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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC12A Gene

protein-coding   GIFtS: 52
GCID: GC12P010124

C-Type Lectin Domain Family 12, Member A

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 12, Member A1 2     C-Type Lectin Domain Family 12 Member A2
MICL2 3 5     C-Type Lectin Protein CLL-12
Dendritic Cell-Associated Lectin 22 3     C-Type Lectin Superfamily2
Myeloid Inhibitory C-Type Lectin-Like Receptor2 3     C-Type Lectin-Like Molecule-12
CLL-12 3     DCAL23
CLL12 3     C-Type Lectin-Like Molecule 13
DCAL-22 3     

External Ids:    HGNC: 317131   Entrez Gene: 1603642   Ensembl: ENSG000001723227   OMIM: 6120885   UniProtKB: Q5QGZ93   

Export aliases for CLEC12A gene to outside databases

Previous GC identifer: GC12P010016


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLEC12A Gene:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this
family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling,
glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a
negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of
this gene have been described, but the full-length nature of some of these variants has not been determined. This
gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on
chromosome 12p13. (provided by RefSeq, May 2011)

GeneCards Summary for CLEC12A Gene: 
CLEC12A (C-type lectin domain family 12, member A) is a protein-coding gene. Diseases associated with CLEC12A include langerhans-cell histiocytosis, and histiocytosis, and among its related super-pathways are Inflammasome Activation Pathways. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is OLR1.

UniProtKB/Swiss-Prot: CL12A_HUMAN, Q5QGZ9
Function: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target
MAP kinases

Gene Wiki entry for CLEC12A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC12A gene promoter:
         PPAR-gamma1   POU2F1   POU2F1a   FOXO4   PPAR-gamma2   CUTL1   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC12A promoter sequence
   Search SABiosciences Chromatin IP Primers for CLEC12A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC12A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.31

CLEC12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC12A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P010124:  view genomic region     (about GC identifiers)

Start:
10,103,915 bp from pter      End:
10,148,293 bp from pter
Size:
44,379 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CL12A_HUMAN, Q5QGZ9 (See protein sequence)
Recommended Name: C-type lectin domain family 12 member A  
Size: 265 amino acids; 30762 Da
Subunit: Interacts with PTPN6 and PTPN11
Subcellular location: Cell membrane; Single-pass type II membrane protein. Note=Ligand binding leads to
internalization
Secondary accessions: B2RA16 Q6P4H1 Q6RH77 Q6RH78 Q8TDQ6
Alternative splicing: 5 isoforms:  Q5QGZ9-2   Q5QGZ9-1   Q5QGZ9-3   Q5QGZ9-4   Q5QGZ9-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CLEC12A: NX_Q5QGZ9

Post-translational modifications:

  • UniProtKB: Highly N-glycosylated. Glycosylation varies between cell types
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5QGZ9

  • CLEC12A Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (3 alternative transcripts): 
    NP_001193939.1  NP_612210.4  NP_963917.2  

    ENSEMBL proteins: 
     ENSP00000347916   ENSP00000379764   ENSP00000302804   ENSP00000405244   ENSP00000345448  

    Human Recombinant Protein Products for CLEC12A: 
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    Sino Biological Recombinant Protein for CLEC12A
    Sino Biological Cell Lysate for CLEC12A 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLEC12A 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    CLEC12A for ontologies           About GeneDecksing



    CLEC12A Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q5QGZ9

    ProtoNet protein and cluster: Q5QGZ9

    UniProtKB/Swiss-Prot: CL12A_HUMAN, Q5QGZ9
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind
    the SH2 domain of several SH2-containing phosphatases
    Similarity: Contains 1 C-type lectin domain


    CLEC12A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CL12A_HUMAN, Q5QGZ9
    Function: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target
    MAP kinases
    Induction: Down-regulated in activated leukocytes recruited to a site of inflammation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding IEA--
         
    CLEC12A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLEC12A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLEC12A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC12A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLEC12A 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidCLEC12A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CLEC12A

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CLEC12A (NM_201623)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC12A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLEC12A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CLEC12A
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC12A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLEC12A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLEC12A (CL12A)

    10/23 Novoseek inferred chemical compound relationships for CLEC12A gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 77.6 31 1898081 (2), 12414893 (1), 15128841 (1), 16920496 (1) (see all 27)
    echicetin 74.2 2 11910180 (1), 15320694 (1)
    mannan 73.9 4 8352755 (1), 9832639 (1), 18482990 (1), 9510205 (1)
    carbohydrates 62.6 13 17698636 (1), 12797442 (1), 15482254 (1), 15816015 (1) (see all 13)
    convulxin 60.6 6 16793699 (1), 16689765 (1), 15320694 (1), 9153205 (1)
    neurocan 58.9 1 14722076 (1)
    n-acetylglucosamine 56.5 6 1996409 (1), 1460414 (1), 9832639 (1), 14638630 (1) (see all 5)
    polysaccharide 54.2 13 16179032 (1), 16237199 (1), 16670103 (1), 16951327 (1) (see all 13)
    galactose 41.3 6 7579799 (1), 16670103 (1), 1279438 (1), 17437137 (1)
    slex 36.7 1 8983065 (1)

    Search CenterWatch for drugs/clinical trials and news about CLEC12A / CL12A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLEC12A gene (4 alternative transcripts): 
    NM_001207010.1  NM_138337.5  NM_201623.3  NM_201625.1  

    Unigene Cluster for CLEC12A:

    C-type lectin domain family 12, member A
    Hs.190519  [show with all ESTs]
    Unigene Representative Sequence: NM_138337
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355690(uc001qwq.3 uc001qwt.3) ENST00000396507 ENST00000304361(uc001qwr.4 uc001qws.4)
    ENST00000434319 ENST00000449959 ENST00000350667 ENST00000543839
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLEC12A
    SwitchGear 3'UTR luciferase reporter plasmidCLEC12A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC12A
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    GenScript: all cDNA clones in your preferred vector (see all 2): CLEC12A (NM_201623)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC12A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC12A
    Sirion Biotech Customized lentivirus for stable overexpression of CLEC12A 
                         Customized lentivirus expression plasmids for stable overexpression of CLEC12A 
    Primer
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    OriGene qPCR primer pairs and template standards for CLEC12A
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC12A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC12A

    Additional mRNA sequence: 

    AF247788.1 AK314001.1 AY426759.1 AY498550.1 AY498551.1 AY547296.1 BC063424.1 BC126289.1 
    BC126291.1 

    5 DOTS entries:

    DT.95365614  DT.429861  DT.95365613  DT.91750100  DT.99960597 

    24/49 AceView cDNA sequences (see all 49):

    BI819084 AI219798 AA889871 BC063424 AI190626 BQ017053 AA884901 AI674587 
    BX643514 AW192137 AY498551 NM_201623 AF247788 AI765451 BC027967 AY498550 
    AI695965 BE328894 BX090589 AW467530 AV717615 AV682780 AW293995 AV763804 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC12A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                -                       -         
    SP2:                                -                                 
    SP3:                                -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for CLEC12A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLEC12A expression in normal human tissues (normalized intensities)      CLEC12A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTATTAC
    CLEC12A Expression
    About this image


    CLEC12A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 6 entries
             Bone Marrow CD33+ Cells   
             monocyte-derived macrophage   
     
     Neural Crest (Gastrulation Derivatives)
             mesenchyme   
     
     Umbilical Cord (Extraembryonic Tissues)
             Cord Blood Monocytes (CD14+)   
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Mesoderm (Gastrulation Derivatives)
             mesenchyme   

    Genevestigator expression for CLEC12A

    SOURCE GeneReport for Unigene cluster: Hs.190519

    UniProtKB/Swiss-Prot: CL12A_HUMAN, Q5QGZ9
    Tissue specificity: Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils,
    eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at
    protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear
    leukocytes and macrophages

        SABiosciences Custom PCR Arrays for CLEC12A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC12A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CLEC12A gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec12a1 , 5 C-type lectin domain family 12, member a1, 5 67.44(n)1
    50.58(a)1
      6 (63.26 cM)5
    2324131  NM_177686.41  NP_808354.11 
     1293426915 


    ENSEMBL Gene Tree for CLEC12A (if available)
    TreeFam Gene Tree for CLEC12A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLEC12A gene
    OLR12  CLEC9A2  CLEC1B2  CLEC7A2  CLEC12B2  CLEC1A2  
    5 SIMAP similar genes for CLEC12A using alignment to 3 protein entries:     CL12A_HUMAN (see all proteins):
    KLRD1    KLRK1    CLEC12B    CLEC1A    CLEC2B

    CLEC12A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/935 SNPs in CLEC12A are shown (see all 935)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs740654161,2
    C,F--10101987(+) CTACCC/GAGATG 1 -- us2k12Minor allele frequency- G:0.15WA 120
    rs1834653751,2
    --10102153(+) TGAGGA/GCTGTG 1 -- us2k10--------
    rs740654171,2
    C,F--10102201(+) TGTTTC/TCTGTT 1 -- us2k12Minor allele frequency- T:0.25WA 120
    rs79777611,2
    C,H--10102232(+) AGAACC/TTTAAG 1 -- us2k17Minor allele frequency- T:0.01NS EA NA WA 534
    rs1893574341,2
    --10102338(+) ATTAAA/CCATTT 1 -- us2k10--------
    rs118357451,2
    C,F,H--10102395(+) TAAACC/TTTTAA 1 -- us2k113Minor allele frequency- T:0.08NS EA NA WA 1302
    rs73020841,2
    C,F,H--10102441(+) TAGCAT/CTGGAT 1 -- us2k124Minor allele frequency- C:0.08NS EA NA 2748
    rs749842681,2
    C,F--10102501(+) TAGATA/TAAAAA 1 -- us2k12Minor allele frequency- T:0.03NA EA 240
    rs1820070651,2
    --10102502(+) AGATAA/TAAAAA 1 -- us2k10--------
    rs1871674041,2
    --10102546(+) AGCCAA/CCTTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLEC12A (10103915 - 10148293 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CLEC12A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898755CNV Loss21882294
    nsv523050CNV Loss19592680
    nsv525593CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612088    OMIM disorders: --

    20 diseases for CLEC12A:    About MalaCards
    langerhans-cell histiocytosis    histiocytosis    skeletal dysplasias    idiopathic pulmonary fibrosis
    polycystic kidney disease    pulmonary fibrosis    kidney disease    tuberculosis
    hepatitis c    acute myeloid leukemia    sarcoidosis    lupus erythematosus
    hepatocellular carcinoma    myeloid leukemia    systemic lupus erythematosus    hepatitis
    arthritis    leukemia    pancreatitis    endotheliitis


    CLEC12A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/13 Novoseek inferred disease relationships for CLEC12A gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 30.4 11 1518869 (1), 12477827 (1), 14970226 (1), 11413340 (1) (see all 11)
    inflammation 10.3 4 16838277 (2), 19349622 (1), 9298691 (1)
    nephropathy iga 8.32 1 11721160 (1)
    tuberculosis 3.36 3 16849491 (1), 19318518 (1), 20450644 (1)
    hiv infections 0.888 1 17522223 (1)
    lupus erythematosus systemic 0 1 15352424 (1)
    necrosis 0 2 15140050 (1), 19439262 (1)
    aids 0 1 17317661 (1)
    arthritis 0 2 15368084 (1), 17665455 (1)
    hepatocellular carcinoma 0 3 15373827 (2), 8997243 (1)

    Genetic Association Database (GAD): CLEC12A

    Export disorders for CLEC12A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLEC12A gene, integrated from 9 sources (see all 365):
    (articles sorted by number of sources associating them with CLEC12A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human MICL (CLEC12A) is differentially glycosylated and is down- regulated following cellular activation. (PubMed id 16838277)1, 2, 9 Marshall A.S.J.... Brown G.D. (2006)
    2. C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia. (PubMed id 15548716)1, 2, 9 Bakker A.B.H....Kruisbeek A.M. (2004)
    3. Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. (PubMed id 14739280)1, 2, 9 Marshall A.S.J....Brown G.D. (2004)
    4. Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic- cell maturation and cytokine production. (PubMed id 16239426)1, 2 Chen C.H....Clark E.A. (2006)
    5. Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand. (PubMed id 18350551)1, 9 Pyz E....Brown G.D. (2008)
    6. The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells. (PubMed id 17609428)1, 9 van Rhenen A....Jan Schuurhuis G. (2007)
    7. A genetic association study of the CLEC12A gene in rhe umatoid arthritis. (PubMed id 22341585)1 Michou L....Fernandes M.J. (2012)
    8. Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotyp e. (PubMed id 21677141)1 Lahoud M.H....Caminschi I. (2011)
    9. The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of a ntibody responses. (PubMed id 19494282)1 Lahoud M.H....Caminschi I. (2009)
    10. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 160364 HGNC: 31713 AceView: MICL Ensembl:ENSG00000172322 euGenes: HUgn160364
    ECgene: CLEC12A H-InvDB: CLEC12A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLEC12A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLEC12A gene:
    Search GeneIP for patents involving CLEC12A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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