CLEC14A Gene
protein-coding GIFtS : 45
GCID: GC14 M038723
C-type lectin domain family 14, member A (Previous name: chromosome 14 open reading frame 27 ) (Previous symbol: C14orf27 )
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Aliasesfor CLEC14A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases C-Type Lectin Domain Family 14, Member A 1 2 CEG12 C14orf271 2 3 C-Type Lectin Domain Family 14 Member A2 Epidermal Growth Factor Receptor 52 3 ClECT And EGF-Like Domain Containing Protein2 EGFR-52 3 EGFR53 Chromosome 14 Open Reading Frame 271
Export aliases for CLEC14A gene to outside databases Previous GC identifers: GC14M037794 GC14M018838
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Summariesfor CLEC14A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CLEC14A : This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. (provided by RefSeq, Jan 2012)
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Genomic Viewsfor CLEC14A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CLEC14A gene promoter: AP-2rep MZF-1 POU2F1 POU2F1a CUTL1 RSRFC4 Other transcription factors Search SABiosciences Chromatin IP Primers for CLEC14A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CLEC14A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q21.1 Ensembl cytogenetic band: 14q21.1 HGNC cytogenetic band: 14q21.1 CLEC14A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M038723: view genomic region
(about GC identifiers )
Start:
38,723,308 bp from pter
End:
38,725,574 bp from pter
Size:
2,267 bases
Orientation:
minus strand
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Proteinsfor CLEC14A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CLC14_HUMAN, Q86T13 (See
protein sequence )Recommended Name: C-type lectin domain family 14 member A precursor Size : 490 amino acids; 51636 Da
Subcellular location : Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions : Q695G9 Q6PWT6 Q8N5V5Explore the universe of human proteins at neXtProt for CLEC14A: NX_Q86T13 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q86T13 CLEC14A Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_778230.1 ENSEMBL proteins: ENSP00000353013 Human Recombinant Protein Products for CLEC14A: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
CLEC14A for ontologies About GeneDecksing CLEC14A Antibody Products: Assay Products for CLEC14A:
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Protein
Domains / Familiesfor CLEC14A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CLEC14A for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q86T13 ProtoNet protein and cluster: Q86T13
UniProtKB/Swiss-Prot: CLC14_HUMAN, Q86T13 Similarity : Contains 1 C-type lectin domainSimilarity : Contains 1 EGF-like domain
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Functionfor CLEC14A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0030246 carbohydrate binding
IEA --
CLEC14A for ontologies About GeneDecksing Phenotypes: 1 MGI phenotypic allele for Clec14a (no phenotypes)
CLEC14A for phenotypes About GeneDecksing Animal Models: Mouse knock-out Clec14a tm1Lex for CLEC14AClone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CLEC14A (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CLEC14A (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CLEC14A (NM_175060 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLEC14A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CLEC14A
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC14A
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Pathways & Interactionsfor CLEC14A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC14A
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Drugs & Compoundsfor CLEC14A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CLEC14A Search CenterWatch for drugs/clinical trials and news about CLEC14A / CLC14
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Transcriptsfor CLEC14A gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CLEC14A gene: NM_175060.2 Unigene Cluster for CLEC14A:
C-type lectin domain family 14, member A Hs.525307 [show with all ESTs ] Unigene Representative Sequence: NM_175060 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000342213 (uc001wum.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CLEC14A (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CLEC14A (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CLEC14A (NM_175060 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLEC14A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CLEC14A
Additional cDNA sequence: AF161403.1 AY358395.1 AY573061.1 AY606132.1 BC031567.1 BX248017.1
3 DOTS entries : DT.100044380 DT.100785703
DT.100835139 24/99 AceView cDNA sequences (see all 99 ):
AI582296 AI580084 AA968840 AA904597 AW770514 AI359514 BM664177 AA699611 BE219310 CR594082 CA397021 AY358395 BX248017 AW963001 BM710225 BQ893009 AI278964 BG697162 BF059395 BU617867 BQ002335 BX334702 BQ575388 BQ024483 GeneLoc Exon Structure
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Expression for CLEC14A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CLEC14A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGCACTCCTGAbout this image CLEC14A expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See CLEC14A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CLEC14A SOURCE GeneReport for Unigene cluster: Hs.525307 SABiosciences Custom PCR Arrays for CLEC14A Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CLEC14ABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CLEC14A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CLEC14A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CLEC14A In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC14A
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Orthologsfor CLEC14A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for CLEC14A gene from 2/13 species (see all 13 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
zebrafish (Danio rerio)
Actinopterygii
CABZ01075689.16
--
1 → many
22(4162619-4176901)
worm (Caenorhabditis elegans)
Secernentea
fbn-16
FiBrilliN homolog family member (fbn-1)
3(a)
1 → many
III(7625311-7640988)
ENSEMBL Gene Tree for CLEC14A (if available)TreeFam Gene Tree for CLEC14A (if available)
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Paralogsfor CLEC14A gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CLEC14A gene THBD 2 CD93 2 CD248 2
CLEC14A for paralogs About GeneDecksing
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Genomic Variantsfor CLEC14A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 14 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CLEC14A (38723308 - 38725574 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CLEC14A: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CLEC14A
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Disorders
/ Diseasesfor CLEC14A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CLEC14A for disorders About GeneDecksing 1 disease for CLEC14A : About MalaCards vaccinia Export disorders for CLEC14A gene to outside databases
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Publicationsfor CLEC14A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CLEC14A gene integrated from 9 sources : (articles sorted by number of sources associating them with CLEC14A) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161) 1 , 2 Zhang Z. and Henzel W.J. (2004) The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121) 1 , 2 Heilig R.... Weissenbach J. (2003) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) Cloning and characterization of a novel human ceg1 gene cDNA. (PubMed id 15636369) 2 , 9 Fu J.Q.... Li Y.P. (2004) Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. (PubMed id 21706054) 1 Mura M....Bicknell R. (2012) Clec14a is specifically expressed in endothelial cell s and mediates cell to cell adhesion. (PubMed id 21095181) 1 Rho S.S....Kwon Y.G. (2011) Shear stress, tip cells and regulators of endothelial migration. (PubMed id 22103489) 1 Zhuang X....Bicknell R. (2011) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Yeast-based genetic system for functional analysis of poxvirus mRNA cap methyltransferase. (PubMed id 12805428) 9 Saha N....Schwer B. (2003)
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External Searches for CLEC14A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CLEC14A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CLEC14A gene
(According to HUGE )
About This Section --
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Specialized Databases showing CLEC14A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CLEC14A Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CLEC14A gene: Search GeneIP for patents involving CLEC14A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CLEC14A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CLEC14A OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CLEC14A OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CLEC14A OriGene Protein Over-expression Lysate for CLEC14A Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CLEC14A OriGene 3'-UTR Clone for CLEC14A OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CLEC14A OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CLEC14A Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CLEC14A OriGene Custom Protein Services for CLEC14A OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLEC14A QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CLEC14A QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CLEC14A QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CLEC14A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CLEC14A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CLEC14A
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC14A
ThermoFisher Antibodies for CLEC14A
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CLEC14A
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