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CLDN3 Gene

protein-coding   GIFtS: 61
GCID: GC07M073183

Claudin 3


(Previous symbols: C7orf1, CPETR2)
  See CLDN3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Claudin 31 2     CPE-R 22 3
CPETR21 2 3 5     CPE-R22
C7orf11 2 3     HRVP12
Clostridium Perfringens Enterotoxin Receptor 21 2 3     RVP12
CPE-Receptor 21 2 3     Ventral Prostate.1 Protein Homolog2
claudin-31 2     hRVP13
Ventral Prostate.1-Like Protein1 2     Rat Ventral Prostate.1 Protein Homolog3

External Ids:    HGNC: 20451   Entrez Gene: 13652   Ensembl: ENSG000001652157   OMIM: 6029105   UniProtKB: O155513   

Export aliases for CLDN3 gene to outside databases

Previous GC identifers: GC07M071823 GC07M072581 GC07M072595 GC07M072627 GC07M072821 GC07M069065


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLDN3 Gene:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming
continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely
through the paracellular space. These junctions are comprised of sets of continuous networking strands in the
outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet.
The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and
a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens
enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. (provided
by RefSeq, Jul 2008)

GeneCards Summary for CLDN3 Gene:
CLDN3 (claudin 3) is a protein-coding gene. Diseases associated with CLDN3 include pancreatoblastoma, and mucoepidermoid carcinoma. GO annotations related to this gene include transmembrane signaling receptor activity and identical protein binding. An important paralog of this gene is CLDN4.

UniProtKB/Swiss-Prot: CLD3_HUMAN, O15551
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLDN3 gene promoter:
         GR   Sp1   GR-beta   NRSF form 1   NRSF form 2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN3 promoter sequence
   Search Chromatin IP Primers for CLDN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11

CLDN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M073183:  view genomic region     (about GC identifiers)

Start:
73,183,327 bp from pter      End:
73,184,600 bp from pter
Size:
1,274 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 72,516,399-72,517,672     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLD3_HUMAN, O15551 (See protein sequence)
Recommended Name: Claudin-3  
Size: 220 amino acids; 23319 Da
Subunit: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2
homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity)

Explore the universe of human proteins at neXtProt for CLDN3: NX_O15551

Explore proteomics data for CLDN3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLDN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001297.1  
    ENSEMBL proteins: 
     ENSP00000378577  
    Reactome Protein details: O15551

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    Search eBioscience for ELISAs for CLDN3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR003549 Claudin3
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry O15551

    ProtoNet protein and cluster: O15551

    2 Blocks protein domains:
    IPB003549 Claudin-3 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD3_HUMAN, O15551
    Similarity: Belongs to the claudin family


    Find genes that share domains with CLDN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD3_HUMAN, O15551
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

         Genatlas biochemistry entry for CLDN3:
    claudin 3,clostridium perfringens enterotoxin receptor 2,low affinity,integral membrane protein,claudin family of
    major structural components of tight junction (TJ) strands,mainly expressed in lung and liver,also in kidney and
    testis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS9334247
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding IEA--
         
    Find genes that share ontologies with CLDN3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CLDN3:
     Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLDN3
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    1 qRT-PCR Assays for microRNA that regulate CLDN3:
    hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLDN3 3' UTR sequence
    Inhib. RNA
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    eBioscience FlowRNA Probe Sets ( VA1-12308) for CLDN3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLD3_HUMAN, O15551: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS9334247
    GO:0005923tight junction IEA--
    GO:0016021integral component of membrane TAS9441748

    Find genes that share ontologies with CLDN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLDN3 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    5Tight junction
    Tight junction


    Find genes that share SuperPaths with CLDN3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLDN3
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    2 GeneGo (Thomson Reuters) Pathways for CLDN3
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions


    1 Reactome Pathway for CLDN3
        Tight junction interactions


    4 Kegg Pathways  (Kegg details for CLDN3):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN3: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CLDN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLDN3 (O155513 ENSP000003785774) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    CLDN5O005013, ENSP000003845544I2D: score=2 STRING: ENSP00000384554
    PRKACAP176123, ENSP000003095914I2D: score=1 STRING: ENSP00000309591
    WNK4Q96J923, ENSP000002469144I2D: score=1 STRING: ENSP00000246914
    CLDN1O958323, ENSP000002955224I2D: score=2 STRING: ENSP00000295522
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEP15174142
    GO:0007165signal transduction TAS9334247
    GO:0016338calcium-independent cell-cell adhesion IEA--

    Find genes that share ontologies with CLDN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLDN3 (CLD3)

    1 HMDB Compound for CLDN3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 Novoseek inferred chemical compound relationships for CLDN3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    enterotoxin 72.2 7 18569027 (1), 20204275 (1), 17326053 (1), 9878248 (1) (see all 5)
    ochratoxin a 33.5 1 17499213 (1)
    cholesterol 0 5 17762176 (2), 15500448 (1)
    calcium 0 1 15305371 (1)
    vegf 0 4 15161682 (2)



    Find genes that share compounds with CLDN3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLDN3 gene: 
    NM_001306.3  

    Unigene Cluster for CLDN3:

    Claudin 3
    Hs.647023  [show with all ESTs]
    Unigene Representative Sequence: NM_001306
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000395145(uc003tzg.4)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CLDN3:
    hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLDN3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB000714.1 AK313276.1 BC009083.1 BC016056.1 

    7 DOTS entries:

    DT.117534  DT.92428811  DT.100780793  DT.100780801  DT.121098596  DT.91822771  DT.97856299 

    Selected AceView cDNA sequences (see all 412):

    BF569270 AW572988 AW572261 NM_001306 CA843928 AI739523 CB851892 BM764277 
    AW102853 BM967361 BF001523 AI281061 AW043573 BQ271070 AI318406 AW024873 
    AI698098 CB069656 AI347060 BU785571 CA942776 AI271338 AI222788 AI280872 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLDN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCGCGCTGG
    CLDN3 Expression
    About this image


    CLDN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Kidney (Urinary System)    fully expand to see all 7 entries
             Loop of Henle Cells Loop of Henle
             Renal Collecting Duct System
     
     Epithelial Cells
             Loop of Henle Cells Loop of Henle
     
     Head Mesenchyme (Muscoskeletal System)
             Frontonasal Process
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    CLDN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLDN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647023
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN3: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn31 , 5 claudin 31, 5 87.37(n)1
    91.32(a)1
      5 (74.93 cM)5
    127391  NM_009902.41  NP_034032.11 
     1349862145 
    chicken
    (Gallus gallus)
    Aves CLDN31 claudin 3 80.37(n)
    75.7(a)
      374029  NM_204202.1  NP_989533.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLDN36
    claudin 3
    72(a)
    1 ↔ 1
    GL343462.1(606419-607063)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cldn31 claudin 3 67.61(n)
    72.77(a)
      448229  NM_001005709.1  NP_001005709.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cldne2 claudin e 72.65(n)   81584  AF359425.1 


    ENSEMBL Gene Tree for CLDN3 (if available)
    TreeFam Gene Tree for CLDN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLDN3 gene
    CLDN42  CLDN92  CLDN82  CLDN202  CLDN172  CLDN52  CLDN22  CLDN12  
    CLDN142  CLDN62  CLDN72  CLDN192  
    Selected SIMAP similar genes for CLDN3 using alignment to 2 protein entries:     CLD3_HUMAN (see all proteins) (see all similar genes):
    CLDN4    CLDN9    CLDN6    CLDN7    CLDN17    CLDN2
    CLDN5    CLDN1    CLDN19    CLDN8    CLDN14    CLDN20
    CLDN18    CLDN10    CLDN15    CLDN22    CLDN24    CLDN25

    Find genes that share paralogs with CLDN3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLDN3 (see all 87)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107097221,2
    C--72516344(+) GCCCCG/-AGGGG 1 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs119798071,2
    C,F,A,H--76708359(+) TTTTCT/GTTTTT 1 -- int121Minor allele frequency- G:0.47NS EA NA WA CSA 2344
    rs1861874531,2
    --76708368(+) TTCCAA/CTAGGA 1 -- int10--------
    rs1919524371,2
    --76708440(+) TTGTGC/TGGGGT 1 -- int10--------
    rs11299651,2
    C--76708889(-) CCCTTC/TTGGAG 1 -- ut312Minor allele frequency- T:0.00MN NA 186
    rs1444966091,2
    --76708909(+) ACAGTC/GCATGC 1 -- ut310--------
    rs1484440021,2
    C,F--76709137(+) CCTTAG/AACGTA 2 /V syn12Minor allele frequency- A:0.00NA EU 4461
    rs1431155321,2
    F--76709266(+) AGCGCG/TCCCCC 2 G syn11Minor allele frequency- T:0.00NA 2672
    rs626377061,2
    C,F--76709305(+) CCCACG/ATACAG 2 /Y syn14Minor allele frequency- A:0.04NS WA CSA 178
    rs1391913281,2
    C,F--76709396(+) ACACCG/AGCACG 2 /P /L mis12Minor allele frequency- A:0.00NA EU 4835

    HapMap Linkage Disequilibrium report for CLDN3 (73183327 - 73184600 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CLDN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5791CNV Insertion18451855
    nsv831028CNV Loss17160897
    nsv831029CNV Loss17160897
    nsv469841CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602910    OMIM disorders: --

    UniProtKB/Swiss-Prot: CLD3_HUMAN, O15551
  • Note=CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a
    hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing
    over between highly homologous low-copy repeat sequences flanking the deleted region

  • 7 diseases for CLDN3:    
    About MalaCards
    pancreatoblastoma    mucoepidermoid carcinoma    ovarian cystadenoma    molybdenum cofactor deficiency
    malignant peritoneal mesothelioma    endometrial carcinoma    ovarian cancer

    2 diseases from the University of Copenhagen DISEASES database for CLDN3:
    Ovarian cancer     Carcinoma

    Find genes that share disorders with CLDN3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CLDN3 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian carcinoma 58.6 9 17647191 (4), 19567823 (2), 12855632 (1), 17509990 (1)
    ovarian cancer 55.1 23 15905176 (4), 17986852 (3), 19567823 (3), 15899825 (3) (see all 10)
    carcinoma papillary 51.3 3 19426958 (2), 17326053 (1)
    endometrial cancer 43.1 9 18313739 (5), 17326053 (1)
    adenocarcinoma 42.6 16 16287068 (2), 17647191 (2), 16540726 (2), 17509990 (2) (see all 9)
    tumors 42.5 24 12855632 (2), 19082451 (1), 17647191 (1), 15067357 (1) (see all 19)
    carcinoma 38.2 3 16797678 (1), 17647191 (1), 17804705 (1)
    gastric carcinoma 36.2 2 18251778 (2)
    prostatic adenocarcinoma 35.1 3 11691807 (1), 18097572 (1)
    metaplasia 34.2 2 16540726 (1), 17103306 (1)


    Export disorders for CLDN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLDN3 gene, integrated from 10 sources (see all 157):
    (articles sorted by number of sources associating them with CLDN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of a human gene homologous to rat ventral prostate.1 protein. (PubMed id 9441748)1, 2, 3, 9 Peacock R.E.... Inglehearn C.F. (Genomics 1997)
    2. Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. (PubMed id 9334247)1, 2, 9 Katahira J....Sugimoto N. (J. Biol. Chem. 1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    5. Regulation of the CLDN3 gene in ovarian cancer cells. (PubMed id 17986852)1, 9 Honda H....Morin P.J. (amp 2007)
    6. Altered expression of claudin-3 and claudin-4 in ectopic endometrium of women with endometriosis. (PubMed id 18384777)1, 9 Pan X.Y....Wang B. (Fertil. Steril. 2009)
    7. Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer. (PubMed id 18313739)1, 9 Konecny G.E....Podratz K.C. (Gynecol. Oncol. 2008)
    8. Expression profile of tight junction protein claudin 3 and claudin 4 in ovarian serous adenocarcinoma with prognostic correlation. (PubMed id 17647191)1, 9 Choi Y.L....Shin Y.K. (Histol. Histopathol. 2007)
    9. Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. (PubMed id 15905176)1, 9 D'Souza T.... Morin P.J. (J. Biol. Chem. 2005)
    10. Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer. (PubMed id 15240533)1, 9 Heinzelmann-Schwarz V.A....O'Brien P.M. (Clin. Cancer Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1365 HGNC: 2045 AceView: CLDN3 Ensembl:ENSG00000165215 euGenes: HUgn1365
    ECgene: CLDN3 Kegg: 1365 H-InvDB: CLDN3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CLDN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CLDN3 gene:
    Search GeneIP for patents involving CLDN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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