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Aliases for CLEC11A Gene

Aliases for CLEC11A Gene

  • C-Type Lectin Domain Family 11, Member A 2 3
  • Stem Cell Growth Factor; Lymphocyte Secreted C-Type Lectin 2 3
  • C-Type Lectin Superfamily Member 3 3 4
  • Lymphocyte Secreted C-Type Lectin 3 4
  • Stem Cell Growth Factor 3 4
  • CLECSF3 3 4
  • LSLCL 3 4
  • SCGF 3 4
  • P47 3 4
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 3 3
  • Lymphocyte Secreted Long Form Of C-Type Lectin 3

External Ids for CLEC11A Gene

Previous HGNC Symbols for CLEC11A Gene

  • SCGF

Previous GeneCards Identifiers for CLEC11A Gene

  • GC19P055919
  • GC19P051226
  • GC19P047561

Summaries for CLEC11A Gene

Entrez Gene Summary for CLEC11A Gene

  • This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLEC11A Gene

CLEC11A (C-Type Lectin Domain Family 11, Member A) is a Protein Coding gene. Diseases associated with CLEC11A include indolent systemic mastocytosis and pneumonic tularemia. Among its related pathways are NF-KappaB Family Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include carbohydrate binding and growth factor activity. An important paralog of this gene is CLEC3A.

UniProtKB/Swiss-Prot for CLEC11A Gene

  • Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.

Gene Wiki entry for CLEC11A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC11A Gene

Genomics for CLEC11A Gene

Regulatory Elements for CLEC11A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLEC11A Gene

Chromosome:
19
Start:
50,723,329 bp from pter
End:
50,725,724 bp from pter
Size:
2,396 bases
Orientation:
Plus strand

Genomic View for CLEC11A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC11A Gene

Proteins for CLEC11A Gene

  • Protein details for CLEC11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y240-CLC11_HUMAN
    Recommended name:
    C-type lectin domain family 11 member A
    Protein Accession:
    Q9Y240
    Secondary Accessions:
    • B2RAD4

    Protein attributes for CLEC11A Gene

    Size:
    323 amino acids
    Molecular mass:
    35695 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC11A Gene

Proteomics data for CLEC11A Gene at MOPED

Post-translational modifications for CLEC11A Gene

Other Protein References for CLEC11A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CLEC11A (SCGF/CLEC11a)

No data available for DME Specific Peptides for CLEC11A Gene

Domains & Families for CLEC11A Gene

Gene Families for CLEC11A Gene

Protein Domains for CLEC11A Gene

Suggested Antigen Peptide Sequences for CLEC11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y240

UniProtKB/Swiss-Prot:

CLC11_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC11A: view

Function for CLEC11A Gene

Molecular function for CLEC11A Gene

UniProtKB/Swiss-Prot Function:
Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.

Gene Ontology (GO) - Molecular Function for CLEC11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IDA 11920266
GO:0030246 carbohydrate binding NAS 9705843
genes like me logo Genes that share ontologies with CLEC11A: view

Phenotypes for CLEC11A Gene

GenomeRNAi human phenotypes for CLEC11A:
genes like me logo Genes that share phenotypes with CLEC11A: view

Animal Model Products

CRISPR Products

miRNA for CLEC11A Gene

miRTarBase miRNAs that target CLEC11A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC11A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC11A Gene

Localization for CLEC11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC11A Gene

Cytoplasm. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC11A Gene COMPARTMENTS Subcellular localization image for CLEC11A gene
Compartment Confidence
extracellular 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for CLEC11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 9442024
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CLEC11A: view

Pathways & Interactions for CLEC11A Gene

genes like me logo Genes that share pathways with CLEC11A: view

Interacting Proteins for CLEC11A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000250340%0d%0a9606.ENSP00000228280%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9Y240-CLC11_HUMAN ENSP00000250340 for CLEC11A Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CLEC11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 11920266
genes like me logo Genes that share ontologies with CLEC11A: view

No data available for SIGNOR curated interactions for CLEC11A Gene

Drugs & Compounds for CLEC11A Gene

(1) Drugs for CLEC11A Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0

(4) Additional Compounds for CLEC11A Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
retinoic acid
302-79-4
superoxide
  • Dioxidanidyl
  • Dioxide(1-)
  • Hyperoxid
  • Superoxide
  • Superoxide anion
11062-77-4
VEGF
genes like me logo Genes that share compounds with CLEC11A: view

Transcripts for CLEC11A Gene

mRNA/cDNA for CLEC11A Gene

Unigene Clusters for CLEC11A Gene

C-type lectin domain family 11, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC11A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC11A Gene

No ASD Table

Relevant External Links for CLEC11A Gene

GeneLoc Exon Structure for
CLEC11A
ECgene alternative splicing isoforms for
CLEC11A

Expression for CLEC11A Gene

mRNA expression in normal human tissues for CLEC11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLEC11A Gene

This gene is overexpressed in Serum (25.0), Breast (15.4), Bone marrow mesenchymal stem cell (12.7), and Pancreas (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLEC11A Gene



SOURCE GeneReport for Unigene cluster for CLEC11A Gene Hs.512680

mRNA Expression by UniProt/SwissProt for CLEC11A Gene

Q9Y240-CLC11_HUMAN
Tissue specificity: Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.
genes like me logo Genes that share expression patterns with CLEC11A: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CLEC11A Gene

Orthologs for CLEC11A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC11A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLEC11A 35
  • 86.27 (n)
  • 85.76 (a)
CLEC11A 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC11A 35
  • 88.44 (n)
  • 90.4 (a)
CLEC11A 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec11a 35
  • 82.77 (n)
  • 85.14 (a)
Clec11a 16
Clec11a 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLEC11A 35
  • 99.28 (n)
  • 99.69 (a)
CLEC11A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clec11a 35
  • 81.42 (n)
  • 83.28 (a)
oppossum
(Monodelphis domestica)
Mammalia CLEC11A 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLEC11A 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLEC11A 36
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CU929133.1 36
  • 37 (a)
OneToOne
Species with no ortholog for CLEC11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLEC11A Gene

ENSEMBL:
Gene Tree for CLEC11A (if available)
TreeFam:
Gene Tree for CLEC11A (if available)

Paralogs for CLEC11A Gene

Paralogs for CLEC11A Gene

(1) SIMAP similar genes for CLEC11A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CLEC11A: view

Variants for CLEC11A Gene

Sequence variations from dbSNP and Humsavar for CLEC11A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs13866 -- 50,725,489(+) CCTCC(C/T)TGCCC utr-variant-3-prime
rs890863 -- 50,722,287(-) CCCCA(C/T)TCCCT upstream-variant-2KB
rs1053020 -- 50,725,545(+) GAATC(G/T)CCCTT utr-variant-3-prime
rs1053022 -- 50,725,556(+) CCCTT(C/T)CTGGC utr-variant-3-prime
rs2303688 - 50,724,068(-) CCTCA(C/G)GGGTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CLEC11A Gene

Variant ID Type Subtype PubMed ID
nsv828583 CNV Loss 20364138
nsv912285 CNV Loss 21882294
nsv912287 CNV Loss 21882294

Variation tolerance for CLEC11A Gene

Residual Variation Intolerance Score: 74.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC11A Gene

HapMap Linkage Disequilibrium report
CLEC11A
Human Gene Mutation Database (HGMD)
CLEC11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC11A Gene

Disorders for CLEC11A Gene

MalaCards: The human disease database

(4) MalaCards diseases for CLEC11A Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
indolent systemic mastocytosis
  • ism
pneumonic tularemia
  • pneumonic tularaemia
chronic granulomatous disease
  • quie syndrome
piebaldism
  • piebald trait
- elite association

Relevant External Links for CLEC11A

Genetic Association Database (GAD)
CLEC11A
Human Genome Epidemiology (HuGE) Navigator
CLEC11A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC11A
genes like me logo Genes that share disorders with CLEC11A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLEC11A Gene

Publications for CLEC11A Gene

  1. Cloning, expression, and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells. (PMID: 9207134) Hiraoka A. … Shimizu S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 23 67
  2. A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia. (PMID: 19884328) Ouma C. … Perkins D.J. (Infect. Immun. 2010) 23 67
  3. Identification and quantification of proteins differentially secreted by a pair of normal and malignant breast-cancer cell lines. (PMID: 19053080) Liang X. … Pope R.M. (Proteomics 2009) 23 67
  4. Cytoplasmic proteome and secretome profiles of differently stimulated human dendritic cells. (PMID: 19351150) Gundacker N.C. … Gerner C. (J. Proteome Res. 2009) 23 67
  5. Association study between keratinocyte-derived growth factor gene polymorphisms and susceptibility to vitiligo vulgaris in a Taiwanese population: potential involvement of stem cell factor. (PMID: 19416273) Lan C.C. … Yu H.S. (Br. J. Dermatol. 2009) 23 67

Products for CLEC11A Gene

Sources for CLEC11A Gene

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