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Aliases for CLDN7 Gene

Aliases for CLDN7 Gene

  • Claudin 7 2 3 5
  • CEPTRL2 3 4
  • CPETRL2 3 4
  • CLDN-7 3 4
  • Clostridium Perfringens Enterotoxin Receptor-Like 2 3
  • Claudin-1 3
  • Claudin-7 3
  • Hs.84359 3

External Ids for CLDN7 Gene

Previous HGNC Symbols for CLDN7 Gene


Previous GeneCards Identifiers for CLDN7 Gene

  • GC17M007585
  • GC17M007893
  • GC17M007106
  • GC17M007364
  • GC17M007104
  • GC17M007103
  • GC17M007163
  • GC17M007054

Summaries for CLDN7 Gene

Entrez Gene Summary for CLDN7 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

GeneCards Summary for CLDN7 Gene

CLDN7 (Claudin 7) is a Protein Coding gene. Diseases associated with CLDN7 include Ductal Carcinoma In Situ and Chromophobe Renal Cell Carcinoma. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN1.

UniProtKB/Swiss-Prot for CLDN7 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space.

Gene Wiki entry for CLDN7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN7 Gene

Genomics for CLDN7 Gene

Regulatory Elements for CLDN7 Gene

Enhancers for CLDN7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F007233 1.2 ENCODE 23 +25.3 25303 11.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 DVL2 CNTROB SNORD10 SNORA48 KIAA0753 ELP5 SENP3 MIR6883 NEURL4 ZBTB4
GH17F007256 1.1 ENCODE 24.4 +3.2 3186 8.7 HDGF ARNT MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS ELP5 YBX2 CLDN7 GABARAP SLC2A4 DLG4 PIR33341 ENSG00000262302
GH17F007213 1.4 FANTOM5 ENCODE 17.8 +45.3 45294 10.6 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 ELP5 CLDN7 SENP3 ZBTB4 LOC100996842 NEURL4 DVL2 MIR6883 KIAA0753 MIR324
GH17F007203 1.2 Ensembl ENCODE 14.5 +57.6 57570 5.7 HDGF PKNOX1 ATF1 WRNIP1 ZFP64 SIN3A YBX1 ZNF48 YY1 GLIS2 ELP5 CLDN7 DVL2 CNTROB SNORD10 DLG4 YBX2 NLGN2 EIF5A ENSG00000279812
GH17F007167 1.2 Ensembl ENCODE 10.6 +92.2 92233 8.0 ZNF133 NFXL1 YBX1 GLI4 RAD21 YY1 ZNF354C ZNF207 KLF7 ZNF548 DVL2 SNORD10 CNTROB SNORA48 MIR324 MIR6883 CYB5D1 SLC16A11 KCTD11 ACADVL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLDN7 on UCSC Golden Path with GeneCards custom track

Promoters for CLDN7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CLDN7 Gene

7,259,903 bp from pter
7,263,983 bp from pter
4,081 bases
Minus strand

Genomic View for CLDN7 Gene

Genes around CLDN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN7 Gene

Proteins for CLDN7 Gene

  • Protein details for CLDN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R9X7
    • D3DTP0
    • Q6IPN3
    • Q7Z4Y7
    • Q9BVN0

    Protein attributes for CLDN7 Gene

    211 amino acids
    Molecular mass:
    22418 Da
    Quaternary structure:
    • Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts with EPCAM.
    • Sequence=AAP97219.1; Type=Frameshift; Positions=18, 23; Evidence={ECO:0000305};

    Alternative splice isoforms for CLDN7 Gene


neXtProt entry for CLDN7 Gene

Post-translational modifications for CLDN7 Gene

No data available for DME Specific Peptides for CLDN7 Gene

Domains & Families for CLDN7 Gene

Gene Families for CLDN7 Gene

Suggested Antigen Peptide Sequences for CLDN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the claudin family.
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN7: view

Function for CLDN7 Gene

Molecular function for CLDN7 Gene

GENATLAS Biochemistry:
claudin 7,clostridium perfringens enterotoxin receptor-like 2,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands,primarly expressed in lung and kidney
UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space.
UniProtKB/Swiss-Prot Induction:
By androgens.

Gene Ontology (GO) - Molecular Function for CLDN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 16054130
GO:0042802 identical protein binding ISS --
GO:0050839 cell adhesion molecule binding IEA --
genes like me logo Genes that share ontologies with CLDN7: view
genes like me logo Genes that share phenotypes with CLDN7: view

Animal Models for CLDN7 Gene

MGI Knock Outs for CLDN7:

Animal Model Products

miRNA for CLDN7 Gene

miRTarBase miRNAs that target CLDN7

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CLDN7

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLDN7 Gene

Localization for CLDN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN7 Gene

Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction, tight junction. Note=Co-localizes with EPCAM at the lateral cell membrane and tight junction.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN7 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CLDN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with CLDN7: view

Pathways & Interactions for CLDN7 Gene

genes like me logo Genes that share pathways with CLDN7: view

Gene Ontology (GO) - Biological Process for CLDN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
GO:0032463 negative regulation of protein homooligomerization IEA --
GO:0043066 negative regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with CLDN7: view

No data available for SIGNOR curated interactions for CLDN7 Gene

Drugs & Compounds for CLDN7 Gene

(1) Additional Compounds for CLDN7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLDN7: view

Transcripts for CLDN7 Gene

Unigene Clusters for CLDN7 Gene

Claudin 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CLDN7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1: - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for CLDN7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLDN7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLDN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN7 Gene

This gene is overexpressed in Colon - Transverse (x13.2), Esophagus - Mucosa (x8.7), Small Intestine - Terminal Ileum (x5.1), and Minor Salivary Gland (x4.9).

Protein differential expression in normal tissues from HIPED for CLDN7 Gene

This gene is overexpressed in Oral epithelium (14.8), Salivary gland (11.2), Stomach (7.1), Islet of Langerhans (6.4), and Tonsil (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CLDN7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CLDN7 Gene:


SOURCE GeneReport for Unigene cluster for CLDN7 Gene:


mRNA Expression by UniProt/SwissProt for CLDN7 Gene:

Tissue specificity: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
genes like me logo Genes that share expression patterns with CLDN7: view

No data available for Protein tissue co-expression partners for CLDN7 Gene

Orthologs for CLDN7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLDN7 34 35
  • 99.53 (n)
(Bos Taurus)
Mammalia CLDN7 34 35
  • 89.89 (n)
(Canis familiaris)
Mammalia CLDN7 34 35
  • 89.57 (n)
(Mus musculus)
Mammalia Cldn7 34 16 35
  • 87.84 (n)
(Rattus norvegicus)
Mammalia Cldn7 34
  • 86.89 (n)
(Monodelphis domestica)
Mammalia CLDN7 35
  • 86 (a)
(Danio rerio)
Actinopterygii cldn7b 34 35
  • 58.93 (n)
cldn7a 35
  • 56 (a)
Species where no ortholog for CLDN7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN7 Gene

Gene Tree for CLDN7 (if available)
Gene Tree for CLDN7 (if available)

Paralogs for CLDN7 Gene Pseudogenes for CLDN7 Gene

genes like me logo Genes that share paralogs with CLDN7: view

Variants for CLDN7 Gene

Sequence variations from dbSNP and Humsavar for CLDN7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1050097 -- 7,259,753(+) TCTTT(C/T)TATTG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111255205 -- 7,260,993(+) GCGGG(C/G/T)GAGGG intron-variant
rs111956205 -- 7,265,128(+) TTTTT(A/T)TTTTT upstream-variant-2KB
rs112216779 -- 7,263,615(+) TTTTT(G/T)GTTGT upstream-variant-2KB
rs112566076 -- 7,261,180(+) CCTTC(C/T)TGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLDN7 Gene

Variant ID Type Subtype PubMed ID
dgv885e212 CNV loss 25503493
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv3639861 CNV loss 21293372
nsv1963 CNV deletion 18451855
nsv457659 CNV loss 19166990
nsv480494 CNV novel sequence insertion 20440878
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for CLDN7 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLDN7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN7 Gene

Disorders for CLDN7 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CLDN7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ductal carcinoma in situ
  • noninfiltrating intraductal carcinoma
chromophobe renal cell carcinoma
  • chromophobe adenocarcinoma
prostate transitional cell carcinoma
  • transitional cell carcinoma of prostate
gastric adenocarcinoma
  • adenocarcinoma of stomach
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search CLDN7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLDN7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CLDN7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN7 Gene

Publications for CLDN7 Gene

  1. The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7. (PMID: 16054130) Ladwein M. … Zoeller M. (Exp. Cell Res. 2005) 3 4 22 64
  2. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. (PMID: 12673207) Kominsky S.L. … Sukumar S. (Oncogene 2003) 3 4 22 64
  3. Regulation of the expression of the prostate-specific antigen by claudin-7. (PMID: 14502431) Zheng J.-Y. … Pang S. (J. Membr. Biol. 2003) 3 4 22 64
  4. Distribution and expression pattern of claudins 6, 7, and 9 in diffuse- and intestinal-type gastric adenocarcinomas. (PMID: 19960275) RendA^n-Huerta E. … MontaA+o L.F. (J Gastrointest Cancer 2010) 3 22 64
  5. Expression pattern of claudins 5 and 7 distinguishes solid-pseudopapillary from pancreatoblastoma, acinar cell and endocrine tumors of the pancreas. (PMID: 19194274) Comper F. … Scarpa A. (Am. J. Surg. Pathol. 2009) 3 22 64

Products for CLDN7 Gene

Sources for CLDN7 Gene

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