CLEC10A Gene

Aliases
for CLEC10A gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC17M006919 GC17M006923 GC17M006871

Summaries
for CLEC10A gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CLEC10A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000017.10  NT_010718.17  NC_018928.2  

SwitchGear Promoter luciferase reporter plasmid: CLEC10A promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLEC10A

CLEC10A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M006977:  view genomic region     (about GC identifiers)

Proteins
for CLEC10A gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for CLEC10A: NX_Q8IUN9

Explore proteomics data for CLEC10A at MOPED

Post-translational modifications: 

CLEC10A Human Recombinant Protein Products:

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	antibodies-online peptides for CLEC10A

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Domains /
Families
for CLEC10A gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q8IUN9

Find genes that share domains with CLEC10A           About GenesLikeMe

Function
for CLEC10A gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

(inferred from 1 allele) (MGI details for Mgl2)

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC10A

Localization
for CLEC10A gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	4
chloroplast	2
extracellular	2
mitochondrion	2
nucleus	2
cytosol	1
endoplasmic reticulum	1
peroxisome	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for CLEC10A gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for CLEC10A gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CLEC10A gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CLEC10A gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CLEC10A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAGGTATAAT

About this image

Blood (Hematopoietic System)
Monocytes Peripheral Blood

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLEC10A

Orthologs
for CLEC10A gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CLEC10A gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CLEC10A gene

CD207²  CLEC17A²  CLEC4E²  ASGR2²  CLEC4M²  CLEC4F²  CD209²  CLEC4A²  

FCER2²  CLEC6A²  ASGR1²  CLEC4C²  CLEC4D²  CLEC4G²  

18 SIMAP similar genes for CLEC10A using alignment to 4 protein entries:     CLC10_HUMAN (see all proteins):

ASGR1    HBXBP    FCER2    ASGR2    KLRF1    CLEC2D

CLEC4C    KLRG1    OLR1    CLEC4E    CLEC6A    CLEC2L

KLRC1    REG1B    CLEC1B    CD209    CLEC4A    KLRC2

Find genes that share paralogs with CLEC10A           About GenesLikeMe

Genomic Variants
for CLEC10A gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CLEC10A (see all 289)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs769310261,2	C	--	6965261(+)	CAGAGA/CCAGCC	2	--	ds5001		0	--	--	--	--
rs1832629131,2		--	6965334(+)	GACCAC/TGGACG	2	--	ds5001		0	--	--	--	--
rs4157041,2	C,F,A,H	--	6965548(-)	TTAGGG/ATGATT	2	--	ds5001		22		NS EA NA WA CSA	1178
rs1869879671,2		--	6965632(+)	TCACAC/TAGGAC	2	--	ds5001		0	--	--	--	--
rs2011633431,2		--	6965683(+)	GATTG-/CCCAAA	2	--	ds5001		0	--	--	--	--
rs1491058061,2	C	--	6965756(+)	TACACA/GAGAGT	2	--	ut31		0	--	--	--	--
rs1164286931,2	F	--	6965775(+)	TCACTT/GATATG	2	--	ut31		1		WA	118
rs16982251,2	C,F,H	--	6965860(-)	CCAACC/GACTTC	2	--	ut31 ese3		15		EA NA NS CSA WA	970
rs37857981,2	C,F,H	--	6965919(-)	CGATCG/ACAATA	2	--	ut31 ese3		8		NS EA	968
rs37857961,2	C	--	6966032(-)	CCAACG/TTTTGA	2	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for CLEC10A (6977856 - 6983626 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for CLEC10A:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2669929	CNV	Deletion	23128226
esv2422288	CNV	Deletion	17116639
esv2657406	CNV	Deletion	23128226
esv5167	CNV	Deletion	18987735
nsv907635	CNV	Loss	21882294
nsv457659	CNV	Loss	19166990

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CLEC10A

DNA2.0 Custom Variant and Variant Library Synthesis for CLEC10A

Disorders / Diseases
for CLEC10A gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for CLEC10A gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CLEC10A gene, integrated from 10 sources (see all 17): (articles sorted by number of sources associating them with CLEC10A)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular cloning and expression of cDNA encoding human macrophage c- type lectin: its unique carbohydrate binding specificity for Tn antigen. (PubMed id 8598452)^{1, 2, 3, 9} Suzuki N.... Irimura T. (J. Immunol. 1996)
2. Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP. (PubMed id 19776380)^{1, 4} Iijima M....Sobue G. (Neurology 2009)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). (PubMed id 23918927)¹ van Vliet S.J....van Kooyk Y. (J. Biol. Chem. 2013)
5. MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-I+ secretion. (PubMed id 23744646)¹ van Vliet S.J....van Kooyk Y. (J. Leukoc. Biol. 2013)
6. Protein domain histochemistry (PDH): binding of the carbohydrate recognition domain (CRD) of recombinant human glycoreceptor CLEC10A (CD301) to formalin-fixed, paraffin-embedded breast cancer tissues. (PubMed id 23275449)¹ Nollau P....Wagener C. (J. Histochem. Cytochem. 2013)
7. Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation. (PubMed id 22531918)¹ Napoletano C....Nuti M. (Eur. J. Immunol. 2012)
8. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (Genes Immun. 2010)
9. Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses. (PubMed id 19834553)¹ van Vliet S.J....van Kooyk Y. (PLoS Pathog. 2009)
10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (Nat. Genet. 2004)

External Searches for CLEC10A gene

Genome Databases showing CLEC10A gene

Other Databases showing CLEC10A gene

Specialized Databases showing CLEC10A gene

Products
for CLEC10A gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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