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Aliases for CLEC10A Gene

Aliases for CLEC10A Gene

  • C-Type Lectin Domain Containing 10A 2 3
  • C-Type Lectin Domain Family 10 Member A 2 3 5
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 14 (Macrophage-Derived) 2 3
  • Macrophage Lectin 2 (Calcium Dependent) 2 3
  • CLECSF13 3 4
  • CLECSF14 3 4
  • HML 3 4
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 13 (Macrophage-Derived) 3
  • C-Type Lectin Domain Family 10, Member A 2
  • C-Type Lectin Superfamily Member 14 4
  • Macrophage Lectin 2 4
  • CD301 Antigen 4
  • CD301 3
  • HML2 3
  • MGL 3

External Ids for CLEC10A Gene

Previous HGNC Symbols for CLEC10A Gene

  • CLECSF13
  • CLECSF14

Previous GeneCards Identifiers for CLEC10A Gene

  • GC17M006919
  • GC17M006923
  • GC17M006977
  • GC17M006871

Summaries for CLEC10A Gene

Entrez Gene Summary for CLEC10A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLEC10A Gene

CLEC10A (C-Type Lectin Domain Containing 10A) is a Protein Coding gene. Among its related pathways are Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) and CLEC7A (Dectin-1) signaling. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is ASGR1.

UniProtKB/Swiss-Prot for CLEC10A Gene

  • Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.

Gene Wiki entry for CLEC10A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC10A Gene

Genomics for CLEC10A Gene

Regulatory Elements for CLEC10A Gene

Enhancers for CLEC10A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G007130 2 FANTOM5 Ensembl ENCODE dbSUPER 15.5 -51.6 -51611 4.0 HDGF PKNOX1 MLX AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 CLEC10A SLC16A11 ASGR1 BCL6B EIF5A RPL7AP64 TRAPPC1 CD68 GABARAP SAT2
GH17G007010 1.8 FANTOM5 ENCODE dbSUPER 13 +62.9 62888 13.7 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC DVL2 NLGN2 ENSG00000262089 ZBTB4 SNORD10 NEURL4 CNTROB SNORA48 MIR497HG SENP3
GH17G007120 1.4 Ensembl ENCODE dbSUPER 11.8 -40.6 -40633 1.7 HDGF PKNOX1 ATF1 CBX3 ZNF121 RELB ETV6 IKZF2 CREM SP3 SLC16A11 CLEC10A TNFSF12-TNFSF13 TNFSF12 TRAPPC1 ASGR2 LOC105371512
GH17G007101 0.8 dbSUPER 12.5 -21.3 -21293 1.0 HDGF CTCF ARNT SAP130 FEZF1 ZNF2 RAD21 ZNF335 CTBP1 ARID3A CLEC10A SLC16A11 GC17P007101 GC17P007095 GC17P007094 GC17P007093 GC17P007092 GC17P007091 ASGR2 PIR50426
GH17G007113 1.5 Ensembl ENCODE dbSUPER 5.9 -34.2 -34168 3.1 HDGF FOXA2 MLX ARNT ARID4B YBX1 DMAP1 YY1 ZNF207 SP5 NLGN2 ATP1B2 LOC100996842 SLC16A11 ASGR2 RPL7AP64 CLEC10A PIR50426 GC17P007095 GC17P007101
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLEC10A on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC10A Gene

Chromosome:
17
Start:
7,074,537 bp from pter
End:
7,080,601 bp from pter
Size:
6,065 bases
Orientation:
Minus strand

Genomic View for CLEC10A Gene

Genes around CLEC10A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC10A Gene

Proteins for CLEC10A Gene

  • Protein details for CLEC10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUN9-CLC10_HUMAN
    Recommended name:
    C-type lectin domain family 10 member A
    Protein Accession:
    Q8IUN9
    Secondary Accessions:
    • A8K8J8
    • Q14538
    • Q6PIW3

    Protein attributes for CLEC10A Gene

    Size:
    316 amino acids
    Molecular mass:
    35446 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLEC10A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC10A Gene

Post-translational modifications for CLEC10A Gene

  • Glycosylation at Asn78 and posLast=173173
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CLEC10A (CLEC10A/CD301)
  • Cloud-Clone Corp. Antibodies for CLEC10A

No data available for DME Specific Peptides for CLEC10A Gene

Domains & Families for CLEC10A Gene

Gene Families for CLEC10A Gene

Suggested Antigen Peptide Sequences for CLEC10A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLEC10A: view

No data available for UniProtKB/Swiss-Prot for CLEC10A Gene

Function for CLEC10A Gene

Molecular function for CLEC10A Gene

UniProtKB/Swiss-Prot Function:
Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.

Gene Ontology (GO) - Molecular Function for CLEC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA,TAS --
genes like me logo Genes that share ontologies with CLEC10A: view
genes like me logo Genes that share phenotypes with CLEC10A: view

Animal Models for CLEC10A Gene

MGI Knock Outs for CLEC10A:
  • Mgl2 tm1.1(HBEGF/EGFP)Aiwsk
  • Mgl2 tm1b(KOMP)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CLEC10A Gene

Localization for CLEC10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC10A Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC10A gene
Compartment Confidence
plasma membrane 5
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CLEC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC10A: view

Pathways & Interactions for CLEC10A Gene

genes like me logo Genes that share pathways with CLEC10A: view

Pathways by source for CLEC10A Gene

Interacting Proteins for CLEC10A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000254868%0d%0a9606.ENSP00000310182%0d%0a9606.ENSP00000298556%0d%0a
Selected Interacting proteins: ENSP00000254868 Q8IUN9-CLC10_HUMAN for CLEC10A Gene via STRING IID

Gene Ontology (GO) - Biological Process for CLEC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006897 endocytosis IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with CLEC10A: view

No data available for SIGNOR curated interactions for CLEC10A Gene

Drugs & Compounds for CLEC10A Gene

(1) Drugs for CLEC10A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for CLEC10A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLEC10A: view

Transcripts for CLEC10A Gene

Unigene Clusters for CLEC10A Gene

C-type lectin domain family 10, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC10A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for CLEC10A Gene

GeneLoc Exon Structure for
CLEC10A
ECgene alternative splicing isoforms for
CLEC10A

Expression for CLEC10A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLEC10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC10A Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for CLEC10A Gene

This gene is overexpressed in Heart (61.9) and Fetal Liver (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLEC10A Gene



Protein tissue co-expression partners for CLEC10A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLEC10A Gene:

CLEC10A

SOURCE GeneReport for Unigene cluster for CLEC10A Gene:

Hs.54403

Evidence on tissue expression from TISSUES for CLEC10A Gene

  • Blood(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CLEC10A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC10A Gene

Orthologs for CLEC10A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC10A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC10A 34 35
  • 98.85 (n)
dog
(Canis familiaris)
Mammalia CLEC10A 34
  • 77.03 (n)
-- 35
  • 22 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia CLEC10A 34 35
  • 71.57 (n)
mouse
(Mus musculus)
Mammalia Mgl2 34 16 35
  • 68.83 (n)
Clec10a 35
  • 51 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Clec10a 34
  • 68.63 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 26 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 35 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia clec10a 34
  • 52.83 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101882127 34
  • 49.03 (n)
si:ch211-283g2.2 35
  • 31 (a)
ManyToMany
si:ch73-361h17.1 35
  • 30 (a)
ManyToMany
si:ch211-283g2.3 35
  • 24 (a)
ManyToMany
Species where no ortholog for CLEC10A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLEC10A Gene

ENSEMBL:
Gene Tree for CLEC10A (if available)
TreeFam:
Gene Tree for CLEC10A (if available)

Paralogs for CLEC10A Gene

(18) SIMAP similar genes for CLEC10A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CLEC10A: view

Variants for CLEC10A Gene

Sequence variations from dbSNP and Humsavar for CLEC10A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000122706 -- 7,077,849(+) ATTGT(C/T)ATCTC intron-variant
rs1000152392 -- 7,078,060(+) CAGGA(A/G)ATGGC reference, missense
rs1000696172 -- 7,079,588(+) AAAAA(A/G)AAAGA intron-variant
rs1000748691 -- 7,079,836(+) CCGGA(A/G)TCTTA intron-variant
rs1001802485 -- 7,078,613(+) GGCCC(A/G)TCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC10A Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2657406 CNV deletion 23128226
esv2669929 CNV deletion 23128226
esv5167 CNV loss 18987735
nsv1110711 CNV insertion 24896259
nsv1119455 CNV insertion 24896259
nsv1129588 CNV tandem duplication 24896259
nsv1142894 CNV tandem duplication 24896259
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781

Variation tolerance for CLEC10A Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC10A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC10A Gene

Disorders for CLEC10A Gene

Relevant External Links for CLEC10A

Genetic Association Database (GAD)
CLEC10A
Human Genome Epidemiology (HuGE) Navigator
CLEC10A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC10A

No disorders were found for CLEC10A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC10A Gene

Publications for CLEC10A Gene

  1. Molecular cloning and expression of cDNA encoding human macrophage c- type lectin: its unique carbohydrate binding specificity for Tn antigen. (PMID: 8598452) Suzuki N. … Irimura T. (J. Immunol. 1996) 2 3 4 22 64
  2. Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP. (PMID: 19776380) Iijima M. … Sobue G. (Neurology 2009) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Intermediate monocytes are increased in enthesitis-related arthritis, a category of juvenile idiopathic arthritis. (PMID: 27706807) Gaur P. … Aggarwal A. (Clin. Exp. Immunol. 2017) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CLEC10A Gene

Sources for CLEC10A Gene

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