Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC16A Gene

protein-coding   GIFtS: 51
GCID: GC16P011038

C-Type Lectin Domain Family 16, Member A

(Previous name: KIAA0350)
(Previous symbol: KIAA0350)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 16, Member A1 2
KIAA03501 2 3 5
Gop-12
Protein CLEC16A2

External Ids:    HGNC: 290131   Entrez Gene: 232742   Ensembl: ENSG000000385327   OMIM: 6113035   UniProtKB: Q2KHT33   

Export aliases for CLEC16A gene to outside databases

Previous GC identifers: GC16P010945 GC16P010955


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLEC16A Gene:
This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in
introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug
2011)

GeneCards Summary for CLEC16A Gene: 
CLEC16A (C-type lectin domain family 16, member A) is a protein-coding gene. Diseases associated with CLEC16A include interleukin-7 receptor alpha deficiency, and multiple sclerosis.

Gene Wiki entry for CLEC16A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC16A gene promoter:
         Pax-5   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Egr-4   AREB6   POU2F1   Ik-2   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC16A promoter sequence
   Search SABiosciences Chromatin IP Primers for CLEC16A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC16A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.13   Ensembl cytogenetic band:  16p13.13   HGNC cytogenetic band: 16p13.13

CLEC16A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC16A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P011038:  view genomic region     (about GC identifiers)

Start:
11,038,345 bp from pter      End:
11,276,046 bp from pter
Size:
237,702 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CL16A_HUMAN, Q2KHT3 (See protein sequence)
Recommended Name: Protein CLEC16A  
Size: 1053 amino acids; 117715 Da
Sequence caution: Sequence=BAA20807.3; Type=Erroneous initiation;
Secondary accessions: O15058 Q6ZTB2
Alternative splicing: 3 isoforms:  Q2KHT3-1   Q2KHT3-2   Q2KHT3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLEC16A: NX_Q2KHT3

Explore proteomics data for CLEC16A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q2KHT3

  • CLEC16A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLEC16A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001230332.1  NP_056041.1  

    ENSEMBL proteins: 
     ENSP00000387122   ENSP00000386495   ENSP00000389743   ENSP00000389963   ENSP00000261657  
     ENSP00000371244  

    Human Recombinant Protein Products for CLEC16A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CLEC16A
    GenScript Custom Purified and Recombinant Proteins Services for CLEC16A
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLEC16A 


    CLEC16A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CLEC16A
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CLEC16A
    OriGene Custom Antibody Services for CLEC16A
    GenScript Custom Superior Antibodies Services for CLEC16A
    Novus Biologicals CLEC16A Antibodies
    Abcam antibodies for CLEC16A
    Cloud-Clone Corp. Antibodies for CLEC16A 
    ThermoFisher Antibodies for CLEC16A
    LSBio Antibodies in human, mouse, rat for CLEC16A 

    Assay Products for CLEC16A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CLEC16A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLEC16A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLEC16A 
    Cloud-Clone Corp. CLIAs for CLEC16A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLEC: C-type lectin domain containing

    1 InterPro protein domain:
     IPR019155 Uncharacterised_FPL

    Graphical View of Domain Structure for InterPro Entry Q2KHT3

    ProtoNet protein and cluster: Q2KHT3

    UniProtKB/Swiss-Prot: CL16A_HUMAN, Q2KHT3
    Similarity: Belongs to the CLEC16A/gop-1 family


    CLEC16A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for CLEC16A:
     Cell division defect  Increased 8N DNA content 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Clec16a):
     growth/size  hearing/vestibular/ear  limbs/digits/tail  mortality/aging  vision/eye 

    CLEC16A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLEC16A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLEC16A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC16A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLEC16A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC16A
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CLEC16A (see all 31):
    hsa-miR-579 hsa-miR-3678-3p hsa-miR-596 hsa-miR-125a-5p hsa-miR-4328 hsa-miR-137 hsa-miR-4251 hsa-miR-15a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLEC16A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC16A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLEC16A
    Sirion Biotech Customized adenovirus for overexpression of CLEC16A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CLEC16A (see all 5)
    OriGene ORF clones in mouse, rat for CLEC16A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLEC16A (NM_015226)
    Sino Biological Human cDNA Clone for CLEC16A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC16A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC16A
    Sirion Biotech Customized lentivirus for stable overexpression of CLEC16A 
                         Customized lentivirus expression plasmids for stable overexpression of CLEC16A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CLEC16A
    Search LifeMap BioReagents cell lines for CLEC16A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC16A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC16A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CLEC16A (ENSP000003871224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLEC16A (CL16A)

    Search CenterWatch for drugs/clinical trials and news about CLEC16A / CL16A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLEC16A gene (2 alternative transcripts): 
    NM_001243403.1  NM_015226.2  

    Unigene Cluster for CLEC16A:

    C-type lectin domain family 16, member A
    Hs.35490  [show with all ESTs]
    Unigene Representative Sequence: NM_015226
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409790(uc002dao.3 uc021tcy.1) ENST00000409552(uc002dan.4)
    ENST00000494853 ENST00000463896 ENST00000476025 ENST00000465491 ENST00000487189
    ENST00000463459 ENST00000428742 ENST00000436973 ENST00000261657(uc002dap.3)
    ENST00000459723 ENST00000381822
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC16A
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CLEC16A (see all 31):
    hsa-miR-579 hsa-miR-3678-3p hsa-miR-596 hsa-miR-125a-5p hsa-miR-4328 hsa-miR-137 hsa-miR-4251 hsa-miR-15a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLEC16A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC16A
    Clone
    Products:
         
    OriGene clones in human, mouse for CLEC16A (see all 5)
    OriGene ORF clones in mouse, rat for CLEC16A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLEC16A (NM_015226)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC16A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC16A
    Sirion Biotech Customized lentivirus for stable overexpression of CLEC16A 
                         Customized lentivirus expression plasmids for stable overexpression of CLEC16A 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC16A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC16A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC16A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC16A

    Additional mRNA sequence: 

    AB002348.3 AK125825.1 AK126771.1 AK128253.1 BC009721.1 BC112897.1 CR749380.1 

    14 DOTS entries:

    DT.100834490  DT.91671460  DT.442931  DT.101976048  DT.103768  DT.86840464  DT.115861  DT.95246823 
    DT.120680828  DT.426356  DT.92431589  DT.92431590  DT.92443532  DT.120680893 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC16A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c ^
    SP1:                                -                                         -                 -                                                               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27a · 27b
    SP1:  -           -               
    SP2:                              
    SP3:  -                           
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CLEC16A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLEC16A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCGTGGGT
    CLEC16A Expression
    About this image


    See CLEC16A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLEC16A

    SOURCE GeneReport for Unigene cluster: Hs.35490

    UniProtKB/Swiss-Prot: CL16A_HUMAN, Q2KHT3
    Tissue specificity: Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and
    natural killer cells

        SABiosciences Custom PCR Arrays for CLEC16A
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC16A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC16A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC16A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC16A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC16A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CLEC16A gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec16a1 , 5 C-type lectin domain family 16, member A1, 5 87.18(n)1
    91.57(a)1
      16 (5.68 cM)5
    743741  NM_177562.51  NP_808230.21 
     105453645 
    chicken
    (Gallus gallus)
    Aves CLEC16A1 C-type lectin domain family 16, member A 75.25(n)
    85.05(a)
      416632  XM_414931.3  XP_414931.3 
    lizard
    (Anolis carolinensis)
    Reptilia CLEC16A6
    C-type lectin domain family 16, member A
    79(a)
    1 ↔ 1
    GL343592.1(383044-431316)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.189662 Xenopus laevis transcribed sequence with weak similarity more 78.53(n)    BI448982.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc562302 hypothetical protein MGC56230 76.5(n)   393184  BC046010.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ema1 endosomal maturation defective 56.81(n)
    54.85(a)
      41992  NM_142285.1  NP_650542.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gop-11 Protein GOP-1 44.62(n)
    38.04(a)
      175721  NM_065716.3  NP_498117.3 


    ENSEMBL Gene Tree for CLEC16A (if available)
    TreeFam Gene Tree for CLEC16A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6313 SNPs in CLEC16A are shown (see all 6313)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs787033071,2
    --10933443(+) GAATGC/GATGGT 2 -- us2k10--------
    rs1919633391,2
    --10933484(+) TACCAC/TTTCTA 2 -- us2k10--------
    rs455992411,2
    C,F--10933522(+) GGCTCA/G/TTGCAG 2 -- us2k12NA CSA 4
    rs759643241,2
    --10933523(+) GCTCAC/TGCAGA 2 -- us2k10--------
    rs791254361,2
    --10933560(+) AACGTC/GGTACT 2 -- us2k10--------
    rs1828866801,2
    --10933588(+) TTCTGA/GCTGAA 2 -- us2k10--------
    rs178029271,2
    C,F,H--10933650(+) CATCCA/GGCCTT 2 -- us2k122Minor allele frequency- G:0.14NA NS EA WA 2778
    rs798456181,2
    F--10933768(+) GTTATC/GTAGTG 2 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1390320181,2
    C--10933791(+) ATAAAA/GGGAAT 2 -- us2k10--------
    rs1928938171,2
    --10933868(+) GTAAGC/TCAACC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLEC16A (11038345 - 11276046 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CLEC16A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv273506CNV Insertion20981092
    esv270251CNV Insertion20981092
    dgv2603n71CNV Loss21882294
    nsv525548CNV Loss19592680
    nsv103022CNV Loss16902084

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLEC16A
    DNA2.0 Custom Variant and Variant Library Synthesis for CLEC16A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611303    OMIM disorders: --

    UniProtKB/Swiss-Prot: CL16A_HUMAN, Q2KHT3
  • Note=Insulin-dependent diabetes mellitus is significantly associated with variation within a 233-kb
    linkage disequilibrium block on chromosome 16p13 that includes KIAA0350. Three common non-coding variants of
    KIAA0350 in strong linkage disequilibrium reach genome-wide significance for association with the disease
    (PubMed:17632545)

  • 20/23 diseases for CLEC16A (see all 23):    About MalaCards
    interleukin-7 receptor alpha deficiency    multiple sclerosis    rheumatoid arthritis    diabetes mellitus
    arthritis    addison's disease    alopecia areata    primary biliary cirrhosis
    celiac disease    vasculitis    alopecia    allergic rhinitis
    rhinitis    type 1 diabetes    crohn's disease    kidney disease
    myocardial infarction    systemic lupus erythematosus    lupus erythematosus    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for CLEC16A:
    Multiple sclerosis

    CLEC16A for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLEC16A
    Human Genome Epidemiology (HuGE) Navigator: CLEC16A (40 documents)

    Export disorders for CLEC16A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLEC16A gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with CLEC16A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. (PubMed id 17632545)1, 2, 3, 4 Hakonarson H....Polychronakos C. (2007)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    3. Genome-wide association analysis of autoantibody posit ivity in type 1 diabetes cases. (PubMed id 21829393)1, 4 Plagnol V....Todd J.A. (2011)
    4. Genome-wide association study identifies 12 new susce ptibility loci for primary biliary cirrhosis. (PubMed id 21399635)1, 4 Mells G.F....Anderson C.A. (2011)
    5. A genome-wide meta-analysis of genetic variants associ ated with allergic rhinitis and grass sensitization and their interaction with b irth order. (PubMed id 22036096)1, 4 Ramasamy A....Jarvis D.L. (2011)
    6. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PubMed id 20095854)1, 4 Bhatti P....Sigurdson A.J. (2010)
    7. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    8. Genetic susceptibility to type 2 diabetes is associat ed with reduced prostate cancer risk. (PubMed id 20203524)1, 4 Pierce B.L. and Ahsan H. (2010)
    9. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    10. Genetic risk for myocardial infarction in Japanese in dividuals with or without chronic kidney disease. (PubMed id 20372818)1, 4 Fujimaki T....Yamada Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23274 HGNC: 29013 Ensembl:ENSG00000038532 euGenes: HUgn23274 ECgene: CLEC16A
    H-InvDB: CLEC16A

    (According to HUGE)
    About This Section
    HUGE: KIAA0350

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLEC16A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLEC16A gene:
    Search GeneIP for patents involving CLEC16A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CLEC16A
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CLEC16A   OriGene RNAi products in human, mouse, rat for CLEC16A  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CLEC16A  
     OriGene qSTAR qPCR primer pairs in human, mouse for CLEC16A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CLEC16A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLEC16A   OriGene Custom Protein Services for CLEC16A  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLEC16A
     QIAGEN SeqTarget long-range PCR primers for resequencing CLEC16A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC16A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC16A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC16A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC16A
     GenScript Custom Purified and Recombinant Proteins Services for CLEC16A GenScript cDNA clones with any tag delivered in your preferred vector for CLEC16A
     GenScript Custom Assay Services for CLEC16A GenScript Custom Superior Antibodies Services for CLEC16A
     GenScript Custom overexpressing Cell Line Services for CLEC16A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CLEC16A promoter
     Search Chromatin IP Primers for CLEC16A
     RT2 qPCR Primer Assay in human, mouse, rat CLEC16A
     Search GNC Networks for CLEC16A
     SABiosciences Custom PCR Arrays for CLEC16A
     Search Tocris compounds for CLEC16A (CL16A)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CLEC16A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CLEC16A antibodies
     Antibodies for CLEC16A
     See all of Abcam's Antibodies, Kits and Proteins for CLEC16A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CLEC16A
     Antibodies for CLEC16A
     ELISAs for CLEC16A
     CLIAs for CLEC16A
     Search LifeMap BioReagents cell lines for CLEC16A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC16A
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CLEC16A
     SwitchGear Promoter luciferase reporter plasmids for CLEC16A
     ThermoFisher Antibodies for CLEC16A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC16A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CLEC16A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLEC16A
    Customized:
     lentivirus for stable overexpression of CLEC16A
     lentivirus expression plasmids for stable overexpression of CLEC16A
     adenovirus for overexpression of CLEC16A
     LSBio Antibodies in human, mouse, rat for CLEC16A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CLEC16A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4