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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLEC11A Gene

protein-coding   GIFtS: 55
GCID: GC19P051226

C-Type Lectin Domain Family 11, Member A

(Previous name: stem cell growth factor; lymphocyte secreted C-type lectin)
(Previous symbol: SCGF)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C-Type Lectin Domain Family 11, Member A1 2     C-Type Lectin Superfamily Member 32 3
SCGF1 2 3     P472
Stem Cell Growth Factor; Lymphocyte Secreted C-Type Lectin1 2     C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin,
Superfamily Member 32
Lymphocyte Secreted C-Type Lectin2 3     C-Type Lectin Domain Family 11 Member A2
Stem Cell Growth Factor2 3     Lymphocyte Secreted Long Form Of C-Type Lectin2
CLECSF32 3     p473
LSLCL2 3     

External Ids:    HGNC: 105761   Entrez Gene: 63202   Ensembl: ENSG000001054727   OMIM: 6047135   UniProtKB: Q9Y2403   

Export aliases for CLEC11A gene to outside databases

Previous GC identifers: GC19P055919 GC19P047561


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLEC11A Gene:
This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated
glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice
variant has been described but its biological nature has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLEC11A Gene: 
CLEC11A (C-type lectin domain family 11, member A) is a protein-coding gene. Diseases associated with CLEC11A include chronic granulomatous disease, and acute promyelocytic leukemia. GO annotations related to this gene include carbohydrate binding and growth factor activity. An important paralog of this gene is CLEC3A.

UniProtKB/Swiss-Prot: CLC11_HUMAN, Q9Y240
Function: Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages,
including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines,
including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation

Gene Wiki entry for CLEC11A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC11A gene promoter:
         Max1   AP-1   NRSF form 1   Olf-1   STAT5A   AP-2gamma   NRSF form 2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLEC11A promoter sequence
   Search SABiosciences Chromatin IP Primers for CLEC11A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLEC11A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

CLEC11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC11A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P051226:  view genomic region     (about GC identifiers)

Start:
51,226,586 bp from pter      End:
51,228,981 bp from pter
Size:
2,396 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLC11_HUMAN, Q9Y240 (See protein sequence)
Recommended Name: C-type lectin domain family 11 member A precursor  
Size: 323 amino acids; 35695 Da
Subcellular location: Cytoplasm. Secreted
Developmental stage: In the bone marrow, expression is limited to immature neutrophils. Expression was not
detected in circulating mature neutrophils
Secondary accessions: B2RAD4

Explore the universe of human proteins at neXtProt for CLEC11A: NX_Q9Y240

Explore proteomics data for CLEC11A at MOPED 

Post-translational modifications:

  • UniProtKB: O-glycosylated. Probably sulfated on the O-glycans
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y240

  • CLEC11A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLEC11A Protein Expression
    REFSEQ proteins: NP_002966.1  
    ENSEMBL proteins: 
     ENSP00000250340   ENSP00000471075  

    Human Recombinant Protein Products for CLEC11A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CLEC11A (SCGF/CLEC11a)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CLEC11A
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CLEC11A
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    Novus Biologicals CLEC11A Protein
    Novus Biologicals CLEC11A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLEC11A 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA9442024
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--

    CLEC11A for ontologies           About GeneDecksing



    CLEC11A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for CLEC11A
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    LSBio Antibodies in human, mouse, rat for CLEC11A 

    Assay Products for CLEC11A: 
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    GenScript Custom Assay Services for CLEC11A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLEC11A 
    Cloud-Clone Corp. CLIAs for CLEC11A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLEC: C-type lectin domain containing

    4 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q9Y240

    ProtoNet protein and cluster: Q9Y240

    UniProtKB/Swiss-Prot: CLC11_HUMAN, Q9Y240
    Similarity: Contains 1 C-type lectin domain


    CLEC11A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLC11_HUMAN, Q9Y240
    Function: Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages,
    including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines,
    including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity IDA11920266
    GO:0030246carbohydrate binding NAS9705843
         
    CLEC11A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CLEC11A:
     Elongated cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLEC11A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLEC11A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLEC11A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLEC11A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC11A
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CLEC11A:
    hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidCLEC11A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CLEC11A

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CLEC11A (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLEC11A (NM_002975)
    Sino Biological Human cDNA Clone for CLEC11A
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                         Customized lentivirus expression plasmids for stable overexpression of CLEC11A 

    Cell Line
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    Search LifeMap BioReagents cell lines for CLEC11A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC11A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC11A

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CLEC11A (Q9Y2403 ENSP000002503404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KITLGP215833, ENSP000002282804I2D: score=1 STRING: ENSP00000228280
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation IDA11920266

    CLEC11A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLEC11A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLEC11A (CLC11)

    5 Novoseek inferred chemical compound relationships for CLEC11A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadph 53.9 8 8305497 (2), 18287880 (2), 10544947 (2), 12668498 (1) (see all 5)
    retinoic acid 22.1 2 2317454 (1), 2398896 (1)
    superoxide 20.7 3 8305497 (2)
    vegf 17.1 4 15186719 (2), 10807776 (2)
    calcium 0 1 8305497 (1)

    Search CenterWatch for drugs/clinical trials and news about CLEC11A / CLC11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLEC11A gene: 
    NM_002975.2  

    Unigene Cluster for CLEC11A:

    C-type lectin domain family 11, member A
    Hs.512680  [show with all ESTs]
    Unigene Representative Sequence: NM_002975
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250340(uc002psy.3) ENST00000599973
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLEC11A
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CLEC11A:
    hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidCLEC11A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLEC11A
    Clone
    Products:
         
    OriGene clones in human, mouse for CLEC11A (see all 7)
    OriGene ORF clones in mouse, rat for CLEC11A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLEC11A (NM_002975)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLEC11A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLEC11A
    Sirion Biotech Customized lentivirus for stable overexpression of CLEC11A 
                         Customized lentivirus expression plasmids for stable overexpression of CLEC11A 
    Primer
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    OriGene qPCR primer pairs and template standards for CLEC11A
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLEC11A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLEC11A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC11A

    Additional mRNA sequence: 

    AB009244.1 AF020044.1 AK314141.1 AY870345.1 BC005810.2 BT019673.1 D86586.1 

    4 DOTS entries:

    DT.100038141  DT.92422143  DT.97826467  DT.121495156 

    24/138 AceView cDNA sequences (see all 138):

    CB216706 BM719769 BM694459 CR608691 CF126335 BQ014793 BQ010121 AB009244 
    BQ677972 D86586 CR606484 BU175498 BM694203 BF724772 CF128447 NM_002975 
    BM992387 BU627915 BQ682482 CA418452 BU682494 CA424907 BQ676989 CF128820 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLEC11A expression in normal human tissues (normalized intensities)      CLEC11A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTCGGGG
    CLEC11A Expression
    About this image


    CLEC11A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 4 entries
             PureStem Progenitor W10
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
             bone marrow   
     
     Blood (Muscoskeletal System)
             bone marrow   
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells

    See CLEC11A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLEC11A

    SOURCE GeneReport for Unigene cluster: Hs.512680

    UniProtKB/Swiss-Prot: CLC11_HUMAN, Q9Y240
    Tissue specificity: Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification
    center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen,
    thymus, appendix and fetal liver

        SABiosciences Custom PCR Arrays for CLEC11A
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLEC11A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC11A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLEC11A gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec11a1 , 5 C-type lectin domain family 11, member a1, 5 82.77(n)1
    85.14(a)1
      7 (28.83 cM)5
    202561  NM_009131.31  NP_033157.11 
     443037705 
    lizard
    (Anolis carolinensis)
    Reptilia CLEC11A6
    C-type lectin domain family 11, member A
    43(a)
    1 ↔ 1
    6(79261143-79290869)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5683551 c-type lectin domain family 11 member A-like 53.72(n)
    49.51(a)
      568355  XM_691681.2  XP_696773.2 


    ENSEMBL Gene Tree for CLEC11A (if available)
    TreeFam Gene Tree for CLEC11A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLEC11A gene
    CLEC3A2  CLEC3B2  
    1 SIMAP similar gene for CLEC11A using alignment to 3 protein entries:     CLC11_HUMAN (see all proteins):
    DKFZp686H17246

    CLEC11A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/91 SNPs in CLEC11A are shown (see all 91)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428554121,2
    --51224680(+) AGAGGC/TCCAGG 1 -- us2k10--------
    rs1922428861,2
    --51224728(+) CCCTCG/TATGTA 1 -- us2k10--------
    rs1839577111,2
    --51224852(+) CTGCCC/GCCACA 1 -- us2k10--------
    rs1157669871,2
    F--51225188(+) CTCAAC/TAGGTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1452531111,2
    --51225316(+) GATTAC/TACCAA 1 -- us2k10--------
    rs1120210231,2
    C,F--51225342(+) CATTTG/TAATAA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs118828621,2
    C,F,H--51225367(+) TAGATA/GAGGTG 1 -- us2k18Minor allele frequency- G:0.06NS NA WA 914
    rs1900353551,2
    C--51225404(+) ACCTCA/GATGAT 1 -- us2k10--------
    rs8908631,2
    C,F,H--51225544(-) CCCCAC/TTCCCT 1 -- us2k112Minor allele frequency- T:0.34NA WA CSA EA 373
    rs1422853151,2
    --51225575(+) CAAAGA/GGTTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLEC11A (51226586 - 51228981 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CLEC11A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912287CNV Loss21882294
    nsv828583CNV Loss20364138
    nsv912285CNV Loss21882294


    Human Gene Mutation Database (HGMD): CLEC11A
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLEC11A
    DNA2.0 Custom Variant and Variant Library Synthesis for CLEC11A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604713    OMIM disorders: --

    10 diseases for CLEC11A:    About MalaCards
    chronic granulomatous disease    acute promyelocytic leukemia    piebaldism    osteopetrosis
    vitiligo    anemia    myeloid leukemia    endotheliitis
    leukemia    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CLEC11A:
    Piebaldism

    CLEC11A for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CLEC11A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    granulomatous disease chronic 56.6 1 2317454 (1)

    Genetic Association Database (GAD): CLEC11A
    Human Genome Epidemiology (HuGE) Navigator: CLEC11A (2 documents)

    Export disorders for CLEC11A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLEC11A gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with CLEC11A)
        Utopia: connect your pdf to the dynamic
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    1. Molecular cloning of a new secreted sulfated mucin-like protein with a C-type lectin domain that is expressed in lymphoblastic cells. (PubMed id 9442024)1, 2, 3 Bannwarth S.... Lefebvre J.-C. (1998)
    2. Cloning, expression, and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells. (PubMed id 9207134)1, 3, 9 Hiraoka A....Shimizu S. (1997)
    3. Isolation and characterization of a cDNA for human, mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily. (PubMed id 9705843)1, 2, 9 Mio H.... Hiraoka A. (1998)
    4. Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells. (PubMed id 11920266)1, 2, 9 Hiraoka A....Sugimoto S. (2001)
    5. Association study between keratinocyte-derived growth factor gene polymorphisms and susceptibility to vitiligo vulgaris in a Taiwanese population: potential involvement of stem cell factor. (PubMed id 19416273)1, 4, 9 Lan C.C....Yu H.S. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Expression of LSLCL, a new C-type lectin, is closely restricted, in bone marrow, to immature neutrophils. (PubMed id 11803813)1, 2 Perrin C.... Giordanengo V. (2001)
    8. Cloning, mapping, and genomic organization of the LSLCL gene, encoding a new lymphocytic secreted mucin-like protein with a C-type lectin domain: a new model of exon shuffling. (PubMed id 10198175)1, 2 Bannwarth S....Lefebvre J.-C. (1999)
    9. Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation. (PubMed id 12900775)1, 9 Ito C....Hotta T. (2003)
    10. A novel functional variant in the stem cell growth fa ctor promoter protects against severe malarial anemia. (PubMed id 19884328)1, 9 Ouma C....Perkins D.J. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6320 HGNC: 10576 AceView: SCGF Ensembl:ENSG00000105472 euGenes: HUgn6320
    ECgene: CLEC11A H-InvDB: CLEC11A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLEC11A Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_259

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
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    Patent Information for CLEC11A gene:
    Search GeneIP for patents involving CLEC11A

    GeneCards and IP:
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