes around CLEC18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC18A Gene

Proteins for CLEC18A Gene

  • Protein details for CLEC18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5D8T8-CL18A_HUMAN
    Recommended name:
    C-type lectin domain family 18 member A
    Protein Accession:
    A5D8T8
    Secondary Accessions:
    • A8K1G9
    • Q6DCB3
    • Q7Z5K9
    • Q96HH2

    Protein attributes for CLEC18A Gene

    Size:
    446 amino acids
    Molecular mass:
    49602 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08616.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CLEC18A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC18A Gene

Proteomics data for CLEC18A Gene at MOPED

Post-translational modifications for CLEC18A Gene

No data available for DME Specific Peptides for CLEC18A Gene

Domains & Families for CLEC18A Gene

Gene Families for CLEC18A Gene

Suggested Antigen Peptide Sequences for CLEC18A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A5D8T8

UniProtKB/Swiss-Prot:

CL18A_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 SCP domain.
genes like me logo Genes that share domains with CLEC18A: view

Function for CLEC18A Gene

Molecular function for CLEC18A Gene

UniProtKB/Swiss-Prot Function:
Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans (PubMed:26170455).

Gene Ontology (GO) - Molecular Function for CLEC18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CLEC18A: view

Phenotypes for CLEC18A Gene

GenomeRNAi human phenotypes for CLEC18A:
genes like me logo Genes that share phenotypes with CLEC18A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC18A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC18A Gene

Localization for CLEC18A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC18A Gene

Secreted. Endoplasmic reticulum. Golgi apparatus. Endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC18A Gene COMPARTMENTS Subcellular localization image for CLEC18A gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
extracellular 5
golgi apparatus 5
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLEC18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS 26170455
GO:0005783 endoplasmic reticulum TAS 26170455
genes like me logo Genes that share ontologies with CLEC18A: view

Pathways & Interactions for CLEC18A Gene

SuperPathways for CLEC18A Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLEC18A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLEC18A Gene

Drugs & Compounds for CLEC18A Gene

No Compound Related Data Available

Transcripts for CLEC18A Gene

Unigene Clusters for CLEC18A Gene

C-type lectin domain family 18, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC18A Gene

No ASD Table

Relevant External Links for CLEC18A Gene

GeneLoc Exon Structure for
CLEC18A
ECgene alternative splicing isoforms for
CLEC18A

Expression for CLEC18A Gene

mRNA expression in normal human tissues for CLEC18A Gene

mRNA differential expression in normal tissues according to GTEx for CLEC18A Gene

This gene is overexpressed in Kidney - Cortex (x17.7) and Artery - Aorta (x6.5).

SOURCE GeneReport for Unigene cluster for CLEC18A Gene Hs.592064

mRNA Expression by UniProt/SwissProt for CLEC18A Gene

A5D8T8-CL18A_HUMAN
Tissue specificity: Dectected in all cell lines tested and in peripheral blood cells.
genes like me logo Genes that share expression patterns with CLEC18A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CLEC18A Gene

Orthologs for CLEC18A Gene

This gene was present in the common ancestor of animals.

Orthologs for CLEC18A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRCL 36
  • 46 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Clec18a 36
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CLEC18A 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lon-1 36
  • 23 (a)
OneToMany
Species with no ortholog for CLEC18A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CLEC18A Gene

ENSEMBL:
Gene Tree for CLEC18A (if available)
TreeFam:
Gene Tree for CLEC18A (if available)

Paralogs for CLEC18A Gene

(3) SIMAP similar genes for CLEC18A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLEC18A: view

Variants for CLEC18A Gene

Sequence variations from dbSNP and Humsavar for CLEC18A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2549097 - 69,954,470(+) CTTGG(C/T)GTCCT intron-variant, nc-transcript-variant, reference, missense
VAR_074610 -
VAR_074611 -
rs3869413 -- 69,962,141(+) CTGGT(A/G)GAGCC intron-variant, downstream-variant-500B
rs3869427 -- 69,954,416(+) CGGCC(C/T)GTGGC intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CLEC18A Gene

Variant ID Type Subtype PubMed ID
dgv895e1 CNV Complex 17122850
nsv509630 CNV Insertion 20534489
nsv1853 CNV Loss 18451855
esv25670 CNV Gain+Loss 19812545
nsv9452 CNV Loss 18304495
dgv2892n71 CNV Gain 21882294
dgv2893n71 CNV Gain 21882294
dgv485n67 CNV Loss 20364138
esv2714669 CNV Deletion 23290073
nsv428328 CNV Gain+Loss 18775914
dgv2894n71 CNV Gain 21882294
dgv2895n71 CNV Loss 21882294

Variation tolerance for CLEC18A Gene

Gene Damage Index Score: 11.26; 92.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC18A Gene

HapMap Linkage Disequilibrium report
CLEC18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC18A Gene

Disorders for CLEC18A Gene

Relevant External Links for CLEC18A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC18A

No disorders were found for CLEC18A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC18A Gene

Publications for CLEC18A Gene

  1. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. (PMID: 26170455) Huang Y.L. … Hsieh S.L. (J. Biol. Chem. 2015) 3 4 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for CLEC18A Gene

Sources for CLEC18A Gene

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