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Aliases for CLEC14A Gene

Aliases for CLEC14A Gene

  • C-Type Lectin Domain Containing 14A 2 3 5
  • C-Type Lectin Domain Family 14 Member A 2 3
  • Epidermal Growth Factor Receptor 5 3 4
  • C14orf27 3 4
  • EGFR-5 3 4
  • ClECT And EGF-Like Domain Containing Protein 3
  • C-Type Lectin Domain Family 14, Member A 2
  • Chromosome 14 Open Reading Frame 27 2
  • EGFR5 4
  • CEG1 3

External Ids for CLEC14A Gene

Previous HGNC Symbols for CLEC14A Gene

  • C14orf27

Previous GeneCards Identifiers for CLEC14A Gene

  • GC14M037794
  • GC14M038723
  • GC14M018838

Summaries for CLEC14A Gene

Entrez Gene Summary for CLEC14A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]

GeneCards Summary for CLEC14A Gene

CLEC14A (C-Type Lectin Domain Containing 14A) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include carbohydrate binding.

Additional gene information for CLEC14A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC14A Gene

Genomics for CLEC14A Gene

Regulatory Elements for CLEC14A Gene

Enhancers for CLEC14A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H038063 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +191.2 191233 3.2 CTCF RFX1 CLEC14A LOC105370456 ENSG00000258649
GH14H038289 1 Ensembl ENCODE 11.9 -34.7 -34741 2.6 FOXA2 JUN MAX RAD21 RFX5 RCOR1 FOS MAFK TCF7L2 NFE2L2 CLEC14A SSTR1 ENSG00000259072 PIR41157
GH14H038253 0.9 ENCODE dbSUPER 12.1 +0.5 455 4.4 CTCF FOXA2 JUN CEBPB EP300 RAD21 NR2F2 MAFF JUND POLR2A CLEC14A SSTR1 PIR37390 GC14M038256
GH14H038197 1 ENCODE dbSUPER 10.4 +57.1 57091 3 TBP CTCF JUN MAX RAD21 BRCA1 POLR2A SMC3 CHD2 CEBPB CLEC14A SSTR1 ENSG00000259048
GH14H038206 0.9 ENCODE 10.8 +47.3 47252 4.5 TBP ZNF133 RAD21 YY1 ZNF207 SMARCC2 FOS PAF1 ZNF202 SMARCC1 PNN CLEC14A SSTR1 GC14P038209
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLEC14A on UCSC Golden Path with GeneCards custom track

Promoters for CLEC14A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000274201 670 601 POLR2A CTBP2 EZH2
ENSR00000067828 1469 600 CTBP2 EZH2

Genomic Locations for CLEC14A Gene

Genomic Locations for CLEC14A Gene
2,371 bases
Minus strand

Genomic View for CLEC14A Gene

Genes around CLEC14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC14A Gene

Proteins for CLEC14A Gene

  • Protein details for CLEC14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 14 member A
    Protein Accession:
    Secondary Accessions:
    • Q695G9
    • Q6PWT6
    • Q8N5V5

    Protein attributes for CLEC14A Gene

    490 amino acids
    Molecular mass:
    51636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC14A Gene

Post-translational modifications for CLEC14A Gene

  • Glycosylation at posLast=189189 and Asn381
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC14A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLEC14A Gene

Domains & Families for CLEC14A Gene

Gene Families for CLEC14A Gene

Protein Domains for CLEC14A Gene

Suggested Antigen Peptide Sequences for CLEC14A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLEC14A: view

No data available for UniProtKB/Swiss-Prot for CLEC14A Gene

Function for CLEC14A Gene

Phenotypes From GWAS Catalog for CLEC14A Gene

Gene Ontology (GO) - Molecular Function for CLEC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
GO:1990430 extracellular matrix protein binding IDA 25745997
genes like me logo Genes that share ontologies with CLEC14A: view

Phenotypes for CLEC14A Gene

genes like me logo Genes that share phenotypes with CLEC14A: view

Animal Models for CLEC14A Gene

MGI Knock Outs for CLEC14A:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLEC14A Gene

Localization for CLEC14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC14A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC14A gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CLEC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IDA 25745997
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031012 extracellular matrix IDA 23979707
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CLEC14A: view

Pathways & Interactions for CLEC14A Gene

genes like me logo Genes that share pathways with CLEC14A: view

Interacting Proteins for CLEC14A Gene

Gene Ontology (GO) - Biological Process for CLEC14A Gene


No data available for SIGNOR curated interactions for CLEC14A Gene

Drugs & Compounds for CLEC14A Gene

(1) Drugs for CLEC14A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Resveratrol Experimental, Investigational Pharma Target 123
genes like me logo Genes that share compounds with CLEC14A: view

Transcripts for CLEC14A Gene

mRNA/cDNA for CLEC14A Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(99) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLEC14A Gene

C-type lectin domain family 14, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC14A Gene

No ASD Table

Relevant External Links for CLEC14A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC14A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLEC14A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLEC14A Gene

This gene is overexpressed in Lung (20.9), Heart (17.4), Urine (11.5), and Fetal heart (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC14A Gene

Protein tissue co-expression partners for CLEC14A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLEC14A Gene:


SOURCE GeneReport for Unigene cluster for CLEC14A Gene:


Evidence on tissue expression from TISSUES for CLEC14A Gene

  • Liver(4.2)
  • Nervous system(4.2)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with CLEC14A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC14A Gene

Orthologs for CLEC14A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC14A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLEC14A 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia CLEC14A 33 34
  • 86.04 (n)
(Bos Taurus)
Mammalia CLEC14A 33 34
  • 81.97 (n)
(Rattus norvegicus)
Mammalia Clec14a 33
  • 74.41 (n)
(Mus musculus)
Mammalia Clec14a 33 16 34
  • 73.7 (n)
(Anolis carolinensis)
Reptilia CLEC14A 34
  • 32 (a)
Species where no ortholog for CLEC14A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC14A Gene

Gene Tree for CLEC14A (if available)
Gene Tree for CLEC14A (if available)

Paralogs for CLEC14A Gene

No data available for Paralogs for CLEC14A Gene

Variants for CLEC14A Gene

Sequence variations from dbSNP and Humsavar for CLEC14A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000613300 -- 38,256,467(+) AGGAA(A/G)GACTT upstream-variant-2KB
rs1002862941 -- 38,256,010(+) GGCGA(A/G)CGCCG reference, missense
rs1003004217 -- 38,254,908(+) CTGAT(G/T)GGGTG reference, missense
rs1003512102 -- 38,255,762(+) TCTTT(A/G)GAGCC reference, synonymous-codon
rs1005351308 -- 38,258,232(+) AGAGT(C/T)AGAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLEC14A Gene

Variant ID Type Subtype PubMed ID
nsv832773 CNV loss 17160897
nsv564399 CNV gain 21841781
nsv456210 CNV gain 19166990

Variation tolerance for CLEC14A Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC14A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC14A Gene

Disorders for CLEC14A Gene

Relevant External Links for CLEC14A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLEC14A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC14A Gene

Publications for CLEC14A Gene

  1. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. [Cloning and characterization of a novel human ceg1 gene cDNA]. (PMID: 15636369) Fu JQ … Li YP (Shi yan sheng wu xue bao 2004) 4 22 60
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 60
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60

Products for CLEC14A Gene

Sources for CLEC14A Gene

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