CLDN24 Gene
protein-coding GIFtS: 31
GCID: GC04M184242
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claudin 24(Previous name: claudin 21 )
(Previous symbol: CLDN21)
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Aliases
for CLDN24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Claudin 241 2 | | CLDN211 2 | | Claudin 211 2 | | Putative Claudin-242 |
Export aliases for CLDN24 gene to outside databasesPrevious GC identifers: GC04M184480 GC04M180003 |
Summaries
for CLDN24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CLDN24:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tightjunction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freelythrough the paracellular space between epithelial or endothelial cell sheets, and also play critical roles inmaintaining cell polarity and signal transductions. The protein encoded by this gene is 75% identical to the mousehomolog. This gene is upstream of the CLDN22 gene, which overlaps the WWC2 gene on the opposite strand in thegenome.(provided by RefSeq, Aug 2010)
UniProtKB/Swiss-Prot: CLD24_HUMAN, A6NM45Function: Plays a major role in tight junction-specific obliteration of the intercellular space, throughcalcium-independent cell-adhesion activity (By similarity)
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Genomic Views
for CLDN24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLDN24 gene promoter:
FOXD3 AP-2gamma C/EBPalpha Evi-1 E47 AP-2beta Hand1 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLDN24
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN24 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q35.1 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q35.1CLDN24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M184242: view genomic region
(about GC identifiers)
Start:
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184,242,917 bp from pter |
End:
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184,243,579 bp from pter |
Size:
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663 bases |
Orientation:
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minus strand |
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Proteins
for CLDN24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLD24_HUMAN, A6NM45 (See
protein sequence)Recommended Name: Putative claudin-24 Size: 205 amino acids; 22802 Da
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (Bysimilarity)
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for CLDN24: NX_A6NM45
CLDN24 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001172078.1
ENSEMBL proteins: ENSP00000422519 ENSP00000438400
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CLDN24 for ontologies About GeneDecksing
CLDN24 Antibody Products:
Assay Products for CLDN24: |
Protein
Domains /
Families
for CLDN24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLDN24 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NM45ProtoNet protein and cluster: A6NM45 UniProtKB/Swiss-Prot: CLD24_HUMAN, A6NM45Similarity: Belongs to the claudin family |
Function
for CLDN24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CLD24_HUMAN, A6NM45Function: Plays a major role in tight junction-specific obliteration of the intercellular space, throughcalcium-independent cell-adhesion activity (By similarity)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN24 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005198 | structural molecule activity |
IEA | -- |
CLDN24 for ontologies About GeneDecksing
|
Pathways & Interactions
for CLDN24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN24
|
Drugs & Compounds
for CLDN24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CLDN24
1 HMDB Compound for CLDN24 About this table
Search CenterWatch for drugs/clinical trials and news about CLDN24 / CLD24 
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Transcripts
for CLDN24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLDN24 gene: NM_001185149.1 Unigene Cluster for CLDN24: Claudin 24 Hs.727475 Unigene Representative Sequence: NM_0011851492 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000514470 ENST00000541814(uc021xva.1)
GeneLoc Exon Structure
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Expression
for CLDN24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLDN24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.727475
SABiosciences Custom PCR Arrays for CLDN24
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CLDN24 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN24 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN24 |
Orthologs
for CLDN24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CLDN24 gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for CLDN24 (if available)
TreeFam Gene Tree for CLDN24 (if available) |
Paralogs
for CLDN24 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLDN24 gene
- CLDN182 CLDN252 CLDN222
18 SIMAP similar genes for CLDN24 using alignment to 3 protein entries: CLD24_HUMAN (see all proteins):CLDN22 CLDN25 CLDN8 CLDN14 CLDN17 CLDN1
CLDN2 CLDN4 CLDN6 CLDN9 CLDN7 CLDN20
CLDN3 CLDN10 CLDN19 CLDN5 CLDN15 CLDN18
CLDN24 for paralogs About GeneDecksing
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Genomic Variants
for CLDN24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN24 |
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Disorders
/ Diseases
for CLDN24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLDN24 for disorders About GeneDecksing
2  diseases for CLDN24: About MalaCardsteratocarcinoma gastric cancer
Export disorders for CLDN24 gene to outside databases
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Publications
for CLDN24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLDN24 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLDN24) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PubMed id 12736707)1, 3 Katoh M. and Katoh M. (2003)
- The claudins. (PubMed id 19706201)1 Lal-Nag M. and Morin P.J. (2009)
- Structure and function of claudins. (PubMed id 18036336)1 Krause G....Blasig I.E. (2008)
- Tight junction proteins. (PubMed id 12475568)1 Gonzalez-Mariscal L....Jaramillo B.E. (2003)
- Claudin-based barrier in simple and stratified cellular sheets. (PubMed id 12231346)1 Tsukita S. and Furuse M. (2002)
- The roles of claudin superfamily proteins in paracellular transport. (PubMed id 11247307)1 Heiskala M....Yang Y. (2001)
- Multifunctional strands in tight junctions. (PubMed id 11283726)1 Tsukita S....Itoh M. (2001)
- Tight junctions of the blood-brain barrier. (PubMed id 10690502)1 Kniesel U. and Wolburg H. (2000)
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External Searches for CLDN24 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CLDN24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLDN24 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLDN24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLDN24 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CLDN24 gene:
Search GeneIP for patents involving CLDN24
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLDN24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLDN24 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN24 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN24 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN24 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN24 |
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| | | | Search Tocris compounds for CLDN24 |
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 | | | CLDN24 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN24 |
|  |  |  | | | | Search ThermoFisher Antibodies for CLDN24 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLDN24 |
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