CLEC12B Gene
protein-coding GIFtS: 40
GCID: GC12P010125
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C-type lectin domain family 12, member B
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Aliases
for CLEC12B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| C-Type Lectin Domain Family 12, Member B1 2 | | Macrophage Antigen H2 3 | | UNQ57822 | | C-Type Lectin Domain Family 12 Member B2 |
Export aliases for CLEC12B gene to outside databasesPrevious GC identifer: GC12P010055 |
Summaries
for CLEC12B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CL12B_HUMAN, Q2HXU8Function: Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulatessignaling cascades and mediates tyrosine phosphorylation of target MAP kinases
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Genomic Views
for CLEC12B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLEC12B gene promoter:
C/EBPbeta AML1a NRSF form 1 FOXD3 MyoD Pax-2 Pax-2a NRSF form 2 PPAR-gamma1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLEC12B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC12B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.2 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13.2CLEC12B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P010125: view genomic region
(about GC identifiers)
Start:
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10,163,226 bp from pter |
End:
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10,171,399 bp from pter |
Size:
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8,174 bases |
Orientation:
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plus strand |
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Proteins
for CLEC12B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CL12B_HUMAN, Q2HXU8 (See
protein sequence)Recommended Name: C-type lectin domain family 12 member B Size: 276 amino acids; 31616 Da
Subunit: Homodimer. Interacts with PTPN6 and PTPN11
Subcellular location: Cell membrane; Single-pass type II membrane protein
Secondary accessions: Q6UWF2 Q6ZRG0Alternative splicing: 2 isoforms: Q2HXU8-1 Q2HXU8-2 Explore the universe of human proteins at neXtProt for CLEC12B: NX_Q2HXU8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2HXU8
CLEC12B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001123470.1 NP_995324.2
ENSEMBL proteins: ENSP00000439561 ENSP00000379759 ENSP00000344563 ENSP00000444909
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
CLEC12B for ontologies About GeneDecksing
CLEC12B Antibody Products:
Assay Products for CLEC12B: |
Protein
Domains /
Families
for CLEC12B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLEC12B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q2HXU8ProtoNet protein and cluster: Q2HXU8 UniProtKB/Swiss-Prot: CL12B_HUMAN, Q2HXU8Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif(ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2domain of several SH2-containing phosphatasesSimilarity: Contains 1 C-type lectin domain |
Function
for CLEC12B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CL12B_HUMAN, Q2HXU8Function: Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulatessignaling cascades and mediates tyrosine phosphorylation of target MAP kinases
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC12B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC12B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CLEC12B (NM_205852) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLEC12B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC12B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC12B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- | | GO:0030246 | carbohydrate binding |
IEA | -- |
CLEC12B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CLEC12B:
Animal Models:
Mouse knock-out Clec12btm1Lex for CLEC12B
1 MGI phenotypic allele  for Clec12b (no phenotypes)
CLEC12B for phenotypes About GeneDecksing
|
Pathways & Interactions
for CLEC12B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC12B
|
Drugs & Compounds
for CLEC12B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CLEC12B
Search CenterWatch for drugs/clinical trials and news about CLEC12B / CL12B
|
Transcripts
for CLEC12B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLEC12B gene (2 alternative transcripts): NM_001129998.1 NM_205852.2 Unigene Cluster for CLEC12B: C-type lectin domain family 12, member B Hs.127937 [show with all ESTs]Unigene Representative Sequence: NM_2058525 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000544853(uc009zhe.2) ENST00000396502(uc001qwx.2 uc001qwy.2)
ENST00000338896(uc001qwz.2) ENST00000535903(uc001qww.1) ENST00000539155
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC12B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC12B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CLEC12B (NM_205852) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLEC12B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC12B |
Additional cDNA sequence: AK128243.1 AK131027.1 AY358810.1 BC036036.1 BC136805.1 BC136806.1 DQ368812.1 3 DOTS entries: DT.404256 DT.40127156 DT.97788836 24/34 AceView cDNA sequences (see all 34): AI700081 AI206245 BX110001 BC036036 BE500950 BM563861 AI829637 AI203190 AK131027 BU189193 BG484230 AA969299 AI657064 BG482702 AA813740 NM_205852 AK128243 AA758723 AY358810 AI655511 AI122809 BE045925 AI655492 AI655354
GeneLoc Exon Structure
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Expression
for CLEC12B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLEC12B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCTCTGGG
About this image
See CLEC12B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLEC12B
SOURCE GeneReport for Unigene cluster: Hs.127937
UniProtKB/Swiss-Prot: CL12B_HUMAN, Q2HXU8Tissue specificity: Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis
SABiosciences Custom PCR Arrays for CLEC12B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC12B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC12B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC12B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC12B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC12B |
Orthologs
for CLEC12B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CLEC12B gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
-- |
Uncharacterized protein |
26(a) |
1 → many |
1(81611682-81618856) |
ENSEMBL Gene Tree for CLEC12B (if available)
TreeFam Gene Tree for CLEC12B (if available) |
Paralogs
for CLEC12B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLEC12B gene
- CLEC9A2 OLR12 KLRC22 ENSG000002558192 CLEC12A2 KLRC32 CLEC1A2 KLRD12
- KLRK12 KLRC42 CLEC1B2 ENSG000002556412 CLEC7A2 KLRC12
7 SIMAP similar genes for CLEC12B using alignment to 3 protein entries: CL12B_HUMAN (see all proteins):CLEC12A KLRD1 KLRK1 CLEC1A OLR1 CLEC1B
CLEC2B
CLEC12B for paralogs About GeneDecksing
|
Genomic Variants
for CLEC12B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLEC12B (10163226 - 10171399 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CLEC12B
1 Inversion: 59704 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CLEC12B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CLEC12B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLEC12B gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLEC12B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of CLEC12B, an inhibitory receptor on myeloid cells. (PubMed id 17562706)1, 2, 3 Hoffmann S.C....Watzl C. (2007)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for CLEC12B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CLEC12B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLEC12B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLEC12B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLEC12B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CLEC12B gene:
Search GeneIP for patents involving CLEC12B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLEC12B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLEC12B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC12B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC12B | | | OriGene Protein Over-expression Lysate for CLEC12B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLEC12B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC12B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC12B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CLEC12B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLEC12B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC12B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC12B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC12B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC12B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC12B |
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| |  |  |  |  | | | | |
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 | | | CLEC12B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC12B |
|  |  |  | | | | Search ThermoFisher Antibodies for CLEC12B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC12B |
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