External Ids for CLDN9 Gene
Previous GeneCards Identifiers for CLDN9 Gene
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein is one of the entry cofactors for hepatitis C virus. Mouse studies revealed that this gene is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness. [provided by RefSeq, Jun 2010]
GeneCards Summary for CLDN9 Gene
CLDN9 (Claudin 9) is a Protein Coding gene. Diseases associated with CLDN9 include Hepatitis C Virus and Deafness, Autosomal Recessive 49. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN6.
UniProtKB/Swiss-Prot for CLDN9 Gene
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity). May act as a coreceptor for HCV entry into hepatic cells.