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Aliases for CLEC17A Gene

Aliases for CLEC17A Gene

  • C-Type Lectin Domain Family 17 Member A 2 3 5
  • Prolectin 2 3 4
  • C-Type Lectin Domain Family 17, Member A 2

External Ids for CLEC17A Gene

Previous GeneCards Identifiers for CLEC17A Gene

  • GC19P014559
  • GC19P014693
  • GC19P014264

Summaries for CLEC17A Gene

GeneCards Summary for CLEC17A Gene

CLEC17A (C-Type Lectin Domain Family 17 Member A) is a Protein Coding gene. GO annotations related to this gene include mannose binding and fucose binding. An important paralog of this gene is CLEC6A.

UniProtKB/Swiss-Prot for CLEC17A Gene

  • Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC17A Gene

Genomics for CLEC17A Gene

Regulatory Elements for CLEC17A Gene

Promoters for CLEC17A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLEC17A on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC17A Gene

Chromosome:
19
Start:
14,582,914 bp from pter
End:
14,611,157 bp from pter
Size:
28,244 bases
Orientation:
Plus strand

Genomic View for CLEC17A Gene

Genes around CLEC17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC17A Gene

Proteins for CLEC17A Gene

  • Protein details for CLEC17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS10-CL17A_HUMAN
    Recommended name:
    C-type lectin domain family 17, member A
    Protein Accession:
    Q6ZS10
    Secondary Accessions:
    • A8MX68
    • B2RTX0
    • B7ZMM4

    Protein attributes for CLEC17A Gene

    Size:
    378 amino acids
    Molecular mass:
    42935 Da
    Quaternary structure:
    • Oligomer; disulfide-linked.
    SequenceCaution:
    • Sequence=EAW84437.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CLEC17A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC17A Gene

Proteomics data for CLEC17A Gene at MOPED

Post-translational modifications for CLEC17A Gene

Other Protein References for CLEC17A Gene

No data available for DME Specific Peptides for CLEC17A Gene

Domains & Families for CLEC17A Gene

Gene Families for CLEC17A Gene

Protein Domains for CLEC17A Gene

Suggested Antigen Peptide Sequences for CLEC17A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZS10

UniProtKB/Swiss-Prot:

CL17A_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC17A: view

Function for CLEC17A Gene

Molecular function for CLEC17A Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues.

Gene Ontology (GO) - Molecular Function for CLEC17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005537 mannose binding IDA 19419970
genes like me logo Genes that share ontologies with CLEC17A: view

Phenotypes for CLEC17A Gene

genes like me logo Genes that share phenotypes with CLEC17A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC17A Gene

Localization for CLEC17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC17A Gene

Membrane; Single-pass type II membrane protein. Note=In fibroblasts, expressed on the cell surface. {ECO:0000269 PubMed:19419970}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC17A Gene COMPARTMENTS Subcellular localization image for CLEC17A gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CLEC17A Gene

Pathways & Interactions for CLEC17A Gene

SuperPathways for CLEC17A Gene

No Data Available

Interacting Proteins for CLEC17A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000393719%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000393719 for CLEC17A Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for CLEC17A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLEC17A Gene

Drugs & Compounds for CLEC17A Gene

No Compound Related Data Available

Transcripts for CLEC17A Gene

mRNA/cDNA for CLEC17A Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC17A Gene

C-type lectin domain family 17, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC17A Gene

No ASD Table

Relevant External Links for CLEC17A Gene

GeneLoc Exon Structure for
CLEC17A
ECgene alternative splicing isoforms for
CLEC17A

Expression for CLEC17A Gene

mRNA expression in normal human tissues for CLEC17A Gene

mRNA differential expression in normal tissues according to GTEx for CLEC17A Gene

This gene is overexpressed in Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for CLEC17A Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC17A Gene



SOURCE GeneReport for Unigene cluster for CLEC17A Gene Hs.567933

mRNA Expression by UniProt/SwissProt for CLEC17A Gene

Q6ZS10-CL17A_HUMAN
Tissue specificity: Expressed on dividing B-cells of germinal centers in various tissues, including lymph nodes, tonsils, stomach, intestine, appendix and spleen.
genes like me logo Genes that share expression patterns with CLEC17A: view

Protein tissue co-expression partners for CLEC17A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CLEC17A Gene

Orthologs for CLEC17A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC17A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CLEC17A 35
  • 84.58 (n)
  • 76.87 (a)
CLEC17A 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLEC17A 35
  • 99.27 (n)
  • 98.69 (a)
CLEC17A 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 22 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC426106 35
  • 48.68 (n)
  • 35.81 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
ManyToMany
Species with no ortholog for CLEC17A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC17A Gene

ENSEMBL:
Gene Tree for CLEC17A (if available)
TreeFam:
Gene Tree for CLEC17A (if available)

Paralogs for CLEC17A Gene

(6) SIMAP similar genes for CLEC17A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLEC17A: view

Variants for CLEC17A Gene

Sequence variations from dbSNP and Humsavar for CLEC17A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1816268 -- 14,589,344(-) AAAGG(A/G)GAAGG intron-variant
rs1816269 -- 14,589,266(-) AGGTG(A/G)GGTTT intron-variant
rs2016008 -- 14,584,083(-) CTCTA(C/T)TTTTT intron-variant
rs2396225 -- 14,590,281(-) TGTAG(A/C)GAGGT intron-variant
rs2396226 -- 14,586,189(-) aagat(C/T)gcacc intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLEC17A Gene

Variant ID Type Subtype PubMed ID
esv25063 CNV Loss 19812545
esv2718215 CNV Deletion 23290073
esv7099 CNV Loss 19470904
esv2650508 CNV Insertion 19546169
nsv820025 CNV Insertion 19587683
esv2718216 CNV Deletion 23290073

Variation tolerance for CLEC17A Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.49; 77.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC17A Gene

HapMap Linkage Disequilibrium report
CLEC17A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC17A Gene

Disorders for CLEC17A Gene

Relevant External Links for CLEC17A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC17A

No disorders were found for CLEC17A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC17A Gene

Publications for CLEC17A Gene

  1. Prolectin, a glycan-binding receptor on dividing B cells in germinal centers. (PMID: 19419970) Graham S.A. … Drickamer K. (J. Biol. Chem. 2009) 2 3 4 67
  2. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PMID: 23453885) (Lancet 2013) 3
  3. The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85. (PMID: 21822214) Oellerich T. … Wienands J. (EMBO J. 2011) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CLEC17A Gene

Sources for CLEC17A Gene

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