Aliases for CLEC12A Gene
External Ids for CLEC12A Gene
Previous GeneCards Identifiers for CLEC12A Gene
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011]
GeneCards Summary for CLEC12A Gene
CLEC12A (C-Type Lectin Domain Family 12 Member A) is a Protein Coding gene. Diseases associated with CLEC12A include Leukemia, Acute Myeloid. Among its related pathways are Toll-Like receptor Signaling Pathways and Innate Immune System. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC12B.
UniProtKB/Swiss-Prot for CLEC12A Gene
Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.