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Aliases for CLDN8 Gene

Aliases for CLDN8 Gene

  • Claudin 8 2 3 5
  • Epididymis Secretory Protein Li 79 3
  • Claudin-8 3
  • HEL-S-79 3

External Ids for CLDN8 Gene

Previous GeneCards Identifiers for CLDN8 Gene

  • GC21M028163
  • GC21M028246
  • GC21M030507
  • GC21M030508
  • GC21M030509
  • GC21M031586
  • GC21M016995

Summaries for CLDN8 Gene

Entrez Gene Summary for CLDN8 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]

GeneCards Summary for CLDN8 Gene

CLDN8 (Claudin 8) is a Protein Coding gene. Diseases associated with CLDN8 include Renal Oncocytoma and Chromophobe Renal Cell Carcinoma. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN17.

UniProtKB/Swiss-Prot for CLDN8 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space.

Gene Wiki entry for CLDN8 Gene

Additional gene information for CLDN8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN8 Gene

Genomics for CLDN8 Gene

Regulatory Elements for CLDN8 Gene

Enhancers for CLDN8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21H030226 1.1 Ensembl ENCODE 7.8 -11.6 -11555 2.1 HDAC1 TBL1XR1 TCF12 GATA2 FOS CEBPB NCOA1 NR2F2 NFIC SMARCA4 CLDN8 GC21M030264
GH21H030233 0.4 ENCODE 7.7 -18.3 -18262 2.4 CEBPG LINC00307 KRTAP24-1 KRTAP25-1 CLDN17 CLDN8 GC21M030264
GH21H030271 0.2 ENCODE 7.6 -55.6 -55551 1.3 CLDN8 RPL8P2 KRTAP24-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLDN8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CLDN8 Gene

Genomic Locations for CLDN8 Gene
2,146 bases
Minus strand

Genomic View for CLDN8 Gene

Genes around CLDN8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN8 Gene

Proteins for CLDN8 Gene

  • Protein details for CLDN8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DSE3
    • Q53EX7

    Protein attributes for CLDN8 Gene

    225 amino acids
    Molecular mass:
    24845 Da
    Quaternary structure:
    • Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
    • A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.

neXtProt entry for CLDN8 Gene

Post-translational modifications for CLDN8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN8 Gene

Domains & Families for CLDN8 Gene

Gene Families for CLDN8 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for CLDN8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the claudin family.
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN8: view

Function for CLDN8 Gene

Molecular function for CLDN8 Gene

GENATLAS Biochemistry:
claudin 8,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands,potentially developmentally regulated
UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space.

Gene Ontology (GO) - Molecular Function for CLDN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN8: view
genes like me logo Genes that share phenotypes with CLDN8: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN8 Gene

Localization for CLDN8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN8 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN8 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CLDN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16780588
GO:0005886 plasma membrane IDA 16780588
GO:0005923 bicellular tight junction ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLDN8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLDN8 Gene

Pathways & Interactions for CLDN8 Gene

genes like me logo Genes that share pathways with CLDN8: view

Gene Ontology (GO) - Biological Process for CLDN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
genes like me logo Genes that share ontologies with CLDN8: view

No data available for SIGNOR curated interactions for CLDN8 Gene

Drugs & Compounds for CLDN8 Gene

No Compound Related Data Available

Transcripts for CLDN8 Gene

mRNA/cDNA for CLDN8 Gene

Unigene Clusters for CLDN8 Gene

Claudin 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN8 Gene

No ASD Table

Relevant External Links for CLDN8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLDN8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLDN8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN8 Gene

This gene is overexpressed in Minor Salivary Gland (x8.3), Colon - Transverse (x8.3), Breast - Mammary Tissue (x7.4), Kidney - Cortex (x6.9), and Vagina (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of CLDN8 Gene:


SOURCE GeneReport for Unigene cluster for CLDN8 Gene:


mRNA Expression by UniProt/SwissProt for CLDN8 Gene:

Tissue specificity: Expressed in the epididymis, mainly in the caput segment.

Evidence on tissue expression from TISSUES for CLDN8 Gene

  • Kidney(4.6)
  • Intestine(4.5)
genes like me logo Genes that share expression patterns with CLDN8: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN8 Gene

Orthologs for CLDN8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLDN8 33 34
  • 99.7 (n)
(Bos Taurus)
Mammalia CLDN8 33 34
  • 86.67 (n)
(Canis familiaris)
Mammalia CLDN8 33 34
  • 86.37 (n)
(Rattus norvegicus)
Mammalia Cldn8 33
  • 83.26 (n)
(Mus musculus)
Mammalia Cldn8 33 16 34
  • 82.96 (n)
(Monodelphis domestica)
Mammalia CLDN8 34
  • 82 (a)
(Gallus gallus)
Aves CLDN8 33 34
  • 68.45 (n)
(Anolis carolinensis)
Reptilia CLDN8 34
  • 59 (a)
(Danio rerio)
Actinopterygii zgc:110333 33
  • 57.87 (n)
CLDN17 34
  • 30 (a)
Species where no ortholog for CLDN8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN8 Gene

Gene Tree for CLDN8 (if available)
Gene Tree for CLDN8 (if available)

Paralogs for CLDN8 Gene

Paralogs for CLDN8 Gene

(18) SIMAP similar genes for CLDN8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLDN8: view

Variants for CLDN8 Gene

Sequence variations from dbSNP and Humsavar for CLDN8 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs370704016 Uncertain significance 30,215,568(+) CGTCA(A/G)CAGAA reference, synonymous-codon
rs387907424 Uncertain significance 30,215,764(-) AATTG(A/C)GTGAG reference, stop-gained
rs1000108779 -- 30,214,467(+) TTCCT(A/G)AAACC utr-variant-3-prime
rs1000311791 -- 30,216,133(+) CTGCA(A/G)CAGGT utr-variant-5-prime
rs1000688416 -- 30,216,327(+) CATAA(C/G)CATCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLDN8 Gene

Variant ID Type Subtype PubMed ID
nsv587354 CNV gain 21841781
nsv587355 CNV loss 21841781

Variation tolerance for CLDN8 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.52; 91.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLDN8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN8 Gene

Disorders for CLDN8 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CLDN8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal oncocytoma
  • oncocytoma of kidney
chromophobe renal cell carcinoma
  • chromophobe adenocarcinoma
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
pseudohypoaldosteronism, type i
  • pseudohypoaldosteronism
- elite association - COSMIC cancer census association via MalaCards
Search CLDN8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLDN8

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CLDN8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN8 Gene

Publications for CLDN8 Gene

  1. Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. (PMID: 18799195) Osunkoya AO … Young AN (Human pathology 2009) 3 22 60
  2. Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation. (PMID: 19000657) Amasheh S … Fromm M (Biochemical and biophysical research communications 2009) 3 22 60
  3. Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma. (PMID: 19302533) Kim SS … Choi C (Histopathology 2009) 3 22 60
  4. Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12. (PMID: 17047970) Gröne J … Buhr HJ (International journal of colorectal disease 2007) 3 22 60
  5. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PMID: 16780588) Hu YH … Janitz M (BMC genomics 2006) 3 22 60

Products for CLDN8 Gene

Sources for CLDN8 Gene

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