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Aliases for CLDND1 Gene

Aliases for CLDND1 Gene

  • Claudin Domain Containing 1 2 3 5
  • Membrane Protein GENX-3745 3 4
  • C3orf4 3 4
  • Claudin Domain Containing 1 Protein 3
  • Chromosome 3 Open Reading Frame 4 2
  • GENX-3745 3

External Ids for CLDND1 Gene

Previous HGNC Symbols for CLDND1 Gene

  • C3orf4

Previous GeneCards Identifiers for CLDND1 Gene

  • GC03M099718
  • GC03M098234
  • GC03M095606

Summaries for CLDND1 Gene

GeneCards Summary for CLDND1 Gene

CLDND1 (Claudin Domain Containing 1) is a Protein Coding gene.

Gene Wiki entry for CLDND1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDND1 Gene

Genomics for CLDND1 Gene

Regulatory Elements for CLDND1 Gene

Enhancers for CLDND1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLDND1 on UCSC Golden Path with GeneCards custom track

Promoters for CLDND1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLDND1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLDND1 Gene

Chromosome:
3
Start:
98,497,912 bp from pter
End:
98,523,066 bp from pter
Size:
25,155 bases
Orientation:
Minus strand

Genomic View for CLDND1 Gene

Genes around CLDND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDND1 Gene

Proteins for CLDND1 Gene

  • Protein details for CLDND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY35-CLDN1_HUMAN
    Recommended name:
    Claudin domain-containing protein 1
    Protein Accession:
    Q9NY35
    Secondary Accessions:
    • B3KQR1
    • D3DN36
    • F2Z2D9
    • Q502Y8
    • Q6UVX2
    • Q9BUZ9
    • Q9NZZ5
    • Q9Y4S9

    Protein attributes for CLDND1 Gene

    Size:
    253 amino acids
    Molecular mass:
    28603 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF29137.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CLDND1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLDND1 Gene

Proteomics data for CLDND1 Gene at MOPED

Post-translational modifications for CLDND1 Gene

  • Glycosylation at Asn 42 and Asn 72
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLDND1 Gene

Domains & Families for CLDND1 Gene

Protein Domains for CLDND1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLDND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NY35

UniProtKB/Swiss-Prot:

CLDN1_HUMAN :
  • Belongs to the PMP-22/EMP/MP20 family.
Family:
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with CLDND1: view

No data available for Gene Families for CLDND1 Gene

Function for CLDND1 Gene

genes like me logo Genes that share phenotypes with CLDND1: view

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLDND1 Gene

Localization for CLDND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDND1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDND1 Gene COMPARTMENTS Subcellular localization image for CLDND1 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CLDND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with CLDND1: view

Pathways & Interactions for CLDND1 Gene

SuperPathways for CLDND1 Gene

No Data Available

Interacting Proteins for CLDND1 Gene

Gene Ontology (GO) - Biological Process for CLDND1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLDND1 Gene

Drugs & Compounds for CLDND1 Gene

No Compound Related Data Available

Transcripts for CLDND1 Gene

Unigene Clusters for CLDND1 Gene

Claudin domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLDND1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - -
SP17: - - - - - - - -
SP18: - - - - - -
SP19: - - - -
SP20: - - - - - - - - - - - - - - -
SP21: - - - - - -
SP22: - - - - - - - - - - -
SP23: - - - - -
SP24: - - -
SP25: - - - - - - - - -
SP26: - - - - - - -
SP27: - -
SP28:

ExUns: 9d ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13: -
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19: -
SP20: -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28: -

Relevant External Links for CLDND1 Gene

GeneLoc Exon Structure for
CLDND1
ECgene alternative splicing isoforms for
CLDND1

Expression for CLDND1 Gene

mRNA expression in normal human tissues for CLDND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDND1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.9) and Brain - Substantia nigra (x5.7).

Protein differential expression in normal tissues from HIPED for CLDND1 Gene

This gene is overexpressed in Spinal cord (23.0), Frontal cortex (14.7), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CLDND1 Gene



SOURCE GeneReport for Unigene cluster for CLDND1 Gene Hs.531371

mRNA Expression by UniProt/SwissProt for CLDND1 Gene

Q9NY35-CLDN1_HUMAN
Tissue specificity: Widely distributed in the adult CNS with highest expression in the corpus callosum, caudate nucleus, cerebral cortex, medulla, putamen, spinal cord, substantia nigra and subthalamic nucleus. Weak expression was detected in the adult heart.
genes like me logo Genes that share expression patterns with CLDND1: view

Protein tissue co-expression partners for CLDND1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CLDND1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDND1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLDND1 35
  • 93.02 (n)
  • 95.26 (a)
CLDND1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLDND1 35
  • 92.39 (n)
  • 95.29 (a)
CLDND1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cldn25 35
  • 86.35 (n)
  • 92.39 (a)
Cldnd1 16
Cldn25 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLDND1 35
  • 99.76 (n)
  • 99.64 (a)
CLDND1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldnd1 35
  • 85.64 (n)
  • 91.3 (a)
oppossum
(Monodelphis domestica)
Mammalia CLDND1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLDND1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLDND1 35
  • 74.06 (n)
  • 81.85 (a)
CLDND1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cldnd1 35
  • 60.64 (n)
  • 59.04 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC554386 35
  • 57.35 (n)
  • 53.44 (a)
CLDND1 (1 of 2) 36
  • 51 (a)
OneToMany
CLDND1 (2 of 2) 36
  • 51 (a)
OneToMany
Species with no ortholog for CLDND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDND1 Gene

ENSEMBL:
Gene Tree for CLDND1 (if available)
TreeFam:
Gene Tree for CLDND1 (if available)

Paralogs for CLDND1 Gene

No data available for Paralogs for CLDND1 Gene

Variants for CLDND1 Gene

Sequence variations from dbSNP and Humsavar for CLDND1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11553641 -- 98,517,098(-) TGCCG(A/T)AGCTT reference, synonymous-codon
rs11553644 -- 98,515,754(+) TGGCT(A/C/G/T)TCCAT utr-variant-3-prime
rs11553649 -- 98,516,737(-) TTCAT(G/T)GCTTC reference, missense
rs34144033 -- 98,519,065(+) TATTC(-/C)TCTGA intron-variant
rs73856733 -- 98,515,150(+) ACTTG(G/T)TTATT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CLDND1 Gene

Variant ID Type Subtype PubMed ID
dgv293n21 CNV Loss 19592680
nsv834774 CNV Loss 17160897
nsv834775 CNV Gain 17160897

Variation tolerance for CLDND1 Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLDND1 Gene

HapMap Linkage Disequilibrium report
CLDND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDND1 Gene

Disorders for CLDND1 Gene

Relevant External Links for CLDND1

Genetic Association Database (GAD)
CLDND1
Human Genome Epidemiology (HuGE) Navigator
CLDND1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLDND1

No disorders were found for CLDND1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDND1 Gene

Publications for CLDND1 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. (PMID: 19581412) Teckchandani A. … Cooper J.A. (J. Cell Biol. 2009) 3
  4. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for CLDND1 Gene

Sources for CLDND1 Gene

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