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Aliases for CLDN23 Gene

Aliases for CLDN23 Gene

  • Claudin 23 2 3 5
  • 2310014B08Rik 3
  • Claudin-23 3
  • HCG1646163 3
  • CLDNL 3

External Ids for CLDN23 Gene

Previous GeneCards Identifiers for CLDN23 Gene

  • GC08P008531
  • GC08P008597
  • GC08P007484
  • GC08P008562

Summaries for CLDN23 Gene

Entrez Gene Summary for CLDN23 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010]

GeneCards Summary for CLDN23 Gene

CLDN23 (Claudin 23) is a Protein Coding gene. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include identical protein binding and structural molecule activity.

UniProtKB/Swiss-Prot for CLDN23 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN23 Gene

Genomics for CLDN23 Gene

Regulatory Elements for CLDN23 Gene

Enhancers for CLDN23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G008701 1 ENCODE 40.4 +0.1 82 1.9 ATF1 AGO1 ZFP64 ARID4B SIN3A ZNF48 GLIS2 ELK1 ZNF143 KLF13 CLDN23 FAM66E OR7E154P FAM86B3P FAM90A12P FAM90A11P GC08P008703
GH08G008704 0.6 Ensembl ENCODE 40.7 +2.5 2467 0.4 RBBP5 CLDN23 MFHAS1 GC08P008703 ENSG00000254367
GH08G008712 0.5 ENCODE 40 +11.2 11188 1.2 ATF3 CEBPA HLF CEBPB CEBPG CLDN23 FAM86B3P GC08P008703 ENSG00000254367
GH08G008342 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -355.9 -355904 6.3 PKNOX1 ARNT WRNIP1 CBX5 ZNF207 KLF13 JUNB TBX21 ZNF592 MEF2D FAM86B3P CLDN23 PRAG1 ALG1L13P
GH08G008293 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -406.0 -406006 4.1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 SLC30A9 GLIS2 GATA2 FAM86B3P CLDN23 RPL10P19 ALG1L13P PRAG1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLDN23 on UCSC Golden Path with GeneCards custom track

Promoters for CLDN23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000220787 -137 1600 FOXA2 ATF1 AGO1 ZFP64 ARID4B SIN3A ZNF48 GLIS2 ZNF143 KLF13

Genomic Location for CLDN23 Gene

Chromosome:
8
Start:
8,701,938 bp from pter
End:
8,704,107 bp from pter
Size:
2,170 bases
Orientation:
Plus strand

Genomic View for CLDN23 Gene

Genes around CLDN23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN23 Gene

Proteins for CLDN23 Gene

  • Protein details for CLDN23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B33-CLD23_HUMAN
    Recommended name:
    Claudin-23
    Protein Accession:
    Q96B33
    Secondary Accessions:
    • Q08AJ3

    Protein attributes for CLDN23 Gene

    Size:
    292 amino acids
    Molecular mass:
    31915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN23 Gene

Post-translational modifications for CLDN23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN23 Gene

Domains & Families for CLDN23 Gene

Gene Families for CLDN23 Gene

Protein Domains for CLDN23 Gene

Suggested Antigen Peptide Sequences for CLDN23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96B33

UniProtKB/Swiss-Prot:

CLD23_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN23: view

Function for CLDN23 Gene

Molecular function for CLDN23 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN23: view
genes like me logo Genes that share phenotypes with CLDN23: view

Animal Model Products

miRNA for CLDN23 Gene

miRTarBase miRNAs that target CLDN23

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLDN23 Gene

Localization for CLDN23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN23 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN23 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CLDN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CLDN23: view

Pathways & Interactions for CLDN23 Gene

genes like me logo Genes that share pathways with CLDN23: view

Gene Ontology (GO) - Biological Process for CLDN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
genes like me logo Genes that share ontologies with CLDN23: view

No data available for SIGNOR curated interactions for CLDN23 Gene

Drugs & Compounds for CLDN23 Gene

(1) Drugs for CLDN23 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CLDN23: view

Transcripts for CLDN23 Gene

mRNA/cDNA for CLDN23 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLDN23 Gene

Claudin 23:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN23 Gene

No ASD Table

Relevant External Links for CLDN23 Gene

GeneLoc Exon Structure for
CLDN23
ECgene alternative splicing isoforms for
CLDN23

Expression for CLDN23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLDN23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN23 Gene

This gene is overexpressed in Colon - Transverse (x7.1) and Stomach (x4.5).

Protein differential expression in normal tissues from HIPED for CLDN23 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLDN23 Gene



Protein tissue co-expression partners for CLDN23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLDN23 Gene:

CLDN23

SOURCE GeneReport for Unigene cluster for CLDN23 Gene:

Hs.183617

mRNA Expression by UniProt/SwissProt for CLDN23 Gene:

Q96B33-CLD23_HUMAN
Tissue specificity: Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor.
genes like me logo Genes that share expression patterns with CLDN23: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN23 Gene

Orthologs for CLDN23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLDN23 34 35
  • 98.97 (n)
rat
(Rattus norvegicus)
Mammalia Cldn23 34
  • 81.9 (n)
cow
(Bos Taurus)
Mammalia CLDN23 34 35
  • 81.1 (n)
mouse
(Mus musculus)
Mammalia Cldn23 34 16 35
  • 80.59 (n)
chicken
(Gallus gallus)
Aves CLDN23 34
  • 65.52 (n)
lizard
(Anolis carolinensis)
Reptilia CLDN23 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490599 34
  • 55.11 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC567620 34
  • 52.24 (n)
CLDN23 (1 of 2) 35
  • 30 (a)
OneToMany
CLDN23 (2 of 2) 35
  • 28 (a)
OneToMany
Species where no ortholog for CLDN23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN23 Gene

ENSEMBL:
Gene Tree for CLDN23 (if available)
TreeFam:
Gene Tree for CLDN23 (if available)

Paralogs for CLDN23 Gene

No data available for Paralogs for CLDN23 Gene

Variants for CLDN23 Gene

Sequence variations from dbSNP and Humsavar for CLDN23 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000039358 -- 8,701,764(+) GGACC(A/G)GAAAC upstream-variant-2KB
rs1001756684 -- 8,701,037(+) AGGAG(G/T)TTGCA upstream-variant-2KB
rs1002360727 -- 8,700,190(+) CAATA(C/G)CCAAA upstream-variant-2KB
rs1003170758 -- 8,703,472(+) GTTTT(A/C)CTCTC utr-variant-3-prime
rs1003223177 -- 8,703,723(+) TCAAG(A/G)GGCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CLDN23 Gene

Variant ID Type Subtype PubMed ID
esv2764098 CNV gain+loss 21179565
nsv1022670 CNV loss 25217958

Variation tolerance for CLDN23 Gene

Residual Variation Intolerance Score: 34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.05; 90.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLDN23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLDN23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN23 Gene

Disorders for CLDN23 Gene

Relevant External Links for CLDN23

Genetic Association Database (GAD)
CLDN23
Human Genome Epidemiology (HuGE) Navigator
CLDN23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLDN23

No disorders were found for CLDN23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDN23 Gene

Publications for CLDN23 Gene

  1. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PMID: 12736707) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 3 4 22 64
  2. MRPS18CP2 alleles and DEFA3 absence as putative chromosome 8p23.1 modifiers of hearing loss due to mtDNA mutation A1555G in the 12S rRNA gene. (PMID: 18154640) Ballana E. … Estivill X. (BMC Med. Genet. 2007) 3 46 64
  3. Epithelial-mesenchymal transition in gastric cancer (Review). (PMID: 16273224) Katoh M. (Int. J. Oncol. 2005) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Regulation of the expression of claudin 23 by the enhancer of zeste 2 polycomb group protein in colorectal cancer. (PMID: 25695204) Maryan N. … Ostrowski J. (Mol Med Rep 2015) 3 64

Products for CLDN23 Gene

Sources for CLDN23 Gene

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