Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLDN5 Gene

Aliases for CLDN5 Gene

  • Claudin 5 2 3
  • TMVCF 3 4 6
  • AWAL 3 4 6
  • Transmembrane Protein Deleted In Velocardiofacial Syndrome 2 3
  • Transmembrane Protein Deleted In VCFS 3 4
  • TMDVCF 3 4
  • Claudin-5 3
  • CPETRL1 3
  • BEC1 3

External Ids for CLDN5 Gene

Previous Symbols for CLDN5 Gene

  • AWAL
  • TMVCF

Summaries for CLDN5 Gene

Entrez Gene Summary for CLDN5 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for CLDN5 Gene

CLDN5 (Claudin 5) is a Protein Coding gene. Diseases associated with CLDN5 include pancreatoblastoma and glioblastoma multiforme. Among its related pathways are Integrin Pathway and Cell junction organization. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN9.

UniProtKB/Swiss-Prot for CLDN5 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space.

Gene Wiki entry for CLDN5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN5 Gene

Genomics for CLDN5 Gene

Genomic Location for CLDN5 Gene

Start:
19,523,024 bp from pter
End:
19,527,545 bp from pter
Size:
4,522 bases
Orientation:
Minus strand

Genomic View for CLDN5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLDN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN5 Gene

Regulatory Elements for CLDN5 Gene

Proteins for CLDN5 Gene

  • Protein details for CLDN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00501-CLD5_HUMAN
    Recommended name:
    Claudin-5
    Protein Accession:
    O00501
    Secondary Accessions:
    • B3KS11
    • Q53XW2
    • Q8WUW3

    Protein attributes for CLDN5 Gene

    Size:
    218 amino acids
    Molecular mass:
    23147 Da
    Quaternary structure:
    • Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ (By similarity).

neXtProt entry for CLDN5 Gene

Proteomics data for CLDN5 Gene at MOPED

Post-translational modifications for CLDN5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN5 Gene

Domains for CLDN5 Gene

Gene Families for CLDN5 Gene

HGNC:

Protein Domains for CLDN5 Gene

Graphical View of Domain Structure for InterPro Entry

O00501

UniProtKB/Swiss-Prot:

CLD5_HUMAN
Family:
  • Belongs to the claudin family.:
    • O00501
genes like me logo Genes that share domains with CLDN5: view

Function for CLDN5 Gene

Molecular function for CLDN5 Gene

GENATLAS Biochemistry: claudin 5,clostridium perfringens enterotoxin receptor-like,transmembrane protein,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands,expressed in lung,heart,skeletal muscle,homolog to rat ventral prostate protein,deleted in velocardiofacial syndrome,DiGeorge region
UniProtKB/Swiss-Prot Function: Plays a major role in tight junction-specific obliteration of the intercellular space.

Gene Ontology (GO) - Molecular Function for CLDN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN5: view

Phenotypes for CLDN5 Gene

genes like me logo Genes that share phenotypes with CLDN5: view

Animal Models for CLDN5 Gene

MGI Knock Outs for CLDN5:

miRNA for CLDN5 Gene

miRTarBase miRNAs that target CLDN5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CLDN5 Gene

Localization for CLDN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN5 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDN5 Gene COMPARTMENTS Subcellular localization image for CLDN5 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CLDN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005911 cell-cell junction IDA 18065521
GO:0005923 bicellular tight junction ISS --
GO:0016021 integral component of membrane IEA --
GO:0033270 paranode region of axon --
genes like me logo Genes that share ontologies with CLDN5: view

Pathways for CLDN5 Gene

genes like me logo Genes that share pathways with CLDN5: view

Gene Ontology (GO) - Biological Process for CLDN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
GO:0042552 myelination --
genes like me logo Genes that share ontologies with CLDN5: view

Compounds for CLDN5 Gene

(2) Novoseek inferred chemical compound relationships for CLDN5 Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 1.92 1
calcium 0 1
genes like me logo Genes that share compounds with CLDN5: view

Transcripts for CLDN5 Gene

Unigene Clusters for CLDN5 Gene

Claudin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN5 Gene

No ASD Table

Relevant External Links for CLDN5 Gene

GeneLoc Exon Structure for
CLDN5
ECgene alternative splicing isoforms for
CLDN5

Expression for CLDN5 Gene

mRNA expression in normal human tissues for CLDN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN5 Gene

This gene is overexpressed in Adipose - Subcutaneous (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLDN5 Gene

SOURCE GeneReport for Unigene cluster for CLDN5 Gene Hs.505337

genes like me logo Genes that share expressions with CLDN5: view

No data available for mRNA Expression by UniProt/SwissProt for CLDN5 Gene

Orthologs for CLDN5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLDN5 35
  • 99.56 (n)
  • 99.34 (a)
CLDN5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLDN5 35
  • 90.52 (n)
  • 93.12 (a)
CLDN5 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLDN5 35
  • 92.97 (n)
  • 93.27 (a)
mouse
(Mus musculus)
Mammalia Cldn5 35
  • 87 (n)
  • 91.74 (a)
Cldn5 16
Cldn5 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLDN5 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldn5 35
  • 86.09 (n)
  • 91.28 (a)
chicken
(Gallus gallus)
Aves CLDN5 35
  • 76.85 (n)
  • 70.83 (a)
CLDN5 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cldn5 35
  • 68.83 (n)
  • 66.67 (a)
zebrafish
(Danio rerio)
Actinopterygii cldn5a 35
  • 67.75 (n)
  • 57.67 (a)
cldn5a 36
  • 58 (a)
OneToMany
cldn5b 36
  • 55 (a)
OneToMany
cldnk 36
  • 49 (a)
OneToMany
FP102191.1 36
  • 40 (a)
OneToMany
Species with no ortholog for CLDN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN5 Gene

ENSEMBL:
Gene Tree for CLDN5 (if available)
TreeFam:
Gene Tree for CLDN5 (if available)

Paralogs for CLDN5 Gene

Selected SIMAP similar genes for CLDN5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLDN5: view

Variants for CLDN5 Gene

Sequence variations from dbSNP and Humsavar for CLDN5 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs10314 -- 19,523,195(-) GTACA(C/G)CTGGT utr-variant-3-prime
rs739370 -- 19,526,873(+) TTTGG(C/T)GGCAG upstream-variant-2KB, utr-variant-5-prime
rs739371 -- 19,526,475(+) CCCAG(C/G)AGACT upstream-variant-2KB, intron-variant
rs756654 -- 19,523,532(+) CGGGG(A/C)TCCCC utr-variant-3-prime
rs885984 -- 19,523,485(+) CCGAG(A/G)AGCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CLDN5 Gene

Variant ID Type Subtype PubMed ID
nsv435744 CNV Deletion 17901297
nsv914263 CNV Gain 21882294
nsv834127 CNV Loss 17160897
dgv4840n71 CNV Loss 21882294
esv2751940 CNV Gain 17911159

Relevant External Links for CLDN5 Gene

HapMap Linkage Disequilibrium report
CLDN5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN5 Gene

Disorders for CLDN5 Gene

(2) University of Copenhagen DISEASES for CLDN5 Gene

(9) Novoseek inferred disease relationships for CLDN5 Gene

Disease -log(P) Hits PubMed IDs
edema 36.7 2
epithelial tumor 34.8 1
glioblastoma multiforme 33.8 1
adenocarcinoma 15.5 6
carcinoma squamous cell 4.6 4

Relevant External Links for CLDN5

Genetic Association Database (GAD)
CLDN5
Human Genome Epidemiology (HuGE) Navigator
CLDN5
genes like me logo Genes that share disorders with CLDN5: view

No data available for UniProtKB/Swiss-Prot for CLDN5 Gene

Publications for CLDN5 Gene

  1. Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome. (PMID: 9192844) Sirotkin H. … Kucherlapati R. (Genomics 1997) 2 3 4 23
  2. Claudin 5 is transiently expressed during the development of the retinal pigment epithelium. (PMID: 11944085) Kojima S. … Rizzolo L.J. (J. Membr. Biol. 2002) 3 23
  3. Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells. (PMID: 12403818) Poliak S. … Peles E. (J. Cell Biol. 2002) 3 23
  4. Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. (PMID: 12734665) Wolburg H. … Engelhardt B. (Acta Neuropathol. 2003) 3 23
  5. Role of claudin interactions in airway tight junctional permeability. (PMID: 12909588) Coyne C.B. … Johnson L.G. (Am. J. Physiol. Lung Cell Mol. Physiol. 2003) 3 23

Products for CLDN5 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CLDN5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN5
    • Block miRNA regulation of CLDN5 using miScript Target Protectors
    • Addgene plasmids for CLDN5

    Sources for CLDN5 Gene

    Back to Top

    Content