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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN24 Gene

protein-coding   GIFtS: 33
GCID: GC04M184242

Claudin 24

(Previous name: claudin 21)
(Previous symbol: CLDN21)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Claudin 241 2
CLDN211 2
Claudin 211 2
Putative Claudin-242

External Ids:    HGNC: 372001   Entrez Gene: 1001324632   Ensembl: ENSG000001857587   UniProtKB: A6NM453   

Export aliases for CLDN24 gene to outside databases

Previous GC identifers: GC04M184480 GC04M180003


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLDN24 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. The protein encoded by this gene is 75% identical to the
mouse homolog. This gene is upstream of the CLDN22 gene, which overlaps the WWC2 gene on the opposite strand in
the genome.(provided by RefSeq, Aug 2010)

GeneCards Summary for CLDN24 Gene: 
CLDN24 (claudin 24) is a protein-coding gene. Diseases associated with CLDN24 include teratocarcinoma, and endotheliitis. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is CLDN18.

UniProtKB/Swiss-Prot: CLD24_HUMAN, A6NM45
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN24 gene promoter:
         FOXD3   AP-2gamma   C/EBPalpha   Evi-1   E47   AP-2beta   Hand1   AP-2alpha   AP-2alphaA   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35.1

CLDN24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN24 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M184242:  view genomic region     (about GC identifiers)

Start:
184,242,917 bp from pter      End:
184,243,579 bp from pter
Size:
663 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLD24_HUMAN, A6NM45 (See protein sequence)
Recommended Name: Putative claudin-24  
Size: 220 amino acids; 24421 Da
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein
(By similarity)
Caution: Could be the product of a pseudogene
Secondary accessions: F5H040

Explore the universe of human proteins at neXtProt for CLDN24: NX_A6NM45

CLDN24 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001172078.1  
ENSEMBL proteins: 
 ENSP00000422519   ENSP00000438400  

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0005923tight junction IEA--
GO:0016021integral to membrane IEA--

CLDN24 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR017974 Claudin_CS
 IPR006187 Claudin
 IPR004031 PMP22/EMP/MP20/Claudin

Graphical View of Domain Structure for InterPro Entry A6NM45

ProtoNet protein and cluster: A6NM45

UniProtKB/Swiss-Prot: CLD24_HUMAN, A6NM45
Similarity: Belongs to the claudin family


CLDN24 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CLD24_HUMAN, A6NM45
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005198structural molecule activity IEA--
     
CLDN24 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CLDN24 About                                                                                                See pathways by source

SuperPathContained pathways About
1Leukocyte transendothelial migration
Leukocyte transendothelial migration
2Hepatitis C
Hepatitis C
3Cell adhesion molecules (CAMs)
Cell adhesion molecules (CAMs)
4Tight junction
Tight junction

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



4         Kegg Pathways  (Kegg details for CLDN24):
    Cell adhesion molecules (CAMs)
Tight junction
Leukocyte transendothelial migration
Hepatitis C


CLDN24 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN24

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for CLDN24 (CLD24)

1 HMDB Compound for CLDN24    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

Search CenterWatch for drugs/clinical trials and news about CLDN24 / CLD24

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLDN24 gene: 
NM_001185149.1  

Unigene Cluster for CLDN24:

Claudin 24
Hs.727475
Unigene Representative Sequence: NM_001185149
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000514470 ENST00000541814(uc021xva.1)
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLDN24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CLDN24 Expression
About this image


SOURCE GeneReport for Unigene cluster: Hs.727475
    SABiosciences Custom PCR Arrays for CLDN24
Primer
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SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CLDN24
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN24

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CLDN24 gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cldn241 , 5 claudin 241, 5 79.55(n)1
75.91(a)1
  8 (26.91 cM)5
1000398011  NM_001111318.11  NP_001104788.11 
 478221435 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
70(a)
1 → many
4(39326001-39326654)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
68(a)
1 → many
5(113896649-113897263)
zebrafish
(Danio rerio)
Actinopterygii LOC7931431 novel protein similar to human claudin 22 (CLDN22) 54.39(n)
45.45(a)
  793143  NM_001122706.1  NP_001116178.1 


ENSEMBL Gene Tree for CLDN24 (if available)
TreeFam Gene Tree for CLDN24 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CLDN24 gene
CLDN182  CLDN252  CLDN222  
18 SIMAP similar genes for CLDN24 using alignment to 2 protein entries:     CLD24_HUMAN (see all proteins):
CLDN22    CLDN25    CLDN8    CLDN14    CLDN17    CLDN1
CLDN2    CLDN4    CLDN9    CLDN20    CLDN3    CLDN6
CLDN7    CLDN10    CLDN19    CLDN5    CLDN15    CLDN18

CLDN24 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/30 SNPs in CLDN24 are shown (see all 30)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0556604
----see VAR_0556602 L F mis40--------
rs1142358951,2
F--184244005(+) ATCTGA/TAATTT 1 -- us2k11Minor allele frequency- T:0.01WA 118
rs1402493341,2
C--184244061(+) TATAA-/TCTCTAT 1 -- us2k10--------
rs1502679401,2
--184244156(+) CTCGGA/TTTCCT 1 -- us2k10--------
rs1858619331,2
--184244290(+) CCATCC/GTCGTT 1 -- us2k10--------
rs1389791591,2
--184244315(+) AAAGCA/TTGATA 1 -- us2k10--------
rs1402124121,2
C--184244341(+) AGGTG-/TTTTTT 1 -- us2k10--------
rs1419184301,2
--184244349(+) TTTGTC/TCAGAG 1 -- us2k10--------
rs1150902541,2
F--184244388(+) CTTACG/ACAGAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1463085601,2
--184244565(+) AGGACC/TGGCCT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CLDN24 (184242917 - 184243579 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for CLDN24: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CLDN24
DNA2.0 Custom Variant and Variant Library Synthesis for CLDN24

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
3 diseases for CLDN24:    About MalaCards
teratocarcinoma    endotheliitis    gastric cancer


CLDN24 for disorders           About GeneDecksing


Export disorders for CLDN24 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CLDN24 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLDN24)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
  2. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PubMed id 12736707)1, 3 Katoh M. and Katoh M. (2003)
  3. The claudins. (PubMed id 19706201)1 Lal-Nag M. and Morin P.J. (2009)
  4. Structure and function of claudins. (PubMed id 18036336)1 Krause G....Blasig I.E. (2008)
  5. Tight junction proteins. (PubMed id 12475568)1 Gonzalez-Mariscal L....Jaramillo B.E. (2003)
  6. Claudin-based barrier in simple and stratified cellular sheets. (PubMed id 12231346)1 Tsukita S. and Furuse M. (2002)
  7. The roles of claudin superfamily proteins in paracellular transport. (PubMed id 11247307)1 Heiskala M....Yang Y. (2001)
  8. Multifunctional strands in tight junctions. (PubMed id 11283726)1 Tsukita S....Itoh M. (2001)
  9. Tight junctions of the blood-brain barrier. (PubMed id 10690502)1 Kniesel U. and Wolburg H. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 100132463 HGNC: 37200 Ensembl:ENSG00000185758 euGenes: HUgn100132463 ECgene: CLDN24 Kegg: 100132463
H-InvDB: CLDN24

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CLDN24 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CLDN24 gene:
Search GeneIP for patents involving CLDN24

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for CLDN24
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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