Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLDN5 Gene

Aliases for CLDN5 Gene

  • Claudin 5 2 3 5
  • Transmembrane Protein Deleted In Velocardiofacial Syndrome 2 3
  • Transmembrane Protein Deleted In VCFS 3 4
  • TMDVCF 3 4
  • TMVCF 3 4
  • AWAL 3 4
  • Claudin-5 3
  • CPETRL1 3
  • BEC1 3

External Ids for CLDN5 Gene

Previous HGNC Symbols for CLDN5 Gene

  • AWAL
  • TMVCF

Previous GeneCards Identifiers for CLDN5 Gene

  • GC22M016450
  • GC22M017885
  • GC22M003131

Summaries for CLDN5 Gene

Entrez Gene Summary for CLDN5 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for CLDN5 Gene

CLDN5 (Claudin 5) is a Protein Coding gene. Diseases associated with CLDN5 include Velocardiofacial Syndrome and Gray Platelet Syndrome. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN9.

UniProtKB/Swiss-Prot for CLDN5 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space.

Gene Wiki entry for CLDN5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN5 Gene

Genomics for CLDN5 Gene

Regulatory Elements for CLDN5 Gene

Enhancers for CLDN5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F019576 1.5 FANTOM5 Ensembl ENCODE 14.7 -50.9 -50878 4.4 ATF1 PKNOX1 GLIS2 GATA2 FOS JUNB ZNF623 MBD2 SMARCA4 PBX2 CLDN5 LINC01311 UFD1L CDC45 CLTCL1 LINC00895 GC22P019632
GH22F019554 0.9 Ensembl ENCODE 12.2 -27.5 -27495 1.4 ZFP64 ARID4B RAD21 RCOR1 FOS MIER2 MTA1 SMARCA4 ZNF341 PBX2 LINC01311 LOC100420177 CLDN5 DGCR8 LINC00895
GH22F019496 0.4 ENCODE 12.2 +30.2 30165 1.1 HDAC1 ATF1 PKNOX1 TBL1XR1 CREB3L1 TSC22D4 ZKSCAN1 ZFHX2 FOXK2 POLR2A SCARF2 CLDN5 CLTCL1 PIR41958 CDC45
GH22F019629 0.8 Ensembl ENCODE 12.1 -102.4 -102449 0.4 HDGF ATF1 PKNOX1 ARNT CREB3L1 ARID4B ZNF48 ZNF2 ZNF143 KLF13 CLDN5 CDC45 UFD1L GC22P019632 LINC00895
GH22F019489 0.3 FANTOM5 11.8 +38.1 38089 0.3 CTCF RFX1 ZNF740 ELF1 RAD21 ETS2 ZNF121 POLR2A SMC3 KLF9 CLDN5 CDC45 PIR41958
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CLDN5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLDN5 Gene

Chromosome:
22
Start:
19,523,024 bp from pter
End:
19,527,545 bp from pter
Size:
4,522 bases
Orientation:
Minus strand

Genomic View for CLDN5 Gene

Genes around CLDN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN5 Gene

Proteins for CLDN5 Gene

  • Protein details for CLDN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00501-CLD5_HUMAN
    Recommended name:
    Claudin-5
    Protein Accession:
    O00501
    Secondary Accessions:
    • B3KS11
    • Q53XW2
    • Q8WUW3

    Protein attributes for CLDN5 Gene

    Size:
    218 amino acids
    Molecular mass:
    23147 Da
    Quaternary structure:
    • Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ (By similarity).

neXtProt entry for CLDN5 Gene

Post-translational modifications for CLDN5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN5 Gene

No data available for DME Specific Peptides for CLDN5 Gene

Domains & Families for CLDN5 Gene

Gene Families for CLDN5 Gene

Graphical View of Domain Structure for InterPro Entry

O00501

UniProtKB/Swiss-Prot:

CLD5_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN5: view

Function for CLDN5 Gene

Molecular function for CLDN5 Gene

GENATLAS Biochemistry:
claudin 5,clostridium perfringens enterotoxin receptor-like,transmembrane protein,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands,expressed in lung,heart,skeletal muscle,homolog to rat ventral prostate protein,deleted in velocardiofacial syndrome,DiGeorge region
UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space.

Gene Ontology (GO) - Molecular Function for CLDN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN5: view
genes like me logo Genes that share phenotypes with CLDN5: view

Animal Models for CLDN5 Gene

MGI Knock Outs for CLDN5:

Animal Model Products

miRNA for CLDN5 Gene

miRTarBase miRNAs that target CLDN5

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CLDN5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLDN5 Gene

Localization for CLDN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN5 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDN5 Gene COMPARTMENTS Subcellular localization image for CLDN5 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CLDN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005911 cell-cell junction IDA 18065521
GO:0005923 bicellular tight junction IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 9192844
genes like me logo Genes that share ontologies with CLDN5: view

Pathways & Interactions for CLDN5 Gene

genes like me logo Genes that share pathways with CLDN5: view

Gene Ontology (GO) - Biological Process for CLDN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003151 outflow tract morphogenesis TAS 9192844
GO:0007043 cell-cell junction assembly IMP 23288152
GO:0007179 transforming growth factor beta receptor signaling pathway IDA 21168935
GO:0007612 learning TAS 9192844
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
genes like me logo Genes that share ontologies with CLDN5: view

No data available for SIGNOR curated interactions for CLDN5 Gene

Drugs & Compounds for CLDN5 Gene

(1) Drugs for CLDN5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CLDN5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLDN5: view

Transcripts for CLDN5 Gene

Unigene Clusters for CLDN5 Gene

Claudin 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CLDN5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN5 Gene

No ASD Table

Relevant External Links for CLDN5 Gene

GeneLoc Exon Structure for
CLDN5
ECgene alternative splicing isoforms for
CLDN5

Expression for CLDN5 Gene

mRNA expression in normal human tissues for CLDN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN5 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.1).

Protein differential expression in normal tissues from HIPED for CLDN5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.6), Platelet (15.6), and Lung (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLDN5 Gene



NURSA nuclear receptor signaling pathways regulating expression of CLDN5 Gene:

CLDN5

SOURCE GeneReport for Unigene cluster for CLDN5 Gene:

Hs.505337
genes like me logo Genes that share expression patterns with CLDN5: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CLDN5 Gene

Orthologs for CLDN5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLDN5 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia CLDN5 34
  • 92.97 (n)
cow
(Bos Taurus)
Mammalia CLDN5 34 35
  • 90.52 (n)
mouse
(Mus musculus)
Mammalia Cldn5 34 16 35
  • 87 (n)
rat
(Rattus norvegicus)
Mammalia Cldn5 34
  • 86.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CLDN5 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLDN5 34 35
  • 76.85 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cldn5 34
  • 68.83 (n)
zebrafish
(Danio rerio)
Actinopterygii cldn5a 34 35
  • 67.75 (n)
cldn5b 35
  • 55 (a)
OneToMany
cldnk 35
  • 49 (a)
OneToMany
FP102191.1 35
  • 40 (a)
OneToMany
Species where no ortholog for CLDN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN5 Gene

ENSEMBL:
Gene Tree for CLDN5 (if available)
TreeFam:
Gene Tree for CLDN5 (if available)

Paralogs for CLDN5 Gene

(18) SIMAP similar genes for CLDN5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLDN5: view

Variants for CLDN5 Gene

Sequence variations from dbSNP and Humsavar for CLDN5 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10314 -- 19,523,195(-) GTACA(C/G)CTGGT utr-variant-3-prime
rs1053613 -- 19,524,109(-) AAGGG(A/C/G)CTGTG reference, synonymous-codon
rs1053640 -- 19,523,212(-) CCCCC(A/C)CCGGA utr-variant-3-prime
rs1053641 -- 19,523,205(-) CGGAA(A/G)ATGTG utr-variant-3-prime
rs1053666 -- 19,523,093(-) TGGGC(A/C)CCGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CLDN5 Gene

Variant ID Type Subtype PubMed ID
dgv4478n100 CNV loss 25217958
esv2751940 CNV gain 17911159
esv3575418 CNV gain 25503493
esv3893434 CNV gain 25118596
nsv588216 CNV gain 21841781
nsv834127 CNV loss 17160897

Variation tolerance for CLDN5 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.81; 83.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLDN5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLDN5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN5 Gene

Disorders for CLDN5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CLDN5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
velocardiofacial syndrome
  • cayler cardiofacial syndrome
gray platelet syndrome
  • gps
- elite association - COSMIC cancer census association via MalaCards
Search CLDN5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLDN5

Genetic Association Database (GAD)
CLDN5
Human Genome Epidemiology (HuGE) Navigator
CLDN5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLDN5
genes like me logo Genes that share disorders with CLDN5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN5 Gene

Publications for CLDN5 Gene

  1. Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome. (PMID: 9192844) Sirotkin H. … Kucherlapati R. (Genomics 1997) 2 3 4 22 64
  2. Expression pattern of claudins 5 and 7 distinguishes solid-pseudopapillary from pancreatoblastoma, acinar cell and endocrine tumors of the pancreas. (PMID: 19194274) Comper F. … Scarpa A. (Am. J. Surg. Pathol. 2009) 3 22 64
  3. Diagnostic utility of expression of claudins in non-small cell lung cancer: different expression profiles in squamous cell carcinomas and adenocarcinomas. (PMID: 19231096) Jung J.H. … Lee K.Y. (Pathol. Res. Pract. 2009) 3 22 64
  4. Structure and function of extracellular claudin domains. (PMID: 19538285) Krause G. … MA1ller S.L. (Ann. N. Y. Acad. Sci. 2009) 3 22 64
  5. Claudin-5 overexpression correlates with aggressive behavior in serous ovarian adenocarcinoma. (PMID: 20044634) Turunen M. … Santala M. (Anticancer Res. 2009) 3 22 64

Products for CLDN5 Gene

Sources for CLDN5 Gene

Content
Loading form....