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Aliases for CLDN25 Gene

Aliases for CLDN25 Gene

  • Claudin 25 2 3

External Ids for CLDN25 Gene

Previous GeneCards Identifiers for CLDN25 Gene

  • GC11P113158
  • GC11P113650
  • GC11P109579

Summaries for CLDN25 Gene

Entrez Gene Summary for CLDN25 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010]

GeneCards Summary for CLDN25 Gene

CLDN25 (Claudin 25) is a Protein Coding gene. Among its related pathways are Leukocyte transendothelial migration and Hepatitis C. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is CLDN15.

UniProtKB/Swiss-Prot for CLDN25 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN25 Gene

Genomics for CLDN25 Gene

Genomic Location for CLDN25 Gene

113,779,747 bp from pter
113,780,500 bp from pter
754 bases
Plus strand

Genomic View for CLDN25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLDN25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN25 Gene

No data available for Regulatory Elements for CLDN25 Gene

Proteins for CLDN25 Gene

  • Protein details for CLDN25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative claudin-25
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CLDN25 Gene

    229 amino acids
    Molecular mass:
    25394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN25 Gene

Proteomics data for CLDN25 Gene at MOPED

Post-translational modifications for CLDN25 Gene

No Post-translational modifications

Other Protein References for CLDN25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN25 Gene

Domains for CLDN25 Gene

Gene Families for CLDN25 Gene

Protein Domains for CLDN25 Gene


Suggested Antigen Peptide Sequences for CLDN25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the claudin family.
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN25: view

Function for CLDN25 Gene

Molecular function for CLDN25 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with CLDN25: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN25

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN25 Gene

Localization for CLDN25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN25 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CLDN25 Gene COMPARTMENTS Subcellular localization image for CLDN25 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CLDN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLDN25: view

Pathways for CLDN25 Gene

genes like me logo Genes that share pathways with CLDN25: view

Pathways by source for CLDN25 Gene

Interacting Proteins for CLDN25 Gene

Gene Ontology (GO) - Biological Process for CLDN25 Gene


Transcripts for CLDN25 Gene

mRNA/cDNA for CLDN25 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN25

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN25 Gene

No ASD Table

Relevant External Links for CLDN25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLDN25 Gene

mRNA expression in normal human tissues for CLDN25 Gene

mRNA differential expression in normal tissues according to GTEx for CLDN25 Gene

This gene is overexpressed in Pituitary (22.4), Muscle - Skeletal (8.8), Testis (5.4), Skin - Sun Exposed (Lower leg) (5.0), and Liver (4.4).

SOURCE GeneReport for Unigene cluster for CLDN25 Gene Hs.705360

genes like me logo Genes that share expressions with CLDN25: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for CLDN25 Gene

Orthologs for CLDN25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN25 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLDN25 35
  • 85.74 (n)
  • 81.66 (a)
CLDN25 36
  • 82 (a)
(Canis familiaris)
Mammalia CLDN25 35
  • 86.11 (n)
  • 82.46 (a)
CLDN25 36
  • 82 (a)
(Pan troglodytes)
Mammalia CLDN25 35
  • 99.42 (n)
  • 99.13 (a)
CLDN25 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100360390 35
  • 80.79 (n)
  • 76.42 (a)
(Monodelphis domestica)
Mammalia CLDN25 36
  • 59 (a)
(Mus musculus)
Mammalia Cldn13 36
  • 27 (a)
(Gallus gallus)
Aves CLDN25 35
  • 59.1 (n)
  • 51.53 (a)
CLDN25 36
  • 51 (a)
(Anolis carolinensis)
Reptilia CLDN25 36
  • 43 (a)
(Danio rerio)
Actinopterygii CLDN22 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
CSA.10090 36
  • 25 (a)
Species with no ortholog for CLDN25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN25 Gene

Gene Tree for CLDN25 (if available)
Gene Tree for CLDN25 (if available)

Paralogs for CLDN25 Gene

Paralogs for CLDN25 Gene

(13) SIMAP similar genes for CLDN25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLDN25: view

Variants for CLDN25 Gene

Sequence variations from dbSNP and Humsavar for CLDN25 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7105485 -- 113,778,978(+) taagc(A/G)gcttg upstream-variant-2KB
rs7129831 -- 113,780,678(+) TTTTC(G/T)GATTT downstream-variant-500B
rs11269234 -- 113,778,820(+) GCACA(-/CACACACGCACA)TATTT upstream-variant-2KB
rs17115958 -- 113,779,918(+) CTGAA(C/T)GAGAT reference, synonymous-codon
rs34017209 -- 113,779,129(+) TTACA(A/G)GCATG upstream-variant-2KB

Relevant External Links for CLDN25 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CLDN25 Gene

Disorders for CLDN25 Gene

No disorders were found for CLDN25 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CLDN25 Gene

Publications for CLDN25 Gene

  1. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3
  2. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PMID: 12736707) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 3
  3. Structure and function of claudins. (PMID: 18036336) Krause G. … Blasig I.E. (Biochim. Biophys. Acta 2008) 3
  4. The claudins. (PMID: 19706201) Lal-Nag M. … Morin P.J. (Genome Biol. 2009) 3
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for CLDN25 Gene

Sources for CLDN25 Gene

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