Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN7 Gene

protein-coding   GIFtS: 66
GCID: GC17M007163

Claudin 7


(Previous symbols: CEPTRL2, CPETRL2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Claudin 71 2     claudin-12
CEPTRL21 2 3     claudin-72
CPETRL21 2 3     Clostridium Perfringens Enterotoxin Receptor-Like 22
CLDN-72 3     

External Ids:    HGNC: 20491   Entrez Gene: 13662   Ensembl: ENSG000001818857   OMIM: 6091315   UniProtKB: O954713   

Export aliases for CLDN7 gene to outside databases

Previous GC identifers: GC17M007585 GC17M007893 GC17M007106 GC17M007364 GC17M007104 GC17M007103 GC17M007054


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLDN7 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in
different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary
tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced
transcript variants encoding different isoforms have been found.(provided by RefSeq, May 2010)

GeneCards Summary for CLDN7 Gene: 
CLDN7 (claudin 7) is a protein-coding gene. Diseases associated with CLDN7 include lung squamous cell carcinoma, and pancreatoblastoma, and among its related super-pathways are Cell-cell junction organization and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is CLDN4.

UniProtKB/Swiss-Prot: CLD7_HUMAN, O95471
Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

Gene Wiki entry for CLDN7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN7 gene promoter:
         MEF-2A   PPAR-gamma1   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLDN7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

CLDN7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007163:  view genomic region     (about GC identifiers)

Start:
7,163,222 bp from pter      End:
7,167,302 bp from pter
Size:
4,081 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLD7_HUMAN, O95471 (See protein sequence)
Recommended Name: Claudin-7  
Size: 211 amino acids; 22418 Da
Subunit: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form
interacts with EPCAM
Subcellular location: Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction, tight
junction. Note=Co-localizes with EPCAM at the lateral cell membrane and tight junction
Sequence caution: Sequence=AAP97219.1; Type=Frameshift; Positions=18, 23;
Secondary accessions: B2R9X7 D3DTP0 Q6IPN3 Q7Z4Y7 Q9BVN0
Alternative splicing: 2 isoforms:  O95471-1   O95471-2   

Explore the universe of human proteins at neXtProt for CLDN7: NX_O95471

Explore proteomics data for CLDN7 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95471

  • CLDN7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLDN7 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001171951.1  NP_001171952.1  NP_001298.3  

    ENSEMBL proteins: 
     ENSP00000353475   ENSP00000396638   ENSP00000460550   ENSP00000460796   ENSP00000465963  
     ENSP00000467220   ENSP00000445131  
    Reactome Protein details: O95471
    Human Recombinant Protein Products for CLDN7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CLDN7
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CLDN7
    GenScript Custom Purified and Recombinant Proteins Services for CLDN7
    Novus Biologicals CLDN7 Proteins
    Novus Biologicals CLDN7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLDN7 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane IEA--
    GO:0016328lateral plasma membrane IEA--

    CLDN7 for ontologies           About GeneDecksing



    CLDN7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CLDN7
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CLDN7
    GenScript Custom Superior Antibodies Services for CLDN7
    Novus Biologicals CLDN7 Antibodies
    Abcam antibodies for CLDN7
    Cloud-Clone Corp. Antibodies for CLDN7 
    ThermoFisher Antibody for CLDN7
    LSBio Antibodies in human, mouse, rat for CLDN7 

    Assay Products for CLDN7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CLDN7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLDN7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLDN7 
    Cloud-Clone Corp. CLIAs for CLDN7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR003552 Claudin7
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry O95471

    ProtoNet protein and cluster: O95471

    2 Blocks protein domains:
    IPB003552 Claudin-7 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD7_HUMAN, O95471
    Similarity: Belongs to the claudin family


    CLDN7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD7_HUMAN, O95471
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)
    Induction: By androgens

         Genatlas biochemistry entry for CLDN7:
    claudin 7,clostridium perfringens enterotoxin receptor-like 2,integral membrane protein,claudin family of major
    structural components of tight junction (TJ) strands,primarly expressed in lung and kidney

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding IPI16054130
    GO:0042802identical protein binding ISS--
         
    CLDN7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CLDN7:
     Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cldn7):
     growth/size  hematopoietic system  homeostasis/metabolism  integument  mortality/aging 
     renal/urinary system 

    CLDN7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cldn7tm1Yche for CLDN7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLDN7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLDN7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLDN7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLDN7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN7
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN7:
    hsa-miR-1183 hsa-miR-3148 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLDN7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLDN7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLDN7
    Sirion Biotech Customized adenovirus for overexpression of CLDN7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CLDN7 (see all 15)
    OriGene ORF clones in mouse, rat for CLDN7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CLDN7 (NM_001307)
    Sino Biological Human cDNA Clone for CLDN7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN7
    Sirion Biotech Customized lentivirus for stable overexpression of CLDN7 
                         Customized lentivirus expression plasmids for stable overexpression of CLDN7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CLDN7
    Search LifeMap BioReagents cell lines for CLDN7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLDN7 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell-cell junction organization0.69
    Cell-Cell communication0.64
    Cell junction organization0.69
    Tight junction interactions0.49
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    5Tight junction
    Tight junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CLDN7
        Cell adhesion Tight junctions

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN7
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN7
        Cell adhesion Tight junctions


    4        Reactome Pathways for CLDN7
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN7):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLDN7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for CLDN7 (O954712, 3 ENSP000003534754) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOXF2Q9BQY42, 3, ENSP000003604414MINT-66102 I2D: score=5 STRING: ENSP00000360441
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    CLDN3O155513, ENSP000003785774I2D: score=1 STRING: ENSP00000378577
    EPCAMP164223, ENSP000002637354I2D: score=1 STRING: ENSP00000263735
    RBPMSQ930623I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--

    CLDN7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLDN7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN7 (CLD7)

    1 Novoseek inferred chemical compound relationship for CLDN7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 19.9 2 18799195 (1), 18784823 (1)

    Search CenterWatch for drugs/clinical trials and news about CLDN7 / CLD7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLDN7 gene (3 alternative transcripts): 
    NM_001185022.1  NM_001185023.1  NM_001307.5  

    Unigene Cluster for CLDN7:

    Claudin 7
    Hs.513915  [show with all ESTs]
    Unigene Representative Sequence: NM_001307
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360325(uc002gfm.4 uc010cmc.3 uc002gfn.4) ENST00000397317
    ENST00000574070 ENST00000575313 ENST00000571881 ENST00000571932 ENST00000573745
    ENST00000538261
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN7
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN7:
    hsa-miR-1183 hsa-miR-3148 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLDN7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLDN7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN7
    Clone
    Products:
         
    OriGene clones in human, mouse for CLDN7 (see all 15)
    OriGene ORF clones in mouse, rat for CLDN7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CLDN7 (NM_001307)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN7
    Sirion Biotech Customized lentivirus for stable overexpression of CLDN7 
                         Customized lentivirus expression plasmids for stable overexpression of CLDN7 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CLDN7
    OriGene qSTAR qPCR primer pairs in human, mouse for CLDN7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLDN7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN7

    Additional mRNA sequence: 

    AF093823.1 AJ011497.1 AK225418.1 AK313958.1 BC001055.2 BC071844.1 BT006829.1 

    17 DOTS entries:

    DT.120063  DT.95227264  DT.100028964  DT.100037238  DT.99929252  DT.120968552  DT.120968695  DT.120968623 
    DT.100791266  DT.120968459  DT.92400449  DT.95187930  DT.120968791  DT.95160031  DT.120968749  DT.92427696 
    DT.120968475 

    24/672 AceView cDNA sequences (see all 672):

    CN478877 BM851680 AA298491 T32915 BM309960 BM971531 AA477128 BU149493 
    BQ935929 CB269137 CR542235 BM977670 AW273245 AW152092 AA719757 W79938 
    BG056404 AI815068 H45728 BU856629 BF844591 AA991335 AI241959 CR611223 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLDN7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
    SP1:              -     -                       -                                 
    SP2:                                            -                                 
    SP3:                                      -     -                                 
    SP4:                    -                                                         
    SP5:                                                                              


    ECgene alternative splicing isoforms for CLDN7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN7 expression in normal human tissues (normalized intensities)      CLDN7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAGTCCTC
    CLDN7 Expression
    About this image


    CLDN7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Presumptive Podocytes Podocyte Layer
             Renal Collecting Duct System
             kidney ; cells in tubules   
     
     Epithelium
             Human Tracheal Epithelial Cells (HTEpiC)   
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Trachea
             bronchus ; respiratory epithelial cells   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   

    See CLDN7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN7

    SOURCE GeneReport for Unigene cluster: Hs.513915

    UniProtKB/Swiss-Prot: CLD7_HUMAN, O95471
    Tissue specificity: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some
    normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal
    carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein
    level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring
    predominantly in high-grade lesions

        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN7: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CLDN7
    OriGene qSTAR qPCR primer pairs in human, mouse for CLDN7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLDN7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN7 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn71 , 5 claudin 71, 5 87.84(n)1
    91.94(a)1
      11 (42.94 cM)5
    536241  NM_001193619.11  NP_001180548.11 
     699647795 
    zebrafish
    (Danio rerio)
    Actinopterygii cldn7b1 claudin 7b 58.93(n)
    61.14(a)
      60635  NM_131637.1  NP_571712.1 


    ENSEMBL Gene Tree for CLDN7 (if available)
    TreeFam Gene Tree for CLDN7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN7 gene
    CLDN42  CLDN92  CLDN82  CLDN202  CLDN172  CLDN52  CLDN102  CLDN22  
    CLDN152  CLDN12  CLDN32  CLDN142  CLDN62  CLDN192  
    18/19 SIMAP similar genes for CLDN7 using alignment to 6 protein entries:     CLD7_HUMAN (see all proteins) (see all similar genes):
    CLDN1    CLDN19    CLDN4    CLDN6    CLDN9    CLDN3
    CLDN10    CLDN2    CLDN8    CLDN14    CLDN5    CLDN17
    CLDN20    CLDN15    CLDN18    CLDN22    CLDN24    CLDN11

    CLDN7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLDN7
    PGOHUM00000241243


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/115 SNPs in CLDN7 are shown (see all 115)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0145384
    ----see VAR_0145382 V A mis40--------
    rs99123151,2
    C,F,H--7163806(+) GATGAC/ATAGGG 6 /V /F /* /Y mis14Minor allele frequency- A:0.01NS NA 344
    rs2002031621,2
    C,F--7163820(+) ACCCTG/CCCCAG 6 /A /G /Q /E mis11Minor allele frequency- C:0.07EU 157
    rs2022183441,2
    --7163823(+) CTGCCC/TAGCCA 6 * W R G stg1 mis10--------
    rs2003974911,2
    C--7163883(+) AGAAAC/ACCTGG 3 -- int11Minor allele frequency- A:0.00EU 943
    rs3705143691,2
    C--7163896(+) TGCCTC/GTGCCC 3 -- int10--------
    rs1489709011,2
    C,F--7163961(+) CTTACT/CTAATG 5 /K /R mis1 int11Minor allele frequency- C:0.00NA 4548
    rs1409802491,2
    C--7164031(+) AGCTAC/TCAAGG 5 I V mis1 int11Minor allele frequency- T:0.00NA 4552
    rs178494101,2,4
    C,H--7164037(+) CAAGGC/TGGCAA 5 T A mis1 int1 ese33Minor allele frequency- T:0.01NS NA 180
    rs1450209371,2
    C,F--7164038(+) AAGGCG/AGCAAG 5 /A syn1 int11Minor allele frequency- A:0.00NA 4552

    HapMap Linkage Disequilibrium report for CLDN7 (7163222 - 7167302 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CLDN7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2665200CNV Deletion23128226
    esv2422288CNV Deletion17116639
    nsv907637CNV Loss21882294
    dgv3053n71CNV Loss21882294
    nsv907640CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv1963CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLDN7
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609131    OMIM disorders: --

    20/45 diseases for CLDN7 (see all 45):    About MalaCards
    lung squamous cell carcinoma    pancreatoblastoma    oxyphilic adenoma    chromophobe renal cell carcinoma
    mucoepidermoid carcinoma    renal oncocytoma    ductal carcinoma in situ    renal clear cell carcinoma
    perineurioma    ovarian cancer    gastric adenocarcinoma    non-small cell lung carcinoma
    lung cancer    giant cell tumor    hepatocellular carcinoma    synovial sarcoma
    esophageal adenocarcinoma    barrett's esophagus    renal cell carcinoma    prostate cancer

    3 diseases from the University of Copenhagen DISEASES database for CLDN7:
    Perineurioma     Carcinoma     Oxyphilic adenoma

    CLDN7 for disorders           About GeneDecksing

    10/18 Novoseek inferred disease relationships for CLDN7 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oncocytoma 73.9 18 18799195 (5), 17449941 (5), 17922590 (4), 18587324 (2) (see all 6)
    renal clear cell carcinoma 64.9 3 17449941 (1), 18784823 (1), 18587324 (1)
    adenocarcinoma gastric 43.5 1 16049341 (1)
    carcinoma renal cell 39.9 14 18799195 (5), 18784823 (3), 18587324 (2), 17922590 (1) (see all 5)
    carcinoma squamous cell 38.4 9 16647955 (4), 17255337 (2), 18547615 (1), 11965536 (1) (see all 5)
    hnscc 37.4 2 11965536 (1), 17541031 (1)
    tumors 36.3 33 17922590 (4), 15790437 (3), 16647955 (2), 16054130 (2) (see all 17)
    primary tumor 36 3 18439941 (1), 16647955 (1)
    breast carcinoma 34.9 3 17223851 (2), 16048505 (1)
    metastasis 33.6 12 16647955 (3), 16048505 (3), 17223851 (2), 18439941 (1) (see all 7)


    Export disorders for CLDN7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN7 gene, integrated from 9 sources (see all 114):
    (articles sorted by number of sources associating them with CLDN7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of the expression of the prostate-specific antigen by claudin-7. (PubMed id 14502431)1, 2, 9 Zheng J.-Y....Pang S. (2003)
    2. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. (PubMed id 12673207)1, 2, 9 Kominsky S.L.... Sukumar S. (2003)
    3. The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7. (PubMed id 16054130)1, 2, 9 Ladwein M....Zoller M. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (1999)
    6. Claudin-7 expression in human epithelial ovarian cancer. (PubMed id 18298564)1, 9 Tassi R.A....Santin A.D. (2008)
    7. Involvement of claudin-7 in HIV infection of CD4(-) cells. (PubMed id 16368003)1, 9 Zheng J....Pang S. (2005)
    8. Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal cancer cells. (PubMed id 18519685)1, 9 Darido C....Hollande F. (2008)
    9. Up-regulated claudin 7 expression in intestinal-type gastric carcinoma. (PubMed id 17611659)1, 9 Park J.Y....Bang S. (2007)
    10. Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. (PubMed id 18799195)1, 9 Osunkoya A.O....Young A.N. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1366 HGNC: 2049 AceView: CLDN7andGABARAPandDULLARD Ensembl:ENSG00000181885 euGenes: HUgn1366
    ECgene: CLDN7 Kegg: 1366 H-InvDB: CLDN7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLDN7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLDN7 gene:
    Search GeneIP for patents involving CLDN7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CLDN7
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for CLDN7 (Claudin-7)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CLDN7  
     OriGene qPCR primer pairs and template standards for CLDN7   OriGene Protein Over-expression Lysate for CLDN7  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CLDN7  
     OriGene qSTAR qPCR primer pairs in human, mouse for CLDN7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CLDN7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLDN7   OriGene Custom Protein Services for CLDN7  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLDN7
     QIAGEN SeqTarget long-range PCR primers for resequencing CLDN7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN7
     GenScript Custom Purified and Recombinant Proteins Services for CLDN7 GenScript cDNA clones with any tag delivered in your preferred vector for CLDN7
     GenScript Custom Assay Services for CLDN7 GenScript Custom Superior Antibodies Services for CLDN7
     GenScript Custom overexpressing Cell Line Services for CLDN7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CLDN7 promoter
     Search Chromatin IP Primers for CLDN7
     RT2 qPCR Primer Assay in human, mouse, rat CLDN7
     GNC Network for CLDN7
     SABiosciences PCR Arrays including human, mouse, rat CLDN7
     Search Tocris compounds for CLDN7 (CLD7)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CLDN7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CLDN7 antibodies
     CLDN7 proteins
     CLDN7 lysates
     Antibodies for CLDN7
     See all of Abcam's Antibodies, Kits and Proteins for CLDN7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CLDN7
     Antibodies for CLDN7
     ELISAs for CLDN7
     CLIAs for CLDN7
     Search LifeMap BioReagents cell lines for CLDN7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN7
     SwitchGear 3'UTR luciferase reporter plasmids for CLDN7
     SwitchGear Promoter luciferase reporter plasmids for CLDN7
     ThermoFisher Antibody for CLDN7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN7
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CLDN7
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLDN7
    Customized:
     lentivirus for stable overexpression of CLDN7
     lentivirus expression plasmids for stable overexpression of CLDN7
     adenovirus for overexpression of CLDN7
     LSBio Antibodies in human, mouse, rat for CLDN7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CLDN7 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4