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Aliases for CLEC10A Gene

Aliases for CLEC10A Gene

  • C-Type Lectin Domain Family 10, Member A 2 3
  • CLECSF14 3 4 6
  • HML 3 4 6
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 14 (Macrophage-Derived) 2 3
  • Macrophage Lectin 2 (Calcium Dependent) 2 3
  • CLECSF13 3 4
  • CD301 3 6
  • MGL 3 6
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 13 (Macrophage-Derived) 3
  • C-Type Lectin Domain Family 10 Member A 3
  • C-Type Lectin Superfamily Member 14 4
  • Macrophage Lectin 2 4
  • CD301 Antigen 4
  • HML2 3

External Ids for CLEC10A Gene

Previous Symbols for CLEC10A Gene

  • CLECSF13
  • CLECSF14

Summaries for CLEC10A Gene

Entrez Gene Summary for CLEC10A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLEC10A Gene

CLEC10A (C-Type Lectin Domain Family 10, Member A) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC4D.

UniProtKB/Swiss-Prot for CLEC10A Gene

  • Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.

Gene Wiki entry for CLEC10A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC10A Gene

Genomics for CLEC10A Gene

Genomic Location for CLEC10A Gene

Start:
7,074,537 bp from pter
End:
7,080,307 bp from pter
Size:
5,771 bases
Orientation:
Minus strand

Genomic View for CLEC10A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC10A Gene

Regulatory Elements for CLEC10A Gene

Proteins for CLEC10A Gene

  • Protein details for CLEC10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUN9-CLC10_HUMAN
    Recommended name:
    C-type lectin domain family 10 member A
    Protein Accession:
    Q8IUN9
    Secondary Accessions:
    • A8K8J8
    • Q14538
    • Q6PIW3

    Protein attributes for CLEC10A Gene

    Size:
    316 amino acids
    Molecular mass:
    35446 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLEC10A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC10A Gene

Proteomics data for CLEC10A Gene at MOPED

Post-translational modifications for CLEC10A Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn78 and Asn173

Other Protein References for CLEC10A Gene

No data available for DME Specific Peptides for CLEC10A Gene

Domains for CLEC10A Gene

Gene Families for CLEC10A Gene

HGNC:
  • CD :CD molecules
  • CLEC :C-type lectin domain containing

Suggested Antigen Peptide Sequences for CLEC10A Gene

Graphical View of Domain Structure for InterPro Entry

Q8IUN9

UniProtKB/Swiss-Prot:

CLC10_HUMAN
Domain:
  • Contains 1 C-type lectin domain.:
    • Q8IUN9
genes like me logo Genes that share domains with CLEC10A: view

Function for CLEC10A Gene

Molecular function for CLEC10A Gene

UniProtKB/Swiss-Prot Function: Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.

Gene Ontology (GO) - Molecular Function for CLEC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC10A: view
genes like me logo Genes that share phenotypes with CLEC10A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLEC10A Gene

Localization for CLEC10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC10A Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC10A Gene COMPARTMENTS Subcellular localization image for CLEC10A gene
Compartment Confidence
plasma membrane 4
chloroplast 2
extracellular 2
mitochondrion 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLEC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 8598452
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC10A: view

Pathways for CLEC10A Gene

SuperPathways for CLEC10A Gene

No Data Available

Interacting Proteins for CLEC10A Gene

Gene Ontology (GO) - Biological Process for CLEC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with CLEC10A: view

No data available for Pathways by source for CLEC10A Gene

Compounds for CLEC10A Gene

(1) HMDB Compounds for CLEC10A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for CLEC10A Gene

Compound -log(P) Hits PubMed IDs
galactose 59.4 1
genes like me logo Genes that share compounds with CLEC10A: view

Transcripts for CLEC10A Gene

Unigene Clusters for CLEC10A Gene

C-type lectin domain family 10, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC10A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for CLEC10A Gene

GeneLoc Exon Structure for
CLEC10A
ECgene alternative splicing isoforms for
CLEC10A

Expression for CLEC10A Gene

mRNA expression in normal human tissues for CLEC10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC10A Gene

This gene is overexpressed in Whole Blood (5.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CLEC10A Gene

SOURCE GeneReport for Unigene cluster for CLEC10A Gene Hs.54403

genes like me logo Genes that share expressions with CLEC10A: view

No data available for mRNA Expression by UniProt/SwissProt for CLEC10A Gene

Orthologs for CLEC10A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC10A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC10A 35
  • 98.85 (n)
  • 98.27 (a)
CLEC10A 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLEC10A 35
  • 71.57 (n)
  • 58.82 (a)
CLEC10A 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 22 (a)
ManyToMany
CLEC10A 35
  • 77.03 (n)
  • 66.22 (a)
mouse
(Mus musculus)
Mammalia Clec10a 36
  • 51 (a)
OneToMany
Mgl2 35
  • 68.83 (n)
  • 55.52 (a)
Mgl2 16
Mgl2 36
  • 51 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 26 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Clec10a 35
  • 68.63 (n)
  • 56.54 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia clec10a 35
  • 52.83 (n)
  • 41.96 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882127 35
  • 49.03 (n)
  • 38.12 (a)
si:ch211-283g2.2 36
  • 31 (a)
ManyToMany
si:ch211-283g2.3 36
  • 24 (a)
ManyToMany
si:ch73-361h17.1 36
  • 30 (a)
ManyToMany
Species with no ortholog for CLEC10A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLEC10A Gene

ENSEMBL:
Gene Tree for CLEC10A (if available)
TreeFam:
Gene Tree for CLEC10A (if available)

Paralogs for CLEC10A Gene

Selected SIMAP similar genes for CLEC10A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CLEC10A: view

Variants for CLEC10A Gene

Sequence variations from dbSNP and Humsavar for CLEC10A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs15623 -- 7,075,000(-) GACTC(C/T)TCTCA utr-variant-3-prime
rs90951 - 7,078,078(+) AGAGC(A/G)GAGAC missense, reference
rs314228 -- 7,080,816(-) CTGTG(A/T)GTGAT upstream-variant-2KB
rs314229 -- 7,080,758(-) GCTTG(G/T)GGGGA upstream-variant-2KB
rs314230 -- 7,079,875(-) TAGAT(C/T)GGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC10A Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
esv2669929 CNV Deletion 23128226
nsv907635 CNV Loss 21882294
esv5167 CNV Deletion 18987735
esv2657406 CNV Deletion 23128226

Relevant External Links for CLEC10A Gene

HapMap Linkage Disequilibrium report
CLEC10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC10A Gene

Disorders for CLEC10A Gene

Relevant External Links for CLEC10A

Genetic Association Database (GAD)
CLEC10A
Human Genome Epidemiology (HuGE) Navigator
CLEC10A
genes like me logo Genes that share disorders with CLEC10A: view

No data available for UniProtKB/Swiss-Prot for CLEC10A Gene

Publications for CLEC10A Gene

  1. Molecular cloning and expression of cDNA encoding human macrophage c- type lectin: its unique carbohydrate binding specificity for Tn antigen. (PMID: 8598452) Suzuki N. … Irimura T. (J. Immunol. 1996) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP. (PMID: 19776380) Iijima M. … Sobue G. (Neurology 2009) 3 48
  4. Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses. (PMID: 19834553) van Vliet S.J. … van Kooyk Y. (PLoS Pathog. 2009) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for CLEC10A Gene

Sources for CLEC10A Gene

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