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CLDN7 Gene

protein-coding   GIFtS: 66
GCID: GC17M007163

Claudin 7


(Previous symbols: CEPTRL2, CPETRL2)
  See CLDN7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Claudin 71 2     claudin-12
CEPTRL21 2 3     claudin-72
CPETRL21 2 3     Clostridium Perfringens Enterotoxin Receptor-Like 22
CLDN-72 3     

External Ids:    HGNC: 20491   Entrez Gene: 13662   Ensembl: ENSG000001818857   OMIM: 6091315   UniProtKB: O954713   

Export aliases for CLDN7 gene to outside databases

Previous GC identifers: GC17M007585 GC17M007893 GC17M007106 GC17M007364 GC17M007104 GC17M007103 GC17M007054


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLDN7 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in
different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary
tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced
transcript variants encoding different isoforms have been found.(provided by RefSeq, May 2010)

GeneCards Summary for CLDN7 Gene:
CLDN7 (claudin 7) is a protein-coding gene. Diseases associated with CLDN7 include oxyphilic adenoma, and pancreatoblastoma. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is CLDN4.

UniProtKB/Swiss-Prot: CLD7_HUMAN, O95471
Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

Gene Wiki entry for CLDN7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLDN7 gene promoter:
         MEF-2A   PPAR-gamma1   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN7 promoter sequence
   Search Chromatin IP Primers for CLDN7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

CLDN7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007163:  view genomic region     (about GC identifiers)

Start:
7,163,222 bp from pter      End:
7,167,302 bp from pter
Size:
4,081 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLD7_HUMAN, O95471 (See protein sequence)
Recommended Name: Claudin-7  
Size: 211 amino acids; 22418 Da
Subunit: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form
interacts with EPCAM
Sequence caution: Sequence=AAP97219.1; Type=Frameshift; Positions=18, 23;
Secondary accessions: B2R9X7 D3DTP0 Q6IPN3 Q7Z4Y7 Q9BVN0
Alternative splicing: 2 isoforms:  O95471-1   O95471-2   

Explore the universe of human proteins at neXtProt for CLDN7: NX_O95471

Explore proteomics data for CLDN7 at MOPED

Post-translational modifications: 

  • Phosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLDN7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171951.1  NP_001171952.1  NP_001298.3  

    ENSEMBL proteins: 
     ENSP00000353475   ENSP00000396638   ENSP00000460550   ENSP00000460796   ENSP00000465963  
     ENSP00000467220   ENSP00000445131  
    Reactome Protein details: O95471

    CLDN7 Human Recombinant Protein Products:

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    Novus Biologicals CLDN7 Lysates
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    Cloud-Clone Corp. Proteins for CLDN7

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR003552 Claudin7
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry O95471

    ProtoNet protein and cluster: O95471

    2 Blocks protein domains:
    IPB003552 Claudin-7 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD7_HUMAN, O95471
    Similarity: Belongs to the claudin family


    Find genes that share domains with CLDN7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD7_HUMAN, O95471
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)
    Induction: By androgens

         Genatlas biochemistry entry for CLDN7:
    claudin 7,clostridium perfringens enterotoxin receptor-like 2,integral membrane protein,claudin family of major
    structural components of tight junction (TJ) strands,primarly expressed in lung and kidney

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding IPI16054130
    GO:0042802identical protein binding ISS--
         
    Find genes that share ontologies with CLDN7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CLDN7:
     Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cldn7):
     growth/size/body  hematopoietic system  homeostasis/metabolism  integument  mortality/aging 
     renal/urinary system 

    Find genes that share phenotypes with CLDN7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cldn7tm1Yche for CLDN7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLDN7
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLDN7

    miRNA
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    hsa-mir-484 (MIRT042085), hsa-mir-335-5p (MIRT017878)

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    3 qRT-PCR Assays for microRNAs that regulate CLDN7:
    hsa-miR-1183 hsa-miR-3148 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLDN7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLDN7

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    GenScript: all cDNA clones in your preferred vector (see all 3): CLDN7 (NM_001307)
    Sino Biological Human cDNA Clone for CLDN7
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN7

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLD7_HUMAN, O95471: Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction, tight
    junction. Note=Co-localizes with EPCAM at the lateral cell membrane and tight junction
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular2
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0005923tight junction ISS--
    GO:0016021integral component of membrane IEA--
    GO:0016328lateral plasma membrane IEA--

    Find genes that share ontologies with CLDN7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLDN7 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    5Tight junction
    Tight junction


    Find genes that share SuperPaths with CLDN7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLDN7
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN7
        Cell adhesion Tight junctions


    1 Reactome Pathway for CLDN7
        Tight junction interactions


    4 Kegg Pathways  (Kegg details for CLDN7):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN7: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CLDN7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLDN7 (O954712, 3 ENSP000003534754) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOXF2Q9BQY42, 3, ENSP000003604414MINT-66102 I2D: score=5 STRING: ENSP00000360441
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    WNK4Q96J923, ENSP000002469144I2D: score=1 STRING: ENSP00000246914
    CLDN3O155513, ENSP000003785774I2D: score=1 STRING: ENSP00000378577
    EPCAMP164223, ENSP000002637354I2D: score=1 STRING: ENSP00000263735
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--

    Find genes that share ontologies with CLDN7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLDN7 (CLD7)

    1 Novoseek inferred chemical compound relationship for CLDN7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 19.9 2 18799195 (1), 18784823 (1)



    Find genes that share compounds with CLDN7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLDN7 gene (3 alternative transcripts): 
    NM_001185022.1  NM_001185023.1  NM_001307.5  

    Unigene Cluster for CLDN7:

    Claudin 7
    Hs.513915  [show with all ESTs]
    Unigene Representative Sequence: NM_001307
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360325(uc002gfm.4 uc010cmc.3 uc002gfn.4) ENST00000397317
    ENST00000574070 ENST00000575313 ENST00000571881 ENST00000571932 ENST00000573745
    ENST00000538261
    miRNA
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    hsa-miR-1183 hsa-miR-3148 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLDN7 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat CLDN7

    Additional mRNA sequence: 

    AF093823.1 AJ011497.1 AK225418.1 AK313958.1 BC001055.2 BC071844.1 BT006829.1 

    17 DOTS entries:

    DT.120063  DT.95227264  DT.100028964  DT.100037238  DT.99929252  DT.120968552  DT.120968695  DT.120968623 
    DT.100791266  DT.120968459  DT.92400449  DT.95187930  DT.120968791  DT.95160031  DT.120968749  DT.92427696 
    DT.120968475 

    Selected AceView cDNA sequences (see all 672):

    BM851680 CD675104 AI363755 AA298491 BE615020 CR611348 AA427910 CR606307 
    BG912922 AA903542 AA862576 BU619649 BU735821 CD675321 BM850754 T31543 
    AA838218 BE328782 BU944031 CR594337 BQ962375 BM697638 BE018163 BM309960 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLDN7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
    SP1:              -     -                       -                                 
    SP2:                                            -                                 
    SP3:                                      -     -                                 
    SP4:                    -                                                         
    SP5:                                                                              


    ECgene alternative splicing isoforms for CLDN7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLDN7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAGTCCTC
    CLDN7 Expression
    About this image


    CLDN7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Ureteric Bud Cells Ureteric Bud
             Renal Collecting Duct System
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Somatic Cells Ovigerous Cord
             Oviduct
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
    CLDN7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLDN7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513915

    UniProtKB/Swiss-Prot: CLD7_HUMAN, O95471
    Tissue specificity: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some
    normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal
    carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein
    level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring
    predominantly in high-grade lesions

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN7: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CLDN7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN7 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn71 , 5 claudin 71, 5 87.84(n)1
    91.94(a)1
      11 (42.94 cM)5
    536241  NM_001193619.11  NP_001180548.11 
     699647795 
    zebrafish
    (Danio rerio)
    Actinopterygii cldn7b1 claudin 7b 58.93(n)
    61.14(a)
      60635  NM_131637.1  NP_571712.1 


    ENSEMBL Gene Tree for CLDN7 (if available)
    TreeFam Gene Tree for CLDN7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLDN7 gene
    CLDN42  CLDN92  CLDN82  CLDN202  CLDN172  CLDN52  CLDN22  CLDN12  
    CLDN142  CLDN32  CLDN62  CLDN192  
    Selected SIMAP similar genes for CLDN7 using alignment to 6 protein entries:     CLD7_HUMAN (see all proteins) (see all similar genes):
    CLDN1    CLDN19    CLDN4    CLDN6    CLDN9    CLDN3
    CLDN10    CLDN2    CLDN8    CLDN14    CLDN5    CLDN17
    CLDN20    CLDN15    CLDN18    CLDN22    CLDN24    CLDN11

    Find genes that share paralogs with CLDN7           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CLDN7
    PGOHUM00000241243


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLDN7 (see all 115)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs99123151,2
    C,F,H--7163806(+) GATGAC/ATAGGG 6 /V /F /* /Y mis14Minor allele frequency- A:0.01NS NA 344
    rs2002031621,2
    C,F--7163820(+) ACCCTG/CCCCAG 6 /A /G /Q /E mis11Minor allele frequency- C:0.07EU 157
    rs2022183441,2
    --7163823(+) CTGCCC/TAGCCA 6 * W R G stg1 mis10--------
    rs2003974911,2
    C--7163883(+) AGAAAC/ACCTGG 3 -- int11Minor allele frequency- A:0.00EU 943
    rs3705143691,2
    C--7163896(+) TGCCTC/GTGCCC 3 -- int10--------
    rs1489709011,2
    C,F--7163961(+) CTTACT/CTAATG 5 /K /R mis1 int11Minor allele frequency- C:0.00NA 4548
    rs1409802491,2
    C--7164031(+) AGCTAC/TCAAGG 5 I V mis1 int11Minor allele frequency- T:0.00NA 4552
    rs178494101,2,,4
    C,H--7164037(+) CAAGGC/TGGCAA 5 T A mis1 int1 ese33Minor allele frequency- T:0.01NS NA 180
    rs1450209371,2
    C,F--7164038(+) AAGGCG/AGCAAG 5 /A syn1 int11Minor allele frequency- A:0.00NA 4552
    rs2014812041,2
    C--7164117(+) TCCCAA/GATGGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for CLDN7 (7163222 - 7167302 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CLDN7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665200CNV Deletion23128226
    esv2422288CNV Deletion17116639
    nsv907637CNV Loss21882294
    dgv3053n71CNV Loss21882294
    nsv907640CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv1963CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLDN7
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609131    OMIM disorders: --

    10 diseases for CLDN7:    
    About MalaCards
    oxyphilic adenoma    pancreatoblastoma    mucoepidermoid carcinoma    ductal carcinoma in situ
    perineurioma    ovarian cancer    non-small cell lung carcinoma    lung cancer
    prostate cancer    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for CLDN7:
    Perineurioma     Carcinoma     Oxyphilic adenoma

    Find genes that share disorders with CLDN7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CLDN7 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oncocytoma 73.9 18 18799195 (5), 17449941 (5), 17922590 (4), 18587324 (2) (see all 6)
    renal clear cell carcinoma 64.9 3 17449941 (1), 18784823 (1), 18587324 (1)
    adenocarcinoma gastric 43.5 1 16049341 (1)
    carcinoma renal cell 39.9 14 18799195 (5), 18784823 (3), 18587324 (2), 17922590 (1) (see all 5)
    carcinoma squamous cell 38.4 9 16647955 (4), 17255337 (2), 18547615 (1), 11965536 (1) (see all 5)
    hnscc 37.4 2 11965536 (1), 17541031 (1)
    tumors 36.3 33 17922590 (4), 15790437 (3), 16647955 (2), 16054130 (2) (see all 17)
    primary tumor 36 3 18439941 (1), 16647955 (1)
    breast carcinoma 34.9 3 17223851 (2), 16048505 (1)
    metastasis 33.6 12 16647955 (3), 16048505 (3), 17223851 (2), 18439941 (1) (see all 7)


    Export disorders for CLDN7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLDN7 gene, integrated from 10 sources (see all 114):
    (articles sorted by number of sources associating them with CLDN7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of the expression of the prostate-specific antigen by claudin-7. (PubMed id 14502431)1, 2, 9 Zheng J.-Y....Pang S. (J. Membr. Biol. 2003)
    2. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. (PubMed id 12673207)1, 2, 9 Kominsky S.L.... Sukumar S. (Oncogene 2003)
    3. The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7. (PubMed id 16054130)1, 2, 9 Ladwein M.... Zoeller M. (Exp. Cell Res. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    6. Claudin-7 expression in human epithelial ovarian cancer. (PubMed id 18298564)1, 9 Tassi R.A....Santin A.D. (Int. J. Gynecol. Cancer 2008)
    7. Involvement of claudin-7 in HIV infection of CD4(-) cells. (PubMed id 16368003)1, 9 Zheng J....Pang S. (Retrovirology 2005)
    8. Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal cancer cells. (PubMed id 18519685)1, 9 Darido C....Hollande F. (Cancer Res. 2008)
    9. Up-regulated claudin 7 expression in intestinal-type gastric carcinoma. (PubMed id 17611659)1, 9 Park J.Y....Bang S. (Oncol. Rep. 2007)
    10. Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. (PubMed id 18799195)1, 9 Osunkoya A.O....Young A.N. (Hum. Pathol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1366 HGNC: 2049 AceView: CLDN7andGABARAPandDULLARD Ensembl:ENSG00000181885 euGenes: HUgn1366
    ECgene: CLDN7 Kegg: 1366 H-InvDB: CLDN7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLDN7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLDN7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLDN7 gene:
    Search GeneIP for patents involving CLDN7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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