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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC14A Gene

protein-coding   GIFtS: 46
GCID: GC14M038723

C-Type Lectin Domain Family 14, Member A

(Previous name: chromosome 14 open reading frame 27)
(Previous symbol: C14orf27)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 14, Member A1 2     CEG12
C14orf271 2 3     C-Type Lectin Domain Family 14 Member A2
Epidermal Growth Factor Receptor 52 3     ClECT And EGF-Like Domain Containing Protein2
EGFR-52 3     EGFR53
Chromosome 14 Open Reading Frame 271     

External Ids:    HGNC: 198321   Entrez Gene: 1611982   Ensembl: ENSG000001764357   UniProtKB: Q86T133   

Export aliases for CLEC14A gene to outside databases

Previous GC identifers: GC14M037794 GC14M018838


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLEC14A Gene:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this
family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling,
glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in
cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due
to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a
candidate for tumor vascular targeting. (provided by RefSeq, Jan 2012)

GeneCards Summary for CLEC14A Gene: 
CLEC14A (C-type lectin domain family 14, member A) is a protein-coding gene. Diseases associated with CLEC14A include vaccinia, and endotheliitis. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is THBD.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC14A gene promoter:
         AP-2rep   MZF-1   POU2F1   POU2F1a   CUTL1   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CLEC14A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC14A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.1   Ensembl cytogenetic band:  14q21.1   HGNC cytogenetic band: 14q21.1

CLEC14A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC14A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M038723:  view genomic region     (about GC identifiers)

Start:
38,723,308 bp from pter      End:
38,725,574 bp from pter
Size:
2,267 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLC14_HUMAN, Q86T13 (See protein sequence)
Recommended Name: C-type lectin domain family 14 member A precursor  
Size: 490 amino acids; 51636 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: Q695G9 Q6PWT6 Q8N5V5

Explore the universe of human proteins at neXtProt for CLEC14A: NX_Q86T13

Explore proteomics data for CLEC14A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86T13

  • CLEC14A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLEC14A Protein Expression
    REFSEQ proteins: NP_778230.1  
    ENSEMBL proteins: 
     ENSP00000353013  

    Human Recombinant Protein Products for CLEC14A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
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    OriGene Protein Over-expression Lysate for CLEC14A
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    OriGene Custom Protein Services for CLEC14A
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    Novus Biologicals CLEC14A Protein
    Novus Biologicals CLEC14A Lysates
    Sino Biological Recombinant Protein for CLEC14A
    Sino Biological Cell Lysate for CLEC14A 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLEC14A 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    CLEC14A for ontologies           About GeneDecksing



    CLEC14A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CLEC14A
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    LSBio Antibodies in human, mouse, rat for CLEC14A 

    Assay Products for CLEC14A: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CLEC14A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLEC14A 
    Cloud-Clone Corp. CLIAs for CLEC14A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLEC: C-type lectin domain containing

    4 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q86T13

    ProtoNet protein and cluster: Q86T13

    UniProtKB/Swiss-Prot: CLC14_HUMAN, Q86T13
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 EGF-like domain


    CLEC14A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding IEA--
         
    CLEC14A for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Clec14a (no phenotypes)

    CLEC14A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Clec14atm1Lex for CLEC14A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLEC14A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLEC14A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC14A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLEC14A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC14A
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CLEC14A:
    hsa-miR-515-5p hsa-miR-124 hsa-miR-506 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidCLEC14A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLEC14A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC14A

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CLEC14A
    Sirion Biotech Customized adenovirus for overexpression of CLEC14A

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CLEC14A (see all 8)
    OriGene ORF clones in mouse, rat for CLEC14A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLEC14A (NM_175060)
    Sino Biological Human cDNA Clone for CLEC14A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC14A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC14A
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                         Customized lentivirus expression plasmids for stable overexpression of CLEC14A 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CLEC14A
    Search LifeMap BioReagents cell lines for CLEC14A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC14A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC14A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLEC14A (CLC14)

    Search CenterWatch for drugs/clinical trials and news about CLEC14A / CLC14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLEC14A gene: 
    NM_175060.2  

    Unigene Cluster for CLEC14A:

    C-type lectin domain family 14, member A
    Hs.525307  [show with all ESTs]
    Unigene Representative Sequence: NM_175060
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000342213(uc001wum.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC14A
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CLEC14A:
    hsa-miR-515-5p hsa-miR-124 hsa-miR-506 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidCLEC14A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLEC14A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC14A
    Clone
    Products:
         
    OriGene clones in human, mouse for CLEC14A (see all 8)
    OriGene ORF clones in mouse, rat for CLEC14A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLEC14A (NM_175060)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC14A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC14A
    Sirion Biotech Customized lentivirus for stable overexpression of CLEC14A 
                         Customized lentivirus expression plasmids for stable overexpression of CLEC14A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CLEC14A
    OriGene qSTAR qPCR primer pairs in human, mouse for CLEC14A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC14A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC14A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC14A

    Additional mRNA sequence: 

    AF161403.1 AY358395.1 AY573061.1 AY606132.1 BC031567.1 BX248017.1 

    3 DOTS entries:

    DT.100044380  DT.100785703  DT.100835139 

    24/99 AceView cDNA sequences (see all 99):

    AW963001 BQ024483 BQ893009 NM_175060 BM664177 BE501967 AI580084 AY606132 
    AL708670 BF059395 AL704955 BQ002335 BM710225 AI359514 AW770514 BC031567 
    CR594082 BG697162 BU617867 AI278964 AA968840 BX334701 BQ575388 CA397021 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLEC14A expression in normal human tissues (normalized intensities)      CLEC14A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCACTCCTG
    CLEC14A Expression
    About this image


    CLEC14A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 24 entries
             PureStem endothelial progenitor 30-SM2-1
             Human Pulmonary Microvascular Endothelial Cells (HPMEC)   
     
     Fibroblast (Uncategorized)    fully expand to see all 5 entries
             Human Lymphatic Fibroblasts (HLF)   
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             heart muscle ; myocytes   
     
     Intestine
             small intestine ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Human Pulmonary Microvascular Endothelial Cells (HPMEC)   

    See CLEC14A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLEC14A

    SOURCE GeneReport for Unigene cluster: Hs.525307
        SABiosciences Custom PCR Arrays for CLEC14A
    Primer
    Products:
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC14A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC14A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC14A gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec14a1 , 5 C-type lectin domain family 14, member a1, 5 73.7(n)1
    67.91(a)1
      12 (25.65 cM)5
    668641  NM_025809.51  NP_080085.31 
     582647205 
    lizard
    (Anolis carolinensis)
    Reptilia CLEC14A6
    Uncharacterized protein
    30(a)
    1 ↔ 1
    1(25961818-25962727)


    ENSEMBL Gene Tree for CLEC14A (if available)
    TreeFam Gene Tree for CLEC14A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLEC14A gene
    THBD2  CD932  CD2482  

    CLEC14A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/124 SNPs in CLEC14A are shown (see all 124)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454451331,2
    Cuntested138724100(+) GAAATC/G/TACGCT 2 V syn11NA 4550
    rs1915738051,2
    --38722779(+) ATGCAC/GAAGAA 1 -- ds50010--------
    rs1840892781,2
    --38723020(+) GACATA/GAAGTA 1 -- ds50010--------
    rs9137331,2
    C,F,O,A,H--38723027(+) AGTAAA/GCACTT 1 -- ds500134Minor allele frequency- N:0.00NA EA MN NS CSA WA 4682
    rs19525621,2
    C,F,A,H--38723275(+) TCCTAA/TTTACT 1 -- ut3122Minor allele frequency- T:0.42EA NA NS CSA WA 3168
    rs1885744401,2
    --38723317(+) GTTATA/CAACAA 1 -- ut310--------
    rs1918403251,2
    --38723324(+) ACAATC/TCTTTA 1 -- ut310--------
    rs740459641,2
    C--38723425(+) AATTAT/CTTTTT 1 -- ut312Minor allele frequency- C:0.08WA 120
    rs1849791841,2
    --38723483(+) TCAATC/TACTTC 1 -- ut310--------
    rs1904146621,2
    --38723577(+) CACTTC/TCTCTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLEC14A (38723308 - 38725574 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CLEC14A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv901653CNV Loss21882294
    nsv832773CNV Loss17160897
    nsv456210CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLEC14A
    DNA2.0 Custom Variant and Variant Library Synthesis for CLEC14A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CLEC14A:    About MalaCards
    vaccinia    endotheliitis


    CLEC14A for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLEC14A

    Export disorders for CLEC14A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLEC14A gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CLEC14A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    3. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Cloning and characterization of a novel human ceg1 gene cDNA. (PubMed id 15636369)2, 9 Fu J.Q.... Li Y.P. (2004)
    6. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PubMed id 23319000)1 Luykx J.J....Ophoff R.A. (2013)
    7. Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. (PubMed id 21706054)1 Mura M....Bicknell R. (2012)
    8. Clec14a is specifically expressed in endothelial cell s and mediates cell to cell adhesion. (PubMed id 21095181)1 Rho S.S....Kwon Y.G. (2011)
    9. Shear stress, tip cells and regulators of endothelial migration. (PubMed id 22103489)1 Zhuang X....Bicknell R. (2011)
    10. A novel genetic marker for coronary spasm in women from a genome-wide single nucleotide polymorphism analysis. (PubMed id 18075462)4 Suzuki S....Ogawa H. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 161198 HGNC: 19832 AceView: C14orf27 Ensembl:ENSG00000176435 euGenes: HUgn161198
    ECgene: CLEC14A H-InvDB: CLEC14A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLEC14A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLEC14A gene:
    Search GeneIP for patents involving CLEC14A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CLEC14A
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
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     Antibodies for CLEC14A (CLEC14A)   Browse Cell Culture Products  
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     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
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     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CLEC14A  
     OriGene qPCR primer pairs and template standards for CLEC14A   OriGene Protein Over-expression Lysate for CLEC14A  
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     OriGene qSTAR qPCR primer pairs in human, mouse for CLEC14A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CLEC14A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLEC14A   OriGene Custom Protein Services for CLEC14A  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLEC14A
     QIAGEN SeqTarget long-range PCR primers for resequencing CLEC14A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC14A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC14A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC14A
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     GenScript Custom Purified and Recombinant Proteins Services for CLEC14A GenScript cDNA clones with any tag delivered in your preferred vector for CLEC14A
     GenScript Custom Assay Services for CLEC14A GenScript Custom Superior Antibodies Services for CLEC14A
     GenScript Custom overexpressing Cell Line Services for CLEC14A CloneReady with Over 120,000 Genes
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     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
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     Search for Antibodies & Assays

     Regulatory tfbs in CLEC14A promoter
     Search Chromatin IP Primers for CLEC14A
     RT2 qPCR Primer Assay in human, mouse, rat CLEC14A
     Search GNC Networks for CLEC14A
     SABiosciences Custom PCR Arrays for CLEC14A
     Search Tocris compounds for CLEC14A (CLC14)
     Proteins and Antibodies for CLEC14A
     Cell Lysates for CLEC14A
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     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CLEC14A antibodies
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     Antibodies for CLEC14A
     See all of Abcam's Antibodies, Kits and Proteins for CLEC14A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CLEC14A
     Antibodies for CLEC14A
     ELISAs for CLEC14A
     CLIAs for CLEC14A
     Search LifeMap BioReagents cell lines for CLEC14A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC14A
     SwitchGear 3'UTR luciferase reporter plasmids for CLEC14A
     Browse SwitchGear Promoter luciferase reporter plasmids for CLEC14A
     ThermoFisher Antibodies for CLEC14A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC14A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CLEC14A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLEC14A
    Customized:
     lentivirus for stable overexpression of CLEC14A
     lentivirus expression plasmids for stable overexpression of CLEC14A
     adenovirus for overexpression of CLEC14A
     LSBio Antibodies in human, mouse, rat for CLEC14A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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