Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CLEC12A Gene

protein-coding GIFtS: 47
GCID: GC12P010124

C-type lectin domain family 12, member A

Explore 27 diseases affiliated with
CLEC12A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 12, Member A¹ ²		C-Type Lectin Domain Family 12 Member A²
MICL¹ ² ³ ⁵		C-Type Lectin Protein CLL-1²
CLL-1¹ ² ³		C-Type Lectin Superfamily²
Dendritic Cell-Associated Lectin 2² ³		C-Type Lectin-Like Molecule-1²
Myeloid Inhibitory C-Type Lectin-Like Receptor² ³		DCAL2³
CLL1² ³		C-Type Lectin-Like Molecule 1³
DCAL-2² ³

External Ids:	HGNC: 31713¹	Entrez Gene: 160364²	Ensembl: ENSG00000172322⁷	OMIM: 612088⁵	UniProtKB: Q5QGZ9³

Export aliases for CLEC12A gene to outside databases

Previous GC identifer: GC12P010016

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLEC12A:

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this

family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling,

glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative

regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have

been described, but the full-length nature of some of these variants has not been determined. This gene is closely

linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. (provided

by RefSeq, May 2011)

UniProtKB/Swiss-Prot: CL12A_HUMAN, Q5QGZ9

Function: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP

kinases

Gene Wiki entry for CLEC12A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CLEC12A gene promoter:
PPAR-gamma1 POU2F1 POU2F1a FOXO4 PPAR-gamma2 CUTL1 NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLEC12A promoter sequence

Search SABiosciences Chromatin IP Primers for CLEC12A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC12A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13.31

CLEC12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC12A gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P010124: view genomic region (about GC identifiers)

Start:	10,103,915 bp from pter	End:	10,148,293 bp from pter
Size:	44,379 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CL12A_HUMAN, Q5QGZ9 (See protein sequence)

Recommended Name: C-type lectin domain family 12 member A

Size: 265 amino acids; 30762 Da

Subunit: Interacts with PTPN6 and PTPN11

Subcellular location: Cell membrane; Single-pass type II membrane protein. Note=Ligand binding leads to internalization

Secondary accessions: B2RA16 Q6P4H1 Q6RH77 Q6RH78 Q8TDQ6

Alternative splicing: 5 isoforms: Q5QGZ9-2 Q5QGZ9-1 Q5QGZ9-3 Q5QGZ9-4 Q5QGZ9-5 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CLEC12A: NX_Q5QGZ9

Post-translational modifications:

Highly N-glycosylated. Glycosylation varies between cell types¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5QGZ9

CLEC12A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001193939.1 NP_612210.4 NP_963917.2

ENSEMBL proteins:

ENSP00000347916 ENSP00000379764 ENSP00000302804 ENSP00000405244 ENSP00000345448

Human Recombinant Protein Products for CLEC12A:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): CLEC12A OriGene Custom Protein Services for CLEC12A
	GenScript Custom Purified and Recombinant Proteins Services for CLEC12A
	Novus Biologicals CLEC12A Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CLEC12A

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

CLEC12A for ontologies About GeneDecksing

CLEC12A Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CLEC12A (MICL/CLEC12A)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CLEC12A
	GenScript Custom Superior Antibodies Services for CLEC12A
	Novus Biologicals CLEC12A Antibody
	Abcam antibodies for CLEC12A
	Uscn Antibodies for CLEC12A
	ThermoFisher Antibodies for CLEC12A

Assay Products for CLEC12A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CLEC12A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CLEC12A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CLEC12A for domains About GeneDecksing

3 InterPro domains/families:

IPR016187 C-type_lectin_fold

IPR016186 C-type_lectin-like

IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry Q5QGZ9

ProtoNet protein and cluster: Q5QGZ9

UniProtKB/Swiss-Prot: CL12A_HUMAN, Q5QGZ9

Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif

(ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2

domain of several SH2-containing phosphatases

Similarity: Contains 1 C-type lectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CL12A_HUMAN, Q5QGZ9

Function: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP

kinases

Induction: Down-regulated in activated leukocytes recruited to a site of inflammation

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0030246	carbohydrate binding	IEA	--

CLEC12A for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CLEC12A

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CLEC12A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC12A
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLEC12A
		SwitchGear 3'UTR luciferase reporter plasmid: CLEC12A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC12A (see all 7) OriGene shRNA RFP: CLEC12A OriGene siRNA: CLEC12A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC12A
		Sirion Biotech Custom design and validation of potent shRNA sequences against CLEC12A

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CLEC12A
			Sirion Biotech Customized adenovirus for overexpression of CLEC12A Sirion Biotech Customized adenovirus for potent knockdown of CLEC12A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC12A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC12A (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CLEC12A (NM_201623)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC12A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC12A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CLEC12A
		Search LifeMap BioReagents cell lines for CLEC12A
		Sirion Biotech Customized stable knockdown cell line services for CLEC12A Sirion Biotech Customized inducible knockdown cell line services for CLEC12A Sirion Biotech Customized stable overexpressing cell line services for CLEC12A Sirion Biotech Customized inducible overexpressing cell line services for CLEC12A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC12A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CLEC12A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CLEC12A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLEC12A
10/23 Novoseek chemical compound relationships for CLEC12A gene (see all 23) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mannose	77.6	31	1898081 (2), 12414893 (1), 15128841 (1), 16920496 (1) (see all 27)
echicetin	74.2	2	11910180 (1), 15320694 (1)
mannan	73.9	4	8352755 (1), 9832639 (1), 18482990 (1), 9510205 (1)
carbohydrates	62.6	13	17698636 (1), 12797442 (1), 15482254 (1), 15816015 (1) (see all 13)
convulxin	60.6	6	16793699 (1), 16689765 (1), 15320694 (1), 9153205 (1)
neurocan	58.9	1	14722076 (1)
n-acetylglucosamine	56.5	6	1996409 (1), 1460414 (1), 9832639 (1), 14638630 (1) (see all 5)
polysaccharide	54.2	13	16179032 (1), 16237199 (1), 16670103 (1), 16951327 (1) (see all 13)
galactose	41.3	6	7579799 (1), 16670103 (1), 1279438 (1), 17437137 (1)
slex	36.7	1	8983065 (1)

Search CenterWatch for drugs/clinical trials and news about CLEC12A / CL12A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLEC12A gene (4 alternative transcripts):

NM_001207010.1 NM_138337.5 NM_201623.3 NM_201625.1

Unigene Cluster for CLEC12A:

C-type lectin domain family 12, member A

Hs.190519 [show with all ESTs]

Unigene Representative Sequence: NM_138337

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000355690(uc001qwq.3 uc001qwt.3) ENST00000396507 ENST00000304361(uc001qwr.4 uc001qws.4)

ENST00000434319 ENST00000449959 ENST00000350667 ENST00000543839

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CLEC12A Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC12A
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLEC12A
		SwitchGear 3'UTR luciferase reporter plasmid: CLEC12A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC12A (see all 7) OriGene shRNA RFP: CLEC12A OriGene siRNA: CLEC12A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC12A
		Sirion Biotech Custom design and validation of potent shRNA sequences against CLEC12A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC12A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC12A (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CLEC12A (NM_201623)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC12A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC12A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC12A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CLEC12A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC12A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC12A

Additional cDNA sequence:

AF247788.1 AK314001.1 AY426759.1 AY498550.1 AY498551.1 AY547296.1 BC063424.1 BC126289.1

BC126291.1

5 DOTS entries:

DT.95365614 DT.429861 DT.95365613 DT.91750100 DT.99960597

24/49 AceView cDNA sequences (see all 49):

AI219798 AI190626 BI819084 AA889871 BC063424 NM_201623 AI765451 AV717615

AW192137 BC027967 CD642076 BQ017053 AI420431 AY498552 AV763804 NM_201625

NM_138337 AA946590 AW006869 AY498550 AI695965 BX643514 AI954636 AW467530

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC12A About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8
SP1:											-								-
SP2:											-
SP3:											-
SP4:

ECgene alternative splicing isoforms for CLEC12A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLEC12A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTTATTAC

About this image

CLEC12A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CLEC12A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLEC12A

SOURCE GeneReport for Unigene cluster: Hs.190519

UniProtKB/Swiss-Prot: CL12A_HUMAN, Q5QGZ9

Tissue specificity: Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils,

eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein

level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and

macrophages

SABiosciences Custom PCR Arrays for CLEC12A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC12A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CLEC12A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC12A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC12A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC12A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CLEC12A gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	--	Uncharacterized protein	23(a)	1 → many	1(81611682-81618856)

ENSEMBL Gene Tree for CLEC12A (if available)
TreeFam Gene Tree for CLEC12A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CLEC12A gene

CLEC9A² OLR1² KLRC2² ENSG00000255819² CLEC1A² KLRC3² KLRD1² KLRK1²

KLRC4² CLEC1B² ENSG00000255641² CLEC7A² KLRC1² CLEC12B²

5 SIMAP similar genes for CLEC12A using alignment to 3 protein entries: CL12A_HUMAN (see all proteins):

KLRD1 KLRK1 CLEC12B CLEC1A CLEC2B

CLEC12A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7958109^1,2	C	--	9847655(+)	`tctccC/Gtctcc`	1	--	int¹		0	--	--	--	--
rs71049028^1,2	C	--	9880754(+)	`GATAG-/TTGTGG`	1	--	ut3¹		2		NA CSA	4
rs74065416^1,2	C	--	10101987(+)	`CTACCC/GAGATG`	1	--	us2k¹		2		WA	120
rs183465375^1,2		--	10102153(+)	`TGAGGA/GCTGTG`	1	--	us2k¹		0	--	--	--	--
rs74065417^1,2	C	--	10102201(+)	`TGTTTC/TCTGTT`	1	--	us2k¹		2		WA	120
rs7977761^1,2	C,H	--	10102232(+)	`AGAACC/TTTAAG`	1	--	us2k¹		7		NS EA NA WA	534
rs189357434^1,2		--	10102338(+)	`ATTAAA/CCATTT`	1	--	us2k¹		0	--	--	--	--
rs11835745^1,2	C,F,H	--	10102395(+)	`TAAACC/TTTTAA`	1	--	us2k¹		13		NS EA NA WA	1302
rs7302084^1,2	C,F,H	--	10102441(+)	`TAGCAT/CTGGAT`	1	--	us2k¹		24		NS EA NA	2748
rs74984268^1,2	F	--	10102501(+)	`TAGATA/TAAAAA`	1	--	us2k¹		2		NA EA	240

HapMap Linkage Disequilibrium report for CLEC12A (10103915 - 10148293 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLEC12A: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC12A

DNA2.0 Custom Variant and Variant Library Synthesis for CLEC12A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CLEC12A for disorders           About GeneDecksing

OMIM gene information: 612088    OMIM disorders: --

20/27 diseases for CLEC12A (see all 27):    About MalaCards

langerhans-cell histiocytosis mycobacterial infection lupus erythematosus idiopathic pulmonary fibrosis

semd systemic lupus erythematosus polycystic kidney disease histiocytosis

pulmonary fibrosis hepatitis c acute myeloid leukemia myeloid leukemia

kidney disease hepatocellular carcinoma fibrosis nephropathy

sarcoidosis liver cancer arthritis tuberculosis

10/13 Novoseek disease relationships for CLEC12A gene (see all 13) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	30.4	11	1518869 (1), 12477827 (1), 14970226 (1), 11413340 (1) (see all 11)
inflammation	10.3	4	16838277 (2), 19349622 (1), 9298691 (1)
nephropathy iga	8.32	1	11721160 (1)
tuberculosis	3.36	3	16849491 (1), 19318518 (1), 20450644 (1)
hiv infections	0.888	1	17522223 (1)
lupus erythematosus systemic	0	1	15352424 (1)
necrosis	0	2	15140050 (1), 19439262 (1)
aids	0	1	17317661 (1)
arthritis	0	2	15368084 (1), 17665455 (1)
hepatocellular carcinoma	0	3	15373827 (2), 8997243 (1)

Export disorders for CLEC12A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CLEC12A gene, integrated from 9 sources (see all 363):
(articles sorted by number of sources associating them with CLEC12A)

Utopia: connect your pdf to the dynamic
world of online information

Human MICL (CLEC12A) is differentially glycosylated and is down- regulated following cellular activation. (PubMed id 16838277)^{1, 2, 9} Marshall A.S.J.... Brown G.D. (2006)
C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia. (PubMed id 15548716)^{1, 2, 9} Bakker A.B.H....Kruisbeek A.M. (2004)
Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. (PubMed id 14739280)^{1, 2, 9} Marshall A.S.J....Brown G.D. (2004)
Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic- cell maturation and cytokine production. (PubMed id 16239426)^{1, 2} Chen C.H....Clark E.A. (2006)
Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand. (PubMed id 18350551)^{1, 9} Pyz E....Brown G.D. (2008)
The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells. (PubMed id 17609428)^{1, 9} van Rhenen A....Jan Schuurhuis G. (2007)
Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotyp e. (PubMed id 21677141)¹ Lahoud M.H....Caminschi I. (2011)
The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of a ntibody responses. (PubMed id 19494282)¹ Lahoud M.H....Caminschi I. (2009)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)² Liu T.... Smith R.D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 160364	HGNC: 31713	AceView: MICL	Ensembl:ENSG00000172322	euGenes: HUgn160364
ECgene: CLEC12A	H-InvDB: CLEC12A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CLEC12A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CLEC12A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CLEC12A gene:
Search GeneIP for patents involving CLEC12A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CLEC12A (MICL/CLEC12A)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CLEC12A
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLEC12A		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLEC12A
	OriGene Protein Over-expression Lysate for CLEC12A		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CLEC12A		OriGene 3'-UTR Clone for CLEC12A
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC12A		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLEC12A
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CLEC12A		OriGene Custom Protein Services for CLEC12A
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLEC12A
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLEC12A
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC12A
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC12A
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC12A
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC12A

	GenScript Custom Purified and Recombinant Proteins Services for CLEC12A		GenScript cDNA clones with any tag delivered in your preferred vector for CLEC12A
	GenScript Custom Assay Services for CLEC12A		GenScript Custom Superior Antibodies Services for CLEC12A
	GenScript Custom overexpressing Cell Line Services for CLEC12A		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CLEC12A promoter
	Search Chromatin IP Primers for CLEC12A
	RT² qPCR Primer Assay in human, mouse, rat CLEC12A
	Search GNC Networks for CLEC12A
	SABiosciences Custom PCR Arrays for CLEC12A

Search Tocris compounds for CLEC12A

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CLEC12A antibodies
	CLEC12A lysates

	Antibodies for CLEC12A
	See all of Abcam's Antibodies, Kits and Proteins for CLEC12A
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CLEC12A Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CLEC12A

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC12A

	SwitchGear 3'UTR luciferase reporter plasmids for CLEC12A
	SwitchGear Promoter luciferase reporter plasmids for CLEC12A

ThermoFisher Antibodies for CLEC12A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC12A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CLEC12A

Sirion Biotech Customized:

	stable knockdown cell line services for CLEC12A
	inducible knockdown cell line services for CLEC12A
	design and validation of potent shRNA sequences against CLEC12A
	adenovirus for potent knockdown of CLEC12A
	adenovirus for overexpression of CLEC12A
	stable overexpressing cell line services for CLEC12A
	inducible overexpressing cell line services for CLEC12A

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CLEC12A gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CLEC12A Gene

C-type lectin domain family 12, member A

Aliases
for CLEC12A gene

Summaries
for CLEC12A gene

Genomic Views
for CLEC12A gene

Proteins
for CLEC12A gene

Protein Domains /
Families
for CLEC12A gene

Function
for CLEC12A gene

Pathways & Interactions
for CLEC12A gene

Drugs & Compounds
for CLEC12A gene

Transcripts
for CLEC12A gene

Expression
for CLEC12A gene

Orthologs
for CLEC12A gene

Paralogs
for CLEC12A gene

Genomic Variants
for CLEC12A gene

Disorders / Diseases
for CLEC12A gene

Publications
for CLEC12A gene

External Searches for CLEC12A gene

Genome Databases showing CLEC12A gene

Other Databases showing CLEC12A gene

Specialized Databases showing CLEC12A gene

Intellectual Property
for CLEC12A gene

Products
for CLEC12A gene

View Random Gene

Advanced Search

Export list of displayed genes

CLEC12A Gene

C-type lectin domain family 12, member A

Aliasesfor CLEC12A gene

Summariesfor CLEC12A gene

Genomic Viewsfor CLEC12A gene

Proteinsfor CLEC12A gene

Protein Domains /Familiesfor CLEC12A gene

Functionfor CLEC12A gene

Pathways & Interactionsfor CLEC12A gene

Drugs & Compoundsfor CLEC12A gene

Transcriptsfor CLEC12A gene

Expression for CLEC12A gene

Orthologsfor CLEC12A gene

Paralogsfor CLEC12A gene

Genomic Variantsfor CLEC12A gene

Disorders / Diseasesfor CLEC12A gene

Publicationsfor CLEC12A gene

External Searches for CLEC12A gene

Genome Databases showing CLEC12A gene

Other Databases showing CLEC12A gene

Specialized Databases showing CLEC12A gene

Intellectual Propertyfor CLEC12A gene

Productsfor CLEC12A gene

View Random Gene

Aliases
for CLEC12A gene

Summaries
for CLEC12A gene

Genomic Views
for CLEC12A gene

Proteins
for CLEC12A gene

Protein Domains /
Families
for CLEC12A gene

Function
for CLEC12A gene

Pathways & Interactions
for CLEC12A gene

Drugs & Compounds
for CLEC12A gene

Transcripts
for CLEC12A gene

Expression
for CLEC12A gene

Orthologs
for CLEC12A gene

Paralogs
for CLEC12A gene

Genomic Variants
for CLEC12A gene

Disorders / Diseases
for CLEC12A gene

Publications
for CLEC12A gene

Intellectual Property
for CLEC12A gene

Products
for CLEC12A gene