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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN25 Gene

protein-coding   GIFtS: 35
GCID: GC11P113650

Claudin 25

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Claudin 251 2
Putative Claudin-252

External Ids:    HGNC: 372181   Entrez Gene: 6446722   Ensembl: ENSG000002286077   UniProtKB: C9JDP63   

Export aliases for CLDN25 gene to outside databases

Previous GC identifers: GC11P113158 GC11P109579


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLDN25 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. (provided by RefSeq, Jun 2010)

GeneCards Summary for CLDN25 Gene: 
CLDN25 (claudin 25) is a protein-coding gene. Diseases associated with CLDN25 include endotheliitis, and gastric cancer. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is CLDN18.

UniProtKB/Swiss-Prot: CLD25_HUMAN, C9JDP6
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CLDN25
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q23.2

CLDN25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN25 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P113650:  view genomic region     (about GC identifiers)

Start:
113,650,469 bp from pter      End:
113,651,222 bp from pter
Size:
754 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLD25_HUMAN, C9JDP6 (See protein sequence)
Recommended Name: Putative claudin-25  
Size: 229 amino acids; 25394 Da
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein
(By similarity)
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for CLDN25: NX_C9JDP6

CLDN25 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001094859.1  
ENSEMBL proteins: 
 ENSP00000396304  

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0005923tight junction IEA--
GO:0016021integral to membrane IEA--

CLDN25 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro protein domains:
 IPR006187 Claudin
 IPR004031 PMP22/EMP/MP20/Claudin

Graphical View of Domain Structure for InterPro Entry C9JDP6

ProtoNet protein and cluster: C9JDP6

UniProtKB/Swiss-Prot: CLD25_HUMAN, C9JDP6
Similarity: Belongs to the claudin family


CLDN25 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CLD25_HUMAN, C9JDP6
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005198structural molecule activity IEA--
     
CLDN25 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CLDN25 About                                                                                                See pathways by source

SuperPathContained pathways About
1Leukocyte transendothelial migration
Leukocyte transendothelial migration
2Hepatitis C
Hepatitis C
3Cell adhesion molecules (CAMs)
Cell adhesion molecules (CAMs)
4Tight junction
Tight junction

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



4         Kegg Pathways  (Kegg details for CLDN25):
    Cell adhesion molecules (CAMs)
Tight junction
Leukocyte transendothelial migration
Hepatitis C


CLDN25 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN25

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLDN25 (CLD25)

Search CenterWatch for drugs/clinical trials and news about CLDN25 / CLD25

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLDN25 gene: 
NM_001101389.1  

Unigene Cluster for CLDN25:

Claudin 25
Hs.705360
Unigene Representative Sequence: NM_001101389
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000453129(uc009yyw.1)
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLDN25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTAAGACCTA
CLDN25 Expression
About this image


SOURCE GeneReport for Unigene cluster: Hs.705360
    SABiosciences Custom PCR Arrays for CLDN25
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN25

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CLDN25 gene from 3/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves CLDN251 claudin 25 59.1(n)
51.53(a)
  428245  XM_425804.3  XP_425804.3 
lizard
(Anolis carolinensis)
Reptilia CLDN256
Uncharacterized protein
43(a)
1 ↔ 1
GL343354.1(260845-261495)
zebrafish
(Danio rerio)
Actinopterygii CLDN226
CABZ01080075.16
(see all 5)
Uncharacterized protein
(see all 5)
35(a)
32(a)
(see all 5)
1 ↔ many
possible ortholog
(see all 5)
5(13915604-13916266)
11(45262734-45263381)
        Species with no ortholog for CLDN25

ENSEMBL Gene Tree for CLDN25 (if available)
TreeFam Gene Tree for CLDN25 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CLDN25 gene
CLDN182  CLDN242  CLDN222  
13 SIMAP similar genes for CLDN25 using alignment to 1 protein entry:     CLD25_HUMAN:
CLDN22    CLDN24    CLDN8    CLDN14    CLDN17    CLDN1
CLDN2    CLDN4    CLDN3    CLDN5    CLDN6    CLDN9
CLDN7

CLDN25 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/91 SNPs in CLDN25 are shown (see all 91)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1450954861,2
--109577048(+) TATGAC/TGTAGA 1 -- us2k10--------
rs1872875681,2
--113648525(+) TTCACA/GTGTTT 1 -- us2k10--------
rs1910826241,2
--113648629(+) GGTGCC/TGGTGC 1 -- us2k10--------
rs759809841,2
C--113648702(+) CTGTGC/TCTTAT 1 -- us2k10--------
rs1405751501,2
--113648855(+) GGGAAA/GCACAT 1 -- us2k10--------
rs1815393981,2
--113648913(+) GTCTCA/GCTATA 1 -- us2k10--------
rs1504406601,2
--113649105(+) AAATAC/TGGATA 1 -- us2k10--------
rs1381302261,2
--113649144(+) GCCGTA/GCTCAG 1 -- us2k10--------
rs1129874221,2
F--113649145(+) CCGTAC/GTCAGT 1 -- us2k12Minor allele frequency- G:0.04CSA WA 120
rs1160474341,2
F--113649148(+) TACTCA/TGTAAA 1 -- us2k11Minor allele frequency- T:0.03WA 118

HapMap Linkage Disequilibrium report for CLDN25 (113650469 - 113651222 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for CLDN25: --
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for CLDN25:    About MalaCards
endotheliitis    gastric cancer


CLDN25 for disorders           About GeneDecksing


Export disorders for CLDN25 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CLDN25 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLDN25)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The claudins. (PubMed id 19706201)1 Lal-Nag M. and Morin P.J. (2009)
  2. Structure and function of claudins. (PubMed id 18036336)1 Krause G....Blasig I.E. (2008)
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
  4. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PubMed id 12736707)1 Katoh M. and Katoh M. (2003)
  5. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 644672 HGNC: 37218 Ensembl:ENSG00000228607 euGenes: HUgn644672 ECgene: CLDN25 Kegg: 644672
H-InvDB: CLDN25

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CLDN25 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CLDN25 gene:
Search GeneIP for patents involving CLDN25

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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About This Section

 
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 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLDN25
 inGenious Targeting Laboratory - Custom generated mouse model solutions for CLDN25
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLDN25
Customized:
 lentivirus for stable overexpression of CLDN25
 lentivirus expression plasmids for stable overexpression of CLDN25
 adenovirus for overexpression of CLDN25
 LSBio Antibodies in human, mouse, rat for CLDN25
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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