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CLEC14A Gene

protein-coding   GIFtS: 48
GCID: GC14M038723

C-Type Lectin Domain Family 14, Member A

(Previous name: chromosome 14 open reading frame 27)
(Previous symbol: C14orf27)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C-Type Lectin Domain Family 14, Member A1 2     CEG12
C14orf271 2 3     C-Type Lectin Domain Family 14 Member A2
Epidermal Growth Factor Receptor 52 3     ClECT And EGF-Like Domain Containing Protein2
EGFR-52 3     EGFR53
Chromosome 14 Open Reading Frame 271     

External Ids:    HGNC: 198321   Entrez Gene: 1611982   Ensembl: ENSG000001764357   UniProtKB: Q86T133   

Export aliases for CLEC14A gene to outside databases

Previous GC identifers: GC14M037794 GC14M018838


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLEC14A Gene:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this
family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling,
glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in
cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due
to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a
candidate for tumor vascular targeting. (provided by RefSeq, Jan 2012)

GeneCards Summary for CLEC14A Gene:
CLEC14A (C-type lectin domain family 14, member A) is a protein-coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is THBD.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLEC14A gene promoter:
         AP-2rep   MZF-1   POU2F1   POU2F1a   CUTL1   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CLEC14A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC14A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.1   Ensembl cytogenetic band:  14q21.1   HGNC cytogenetic band: 14q21.1

CLEC14A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC14A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M038723:  view genomic region     (about GC identifiers)

Start:
38,723,308 bp from pter      End:
38,725,574 bp from pter
Size:
2,267 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CLC14_HUMAN, Q86T13 (See protein sequence)
Recommended Name: C-type lectin domain family 14 member A precursor  
Size: 490 amino acids; 51636 Da
Secondary accessions: Q695G9 Q6PWT6 Q8N5V5

Explore the universe of human proteins at neXtProt for CLEC14A: NX_Q86T13

Explore proteomics data for CLEC14A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn189, Asn381
  • Modification sites at PhosphoSitePlus

  • See CLEC14A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_778230.1  
    ENSEMBL proteins: 
     ENSP00000353013  

    CLEC14A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for CLEC14A
    OriGene Custom MassSpec
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    Novus Biologicals CLEC14A Protein
    Novus Biologicals CLEC14A Lysates
    Sino Biological Recombinant Protein for CLEC14A
    Sino Biological Cell Lysate for CLEC14A
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLEC14A

     
    Search eBioscience for Proteins for CLEC14A 

     
    antibodies-online proteins for CLEC14A (3 products) 

     
    antibodies-online peptides for CLEC14A

    CLEC14A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CLEC14A
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    Abcam antibodies for CLEC14A
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    ThermoFisher Antibodies for CLEC14A
    LSBio Antibodies in human, mouse, rat for CLEC14A
    antibodies-online antibodies for CLEC14A (22 products) 

    CLEC14A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CLEC14A
    Cloud-Clone Corp. CLIAs for CLEC14A
    Search eBioscience for ELISAs for CLEC14A 
    antibodies-online kits for CLEC14A (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLEC: C-type lectin domain containing

    4 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q86T13

    ProtoNet protein and cluster: Q86T13

    UniProtKB/Swiss-Prot: CLC14_HUMAN, Q86T13
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 EGF-like domain


    Find genes that share domains with CLEC14A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with CLEC14A           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Clec14a (no phenotypes)

    Find genes that share phenotypes with CLEC14A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Clec14atm1Lex for CLEC14A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLEC14A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLEC14A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC14A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLEC14A

    miRNA
    Products:
        
    miRTarBase miRNAs that target CLEC14A:
    hsa-mir-335-5p (MIRT018973)

    Block miRNA regulation of human, mouse, rat CLEC14A using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CLEC14A:
    hsa-miR-515-5p hsa-miR-124 hsa-miR-506 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidCLEC14A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLEC14A
    Predesigned siRNA for gene silencing in human, mouse, rat CLEC14A

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CLEC14A

    Clone
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    OriGene clones in human, mouse for CLEC14A (see all 7)
    OriGene ORF clones in mouse, rat for CLEC14A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLEC14A (NM_175060)
    Sino Biological Human cDNA Clone for CLEC14A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC14A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC14A

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CLEC14A
    Browse ESI BIO Cell Lines and PureStem Progenitors for CLEC14A 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC14A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLC14_HUMAN, Q86T13: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    cytosol1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CLEC14A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLEC14A (see all 22)
        MAPK Signaling
    Nuclear Receptor Activation by Vitamin-A
    Actin-Based Motility by Rho Family GTPases
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLEC14A
    Interactions:

        Search GeneGlobe Interaction Network for CLEC14A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLEC14A (CLC14)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLEC14A gene: 
    NM_175060.2  

    Unigene Cluster for CLEC14A:

    C-type lectin domain family 14, member A
    Hs.525307  [show with all ESTs]
    Unigene Representative Sequence: NM_175060
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000342213(uc001wum.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLEC14A using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CLEC14A:
    hsa-miR-515-5p hsa-miR-124 hsa-miR-506 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidCLEC14A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CLEC14A
    Predesigned siRNA for gene silencing in human, mouse, rat CLEC14A
    Clone
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    OriGene clones in human, mouse for CLEC14A (see all 7)
    OriGene ORF clones in mouse, rat for CLEC14A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLEC14A (NM_175060)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC14A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC14A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CLEC14A
    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC14A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLEC14A
      QuantiTect SYBR Green Assays in human, mouse, rat CLEC14A
      QuantiFast Probe-based Assays in human, mouse, rat CLEC14A

    Additional mRNA sequence: 

    AF161403.1 AY358395.1 AY573061.1 AY606132.1 BC031567.1 BX248017.1 

    3 DOTS entries:

    DT.100044380  DT.100785703  DT.100835139 

    Selected AceView cDNA sequences (see all 99):

    CR594082 BQ893009 NM_175060 BX334702 AI580084 AI307166 AY606132 AI359514 
    BX334701 AI582296 BG697162 AA904597 AL708670 AY358395 BF059395 BE501967 
    CA397021 BM664177 AW963001 BX248017 AA699611 AA968840 BU617867 AI278964 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLEC14A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCACTCCTG
    CLEC14A Expression
    About this image


    CLEC14A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Ovary (Reproductive System)
             Ovarian Somatic Cells Ovigerous Cord
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
    CLEC14A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLEC14A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525307
        Custom PCR Arrays for CLEC14A
    Primer
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    OriGene qPCR primer pairs and template standards for CLEC14A
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    QuantiFast Probe-based Assays in human, mouse, rat CLEC14A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC14A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC14A gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec14a1 , 5 C-type lectin domain family 14, member a1, 5 73.7(n)1
    67.91(a)1
      12 (25.65 cM)5
    668641  NM_025809.51  NP_080085.31 
     582647205 
    lizard
    (Anolis carolinensis)
    Reptilia CLEC14A6
    C-type lectin domain family 14, member A
    32(a)
    1 ↔ 1
    1(25961818-25962727)


    ENSEMBL Gene Tree for CLEC14A (if available)
    TreeFam Gene Tree for CLEC14A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLEC14A gene
    THBD2  CD932  CD2482  

    Find genes that share paralogs with CLEC14A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLEC14A (see all 124)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454451331,2
    Cuntested138724100(+) GAAATC/G/TACGCT 2 V syn11NA 4550
    rs1915738051,2
    --38722779(+) ATGCAC/GAAGAA 1 -- ds50010--------
    rs1840892781,2
    --38723020(+) GACATA/GAAGTA 1 -- ds50010--------
    rs9137331,2
    C,F,O,A,H--38723027(+) AGTAAA/GCACTT 1 -- ds500134Minor allele frequency- N:0.00NA EA MN NS CSA WA 4682
    rs19525621,2
    C,F,A,H--38723275(+) TCCTAA/TTTACT 1 -- ut3122Minor allele frequency- T:0.42EA NA NS CSA WA 3168
    rs1885744401,2
    --38723317(+) GTTATA/CAACAA 1 -- ut310--------
    rs1918403251,2
    --38723324(+) ACAATC/TCTTTA 1 -- ut310--------
    rs740459641,2
    C--38723425(+) AATTAT/CTTTTT 1 -- ut312Minor allele frequency- C:0.08WA 120
    rs1849791841,2
    --38723483(+) TCAATC/TACTTC 1 -- ut310--------
    rs1904146621,2
    --38723577(+) CACTTC/TCTCTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLEC14A (38723308 - 38725574 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CLEC14A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901653CNV Loss21882294
    nsv832773CNV Loss17160897
    nsv456210CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLEC14A
    DNA2.0 Custom Variant and Variant Library Synthesis for CLEC14A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with CLEC14A           About GenesLikeMe

    Genetic Association Database (GAD): CLEC14A

    Export disorders for CLEC14A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLEC14A gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with CLEC14A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    3. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Cloning and characterization of a novel human ceg1 gene cDNA. (PubMed id 15636369)2, 9 Fu J.Q.... Li Y.P. (Shi Yan Sheng Wu Xue Bao 2004)
    6. Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro. (PubMed id 23644659)1 Ki M.K....Lee S. (Oncogene 2013)
    7. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PubMed id 23319000)1 Luykx J.J....Ophoff R.A. (Mol. Psychiatry 2013)
    8. Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. (PubMed id 21706054)1 Mura M....Bicknell R. (Oncogene 2012)
    9. Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion. (PubMed id 21095181)1 Rho S.S....Kwon Y.G. (Biochem. Biophys. Res. Commun. 2011)
    10. Shear stress, tip cells and regulators of endothelial migration. (PubMed id 22103489)1 Zhuang X....Bicknell R. (Biochem. Soc. Trans. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 161198 HGNC: 19832 AceView: C14orf27 Ensembl:ENSG00000176435 euGenes: HUgn161198
    ECgene: CLEC14A H-InvDB: CLEC14A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLEC14A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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