CLDN25 Gene
protein-coding GIFtS: 31
GCID: GC11P113650
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claudin 25
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Aliases
for CLDN25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Claudin 251 2 | | Putative Claudin-252 |
Export aliases for CLDN25 gene to outside databasesPrevious GC identifers: GC11P113158 GC11P109579 |
Summaries
for CLDN25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CLDN25:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tightjunction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freelythrough the paracellular space between epithelial or endothelial cell sheets, and also play critical roles inmaintaining cell polarity and signal transductions. (provided by RefSeq, Jun 2010)
UniProtKB/Swiss-Prot: CLD25_HUMAN, C9JDP6Function: Plays a major role in tight junction-specific obliteration of the intercellular space, throughcalcium-independent cell-adhesion activity (By similarity)
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Genomic Views
for CLDN25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CLDN25
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLDN25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.2 Ensembl cytogenetic band: 11q23.2 HGNC cytogenetic band: 11q23.2CLDN25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P113650: view genomic region
(about GC identifiers)
Start:
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113,650,469 bp from pter |
End:
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113,651,222 bp from pter |
Size:
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754 bases |
Orientation:
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plus strand |
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Proteins
for CLDN25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLD25_HUMAN, C9JDP6 (See
protein sequence)Recommended Name: Putative claudin-25 Size: 229 amino acids; 25394 Da
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (Bysimilarity)
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for CLDN25: NX_C9JDP6
CLDN25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001094859.1
ENSEMBL proteins: ENSP00000396304
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CLDN25 for ontologies About GeneDecksing
CLDN25 Antibody Products:
Assay Products for CLDN25: |
Protein
Domains /
Families
for CLDN25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLDN25 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry C9JDP6ProtoNet protein and cluster: C9JDP6 UniProtKB/Swiss-Prot: CLD25_HUMAN, C9JDP6Similarity: Belongs to the claudin family |
Function
for CLDN25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CLD25_HUMAN, C9JDP6Function: Plays a major role in tight junction-specific obliteration of the intercellular space, throughcalcium-independent cell-adhesion activity (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN25
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN25
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: CLDN25 (NM_001101389) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN25 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- |
CLDN25 for ontologies About GeneDecksing
|
Pathways & Interactions
for CLDN25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN25
|
Drugs & Compounds
for CLDN25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CLDN25
Search CenterWatch for drugs/clinical trials and news about CLDN25 / CLD25
|
Transcripts
for CLDN25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLDN25 gene: NM_001101389.1 Unigene Cluster for CLDN25: Claudin 25 Hs.705360 Unigene Representative Sequence: NM_0011013891 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000453129(uc009yyw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN25
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN25
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CLDN25 (NM_001101389) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLDN25 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLDN25 |
GeneLoc Exon Structure
|
Expression
for CLDN25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLDN25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAAGACCTA
About this image
See CLDN25 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.705360
SABiosciences Custom PCR Arrays for CLDN25
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN25
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CLDN25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN25 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN25 |
Orthologs
for CLDN25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CLDN25 gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for CLDN25 (if available)
TreeFam Gene Tree for CLDN25 (if available) |
Paralogs
for CLDN25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLDN25 gene
- CLDN182 CLDN242 CLDN222
14 SIMAP similar genes for CLDN25 using alignment to 1 protein entry: CLD25_HUMAN:CLDN22 CLDN24 CLDN8 CLDN14 CLDN17 CLDN1
CLDN2 CLDN4 CLDN3 CLDN5 CLDN6 CLDN9
CLDN7 CLDN19
CLDN25 for paralogs About GeneDecksing
|
Genomic Variants
for CLDN25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLDN25 (113650469 - 113651222 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLDN25: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN25 |
|
Disorders
/ Diseases
for CLDN25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLDN25 for disorders About GeneDecksing
1  disease for CLDN25: About MalaCardsgastric cancer
Export disorders for CLDN25 gene to outside databases
|
Publications
for CLDN25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLDN25 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLDN25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The claudins. (PubMed id 19706201)1 Lal-Nag M. and Morin P.J. (2009)
- Structure and function of claudins. (PubMed id 18036336)1 Krause G....Blasig I.E. (2008)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PubMed id 12736707)1 Katoh M. and Katoh M. (2003)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
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External Searches for CLDN25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CLDN25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLDN25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLDN25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLDN25 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CLDN25 gene:
Search GeneIP for patents involving CLDN25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLDN25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLDN25 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN25 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN25 | | | OriGene Protein Over-expression Lysate for CLDN25 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLDN25 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN25 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN25 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLDN25 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN25 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN25 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN25 |
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 |  |  |  | |
| | | | Search Tocris compounds for CLDN25 |
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 | | | CLDN25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN25 |
|  |  |  | | | | Search ThermoFisher Antibodies for CLDN25 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLDN25 |
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