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Aliases for CLEC12B Gene

Aliases for CLEC12B Gene

  • C-Type Lectin Domain Family 12 Member B 2 3 5
  • Macrophage Antigen H 3 4
  • Testis Secretory Sperm-Binding Protein Li 205a 3
  • C-Type Lectin Domain Family 12, Member B 2
  • UNQ5782 3

External Ids for CLEC12B Gene

Previous GeneCards Identifiers for CLEC12B Gene

  • GC12P010055
  • GC12P010125

Summaries for CLEC12B Gene

GeneCards Summary for CLEC12B Gene

CLEC12B (C-Type Lectin Domain Family 12 Member B) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC7A.

UniProtKB/Swiss-Prot for CLEC12B Gene

  • Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC12B Gene

Genomics for CLEC12B Gene

Regulatory Elements for CLEC12B Gene

Enhancers for CLEC12B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLEC12B on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC12B Gene

Chromosome:
12
Start:
10,009,047 bp from pter
End:
10,018,800 bp from pter
Size:
9,754 bases
Orientation:
Plus strand

Genomic View for CLEC12B Gene

Genes around CLEC12B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC12B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC12B Gene

Proteins for CLEC12B Gene

  • Protein details for CLEC12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2HXU8-CL12B_HUMAN
    Recommended name:
    C-type lectin domain family 12 member B
    Protein Accession:
    Q2HXU8
    Secondary Accessions:
    • Q6UWF2
    • Q6ZRG0

    Protein attributes for CLEC12B Gene

    Size:
    276 amino acids
    Molecular mass:
    31616 Da
    Quaternary structure:
    • Homodimer. Interacts with PTPN6 and PTPN11.

    Alternative splice isoforms for CLEC12B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC12B Gene

Proteomics data for CLEC12B Gene at MOPED

Post-translational modifications for CLEC12B Gene

  • Glycosylation at Asn 91, Asn 176, and Asn 237
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC12B Gene

No data available for DME Specific Peptides for CLEC12B Gene

Domains & Families for CLEC12B Gene

Gene Families for CLEC12B Gene

Protein Domains for CLEC12B Gene

Suggested Antigen Peptide Sequences for CLEC12B Gene

Graphical View of Domain Structure for InterPro Entry

Q2HXU8

UniProtKB/Swiss-Prot:

CL12B_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC12B: view

Function for CLEC12B Gene

Molecular function for CLEC12B Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
genes like me logo Genes that share phenotypes with CLEC12B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC12B

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC12B Gene

Localization for CLEC12B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC12B Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC12B Gene COMPARTMENTS Subcellular localization image for CLEC12B gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CLEC12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CLEC12B: view

Pathways & Interactions for CLEC12B Gene

SuperPathways for CLEC12B Gene

No Data Available

Interacting Proteins for CLEC12B Gene

Gene Ontology (GO) - Biological Process for CLEC12B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLEC12B Gene

Drugs & Compounds for CLEC12B Gene

No Compound Related Data Available

Transcripts for CLEC12B Gene

Unigene Clusters for CLEC12B Gene

C-type lectin domain family 12, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC12B Gene

No ASD Table

Relevant External Links for CLEC12B Gene

GeneLoc Exon Structure for
CLEC12B
ECgene alternative splicing isoforms for
CLEC12B

Expression for CLEC12B Gene

mRNA expression in normal human tissues for CLEC12B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC12B Gene

This gene is overexpressed in Testis (x18.7) and Whole Blood (x15.0).

Protein differential expression in normal tissues from HIPED for CLEC12B Gene

This gene is overexpressed in Plasma (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC12B Gene



SOURCE GeneReport for Unigene cluster for CLEC12B Gene Hs.127937

mRNA Expression by UniProt/SwissProt for CLEC12B Gene

Q2HXU8-CL12B_HUMAN
Tissue specificity: Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis.
genes like me logo Genes that share expression patterns with CLEC12B: view

Protein tissue co-expression partners for CLEC12B Gene

Primer Products

Orthologs for CLEC12B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC12B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLEC12B 35
  • 85.14 (n)
  • 79.71 (a)
CLEC12B 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC611402 35
  • 85.27 (n)
  • 81.88 (a)
CLEC12B 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec12b 35
  • 75.52 (n)
  • 72 (a)
Clec12b 16
Clec12b 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLEC12B 35
  • 98.54 (n)
  • 98.25 (a)
CLEC12B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clec12b 35
  • 74.67 (n)
  • 69.45 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
Species with no ortholog for CLEC12B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC12B Gene

ENSEMBL:
Gene Tree for CLEC12B (if available)
TreeFam:
Gene Tree for CLEC12B (if available)

Paralogs for CLEC12B Gene

Paralogs for CLEC12B Gene

(7) SIMAP similar genes for CLEC12B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLEC12B: view

Variants for CLEC12B Gene

Sequence variations from dbSNP and Humsavar for CLEC12B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1359082 - 10,010,776(+) AGTGA(A/C)CTACG intron-variant, nc-transcript-variant, reference, missense
rs637790 - 10,014,678(-) CAGTA(C/G/T)ACTGG nc-transcript-variant, reference, missense
rs10845018 -- 10,010,202(+) CTCTC(A/T)CACAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs476474 -- 10,012,870(+) GTGAC(A/G)TTGGG nc-transcript-variant, reference, synonymous-codon
rs488907 -- 10,010,136(-) AATGG(A/G)GCATG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CLEC12B Gene

Variant ID Type Subtype PubMed ID
nsv898755 CNV Loss 21882294
nsv898756 CNV Loss 21882294
esv9698 OTHER Inversion 19470904

Variation tolerance for CLEC12B Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.39; 90.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CLEC12B Gene

Disorders for CLEC12B Gene

Relevant External Links for CLEC12B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC12B

No disorders were found for CLEC12B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC12B Gene

Publications for CLEC12B Gene

  1. Identification of CLEC12B, an inhibitory receptor on myeloid cells. (PMID: 17562706) Hoffmann S.C. … Watzl C. (J. Biol. Chem. 2007) 2 3 4 67
  2. Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy. (PMID: 23834954) Kobayashi D. … Fukuda K. (Mol Pain 2013) 3
  3. Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease. (PMID: 24058526) Bhatnagar P. … Arking D.E. (PLoS ONE 2013) 3
  4. Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis. (PMID: 24091439) Kulkarni Y.M. … Liu J. (Analyst 2013) 3
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3

Products for CLEC12B Gene

Sources for CLEC12B Gene

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