External Ids for CLDN8 Gene
Previous GeneCards Identifiers for CLDN8 Gene
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]
GeneCards Summary for CLDN8 Gene
CLDN8 (Claudin 8) is a Protein Coding gene. Diseases associated with CLDN8 include Renal Oncocytoma and Chromophobe Renal Cell Carcinoma. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN17.
UniProtKB/Swiss-Prot for CLDN8 Gene
Plays a major role in tight junction-specific obliteration of the intercellular space.