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Aliases for CLEC14A Gene

Aliases for CLEC14A Gene

  • C-Type Lectin Domain Family 14, Member A 2 3
  • Epidermal Growth Factor Receptor 5 3 4
  • C14orf27 3 4
  • EGFR-5 3 4
  • ClECT And EGF-Like Domain Containing Protein 3
  • C-Type Lectin Domain Family 14 Member A 3
  • Chromosome 14 Open Reading Frame 27 2
  • EGFR5 4
  • CEG1 3

External Ids for CLEC14A Gene

Previous HGNC Symbols for CLEC14A Gene

  • C14orf27

Previous GeneCards Identifiers for CLEC14A Gene

  • GC14M037794
  • GC14M038723
  • GC14M018838

Summaries for CLEC14A Gene

Entrez Gene Summary for CLEC14A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]

GeneCards Summary for CLEC14A Gene

CLEC14A (C-Type Lectin Domain Family 14, Member A) is a Protein Coding gene. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD93.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC14A Gene

Genomics for CLEC14A Gene

Regulatory Elements for CLEC14A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLEC14A Gene

38,254,000 bp from pter
38,256,370 bp from pter
2,371 bases
Minus strand

Genomic View for CLEC14A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC14A Gene

Proteins for CLEC14A Gene

  • Protein details for CLEC14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 14 member A
    Protein Accession:
    Secondary Accessions:
    • Q695G9
    • Q6PWT6
    • Q8N5V5

    Protein attributes for CLEC14A Gene

    490 amino acids
    Molecular mass:
    51636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC14A Gene

Proteomics data for CLEC14A Gene at MOPED

Post-translational modifications for CLEC14A Gene

  • Glycosylation at Asn189 and Asn381
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC14A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CLEC14A Gene

Domains for CLEC14A Gene

Gene Families for CLEC14A Gene

Protein Domains for CLEC14A Gene

Suggested Antigen Peptide Sequences for CLEC14A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
  • Contains 1 EGF-like domain.
genes like me logo Genes that share domains with CLEC14A: view

Function for CLEC14A Gene

Gene Ontology (GO) - Molecular Function for CLEC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC14A: view

Animal Model Products

miRNA for CLEC14A Gene

miRTarBase miRNAs that target CLEC14A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC14A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLEC14A Gene

Localization for CLEC14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC14A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CLEC14A Gene COMPARTMENTS Subcellular localization image for CLEC14A gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLEC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CLEC14A: view

Transcripts for CLEC14A Gene

mRNA/cDNA for CLEC14A Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(99) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC14A Gene

C-type lectin domain family 14, member A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC14A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC14A Gene

No ASD Table

Relevant External Links for CLEC14A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC14A Gene

mRNA expression in normal human tissues for CLEC14A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CLEC14A Gene

This gene is overexpressed in Lung (20.9), Heart (17.4), Urine (11.5), and Fetal heart (8.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CLEC14A Gene

SOURCE GeneReport for Unigene cluster for CLEC14A Gene Hs.525307

genes like me logo Genes that share expressions with CLEC14A: view

Expression partners for CLEC14A Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLEC14A Gene

Orthologs for CLEC14A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC14A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLEC14A 35
  • 81.97 (n)
  • 74.39 (a)
CLEC14A 36
  • 74 (a)
(Canis familiaris)
Mammalia CLEC14A 35
  • 86.04 (n)
  • 80.7 (a)
CLEC14A 36
  • 78 (a)
(Mus musculus)
Mammalia Clec14a 35
  • 73.7 (n)
  • 67.91 (a)
Clec14a 16
Clec14a 36
  • 66 (a)
(Pan troglodytes)
Mammalia CLEC14A 35
  • 99.46 (n)
  • 99.18 (a)
CLEC14A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Clec14a 35
  • 74.41 (n)
  • 66.45 (a)
(Anolis carolinensis)
Reptilia CLEC14A 36
  • 32 (a)
Species with no ortholog for CLEC14A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC14A Gene

Gene Tree for CLEC14A (if available)
Gene Tree for CLEC14A (if available)

Paralogs for CLEC14A Gene

Paralogs for CLEC14A Gene

genes like me logo Genes that share paralogs with CLEC14A: view

Variants for CLEC14A Gene

Sequence variations from dbSNP and Humsavar for CLEC14A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs913733 -- 38,253,822(+) AGTAA(A/G)CACTT downstream-variant-500B
rs1952562 -- 38,254,070(+) TCCTA(A/T)TTACT utr-variant-3-prime
rs1952564 -- 38,257,565(+) GGGTG(G/T)GAGGG upstream-variant-2KB
rs2812035 -- 38,256,080(+) AGGAC(A/G)CAGAG utr-variant-5-prime
rs2812036 -- 38,258,176(+) ATAAC(A/G)ACTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLEC14A Gene

Variant ID Type Subtype PubMed ID
nsv832773 CNV Loss 17160897
nsv456210 CNV Gain 19166990
nsv901653 CNV Loss 21882294

Relevant External Links for CLEC14A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC14A Gene

Disorders for CLEC14A Gene

Relevant External Links for CLEC14A

Genetic Association Database (GAD)

No disorders were found for CLEC14A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CLEC14A Gene

Publications for CLEC14A Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Cloning and characterization of a novel human ceg1 gene cDNA. (PMID: 15636369) Fu J.Q. … Li Y.P. (Shi Yan Sheng Wu Xue Bao 2004) 4 23

Products for CLEC14A Gene

Sources for CLEC14A Gene

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