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Aliases for CLEC17A Gene

Aliases for CLEC17A Gene

  • C-Type Lectin Domain Family 17, Member A 2 3
  • Prolectin 2 3 4

External Ids for CLEC17A Gene

Summaries for CLEC17A Gene

GeneCards Summary for CLEC17A Gene

CLEC17A (C-Type Lectin Domain Family 17, Member A) is a Protein Coding gene. GO annotations related to this gene include mannose binding and fucose binding. An important paralog of this gene is CLEC4D.

UniProtKB/Swiss-Prot for CLEC17A Gene

  • Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC17A Gene

Genomics for CLEC17A Gene

Genomic Location for CLEC17A Gene

Start:
14,583,084 bp from pter
End:
14,611,157 bp from pter
Size:
28,074 bases
Orientation:
Plus strand

Genomic View for CLEC17A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC17A Gene

Regulatory Elements for CLEC17A Gene

Proteins for CLEC17A Gene

  • Protein details for CLEC17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS10-CL17A_HUMAN
    Recommended name:
    C-type lectin domain family 17, member A
    Protein Accession:
    Q6ZS10
    Secondary Accessions:
    • A8MX68
    • B2RTX0
    • B7ZMM4

    Protein attributes for CLEC17A Gene

    Size:
    378 amino acids
    Molecular mass:
    42935 Da
    Quaternary structure:
    • Oligomer; disulfide-linked.
    SequenceCaution:
    • Sequence=EAW84437.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CLEC17A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC17A Gene

Proteomics data for CLEC17A Gene at MOPED

Post-translational modifications for CLEC17A Gene

Other Protein References for CLEC17A Gene

No data available for DME Specific Peptides for CLEC17A Gene

Domains for CLEC17A Gene

Gene Families for CLEC17A Gene

HGNC:
  • CLEC :C-type lectin domain containing

Protein Domains for CLEC17A Gene

UniProtKB/Swiss-Prot:

CL17A_HUMAN
Domain:
  • Contains 1 C-type lectin domain.:
    • Q6ZS10
genes like me logo Genes that share domains with CLEC17A: view

Function for CLEC17A Gene

Molecular function for CLEC17A Gene

UniProtKB/Swiss-Prot Function: Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues.

Gene Ontology (GO) - Molecular Function for CLEC17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005537 mannose binding IDA 19419970
GO:0042806 fucose binding IDA 19419970
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CLEC17A: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLEC17A Gene

Localization for CLEC17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC17A Gene

Membrane; Single-pass type II membrane protein. Note=In fibroblasts, expressed on the cell surface. {ECO:0000269 PubMed:19419970}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC17A Gene COMPARTMENTS Subcellular localization image for CLEC17A gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
golgi apparatus 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CLEC17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IDA 19419970
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC17A: view

Pathways for CLEC17A Gene

SuperPathways for CLEC17A Gene

No Data Available

Interacting Proteins for CLEC17A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000393719%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000393719 for CLEC17A Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for CLEC17A Gene

None

No data available for Pathways by source for CLEC17A Gene

Transcripts for CLEC17A Gene

mRNA/cDNA for CLEC17A Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC17A Gene

C-type lectin domain family 17, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC17A Gene

No ASD Table

Relevant External Links for CLEC17A Gene

GeneLoc Exon Structure for
CLEC17A
ECgene alternative splicing isoforms for
CLEC17A

Expression for CLEC17A Gene

mRNA expression in normal human tissues for CLEC17A Gene

mRNA differential expression in normal tissues according to GTEx for CLEC17A Gene

This gene is overexpressed in Spleen (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLEC17A Gene

SOURCE GeneReport for Unigene cluster for CLEC17A Gene Hs.567933

mRNA Expression by UniProt/SwissProt for CLEC17A Gene

Q6ZS10-CL17A_HUMAN
Tissue specificity: Expressed on dividing B-cells of germinal centers in various tissues, including lymph nodes, tonsils, stomach, intestine, appendix and spleen.
genes like me logo Genes that share expressions with CLEC17A: view

Orthologs for CLEC17A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC17A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC17A 36
  • 99.27 (n)
  • 98.69 (a)
CLEC17A 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC17A 36
  • 84.58 (n)
  • 76.87 (a)
CLEC17A 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 22 (a)
ManyToMany
-- 37
  • 19 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 42 (a)
OneToMany
-- 37
  • 38 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC426106 36
  • 48.68 (n)
  • 35.81 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 36 (a)
ManyToMany
Species with no ortholog for CLEC17A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC17A Gene

ENSEMBL:
Gene Tree for CLEC17A (if available)
TreeFam:
Gene Tree for CLEC17A (if available)

Paralogs for CLEC17A Gene

Selected SIMAP similar genes for CLEC17A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLEC17A: view

Variants for CLEC17A Gene

Sequence variations from dbSNP and Humsavar for CLEC17A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1816269 -- 14,589,266(-) AGGTG(A/G)GGTTT intron-variant
rs2016008 -- 14,584,083(-) CTCTA(C/T)TTTTT intron-variant
rs2396225 -- 14,590,281(-) TGTAG(A/C)GAGGT intron-variant
rs2396226 -- 14,586,189(-) aagat(C/T)gcacc intron-variant
rs2396227 -- 14,584,202(-) gcaga(C/T)gcccg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC17A Gene

Variant ID Type Subtype PubMed ID
esv25063 CNV Loss 19812545
esv2718215 CNV Deletion 23290073
esv7099 CNV Loss 19470904
esv2650508 CNV Insertion 19546169
nsv820025 CNV Insertion 19587683
esv2718216 CNV Deletion 23290073

Relevant External Links for CLEC17A Gene

HapMap Linkage Disequilibrium report
CLEC17A

Disorders for CLEC17A Gene

No disorders were found for CLEC17A Gene.

No data available for UniProtKB/Swiss-Prot for CLEC17A Gene

Publications for CLEC17A Gene

  1. Prolectin, a glycan-binding receptor on dividing B cells in germinal centers. (PMID: 19419970) Graham S.A. … Drickamer K. (J. Biol. Chem. 2009) 2 3 4
  2. The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85. (PMID: 21822214) Oellerich T. … Wienands J. (EMBO J. 2011) 3
  3. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PMID: 23453885) (Lancet 2013) 3
  4. Proteomic analysis reveals a FANCA-modulated neddylation pathway involved in CXCR5 membrane targeting and cell mobility. (PMID: 25015289) Renaudin X. … Rosselli F. (J. Cell. Sci. 2014) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for CLEC17A Gene

Sources for CLEC17A Gene

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