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Aliases for CLDN24 Gene

Aliases for CLDN24 Gene

  • Claudin 24 2 3 5
  • Claudin 21 2 3
  • Putative Claudin-24 3
  • CLDN21 3

External Ids for CLDN24 Gene

Previous HGNC Symbols for CLDN24 Gene

  • CLDN21

Previous GeneCards Identifiers for CLDN24 Gene

  • GC04M184480
  • GC04M184242
  • GC04M180003

Summaries for CLDN24 Gene

Entrez Gene Summary for CLDN24 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is 75% identical to the mouse homolog. This gene is upstream of the CLDN22 gene, which overlaps the WWC2 gene on the opposite strand in the genome.[provided by RefSeq, Aug 2010]

GeneCards Summary for CLDN24 Gene

CLDN24 (Claudin 24) is a Protein Coding gene. Diseases associated with CLDN24 include Mixed Germ Cell Cancer. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Cell adhesion molecules (CAMs). GO annotations related to this gene include structural molecule activity. An important paralog of this gene is CLDN22.

UniProtKB/Swiss-Prot for CLDN24 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN24 Gene

Genomics for CLDN24 Gene

Regulatory Elements for CLDN24 Gene

Enhancers for CLDN24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G183347 1.3 Ensembl ENCODE 23.7 -27.1 -27092 4.0 PKNOX1 ATF1 ZNF766 GATA2 ELK1 FOS KLF13 KDM4B CAVIN1 REST CLDN24 CLDN22 LOC100533630
GH04G183397 1.6 FANTOM5 Ensembl ENCODE 10.2 -76.5 -76489 2.2 HDGF PKNOX1 ATF1 ARID4B DMAP1 ZNF2 ZNF48 ZNF766 CBX5 ZNF143 CDKN2AIP CLDN22 CLDN24 LOC100533630 LOC100127981
GH04G183353 0.8 ENCODE 19 -32.6 -32594 2.8 PKNOX1 FEZF1 THRB GATA2 ZNF366 FOS MCM3 MCM5 ZNF398 ZNF843 CLDN24 CLDN22 LOC100533630
GH04G183395 0.8 ENCODE 10.2 -74.0 -74034 1.4 PKNOX1 ATF1 CBX3 NFRKB FOSL1 FOXM1 POLR2A GATA2 EED ETV6 CDKN2AIP CLDN24 CLDN22 LOC100533630 LOC100127981
GH04G183396 0.8 ENCODE 10.2 -73.2 -73167 0.1 PKNOX1 ATF1 CBX3 TBL1XR1 NFRKB TCF12 GATA2 ETV6 CREM ZBTB2 CDKN2AIP CLDN22 CLDN24 LOC100533630 LOC100127981
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLDN24 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLDN24 Gene

183,321,764 bp from pter
183,322,426 bp from pter
663 bases
Minus strand

Genomic View for CLDN24 Gene

Genes around CLDN24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN24 Gene

Proteins for CLDN24 Gene

  • Protein details for CLDN24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative claudin-24
    Protein Accession:
    Secondary Accessions:
    • F5H040

    Protein attributes for CLDN24 Gene

    220 amino acids
    Molecular mass:
    24421 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN24 Gene

Post-translational modifications for CLDN24 Gene

No Post-translational modifications

Other Protein References for CLDN24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN24 Gene

Domains & Families for CLDN24 Gene

Gene Families for CLDN24 Gene

Protein Domains for CLDN24 Gene

Suggested Antigen Peptide Sequences for CLDN24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the claudin family.
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN24: view

Function for CLDN24 Gene

Molecular function for CLDN24 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with CLDN24: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN24 Gene

Localization for CLDN24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN24 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN24 gene
Compartment Confidence
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for CLDN24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CLDN24: view

Pathways & Interactions for CLDN24 Gene

genes like me logo Genes that share pathways with CLDN24: view

Pathways by source for CLDN24 Gene

Interacting Proteins for CLDN24 Gene

Gene Ontology (GO) - Biological Process for CLDN24 Gene


No data available for SIGNOR curated interactions for CLDN24 Gene

Drugs & Compounds for CLDN24 Gene

(1) Drugs for CLDN24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CLDN24: view

Transcripts for CLDN24 Gene

mRNA/cDNA for CLDN24 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN24 Gene

No ASD Table

Relevant External Links for CLDN24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLDN24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLDN24 Gene

NURSA nuclear receptor signaling pathways regulating expression of CLDN24 Gene:


SOURCE GeneReport for Unigene cluster for CLDN24 Gene:

genes like me logo Genes that share expression patterns with CLDN24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN24 Gene

Orthologs for CLDN24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100609738 34
  • 97.73 (n)
CLDN24 35
  • 96 (a)
(Bos Taurus)
Mammalia -- 35
  • 82 (a)
-- 35
  • 75 (a)
(Canis familiaris)
Mammalia CLDN24 34
  • 80 (n)
-- 35
  • 78 (a)
-- 35
  • 70 (a)
(Mus musculus)
Mammalia Cldn24 34 16 35
  • 79.55 (n)
Cldn22 35
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 75 (a)
-- 35
  • 70 (a)
(Gallus gallus)
Aves -- 35
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 68 (a)
(Danio rerio)
Actinopterygii CLDN22 35
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10090 35
  • 30 (a)
-- 35
  • 26 (a)
Species where no ortholog for CLDN24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN24 Gene

Gene Tree for CLDN24 (if available)
Gene Tree for CLDN24 (if available)

Paralogs for CLDN24 Gene

Paralogs for CLDN24 Gene

(18) SIMAP similar genes for CLDN24 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLDN24: view

Variants for CLDN24 Gene

Sequence variations from dbSNP and Humsavar for CLDN24 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000315005 -- 183,323,896(+) TCCAG(A/G)GTGCT upstream-variant-2KB
rs1000759988 -- 183,324,351(+) ACCAG(C/T)CTGAC upstream-variant-2KB
rs1004768762 -- 183,323,564(+) GAGCC(A/C)CTCCC upstream-variant-2KB
rs1006938950 -- 183,323,000(+) TTCCT(C/T)GGATT upstream-variant-2KB
rs1007150398 -- 183,323,271(+) CAGCT(C/T)CCAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLDN24 Gene

Variant ID Type Subtype PubMed ID
nsv1029647 CNV gain 25217958
nsv1030766 CNV gain 25217958

Variation tolerance for CLDN24 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.98; 74.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLDN24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN24 Gene

Disorders for CLDN24 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLDN24 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mixed germ cell cancer
  • mixed germ cell neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CLDN24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CLDN24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN24 Gene

Publications for CLDN24 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  2. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PMID: 12736707) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 3 64
  3. The claudins. (PMID: 19706201) Lal-Nag M. … Morin P.J. (Genome Biol. 2009) 3 64
  4. Structure and function of claudins. (PMID: 18036336) Krause G. … Blasig I.E. (Biochim. Biophys. Acta 2008) 3 64
  5. Tight junction proteins. (PMID: 12475568) GonzA!lez-Mariscal L. … Jaramillo B.E. (Prog. Biophys. Mol. Biol. 2003) 3 64

Products for CLDN24 Gene

Sources for CLDN24 Gene

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