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Aliases for CLEC14A Gene

Aliases for CLEC14A Gene

  • C-Type Lectin Domain Family 14 Member A 2 3 5
  • Epidermal Growth Factor Receptor 5 3 4
  • C14orf27 3 4
  • EGFR-5 3 4
  • ClECT And EGF-Like Domain Containing Protein 3
  • C-Type Lectin Domain Family 14, Member A 2
  • Chromosome 14 Open Reading Frame 27 2
  • EGFR5 4
  • CEG1 3

External Ids for CLEC14A Gene

Previous HGNC Symbols for CLEC14A Gene

  • C14orf27

Previous GeneCards Identifiers for CLEC14A Gene

  • GC14M037794
  • GC14M038723
  • GC14M018838

Summaries for CLEC14A Gene

Entrez Gene Summary for CLEC14A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]

GeneCards Summary for CLEC14A Gene

CLEC14A (C-Type Lectin Domain Family 14 Member A) is a Protein Coding gene. Among its related pathways are Phospholipase-C Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD93.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC14A Gene

Genomics for CLEC14A Gene

Regulatory Elements for CLEC14A Gene

Enhancers for CLEC14A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F038063 1.1 FANTOM5 Ensembl ENCODE 10.4 +191.2 191233 3.2 CTCF RFX1 CLEC14A LOC105370456 ENSG00000258649
GH14F038206 0.9 ENCODE 10.7 +47.3 47252 4.5 TBP ZNF133 ZNF48 RAD21 YY1 ZNF207 SMARCC2 FOS ZNF202 ZNF263 PNN CLEC14A GC14P038209 SSTR1
GH14F038289 0.8 ENCODE 11.9 -34.7 -34741 2.6 JUN MAX RAD21 ZBTB40 RFX5 RCOR1 FOS MAFK TCF7L2 NFE2L2 CLEC14A SSTR1 ENSG00000259072 PIR41157
GH14F038253 0.7 ENCODE 12.1 +0.5 455 4.4 CTCF PKNOX1 JUN RAD21 POLR2A FOS MAFK EZH2 CBX2 CEBPB CLEC14A SSTR1 GC14M038256 PIR37390
GH14F038196 0.7 ENCODE 10.7 +59.4 59397 1.1 PAF1 CTCF ZNF384 SUPT20H EBF1 RAD21 POLR2A ZNF143 SMC3 MAFK CLEC14A SSTR1 ENSG00000259048
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLEC14A on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC14A Gene

38,254,000 bp from pter
38,256,370 bp from pter
2,371 bases
Minus strand

Genomic View for CLEC14A Gene

Genes around CLEC14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC14A Gene

Proteins for CLEC14A Gene

  • Protein details for CLEC14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 14 member A
    Protein Accession:
    Secondary Accessions:
    • Q695G9
    • Q6PWT6
    • Q8N5V5

    Protein attributes for CLEC14A Gene

    490 amino acids
    Molecular mass:
    51636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC14A Gene

Post-translational modifications for CLEC14A Gene

  • Glycosylation at Asn 189 and Asn 381
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC14A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLEC14A Gene

Domains & Families for CLEC14A Gene

Gene Families for CLEC14A Gene

Protein Domains for CLEC14A Gene

Suggested Antigen Peptide Sequences for CLEC14A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
  • Contains 1 EGF-like domain.
genes like me logo Genes that share domains with CLEC14A: view

Function for CLEC14A Gene

Gene Ontology (GO) - Molecular Function for CLEC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
GO:1990430 extracellular matrix protein binding IDA 25745997
genes like me logo Genes that share ontologies with CLEC14A: view

Phenotypes for CLEC14A Gene

genes like me logo Genes that share phenotypes with CLEC14A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC14A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC14A Gene

Localization for CLEC14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC14A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC14A gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CLEC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IDA 25745997
GO:0016021 integral component of membrane IEA --
GO:0031012 extracellular matrix IDA 23979707
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CLEC14A: view

Pathways & Interactions for CLEC14A Gene

genes like me logo Genes that share pathways with CLEC14A: view

Interacting Proteins for CLEC14A Gene

Gene Ontology (GO) - Biological Process for CLEC14A Gene


No data available for SIGNOR curated interactions for CLEC14A Gene

Transcripts for CLEC14A Gene

mRNA/cDNA for CLEC14A Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(99) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC14A Gene

C-type lectin domain family 14, member A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC14A Gene

No ASD Table

Relevant External Links for CLEC14A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC14A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLEC14A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLEC14A Gene

This gene is overexpressed in Lung (20.9), Heart (17.4), Urine (11.5), and Fetal heart (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC14A Gene

Protein tissue co-expression partners for CLEC14A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLEC14A Gene:


SOURCE GeneReport for Unigene cluster for CLEC14A Gene:

genes like me logo Genes that share expression patterns with CLEC14A: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLEC14A Gene

Orthologs for CLEC14A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC14A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLEC14A 34 35
  • 99.46 (n)
(Canis familiaris)
Mammalia CLEC14A 34 35
  • 86.04 (n)
(Bos Taurus)
Mammalia CLEC14A 34 35
  • 81.97 (n)
(Rattus norvegicus)
Mammalia Clec14a 34
  • 74.41 (n)
(Mus musculus)
Mammalia Clec14a 34 16 35
  • 73.7 (n)
(Anolis carolinensis)
Reptilia CLEC14A 35
  • 32 (a)
Species where no ortholog for CLEC14A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC14A Gene

Gene Tree for CLEC14A (if available)
Gene Tree for CLEC14A (if available)

Paralogs for CLEC14A Gene

Paralogs for CLEC14A Gene

genes like me logo Genes that share paralogs with CLEC14A: view

Variants for CLEC14A Gene

Sequence variations from dbSNP and Humsavar for CLEC14A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs112144257 -- 38,254,708(+) CGGGC(C/T)CATAG reference, missense
rs112164301 -- 38,256,896(+) GACCA(C/T)AGATC upstream-variant-2KB
rs112354022 -- 38,254,846(+) GGAGT(C/T)GAAAG reference, missense
rs113776316 -- 38,255,721(+) AGTGG(A/G)AACGC reference, missense
rs113953690 -- 38,255,058(+) CGACC(C/G)TGATT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CLEC14A Gene

Variant ID Type Subtype PubMed ID
nsv456210 CNV gain 19166990
nsv564399 CNV gain 21841781
nsv832773 CNV loss 17160897

Variation tolerance for CLEC14A Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC14A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC14A Gene

Disorders for CLEC14A Gene

Relevant External Links for CLEC14A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLEC14A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC14A Gene

Publications for CLEC14A Gene

  1. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Cloning and characterization of a novel human ceg1 gene cDNA. (PMID: 15636369) Fu J.Q. … Li Y.P. (Shi Yan Sheng Wu Xue Bao 2004) 4 22 64
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for CLEC14A Gene

Sources for CLEC14A Gene

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