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Aliases for CLEC12A Gene

Aliases for CLEC12A Gene

  • C-Type Lectin Domain Family 12, Member A 2 3
  • MICL 3 4 6
  • Myeloid Inhibitory C-Type Lectin-Like Receptor 3 4
  • Dendritic Cell-Associated Lectin 2 3 4
  • DCAL-2 3 4
  • CLL-1 3 4
  • CLL1 3 4
  • C-Type Lectin Domain Family 12 Member A 3
  • C-Type Lectin-Like Molecule-1 3
  • C-Type Lectin-Like Molecule 1 4
  • C-Type Lectin Protein CLL-1 3
  • DCAL2 4

External Ids for CLEC12A Gene

Summaries for CLEC12A Gene

Entrez Gene Summary for CLEC12A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011]

GeneCards Summary for CLEC12A Gene

CLEC12A (C-Type Lectin Domain Family 12, Member A) is a Protein Coding gene. Among its related pathways are NOD-like Receptor Signaling Pathways. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC7A.

UniProtKB/Swiss-Prot for CLEC12A Gene

  • Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

Gene Wiki entry for CLEC12A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC12A Gene

Genomics for CLEC12A Gene

Genomic Location for CLEC12A Gene

Start:
9,951,316 bp from pter
End:
9,995,694 bp from pter
Size:
44,379 bases
Orientation:
Plus strand

Genomic View for CLEC12A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC12A Gene

Regulatory Elements for CLEC12A Gene

Proteins for CLEC12A Gene

  • Protein details for CLEC12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5QGZ9-CL12A_HUMAN
    Recommended name:
    C-type lectin domain family 12 member A
    Protein Accession:
    Q5QGZ9
    Secondary Accessions:
    • B2RA16
    • Q6P4H1
    • Q6RH77
    • Q6RH78
    • Q8TDQ6

    Protein attributes for CLEC12A Gene

    Size:
    265 amino acids
    Molecular mass:
    30762 Da
    Quaternary structure:
    • Interacts with PTPN6 and PTPN11.

    Alternative splice isoforms for CLEC12A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC12A Gene

Proteomics data for CLEC12A Gene at MOPED

Post-translational modifications for CLEC12A Gene

  • Highly N-glycosylated. Glycosylation varies between cell types.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn90, Asn98, Asn108, Asn115, Asn175, and Asn220

Other Protein References for CLEC12A Gene

No data available for DME Specific Peptides for CLEC12A Gene

Domains for CLEC12A Gene

Gene Families for CLEC12A Gene

HGNC:
  • CLEC :C-type lectin domain containing

Protein Domains for CLEC12A Gene

UniProtKB/Swiss-Prot:

CL12A_HUMAN
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases:
    • Q5QGZ9
  • Contains 1 C-type lectin domain.:
    • Q5QGZ9
genes like me logo Genes that share domains with CLEC12A: view

Function for CLEC12A Gene

Molecular function for CLEC12A Gene

UniProtKB/Swiss-Prot Function: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
UniProtKB/Swiss-Prot Induction: Down-regulated in activated leukocytes recruited to a site of inflammation.

Gene Ontology (GO) - Molecular Function for CLEC12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC12A: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLEC12A Gene

Localization for CLEC12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC12A Gene

Cell membrane; Single-pass type II membrane protein. Note=Ligand binding leads to internalization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC12A Gene COMPARTMENTS Subcellular localization image for CLEC12A gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CLEC12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC12A: view

Pathways for CLEC12A Gene

genes like me logo Genes that share pathways with CLEC12A: view

Pathways by source for CLEC12A Gene

Interacting Proteins for CLEC12A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000347916%0d%0a9606.ENSP00000452780%0d%0a
Selected Interacting proteins: ENSP00000347916 for CLEC12A Gene via STRING

Symbol External ID(s) Details
B2M

Gene Ontology (GO) - Biological Process for CLEC12A Gene

None

Compounds for CLEC12A Gene

(23) Novoseek inferred chemical compound relationships for CLEC12A Gene

Compound -log(P) Hits PubMed IDs
mannose 77.6 28
echicetin 74.2 2
mannan 73.9 4
carbohydrates 62.6 13
convulxin 60.6 4
genes like me logo Genes that share compounds with CLEC12A: view

Transcripts for CLEC12A Gene

Unigene Clusters for CLEC12A Gene

C-type lectin domain family 12, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC12A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for CLEC12A Gene

GeneLoc Exon Structure for
CLEC12A
ECgene alternative splicing isoforms for
CLEC12A

Expression for CLEC12A Gene

mRNA expression in normal human tissues for CLEC12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC12A Gene

This gene is overexpressed in Whole Blood (36.9) and Spleen (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CLEC12A Gene

SOURCE GeneReport for Unigene cluster for CLEC12A Gene Hs.190519

mRNA Expression by UniProt/SwissProt for CLEC12A Gene

Q5QGZ9-CL12A_HUMAN
Tissue specificity: Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
genes like me logo Genes that share expressions with CLEC12A: view

Orthologs for CLEC12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC12A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC12A 36
  • 98.79 (n)
  • 96.36 (a)
CLEC12A 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLEC12A 36
  • 71.24 (n)
  • 57.65 (a)
CLEC12A 37
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC12A 36
  • 73.72 (n)
  • 63.08 (a)
CLEC12A 37
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec12a 36
  • 67.18 (n)
  • 50.39 (a)
Clec12a 16
Clec12a 37
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 31 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Clec12a 36
  • 64.86 (n)
  • 47.88 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 32 (a)
OneToMany
Species with no ortholog for CLEC12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC12A Gene

ENSEMBL:
Gene Tree for CLEC12A (if available)
TreeFam:
Gene Tree for CLEC12A (if available)

Paralogs for CLEC12A Gene

Paralogs for CLEC12A Gene

Selected SIMAP similar genes for CLEC12A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLEC12A: view

Variants for CLEC12A Gene

Sequence variations from dbSNP and Humsavar for CLEC12A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs471463 -- 9,963,071(-) CTAAA(A/T)GACAA intron-variant
rs471521 -- 9,963,048(-) gcaac(A/C/T)ccaca intron-variant
rs476844 -- 9,984,697(+) TGTGT(C/T)AACAT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs477751 -- 9,968,968(-) aatga(C/T)cttca intron-variant, upstream-variant-2KB
rs478829 -- 9,968,812(-) TATCA(A/G)TTTTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLEC12A Gene

Variant ID Type Subtype PubMed ID
nsv523050 CNV Loss 19592680
nsv898755 CNV Loss 21882294
nsv525593 CNV Loss 19592680

Relevant External Links for CLEC12A Gene

HapMap Linkage Disequilibrium report
CLEC12A

Disorders for CLEC12A Gene

(13) Novoseek inferred disease relationships for CLEC12A Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 30.4 11
inflammation 10.3 4
nephropathy iga 8.32 1
tuberculosis 3.36 3
hiv infections 0.888 1

Relevant External Links for CLEC12A

Genetic Association Database (GAD)
CLEC12A
genes like me logo Genes that share disorders with CLEC12A: view

No data available for UniProtKB/Swiss-Prot for CLEC12A Gene

Publications for CLEC12A Gene

  1. C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia. (PMID: 15548716) Bakker A.B.H. … Kruisbeek A.M. (Cancer Res. 2004) 3 4 23
  2. Human MICL (CLEC12A) is differentially glycosylated and is down- regulated following cellular activation. (PMID: 16838277) Marshall A.S.J. … Brown G.D. (Eur. J. Immunol. 2006) 3 4 23
  3. Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. (PMID: 14739280) Marshall A.S.J. … Brown G.D. (J. Biol. Chem. 2004) 3 4 23
  4. The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells. (PMID: 17609428) van Rhenen A. … Jan Schuurhuis G. (Blood 2007) 3 23
  5. Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand. (PMID: 18350551) Pyz E. … Brown G.D. (Eur. J. Immunol. 2008) 3 23

Products for CLEC12A Gene

Sources for CLEC12A Gene

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