Aliases for CLEC11A Gene
External Ids for CLEC11A Gene
Previous HGNC Symbols for CLEC11A Gene
Previous GeneCards Identifiers for CLEC11A Gene
This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLEC11A Gene
CLEC11A (C-Type Lectin Domain Family 11 Member A) is a Protein Coding gene. Diseases associated with CLEC11A include Pneumonic Tularemia and Indolent Systemic Mastocytosis. Among its related pathways are Activation of cAMP-Dependent PKA and GPCR Pathway. GO annotations related to this gene include carbohydrate binding and growth factor activity. An important paralog of this gene is CLEC3A.
UniProtKB/Swiss-Prot for CLEC11A Gene
Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.