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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN8 Gene

protein-coding   GIFtS: 61
GCID: GC21M031586

Claudin 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Claudin 81 2
Human CLDN8 Gene For Claudin-811
claudin-82

External Ids:    HGNC: 20501   Entrez Gene: 90732   Ensembl: ENSG000001562847   OMIM: 6112315   UniProtKB: P567483   

Export aliases for CLDN8 gene to outside databases

Previous GC identifers: GC21M028163 GC21M028246 GC21M030507 GC21M030508 GC21M030509 GC21M016995


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLDN8 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular
cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in
distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell
tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe
renal cell carcinoma and renal oncocytoma.(provided by RefSeq, May 2010)

GeneCards Summary for CLDN8 Gene: 
CLDN8 (claudin 8) is a protein-coding gene. Diseases associated with CLDN8 include oxyphilic adenoma, and renal oncocytoma, and among its related super-pathways are Cell-cell junction organization and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is CLDN4.

UniProtKB/Swiss-Prot: CLD8_HUMAN, P56748
Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

Gene Wiki entry for CLDN8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN8 gene promoter:
         STAT1   STAT4   STAT6   STAT1beta   STAT5A   CUTL1   STAT1alpha   GATA-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN8 promoter sequence

   Search SABiosciences Chromatin IP Primers for CLDN8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.11
CLDN8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN8 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M031586:   GeneLoc Nature:405,311-319
Start:
31,586,324 bp from pter       17,163,042 bp from centromere
End:
31,588,469 bp from pter 17,164,972 bp from centromere
Size:
2,146 bases 1,931 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AJ250711
genomic clones: R463J19


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLD8_HUMAN, P56748 (See protein sequence)
Recommended Name: Claudin-8  
Size: 225 amino acids; 24845 Da
Subunit: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity)
Subcellular location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to
tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal
cells, and in the corpus at the interface between basal and principal cells
Miscellaneous: A protein of the expected size has been detected by antibody binding and Western blot in at least
one of the analyzed tissues or cells (PubMed:22042635)
Secondary accessions: D3DSE3 Q53EX7

Explore the universe of human proteins at neXtProt for CLDN8: NX_P56748

Explore proteomics data for CLDN8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P56748

  • CLDN8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLDN8 Protein Expression
    REFSEQ proteins: NP_955360.1  
    ENSEMBL proteins: 
     ENSP00000382783   ENSP00000286809  
    Reactome Protein details: P56748
    Human Recombinant Protein Products for CLDN8: 
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    Cloud-Clone Corp. Proteins for CLDN8 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA16780588
    GO:0005886plasma membrane IDA16780588
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane IEA--

    CLDN8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR003926 Claudin8
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry P56748

    ProtoNet protein and cluster: P56748

    2 Blocks protein domains:
    IPB003926 Claudin-8 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD8_HUMAN, P56748
    Similarity: Belongs to the claudin family


    CLDN8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD8_HUMAN, P56748
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

         Genatlas biochemistry entry for CLDN8:
    claudin 8,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major
    structural components of tight junction (TJ) strands,potentially developmentally regulated

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding ISS--
         
    CLDN8 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Cldn8 (no phenotypes)

    CLDN8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cldn8tm1Lex for CLDN8

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLDN8 
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    SwitchGear 3'UTR luciferase reporter plasmidCLDN8 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLDN8 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell-cell junction organization0.69
    Cell-Cell communication0.64
    Cell junction organization0.69
    Tight junction interactions0.49
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    5Tight junction
    Tight junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CLDN8
        Cell adhesion Tight junctions

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN8
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN8
        Cell adhesion Tight junctions

    4        Reactome Pathways for CLDN8
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN8):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/25 Interacting proteins for CLDN8 (P567483 ENSP000002868094) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    CLDN1ENSP000002955224STRING: ENSP00000295522
    CLDN10ENSP000002993394STRING: ENSP00000299339
    CLDN11ENSP000000647244STRING: ENSP00000064724
    CLDN14ENSP000003392924STRING: ENSP00000339292
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--

    CLDN8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN8 (CLD8)

    Search CenterWatch for drugs/clinical trials and news about CLDN8 / CLD8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLDN8 gene (2 alternative transcripts): 
    NM_199328.2  NM_012132.3  

    Unigene Cluster for CLDN8:

    Claudin 8
    Hs.162209  [show with all ESTs]
    Unigene Representative Sequence: NM_199328
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399899(uc002ynu.2) ENST00000286809
    miRNA
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN8 (see all 20):
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    SwitchGear 3'UTR luciferase reporter plasmidCLDN8 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK022269.1 AK223512.1 AL049977.1 AY358707.1 BC058004.1 

    2 DOTS entries:

    DT.101971566  DT.101980373 

    24/31 AceView cDNA sequences (see all 31):

    AW237740 BF196092 AY358707 CB851106 BC058004 AW237781 AW205135 BX283446 
    BF195920 BC020866 NM_199328 BE000282 BG674625 BG402103 BG426438 BV199182 
    AU121779 AA769736 AW235670 AL049977 AK022269 AA536178 AU147533 BE172635 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN8 expression in normal human tissues (normalized intensities)      CLDN8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATAGGGTTG
    CLDN8 Expression
    About this image


    CLDN8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Kidney (Urinary System)    fully expand to see all 11 entries
             Loop of Henle Cells Loop of Henle
             Metanephros
             visceral organ/metanephros/calyx   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 6 entries
             Ureter
             visceral organ   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/nasal cavity   
     
     Bone (Muscoskeletal System)
             sensory organ/ear/inner ear   

    See CLDN8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN8

    SOURCE GeneReport for Unigene cluster: Hs.162209

    UniProtKB/Swiss-Prot: CLD8_HUMAN, P56748
    Tissue specificity: Expressed in the epididymis, mainly in the caput segment

        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN8: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN8 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn81 , 5 claudin 81, 5 82.96(n)1
    82.67(a)1
      16 (51.22 cM)5
    544201  NM_018778.31  NP_061248.11 
     885608285 
    chicken
    (Gallus gallus)
    Aves CLDN81 claudin 8 68.3(n)
    65.18(a)
      427974  XM_425544.2  XP_425544.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLDN86
    Uncharacterized protein
    59(a)
    1 ↔ 1
    3(146053769-146055592)
    zebrafish
    (Danio rerio)
    Actinopterygii cldn81 claudin 8 58.21(n)
    53.3(a)
      445278  NM_001003733.1  NP_001003733.1 


    ENSEMBL Gene Tree for CLDN8 (if available)
    TreeFam Gene Tree for CLDN8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN8 gene
    CLDN42  CLDN92  CLDN202  CLDN172  CLDN52  CLDN102  CLDN22  CLDN152  
    CLDN12  CLDN32  CLDN142  CLDN62  CLDN72  CLDN192  
    18 SIMAP similar genes for CLDN8 using alignment to 1 protein entry:     CLD8_HUMAN:
    CLDN17    CLDN4    CLDN7    CLDN9    CLDN19    CLDN5
    CLDN6    CLDN1    CLDN3    CLDN2    CLDN14    CLDN24
    CLDN22    CLDN18    CLDN20    CLDN10    CLDN25    CLDN15

    CLDN8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/121 SNPs in CLDN8 are shown (see all 121)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862554921,2
    --31586245(+) TTGGAC/GAATAA 1 -- ds50010--------
    rs1913008931,2
    --31586247(+) GGAGAA/GTAAAA 1 -- ds50010--------
    rs134335071,2
    C,F,H--31586370(+) ATAAAG/ACAAAT 1 -- ut3111Minor allele frequency- A:0.08NS EA NA WA 860
    rs1822500921,2
    --31586485(+) TTTAGA/TAAAAC 1 -- ut310--------
    rs733435741,2
    C--31586571(+) AGGAGC/TAGGTG 1 -- ut312Minor allele frequency- T:0.04WA 120
    rs1131295871,2
    C,F--31586715(+) CCATAC/TATATA 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1864854211,2
    --31586722(+) TATATG/TATTTC 1 -- ut310--------
    rs1908997481,2
    C--31586816(+) ACTTTC/TATCTT 1 -- ut310--------
    rs1414516621,2
    C--31586896(+) AATGTC/TAATTT 1 -- ut310--------
    rs1389415031,2
    C--31587191(+) CATAT-/AAGCAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLDN8 (31586324 - 31588469 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CLDN8: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLDN8
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611231    OMIM disorders: --

    15 diseases for CLDN8:    About MalaCards
    oxyphilic adenoma    renal oncocytoma    chromophobe renal cell carcinoma    renal cell carcinoma
    pseudohypoaldosteronism    ulcerative colitis    epididymitis    crohn's disease
    down syndrome    endotheliitis    hepatitis c    adenoma
    gastric cancer    colorectal cancer    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for CLDN8:
    Oxyphilic adenoma     Renal oncocytoma

    CLDN8 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CLDN8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 58.3 8 18799195 (5), 19302533 (1), 18587324 (1)
    tumors 0 5 18799195 (2), 17922590 (1)

    Genetic Association Database (GAD): CLDN8

    Export disorders for CLDN8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN8 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with CLDN8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    4. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (1999)
    5. Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. (PubMed id 18799195)1, 9 Osunkoya A.O....Young A.N. (2009)
    6. Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation. (PubMed id 19000657)1, 9 Amasheh S....Fromm M. (2009)
    7. Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12. (PubMed id 17047970)1, 9 Grone J....Buhr H.J. (2007)
    8. Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma. (PubMed id 19302533)1, 9 Kim S.S....Choi C. (2009)
    9. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)1, 9 Hu Y.H....Janitz M. (2006)
    10. Human claudin-8 and -14 are receptors capable of conve ying the cytotoxic effects of Clostridium perfringens enterotoxin. (PubMed id 23322640)1 Shrestha A. and McClane B.A. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9073 HGNC: 2050 AceView: CLDN8 Ensembl:ENSG00000156284 euGenes: HUgn9073
    ECgene: CLDN8 Kegg: 9073 H-InvDB: CLDN8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLDN8 gene:
    Search GeneIP for patents involving CLDN8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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