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Aliases for CLEC14A Gene

Aliases for CLEC14A Gene

  • C-Type Lectin Domain Family 14 Member A 2 3 5
  • C-Type Lectin Domain Family 14, Member A 2 3
  • Epidermal Growth Factor Receptor 5 3 4
  • C14orf27 3 4
  • EGFR-5 3 4
  • ClECT And EGF-Like Domain Containing Protein 3
  • Chromosome 14 Open Reading Frame 27 2
  • EGFR5 4
  • CEG1 3

External Ids for CLEC14A Gene

Previous HGNC Symbols for CLEC14A Gene

  • C14orf27

Previous GeneCards Identifiers for CLEC14A Gene

  • GC14M037794
  • GC14M038723
  • GC14M018838

Summaries for CLEC14A Gene

Entrez Gene Summary for CLEC14A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]

GeneCards Summary for CLEC14A Gene

CLEC14A (C-Type Lectin Domain Family 14 Member A) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. GO annotations related to this gene include carbohydrate binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC14A Gene

Genomics for CLEC14A Gene

Regulatory Elements for CLEC14A Gene

Genomic Location for CLEC14A Gene

Chromosome:
14
Start:
38,254,000 bp from pter
End:
38,256,370 bp from pter
Size:
2,371 bases
Orientation:
Minus strand

Genomic View for CLEC14A Gene

Genes around CLEC14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC14A Gene

Proteins for CLEC14A Gene

  • Protein details for CLEC14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T13-CLC14_HUMAN
    Recommended name:
    C-type lectin domain family 14 member A
    Protein Accession:
    Q86T13
    Secondary Accessions:
    • Q695G9
    • Q6PWT6
    • Q8N5V5

    Protein attributes for CLEC14A Gene

    Size:
    490 amino acids
    Molecular mass:
    51636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC14A Gene

Proteomics data for CLEC14A Gene at MOPED

Post-translational modifications for CLEC14A Gene

  • Glycosylation at Asn 189 and Asn 381
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC14A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CLEC14A Gene

Domains & Families for CLEC14A Gene

Gene Families for CLEC14A Gene

Protein Domains for CLEC14A Gene

Suggested Antigen Peptide Sequences for CLEC14A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86T13

UniProtKB/Swiss-Prot:

CLC14_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 1 EGF-like domain.
genes like me logo Genes that share domains with CLEC14A: view

Function for CLEC14A Gene

Phenotypes for CLEC14A Gene

genes like me logo Genes that share phenotypes with CLEC14A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC14A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC14A Gene

Localization for CLEC14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC14A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC14A Gene COMPARTMENTS Subcellular localization image for CLEC14A gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLEC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CLEC14A: view

Pathways & Interactions for CLEC14A Gene

genes like me logo Genes that share pathways with CLEC14A: view

Pathways by source for CLEC14A Gene

Interacting Proteins for CLEC14A Gene

Gene Ontology (GO) - Biological Process for CLEC14A Gene

None

No data available for SIGNOR curated interactions for CLEC14A Gene

Drugs & Compounds for CLEC14A Gene

No Compound Related Data Available

Transcripts for CLEC14A Gene

mRNA/cDNA for CLEC14A Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(99) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC14A Gene

C-type lectin domain family 14, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC14A Gene

No ASD Table

Relevant External Links for CLEC14A Gene

GeneLoc Exon Structure for
CLEC14A
ECgene alternative splicing isoforms for
CLEC14A

Expression for CLEC14A Gene

mRNA expression in normal human tissues for CLEC14A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLEC14A Gene

This gene is overexpressed in Lung (20.9), Heart (17.4), Urine (11.5), and Fetal heart (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC14A Gene



SOURCE GeneReport for Unigene cluster for CLEC14A Gene Hs.525307

genes like me logo Genes that share expression patterns with CLEC14A: view

Protein tissue co-expression partners for CLEC14A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLEC14A Gene

Orthologs for CLEC14A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC14A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLEC14A 35
  • 81.97 (n)
  • 74.39 (a)
CLEC14A 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC14A 35
  • 86.04 (n)
  • 80.7 (a)
CLEC14A 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec14a 35
  • 73.7 (n)
  • 67.91 (a)
Clec14a 16
Clec14a 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLEC14A 35
  • 99.46 (n)
  • 99.18 (a)
CLEC14A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clec14a 35
  • 74.41 (n)
  • 66.45 (a)
lizard
(Anolis carolinensis)
Reptilia CLEC14A 36
  • 32 (a)
OneToOne
Species with no ortholog for CLEC14A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC14A Gene

ENSEMBL:
Gene Tree for CLEC14A (if available)
TreeFam:
Gene Tree for CLEC14A (if available)

Paralogs for CLEC14A Gene

No data available for Paralogs for CLEC14A Gene

Variants for CLEC14A Gene

Sequence variations from dbSNP and Humsavar for CLEC14A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs913733 -- 38,253,822(+) AGTAA(A/G)CACTT downstream-variant-500B
rs1952562 -- 38,254,070(+) TCCTA(A/T)TTACT utr-variant-3-prime
rs74045964 -- 38,254,220(+) AATTA(C/T)TTTTT utr-variant-3-prime
rs184089278 -- 38,253,815(+) GACAT(A/G)AAGTA downstream-variant-500B
rs191573805 -- 38,253,574(+) ATGCA(C/G)AAGAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CLEC14A Gene

Variant ID Type Subtype PubMed ID
nsv832773 CNV Loss 17160897
nsv456210 CNV Gain 19166990
nsv901653 CNV Loss 21882294

Variation tolerance for CLEC14A Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC14A Gene

HapMap Linkage Disequilibrium report
CLEC14A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC14A Gene

Disorders for CLEC14A Gene

Relevant External Links for CLEC14A

Genetic Association Database (GAD)
CLEC14A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC14A

No disorders were found for CLEC14A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC14A Gene

Publications for CLEC14A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth. (PMID: 25745997) Noy P.J. … Bicknell R. (Oncogene 2015) 3
  3. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PMID: 23319000) Luykx J.J. … Ophoff R.A. (Mol. Psychiatry 2013) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro. (PMID: 23644659) Ki M.K. … Lee S. (Oncogene 2013) 3

Products for CLEC14A Gene

Sources for CLEC14A Gene

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