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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN7 Gene

protein-coding   GIFtS: 64
GCID: GC17M007163

claudin 7


(Previous symbols: CEPTRL2, CPETRL2)
 Explore 50 diseases affiliated with
CLDN7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLDN7    

Aliases
for CLDN7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Claudin 71 2     Claudin-11
CEPTRL21 2 3     Claudin-71
CPETRL21 2 3     Clostridium Perfringens Enterotoxin Receptor-Like 22
CLDN-72 3     

External Ids:    HGNC: 20491   Entrez Gene: 13662   Ensembl: ENSG000001818857   OMIM: 6091315   UniProtKB: O954713   

Export aliases for CLDN7 gene to outside databases

Previous GC identifers: GC17M007585 GC17M007893 GC17M007106 GC17M007364 GC17M007104 GC17M007103 GC17M007054


Summaries
for CLDN7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLDN7:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely
through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in
maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in
different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors,
prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript
variants encoding different isoforms have been found.(provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: CLD7_HUMAN, O95471
Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

Gene Wiki entry for CLDN7


Genomic Views
for CLDN7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN7 gene promoter:
         MEF-2A   PPAR-gamma1   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLDN7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLDN7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  17p13.1   HGNC chromosome: 17

CLDN7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007163:  view genomic region     (about GC identifiers)

Start:
 7,163,222 bp from pter      End:
 7,167,302 bp from pter
Size:
 4,081 bases      Orientation:
 minus strand

Proteins
for CLDN7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLD7_HUMAN, O95471 (See protein sequence)
Recommended Name: Claudin-7  
Size: 211 amino acids; 22418 Da
Subunit: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts
with EPCAM
Subcellular location: Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction, tight junction.
Note=Co-localizes with EPCAM at the lateral cell membrane and tight junction
Sequence caution: Sequence=AAP97219.1; Type=Frameshift; Positions=18, 23;
Secondary accessions: B2R9X7 D3DTP0 Q6IPN3 Q7Z4Y7 Q9BVN0
Alternative splicing: 2 isoforms:  O95471-1   O95471-2   

Explore the universe of human proteins at neXtProt for CLDN7: NX_O95471

Post-translational modifications:

  • Phosphorylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95471

    • CLDN7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171951.1  NP_001171952.1  NP_001298.3  

    ENSEMBL proteins: 
     ENSP00000353475   ENSP00000445131   ENSP00000396638   ENSP00000460550   ENSP00000460796  
     ENSP00000465963   ENSP00000467220  
    Reactome Protein details: O95471
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): CLDN7
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    Novus Biologicals CLDN7 Proteins
    Novus Biologicals CLDN7 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLDN7

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane IEA--
    GO:0016328lateral plasma membrane IEA--


    CLDN7 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLDN7

    Protein Domains /
    Families
    for CLDN7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLDN7 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017974 Claudin_CS
     IPR003552 Claudin7
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry O95471

    ProtoNet protein and cluster: O95471

    2 Blocks protein families:
    IPB003552 Claudin-7 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD7_HUMAN, O95471
    Similarity: Belongs to the claudin family


    Function
    for CLDN7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLD7_HUMAN, O95471
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)
    Induction: By androgens

         Genatlas biochemistry entry for CLDN7:
    claudin 7,clostridium perfringens enterotoxin receptor-like 2,integral membrane protein,claudin family of major
    structural components of tight junction (TJ) strands,primarly expressed in lung and kidney

    miRNA
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    hsa-miR-1183 hsa-miR-3148 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN7 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding IPI16054130
    GO:0042802identical protein binding ISS--


    CLDN7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CLDN7:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Cldn7tm1Yche for CLDN7
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cldn7):
     growth/size  hematopoietic system  homeostasis/metabolism  integument  mortality/aging 
     renal/urinary system 

    CLDN7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLDN7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Tight junction interactions0.49
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99
    3Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Epithelial Tight Junctions0.36
    4Hepatitis C
    		Hepatitis C1.00
    5Leukocyte transendothelial migration
    		Leukocyte transendothelial migration1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CLDN7
        Cell adhesion Tight junctions

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN7
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN7
        Cell adhesion Tight junctions

    4        Reactome Pathways for CLDN7
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN7):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLDN7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for CLDN7 (O954712, 3 ENSP000003534754) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOXF2Q9BQY42, 3, ENSP000003604414MINT-66102 I2D: score=5 STRING: ENSP00000360441
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    CLDN3O155513, ENSP000003785774I2D: score=1 STRING: ENSP00000378577
    EPCAMP164223, ENSP000002637354I2D: score=1 STRING: ENSP00000263735
    RBPMSQ930623I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--


    CLDN7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLDN7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLDN7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CLDN7
    1 Novoseek chemical compound relationship for CLDN7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 19.9 2 18799195 (1), 18784823 (1)

    Search CenterWatch for drugs/clinical trials and news about CLDN7 / CLD7 

    Transcripts
    for CLDN7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLDN7 gene (3 alternative transcripts): 
    NM_001185022.1  NM_001185023.1  NM_001307.5  

    Unigene Cluster for CLDN7:

    Claudin 7
    Hs.513915  [show with all ESTs]
    Unigene Representative Sequence: NM_001307
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360325(uc002gfm.4 uc010cmc.3 uc002gfn.4) ENST00000538261
    ENST00000397317 ENST00000574070 ENST00000575313 ENST00000571881 ENST00000571932
    ENST00000573745

    miRNA
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    hsa-miR-1183 hsa-miR-3148 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN7 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN7 (see all 7)
    OriGene shRNA RFP: CLDN7
    OriGene siRNA: CLDN7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN7
    Clone
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    Additional cDNA sequence: 

    AF093823.1 AJ011497.1 AK225418.1 AK313958.1 BC001055.2 BC071844.1 BT006829.1 

    17 DOTS entries:

    DT.120063  DT.95227264  DT.100028964  DT.100037238  DT.99929252  DT.120968552  DT.120968623  DT.120968695 
    DT.100791266  DT.120968459  DT.92400449  DT.95187930  DT.120968791  DT.95160031  DT.120968749  DT.92427696 
    DT.120968475 

    24/672 AceView cDNA sequences (see all 672):

    BG056404 AI338574 AI816986 BG746404 AI474511 W79938 BQ901179 BU956095 
    BF844591 AI815068 BQ643517 BM818900 CD675069 NM_007278 AI365977 BU856629 
    AA774393 H45728 BU169292 AW161008 AI830091 CN484963 F15724 BE465583 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLDN7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
    SP1:              -     -                       -                                 
    SP2:                                            -                                 
    SP3:                                      -     -                                 
    SP4:                    -                                                         
    SP5:                                                                              


    ECgene alternative splicing isoforms for CLDN7

    Expression
    for CLDN7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATAGTCCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLDN7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    KidneyUreteric BudUreteric Bud CellsKidney
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    OvaryOvigerous CordOvarian Somatic CellsOvary
    TestisSeminiferous TubulesSertoli cellsTestis
    Gut TubeHindgutGut Tube
    Gut TubeMidgutGut Tube
    KidneyRenal Collecting Duct SystemKidney
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

    See CLDN7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN7

    SOURCE GeneReport for Unigene cluster: Hs.513915

    UniProtKB/Swiss-Prot: CLD7_HUMAN, O95471
    Tissue specificity: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal
    prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in
    situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in
    several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in
    high-grade lesions

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    In Situ
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    Orthologs
    for CLDN7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN7 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii cldn7b1 claudin 7b 58.93(n)
    61.14(a)    		   60635  NM_131637.1  NP_571712.1 


    ENSEMBL Gene Tree for CLDN7 (if available)
    TreeFam Gene Tree for CLDN7 (if available) 

    Paralogs
    for CLDN7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN7 gene
    CLDN92  CLDN42  CLDN82  CLDN202  CLDN172  CLDN52  CLDN22  CLDN102  
    CLDN152  CLDN32  CLDN142  CLDN12  CLDN62  CLDN192  
    18/19 SIMAP similar genes for CLDN7 using alignment to 6 protein entries:     CLD7_HUMAN (see all proteins) (see all similar genes):
    CLDN1    CLDN19    CLDN4    CLDN9    CLDN3    CLDN6
    CLDN10    CLDN2    CLDN8    CLDN14    CLDN5    CLDN17
    CLDN20    CLDN15    CLDN18    CLDN24    CLDN22    CLDN11

    CLDN7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLDN7
    PGOHUM00000241243


    Genomic Variants
    for CLDN7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/108 NCBI SNPs in CLDN7 are shown (see all 108)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1822550271,2
    		--7162788(+) ATGGAA/GGCCTA 7 -- ds5001 int1 ut310--------
    rs2019107081,2
    		--7163043(+) GGCGCA/GGGAAG 7 -- ut31 ds50010--------
    rs790334551,2
    		C,F,--7163200(+) GTAATG/ATGAGA 7 -- ut31 ds50011Minor allele frequency- A:0.24EA 120
    rs1432380641,2
    		--7163214(+) TAGAAC/TACCCC 7 -- ut31 ds50010--------
    rs1852690041,2
    		--7163312(+) AGATAC/TGAGCA 7 -- int1 ut310--------
    rs12151,2
    		C,F,H,--7163350(+) GAGTCA/GGTGGG 7 -- ut31 int1 ese316Minor allele frequency- G:0.16MN NS EA NA 2484
    rs782963671,2
    		--7163434(+) GCAGAC/GGCCCT 7 -- int1 ut310--------
    rs1390562641,2
    		C,--7163666(+) AGCCTC/GTCAGG 7 -- int1 ut310--------
    rs1507338091,2
    		C--7163702(+) ACATAC/ATCCTT 9 /E /D int1 mis1 ut311Minor allele frequency- A:0.00NA 4548
    rs1390880431,2
    		C,F,--7163713(+) GGAAGA/GGTTGG 9 P S int1 ut31 mis11Minor allele frequency- G:0.00NA 4552

    HapMap Linkage Disequilibrium report for CLDN7 (7163222 - 7167302 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLDN7: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN7
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN7

    Disorders / Diseases
    for CLDN7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLDN7 for disorders           About GeneDecksing

    OMIM gene information: 609131    OMIM disorders: --

    20/50 diseases for CLDN7 (see all 50):    About MalaCards
    hepatocellular carcinoma    carcinoma    thyroid carcinoma    ovarian cancer
    breast cancer    prostate cancer    lung cancer    renal clear cell carcinoma
    non-small cell lung carcinoma    prostatitis    thyroiditis    chromophobe renal cell carcinoma
    squamous cell carcinoma    oxyphilic adenoma    barrett's esophagus    oral squamous cell carcinoma
    pancreatoblastoma    renal oncocytoma    esophageal squamous cell carcinoma    renal cell carcinoma

    3 diseases from the University of Copenhagen DISEASES database for CLDN7:
    Perineurioma     Carcinoma     Oxyphilic adenoma

    10/18 Novoseek disease relationships for CLDN7 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oncocytoma 73.9 18 18799195 (5), 17449941 (5), 17922590 (4), 18587324 (2) (see all 6)
    renal clear cell carcinoma 64.9 3 17449941 (1), 18784823 (1), 18587324 (1)
    adenocarcinoma gastric 43.5 1 16049341 (1)
    carcinoma renal cell 39.9 14 18799195 (5), 18784823 (3), 18587324 (2), 17922590 (1) (see all 5)
    carcinoma squamous cell 38.4 9 16647955 (4), 17255337 (2), 18547615 (1), 11965536 (1) (see all 5)
    hnscc 37.4 2 11965536 (1), 17541031 (1)
    tumors 36.3 33 17922590 (4), 15790437 (3), 16647955 (2), 16054130 (2) (see all 17)
    primary tumor 36 3 18439941 (1), 16647955 (1)
    breast carcinoma 34.9 3 17223851 (2), 16048505 (1)
    metastasis 33.6 12 16647955 (3), 16048505 (3), 17223851 (2), 18439941 (1) (see all 7)


    Export disorders for CLDN7 gene to outside databases

    Publications
    for CLDN7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN7 gene, integrated from 9 sources (see all 111):
    (articles sorted by number of sources associating them with CLDN7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of the expression of the prostate-specific antigen by claudin-7. (PubMed id 14502431)1, 2, 9 Zheng J.-Y....Pang S. (2003)
    2. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. (PubMed id 12673207)1, 2, 9 Kominsky S.L.... Sukumar S. (2003)
    3. The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7. (PubMed id 16054130)1, 2, 9 Ladwein M....Zoller M. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (1999)
    6. Claudin-7 expression in human epithelial ovarian cancer. (PubMed id 18298564)1, 9 Tassi R.A....Santin A.D. (2008)
    7. Involvement of claudin-7 in HIV infection of CD4(-) cells. (PubMed id 16368003)1, 9 Zheng J....Pang S. (2005)
    8. Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal cancer cells. (PubMed id 18519685)1, 9 Darido C....Hollande F. (2008)
    9. Up-regulated claudin 7 expression in intestinal-type gastric carcinoma. (PubMed id 17611659)1, 9 Park J.Y....Bang S. (2007)
    10. Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. (PubMed id 18799195)1, 9 Osunkoya A.O....Young A.N. (2009)

    External Searches for CLDN7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CLDN7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1366 HGNC: 2049 AceView: CLDN7andGABARAPandDULLARD Ensembl:ENSG00000181885 euGenes: HUgn1366
    ECgene: CLDN7 Kegg: 1366 H-InvDB: CLDN7

    Other Databases showing CLDN7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLDN7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLDN7 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CLDN7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLDN7 gene:
    Search GeneIP for patents involving CLDN7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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