Aliases for CLEC10A Gene
Aliases for CLEC10A Gene
- C-Type Lectin Domain Containing 10A 2 3 5
- C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 14 (Macrophage-Derived) 2 3
- Macrophage Lectin 2 (Calcium Dependent) 2 3
- C-Type Lectin Domain Family 10 Member A 2 3
- CLECSF13 3 4
- CLECSF14 3 4
- HML 3 4
- C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 13 (Macrophage-Derived) 3
External Ids for CLEC10A Gene
- HGNC: 16916
- Entrez Gene: 10462
- Ensembl: ENSG00000132514
- OMIM: 605999
- UniProtKB: Q8IUN9
Previous HGNC Symbols for CLEC10A Gene
- CLECSF13
- CLECSF14
Previous GeneCards Identifiers for CLEC10A Gene
- GC17M006919
- GC17M006923
- GC17M006977
- GC17M006871
Summaries for CLEC10A Gene
-
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLEC10A Gene
CLEC10A (C-Type Lectin Domain Containing 10A) is a Protein Coding gene. Among its related pathways are CLEC7A (Dectin-1) signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ASGR1.
UniProtKB/Swiss-Prot for CLEC10A Gene
-
Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.
Additional gene information for CLEC10A Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC10A Gene
Genomics for CLEC10A Gene
GeneHancer (GH) Regulatory Elements for CLEC10A Gene
Promoters and enhancers for CLEC10A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CLEC10A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CLEC10A gene promoter:
Regulatory Element Products
Genomic Locations for CLEC10A Gene
Genomic Locations for CLEC10A Gene
- chr17:7,074,537-7,080,601
- (GRCh38/hg38)
- Size:
- 6,065 bases
- Orientation:
- Minus strand
- chr17:6,977,856-6,983,626
- (GRCh37/hg19)
Genomic View for CLEC10A Gene
Genes around CLEC10A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by Ensembl
- 17p13.1 by Entrez Gene
- 17p13.1 by HGNC
CLEC10A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CLEC10A Gene
Proteins for CLEC10A Gene
-
Protein details for CLEC10A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IUN9-CLC10_HUMAN
- Recommended name:
- C-type lectin domain family 10 member A
- Protein Accession:
- Q8IUN9
- A8K8J8
- Q14538
- Q6PIW3
Protein attributes for CLEC10A Gene
- Size:
- 316 amino acids
- Molecular mass:
- 35446 Da
- Quaternary structure:
- No Data Available
Protein Expression for CLEC10A Gene
Post-translational modifications for CLEC10A Gene
- Glycosylation at posLast=7878 and Asn173
Other Protein References for CLEC10A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CLEC10A (CLEC10A/CD301)
-
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-
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Protein Products
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-
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-
ProSci Proteins for CLEC10A
-
Abcam proteins for CLEC10A
Assay Products
- antibodies-online: Search results for 1 available CLEC10A Elisa Kits ranked by validation data
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Quality Products:
No data available for DME Specific Peptides for CLEC10A Gene
Domains & Families for CLEC10A Gene
Gene Families for CLEC10A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CLEC10A Gene
Suggested Antigen Peptide Sequences for CLEC10A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CLEC10A Gene
Function for CLEC10A Gene
Molecular function for CLEC10A Gene
- UniProtKB/Swiss-Prot Function:
- Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.
Phenotypes From GWAS Catalog for CLEC10A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030246 | carbohydrate binding | TAS,IEA | -- |
Phenotypes for CLEC10A Gene
- MGI mutant phenotypes for CLEC10A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CLEC10A:
Animal Models for CLEC10A Gene
Animal Model Products
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-
-
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-
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-
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CLEC10A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC10A Gene
Localization for CLEC10A Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLEC10A Gene
- Membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC10A Gene
Pathways & Interactions for CLEC10A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | CLEC7A (Dectin-1) signaling | ||
| 3 | Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) |
.62
|
|
Pathways by source for CLEC10A Gene
4 Reactome pathways for CLEC10A Gene
Interacting Proteins for CLEC10A Gene
Selected Interacting proteins:
ENSP00000254868
Q8IUN9-CLC10_HUMAN
for CLEC10A Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006897 | endocytosis | IEA | -- |
| GO:0045087 | innate immune response | IEA | -- |
No data available for SIGNOR curated interactions for CLEC10A Gene
Drugs & Compounds for CLEC10A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | 0 |
Transcripts for CLEC10A Gene
mRNA/cDNA for CLEC10A Gene
- (7) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (51) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CLEC10A Gene
CRISPR Products
-
OriGene CRISPR knockouts for CLEC10A
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLEC10A
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miRNA Products
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Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for CLEC10A
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-
ViGene Biosciences ready-to-package AAV shRNAs for CLEC10A gene
Clone Products
- Sino Biological Human cDNA Clone for CLEC10A
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CLEC10A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CLEC10A (CLEC10A/CD301)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||
| SP6: |
Expression for CLEC10A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CLEC10A Gene
This gene is overexpressed in Whole Blood (x5.5).
This gene is overexpressed in Heart (61.9) and Fetal Liver (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC10A Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CLEC10A Gene:
CLEC10ASOURCE GeneReport for Unigene cluster for CLEC10A Gene:
Hs.54403Evidence on tissue expression from TISSUES for CLEC10A Gene
- Blood(4.3)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for CLEC10A
- genomics-online: primer clones - Search results for 150 available CLEC10A gene related products
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No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC10A Gene
Orthologs for CLEC10A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CLEC10A 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CLEC10A 33 |
|
||
| -- 34 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | CLEC10A 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mgl2 33 16 34 |
|
||
| Clec10a 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Clec10a 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | clec10a 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101882127 33 |
|
||
| si:ch211-283g2.2 34 |
|
ManyToMany | |||
| si:ch73-361h17.1 34 |
|
ManyToMany | |||
| si:ch211-283g2.3 34 |
|
ManyToMany |
- Species where no ortholog for CLEC10A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CLEC10A Gene
(18) SIMAP similar genes for CLEC10A Gene using alignment to 4 proteins:
Variants for CLEC10A Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000122706 | -- | 7,077,849(-) | T/C | intron_variant | |
| rs1000152392 | -- | 7,078,060(-) | G/A | coding_sequence_variant, missense_variant | |
| rs1000696172 | -- | 7,079,588(-) | A/G | intron_variant | |
| rs1000748691 | -- | 7,079,836(-) | G/A | intron_variant | |
| rs1001802485 | -- | 7,078,613(-) | G/A/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2422288 | CNV | deletion | 17116639 |
| esv2657406 | CNV | deletion | 23128226 |
| esv2669929 | CNV | deletion | 23128226 |
| esv5167 | CNV | loss | 18987735 |
| nsv1110711 | CNV | insertion | 24896259 |
| nsv1119455 | CNV | insertion | 24896259 |
| nsv1129588 | CNV | tandem duplication | 24896259 |
| nsv1142894 | CNV | tandem duplication | 24896259 |
| nsv457659 | CNV | loss | 19166990 |
| nsv574322 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.86;
58.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CLEC10A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CLEC10A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC10A Gene
Disorders for CLEC10A Gene
Additional Disease Information for CLEC10A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CLEC10A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC10A Gene
Publications for CLEC10A Gene
- Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen. (PMID: 8598452) Suzuki N … Irimura T (Journal of immunology (Baltimore, Md. : 1950) 1996) 2 3 4 22 58
- Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP. (PMID: 19776380) Iijima M … Sobue G (Neurology 2009) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Intermediate monocytes are increased in enthesitis-related arthritis, a category of juvenile idiopathic arthritis. (PMID: 27706807) Gaur P … Aggarwal A (Clinical and experimental immunology 2017) 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for CLEC10A Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 136 available CLEC10A Antibodies ranked by validation data
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Sources for CLEC10A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
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