Aliases for CLEC10A Gene
Aliases for CLEC10A Gene
- C-Type Lectin Domain Family 10 Member A 2 3 5
- C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 14 (Macrophage-Derived) 2 3
- C-Type Lectin Domain Family 10, Member A 2 3
- Macrophage Lectin 2 (Calcium Dependent) 2 3
- CLECSF13 3 4
- CLECSF14 3 4
- HML 3 4
- C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 13 (Macrophage-Derived) 3
External Ids for CLEC10A Gene
- HGNC: 16916
- Entrez Gene: 10462
- Ensembl: ENSG00000132514
- OMIM: 605999
- UniProtKB: Q8IUN9
Previous HGNC Symbols for CLEC10A Gene
- CLECSF13
- CLECSF14
Previous GeneCards Identifiers for CLEC10A Gene
- GC17M006919
- GC17M006923
- GC17M006977
- GC17M006871
Summaries for CLEC10A Gene
-
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLEC10A Gene
CLEC10A (C-Type Lectin Domain Family 10 Member A) is a Protein Coding gene. Diseases associated with CLEC10A include Lown-Ganong-Levine Syndrome and Partial Optic Atrophy. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC6A.
UniProtKB/Swiss-Prot for CLEC10A Gene
-
Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC10A Gene
Genomics for CLEC10A Gene
Regulatory Elements for CLEC10A Gene
Enhancers for CLEC10A Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around CLEC10A on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CLEC10A gene promoter:
Regulatory Element Products
Genomic Location for CLEC10A Gene
- Chromosome:
- 17
- Start:
- 7,074,537 bp from pter
- End:
- 7,080,601 bp from pter
- Size:
- 6,065 bases
- Orientation:
- Minus strand
Genomic View for CLEC10A Gene
Genes around CLEC10A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by Ensembl
- 17p13.1 by Entrez Gene
- 17p13.2 by HGNC
CLEC10A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CLEC10A Gene
Proteins for CLEC10A Gene
-
Protein details for CLEC10A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IUN9-CLC10_HUMAN
- Recommended name:
- C-type lectin domain family 10 member A
- Protein Accession:
- Q8IUN9
- A8K8J8
- Q14538
- Q6PIW3
Protein attributes for CLEC10A Gene
- Size:
- 316 amino acids
- Molecular mass:
- 35446 Da
- Quaternary structure:
- No Data Available
Protein Expression for CLEC10A Gene
Post-translational modifications for CLEC10A Gene
Other Protein References for CLEC10A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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-
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-
Santa Cruz Biotechnology (SCBT) Antibodies for CLEC10A
Protein Products
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-
Cloud-Clone Corp. Proteins for CLEC10A
- antibodies-online Proteins for CLEC10A: See all 22
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Assay Products
- antibodies-online Kits for CLEC10A: See all 9
No data available for DME Specific Peptides for CLEC10A Gene
Domains & Families for CLEC10A Gene
Gene Families for CLEC10A Gene
Protein Domains for CLEC10A Gene
Suggested Antigen Peptide Sequences for CLEC10A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IUN9- Domain:
-
- Contains 1 C-type lectin domain.
Function for CLEC10A Gene
Molecular function for CLEC10A Gene
- UniProtKB/Swiss-Prot Function:
- Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.
Phenotypes for CLEC10A Gene
- MGI mutant phenotypes for CLEC10A:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CLEC10A:
Animal Models for CLEC10A Gene
- MGI Knock Outs for CLEC10A:
-
- Mgl2 tm1.1(HBEGF/EGFP)Aiwsk
Animal Model Products
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-
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CRISPR Products
-
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-
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miRNA Products
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Clone Products
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Cell Line Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC10A Gene
Localization for CLEC10A Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLEC10A Gene
- Membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| chloroplast | 2 |
| cytosol | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | 8598452 |
Pathways & Interactions for CLEC10A Gene
More details on SuperPathways for CLEC10A
No Data Available
Interacting Proteins for CLEC10A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0045087 | innate immune response | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CLEC10A Gene
Drugs & Compounds for CLEC10A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CLEC10A Gene
mRNA/cDNA for CLEC10A Gene
- (6) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (51) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CLEC10A Gene
CRISPR Products
-
OriGene CRISPR knockouts for CLEC10A
-
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miRNA Products
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Clone Products
- OriGene clones in human for CLEC10A
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||
| SP6: |
Expression for CLEC10A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CLEC10A Gene
This gene is overexpressed in Whole Blood (x5.5).
This gene is overexpressed in Heart (61.9) and Fetal Liver (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC10A Gene
SOURCE GeneReport for Unigene cluster for CLEC10A Gene Hs.54403
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for CLEC10A
No data available for mRNA Expression by UniProt/SwissProt for CLEC10A Gene
Orthologs for CLEC10A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | CLEC10A 35 |
|
||
| CLEC10A 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | CLEC10A 35 |
|
||
| -- 36 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Mgl2 35 |
|
||
| Mgl2 16 |
|
||||
| Clec10a 36 |
|
OneToMany | |||
| Mgl2 36 |
|
OneToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | CLEC10A 35 |
|
||
| CLEC10A 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Clec10a 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | clec10a 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101882127 35 |
|
||
| si:ch211-283g2.2 36 |
|
ManyToMany | |||
| si:ch211-283g2.3 36 |
|
ManyToMany | |||
| si:ch73-361h17.1 36 |
|
ManyToMany |
- Species with no ortholog for CLEC10A:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CLEC10A Gene
Paralogs for CLEC10A Gene
(18) SIMAP similar genes for CLEC10A Gene using alignment to 4 proteins:
Variants for CLEC10A Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs90951 | - | 7,078,078(+) | AGAGC(A/G)GAGAC | reference, missense | |
| rs16956478 | - | 7,076,954(+) | CTGTT(C/T)TCAGG | reference, missense | |
| rs35318160 | - | 7,076,786(-) | AGAAA(C/T)GATAG | reference, missense | |
| rs35101468 | - | 7,075,798(-) | CTGGG(C/G)CGAGG | reference, missense | |
| rs15623 | -- | 7,075,000(-) | GACTC(C/T)TCTCA | utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2422288 | CNV | Deletion | 17116639 |
| nsv457659 | CNV | Loss | 19166990 |
| esv2669929 | CNV | Deletion | 23128226 |
| nsv907635 | CNV | Loss | 21882294 |
| esv5167 | CNV | Deletion | 18987735 |
| esv2657406 | CNV | Deletion | 23128226 |
Residual Variation Intolerance Score:
95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.86;
58.86% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CLEC10A Gene
Disorders for CLEC10A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lown-ganong-levine syndrome |
|
|
| partial optic atrophy |
|
|
| methylmalonic aciduria and homocystinuria, cblc type |
|
|
| mesenteric lymphadenitis |
|
|
Search CLEC10A in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CLEC10A
No data available for UniProtKB/Swiss-Prot and Genatlas for CLEC10A Gene
Publications for CLEC10A Gene
- Molecular cloning and expression of cDNA encoding human macrophage c- type lectin: its unique carbohydrate binding specificity for Tn antigen. (PMID: 8598452) Suzuki N. … Irimura T. (J. Immunol. 1996) 2 3 4 23 67
- The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions. (PMID: 26147970) Zizzari I.G. … Napoletano C. (PLoS ONE 2015) 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- Protein domain histochemistry (PDH): binding of the carbohydrate recognition domain (CRD) of recombinant human glycoreceptor CLEC10A (CD301) to formalin-fixed, paraffin-embedded breast cancer tissues. (PMID: 23275449) Nollau P. … Wagener C. (J. Histochem. Cytochem. 2013) 3
- Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. (PMID: 23383108) Denner J. … AkyA1z L. (PLoS ONE 2013) 3
Products for CLEC10A Gene
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- antibodies-online Antibodies for CLEC10A: See all 113
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- ViGene Biosciences adenoviral particle packaged cDNA for CLEC10A gene
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Sources for CLEC10A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
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- (93) GenomeRNAi
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- (95) miRTarBase
- (96) MalaCards
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