Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN6 Gene

protein-coding   GIFtS: 58
GCID: GC16M003064

Claudin 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Claudin 61 2
claudin-62
skullin2
Skullin3

External Ids:    HGNC: 20481   Entrez Gene: 90742   Ensembl: ENSG000001846977   UniProtKB: P567473   

Export aliases for CLDN6 gene to outside databases

Previous GC identifers: GC16M003085 GC16M003004 GC16M003036 GC16M003056


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLDN6 Gene:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming
continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely
through the paracellular space. These junctions are comprised of sets of continuous networking strands in the
outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet.
This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is
an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be
involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome
16.(provided by RefSeq, Aug 2010)

GeneCards Summary for CLDN6 Gene: 
CLDN6 (claudin 6) is a protein-coding gene. Diseases associated with CLDN6 include monosomy 22, and gastric adenocarcinoma, and among its related super-pathways are Cell-cell junction organization and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is CLDN4.

UniProtKB/Swiss-Prot: CLD6_HUMAN, P56747
Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

Gene Wiki entry for CLDN6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN6 gene promoter:
         COUP-TF1   COUP-TF   AP-1   ATF-2   COUP   HNF-4alpha2   c-Jun   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLDN6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

CLDN6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M003064:  view genomic region     (about GC identifiers)

Start:
3,064,713 bp from pter      End:
3,070,072 bp from pter
Size:
5,360 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLD6_HUMAN, P56747 (See protein sequence)
Recommended Name: Claudin-6  
Size: 220 amino acids; 23292 Da
Subunit: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity)
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein
(By similarity)
Secondary accessions: B3KQP9 D3DUA5

Explore the universe of human proteins at neXtProt for CLDN6: NX_P56747

Explore proteomics data for CLDN6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P56747

  • CLDN6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLDN6 Protein Expression
    REFSEQ proteins: NP_067018.2  
    ENSEMBL proteins: 
     ENSP00000380131   ENSP00000458783   ENSP00000328674  
    Reactome Protein details: P56747
    Human Recombinant Protein Products for CLDN6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CLDN6
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CLDN6
    GenScript Custom Purified and Recombinant Proteins Services for CLDN6
    Novus Biologicals CLDN6 Protein
    Novus Biologicals CLDN6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLDN6 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    CLDN6 for ontologies           About GeneDecksing



    CLDN6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CLDN6 (Claudin-6)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CLDN6
    GenScript Custom Superior Antibodies Services for CLDN6
    Novus Biologicals CLDN6 Antibodies
    Abcam antibodies for CLDN6
    Cloud-Clone Corp. Antibodies for CLDN6 
    ThermoFisher Antibodies for CLDN6
    LSBio Antibodies in human, mouse, rat for CLDN6 

    Assay Products for CLDN6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CLDN6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLDN6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLDN6 
    Cloud-Clone Corp. CLIAs for CLDN6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR003925 Claudin6
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry P56747

    ProtoNet protein and cluster: P56747

    2 Blocks protein domains:
    IPB003925 Claudin-6 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD6_HUMAN, P56747
    Similarity: Belongs to the claudin family


    CLDN6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD6_HUMAN, P56747
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

         Genatlas biochemistry entry for CLDN6:
    claudin 6,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major
    structural components of tight junction (TJ) strands,not detected in adult tissues

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding ISS--
         
    CLDN6 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cldn6):
     craniofacial  embryogenesis  growth/size  integument  limbs/digits/tail 
     mortality/aging  no phenotypic analysis  normal  pigmentation 

    CLDN6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLDN6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLDN6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLDN6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLDN6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN6
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN6:
    hsa-miR-214 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidCLDN6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLDN6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLDN6
    Sirion Biotech Customized adenovirus for overexpression of CLDN6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CLDN6 (see all 7)
    OriGene ORF clones in mouse, rat for CLDN6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLDN6 (NM_021195)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN6
    Sirion Biotech Customized lentivirus for stable overexpression of CLDN6 
                         Customized lentivirus expression plasmids for stable overexpression of CLDN6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CLDN6
    Search LifeMap BioReagents cell lines for CLDN6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLDN6 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell-cell junction organization0.69
    Cell-Cell communication0.64
    Cell junction organization0.69
    Tight junction interactions0.49
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Tight junction
    Tight junction
    5Leukocyte transendothelial migration
    Leukocyte transendothelial migration

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN6
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    4        Reactome Pathways for CLDN6
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN6):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/25 Interacting proteins for CLDN6 (P567473 ENSP000003286744) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    CLDN1ENSP000002955224STRING: ENSP00000295522
    CLDN10ENSP000002993394STRING: ENSP00000299339
    CLDN11ENSP000000647244STRING: ENSP00000064724
    CLDN14ENSP000003392924STRING: ENSP00000339292
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--

    CLDN6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN6 (CLD6)

    Search CenterWatch for drugs/clinical trials and news about CLDN6 / CLD6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLDN6 gene: 
    NM_021195.4  

    Unigene Cluster for CLDN6:

    Claudin 6
    Hs.533779  [show with all ESTs]
    Unigene Representative Sequence: NM_021195
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396925(uc002csu.4) ENST00000572154 ENST00000328796
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN6
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN6:
    hsa-miR-214 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidCLDN6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLDN6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN6
    Clone
    Products:
         
    OriGene clones in human, mouse for CLDN6 (see all 7)
    OriGene ORF clones in mouse, rat for CLDN6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLDN6 (NM_021195)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN6
    Sirion Biotech Customized lentivirus for stable overexpression of CLDN6 
                         Customized lentivirus expression plasmids for stable overexpression of CLDN6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CLDN6
    OriGene qSTAR qPCR primer pairs in human, mouse for CLDN6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLDN6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN6

    Additional mRNA sequence: 

    AF125306.1 AK075329.1 AY358480.1 BC008934.2 BT007399.1 

    5 DOTS entries:

    DT.429950  DT.100754245  DT.102837092  DT.120710488  DT.117534 

    24/51 AceView cDNA sequences (see all 51):

    AA358861 BM977872 BX098817 AY358480 BC008934 AA359297 CR614114 NM_021195 
    BF059454 BU557055 BM750075 CD050982 AA359301 BI092825 BU556803 AF125306 
    BU931554 BI094364 AW732856 CD171667 CD050508 AW006236 BX418647 BM744646 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN6 expression in normal human tissues (normalized intensities)      CLDN6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGTTAGT
    CLDN6 Expression
    About this image


    CLDN6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 10 entries
             Line H7 (WA07)
             ESI-049   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   
     
     Epithelium
             Human Pulmonary Alveolar Epithelial Cells (HPAEpiC)   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             liver ; bile duct cells   
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5

    See CLDN6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN6

    SOURCE GeneReport for Unigene cluster: Hs.533779
        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN6: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CLDN6
    OriGene qSTAR qPCR primer pairs in human, mouse for CLDN6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLDN6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN6 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn61 , 5 claudin 61, 5 84.47(n)1
    88.13(a)1
      17 (11.99 cM)5
    544191  NM_018777.41  NP_061247.11 
     236793655 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    59(a)
    1 → many
    GL343287.1(1328263-1328919)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC757562 hypothetical protein MGC75756 76.3(n)    BC059750.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cldnd1 claudin d 65.84(n)
    63.37(a)
      81583  NM_180964.2  NP_851295.1 


    ENSEMBL Gene Tree for CLDN6 (if available)
    TreeFam Gene Tree for CLDN6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN6 gene
    CLDN42  CLDN92  CLDN82  CLDN202  CLDN172  CLDN52  CLDN102  CLDN22  
    CLDN152  CLDN12  CLDN32  CLDN142  CLDN72  CLDN192  
    18 SIMAP similar genes for CLDN6 using alignment to 2 protein entries:     CLD6_HUMAN (see all proteins):
    CLDN4    CLDN9    CLDN3    CLDN7    CLDN5    CLDN17
    CLDN1    CLDN8    CLDN19    CLDN2    CLDN14    CLDN20
    CLDN18    CLDN10    CLDN15    CLDN24    CLDN22    CLDN25

    CLDN6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLDN6
    PGOHUM00000244281


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/97 SNPs in CLDN6 are shown (see all 97)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903400971,2
    --3065031(+) CTTGGA/GGACAG 1 -- ut310--------
    rs557304881,2
    C--3065032(+) TTGGGA/GACAGT 1 -- ut310--------
    rs1840673591,2
    C--3065311(+) CACTGC/GCACTT 1 -- ut310--------
    rs2009316681,2
    --3065328(+) GGCTCC/TAGCGC 1 -- ut310--------
    rs1131358011,2
    C,F--3065359(+) TCCACG/ATCAGA 1 -- ut314Minor allele frequency- A:0.00CSA NA EU 5443
    rs2013187841,2
    C--3065361(+) CACGTC/GAGACG 2 S * stop-lost0--------
    rs1412630271,2
    C--3065363(+) CGTCAG/CACGTA 2 /V syn11Minor allele frequency- C:0.00NA 4186
    rs1503181641,2
    C,F--3065365(+) TCAGAC/TGTAAT 2 I V mis11Minor allele frequency- T:0.00NA 4204
    rs1382844321,2
    C,F--3065390(+) TCAGAG/AGGCCC 2 /P syn12Minor allele frequency- A:0.00NA EU 5657
    rs1496057771,2
    C,F--3065397(+) GCCCCC/TGAGAG 2 Q R mis12Minor allele frequency- T:0.00NA EU 5577

    HapMap Linkage Disequilibrium report for CLDN6 (3064713 - 3070072 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for CLDN6 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509588CNV Insertion20534489
    dgv2579n71CNV Loss21882294
    nsv510673CNV Loss20534489
    nsv905193CNV Loss21882294
    nsv905170CNV Loss21882294
    nsv905185CNV Loss21882294
    nsv905197CNV Loss21882294
    dgv2575n71CNV Loss21882294
    nsv833125CNV Loss17160897
    dgv2576n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLDN6
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    16 diseases for CLDN6:    About MalaCards
    monosomy 22    gastric adenocarcinoma    esophagitis    hepatitis c
    rhabdoid tumor    atypical teratoid rhabdoid tumor    esophageal squamous cell carcinoma    esophageal cancer
    hepatitis    endotheliitis    glioblastoma    squamous cell carcinoma
    gastric cancer    adenocarcinoma    breast cancer    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for CLDN6:
    Atypical teratoid rhabdoid tumor

    CLDN6 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CLDN6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 27.6 7 20367941 (2), 20215972 (2), 12896909 (1), 17645772 (1)
    tumors 12 4 12896909 (1), 17645772 (1), 19220299 (1)

    Genetic Association Database (GAD): CLDN6
    Human Genome Epidemiology (HuGE) Navigator: CLDN6 (1 document)

    Export disorders for CLDN6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN6 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with CLDN6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    2. The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus. (PubMed id 18234789)1, 3 Meertens L....Dragic T. (2008)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (1999)
    7. Tight junction protein, claudin-6, downregulates the malignant phenotype of breast carcinoma. (PubMed id 20215972)1, 9 Wu Q....Quan C. (2010)
    8. [Effects of stable up-regulation of tight junction pr otein claudin-6 upon biological phenotypes of breast cancer cell MCF-7] (PubMed id 20367941)1, 9 Wu Q....Quan C.S. (2010)
    9. [Effects of 17beta-estradiol on proliferation and mig ration of MCF-7 cell by regulating expression of claudin-6.] (PubMed id 20388399)1, 9 Liu Y.F....Li Y.L. (2010)
    10. Claudin 6 is a positive marker for atypical teratoid/ rhabdoid tumors. (PubMed id 19220299)1, 9 Birks D.K....Handler M.H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9074 HGNC: 2048 AceView: CLDN6 Ensembl:ENSG00000184697 euGenes: HUgn9074
    ECgene: CLDN6 Kegg: 9074 H-InvDB: CLDN6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLDN6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLDN6 gene:
    Search GeneIP for patents involving CLDN6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CLDN6 (Claudin-6)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for CLDN6 (Claudin-6)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CLDN6  
     OriGene qPCR primer pairs and template standards for CLDN6   OriGene Protein Over-expression Lysate for CLDN6  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CLDN6  
     OriGene qSTAR qPCR primer pairs in human, mouse for CLDN6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CLDN6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLDN6   OriGene Custom Protein Services for CLDN6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLDN6
     QIAGEN SeqTarget long-range PCR primers for resequencing CLDN6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN6
     GenScript Custom Purified and Recombinant Proteins Services for CLDN6 GenScript cDNA clones with any tag delivered in your preferred vector for CLDN6
     GenScript Custom Assay Services for CLDN6 GenScript Custom Superior Antibodies Services for CLDN6
     GenScript Custom overexpressing Cell Line Services for CLDN6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CLDN6 promoter
     Search Chromatin IP Primers for CLDN6
     RT2 qPCR Primer Assay in human, mouse, rat CLDN6
     Search GNC Networks for CLDN6
     SABiosciences PCR Arrays including human, mouse, rat CLDN6
     Search Tocris compounds for CLDN6 (CLD6)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CLDN6 antibodies
     CLDN6 proteins
     CLDN6 lysates
     Antibodies for CLDN6
     See all of Abcam's Antibodies, Kits and Proteins for CLDN6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CLDN6
     Antibodies for CLDN6
     ELISAs for CLDN6
     CLIAs for CLDN6
     Search LifeMap BioReagents cell lines for CLDN6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN6
     SwitchGear 3'UTR luciferase reporter plasmids for CLDN6
     SwitchGear Promoter luciferase reporter plasmids for CLDN6
     ThermoFisher Antibodies for CLDN6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CLDN6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLDN6
    Customized:
     lentivirus for stable overexpression of CLDN6
     lentivirus expression plasmids for stable overexpression of CLDN6
     adenovirus for overexpression of CLDN6
     LSBio Antibodies in human, mouse, rat for CLDN6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CLDN6 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4