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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN8 Gene

protein-coding   GIFtS: 60
GCID: GC21M031586

claudin 8
 Explore 16 diseases affiliated with
CLDN8 via
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our new
 Human Malady Compendium 
Biological research products
for CLDN8    

Aliases
for CLDN8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
Claudin 81 2
Human CLDN8 Gene For Claudin-811
Claudin-81

External Ids:    HGNC: 20501   Entrez Gene: 90732   Ensembl: ENSG000001562847   OMIM: 6112315   UniProtKB: P567483   

Export aliases for CLDN8 gene to outside databases

Previous GC identifers: GC21M028163 GC21M028246 GC21M030507 GC21M030508 GC21M030509 GC21M016995


Summaries
for CLDN8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLDN8:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely
through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in
maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation
barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon.
Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with
claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and
renal oncocytoma.(provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: CLD8_HUMAN, P56748
Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

Gene Wiki entry for CLDN8


Genomic Views
for CLDN8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN8 gene promoter:
         STAT1   STAT4   STAT6   STAT1beta   STAT5A   CUTL1   STAT1alpha   GATA-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLDN8 promoter sequence

   Search SABiosciences Chromatin IP Primers for CLDN8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.11
CLDN8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN8 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M031586:   GeneLoc Nature:405,311-319
Start:
 31,586,324 bp from pter       17,163,042 bp from centromere
End:
 31,588,469 bp from pter 17,164,972 bp from centromere
Size:
 2,146 bases 1,931 bases
Orientation:
 minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AJ250711
genomic clones: R463J19


Proteins
for CLDN8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLD8_HUMAN, P56748 (See protein sequence)
Recommended Name: Claudin-8  
Size: 225 amino acids; 24845 Da
Subunit: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity)
Subcellular location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to
tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and
in the corpus at the interface between basal and principal cells
Miscellaneous: A protein of the expected size has been detected by antibody binding and Western blot in at least one of
the analyzed tissues or cells (PubMed:22042635)
Secondary accessions: D3DSE3 Q53EX7

Explore the universe of human proteins at neXtProt for CLDN8: NX_P56748

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56748

    • CLDN8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_955360.1  
    ENSEMBL proteins: 
     ENSP00000382783   ENSP00000286809  
    Reactome Protein details: P56748
    Human Recombinant Protein Products: 
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    Novus Biologicals CLDN8 Proteins
    Novus Biologicals CLDN8 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLDN8

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA16780588
    GO:0005886plasma membrane IDA16780588
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane IEA--


    CLDN8 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLDN8

    Protein Domains /
    Families
    for CLDN8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLDN8 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017974 Claudin_CS
     IPR003926 Claudin8
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry P56748

    ProtoNet protein and cluster: P56748

    2 Blocks protein families:
    IPB003926 Claudin-8 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD8_HUMAN, P56748
    Similarity: Belongs to the claudin family


    Function
    for CLDN8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLD8_HUMAN, P56748
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

         Genatlas biochemistry entry for CLDN8:
    claudin 8,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural
    components of tight junction (TJ) strands,potentially developmentally regulated

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN8
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN8 (see all 20):
    hsa-miR-579 hsa-miR-607 hsa-miR-361-5p hsa-miR-330-5p hsa-miR-539 hsa-miR-4263 hsa-miR-3074-3p hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN8 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN8 (see all 7)
    OriGene shRNA RFP: CLDN8
    OriGene siRNA: CLDN8
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CLDN8

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN8 

    Cell Line
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    Search LifeMap BioReagents cell lines for CLDN8

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding ISS--


    CLDN8 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Cldn8tm1Lex for CLDN8
         1 MGI phenotypic allele for Cldn8 (no phenotypes)

    CLDN8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLDN8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Tight junction interactions0.49
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99
    3Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Epithelial Tight Junctions0.36
    4Hepatitis C
    		Hepatitis C1.00
    5Leukocyte transendothelial migration
    		Leukocyte transendothelial migration1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CLDN8
        Cell adhesion Tight junctions

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN8
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN8
        Cell adhesion Tight junctions

    4        Reactome Pathways for CLDN8
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN8):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/25 Interacting proteins for CLDN8 (P567483 ENSP000002868094) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    CLDN1ENSP000002955224STRING: ENSP00000295522
    CLDN10ENSP000002993394STRING: ENSP00000299339
    CLDN11ENSP000000647244STRING: ENSP00000064724
    CLDN14ENSP000003392924STRING: ENSP00000339292
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--


    CLDN8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLDN8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN8
    Search CenterWatch for drugs/clinical trials and news about CLDN8 / CLD8 

    Transcripts
    for CLDN8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLDN8 gene (2 alternative transcripts): 
    NM_199328.2  NM_012132.3  

    Unigene Cluster for CLDN8:

    Claudin 8
    Hs.162209  [show with all ESTs]
    Unigene Representative Sequence: NM_199328
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399899(uc002ynu.2) ENST00000286809

    miRNA
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN8 (see all 20):
    hsa-miR-579 hsa-miR-607 hsa-miR-361-5p hsa-miR-330-5p hsa-miR-539 hsa-miR-4263 hsa-miR-3074-3p hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN8 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN8 (see all 7)
    OriGene shRNA RFP: CLDN8
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN8
    Clone
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    GenScript: all cDNA clones in your preferred vector: CLDN8 (NM_199328)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN8

    Additional cDNA sequence: 

    AK022269.1 AK223512.1 AL049977.1 AY358707.1 BC058004.1 

    2 DOTS entries:

    DT.101971566  DT.101980373 

    24/31 AceView cDNA sequences (see all 31):

    AY358707 BC020866 BC058004 AW237740 BF196092 AW237781 CB851106 BF195920 
    AW205135 BX283446 NM_199328 BV199182 BG402103 AK022269 AL049977 BG674625 
    BG426438 AW235670 AU121779 AA769736 BE000282 AW999412 BE172635 AA536178 

    GeneLoc Exon Structure


    Expression
    for CLDN8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATAGGGTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLDN8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyDistal TubuleDistal Tubule CellsKidney
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyRenal Collecting Duct SystemCollecting Duct CellsKidney
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    KidneyUreteric BudUreteric Bud CellsKidney
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    OvaryOvigerous CordOvarian Somatic CellsOvary
    Gut TubeHindgutGut Tube
    Gut TubeMidgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CLDN8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN8

    SOURCE GeneReport for Unigene cluster: Hs.162209

    UniProtKB/Swiss-Prot: CLD8_HUMAN, P56748
    Tissue specificity: Expressed in the epididymis, mainly in the caput segment

        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN8: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN8

    Orthologs
    for CLDN8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN8 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CLDN81 claudin 8 68.3(n)
    65.18(a)    		   427974  XM_425544.2  XP_425544.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CLDN86
    		 --
    		 60(a)
    		 1 ↔ 1
    		 3(146053769-146055592)
    zebrafish
    (Danio rerio)    		 Actinopterygii cldn81 claudin 8 58.21(n)
    53.3(a)    		   445278  NM_001003733.1  NP_001003733.1 


    ENSEMBL Gene Tree for CLDN8 (if available)
    TreeFam Gene Tree for CLDN8 (if available) 

    Paralogs
    for CLDN8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN8 gene
    CLDN92  CLDN42  CLDN202  CLDN172  CLDN52  CLDN22  CLDN102  CLDN152  
    CLDN32  CLDN12  CLDN142  CLDN62  CLDN72  CLDN192  
    18 SIMAP similar genes for CLDN8 using alignment to 1 protein entry:     CLD8_HUMAN:
    CLDN17    CLDN4    CLDN7    CLDN9    CLDN19    CLDN5
    CLDN6    CLDN1    CLDN3    CLDN2    CLDN14    CLDN24
    CLDN22    CLDN18    CLDN20    CLDN10    CLDN25    CLDN15

    CLDN8 for paralogs           About GeneDecksing



    Genomic Variants
    for CLDN8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/104 NCBI SNPs in CLDN8 are shown (see all 104)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1458042441,2
    		--31585831(+) GAATTG/TTTCTG 2 -- us2k1 ds50010--------
    rs1862833431,2
    		--31585842(+) AGATAA/GCCTCA 2 -- ds5001 us2k10--------
    rs169862431,2
    		C,F,H,--31585884(+) TCATAA/CAAGAT 2 -- ds5001 us2k110Minor allele frequency- C:0.10NA NS EA WA 678
    rs1389209891,2
    		--31585928(+) AGCATA/GTAATA 2 -- ds5001 us2k10--------
    rs1121067871,2
    		--31585949(+) GAACAT/CTAGAC 2 -- ds5001 us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1915543641,2
    		--31585954(+) TTAGAA/CAATAT 2 -- ds5001 us2k10--------
    rs1429446371,2
    		--31585972(+) TATTTA/CTCAGA 2 -- us2k1 ds50010--------
    rs1473929721,2
    		--31586005(+) CAGAAA/CATTTT 2 -- us2k1 ds50010--------
    rs1834187591,2
    		--31586028(+) GTTATA/GTACAT 2 -- ds5001 us2k10--------
    rs561282691,2
    		C,--31586032(+) TATACA/GTAATA 2 -- us2k1 ds50014Minor allele frequency- G:0.14WA NA EA 360

    HapMap Linkage Disequilibrium report for CLDN8 (31586324 - 31588469 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLDN8: --

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    Disorders / Diseases
    for CLDN8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLDN8 for disorders           About GeneDecksing

    OMIM gene information: 611231    OMIM disorders: --

    16 diseases for CLDN8:    About MalaCards
    chromophobe renal cell carcinoma    renal oncocytoma    renal cell carcinoma    carcinoma
    pseudohypoaldosteronism type i    oxyphilic adenoma    pseudohypoaldosteronism    ulcerative colitis
    down syndrome    hepatitis c    epididymitis    crohn's disease
    adenoma    gastric cancer    colorectal cancer    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for CLDN8:
    Renal oncocytoma     Oxyphilic adenoma

    2 Novoseek disease relationships for CLDN8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 58.3 8 18799195 (5), 19302533 (1), 18587324 (1)
    tumors 0 5 18799195 (2), 17922590 (1)


    Export disorders for CLDN8 gene to outside databases

    Publications
    for CLDN8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN8 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with CLDN8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    4. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (1999)
    5. Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. (PubMed id 18799195)1, 9 Osunkoya A.O....Young A.N. (2009)
    6. Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation. (PubMed id 19000657)1, 9 Amasheh S....Fromm M. (2009)
    7. Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12. (PubMed id 17047970)1, 9 Grone J....Buhr H.J. (2007)
    8. Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma. (PubMed id 19302533)1, 9 Kim S.S....Choi C. (2009)
    9. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)1, 9 Hu Y.H....Janitz M. (2006)
    10. Antibody-based protein profiling of the human chromosome 21. (PubMed id 22042635)2 Uhlen M....Sivertsson A. (2012)

    External Searches for CLDN8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CLDN8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9073 HGNC: 2050 AceView: CLDN8 Ensembl:ENSG00000156284 euGenes: HUgn9073
    ECgene: CLDN8 Kegg: 9073 H-InvDB: CLDN8

    Other Databases showing CLDN8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLDN8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLDN8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLDN8 gene:
    Search GeneIP for patents involving CLDN8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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