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Aliases for CLDN7 Gene

Aliases for CLDN7 Gene

  • Claudin 7 2 3
  • CEPTRL2 3 4
  • CPETRL2 3 4
  • CLDN-7 3 4
  • Clostridium Perfringens Enterotoxin Receptor-Like 2 3
  • Claudin-1 3
  • Claudin-7 3
  • Hs.84359 3

External Ids for CLDN7 Gene

Previous Symbols for CLDN7 Gene

  • CEPTRL2
  • CPETRL2

Summaries for CLDN7 Gene

Entrez Gene Summary for CLDN7 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

GeneCards Summary for CLDN7 Gene

CLDN7 (Claudin 7) is a Protein Coding gene. Diseases associated with CLDN7 include oxyphilic adenoma and pancreatoblastoma. Among its related pathways are Integrin Pathway and Cell junction organization. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN9.

UniProtKB/Swiss-Prot for CLDN7 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space.

Gene Wiki entry for CLDN7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN7 Gene

Genomics for CLDN7 Gene

Genomic Location for CLDN7 Gene

Start:
7,259,903 bp from pter
End:
7,263,983 bp from pter
Size:
4,081 bases
Orientation:
Minus strand

Genomic View for CLDN7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLDN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN7 Gene

Regulatory Elements for CLDN7 Gene

Proteins for CLDN7 Gene

  • Protein details for CLDN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95471-CLD7_HUMAN
    Recommended name:
    Claudin-7
    Protein Accession:
    O95471
    Secondary Accessions:
    • B2R9X7
    • D3DTP0
    • Q6IPN3
    • Q7Z4Y7
    • Q9BVN0

    Protein attributes for CLDN7 Gene

    Size:
    211 amino acids
    Molecular mass:
    22418 Da
    Quaternary structure:
    • Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts with EPCAM.
    SequenceCaution:
    • Sequence=AAP97219.1; Type=Frameshift; Positions=18, 23; Evidence={ECO:0000305};

    Alternative splice isoforms for CLDN7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLDN7 Gene

Proteomics data for CLDN7 Gene at MOPED

Post-translational modifications for CLDN7 Gene

Other Protein References for CLDN7 Gene

No data available for DME Specific Peptides for CLDN7 Gene

Domains for CLDN7 Gene

Gene Families for CLDN7 Gene

HGNC:

Protein Domains for CLDN7 Gene

Suggested Antigen Peptide Sequences for CLDN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95471

UniProtKB/Swiss-Prot:

CLD7_HUMAN
Family:
  • Belongs to the claudin family.:
    • O95471
genes like me logo Genes that share domains with CLDN7: view

Function for CLDN7 Gene

Molecular function for CLDN7 Gene

GENATLAS Biochemistry: claudin 7,clostridium perfringens enterotoxin receptor-like 2,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands,primarly expressed in lung and kidney
UniProtKB/Swiss-Prot Function: Plays a major role in tight junction-specific obliteration of the intercellular space.
UniProtKB/Swiss-Prot Induction: By androgens.

Gene Ontology (GO) - Molecular Function for CLDN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 16054130
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN7: view
genes like me logo Genes that share phenotypes with CLDN7: view

Animal Models for CLDN7 Gene

MGI Knock Outs for CLDN7:

miRNA for CLDN7 Gene

miRTarBase miRNAs that target CLDN7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CLDN7 Gene

Localization for CLDN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN7 Gene

Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction, tight junction. Note=Co-localizes with EPCAM at the lateral cell membrane and tight junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDN7 Gene COMPARTMENTS Subcellular localization image for CLDN7 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CLDN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005923 bicellular tight junction ISS --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
GO:0016328 lateral plasma membrane IEA --
genes like me logo Genes that share ontologies with CLDN7: view

Pathways for CLDN7 Gene

genes like me logo Genes that share pathways with CLDN7: view

Gene Ontology (GO) - Biological Process for CLDN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
genes like me logo Genes that share ontologies with CLDN7: view

Compounds for CLDN7 Gene

(1) Novoseek inferred chemical compound relationships for CLDN7 Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 19.9 2
genes like me logo Genes that share compounds with CLDN7: view

Transcripts for CLDN7 Gene

Unigene Clusters for CLDN7 Gene

Claudin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for CLDN7 Gene

GeneLoc Exon Structure for
CLDN7
ECgene alternative splicing isoforms for
CLDN7

Expression for CLDN7 Gene

mRNA expression in normal human tissues for CLDN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN7 Gene

This gene is overexpressed in Colon - Transverse (13.2), Esophagus - Mucosa (8.7), Small Intestine - Terminal Ileum (5.1), and Minor Salivary Gland (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLDN7 Gene

SOURCE GeneReport for Unigene cluster for CLDN7 Gene Hs.513915

mRNA Expression by UniProt/SwissProt for CLDN7 Gene

O95471-CLD7_HUMAN
Tissue specificity: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
genes like me logo Genes that share expressions with CLDN7: view

Orthologs for CLDN7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLDN7 35
  • 99.53 (n)
  • 99.05 (a)
CLDN7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLDN7 35
  • 89.89 (n)
  • 92.42 (a)
CLDN7 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLDN7 35
  • 89.57 (n)
  • 92.89 (a)
CLDN7 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cldn7 35
  • 87.84 (n)
  • 91.94 (a)
Cldn7 16
Cldn7 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLDN7 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldn7 35
  • 86.89 (n)
  • 92.89 (a)
zebrafish
(Danio rerio)
Actinopterygii cldn7a 36
  • 56 (a)
OneToMany
cldn7b 35
  • 58.93 (n)
  • 61.14 (a)
cldn7b 36
  • 60 (a)
OneToMany
Species with no ortholog for CLDN7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN7 Gene

ENSEMBL:
Gene Tree for CLDN7 (if available)
TreeFam:
Gene Tree for CLDN7 (if available)

Paralogs for CLDN7 Gene

Pseudogenes.org Pseudogenes for CLDN7 Gene

genes like me logo Genes that share paralogs with CLDN7: view

Variants for CLDN7 Gene

Sequence variations from dbSNP and Humsavar for CLDN7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs222857 -- 7,261,244(+) AACTG(A/C/G/T)CCTGG intron-variant
rs2521990 -- 7,265,075(+) aagtg(C/G)tggga upstream-variant-2KB
rs9912315 -- 7,260,487(+) GATGA(A/C)TAGGG reference, missense, stop-lost
rs11650636 -- 7,264,915(+) caatt(C/T)tcctg upstream-variant-2KB
rs11655844 -- 7,261,967(+) GGATG(G/T)CGGTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for CLDN7 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
esv2665200 CNV Deletion 23128226
dgv3053n71 CNV Loss 21882294
nsv907637 CNV Loss 21882294
nsv907640 CNV Loss 21882294
nsv1963 CNV Loss 18451855

Relevant External Links for CLDN7 Gene

HapMap Linkage Disequilibrium report
CLDN7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN7 Gene

Disorders for CLDN7 Gene

(3) University of Copenhagen DISEASES for CLDN7 Gene

(18) Novoseek inferred disease relationships for CLDN7 Gene

Disease -log(P) Hits PubMed IDs
oncocytoma 73.9 18
renal clear cell carcinoma 64.9 3
adenocarcinoma gastric 43.5 1
carcinoma renal cell 39.9 12
carcinoma squamous cell 38.4 9
genes like me logo Genes that share disorders with CLDN7: view

No data available for UniProtKB/Swiss-Prot for CLDN7 Gene

Publications for CLDN7 Gene

  1. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. (PMID: 12673207) Kominsky S.L. … Sukumar S. (Oncogene 2003) 3 4 23
  2. Regulation of the expression of the prostate-specific antigen by claudin-7. (PMID: 14502431) Zheng J.-Y. … Pang S. (J. Membr. Biol. 2003) 3 4 23
  3. The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7. (PMID: 16054130) Ladwein M. … Zoeller M. (Exp. Cell Res. 2005) 3 4 23
  4. Up-regulated claudin 7 expression in intestinal-type gastric carcinoma. (PMID: 17611659) Park J.Y. … Bang S. (Oncol. Rep. 2007) 3 23
  5. Claudin-7 immunohistochemistry in renal tumors: a candidate marker for chromophobe renal cell carcinoma identified by gene expression profiling. (PMID: 17922590) Hornsby C.D. … Young A.N. (Arch. Pathol. Lab. Med. 2007) 3 23

Products for CLDN7 Gene

Sources for CLDN7 Gene

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