External Ids for CLDN24 Gene
Previous HGNC Symbols for CLDN24 Gene
Previous GeneCards Identifiers for CLDN24 Gene
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is 75% identical to the mouse homolog. This gene is upstream of the CLDN22 gene, which overlaps the WWC2 gene on the opposite strand in the genome.[provided by RefSeq, Aug 2010]
GeneCards Summary for CLDN24 Gene
CLDN24 (Claudin 24) is a Protein Coding gene. Diseases associated with CLDN24 include Mixed Germ Cell Cancer. Among its related pathways are Tight junction and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is CLDN22.
UniProtKB/Swiss-Prot for CLDN24 Gene
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.