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Aliases for CLDND1 Gene

Aliases for CLDND1 Gene

  • Claudin Domain Containing 1 2 3
  • Membrane Protein GENX-3745 3 4
  • C3orf4 3 4
  • Claudin Domain Containing 1 Protein 3
  • Claudin Domain-Containing Protein 1 3
  • Chromosome 3 Open Reading Frame 4 2
  • GENX-3745 3

External Ids for CLDND1 Gene

Previous Symbols for CLDND1 Gene

  • C3orf4

Summaries for CLDND1 Gene

GeneCards Summary for CLDND1 Gene

CLDND1 (Claudin Domain Containing 1) is a Protein Coding gene.

Gene Wiki entry for CLDND1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDND1 Gene

Genomics for CLDND1 Gene

Genomic Location for CLDND1 Gene

Start:
98,497,912 bp from pter
End:
98,523,066 bp from pter
Size:
25,155 bases
Orientation:
Minus strand

Genomic View for CLDND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLDND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDND1 Gene

Regulatory Elements for CLDND1 Gene

Proteins for CLDND1 Gene

  • Protein details for CLDND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY35-CLDN1_HUMAN
    Recommended name:
    Claudin domain-containing protein 1
    Protein Accession:
    Q9NY35
    Secondary Accessions:
    • B3KQR1
    • D3DN36
    • F2Z2D9
    • Q502Y8
    • Q6UVX2
    • Q9BUZ9
    • Q9NZZ5
    • Q9Y4S9

    Protein attributes for CLDND1 Gene

    Size:
    253 amino acids
    Molecular mass:
    28603 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF29137.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CLDND1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLDND1 Gene

Proteomics data for CLDND1 Gene at MOPED

Post-translational modifications for CLDND1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn42 and Asn72

No data available for DME Specific Peptides for CLDND1 Gene

Domains for CLDND1 Gene

Protein Domains for CLDND1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CLDN1_HUMAN
Family:
  • Belongs to the PMP-22/EMP/MP20 family.:
    • Q9NY35
genes like me logo Genes that share domains with CLDND1: view

No data available for Gene Families for CLDND1 Gene

Function for CLDND1 Gene

Phenotypes for CLDND1 Gene

genes like me logo Genes that share phenotypes with CLDND1: view

miRNA for CLDND1 Gene

miRTarBase miRNAs that target CLDND1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLDND1 Gene

Localization for CLDND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDND1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDND1 Gene COMPARTMENTS Subcellular localization image for CLDND1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CLDND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IDA 19581412
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with CLDND1: view

Pathways for CLDND1 Gene

SuperPathways for CLDND1 Gene

No Data Available

Interacting Proteins for CLDND1 Gene

Gene Ontology (GO) - Biological Process for CLDND1 Gene

None

No data available for Pathways by source for CLDND1 Gene

Transcripts for CLDND1 Gene

Unigene Clusters for CLDND1 Gene

Claudin domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLDND1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - -
SP17: - - - - - - - -
SP18: - - - - - -
SP19: - - - -
SP20: - - - - - - - - - - - - - - -
SP21: - - - - - -
SP22: - - - - - - - - - - -
SP23: - - - - -
SP24: - - -
SP25: - - - - - - - - -
SP26: - - - - - - -
SP27: - -
SP28:

ExUns: 9d ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13: -
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19: -
SP20: -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28: -

Relevant External Links for CLDND1 Gene

GeneLoc Exon Structure for
CLDND1
ECgene alternative splicing isoforms for
CLDND1

Expression for CLDND1 Gene

mRNA expression in normal human tissues for CLDND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDND1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (10.9) and Brain - Substantia nigra (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CLDND1 Gene

SOURCE GeneReport for Unigene cluster for CLDND1 Gene Hs.531371

mRNA Expression by UniProt/SwissProt for CLDND1 Gene

Q9NY35-CLDN1_HUMAN
Tissue specificity: Widely distributed in the adult CNS with highest expression in the corpus callosum, caudate nucleus, cerebral cortex, medulla, putamen, spinal cord, substantia nigra and subthalamic nucleus. Weak expression was detected in the adult heart
genes like me logo Genes that share expressions with CLDND1: view

Orthologs for CLDND1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLDND1 36
  • 99.76 (n)
  • 99.64 (a)
CLDND1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLDND1 36
  • 93.02 (n)
  • 95.26 (a)
CLDND1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLDND1 36
  • 92.39 (n)
  • 95.29 (a)
CLDND1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cldn25 36
  • 86.35 (n)
  • 92.39 (a)
Cldn25 16
Cldn25 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLDND1 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLDND1 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldnd1 36
  • 85.64 (n)
  • 91.3 (a)
chicken
(Gallus gallus)
Aves CLDND1 36
  • 74.06 (n)
  • 81.85 (a)
CLDND1 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 65 (a)
OneToMany
-- 37
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cldnd1 36
  • 60.64 (n)
  • 59.04 (a)
zebrafish
(Danio rerio)
Actinopterygii CLDND1 (1 of 2) 37
  • 51 (a)
OneToMany
CLDND1 (2 of 2) 37
  • 51 (a)
OneToMany
LOC554386 36
  • 57.35 (n)
  • 53.44 (a)
Species with no ortholog for CLDND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDND1 Gene

ENSEMBL:
Gene Tree for CLDND1 (if available)
TreeFam:
Gene Tree for CLDND1 (if available)

Paralogs for CLDND1 Gene

No data available for Paralogs for CLDND1 Gene

Variants for CLDND1 Gene

Sequence variations from dbSNP and Humsavar for CLDND1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1729975 -- 98,520,610(+) ACCTA(A/C)CAACT intron-variant
rs1729994 -- 98,524,197(-) TCTCC(A/G)TCACT upstream-variant-2KB
rs2178323 -- 98,524,196(-) CTCCA(C/T)CACTT upstream-variant-2KB
rs2306065 -- 98,522,496(-) AATCA(A/G)AATAC intron-variant
rs6799550 -- 98,523,259(+) TTAGA(C/T)CTGAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLDND1 Gene

Variant ID Type Subtype PubMed ID
dgv293n21 CNV Loss 19592680
nsv834774 CNV Loss 17160897
nsv834775 CNV Gain 17160897

Relevant External Links for CLDND1 Gene

HapMap Linkage Disequilibrium report
CLDND1

Disorders for CLDND1 Gene

Relevant External Links for CLDND1

Genetic Association Database (GAD)
CLDND1
Human Genome Epidemiology (HuGE) Navigator
CLDND1
genes like me logo Genes that share disorders with CLDND1: view

No data available for UniProtKB/Swiss-Prot for CLDND1 Gene

Publications for CLDND1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  5. Characterization of tissue expression and full-length coding sequence of a novel human gene mapping at 3q12.1 and transcribed in oligodendrocytes. (PMID: 12036590) Fayein N.-A. … Devignes M.-D. (Gene 2002) 3 4

Products for CLDND1 Gene

  • antibodies-online peptides for CLDND1
  • antibodies-online antibodies for CLDND1
  • antibodies-online kits for CLDND1

Sources for CLDND1 Gene

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