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CLDN3 Gene

protein-coding GIFtS: 59

GC07M072821

claudin 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: C7orf1, CPETR2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C7orf1 ^², ³
CPE-R2 ^¹, ²
CPETR2 ^², ³, ⁵
HRVP1 ^¹, ², ³
OTTHUMP00000025042 ^²
OTTHUMP00000160506 ^²
RVP1 ^¹, ²

Descriptions
CPE-R 2 ^³
CPE-receptor 2 ^², ³
Clostridium perfringens enterotoxin receptor 2 ^², ³
Ventral prostate.1 protein homolog ^³
claudin 3 ^²
ventral prostate.1-like protein ^²

External Ids
HGNC: 2045¹
Entrez Gene: 1365²
UniProtKB: O15551³
Ensembl: ENSG00000165215⁷

Search outside databases for aliases for CLDN3 gene

Previous GC identifers: GC07M071823 GC07M072581 GC07M072595 GC07M072627

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CLDN3:

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell

sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes

and water from passing freely through the paracellular space. These junctions are comprised of

sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with

complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this

intronless gene, a member of the claudin family, is an integral membrane protein and a component

of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens

enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in

rat. [provided by RefSeq]

UniProtKB/Swiss-Prot: CLD3_HUMAN, O15551

Function: Plays a major role in tight junction-specific obliteration of the intercellular space,

through calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CLDN3 gene

Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11

CLDN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M072821: (about GC identifiers)

Start:	72,821,263 bp from pter
End:	72,822,536 bp from pter
Size:	1,274 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 72,516,399-72,517,648

RefSeq DNA sequence:

NC_000007.12 NT_007758.11 NT_079593.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CLD3_HUMAN, O15551 (See protein sequence)

Recommended Name: Claudin-3

Size: 220 amino acids; 23319 Da

Subunit: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and

CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity)

Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass

membrane protein (By similarity)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001297.1

ENSEMBL proteins:

ENSP00000378577

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Claudin 3)
	Human Recombinant Proteins from Abnova (CLDN3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	9334247
GO:0005923	tight junction	ISS	--
GO:0030054	cell junction	IEA	--

About this table

Antibodies for CLDN3:

	Invitrogen Antibodies for CLDN3
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CLDN3
	R&D Systems Antibodies for CLDN3 (Claudin-3)
	Antibodies from Abcam (Claudin 3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for CLDN3

Assays for CLDN3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15551

ProtoNet protein and cluster: O15551

2 Blocks protein families:

IPB003549 Claudin-3 signature

IPB006187 Claudin family signature

UniProtKB/Swiss-Prot: CLD3_HUMAN, O15551

Similarity: Belongs to the claudin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CLDN3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CLDN3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001306

Applied Biosystems Silencer® siRNAs for CLDN3

Sigma-Aldrich siRNA and siRNA Panels for CLDN3

Sigma-Aldrich shRNA Panels and shRNA for CLDN3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CLDN3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001306
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001306
untagged cDNA clone in CMV expression vector: NM_001306

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001306

UniProtKB/Swiss-Prot: CLD3_HUMAN, O15551

Function: Plays a major role in tight junction-specific obliteration of the intercellular space,

through calcium-independent cell-adhesion activity (By similarity)

Genatlas biochemistry entry for CLDN3:

claudin 3,clostridium perfringens enterotoxin receptor 2,low affinity,integral membrane

protein,claudin family of major structural components of tight junction (TJ) strands,mainly

expressed in lung and liver,also in kidney and testis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	TAS	9334247
GO:0005198	structural molecule activity	IEA	--
GO:0042802	identical protein binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for CLDN3 (Your Favorite Gene powered by Ingenuity)

Tight Junction Signaling
Leukocyte Extravasation Signaling

GeneDecks CLDN3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CLDN3

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEP	15174142
GO:0016338	calcium-independent cell-cell adhesion	ISS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CLDN3
3 Novoseek chemical compound relationships for CLDN3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
enterotoxin	71.65	5	18569027 (1), 17326053 (1), 9878248 (1), 15899825 (1)
cholesterol	0.00	5	17762176 (2), 15500448 (1)
calcium	0.00	1	15305371 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CLDN3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CLDN3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001306

Sigma-Aldrich siRNA and siRNA Panels for CLDN3

Sigma-Aldrich shRNA Panels and shRNA for CLDN3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001306

REFSEQ mRNAs for CLDN3 gene:

NM_001306.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001306

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001306
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001306
                                 untagged cDNA clone in CMV expression vector: NM_001306

Additional cDNA sequence:

AB000714.1 AK313276.1 BC009083.1 BC016056.1

6 DOTS entries:

DT.117534 DT.92428811 DT.100780793 DT.100780801 DT.121098596 DT.97856299

24/412 AceView cDNA sequences (see all 412 ):

AI304635 BM764241 AI318406 BQ632259 BU071674 AI347072 AW015201 AW043573

AI271338 BQ271363 AI739523 AW516096 AI348231 CK821121 AI761774 AW139257

CB851892 AI077453 BI793298 AA039424 CA842897 NM_001306 BM760760 AW573016

highest scoring ESTs for CLDN3:

AB000714 AA235694 AA292466 AA299806 AA434144 AA434269 AA454509 AA468642 AA468830 AA470827

Unigene Cluster for CLDN3:

Claudin 3

Hs.647023 [show with all ESTs]

Unigene Representative Sequence: NM_001306

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000395145

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CLDN3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CLDN3

¹ / ² / ³

5 probe-sets matching CLDN3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33904_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB000714	1.00	1.00	1.00	1
203954_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001306	0.60	1.00	0.82	1
203953_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE791251	0.20	1.00	0.72	1
203954_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203953_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CLDN3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTCGCGCTGG

SOURCE GeneReport for Unigene cluster: Hs.647023
Expression variation in blood from EXPOLDB for CLDN3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CLDN3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CLDN3¹	--	claudin 3	92.81(n) 91.74(a)	403648 NM_001003088.1 NP_001003088.1
chimpanzee (Pan troglodytes)	CLDN3¹	--	claudin 3	99.39(n) 100(a)	742734 XM_001147969.1 XP_001147969.1
cow (Bos taurus)	CLDN3¹	--	claudin 3	91.02(n) 89.95(a)	404153 NM_205801.2 NP_991370.1
rat (Rattus norvegicus)	Cldn3¹	--	claudin 3	86(n) 90.87(a)	65130 NM_031700.2 NP_113888.2
mouse (Mus musculus)	Cldn3^{1, 5}	5 (75.00 cM)⁵	claudin 3^{1, 5}	87.37(n)¹ 91.32(a)¹	12739¹ NM_009902.3¹ NP_034032.1¹ AB000715⁵ AC084109⁵ (see all 18)

About this table Species with no ortholog for CLDN3

ENSEMBL Gene Tree for CLDN3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CLDN3 gene

CLDN4² CLDN9² CLDN6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/26 NCBI SNPs in CLDN3 are shown (see all 26 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 8)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs11979807^1,2	A,C	72820877(+)	`TTTTCG/TTTTTT`	1	--	ng5¹		0	--	--	--	--
--	rs7084^1,2	A,C	72822371(-)	`CCGGCC/GCCTCG`	1	--	ut5¹		0	--	--	--	--
--	rs6460054^1,2	C,F	72822470(+)	`CTCCAT/CACGCT`	1	--	ut5¹		3		MN EA	1436
--	rs7798722^1,2	A,C	72823498(+)	`aaaaaA/Cttaaa`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs9133^1,2	C	72821982(-)	`ACACGG/TCCAAG`	1	A/S	mis¹ ese³		1		MN	184
--	rs28384435^1,2	F	72823053(-)	`ACCCC-/CACCGC`	1	--	ng3¹		2		MN EA	1252
--	rs1129965^1,2	C	72821408(-)	`CCCTTC/TTGGAG`	1	--	ut3¹		1		MN	184
--	rs33997527^1,2	--	72823671(+)	`AAAAA-/AAAAAA`	1	--	ng3¹		0	--	--	--	--
--	rs13237296^1,2	--	72822848(+)	`CCAAAG/TAATTT`	1	--	ng3¹		0	--	--	--	--
--	rs73364379^1,2	--	72824016(+)	`GCTCAA/CGCCTG`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for CLDN3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602910

UniProtKB/Swiss-Prot: CLD3_HUMAN, O15551

Haploinsufficiency of CLDN3 may be the cause of certain cardiovascular and

musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental

disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23

10/26 Novoseek disease relationships for CLDN3 gene (see all 26 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cancer	55.14	19	15905176 (4), 17986852 (3), 15899825 (3), 12855632 (2) (see all 9)
ovarian carcinoma	54.32	6	17647191 (4), 12855632 (1), 17509990 (1)
carcinoma papillary	49.46	1	17326053 (1)
adenocarcinoma	42.19	13	16287068 (2), 17647191 (2), 16540726 (2), 17509990 (2) (see all 8)
tumors	41.52	21	12855632 (2), 19082451 (1), 17647191 (1), 15067357 (1) (see all 16)
endometrial cancer	41.51	9	18313739 (5), 17326053 (1)
gastric carcinoma	39.38	2	18251778 (2)
prostatic adenocarcinoma	38.21	3	11691807 (1), 18097572 (1)
metaplasia	37.53	2	16540726 (1), 17103306 (1)
endometrial carcinoma	37.18	1	16797678 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/122 PubMed articles for CLDN3 gene (see all 122 ):

Analysis of a human gene homologous to rat ventral prostate.1 protein. (PubMed id 9441748)^{1, 2, 3, 4} Peacock R.E.... Inglehearn C.F. (1997)
Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. (PubMed id 9334247)^{1, 3, 4} Katahira J....Sugimoto N. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)^{2, 3} Morita K....Tsukita S. (1999)
Regulation of the CLDN3 gene in ovarian cancer cells. (PubMed id 17986852)^{1, 3} Honda H....Morin P.J. (2007)
Altered expression of claudin-3 and claudin-4 in ectopic endometrium of women with endometriosis. (PubMed id 18384777)^{1, 3} Pan X.Y....Wang B. (2009)
Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer. (PubMed id 18313739)^{1, 3} Konecny G.E....Podratz K.C. (2008)
Expression profile of tight junction protein claudin 3 and claudin 4 in ovarian serous adenocarcinoma with prognostic correlation. (PubMed id 17647191)^{1, 3} Choi Y.L....Shin Y.K. (2007)
Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. (PubMed id 15905176)^{1, 3} D'Souza T....Morin P.J. (2005)
Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer. (PubMed id 15240533)^{1, 3} Heinzelmann-Schwarz V.A....O'Brien P.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1365	HGNC: 2045	AceView: CLDN3	Ensembl:ENSG00000165215	euGenes: HUgn1365
ECgene: CLDN3	H-InvDB: CLDN3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for CLDN3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CLDN3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CLDN3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CLDN3		Antibodies for CLDN3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CLDN3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CLDN3)
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	Chimera RNAi (CLDN3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Claudin 3)
	Antibodies (Claudin 3)

Search OriGene for CLDN3

Search Tocris compounds for CLDN3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CLDN3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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CLDN3 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for CLDN3

Summaries
for CLDN3

Genomic Location
for CLDN3

Proteins
for CLDN3

Protein Domains/
Families
for CLDN3

Gene Function
for CLDN3

Pathways & Interactions
for CLDN3

Drugs & Compounds
for CLDN3

Transcripts
for CLDN3

Expression
for CLDN3

Orthologs
for CLDN3

Paralogs
for CLDN3

SNPs/Variants
for CLDN3

Disorders & Mutations
for CLDN3

Medical News
for CLDN3

Publications
for CLDN3

Search for CLDN3

Genome Databases showing CLDN3

Other Databases showing CLDN3

Specialized Databases showing CLDN3

Licensable Technologies
for CLDN3

Services
for CLDN3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CLDN3 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor CLDN3

Summariesfor CLDN3

Genomic Locationfor CLDN3

Proteinsfor CLDN3

Protein Domains/Familiesfor CLDN3

Gene Functionfor CLDN3

Pathways & Interactionsfor CLDN3

Drugs & Compoundsfor CLDN3

Transcriptsfor CLDN3

Expression for CLDN3

Orthologsfor CLDN3

Paralogsfor CLDN3

SNPs/Variantsfor CLDN3

Disorders & Mutationsfor CLDN3

Medical Newsfor CLDN3

Publicationsfor CLDN3

Search for CLDN3

Genome Databases showing CLDN3

Other Databases showing CLDN3

Specialized Databases showing CLDN3

Licensable Technologiesfor CLDN3

Servicesfor CLDN3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CLDN3

Summaries
for CLDN3

Genomic Location
for CLDN3

Proteins
for CLDN3

Protein Domains/
Families
for CLDN3

Gene Function
for CLDN3

Pathways & Interactions
for CLDN3

Drugs & Compounds
for CLDN3

Transcripts
for CLDN3

Expression
for CLDN3

Orthologs
for CLDN3

Paralogs
for CLDN3

SNPs/Variants
for CLDN3

Disorders & Mutations
for CLDN3

Medical News
for CLDN3

Publications
for CLDN3

Licensable Technologies
for CLDN3

Services
for CLDN3