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Aliases for CLDND2 Gene

Aliases for CLDND2 Gene

  • Claudin Domain Containing 2 2 3 5

External Ids for CLDND2 Gene

Previous GeneCards Identifiers for CLDND2 Gene

  • GC19M056563
  • GC19M051870
  • GC19M048202

Summaries for CLDND2 Gene

GeneCards Summary for CLDND2 Gene

CLDND2 (Claudin Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is ENSG00000269403.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDND2 Gene

Genomics for CLDND2 Gene

Regulatory Elements for CLDND2 Gene

Enhancers for CLDND2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CLDND2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLDND2 Gene

51,366,957 bp from pter
51,369,241 bp from pter
2,285 bases
Minus strand

Genomic View for CLDND2 Gene

Genes around CLDND2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDND2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDND2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDND2 Gene

Proteins for CLDND2 Gene

  • Protein details for CLDND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Claudin domain-containing protein 2
    Protein Accession:

    Protein attributes for CLDND2 Gene

    167 amino acids
    Molecular mass:
    17984 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDND2 Gene

Post-translational modifications for CLDND2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDND2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDND2 Gene

Domains & Families for CLDND2 Gene

Protein Domains for CLDND2 Gene

Suggested Antigen Peptide Sequences for CLDND2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PMP-22/EMP/MP20 family.
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with CLDND2: view

No data available for Gene Families for CLDND2 Gene

Function for CLDND2 Gene

genes like me logo Genes that share phenotypes with CLDND2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDND2 Gene

Localization for CLDND2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDND2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CLDND2 Gene COMPARTMENTS Subcellular localization image for CLDND2 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CLDND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLDND2: view

Pathways & Interactions for CLDND2 Gene

SuperPathways for CLDND2 Gene

No Data Available

Interacting Proteins for CLDND2 Gene

Selected Interacting proteins: Q8NHS1-CLDN2_HUMAN for CLDND2 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CLDND2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CLDND2 Gene

Drugs & Compounds for CLDND2 Gene

No Compound Related Data Available

Transcripts for CLDND2 Gene

mRNA/cDNA for CLDND2 Gene

Unigene Clusters for CLDND2 Gene

Claudin domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDND2 Gene

No ASD Table

Relevant External Links for CLDND2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLDND2 Gene

mRNA expression in normal human tissues for CLDND2 Gene

mRNA differential expression in normal tissues according to GTEx for CLDND2 Gene

This gene is overexpressed in Testis (x9.4) and Whole Blood (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of CLDND2 Gene:


SOURCE GeneReport for Unigene cluster for CLDND2 Gene:

genes like me logo Genes that share expression patterns with CLDND2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CLDND2 Gene

Orthologs for CLDND2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLDND2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLDND2 34
  • 82.93 (n)
  • 76.51 (a)
  • 76 (a)
(Canis familiaris)
Mammalia CLDND2 34
  • 84.14 (n)
  • 76.51 (a)
(Mus musculus)
Mammalia Cldnd2 34
  • 74.65 (n)
  • 70.06 (a)
Cldnd2 16
Cldnd2 35
  • 70 (a)
(Pan troglodytes)
Mammalia CLDND2 34
  • 99.8 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Cldnd2 34
  • 76.65 (n)
  • 72.46 (a)
(Ornithorhynchus anatinus)
Mammalia CLDND2 35
  • 48 (a)
Species where no ortholog for CLDND2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLDND2 Gene

Gene Tree for CLDND2 (if available)
Gene Tree for CLDND2 (if available)

Paralogs for CLDND2 Gene

Paralogs for CLDND2 Gene

genes like me logo Genes that share paralogs with CLDND2: view

Variants for CLDND2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CLDND2 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for CLDND2 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.09; 68.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLDND2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CLDND2 Gene

Disorders for CLDND2 Gene

Relevant External Links for CLDND2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLDND2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDND2 Gene

Publications for CLDND2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 65

Products for CLDND2 Gene

Sources for CLDND2 Gene

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