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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN3 Gene

protein-coding   GIFtS: 62
GCID: GC07M073183

Claudin 3


(Previous symbols: C7orf1, CPETR2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Claudin 31 2     CPE-R 22 3
CPETR21 2 3 5     CPE-R22
C7orf11 2 3     HRVP12
Clostridium Perfringens Enterotoxin Receptor 21 2 3     RVP12
CPE-Receptor 21 2 3     Ventral Prostate.1 Protein Homolog2
claudin-31 2     hRVP13
Ventral Prostate.1-Like Protein1 2     Rat Ventral Prostate.1 Protein Homolog3

External Ids:    HGNC: 20451   Entrez Gene: 13652   Ensembl: ENSG000001652157   OMIM: 6029105   UniProtKB: O155513   

Export aliases for CLDN3 gene to outside databases

Previous GC identifers: GC07M071823 GC07M072581 GC07M072595 GC07M072627 GC07M072821 GC07M069065


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLDN3 Gene:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming
continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely
through the paracellular space. These junctions are comprised of sets of continuous networking strands in the
outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet.
The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and
a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens
enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. (provided
by RefSeq, Jul 2008)

GeneCards Summary for CLDN3 Gene: 
CLDN3 (claudin 3) is a protein-coding gene. Diseases associated with CLDN3 include malignant peritoneal mesothelioma, and pancreatoblastoma, and among its related super-pathways are Cell-cell junction organization and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include transmembrane signaling receptor activity and identical protein binding. An important paralog of this gene is CLDN4.

UniProtKB/Swiss-Prot: CLD3_HUMAN, O15551
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079593.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN3 gene promoter:
         GR   Sp1   GR-beta   NRSF form 1   NRSF form 2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLDN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11

CLDN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M073183:  view genomic region     (about GC identifiers)

Start:
73,183,327 bp from pter      End:
73,184,600 bp from pter
Size:
1,274 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 72,516,399-72,517,672     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLD3_HUMAN, O15551 (See protein sequence)
Recommended Name: Claudin-3  
Size: 220 amino acids; 23319 Da
Subunit: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2
homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity)
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein
(By similarity)

Explore the universe of human proteins at neXtProt for CLDN3: NX_O15551

Explore proteomics data for CLDN3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15551

  • CLDN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLDN3 Protein Expression
    REFSEQ proteins: NP_001297.1  
    ENSEMBL proteins: 
     ENSP00000378577  
    Reactome Protein details: O15551
    Human Recombinant Protein Products for CLDN3: 
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    Novus Biologicals CLDN3 Protein
    Novus Biologicals CLDN3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLDN3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS9334247
    GO:0005923tight junction IEA--
    GO:0016021integral to membrane TAS9441748

    CLDN3 for ontologies           About GeneDecksing



    CLDN3 Antibody Products: 
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    Cloud-Clone Corp. Antibodies for CLDN3 
    ThermoFisher Antibody for CLDN3
    LSBio Antibodies in human, mouse, rat for CLDN3 

    Assay Products for CLDN3: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CLDN3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLDN3 
    Cloud-Clone Corp. CLIAs for CLDN3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR003549 Claudin3
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry O15551

    ProtoNet protein and cluster: O15551

    2 Blocks protein domains:
    IPB003549 Claudin-3 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD3_HUMAN, O15551
    Similarity: Belongs to the claudin family


    CLDN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD3_HUMAN, O15551
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

         Genatlas biochemistry entry for CLDN3:
    claudin 3,clostridium perfringens enterotoxin receptor 2,low affinity,integral membrane protein,claudin family of
    major structural components of tight junction (TJ) strands,mainly expressed in lung and liver,also in kidney and
    testis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS9334247
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding IEA--
         
    CLDN3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CLDN3:
     Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLDN3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLDN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLDN3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLDN3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CLDN3:
    hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLDN3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLDN3 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell-cell junction organization0.69
    Cell-Cell communication0.64
    Cell junction organization0.69
    Tight junction interactions0.49
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Endothelial cell contacts by junctional mechanisms0.97
    4Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    5Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CLDN3
        Cell adhesion Tight junctions
    Cell adhesion Endothelial cell contacts by junctional mechanisms

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN3
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    2 GeneGo (Thomson Reuters) Pathways for CLDN3
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions

    4        Reactome Pathways for CLDN3
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN3):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLDN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for CLDN3 (O155513 ENSP000003785774) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    CLDN5O005013, ENSP000003845544I2D: score=2 STRING: ENSP00000384554
    PRKACAP176123, ENSP000003095914I2D: score=1 STRING: ENSP00000309591
    WNK4Q96J923, ENSP000002469144I2D: score=1 STRING: ENSP00000246914
    CLDN1O958323, ENSP000002955224I2D: score=2 STRING: ENSP00000295522
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEP15174142
    GO:0016338calcium-independent cell-cell adhesion IEA--

    CLDN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLDN3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN3 (CLD3)

    1 HMDB Compound for CLDN3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 Novoseek inferred chemical compound relationships for CLDN3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    enterotoxin 72.2 7 18569027 (1), 20204275 (1), 17326053 (1), 9878248 (1) (see all 5)
    ochratoxin a 33.5 1 17499213 (1)
    cholesterol 0 5 17762176 (2), 15500448 (1)
    calcium 0 1 15305371 (1)
    vegf 0 4 15161682 (2)

    Search CenterWatch for drugs/clinical trials and news about CLDN3 / CLD3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLDN3 gene: 
    NM_001306.3  

    Unigene Cluster for CLDN3:

    Claudin 3
    Hs.647023  [show with all ESTs]
    Unigene Representative Sequence: NM_001306
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000395145(uc003tzg.4)
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CLDN3:
    hsa-miR-455-3p
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    Inhib. RNA
    Products:
         
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN3
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN3

    Additional mRNA sequence: 

    AB000714.1 AK313276.1 BC009083.1 BC016056.1 

    7 DOTS entries:

    DT.117534  DT.92428811  DT.100780793  DT.100780801  DT.121098596  DT.91822771  DT.97856299 

    24/412 AceView cDNA sequences (see all 412):

    BQ271190 BC009083 AW167849 AI005290 BE019824 BC016056 BM894000 BU785571 
    CA942776 AI271338 AI222788 AI280872 AW015201 AI738744 CB241154 BQ271363 
    AI346569 AW516096 CA943787 CA842897 AW275383 BG656388 AI348231 BU073221 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN3 expression in normal human tissues (normalized intensities)      CLDN3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCGCGCTGG
    CLDN3 Expression
    About this image


    CLDN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Kidney (Urinary System)    fully expand to see all 7 entries
             Loop of Henle Cells Loop of Henle
             Renal Collecting Duct System
             Human Renal Epithelial Cells (HREpiC)   
     
     Epithelium (Uncategorized)    fully expand to see all 3 entries
             Human Renal Epithelial Cells (HREpiC)   
             bronchial epithelia   
     
     Colon (Gastrointestinal Tract)
             colonic mucosal (ibs)   
     
     Uterus (Reproductive System)
             endometrium   
     
     Head Mesenchyme (Muscoskeletal System)
             Frontonasal Process

    See CLDN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN3

    SOURCE GeneReport for Unigene cluster: Hs.647023
        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN3: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN3 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn31 , 5 claudin 31, 5 87.37(n)1
    91.32(a)1
      5 (74.93 cM)5
    127391  NM_009902.41  NP_034032.11 
     1349862145 
    chicken
    (Gallus gallus)
    Aves CLDN31 claudin 3 80.37(n)
    75.7(a)
      374029  NM_204202.1  NP_989533.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLDN36
    Uncharacterized protein
    72(a)
    1 ↔ 1
    GL343462.1(606419-607063)
    zebrafish
    (Danio rerio)
    Actinopterygii cldne2 claudin e 72.65(n)   81584  AF359425.1 


    ENSEMBL Gene Tree for CLDN3 (if available)
    TreeFam Gene Tree for CLDN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN3 gene
    CLDN42  CLDN92  CLDN82  CLDN202  CLDN172  CLDN52  CLDN102  CLDN22  
    CLDN152  CLDN12  CLDN142  CLDN62  CLDN72  CLDN192  
    18/19 SIMAP similar genes for CLDN3 using alignment to 2 protein entries:     CLD3_HUMAN (see all proteins) (see all similar genes):
    CLDN4    CLDN9    CLDN6    CLDN7    CLDN17    CLDN2
    CLDN5    CLDN1    CLDN19    CLDN8    CLDN14    CLDN20
    CLDN18    CLDN10    CLDN15    CLDN22    CLDN24    CLDN25

    CLDN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/87 SNPs in CLDN3 are shown (see all 87)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107097221,2
    C--72516344(+) GCCCCG/-AGGGG 1 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs119798071,2
    C,F,A,H--76708359(+) TTTTCT/GTTTTT 1 -- int121Minor allele frequency- G:0.47NS EA NA WA CSA 2344
    rs1861874531,2
    --76708368(+) TTCCAA/CTAGGA 1 -- int10--------
    rs1919524371,2
    --76708440(+) TTGTGC/TGGGGT 1 -- int10--------
    rs11299651,2
    C--76708889(-) CCCTTC/TTGGAG 1 -- ut312Minor allele frequency- T:0.00MN NA 186
    rs1444966091,2
    --76708909(+) ACAGTC/GCATGC 1 -- ut310--------
    rs1484440021,2
    C,F--76709137(+) CCTTAG/AACGTA 2 /V syn12Minor allele frequency- A:0.00NA EU 4461
    rs1431155321,2
    F--76709266(+) AGCGCG/TCCCCC 2 G syn11Minor allele frequency- T:0.00NA 2672
    rs626377061,2
    C,F--76709305(+) CCCACG/ATACAG 2 /Y syn14Minor allele frequency- A:0.04NS WA CSA 178
    rs1391913281,2
    C,F--76709396(+) ACACCG/AGCACG 2 /P /L mis12Minor allele frequency- A:0.00NA EU 4835

    HapMap Linkage Disequilibrium report for CLDN3 (73183327 - 73184600 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CLDN3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5791CNV Insertion18451855
    nsv831028CNV Loss17160897
    nsv831029CNV Loss17160897
    nsv469841CNV Complex16826518

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602910    OMIM disorders: --

    UniProtKB/Swiss-Prot: CLD3_HUMAN, O15551
  • Note=CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a
    hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing
    over between highly homologous low-copy repeat sequences flanking the deleted region

  • 20/47 diseases for CLDN3 (see all 47):    About MalaCards
    malignant peritoneal mesothelioma    pancreatoblastoma    ovarian cystadenoma    mucoepidermoid carcinoma
    perinatal necrotizing enterocolitis    prostate adenocarcinoma    uterine carcinosarcoma    lung squamous cell carcinoma
    venous insufficiency    peritonitis    endometrial adenocarcinoma    prostatitis
    neurofibroma    cystadenoma    gastric adenocarcinoma    gastroenteritis
    papillary carcinoma    williams-beuren syndrome    endometrial carcinoma    barrett's esophagus

    2 diseases from the University of Copenhagen DISEASES database for CLDN3:
    Ovarian cancer     Carcinoma

    CLDN3 for disorders           About GeneDecksing

    10/28 Novoseek inferred disease relationships for CLDN3 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian carcinoma 58.6 9 17647191 (4), 19567823 (2), 12855632 (1), 17509990 (1)
    ovarian cancer 55.1 23 15905176 (4), 17986852 (3), 19567823 (3), 15899825 (3) (see all 10)
    carcinoma papillary 51.3 3 19426958 (2), 17326053 (1)
    endometrial cancer 43.1 9 18313739 (5), 17326053 (1)
    adenocarcinoma 42.6 16 16287068 (2), 17647191 (2), 16540726 (2), 17509990 (2) (see all 9)
    tumors 42.5 24 12855632 (2), 19082451 (1), 17647191 (1), 15067357 (1) (see all 19)
    carcinoma 38.2 3 16797678 (1), 17647191 (1), 17804705 (1)
    gastric carcinoma 36.2 2 18251778 (2)
    prostatic adenocarcinoma 35.1 3 11691807 (1), 18097572 (1)
    metaplasia 34.2 2 16540726 (1), 17103306 (1)


    Export disorders for CLDN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN3 gene, integrated from 9 sources (see all 154):
    (articles sorted by number of sources associating them with CLDN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of a human gene homologous to rat ventral prostate.1 protein. (PubMed id 9441748)1, 2, 3, 9 Peacock R.E.... Inglehearn C.F. (1997)
    2. Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. (PubMed id 9334247)1, 2, 9 Katahira J....Sugimoto N. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (1999)
    5. Regulation of the CLDN3 gene in ovarian cancer cells. (PubMed id 17986852)1, 9 Honda H....Morin P.J. (2007)
    6. Altered expression of claudin-3 and claudin-4 in ectopic endometrium of women with endometriosis. (PubMed id 18384777)1, 9 Pan X.Y....Wang B. (2009)
    7. Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer. (PubMed id 18313739)1, 9 Konecny G.E....Podratz K.C. (2008)
    8. Expression profile of tight junction protein claudin 3 and claudin 4 in ovarian serous adenocarcinoma with prognostic correlation. (PubMed id 17647191)1, 9 Choi Y.L....Shin Y.K. (2007)
    9. Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. (PubMed id 15905176)1, 9 D'Souza T....Morin P.J. (2005)
    10. Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer. (PubMed id 15240533)1, 9 Heinzelmann-Schwarz V.A....O'Brien P.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
    Disorders
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1365 HGNC: 2045 AceView: CLDN3 Ensembl:ENSG00000165215 euGenes: HUgn1365
    ECgene: CLDN3 Kegg: 1365 H-InvDB: CLDN3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLDN3 gene:
    Search GeneIP for patents involving CLDN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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