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CLDN5 Gene

protein-coding   GIFtS: 62
GCID: GC22M019510

Claudin 5

(Previous name: transmembrane protein deleted in velocardiofacial syndrome)
(Previous symbols: AWAL, TMVCF)
  See CLDN5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Claudin 51 2     TMDVCF2 3
AWAL1 2 3 5     BEC12
TMVCF1 2 3 5     CPETRL12
Transmembrane Protein Deleted In Velocardiofacial Syndrome1 2     claudin-52
Transmembrane Protein Deleted In VCFS2 3     

External Ids:    HGNC: 20471   Entrez Gene: 71222   Ensembl: ENSG000001841137   OMIM: 6021015   UniProtKB: O005013   

Export aliases for CLDN5 gene to outside databases

Previous GC identifers: GC22M016450 GC22M017885 GC22M003131


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLDN5 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have
been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the
same protein have been found for this gene. (provided by RefSeq, Aug 2008)

GeneCards Summary for CLDN5 Gene:
CLDN5 (claudin 5) is a protein-coding gene. Diseases associated with CLDN5 include pancreatoblastoma, and glioblastoma multiforme. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is CLDN4.

UniProtKB/Swiss-Prot: CLD5_HUMAN, O00501
Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

Gene Wiki entry for CLDN5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLDN5 gene promoter:
         TBP   Spz1   ATF-2   MyoD   GATA-1   PPAR-alpha   CRE-BP1   c-Myb   AP-2alpha   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN5 promoter sequence
   Search Chromatin IP Primers for CLDN5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

CLDN5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN5 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M019510:  view genomic region     (about GC identifiers)

Start:
19,510,547 bp from pter      End:
19,515,068 bp from pter
Size:
4,522 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLD5_HUMAN, O00501 (See protein sequence)
Recommended Name: Claudin-5  
Size: 218 amino acids; 23147 Da
Subunit: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ (By similarity)
Secondary accessions: B3KS11 Q53XW2 Q8WUW3

Explore the universe of human proteins at neXtProt for CLDN5: NX_O00501

Explore proteomics data for CLDN5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLDN5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001124333.1  NP_003268.2  

    ENSEMBL proteins: 
     ENSP00000385477   ENSP00000384554   ENSP00000400612  
    Reactome Protein details: O00501

    CLDN5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CLDN5

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR003551 Claudin5
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry O00501

    ProtoNet protein and cluster: O00501

    2 Blocks protein domains:
    IPB003551 Claudin-5 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD5_HUMAN, O00501
    Similarity: Belongs to the claudin family


    Find genes that share domains with CLDN5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD5_HUMAN, O00501
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity)

         Genatlas biochemistry entry for CLDN5:
    claudin 5,clostridium perfringens enterotoxin receptor-like,transmembrane protein,integral membrane
    protein,claudin family of major structural components of tight junction (TJ) strands,expressed in
    lung,heart,skeletal muscle,homolog to rat ventral prostate protein,deleted in velocardiofacial syndrome,DiGeorge
    region

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding ISS--
         
    Find genes that share ontologies with CLDN5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CLDN5:
     Decreased viability with pacli 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cldn5):
     cardiovascular system  mortality/aging  nervous system 

    Find genes that share phenotypes with CLDN5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cldn5tm1Sts for CLDN5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLDN5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLDN5

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLDN5

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    miRTarBase miRNAs that target CLDN5:
    hsa-mir-128-3p (MIRT021935)

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    Search for qRT-PCR Assays for microRNAs that regulate CLDN5
    SwitchGear 3'UTR luciferase reporter plasmidCLDN5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLDN5

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    Sino Biological Human cDNA Clone for CLDN5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN5
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    Addgene plasmids for CLDN5 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLD5_HUMAN, O00501: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005911cell-cell junction IDA18065521
    GO:0005923tight junction ISS--
    GO:0016021integral component of membrane IEA--
    GO:0033270paranode region of axon IEA--

    Find genes that share ontologies with CLDN5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLDN5 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    5Tight junction
    Tight junction


    Find genes that share SuperPaths with CLDN5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLDN5
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    2 GeneGo (Thomson Reuters) Pathways for CLDN5
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions

    1 BioSystems Pathway for CLDN5
        Diurnally regulated genes with circadian orthologs


    1 Reactome Pathway for CLDN5
        Tight junction interactions


    4 Kegg Pathways  (Kegg details for CLDN5):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN5: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CLDN5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLDN5 (O005013 ENSP000003845544) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    CLDN1O958323, ENSP000002955224I2D: score=1 STRING: ENSP00000295522
    CLDN3O155513, ENSP000003785774I2D: score=2 STRING: ENSP00000378577
    MPDZO759703, ENSP000003704104I2D: score=2 STRING: ENSP00000370410
    CLDN10ENSP000002993394STRING: ENSP00000299339
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--
    GO:0042552myelination IEA--

    Find genes that share ontologies with CLDN5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLDN5 (CLD5)

    2 Novoseek inferred chemical compound relationships for CLDN5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 1.92 1 16192992 (1)
    calcium 0 1 18941231 (1)



    Find genes that share compounds with CLDN5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLDN5 gene (2 alternative transcripts): 
    NM_001130861.1  NM_003277.3  

    Unigene Cluster for CLDN5:

    Claudin 5
    Hs.505337  [show with all ESTs]
    Unigene Representative Sequence: AK124019
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406028 ENST00000403084(uc010grr.2) ENST00000413119(uc002zpu.2)

    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CLDN5 (NM_003277)
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      QuantiTect SYBR Green Assays in human, mouse, rat CLDN5
      QuantiFast Probe-based Assays in human, mouse, rat CLDN5

    Additional mRNA sequence: 

    AF000959.1 AK092561.1 AK124019.1 AK222466.1 BC002404.2 BC019290.1 BC032363.1 BT007254.1 
    CR456420.1 

    6 DOTS entries:

    DT.101960841  DT.452060  DT.95140671  DT.86853460  DT.91930373  DT.95140670 

    Selected AceView cDNA sequences (see all 249):

    AU102246 AI971087 CB993088 AI497639 BI962512 AU102249 AI800076 AI970869 
    BI789073 CR456420 BM721132 BF530060 BG742856 BI439642 BQ003128 T35689 
    BC032363 BM920696 BI962693 BU688094 CD172303 CR626038 AI341205 CB959560 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLDN5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCGCGGCT
    CLDN5 Expression
    About this image


    CLDN5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Body Subcutaneous White Adipose
             HyStem+BMP4-induced SM30 cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
             Endothelial cells
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Endothelial cells
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephros
    CLDN5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLDN5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.505337
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN5: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn51 , 5 claudin 51, 5 87(n)1
    91.74(a)1
      16 (11.63 cM)5
    127411  NM_013805.41  NP_038833.21 
     187768475 
    chicken
    (Gallus gallus)
    Aves CLDN51 claudin 5 76.85(n)
    70.83(a)
      374028  NM_204201.1  NP_989532.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060483.12   -- 74.79(n)    BC060483.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cldn5a1 claudin 5a 67.75(n)
    57.67(a)
      406559  NM_213274.1  NP_998439.1 


    ENSEMBL Gene Tree for CLDN5 (if available)
    TreeFam Gene Tree for CLDN5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLDN5 gene
    CLDN42  CLDN92  CLDN82  CLDN202  CLDN172  CLDN22  CLDN12  CLDN142  
    CLDN32  CLDN62  CLDN72  CLDN192  
    18 SIMAP similar genes for CLDN5 using alignment to 2 protein entries:     CLD5_HUMAN (see all proteins):
    CLDN4    CLDN6    CLDN9    CLDN7    CLDN3    CLDN19
    CLDN8    CLDN1    CLDN2    CLDN17    CLDN10    CLDN14
    CLDN20    CLDN15    CLDN18    CLDN24    CLDN22    CLDN25

    Find genes that share paralogs with CLDN5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLDN5 (see all 112)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407439681,2
    --19510287(+) GCCCCC/TGCCCC 2 -- ds50010--------
    rs1840568001,2
    --19510350(+) GATCCC/TGCCTT 2 -- ds50010--------
    rs1496652521,2
    C--19510520(+) AAGATA/GGCTGG 2 -- ds50010--------
    rs1865773731,2
    --19510546(+) CAGGTA/GGGAGA 2 -- ds50010--------
    rs1117605831,2
    C--19510549(+) GTGGGT/AGAGAG 2 -- ut311Minor allele frequency- A:0.00CSA 1
    rs1147748161,2
    C,F--19510585(+) TTAGCC/TTTCCC 2 -- ut311Minor allele frequency- T:0.02WA 118
    rs103141,2
    C,F,H--19510718(-) GTACAG/CCTGGT 2 -- ut31 ese313Minor allele frequency- C:0.31MN NA NS EA CSA WA 1173
    rs454856951,2
    C--19510744(+) GGCCCT/CGGGCT 2 -- ut312Minor allele frequency- C:0.06CSA WA 120
    rs115512561,2
    --19510816(+) CCAGCA/GTCTTG 2 -- ut31 ese30--------
    rs1907958611,2
    C--19510870(+) GAAACA/TGCGCC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CLDN5 (19510547 - 19515068 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CLDN5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv435744CNV Deletion17901297
    nsv834127CNV Loss17160897
    dgv4840n71CNV Loss21882294
    nsv914263CNV Gain21882294
    esv2751940CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLDN5
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602101    OMIM disorders: --

    5 diseases for CLDN5:    
    About MalaCards
    pancreatoblastoma    glioblastoma multiforme    gray platelet syndrome    usual interstitial pneumonia
    idiopathic pulmonary fibrosis

    2 diseases from the University of Copenhagen DISEASES database for CLDN5:
    Brain edema     Brain glioma

    Find genes that share disorders with CLDN5           About GenesLikeMe

    9 Novoseek inferred disease relationships for CLDN5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    edema 36.7 3 16786176 (2)
    epithelial tumor 34.8 1 16990707 (1)
    glioblastoma multiforme 33.8 1 10965803 (1)
    adenocarcinoma 15.5 10 17585317 (2), 20044634 (2), 19231096 (1), 17614851 (1)
    carcinoma squamous cell 4.6 6 17585317 (2), 19231096 (1), 17614851 (1)
    inflammation 3.9 2 18799677 (2)
    tumors 0 6 17585317 (2), 19194274 (1), 10965803 (1)
    carcinoma 0 3 20044634 (1), 16990707 (1)
    immunodeficiency 0 2 15815581 (1), 18187566 (1)

    Genetic Association Database (GAD): CLDN5
    Human Genome Epidemiology (HuGE) Navigator: CLDN5 (4 documents)

    Export disorders for CLDN5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLDN5 gene, integrated from 10 sources (see all 158):
    (articles sorted by number of sources associating them with CLDN5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome. (PubMed id 9192844)1, 2, 3, 9 Sirotkin H.... Kucherlapati R. (Genomics 1997)
    2. Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia. (PubMed id 18797402)1, 4 Ishiguro H....Arinami T. (Psychiatr. Genet. 2008)
    3. A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. (PubMed id 16181776)1, 4 Wei J. and Hemmings G.P. (Prostaglandins Leukot. Essent. Fatty Acids 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Analysis of a human gene homologous to rat ventral prostate.1 protein. (PubMed id 9441748)1, 3 Peacock R.E.... Inglehearn C.F. (Genomics 1997)
    8. Claudin-5 levels are reduced in human end-stage cardiomyopathy. (PubMed id 18513742)1, 9 Mays T.A....Rafael-Fortney J.A. (J. Mol. Cell. Cardiol. 2008)
    9. Limited contribution of claudin-5-dependent tight junction strands to endothelial barrier function. (PubMed id 16959372)1, 9 Fontijn R.D....Horrevoets A.J. (Eur. J. Cell Biol. 2006)
    10. Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells. (PubMed id 16158492)1, 9 Amasheh S....Fromm M. (Cell Tissue Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 7122 HGNC: 2047 AceView: CLDN5 Ensembl:ENSG00000184113 euGenes: HUgn7122
    ECgene: CLDN5 Kegg: 7122 H-InvDB: CLDN5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CLDN5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CLDN5 gene:
    Search GeneIP for patents involving CLDN5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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