Aliases for CLEC11A Gene
External Ids for CLEC11A Gene
Previous HGNC Symbols for CLEC11A Gene
Previous GeneCards Identifiers for CLEC11A Gene
This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLEC11A Gene
CLEC11A (C-Type Lectin Domain Family 11, Member A) is a Protein Coding gene. Diseases associated with CLEC11A include indolent systemic mastocytosis and pneumonic tularemia. Among its related pathways are NF-KappaB Family Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include carbohydrate binding and growth factor activity. An important paralog of this gene is CLEC3A.
UniProtKB/Swiss-Prot for CLEC11A Gene
Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.