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CLDN8 Gene

protein-coding   GIFtS: 60
GCID: GC21M031586

Claudin 8

  See CLDN8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Claudin 81 2
Human CLDN8 Gene For Claudin-811
claudin-82

External Ids:    HGNC: 20501   Entrez Gene: 90732   Ensembl: ENSG000001562847   OMIM: 6112315   UniProtKB: P567483   

Export aliases for CLDN8 gene to outside databases

Previous GC identifers: GC21M028163 GC21M028246 GC21M030507 GC21M030508 GC21M030509 GC21M016995


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLDN8 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular
cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in
distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell
tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe
renal cell carcinoma and renal oncocytoma.(provided by RefSeq, May 2010)

GeneCards Summary for CLDN8 Gene:
CLDN8 (claudin 8) is a protein-coding gene. Diseases associated with CLDN8 include oxyphilic adenoma, and chromophobe renal cell carcinoma. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is CLDN4.

UniProtKB/Swiss-Prot: CLD8_HUMAN, P56748
Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

Gene Wiki entry for CLDN8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLDN8 gene promoter:
         STAT1   STAT4   STAT6   STAT1beta   STAT5A   CUTL1   STAT1alpha   GATA-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN8 promoter sequence

   Search Chromatin IP Primers for CLDN8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.11
CLDN8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN8 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M031586:   GeneLoc Nature:405,311-319
Start:
31,586,324 bp from pter       17,163,042 bp from centromere
End:
31,588,469 bp from pter 17,164,972 bp from centromere
Size:
2,146 bases 1,931 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AJ250711
genomic clones: R463J19


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLD8_HUMAN, P56748 (See protein sequence)
Recommended Name: Claudin-8  
Size: 225 amino acids; 24845 Da
Subunit: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity)
Miscellaneous: A protein of the expected size has been detected by antibody binding and Western blot in at least
one of the analyzed tissues or cells (PubMed:22042635)
Secondary accessions: D3DSE3 Q53EX7

Explore the universe of human proteins at neXtProt for CLDN8: NX_P56748

Explore proteomics data for CLDN8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLDN8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_955360.1  
    ENSEMBL proteins: 
     ENSP00000382783   ENSP00000286809  
    Reactome Protein details: P56748

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR003926 Claudin8
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry P56748

    ProtoNet protein and cluster: P56748

    2 Blocks protein domains:
    IPB003926 Claudin-8 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD8_HUMAN, P56748
    Similarity: Belongs to the claudin family


    Find genes that share domains with CLDN8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD8_HUMAN, P56748
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

         Genatlas biochemistry entry for CLDN8:
    claudin 8,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major
    structural components of tight junction (TJ) strands,potentially developmentally regulated

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding ISS--
         
    Find genes that share ontologies with CLDN8           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Cldn8 (no phenotypes)

    Find genes that share phenotypes with CLDN8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cldn8tm1Lex for CLDN8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLDN8
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    Selected qRT-PCR Assays for microRNAs that regulate CLDN8 (see all 20):
    hsa-miR-579 hsa-miR-607 hsa-miR-361-5p hsa-miR-330-5p hsa-miR-539 hsa-miR-4263 hsa-miR-3074-3p hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidCLDN8 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat CLDN8

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLD8_HUMAN, P56748: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to
    tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal
    cells, and in the corpus at the interface between basal and principal cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA16780588
    GO:0005886plasma membrane IDA16780588
    GO:0005923tight junction ISS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CLDN8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLDN8 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    5Tight junction
    Tight junction


    Find genes that share SuperPaths with CLDN8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLDN8
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN8
        Cell adhesion Tight junctions

    1 Reactome Pathway for CLDN8
        Tight junction interactions


    4 Kegg Pathways  (Kegg details for CLDN8):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN8: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CLDN8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLDN8 (P567483 ENSP000002868094) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    CLDN1ENSP000002955224STRING: ENSP00000295522
    CLDN10ENSP000002993394STRING: ENSP00000299339
    CLDN11ENSP000000647244STRING: ENSP00000064724
    CLDN14ENSP000003392924STRING: ENSP00000339292
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--

    Find genes that share ontologies with CLDN8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLDN8 (CLD8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLDN8 gene (2 alternative transcripts): 
    NM_199328.2  NM_012132.3  

    Unigene Cluster for CLDN8:

    Claudin 8
    Hs.162209  [show with all ESTs]
    Unigene Representative Sequence: NM_199328
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399899(uc002ynu.2) ENST00000286809
    miRNA
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    hsa-miR-579 hsa-miR-607 hsa-miR-361-5p hsa-miR-330-5p hsa-miR-539 hsa-miR-4263 hsa-miR-3074-3p hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidCLDN8 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat CLDN8

    Additional mRNA sequence: 

    AK022269.1 AK223512.1 AL049977.1 AY358707.1 BC058004.1 

    2 DOTS entries:

    DT.101971566  DT.101980373 

    Selected AceView cDNA sequences (see all 31):

    NM_199328 AW237740 AW205135 BC020866 AW237781 BX283446 BF195920 CB851106 
    AY358707 BF196092 BC058004 BE000282 AW235670 AA769736 AK022269 BG674625 
    BG426438 BV199182 BG402103 AL049977 AU121779 AW999412 BE172635 AA536178 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLDN8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATAGGGTTG
    CLDN8 Expression
    About this image


    CLDN8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Kidney (Urinary System)    fully expand to see all 10 entries
             Loop of Henle Cells Loop of Henle
             Metanephros
     
     Epithelial Cells
             Loop of Henle Cells Loop of Henle
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Somatic Cells Ovigerous Cord
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    CLDN8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLDN8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.162209

    UniProtKB/Swiss-Prot: CLD8_HUMAN, P56748
    Tissue specificity: Expressed in the epididymis, mainly in the caput segment

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN8: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN8 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn81 , 5 claudin 81, 5 82.96(n)1
    82.67(a)1
      16 (51.22 cM)5
    544201  NM_018778.31  NP_061248.11 
     885608285 
    chicken
    (Gallus gallus)
    Aves CLDN81 claudin 8 68.45(n)
    65.18(a)
      427974  XM_004938379.1  XP_004938436.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLDN86
    claudin 8
    59(a)
    1 ↔ 1
    3(146053769-146055592)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1103331 zgc:110333 57.87(n)
    52.81(a)
      550497  NM_001017799.2  NP_001017799.1 


    ENSEMBL Gene Tree for CLDN8 (if available)
    TreeFam Gene Tree for CLDN8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLDN8 gene
    CLDN42  CLDN92  CLDN202  CLDN172  CLDN52  CLDN22  CLDN12  CLDN32  
    CLDN142  CLDN62  CLDN72  CLDN192  
    18 SIMAP similar genes for CLDN8 using alignment to 1 protein entry:     CLD8_HUMAN:
    CLDN17    CLDN4    CLDN7    CLDN9    CLDN19    CLDN5
    CLDN6    CLDN1    CLDN3    CLDN2    CLDN14    CLDN24
    CLDN22    CLDN18    CLDN20    CLDN10    CLDN25    CLDN15

    Find genes that share paralogs with CLDN8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLDN8 (see all 121)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862554921,2
    --31586245(+) TTGGAC/GAATAA 1 -- ds50010--------
    rs1913008931,2
    --31586247(+) GGAGAA/GTAAAA 1 -- ds50010--------
    rs134335071,2
    C,F,H--31586370(+) ATAAAG/ACAAAT 1 -- ut3111Minor allele frequency- A:0.08NS EA NA WA 860
    rs1822500921,2
    --31586485(+) TTTAGA/TAAAAC 1 -- ut310--------
    rs733435741,2
    C--31586571(+) AGGAGC/TAGGTG 1 -- ut312Minor allele frequency- T:0.04WA 120
    rs1131295871,2
    C,F--31586715(+) CCATAC/TATATA 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1864854211,2
    --31586722(+) TATATG/TATTTC 1 -- ut310--------
    rs1908997481,2
    C--31586816(+) ACTTTC/TATCTT 1 -- ut310--------
    rs1414516621,2
    C--31586896(+) AATGTC/TAATTT 1 -- ut310--------
    rs1389415031,2
    C--31587191(+) CATAT-/AAGCAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLDN8 (31586324 - 31588469 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CLDN8: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLDN8
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611231    OMIM disorders: --

    3 diseases for CLDN8:    
    About MalaCards
    oxyphilic adenoma    chromophobe renal cell carcinoma    renal cell carcinoma

    2 diseases from the University of Copenhagen DISEASES database for CLDN8:
    Oxyphilic adenoma     Renal oncocytoma

    Find genes that share disorders with CLDN8           About GenesLikeMe

    2 Novoseek inferred disease relationships for CLDN8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 58.3 8 18799195 (5), 19302533 (1), 18587324 (1)
    tumors 0 5 18799195 (2), 17922590 (1)

    Genetic Association Database (GAD): CLDN8

    Export disorders for CLDN8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLDN8 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with CLDN8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    4. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    5. Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. (PubMed id 18799195)1, 9 Osunkoya A.O....Young A.N. (Hum. Pathol. 2009)
    6. Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation. (PubMed id 19000657)1, 9 Amasheh S....Fromm M. (Biochem. Biophys. Res. Commun. 2009)
    7. Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12. (PubMed id 17047970)1, 9 GrAPne J....Buhr H.J. (Int J Colorectal Dis 2007)
    8. Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma. (PubMed id 19302533)1, 9 Kim S.S....Choi C. (Histopathology 2009)
    9. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)1, 9 Hu Y.H....Janitz M. (BMC Genomics 2006)
    10. Human claudin-8 and -14 are receptors capable of conveying the cytotoxic effects of Clostridium perfringens enterotoxin. (PubMed id 23322640)1 Shrestha A. and McClane B.A. (MBio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9073 HGNC: 2050 AceView: CLDN8 Ensembl:ENSG00000156284 euGenes: HUgn9073
    ECgene: CLDN8 Kegg: 9073 H-InvDB: CLDN8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLDN8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLDN8 gene:
    Search GeneIP for patents involving CLDN8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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