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Aliases for CLDN24 Gene

Aliases for CLDN24 Gene

  • Claudin 24 2 3
  • Claudin 21 2 3
  • Putative Claudin-24 3
  • CLDN21 3

External Ids for CLDN24 Gene

Previous HGNC Symbols for CLDN24 Gene

  • CLDN21

Previous GeneCards Identifiers for CLDN24 Gene

  • GC04M184480
  • GC04M184242
  • GC04M180003

Summaries for CLDN24 Gene

Entrez Gene Summary for CLDN24 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is 75% identical to the mouse homolog. This gene is upstream of the CLDN22 gene, which overlaps the WWC2 gene on the opposite strand in the genome.[provided by RefSeq, Aug 2010]

GeneCards Summary for CLDN24 Gene

CLDN24 (Claudin 24) is a Protein Coding gene. Among its related pathways are Leukocyte transendothelial migration and Hepatitis C. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is CLDN15.

UniProtKB/Swiss-Prot for CLDN24 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN24 Gene

Genomics for CLDN24 Gene

Regulatory Elements for CLDN24 Gene

Genomic Location for CLDN24 Gene

Start:
183,321,764 bp from pter
End:
183,322,426 bp from pter
Size:
663 bases
Orientation:
Minus strand

Genomic View for CLDN24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLDN24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN24 Gene

Proteins for CLDN24 Gene

  • Protein details for CLDN24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NM45-CLD24_HUMAN
    Recommended name:
    Putative claudin-24
    Protein Accession:
    A6NM45
    Secondary Accessions:
    • F5H040

    Protein attributes for CLDN24 Gene

    Size:
    220 amino acids
    Molecular mass:
    24421 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN24 Gene

Proteomics data for CLDN24 Gene at MOPED

Post-translational modifications for CLDN24 Gene

No Post-translational modifications

Other Protein References for CLDN24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN24 Gene

Domains for CLDN24 Gene

Protein Domains for CLDN24 Gene

Suggested Antigen Peptide Sequences for CLDN24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NM45

UniProtKB/Swiss-Prot:

CLD24_HUMAN :
  • A6NM45
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN24: view

No data available for Gene Families for CLDN24 Gene

Function for CLDN24 Gene

Molecular function for CLDN24 Gene

UniProtKB/Swiss-Prot Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with CLDN24: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLDN24 Gene

Localization for CLDN24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN24 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDN24 Gene COMPARTMENTS Subcellular localization image for CLDN24 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CLDN24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLDN24: view

Pathways for CLDN24 Gene

genes like me logo Genes that share pathways with CLDN24: view

Pathways by source for CLDN24 Gene

Interacting Proteins for CLDN24 Gene

Gene Ontology (GO) - Biological Process for CLDN24 Gene

None

Compounds for CLDN24 Gene

(1) HMDB Compounds for CLDN24 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CLDN24: view

Transcripts for CLDN24 Gene

mRNA/cDNA for CLDN24 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN24

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN24 Gene

No ASD Table

Relevant External Links for CLDN24 Gene

GeneLoc Exon Structure for
CLDN24
ECgene alternative splicing isoforms for
CLDN24

Expression for CLDN24 Gene

mRNA expression in normal human tissues for CLDN24 Gene

SOURCE GeneReport for Unigene cluster for CLDN24 Gene Hs.727475

genes like me logo Genes that share expressions with CLDN24: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for CLDN24 Gene

Orthologs for CLDN24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLDN24 36
  • 96 (a)
OneToOne
LOC100609738 35
  • 97.73 (n)
  • 96.36 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 78 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
CLDN24 35
  • 80 (n)
  • 78.18 (a)
mouse
(Mus musculus)
Mammalia Cldn22 36
  • 72 (a)
ManyToMany
Cldn24 35
  • 79.55 (n)
  • 75.91 (a)
Cldn24 16
Cldn24 36
  • 76 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CLDN22 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
ManyToMany
CSA.10090 36
  • 30 (a)
ManyToMany
Species with no ortholog for CLDN24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN24 Gene

ENSEMBL:
Gene Tree for CLDN24 (if available)
TreeFam:
Gene Tree for CLDN24 (if available)

Paralogs for CLDN24 Gene

Paralogs for CLDN24 Gene

Selected SIMAP similar genes for CLDN24 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLDN24: view

Variants for CLDN24 Gene

Sequence variations from dbSNP and Humsavar for CLDN24 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs12647658 -- 183,324,134(+) GGCAT(C/T)TAAGC upstream-variant-2KB
rs35781678 -- 183,323,226(+) TTTCA(G/T)CAGCT upstream-variant-2KB
rs73872367 -- 183,323,414(+) GACCG(A/G)CCTCA upstream-variant-2KB
rs73872368 -- 183,323,821(+) CTCTT(C/T)CTTAA upstream-variant-2KB
rs114235895 -- 183,322,852(+) ATCTG(A/T)AATTT upstream-variant-2KB

Relevant External Links for CLDN24 Gene

HapMap Linkage Disequilibrium report
CLDN24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CLDN24 Gene

Disorders for CLDN24 Gene

No disorders were found for CLDN24 Gene.

No data available for UniProtKB/Swiss-Prot for CLDN24 Gene

Publications for CLDN24 Gene

  1. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PMID: 12736707) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 3
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Structure and function of claudins. (PMID: 18036336) Krause G. … Blasig I.E. (Biochim. Biophys. Acta 2008) 3
  4. The claudins. (PMID: 19706201) Lal-Nag M. … Morin P.J. (Genome Biol. 2009) 3
  5. Tight junctions of the blood-brain barrier. (PMID: 10690502) Kniesel U. … Wolburg H. (Cell. Mol. Neurobiol. 2000) 3

Products for CLDN24 Gene

Sources for CLDN24 Gene

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