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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC17A Gene

protein-coding   GIFtS: 39
GCID: GC19P014693

C-type lectin domain family 17, member A
 Explore 1 disease affiliated with
CLEC17A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLEC17A    

Aliases
for CLEC17A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
C-Type Lectin Domain Family 17, Member A1 2
FLJ459101
Prolectin3
Prolectin3

External Ids:    HGNC: 345201   Entrez Gene: 3885122   Ensembl: ENSG000001879127   UniProtKB: Q6ZS103   

Export aliases for CLEC17A gene to outside databases

Previous GC identifers: GC19P014559 GC19P014565 GC19P014264


Summaries
for CLEC17A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CL17A_HUMAN, Q6ZS10
Function: Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the
germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues




Genomic Views
for CLEC17A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC17A gene promoter:
         ER-alpha   RFX1   AML1a   Pbx1a   STAT5A   NF-kappaB   PPAR-gamma1   PPAR-gamma2   ZID   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLEC17A promoter sequence
   Search SABiosciences Chromatin IP Primers for CLEC17A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC17A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

CLEC17A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC17A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P014693:  view genomic region     (about GC identifiers)

Start:
 14,693,896 bp from pter      End:
 14,721,969 bp from pter
Size:
 28,074 bases      Orientation:
 plus strand

Proteins
for CLEC17A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CL17A_HUMAN, Q6ZS10 (See protein sequence)
Recommended Name: C-type lectin domain family 17, member A  
Size: 378 amino acids; 42935 Da
Subunit: Oligomer; disulfide-linked
Subcellular location: Membrane; Single-pass type II membrane protein (Potential). Note=In fibroblasts, expressed on the
cell surface
Sequence caution: Sequence=EAW84437.1; Type=Erroneous gene model prediction;
Secondary accessions: A8MX68 B2RTX0 B7ZMM4
Alternative splicing: 3 isoforms:  Q6ZS10-1   Q6ZS10-2   Q6ZS10-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CLEC17A: NX_Q6ZS10

Post-translational modifications:

  • Phosphorylated on tyrosine residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZS10

    • CLEC17A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001191047.1  NP_997273.3  

    ENSEMBL proteins: 
     ENSP00000450065   ENSP00000393719   ENSP00000341620   ENSP00000447424   ENSP00000380581  

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    Uscn Proteins for CLEC17A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009986cell surface IDA19419970
    GO:0016021integral to membrane IEA--


    CLEC17A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CLEC17A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLEC17A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q6ZS10

    ProtoNet protein and cluster: Q6ZS10

    UniProtKB/Swiss-Prot: CL17A_HUMAN, Q6ZS10
    Similarity: Contains 1 C-type lectin domain


    Function
    for CLEC17A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CL17A_HUMAN, Q6ZS10
    Function: Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the
    germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues

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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005537mannose binding IDA19419970
    GO:0042806fucose binding IDA19419970
    GO:0046872metal ion binding IEA--


    CLEC17A for ontologies           About GeneDecksing



    Pathways & Interactions
    for CLEC17A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC17A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CLEC17A (ENSP000003805814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BLNKENSP000002243374STRING: ENSP00000224337
    About this table

    Drugs & Compounds
    for CLEC17A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLEC17A
    Search CenterWatch for drugs/clinical trials and news about CLEC17A / CL17A 

    Transcripts
    for CLEC17A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLEC17A gene (2 alternative transcripts): 
    NM_001204118.1  NM_207390.3  

    Unigene Cluster for CLEC17A:

    C-type lectin domain family 17, member A
    Hs.567933  [show with all ESTs]
    Unigene Representative Sequence: NM_001204118
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000547437(uc010dzn.2 uc010dzo.2 uc010xnt.2 uc010xnu.2)
    ENST00000417570 ENST00000339847 ENST00000551730 ENST00000397439(uc002mzh.2)


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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    BC140848.1 BC144664.1 BC144665.1 

    3 DOTS entries:

    DT.121441928  DT.65286047  DT.101973515 

    6 AceView cDNA sequences:

    AI762955 AK127809 NM_207390 BE672128 AW204171 AW205281 

    GeneLoc Exon Structure


    Expression
    for CLEC17A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLEC17A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGTCCCCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CLEC17A Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.567933

    UniProtKB/Swiss-Prot: CL17A_HUMAN, Q6ZS10
    Tissue specificity: Expressed on dividing B-cells of germinal centers in various tissues, including lymph nodes,
    tonsils, stomach, intestine, appendix and spleen

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC17A

    Orthologs
    for CLEC17A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC17A gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC4261061 C-type lectin domain family 17, member A-like 48.26(n)
    35.65(a)    		   426106  XM_423779.3  XP_423779.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-170d8.56
    si:ch211-170d8.86
    		 si:ch211-170d8.8
    		 20(a)
    18(a)
    		 possible ortholog
    possible ortholog
    		 8(41685924-41692286)
    8(41695385-41707267)
            Species with no ortholog for CLEC17A

    ENSEMBL Gene Tree for CLEC17A (if available)
    TreeFam Gene Tree for CLEC17A (if available) 

    Paralogs
    for CLEC17A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CLEC17A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/593 NCBI SNPs in CLEC17A are shown (see all 593)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs730028681,2
    		--14691976(+) TTGTTA/GTTGAA 2 -- us2k10--------
    rs1817592441,2
    		--14691986(+) AGCCAA/GTCTGA 2 -- us2k10--------
    rs1841453711,2
    		--14692284(+) GTGCCC/TGCTAT 2 -- us2k10--------
    rs1177333301,2
    		--14692449(+) AGAAAT/CGGATT 2 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1422682081,2
    		--14692533(+) GATCTC/TGGCTC 2 -- us2k10--------
    rs1887172861,2
    		--14692534(+) ATCTCG/TGCTCA 2 -- us2k10--------
    rs72564141,2
    		C,A,--14692699(+) CCTCAG/CGTGAT 2 -- us2k1 tfbs31Minor allele frequency- C:0.00CSA 1
    rs1428133081,2
    		C,--14692778(+) TATAG-/TTCTGG 2 -- us2k10--------
    rs556533431,2
    		F,--14692783(+) TTCTGG/CAGTCA 2 -- us2k11Minor allele frequency- C:0.04NA 120
    rs72555071,2
    		C,F,H,--14692790(+) GTCAGG/AAGACC 2 -- us2k121Minor allele frequency- A:0.09NS EA NA CSA WA 2474

    HapMap Linkage Disequilibrium report for CLEC17A (14693896 - 14721969 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for CLEC17A
         8 CNVs: 89118 89116 78105 89119 59641 89117 78104 67477
         2 Indels: 61674 102790

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    Disorders / Diseases
    for CLEC17A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLEC17A for disorders           About GeneDecksing

    1 disease for CLEC17A:    About MalaCards
    tonsillitis


    Export disorders for CLEC17A gene to outside databases

    Publications
    for CLEC17A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLEC17A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CLEC17A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prolectin, a glycan-binding receptor on dividing B ce lls in germinal centers. (PubMed id 19419970)1, 2, 3 Graham S.A....Drickamer K. (2009)
    2. The B-cell antigen receptor signals through a preform ed transducer module of SLP65 and CIN85. (PubMed id 21822214)1 Oellerich T....Wienands J. (2011)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for CLEC17A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CLEC17A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388512 HGNC: 34520 AceView: FLJ45910 Ensembl:ENSG00000187912 euGenes: HUgn388512
    ECgene: CLEC17A H-InvDB: CLEC17A

    Other Databases showing CLEC17A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLEC17A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLEC17A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLEC17A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLEC17A gene:
    Search GeneIP for patents involving CLEC17A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CLEC17A gene

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    Advanced Cell Diagnostics
    About This Section

     
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