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CLEC12A Gene

protein-coding   GIFtS: 53
GCID: GC12P010103

C-Type Lectin Domain Family 12, Member A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
C-Type Lectin Domain Family 12, Member A1 2     C-Type Lectin Domain Family 12 Member A2
MICL2 3 5     C-Type Lectin Protein CLL-12
Dendritic Cell-Associated Lectin 22 3     C-Type Lectin Superfamily2
Myeloid Inhibitory C-Type Lectin-Like Receptor2 3     C-Type Lectin-Like Molecule-12
CLL-12 3     DCAL23
CLL12 3     C-Type Lectin-Like Molecule 13
DCAL-22 3     

External Ids:    HGNC: 317131   Entrez Gene: 1603642   Ensembl: ENSG000001723227   OMIM: 6120885   UniProtKB: Q5QGZ93   
ORGUL members:         

Export aliases for CLEC12A gene to outside databases

Previous GC identifers: GC12P010016 GC12P010124


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLEC12A Gene:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this
family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling,
glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a
negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of
this gene have been described, but the full-length nature of some of these variants has not been determined. This
gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on
chromosome 12p13. (provided by RefSeq, May 2011)

GeneCards Summary for CLEC12A Gene:
CLEC12A (C-type lectin domain family 12, member A) is a protein-coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is OLR1.

UniProtKB/Swiss-Prot: CL12A_HUMAN, Q5QGZ9
Function: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target
MAP kinases

Gene Wiki entry for CLEC12A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLEC12A gene promoter:
         PPAR-gamma1   POU2F1   POU2F1a   FOXO4   PPAR-gamma2   CUTL1   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC12A promoter sequence
   Search Chromatin IP Primers for CLEC12A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC12A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.31

CLEC12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC12A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P010103:  view genomic region     (about GC identifiers)

Start:
10,103,915 bp from pter      End:
10,148,293 bp from pter
Size:
44,379 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CL12A_HUMAN, Q5QGZ9 (See protein sequence)
Recommended Name: C-type lectin domain family 12 member A  
Size: 265 amino acids; 30762 Da
Subunit: Interacts with PTPN6 and PTPN11
Secondary accessions: B2RA16 Q6P4H1 Q6RH77 Q6RH78 Q8TDQ6
Alternative splicing: 5 isoforms:  Q5QGZ9-2   Q5QGZ9-1   Q5QGZ9-3   Q5QGZ9-4   Q5QGZ9-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CLEC12A: NX_Q5QGZ9

Post-translational modifications: 

  • Highly N-glycosylated. Glycosylation varies between cell types1
  • Glycosylation2 at Asn90, Asn98, Asn108, Asn115, Asn175, Asn220
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins (3 alternative transcripts): 
    NP_001193939.1  NP_612210.4  NP_963917.2  

    ENSEMBL proteins: 
     ENSP00000347916   ENSP00000379764   ENSP00000302804   ENSP00000405244   ENSP00000345448  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q5QGZ9

    ProtoNet protein and cluster: Q5QGZ9

    UniProtKB/Swiss-Prot: CL12A_HUMAN, Q5QGZ9
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind
    the SH2 domain of several SH2-containing phosphatases
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with CLEC12A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CL12A_HUMAN, Q5QGZ9
    Function: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target
    MAP kinases
    Induction: Down-regulated in activated leukocytes recruited to a site of inflammation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with CLEC12A           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLEC12A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC12A
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CL12A_HUMAN, Q5QGZ9: Cell membrane; Single-pass type II membrane protein. Note=Ligand binding leads to
    internalization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CLEC12A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLEC12A About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CLEC12A
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLEC12A
    Interactions:

        Search GeneGlobe Interaction Network for CLEC12A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLEC12A (CL12A)

    Selected Novoseek inferred chemical compound relationships for CLEC12A gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 77.6 31 1898081 (2), 12414893 (1), 15128841 (1), 16920496 (1) (see all 27)
    echicetin 74.2 2 11910180 (1), 15320694 (1)
    mannan 73.9 4 8352755 (1), 9832639 (1), 18482990 (1), 9510205 (1)
    carbohydrates 62.6 13 17698636 (1), 12797442 (1), 15482254 (1), 15816015 (1) (see all 13)
    convulxin 60.6 6 16793699 (1), 16689765 (1), 15320694 (1), 9153205 (1)
    neurocan 58.9 1 14722076 (1)
    n-acetylglucosamine 56.5 6 1996409 (1), 1460414 (1), 9832639 (1), 14638630 (1) (see all 5)
    polysaccharide 54.2 13 16179032 (1), 16237199 (1), 16670103 (1), 16951327 (1) (see all 13)
    galactose 41.3 6 7579799 (1), 16670103 (1), 1279438 (1), 17437137 (1)
    slex 36.7 1 8983065 (1)



    Find genes that share compounds with CLEC12A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLEC12A gene (4 alternative transcripts): 
    NM_001207010.1  NM_138337.5  NM_201623.3  NM_201625.1  

    Unigene Cluster for CLEC12A:

    C-type lectin domain family 12, member A
    Hs.190519  [show with all ESTs]
    Unigene Representative Sequence: NM_138337
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355690(uc001qwq.3 uc001qwt.3) ENST00000396507 ENST00000304361(uc001qwr.4 uc001qws.4)
    ENST00000434319 ENST00000449959 ENST00000350667 ENST00000543839
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      QuantiFast Probe-based Assays in human, mouse, rat CLEC12A

    Additional mRNA sequence: 

    AF247788.1 AK314001.1 AY426759.1 AY498550.1 AY498551.1 AY547296.1 BC063424.1 BC126289.1 
    BC126291.1 

    5 DOTS entries:

    DT.95365614  DT.429861  DT.95365613  DT.91750100  DT.99960597 

    Selected AceView cDNA sequences (see all 49):

    BI819084 BC063424 AA889871 AI190626 AI219798 AY498551 AW467530 NM_201625 
    AI674587 BX090589 AI954636 NM_138337 AV682780 AW006869 AF247788 AI420431 
    AI765451 AI695965 BQ004793 CD642076 AW192137 AY498552 AV763804 NM_201623 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC12A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                -                       -         
    SP2:                                -                                 
    SP3:                                -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for CLEC12A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLEC12A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTATTAC
    CLEC12A Expression
    About this image


    CLEC12A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CLEC12A Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.190519

    UniProtKB/Swiss-Prot: CL12A_HUMAN, Q5QGZ9
    Tissue specificity: Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils,
    eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at
    protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear
    leukocytes and macrophages

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC12A gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec12a1 , 5 C-type lectin domain family 12, member a1, 5 67.18(n)1
    50.39(a)1
      6 (63.26 cM)5
    2324131  NM_177686.41  NP_808354.11 
     1293426915 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    1 → many
    2(81818136-81823316)


    ENSEMBL Gene Tree for CLEC12A (if available)
    TreeFam Gene Tree for CLEC12A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLEC12A gene
    OLR12  CLEC9A2  CLEC1B2  CLEC7A2  CLEC12B2  CLEC1A2  
    5 SIMAP similar genes for CLEC12A using alignment to 3 protein entries:     CL12A_HUMAN (see all proteins):
    KLRD1    KLRK1    CLEC12B    CLEC1A    CLEC2B

    Find genes that share paralogs with CLEC12A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLEC12A (see all 935)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs740654161,2
    C,F--10101987(+) CTACCC/GAGATG 1 -- us2k12Minor allele frequency- G:0.15WA 120
    rs1834653751,2
    --10102153(+) TGAGGA/GCTGTG 1 -- us2k10--------
    rs740654171,2
    C,F--10102201(+) TGTTTC/TCTGTT 1 -- us2k12Minor allele frequency- T:0.25WA 120
    rs79777611,2
    C,H--10102232(+) AGAACC/TTTAAG 1 -- us2k17Minor allele frequency- T:0.01NS EA NA WA 534
    rs1893574341,2
    --10102338(+) ATTAAA/CCATTT 1 -- us2k10--------
    rs118357451,2
    C,F,H--10102395(+) TAAACC/TTTTAA 1 -- us2k113Minor allele frequency- T:0.08NS EA NA WA 1302
    rs73020841,2
    C,F,H--10102441(+) TAGCAT/CTGGAT 1 -- us2k124Minor allele frequency- C:0.08NS EA NA 2748
    rs749842681,2
    C,F--10102501(+) TAGATA/TAAAAA 1 -- us2k12Minor allele frequency- T:0.03NA EA 240
    rs1820070651,2
    --10102502(+) AGATAA/TAAAAA 1 -- us2k10--------
    rs1871674041,2
    --10102546(+) AGCCAA/CCTTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLEC12A (10103915 - 10148293 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CLEC12A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898755CNV Loss21882294
    nsv523050CNV Loss19592680
    nsv525593CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLEC12A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612088    OMIM disorders: --


    Find genes that share disorders with CLEC12A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CLEC12A gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 30.4 11 1518869 (1), 12477827 (1), 14970226 (1), 11413340 (1) (see all 11)
    inflammation 10.3 4 16838277 (2), 19349622 (1), 9298691 (1)
    nephropathy iga 8.32 1 11721160 (1)
    tuberculosis 3.36 3 16849491 (1), 19318518 (1), 20450644 (1)
    hiv infections 0.888 1 17522223 (1)
    lupus erythematosus systemic 0 1 15352424 (1)
    necrosis 0 2 15140050 (1), 19439262 (1)
    aids 0 1 17317661 (1)
    arthritis 0 2 15368084 (1), 17665455 (1)
    hepatocellular carcinoma 0 3 15373827 (2), 8997243 (1)

    Genetic Association Database (GAD): CLEC12A

    Export disorders for CLEC12A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLEC12A gene, integrated from 10 sources (see all 366):
    (articles sorted by number of sources associating them with CLEC12A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human MICL (CLEC12A) is differentially glycosylated and is down- regulated following cellular activation. (PubMed id 16838277)1, 2, 9 Marshall A.S.J.... Brown G.D. (Eur. J. Immunol. 2006)
    2. C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia. (PubMed id 15548716)1, 2, 9 Bakker A.B.H....Kruisbeek A.M. (Cancer Res. 2004)
    3. Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. (PubMed id 14739280)1, 2, 9 Marshall A.S.J....Brown G.D. (J. Biol. Chem. 2004)
    4. Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic- cell maturation and cytokine production. (PubMed id 16239426)1, 2 Chen C.-H....Clark E.A. (Blood 2006)
    5. Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand. (PubMed id 18350551)1, 9 Pyz E....Brown G.D. (Eur. J. Immunol. 2008)
    6. The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells. (PubMed id 17609428)1, 9 van Rhenen A....Jan Schuurhuis G. (Blood 2007)
    7. hMICL and CD123 in combination with a CD45/CD34/CD117 backbone - a universal marker combination for the detection of minimal residual disease in acute myeloid leukaemia. (PubMed id 24152218)1 Roug A.S....Hokland P. (Br. J. Haematol. 2014)
    8. A genetic association study of the CLEC12A gene in rheumatoid arthritis. (PubMed id 22341585)1 Michou L....Fernandes M.J. (Joint Bone Spine 2012)
    9. Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype. (PubMed id 21677141)1 Lahoud M.H....Caminschi I. (J. Immunol. 2011)
    10. The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses. (PubMed id 19494282)1 Lahoud M.H....Caminschi I. (J. Immunol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 160364 HGNC: 31713 AceView: MICL Ensembl:ENSG00000172322 euGenes: HUgn160364
    ECgene: CLEC12A H-InvDB: CLEC12A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLEC12A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLEC12A gene:
    Search GeneIP for patents involving CLEC12A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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