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Aliases for CLEC12A Gene

Aliases for CLEC12A Gene

  • C-Type Lectin Domain Family 12, Member A 2 3
  • Myeloid Inhibitory C-Type Lectin-Like Receptor 2 3 4
  • Dendritic Cell-Associated Lectin 2 2 3 4
  • DCAL-2 3 4
  • CLL-1 3 4
  • CLL1 3 4
  • MICL 3 4
  • C-Type Lectin-Like Molecule-1 3
  • C-Type Lectin-Like Molecule 1 4
  • C-Type Lectin Protein CLL-1 3
  • CD371 3
  • DCAL2 4

External Ids for CLEC12A Gene

Previous GeneCards Identifiers for CLEC12A Gene

  • GC12P010016
  • GC12P010124
  • GC12P010103

Summaries for CLEC12A Gene

Entrez Gene Summary for CLEC12A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011]

GeneCards Summary for CLEC12A Gene

CLEC12A (C-Type Lectin Domain Family 12, Member A) is a Protein Coding gene. Diseases associated with CLEC12A include 3mc syndrome. Among its related pathways are Toll-Like receptor Signaling Pathways. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC7A.

UniProtKB/Swiss-Prot for CLEC12A Gene

  • Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

Gene Wiki entry for CLEC12A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC12A Gene

Genomics for CLEC12A Gene

Regulatory Elements for CLEC12A Gene

Genomic Location for CLEC12A Gene

Chromosome:
12
Start:
9,951,316 bp from pter
End:
9,999,354 bp from pter
Size:
48,039 bases
Orientation:
Plus strand

Genomic View for CLEC12A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC12A Gene

Proteins for CLEC12A Gene

  • Protein details for CLEC12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5QGZ9-CL12A_HUMAN
    Recommended name:
    C-type lectin domain family 12 member A
    Protein Accession:
    Q5QGZ9
    Secondary Accessions:
    • B2RA16
    • Q6P4H1
    • Q6RH77
    • Q6RH78
    • Q8TDQ6

    Protein attributes for CLEC12A Gene

    Size:
    265 amino acids
    Molecular mass:
    30762 Da
    Quaternary structure:
    • Interacts with PTPN6 and PTPN11.

    Alternative splice isoforms for CLEC12A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC12A Gene

Proteomics data for CLEC12A Gene at MOPED

Post-translational modifications for CLEC12A Gene

  • Highly N-glycosylated. Glycosylation varies between cell types.
  • Glycosylation at Asn 90, Asn 98, Asn 108, Asn 115, Asn 175, and Asn 220
  • Modification sites at PhosphoSitePlus

Other Protein References for CLEC12A Gene

Antibody Products

  • R&D Systems Antibodies for CLEC12A (MICL/CLEC12A)

No data available for DME Specific Peptides for CLEC12A Gene

Domains & Families for CLEC12A Gene

Gene Families for CLEC12A Gene

Protein Domains for CLEC12A Gene

Suggested Antigen Peptide Sequences for CLEC12A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5QGZ9

UniProtKB/Swiss-Prot:

CL12A_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC12A: view

Function for CLEC12A Gene

Molecular function for CLEC12A Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
UniProtKB/Swiss-Prot Induction:
Down-regulated in activated leukocytes recruited to a site of inflammation.

Gene Ontology (GO) - Molecular Function for CLEC12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC12A: view
genes like me logo Genes that share phenotypes with CLEC12A: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC12A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC12A Gene

Localization for CLEC12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC12A Gene

Cell membrane; Single-pass type II membrane protein. Note=Ligand binding leads to internalization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC12A Gene COMPARTMENTS Subcellular localization image for CLEC12A gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CLEC12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC12A: view

Pathways & Interactions for CLEC12A Gene

genes like me logo Genes that share pathways with CLEC12A: view

Pathways by source for CLEC12A Gene

Interacting Proteins for CLEC12A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000347916%0d%0a9606.ENSP00000452780%0d%0a
Selected Interacting proteins: ENSP00000347916 for CLEC12A Gene via STRING

Symbol External ID(s) Details
B2M

Gene Ontology (GO) - Biological Process for CLEC12A Gene

None

No data available for SIGNOR curated interactions for CLEC12A Gene

Drugs & Compounds for CLEC12A Gene

(8) Drugs for CLEC12A Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium carbonate Approved Pharma 185
Dexamethasone Approved, Investigational Pharma Agonist 1806
Heparin Approved, Investigational Pharma Antagonist 672,226
Calcium Nutra 0
cysteine Nutra 143

(15) Additional Compounds for CLEC12A Gene - From: NovoSeek

genes like me logo Genes that share compounds with CLEC12A: view

Transcripts for CLEC12A Gene

Unigene Clusters for CLEC12A Gene

C-type lectin domain family 12, member A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC12A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC12A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for CLEC12A Gene

GeneLoc Exon Structure for
CLEC12A
ECgene alternative splicing isoforms for
CLEC12A

Expression for CLEC12A Gene

mRNA expression in normal human tissues for CLEC12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC12A Gene

This gene is overexpressed in Whole Blood (x36.9) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for CLEC12A Gene

This gene is overexpressed in Monocytes (32.6), Peripheral blood mononuclear cells (29.9), and Spleen (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC12A Gene



SOURCE GeneReport for Unigene cluster for CLEC12A Gene Hs.190519

mRNA Expression by UniProt/SwissProt for CLEC12A Gene

Q5QGZ9-CL12A_HUMAN
Tissue specificity: Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
genes like me logo Genes that share expression patterns with CLEC12A: view

Protein tissue co-expression partners for CLEC12A Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CLEC12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC12A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLEC12A 35
  • 71.24 (n)
  • 57.65 (a)
CLEC12A 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC12A 35
  • 73.72 (n)
  • 63.08 (a)
CLEC12A 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec12a 35
  • 67.18 (n)
  • 50.39 (a)
Clec12a 16
Clec12a 36
  • 48 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLEC12A 35
  • 98.79 (n)
  • 96.36 (a)
CLEC12A 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clec12a 35
  • 64.86 (n)
  • 47.88 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
Species with no ortholog for CLEC12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC12A Gene

ENSEMBL:
Gene Tree for CLEC12A (if available)
TreeFam:
Gene Tree for CLEC12A (if available)

Paralogs for CLEC12A Gene

Paralogs for CLEC12A Gene

(5) SIMAP similar genes for CLEC12A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLEC12A: view

Variants for CLEC12A Gene

Sequence variations from dbSNP and Humsavar for CLEC12A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs471463 -- 9,963,071(-) CTAAA(A/T)GACAA intron-variant
rs471521 -- 9,963,048(-) gcaac(A/C/T)ccaca intron-variant
rs476844 -- 9,984,697(+) TGTGT(C/T)AACAT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs477751 -- 9,968,968(-) aatga(C/T)cttca intron-variant
rs478829 -- 9,968,812(-) TATCA(A/G)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC12A Gene

Variant ID Type Subtype PubMed ID
nsv523050 CNV Loss 19592680
nsv898755 CNV Loss 21882294
nsv525593 CNV Loss 19592680

Variation tolerance for CLEC12A Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC12A Gene

HapMap Linkage Disequilibrium report
CLEC12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC12A Gene

Disorders for CLEC12A Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLEC12A Gene - From: DISEASES

Disorder Aliases PubMed IDs
3mc syndrome
  • oculopalatoskeletal syndrome
- elite association

Relevant External Links for CLEC12A

Genetic Association Database (GAD)
CLEC12A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC12A
genes like me logo Genes that share disorders with CLEC12A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLEC12A Gene

Publications for CLEC12A Gene

  1. Dual specificity of langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain. (PMID: 20026605) Tateno H. … Hirabayashi J. (J. Biol. Chem. 2010) 23 67
  2. Worms to the rescue: can worm glycans protect from autoimmune diseases? (PMID: 20101628) Kuijk L.M. … van Die I. (IUBMB Life 2010) 23 67
  3. Trimeric structure of langerin. (PMID: 20181944) Feinberg H. … Weis W.I. (J. Biol. Chem. 2010) 23 67
  4. Applications of synthetic carbohydrates to chemical biology. (PMID: 20227905) Lepenies B. … Seeberger P.H. (Curr Opin Chem Biol 2010) 23 67
  5. Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia. (PMID: 19648166) Zhao X. … Korver W. (Haematologica 2010) 23 67

Products for CLEC12A Gene

Sources for CLEC12A Gene

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