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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN6 Gene

protein-coding   GIFtS: 55
GCID: GC16M003056

claudin 6
 Explore 17 diseases affiliated with
CLDN6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLDN6    

Aliases
for CLDN6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Claudin 61 2
Claudin-61
Skullin3
Skullin3

External Ids:    HGNC: 20481   Entrez Gene: 90742   Ensembl: ENSG000001846977   UniProtKB: P567473   

Export aliases for CLDN6 gene to outside databases

Previous GC identifers: GC16M003085 GC16M003064 GC16M003004 GC16M003036


Summaries
for CLDN6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLDN6:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming
continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely
through the paracellular space. These junctions are comprised of sets of continuous networking strands in the
outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This
gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an
integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be
involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.(provided
by RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: CLD6_HUMAN, P56747
Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

Gene Wiki entry for CLDN6


Genomic Views
for CLDN6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN6 gene promoter:
         COUP-TF1   COUP-TF   AP-1   ATF-2   COUP   HNF-4alpha2   c-Jun   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLDN6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLDN6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

CLDN6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M003056:  view genomic region     (about GC identifiers)

Start:
 3,056,167 bp from pter      End:
 3,070,072 bp from pter
Size:
 13,906 bases      Orientation:
 minus strand

Proteins
for CLDN6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLD6_HUMAN, P56747 (See protein sequence)
Recommended Name: Claudin-6  
Size: 220 amino acids; 23292 Da
Subunit: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity)
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By
similarity)
Secondary accessions: B3KQP9 D3DUA5

Explore the universe of human proteins at neXtProt for CLDN6: NX_P56747

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56747

    • CLDN6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_067018.2  
    ENSEMBL proteins: 
     ENSP00000460955   ENSP00000380131   ENSP00000458783   ENSP00000328674  
    Reactome Protein details: P56747
    Human Recombinant Protein Products: 
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    Novus Biologicals CLDN6 Protein
    Novus Biologicals CLDN6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLDN6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane IEA--


    CLDN6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLDN6

    Protein Domains /
    Families
    for CLDN6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLDN6 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017974 Claudin_CS
     IPR003925 Claudin6
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry P56747

    ProtoNet protein and cluster: P56747

    2 Blocks protein families:
    IPB003925 Claudin-6 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD6_HUMAN, P56747
    Similarity: Belongs to the claudin family


    Function
    for CLDN6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLD6_HUMAN, P56747
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

         Genatlas biochemistry entry for CLDN6:
    claudin 6,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural
    components of tight junction (TJ) strands,not detected in adult tissues

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN6:
    hsa-miR-214 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN6 (see all 7)
    OriGene shRNA RFP: CLDN6
    OriGene siRNA: CLDN6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN6

    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for CLDN6

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding ISS--


    CLDN6 for ontologies           About GeneDecksing


    Animal Models:
         9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cldn6):
     craniofacial  embryogenesis  growth/size  integument  limbs/digits/tail 
     mortality/aging  no phenotypic analysis  normal  pigmentation 

    CLDN6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLDN6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Tight junction interactions0.49
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Epithelial Tight Junctions0.36
    3Hepatitis C
    		Hepatitis C1.00
    4Leukocyte transendothelial migration
    		Leukocyte transendothelial migration1.00
    5Tight junction
    		Tight junction1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN6
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    4        Reactome Pathways for CLDN6
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN6):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/25 Interacting proteins for CLDN6 (P567473 ENSP000003286744) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    CLDN1ENSP000002955224STRING: ENSP00000295522
    CLDN10ENSP000002993394STRING: ENSP00000299339
    CLDN11ENSP000000647244STRING: ENSP00000064724
    CLDN14ENSP000003392924STRING: ENSP00000339292
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--


    CLDN6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLDN6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN6
    Search CenterWatch for drugs/clinical trials and news about CLDN6 / CLD6 

    Transcripts
    for CLDN6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLDN6 gene: 
    NM_021195.4  

    Unigene Cluster for CLDN6:

    Claudin 6
    Hs.533779  [show with all ESTs]
    Unigene Representative Sequence: NM_021195
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000576978 ENST00000396925(uc002csu.4) ENST00000572154 ENST00000328796


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    hsa-miR-214 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN6 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: CLDN6
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN6
    Clone
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    GenScript: all cDNA clones in your preferred vector: CLDN6 (NM_021195)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN6 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN6

    Additional cDNA sequence: 

    AF125306.1 AK075329.1 AY358480.1 BC008934.2 BT007399.1 

    5 DOTS entries:

    DT.429950  DT.100754245  DT.102837092  DT.120710488  DT.117534 

    24/51 AceView cDNA sequences (see all 51):

    NM_021195 BM977872 CR614114 BX098817 AA359297 AY358480 AA358861 BC008934 
    BX444798 AI655282 BU844904 BU557055 BU553219 BM750075 AA359301 BU856222 
    BT007399 CD050508 BI769688 BU859458 AF125306 BU931554 BI094364 BU556803 

    GeneLoc Exon Structure


    Expression
    for CLDN6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTGTTAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLDN6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeForegutForegut Endoderm CellsEndoderm
    Gut TubeVentral Foregut EndodermVentral Foregut Endoderm CellsEndoderm
    KidneyUreteric BudUreteric Bud CellsKidney
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasVentral Pancreatic BudImmature Beta Progenitor CellsPancreas
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

    See CLDN6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN6

    SOURCE GeneReport for Unigene cluster: Hs.533779
        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN6: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for CLDN6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN6 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia MGC757562 hypothetical protein MGC75756 76.3(n)    BC059750.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cldnd1 claudin d 65.84(n)
    63.37(a)    		   81583  NM_180964.2  NP_851295.1 


    ENSEMBL Gene Tree for CLDN6 (if available)
    TreeFam Gene Tree for CLDN6 (if available) 

    Paralogs
    for CLDN6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN6 gene
    CLDN92  CLDN42  CLDN82  CLDN202  CLDN172  CLDN52  CLDN22  CLDN102  
    CLDN152  CLDN32  CLDN12  CLDN142  CLDN72  CLDN192  
    18 SIMAP similar genes for CLDN6 using alignment to 3 protein entries:     CLD6_HUMAN (see all proteins):
    CLDN4    CLDN9    CLDN3    CLDN7    CLDN17    CLDN5
    CLDN8    CLDN1    CLDN2    CLDN19    CLDN20    CLDN14
    CLDN18    CLDN15    CLDN24    CLDN10    CLDN22    CLDN25

    CLDN6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLDN6
    PGOHUM00000244281


    Genomic Variants
    for CLDN6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/109 NCBI SNPs in CLDN6 are shown (see all 109)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1387312991,2
    		--3064290(+) CCTTCC/TGTTGC 2 -- ut31 int10--------
    rs1900219021,2
    		--3064524(+) CTGTGC/TGCCGC 2 -- int10--------
    rs1830484331,2
    		--3064663(+) GCCCAC/TCTCTT 2 -- int10--------
    rs27177001,2
    		C,F,H,--3064698(+) TAACCC/TGCTGC 2 -- int119Minor allele frequency- T:0.31NS EA WA NA CSA 2343
    rs80642231,2
    		C,F,H,--3064863(+) CAGGAC/TGGAGG 2 -- ut31 int1 ese319Minor allele frequency- T:0.17NS EA NA WA 2340
    rs759858301,2
    		--3064876(+) ACAGAG/CGTCAG 2 -- int1 ut311Minor allele frequency- C:0.01WA 118
    rs1858328521,2
    		--3064917(+) CAGATC/GATTTG 2 -- int1 ut310--------
    rs1430756461,2
    		C,--3064965(+) GTAGG-/AATGGG 2 -- ut31 int10--------
    rs1903400971,2
    		--3065031(+) CTTGGA/GGACAG 1 -- ut310--------
    rs557304881,2
    		C--3065032(+) TTGGGA/GACAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLDN6 (3056167 - 3070072 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLDN6: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN6
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN6

    Disorders / Diseases
    for CLDN6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLDN6 for disorders           About GeneDecksing

    17 diseases for CLDN6:    About MalaCards
    hepatitis c    atypical teratoid rhabdoid tumor    esophagitis    hepatitis
    rhabdoid tumors    esophageal squamous cell carcinoma    squamous cell carcinoma    embryonal carcinoma
    gastric adenocarcinoma    breast cancer    esophageal cancer    ovarian cancer
    gastric cancer    carcinoma    breast carcinoma    adenocarcinoma
    glioblastoma

    1 disease from the University of Copenhagen DISEASES database for CLDN6:
    Atypical teratoid rhabdoid tumor

    2 Novoseek disease relationships for CLDN6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 27.6 7 20367941 (2), 20215972 (2), 12896909 (1), 17645772 (1)
    tumors 12 4 12896909 (1), 17645772 (1), 19220299 (1)

    Human Genome Epidemiology (HuGE) Navigator: CLDN6 (1 document)

    Export disorders for CLDN6 gene to outside databases

    Publications
    for CLDN6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN6 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with CLDN6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus. (PubMed id 18234789)1, 3 Meertens L....Dragic T. (2008)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (1999)
    6. Tight junction protein, claudin-6, downregulates the malignant phenotype of breast carcinoma. (PubMed id 20215972)1, 9 Wu Q....Quan C. (2010)
    7. [Effects of stable up-regulation of tight junction pr otein claudin-6 upon biological phenotypes of breast cancer cell MCF-7] (PubMed id 20367941)1, 9 Wu Q....Quan C.S. (2010)
    8. [Effects of 17beta-estradiol on proliferation and mig ration of MCF-7 cell by regulating expression of claudin-6.] (PubMed id 20388399)1, 9 Liu Y.F....Li Y.L. (2010)
    9. Claudin 6 is a positive marker for atypical teratoid/ rhabdoid tumors. (PubMed id 19220299)1, 9 Birks D.K....Handler M.H. (2010)
    10. Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. (PubMed id 11923212)1, 9 Turksen K. and Troy T.C. (2002)

    External Searches for CLDN6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CLDN6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9074 HGNC: 2048 AceView: CLDN6 Ensembl:ENSG00000184697 euGenes: HUgn9074
    ECgene: CLDN6 Kegg: 9074 H-InvDB: CLDN6

    Other Databases showing CLDN6 gene

    (According to HUGE)
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    Specialized Databases showing CLDN6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLDN6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLDN6 gene:
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