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Aliases for CLDN34 Gene

Aliases for CLDN34 Gene

  • Claudin 34 2 3 5
  • Claudin-34 3

External Ids for CLDN34 Gene

Summaries for CLDN34 Gene

GeneCards Summary for CLDN34 Gene

CLDN34 (Claudin 34) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CLDN34 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Additional gene information for CLDN34 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN34 Gene

Genomics for CLDN34 Gene

Regulatory Elements for CLDN34 Gene

Enhancers for CLDN34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH009910 0.7 Ensembl ENCODE 13.7 -49.0 -49030 2 ZNF316 JUN ZSCAN4 CLDN34 SHROOM2 ENSG00000206844 GC0XM009875
GH0XH010118 1.6 Ensembl ENCODE dbSUPER 5.1 +159.3 159329 4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 CBX5 ZNF207 CLCN4 CLDN34 ENSG00000202469
GH0XH010003 1.4 Ensembl ENCODE dbSUPER 0.3 +42.7 42661 1 PKNOX1 FOXA2 SIN3A BMI1 BATF RFX5 RCOR1 FOS ATF7 RUNX3 WWC3 CLDN34
GH0XH009980 1.2 FANTOM5 Ensembl ENCODE 0.3 +20.1 20098 2 HDGF SOX13 PKNOX1 IKZF2 CHD2 SOX5 TFE3 ZNF687 NR2F1 ELF1 WWC3 CLDN34
GH0XH010009 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.2 +49.7 49698 2 ELF3 HDGF PKNOX1 FOXA2 RB1 BMI1 ZNF143 ZNF207 ATF7 ETV6 WWC3-AS1 WWC3 CLDN34
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLDN34 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLDN34 Gene

Chromosome:
X
Start:
9,961,359 bp from pter
End:
9,968,373 bp from pter
Size:
7,015 bases
Orientation:
Plus strand

Genomic View for CLDN34 Gene

Genes around CLDN34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN34 Gene

Proteins for CLDN34 Gene

  • Protein details for CLDN34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    H7C241-CLD34_HUMAN
    Recommended name:
    Claudin-34
    Protein Accession:
    H7C241

    Protein attributes for CLDN34 Gene

    Size:
    214 amino acids
    Molecular mass:
    24226 Da
    Quaternary structure:
    • Can form homo- and heteropolymers with other CLDN.

neXtProt entry for CLDN34 Gene

Post-translational modifications for CLDN34 Gene

No Post-translational modifications

Other Protein References for CLDN34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN34 Gene

Domains & Families for CLDN34 Gene

Gene Families for CLDN34 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CLDN34 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

H7C241

UniProtKB/Swiss-Prot:

CLD34_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN34: view

No data available for Suggested Antigen Peptide Sequences for CLDN34 Gene

Function for CLDN34 Gene

Molecular function for CLDN34 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with CLDN34: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN34 Gene

Localization for CLDN34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN34 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN34 gene
Compartment Confidence
plasma membrane 5
lysosome 1

Gene Ontology (GO) - Cellular Components for CLDN34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CLDN34: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLDN34 Gene

Pathways & Interactions for CLDN34 Gene

SuperPathways for CLDN34 Gene

No Data Available

Interacting Proteins for CLDN34 Gene

Gene Ontology (GO) - Biological Process for CLDN34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLDN34 Gene

Drugs & Compounds for CLDN34 Gene

No Compound Related Data Available

Transcripts for CLDN34 Gene

mRNA/cDNA for CLDN34 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN34 Gene

No ASD Table

Relevant External Links for CLDN34 Gene

GeneLoc Exon Structure for
CLDN34
ECgene alternative splicing isoforms for
CLDN34

Expression for CLDN34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLDN34 Gene

NURSA nuclear receptor signaling pathways regulating expression of CLDN34 Gene:

CLDN34
genes like me logo Genes that share expression patterns with CLDN34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN34 Gene

Orthologs for CLDN34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN34 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC100686536 33
  • 71.05 (n)
-- 34
  • 43 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100847650 33
  • 70.21 (n)
-- 34
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC680489 33
  • 62.24 (n)
mouse
(Mus musculus)
Mammalia Gm6927 33
  • 60.51 (n)
Gm7157 34
  • 39 (a)
OneToMany
4930412D23Rik 34
  • 38 (a)
OneToMany
1700042B14Rik 34
  • 36 (a)
OneToMany
4930428D18Rik 34
  • 36 (a)
OneToMany
Gm16390 34
  • 36 (a)
OneToMany
Gm4937 34
  • 36 (a)
OneToMany
4930468A15Rik 34
  • 34 (a)
OneToMany
Gm6604 34
  • 30 (a)
OneToMany
Gm5167 34
  • 29 (a)
OneToMany
3110007F17Rik 34
  • 29 (a)
OneToMany
Cldn34-ps 16
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101749507 33
  • 57.65 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 28 (a)
OneToMany
-- 34
  • 20 (a)
OneToMany
-- 34
  • 19 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732192 33
  • 51.44 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101882682 33
  • 48.4 (n)
CABZ01080074.1 34
  • 33 (a)
OneToMany
CABZ01007930.1 34
  • 23 (a)
OneToMany
Species where no ortholog for CLDN34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN34 Gene

ENSEMBL:
Gene Tree for CLDN34 (if available)
TreeFam:
Gene Tree for CLDN34 (if available)

Paralogs for CLDN34 Gene

No data available for Paralogs for CLDN34 Gene

Variants for CLDN34 Gene

Sequence variations from dbSNP and Humsavar for CLDN34 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000190810 -- 9,962,495(+) GTCTC(A/G)CTCTG intron-variant
rs1000647472 -- 9,961,989(+) TATAG(A/G)CCACA intron-variant
rs1001254145 -- 9,963,762(+) CCTAT(A/G)ATCCT intron-variant
rs1001418516 -- 9,968,398(+) CCTGT(A/C)ATCCC downstream-variant-500B
rs1002662249 -- 9,965,415(+) GCCTC(C/G)CAAAA intron-variant, upstream-variant-2KB

Relevant External Links for CLDN34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLDN34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CLDN34 Gene

Disorders for CLDN34 Gene

Relevant External Links for CLDN34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLDN34

No disorders were found for CLDN34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDN34 Gene

Publications for CLDN34 Gene

  1. Phylogenetic revision of the claudin gene family. (PMID: 23726886) Baltzegar DA … Borski RJ (Marine genomics 2013) 2 3 60
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60

Products for CLDN34 Gene

Sources for CLDN34 Gene

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