V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CLDN4 Gene

protein-coding GIFtS: 60

GC07P072880

claudin 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: CPETR, CPETR1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CPE-R ^¹, ², ³
CPE-receptor ^³
CPER ^², ³, ⁵
CPETR ^²
CPETR1 ^², ³, ⁵
WBSCR8 ^¹, ², ³
hCPE-R ^¹, ²

Descriptions
Clostridium perfringens enterotoxin receptor ^³
Clostridium perfringens enterotoxin receptor 1 ^²
Williams-Beuren syndrome chromosomal region 8 protein ^², ³
claudin 4 ^²

External Ids
HGNC: 2046¹
Entrez Gene: 1364²
UniProtKB: O14493³
Ensembl: ENSG00000189143⁷

Search outside databases for aliases for CLDN4 gene

Previous GC identifers: GC07P071885 GC07P072643 GC07P072657 GC07P072654 GC07P072686

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CLDN4:

This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is

a component of tight junction strands and may play a role in internal organ development and

function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a

neurodevelopmental disorder affecting multiple systems. [provided by RefSeq]

UniProtKB/Swiss-Prot: CLD4_HUMAN, O14493

Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By

similarity)

Gene Wiki entry for CLDN4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CLDN4 gene

Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23

CLDN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P072880: (about GC identifiers)

Start:	72,883,129 bp from pter
End:	72,884,951 bp from pter
Size:	1,823 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 72,578,265-72,580,087

RefSeq DNA sequence:

NC_000007.12 NT_007758.11 NT_079593.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CLD4_HUMAN, O14493 (See protein sequence)

Recommended Name: Claudin-4

Size: 209 amino acids; 22077 Da

Subunit: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity)

Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass

membrane protein (By similarity)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001296.1

ENSEMBL proteins:

ENSP00000342445

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Claudin 4)
	Human Recombinant Proteins from Abnova (CLDN4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	9334247 9892664
GO:0005887	integral to plasma membrane	TAS	9334247
GO:0005923	tight junction	ISS	--
GO:0030054	cell junction	IEA	--

About this table

Antibodies for CLDN4:

	Invitrogen Antibodies for CLDN4
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CLDN4
	R&D Systems Antibodies for CLDN4 (Claudin-4)
	Antibodies from Abcam (Claudin 4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CLDN4)
	Novus Biologicals Antibodies for CLDN4

Assays for CLDN4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O14493

ProtoNet protein and cluster: O14493

2 Blocks protein families:

IPB003550 Claudin-4 signature

IPB006187 Claudin family signature

UniProtKB/Swiss-Prot: CLD4_HUMAN, O14493

Similarity: Belongs to the claudin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CLDN4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CLDN4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001305

Applied Biosystems Silencer® siRNAs for CLDN4

Sigma-Aldrich siRNA and siRNA Panels for CLDN4

Sigma-Aldrich shRNA for CLDN4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CLDN4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001305
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001305
untagged cDNA clone in CMV expression vector: NM_001305

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001305

UniProtKB/Swiss-Prot: CLD4_HUMAN, O14493

Function: Plays a major role in tight junction-specific obliteration of the intercellular space (By

claudin 4,clostridium perfringens enterotoxin receptor 4,situated in the Williams-Beuren critical

region,high affinity,claudin family of major structural components of tight junction (TJ)

strands,expressed in lung,intestine and kidney

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	TAS	9334247
GO:0005198	structural molecule activity	IEA	--
GO:0042802	identical protein binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for CLDN4 (Your Favorite Gene powered by Ingenuity)

Tight Junction Signaling
Leukocyte Extravasation Signaling

GeneDecks CLDN4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CLDN4

5/32 Interacting proteins for CLDN4 (ENSP00000342445³) via UniProtKB, MINT, and/or STRING (see all 32 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TJP1	ENSP00000281537³	STRING (score=.996)
TJP2	ENSP00000366453³	STRING (score=.96)
TJP3	ENSP00000262968³	STRING (score=.914)
CDX2	ENSP00000370408³	STRING (score=.887)
MPDZ	ENSP00000370410³	STRING (score=.882)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009405	pathogenesis	TAS	9334247
GO:0016338	calcium-independent cell-cell adhesion	ISS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CLDN4
5 Novoseek chemical compound relationships for CLDN4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
enterotoxin	69.09	14	11691807 (2), 9520948 (2), 18648369 (1), 17804705 (1) (see all 10)
sodium	0.00	1	11375422 (1)
calcium	0.00	3	15753385 (2), 15305371 (1)
progesterone	0.00	1	18752049 (1)
tyrosine	0.00	4	16236711 (1), 16107502 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CLDN4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CLDN4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001305

Sigma-Aldrich siRNA and siRNA Panels for CLDN4

Sigma-Aldrich shRNA for CLDN4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001305

REFSEQ mRNAs for CLDN4 gene:

NM_001305.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001305

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001305
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001305
                                 untagged cDNA clone in CMV expression vector: NM_001305

Additional cDNA sequence:

AK026651.1 AK124076.1 BC000671.2

19 DOTS entries:

DT.95091246 DT.91776441 DT.97856299 DT.100827425 DT.100827398 DT.102833417 DT.100827421 DT.100753784

DT.100800944 DT.100802208 DT.100827424 DT.121098604 DT.91822771 DT.95091223 DT.100802674 DT.100827410

DT.100827417 DT.121098647 DT.40241034

24/730 AceView cDNA sequences (see all 730 ):

CR622785 CR612437 BX434484 AI874198 BM744145 BM820545 BM772178 BM818811

CR618408 BM743760 CR601702 AA293130 AK126462 BM744079 CR618234 AA574044

CR606460 CR616406 CA426597 CK430504 CR616166 CR615421 CR592497 BM853533

highest scoring ESTs for CLDN4:

AB000712 AA149402 AA149417 AA149738 AA157596 AA157892 AA293130 AA293207 AA293763 AA299718

Unigene Clusters for CLDN4:

Claudin 4

Hs.647036 [show with all ESTs], Hs.699253 [show with all ESTs]

Unigene Representative Sequences: AK126462, NM_001305

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CLDN4

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4
SP1:			-		-				-
SP2:					-
SP3:

About this scheme

ECgene alternative splicing isoforms for CLDN4

1 Ensembl transcript including schematic representation:

ENST00000340958

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CLDN4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CLDN4

¹ / ² / ³

6 probe-sets matching CLDN4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35276_at²^{, 3}	U95-A	2	1.00	0.97	0.98	0.98	AB000712	1.00	1.00	1.00	1
87867_r_at²^{, 3}	U95-E	1	0.44	1.00	0.99	0.94	AI276313	0.40	1.00	0.76	1
87864_i_at²^{, 3}	U95-E	1	0.40	1.00	0.95	1.11	AI276313	0.40	1.00	0.76	1
201428_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001305	0.60	1.00	0.82	1
201428_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1569421_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

GeneDecks CLDN4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.647036 Hs.699253
Expression variation in blood from EXPOLDB for CLDN4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CLDN4 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CLDN4¹	--	claudin 4	90.27(n) 91.39(a)	489802 XM_546920.2 XP_546920.2
chimpanzee (Pan troglodytes)	CLDN4¹	--	claudin 4	99.2(n) 100(a)	463464 XM_001148118.1 XP_001148118.1
cow (Bos taurus)	CLDN4¹	--	claudin 4	88.52(n) 88.04(a)	414921 NM_001014391.2 NP_001014413.1
rat (Rattus norvegicus)	Cldn4¹	--	claudin 4	82.93(n) 83.73(a)	304407 NM_001012022.1 NP_001012022.1
mouse (Mus musculus)	Cldn4^{1, 5}	5 (75.00 cM)⁵	claudin 4^{1, 5}	82.62(n)¹ 83.73(a)¹	12740¹ NM_009903.1¹ NP_034033.1¹ AB000713⁵ AC079938⁵ (see all 12)

About this table Species with no ortholog for CLDN4

ENSEMBL Gene Tree for CLDN4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CLDN4 gene

CLDN9² CLDN3² CLDN6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

4 NCBI SNPs in CLDN4 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4717822^1,2	A,C,F,H	72881722(+)	`CATGGG/TTGGGA`	1	--	ng5¹		6		EU EA WA NA	594
--	rs7793313^1,2	A,C	72882218(+)	`TTCACA/GATGCC`	1	--	ng5¹ ese³		0	--	--	--	--
--	rs7793169^1,2	A,C	72882150(+)	`CCACCA/GTCTAC`	1	--	ng5¹ ese³		0	--	--	--	--
--	rs73702577^1,2	--	72882250(+)	`TCCGGC/TGCCCC`	1	--	ng5¹		0	--	--	--	--

About this table
The following additional 11 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs8629	rs11316	rs7455225	rs1127155	rs4304218	rs13232463	rs6946037
rs13223593	rs34646484	rs4255023	rs10949830

HapMap Linkage Disequilibrium images for CLDN4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602909

UniProtKB/Swiss-Prot: CLD4_HUMAN, O14493

Haploinsufficiency of CLDN4 may be the cause of certain cardiovascular and

musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental

disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23

10/25 Novoseek disease relationships for CLDN4 gene (see all 25 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cystadenoma	65.77	1	12855632 (1)
carcinoma papillary	49.01	2	18313739 (1), 17962811 (1)
ovarian cancer	46.20	13	17678893 (4), 12855632 (3), 17653889 (2), 16714763 (1) (see all 7)
epithelial tumor	44.17	1	17609977 (1)
adenocarcinoma	43.50	13	16287068 (2), 17647191 (2), 15693851 (2), 15643498 (1) (see all 9)
gastric carcinoma	43.16	3	18251778 (2), 16220299 (1)
ovarian carcinoma	42.43	6	17647191 (3), 15277215 (1), 12855632 (1)
gastric cancer	40.53	18	18283635 (5), 15643498 (4), 16969486 (3), 17459057 (2) (see all 5)
adenocarcinoma gastric	40.10	3	16492916 (3)
tumors	38.37	39	15693851 (4), 15643498 (3), 16439986 (3), 18439941 (2) (see all 22)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/167 PubMed articles for CLDN4 gene (see all 167 ):

Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. (PubMed id 9334247)^{1, 2, 3, 4} Katahira J....Sugimoto N. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)^{2, 3} Morita K....Tsukita S. (1999)
Altered expression of claudin-3 and claudin-4 in ectopic endometrium of women with endometriosis. (PubMed id 18384777)^{1, 3} Pan X.Y....Wang B. (2009)
Expression of matrix metalloproteinases MMP-2 and MMP-9 in gastric cancer and their relation to claudin-4 expression. (PubMed id 18283635)^{1, 3} Lee L.Y....Hwang T.L. (2008)
Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line. (PubMed id 18786529)^{1, 3} Aono S. and Hirai Y. (2008)
Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas. (PubMed id 16439986)^{1, 3} Lodi C....Schaff Z. (2006)
Loss of the tight junction protein claudin 4 correlates with histological growth-pattern and differentiation in advanced gastric adenocarcinoma. (PubMed id 15643498)^{1, 3} Lee S.K....Kang J.K. (2005)
Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer. (PubMed id 19142967)^{1, 3} Lanigan F....Gallagher W.M. (2009)
Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer. (PubMed id 18313739)^{1, 3} Konecny G.E....Podratz K.C. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1364	HGNC: 2046	AceView: CLDN4	Ensembl:ENSG00000189143	euGenes: HUgn1364
ECgene: CLDN4	H-InvDB: CLDN4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CLDN4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CLDN4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CLDN4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CLDN4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CLDN4		Antibodies for CLDN4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CLDN4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CLDN4)
	Antibodies (CLDN4)
	Chimera RNAi (CLDN4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Claudin 4)
	Antibodies (Claudin 4)

Search OriGene for CLDN4

Search Tocris compounds for CLDN4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CLDN4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CLDN4 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CLDN4 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for CLDN4

Summaries
for CLDN4

Genomic Location
for CLDN4

Proteins
for CLDN4

Protein Domains/
Families
for CLDN4

Gene Function
for CLDN4

Pathways & Interactions
for CLDN4

Drugs & Compounds
for CLDN4

Transcripts
for CLDN4

Expression
for CLDN4

Orthologs
for CLDN4

Paralogs
for CLDN4

SNPs/Variants
for CLDN4

Disorders & Mutations
for CLDN4

Medical News
for CLDN4

Publications
for CLDN4

Search for CLDN4

Genome Databases showing CLDN4

Other Databases showing CLDN4

Specialized Databases showing CLDN4

Licensable Technologies
for CLDN4

Services
for CLDN4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CLDN4 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor CLDN4

Summariesfor CLDN4

Genomic Locationfor CLDN4

Proteinsfor CLDN4

Protein Domains/Familiesfor CLDN4

Gene Functionfor CLDN4

Pathways & Interactionsfor CLDN4

Drugs & Compoundsfor CLDN4

Transcriptsfor CLDN4

Expression for CLDN4

Orthologsfor CLDN4

Paralogsfor CLDN4

SNPs/Variantsfor CLDN4

Disorders & Mutationsfor CLDN4

Medical Newsfor CLDN4

Publicationsfor CLDN4

Search for CLDN4

Genome Databases showing CLDN4

Other Databases showing CLDN4

Specialized Databases showing CLDN4

Licensable Technologiesfor CLDN4

Servicesfor CLDN4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CLDN4

Summaries
for CLDN4

Genomic Location
for CLDN4

Proteins
for CLDN4

Protein Domains/
Families
for CLDN4

Gene Function
for CLDN4

Pathways & Interactions
for CLDN4

Drugs & Compounds
for CLDN4

Transcripts
for CLDN4

Expression
for CLDN4

Orthologs
for CLDN4

Paralogs
for CLDN4

SNPs/Variants
for CLDN4

Disorders & Mutations
for CLDN4

Medical News
for CLDN4

Publications
for CLDN4

Licensable Technologies
for CLDN4

Services
for CLDN4