Aliases for CLEC10A Gene
Aliases for CLEC10A Gene
- C-Type Lectin Domain Containing 10A 2 3 5
- C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 14 (Macrophage-Derived) 2 3
- Macrophage Lectin 2 (Calcium Dependent) 2 3
- C-Type Lectin Domain Family 10 Member A 2 3
- CLECSF13 3 4
- CLECSF14 3 4
- HML 3 4
- C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 13 (Macrophage-Derived) 3
External Ids for CLEC10A Gene
- HGNC: 16916
- Entrez Gene: 10462
- Ensembl: ENSG00000132514
- OMIM: 605999
- UniProtKB: Q8IUN9
Previous HGNC Symbols for CLEC10A Gene
- CLECSF13
- CLECSF14
Previous GeneCards Identifiers for CLEC10A Gene
- GC17M006919
- GC17M006923
- GC17M006977
- GC17M006871
Summaries for CLEC10A Gene
-
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLEC10A Gene
CLEC10A (C-Type Lectin Domain Containing 10A) is a Protein Coding gene. Among its related pathways are CLEC7A (Dectin-1) signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ASGR1.
UniProtKB/Swiss-Prot for CLEC10A Gene
-
Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.
Additional gene information for CLEC10A Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC10A Gene
Genomics for CLEC10A Gene
GeneHancer (GH) Regulatory Elements for CLEC10A Gene
- Top Transcription factor binding sites by QIAGEN in the CLEC10A gene promoter:
Regulatory Element Products
Genomic Locations for CLEC10A Gene
- chr17:7,074,537-7,080,601
- (GRCh38/hg38)
- Size:
- 6,065 bases
- Orientation:
- Minus strand
- chr17:6,977,856-6,983,626
- (GRCh37/hg19)
Genomic View for CLEC10A Gene
- Cytogenetic band:
-
- 17p13.1 by Ensembl
- 17p13.1 by Entrez Gene
- 17p13.1 by HGNC


RefSeq DNA sequence for CLEC10A Gene
Proteins for CLEC10A Gene
-
Protein details for CLEC10A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IUN9-CLC10_HUMAN
- Recommended name:
- C-type lectin domain family 10 member A
- Protein Accession:
- Q8IUN9
- A8K8J8
- Q14538
- Q6PIW3
Protein attributes for CLEC10A Gene
- Size:
- 316 amino acids
- Molecular mass:
- 35446 Da
- Quaternary structure:
- No Data Available
Protein Expression for CLEC10A Gene
Post-translational modifications for CLEC10A Gene
- Glycosylation at posLast=7878 and Asn173
Other Protein References for CLEC10A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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Protein Products
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Assay Products
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No data available for DME Specific Peptides for CLEC10A Gene
Domains & Families for CLEC10A Gene
Gene Families for CLEC10A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CLEC10A Gene
Suggested Antigen Peptide Sequences for CLEC10A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CLEC10A Gene
Function for CLEC10A Gene
Molecular function for CLEC10A Gene
- UniProtKB/Swiss-Prot Function:
- Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.
Phenotypes From GWAS Catalog for CLEC10A Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0030246 | carbohydrate binding | TAS,IEA | -- |
Phenotypes for CLEC10A Gene
- MGI mutant phenotypes for CLEC10A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CLEC10A:
Animal Models for CLEC10A Gene
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Clone Products
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-
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CLEC10A
-
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC10A Gene
Localization for CLEC10A Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLEC10A Gene
- Membrane; Single-pass type II membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC10A Gene
Pathways & Interactions for CLEC10A Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | CLEC7A (Dectin-1) signaling | ||
3 | Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) |
.62
|
Pathways by source for CLEC10A Gene
4 Reactome pathways for CLEC10A Gene
Interacting Proteins for CLEC10A Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0006897 | endocytosis | IEA | -- |
GO:0045087 | innate immune response | IEA | -- |
No data available for SIGNOR curated interactions for CLEC10A Gene
Drugs & Compounds for CLEC10A Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
calcium | Approved | Nutra | 0 |
Transcripts for CLEC10A Gene
mRNA/cDNA for CLEC10A Gene
- (7) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (51) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CLEC10A Gene
CRISPR Products
-
OriGene CRISPR knockouts for CLEC10A
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-
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miRNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CLEC10A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||
SP6: |
Expression for CLEC10A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CLEC10A Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC10A Gene
NURSA nuclear receptor signaling pathways regulating expression of CLEC10A Gene:
CLEC10ASOURCE GeneReport for Unigene cluster for CLEC10A Gene:
Hs.54403Evidence on tissue expression from TISSUES for CLEC10A Gene
- Blood(4.3)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for CLEC10A
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No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC10A Gene
Orthologs for CLEC10A Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CLEC10A 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | CLEC10A 33 |
|
||
-- 34 |
|
ManyToMany | |||
cow (Bos Taurus) |
Mammalia | CLEC10A 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Mgl2 33 16 34 |
|
||
Clec10a 34 |
|
OneToMany | |||
rat (Rattus norvegicus) |
Mammalia | Clec10a 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | clec10a 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | LOC101882127 33 |
|
||
si:ch211-283g2.2 34 |
|
ManyToMany | |||
si:ch73-361h17.1 34 |
|
ManyToMany | |||
si:ch211-283g2.3 34 |
|
ManyToMany |
- Species where no ortholog for CLEC10A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CLEC10A Gene
(18) SIMAP similar genes for CLEC10A Gene using alignment to 4 proteins:
Variants for CLEC10A Gene
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000122706 | -- | 7,077,849(-) | T/C | intron_variant | |
rs1000152392 | -- | 7,078,060(-) | G/A | coding_sequence_variant, missense_variant | |
rs1000696172 | -- | 7,079,588(-) | A/G | intron_variant | |
rs1000748691 | -- | 7,079,836(-) | G/A | intron_variant | |
rs1001802485 | -- | 7,078,613(-) | G/A/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2422288 | CNV | deletion | 17116639 |
esv2657406 | CNV | deletion | 23128226 |
esv2669929 | CNV | deletion | 23128226 |
esv5167 | CNV | loss | 18987735 |
nsv1110711 | CNV | insertion | 24896259 |
nsv1119455 | CNV | insertion | 24896259 |
nsv1129588 | CNV | tandem duplication | 24896259 |
nsv1142894 | CNV | tandem duplication | 24896259 |
nsv457659 | CNV | loss | 19166990 |
nsv574322 | CNV | loss | 21841781 |
Additional Variant Information for CLEC10A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CLEC10A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC10A Gene
Disorders for CLEC10A Gene
Additional Disease Information for CLEC10A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CLEC10A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC10A Gene
Publications for CLEC10A Gene
- Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen. (PMID: 8598452) Suzuki N … Irimura T (Journal of immunology (Baltimore, Md. : 1950) 1996) 2 3 4 22 58
- Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP. (PMID: 19776380) Iijima M … Sobue G (Neurology 2009) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Intermediate monocytes are increased in enthesitis-related arthritis, a category of juvenile idiopathic arthritis. (PMID: 27706807) Gaur P … Aggarwal A (Clinical and experimental immunology 2017) 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for CLEC10A Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 136 available CLEC10A Antibodies ranked by validation data
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Sources for CLEC10A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
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