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Aliases for CLDN6 Gene

Aliases for CLDN6 Gene

  • Claudin 6 2 3
  • Skullin 3 4
  • Claudin-6 3

External Ids for CLDN6 Gene

Previous GeneCards Identifiers for CLDN6 Gene

  • GC16M003085
  • GC16M003064
  • GC16M003004
  • GC16M003036
  • GC16M003056

Summaries for CLDN6 Gene

Entrez Gene Summary for CLDN6 Gene

  • Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]

GeneCards Summary for CLDN6 Gene

CLDN6 (Claudin 6) is a Protein Coding gene. Diseases associated with CLDN6 include monosomy 22 and atypical teratoid rhabdoid tumor. Among its related pathways are Integrin Pathway and Cell junction organization. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN9.

UniProtKB/Swiss-Prot for CLDN6 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity). May act as a coreceptor for HCV entry into hepatic cells.

Gene Wiki entry for CLDN6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN6 Gene

Genomics for CLDN6 Gene

Regulatory Elements for CLDN6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLDN6 Gene

Start:
3,014,712 bp from pter
End:
3,020,071 bp from pter
Size:
5,360 bases
Orientation:
Minus strand

Genomic View for CLDN6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLDN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN6 Gene

Proteins for CLDN6 Gene

  • Protein details for CLDN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56747-CLD6_HUMAN
    Recommended name:
    Claudin-6
    Protein Accession:
    P56747
    Secondary Accessions:
    • B3KQP9
    • D3DUA5

    Protein attributes for CLDN6 Gene

    Size:
    220 amino acids
    Molecular mass:
    23292 Da
    Quaternary structure:
    • Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.

neXtProt entry for CLDN6 Gene

Proteomics data for CLDN6 Gene at MOPED

Post-translational modifications for CLDN6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN6 Gene

Domains for CLDN6 Gene

Gene Families for CLDN6 Gene

HGNC:

Protein Domains for CLDN6 Gene

Suggested Antigen Peptide Sequences for CLDN6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56747

UniProtKB/Swiss-Prot:

CLD6_HUMAN :
  • P56747
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN6: view

Function for CLDN6 Gene

Molecular function for CLDN6 Gene

GENATLAS Biochemistry: claudin 6,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands,not detected in adult tissues
UniProtKB/Swiss-Prot Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity). May act as a coreceptor for HCV entry into hepatic cells.

Gene Ontology (GO) - Molecular Function for CLDN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN6: view
genes like me logo Genes that share phenotypes with CLDN6: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLDN6 Gene

Localization for CLDN6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN6 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDN6 Gene COMPARTMENTS Subcellular localization image for CLDN6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CLDN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLDN6: view

Pathways for CLDN6 Gene

genes like me logo Genes that share pathways with CLDN6: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CLDN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
GO:0045216 cell-cell junction organization IEA --
genes like me logo Genes that share ontologies with CLDN6: view

Transcripts for CLDN6 Gene

mRNA/cDNA for CLDN6 Gene

Unigene Clusters for CLDN6 Gene

Claudin 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN6 Gene

No ASD Table

Relevant External Links for CLDN6 Gene

GeneLoc Exon Structure for
CLDN6
ECgene alternative splicing isoforms for
CLDN6

Expression for CLDN6 Gene

mRNA expression in normal human tissues for CLDN6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN6 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (7.0), Brain - Caudate (basal ganglia) (4.9), Pancreas (4.8), Brain - Cerebellum (4.6), and Brain - Cerebellar Hemisphere (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLDN6 Gene

SOURCE GeneReport for Unigene cluster for CLDN6 Gene Hs.533779

mRNA Expression by UniProt/SwissProt for CLDN6 Gene

P56747-CLD6_HUMAN
Tissue specificity: Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
genes like me logo Genes that share expressions with CLDN6: view

In Situ Assay Products

Orthologs for CLDN6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLDN6 35
  • 99.24 (n)
  • 99.55 (a)
CLDN6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLDN6 35
  • 88.03 (n)
  • 91.36 (a)
CLDN6 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLDN6 35
  • 87.27 (n)
  • 89.09 (a)
CLDN6 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cldn6 35
  • 84.47 (n)
  • 88.13 (a)
Cldn6 16
Cldn6 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLDN6 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldn6 35
  • 83.11 (n)
  • 86.76 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493413 35
  • 69.65 (n)
  • 69.81 (a)
MGC75756 35
zebrafish
(Danio rerio)
Actinopterygii cldnd 35
  • 65.84 (n)
  • 63.37 (a)
Species with no ortholog for CLDN6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN6 Gene

ENSEMBL:
Gene Tree for CLDN6 (if available)
TreeFam:
Gene Tree for CLDN6 (if available)

Paralogs for CLDN6 Gene

Selected SIMAP similar genes for CLDN6 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CLDN6 Gene

genes like me logo Genes that share paralogs with CLDN6: view

Variants for CLDN6 Gene

Sequence variations from dbSNP and Humsavar for CLDN6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2257295 - 3,015,595(-) ATGCC(A/G)TCATC reference, missense
rs2269911 -- 3,015,923(-) GTGAC(C/T)GCTTT reference, synonymous-codon
rs2717701 -- 3,016,167(+) GTCAA(C/G)ACATG intron-variant
rs2717702 -- 3,016,909(+) tccca(A/G)agtgc intron-variant
rs2717703 -- 3,017,587(+) AGCAG(A/G)CCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLDN6 Gene

Variant ID Type Subtype PubMed ID
nsv905162 CNV Gain 21882294
nsv905170 CNV Loss 21882294
dgv2575n71 CNV Loss 21882294
dgv2576n71 CNV Loss 21882294
nsv509588 CNV Insertion 20534489
nsv510673 CNV Loss 20534489
nsv905185 CNV Loss 21882294
dgv2577n71 CNV Loss 21882294
dgv2578n71 CNV Loss 21882294
nsv905193 CNV Loss 21882294
dgv2579n71 CNV Loss 21882294
nsv905197 CNV Loss 21882294
nsv833125 CNV Loss 17160897

Relevant External Links for CLDN6 Gene

HapMap Linkage Disequilibrium report
CLDN6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN6 Gene

Disorders for CLDN6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (5) Diseases for CLDN6 Gene including...

Search for CLDN6 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CLDN6 Gene

(2) Novoseek inferred disease relationships for CLDN6 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 27.6 6
tumors 12 3

Relevant External Links for CLDN6

Genetic Association Database (GAD)
CLDN6
Human Genome Epidemiology (HuGE) Navigator
CLDN6
genes like me logo Genes that share disorders with CLDN6: view

No data available for UniProtKB/Swiss-Prot for CLDN6 Gene

Publications for CLDN6 Gene

  1. Distribution and expression pattern of claudins 6, 7, and 9 in diffuse- and intestinal-type gastric adenocarcinomas. (PMID: 19960275) RendA^n-Huerta E. … MontaA+o L.F. (J Gastrointest Cancer 2010) 3 23
  2. Epithelioid versus rhabdoid glioblastomas are distinguished by monosomy 22 and immunohistochemical expression of INI-1 but not claudin 6. (PMID: 20118769) Kleinschmidt-DeMasters B.K. … Lillehei K.O. (Am. J. Surg. Pathol. 2010) 3 23
  3. Tight junction protein, claudin-6, downregulates the malignant phenotype of breast carcinoma. (PMID: 20215972) Wu Q. … Quan C. (Eur. J. Cancer Prev. 2010) 3 23
  4. [Effects of stable up-regulation of tight junction protein claudin-6 upon biological phenotypes of breast cancer cell MCF-7]. (PMID: 20367941) Wu Q. … Quan C.S. (Zhonghua Yi Xue Za Zhi 2010) 3 23
  5. [Effects of 17I^-estradiol on proliferation and migration of MCF-7 cell by regulating expression of claudin-6]. (PMID: 20388399) Liu Y.F. … Li Y.L. (Zhonghua Bing Li Xue Za Zhi 2010) 3 23

Products for CLDN6 Gene

Sources for CLDN6 Gene

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