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CLDN23 Gene

protein-coding   GIFtS: 50
GCID: GC08P008562

Claudin 23

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Claudin 231 2
2310014B08Rik2
CLDNL2
claudin-232
hCG16461632

External Ids:    HGNC: 175911   Entrez Gene: 1370752   Ensembl: ENSG000002539587   OMIM: 6092035   UniProtKB: Q96B333   

Export aliases for CLDN23 gene to outside databases

Previous GC identifers: GC08P008531 GC08P008597 GC08P007484


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLDN23 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells,
placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer.
(provided by RefSeq, Aug 2010)

GeneCards Summary for CLDN23 Gene:
CLDN23 (claudin 23) is a protein-coding gene. Diseases associated with CLDN23 include endotheliitis, and hepatitis c. GO annotations related to this gene include structural molecule activity and identical protein binding.

UniProtKB/Swiss-Prot: CLD23_HUMAN, Q96B33
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_077531.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLDN23 gene promoter:
         ER-alpha   RFX1   Sp1   Nkx2-5   Roaz   E47   GATA-1   POU2F1   deltaCREB   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN23 promoter sequence
   Search Chromatin IP Primers for CLDN23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

CLDN23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN23 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P008562:  view genomic region     (about GC identifiers)

Start:
8,559,448 bp from pter      End:
8,561,617 bp from pter
Size:
2,170 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CLD23_HUMAN, Q96B33 (See protein sequence)
Recommended Name: Claudin-23  
Size: 292 amino acids; 31915 Da
Secondary accessions: Q08AJ3

Explore the universe of human proteins at neXtProt for CLDN23: NX_Q96B33

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_919260.2  
    ENSEMBL proteins: 
     ENSP00000428780  
    Reactome Protein details: Q96B33

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLDN: Claudins

    3 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry Q96B33

    ProtoNet protein and cluster: Q96B33

    1 Blocks protein domain: IPB006187 Claudin family signature

    UniProtKB/Swiss-Prot: CLD23_HUMAN, Q96B33
    Similarity: Belongs to the claudin family


    CLDN23 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD23_HUMAN, Q96B33
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0042802identical protein binding ISS--
         
    CLDN23 for ontologies           About GeneDecksing


    Animal Models:
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    Block miRNA regulation of human, mouse, rat CLDN23 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CLDN23:
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    SwitchGear 3'UTR luciferase reporter plasmidCLDN23 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLDN23

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLD23_HUMAN, Q96B33: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein
    (By similarity)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral component of membrane IEA--

    CLDN23 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLDN23 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Tight junction
    Tight junction
    5Leukocyte transendothelial migration
    Leukocyte transendothelial migration

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLDN23
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 Reactome Pathway for CLDN23
        Tight junction interactions


    4 Kegg Pathways  (Kegg details for CLDN23):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN23 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLDN23
    Interactions:

        Search GeneGlobe Interaction Network for CLDN23

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--
    GO:0034329cell junction assembly TAS--
    GO:0045216cell-cell junction organization TAS--
    GO:0070830tight junction assembly TAS--

    CLDN23 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLDN23 (CLD23)

    1 HMDB Compound for CLDN23    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLDN23 gene: 
    NM_194284.2  

    Unigene Cluster for CLDN23:

    Claudin 23
    Hs.183617  [show with all ESTs]
    Unigene Representative Sequence: NM_194284
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000519106(uc003wsi.3)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate CLDN23:
    hsa-miR-577 hsa-miR-516b hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidCLDN23 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CLDN23
      QuantiFast Probe-based Assays in human, mouse, rat CLDN23

    Additional mRNA sequence: 

    BC016047.1 BC125148.1 BC125149.1 Z36835.1 

    2 DOTS entries:

    DT.453382  DT.100017972 

    Selected AceView cDNA sequences (see all 32):

    AA226797 AA386169 AI357301 BC016047 AA837489 AA847179 BM821074 BG477807 
    AA836411 BV178511 AA769672 BM821052 BF110053 AA218730 BF224066 BM821022 
    BG992829 BE645458 AW377294 AW375186 AI202492 AW954297 BU590080 AW856093 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLDN23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLDN23 Expression
    About this image


    CLDN23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Renal Collecting Duct System
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Epidermis (Integumentary System)
    CLDN23 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.183617

    UniProtKB/Swiss-Prot: CLD23_HUMAN, Q96B33
    Tissue specificity: Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN23 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn231 , 5 claudin 231, 5 80.59(n)1
    78.77(a)1
      8 (21.21 cM)5
    719081  NM_027998.41  NP_082274.11 
     358247095 
    chicken
    (Gallus gallus)
    Aves CLDN231 claudin 23 65.52(n)
    59.91(a)
      428756  XM_004941160.1  XP_004941217.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLDN236
    claudin 23
    53(a)
    1 ↔ 1
    GL343257.1(976194-976595)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004905991 claudin-23-like 55.11(n)
    49.64(a)
      100490599  XM_004911061.1  XP_004911118.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5676201 claudin-23-like 52.24(n)
    41.13(a)
      567620  XM_005155580.1  XP_005155637.1 


    ENSEMBL Gene Tree for CLDN23 (if available)
    TreeFam Gene Tree for CLDN23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLDN23 (see all 171)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101054131,2
    C,F--7482573(+) ttaaaA/GGTGAT 1 -- us2k12Minor allele frequency- G:0.12WA 120
    rs96447721,2
    C,F,A,H--8557685(+) CaacaG/Acatta 1 -- us2k17Minor allele frequency- A:0.25NA WA EA 366
    rs1873557631,2
    --8557726(+) AAGTGC/TCTATG 1 -- us2k10--------
    rs17039841,2
    C,H--8557768(+) ttatgT/Cacaat 1 -- us2k113Minor allele frequency- C:0.00NA WA CSA EA 378
    rs360959891,2
    C,F--8557862(+) AAATAA/TGCCAG 1 -- us2k16Minor allele frequency- T:0.34NA WA 246
    rs1922552251,2
    --8557864(+) ATAAGC/TCAGTC 1 -- us2k10--------
    rs1159781381,2
    F--8557979(+) AGGGAG/AGAAAG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs607483821,2
    C,F--8557986(+) AAAGGA/GGAGTT 1 -- us2k13Minor allele frequency- G:0.15WA CSA 121
    rs96447731,2
    C,F,A,H--8558080(+) atgtaT/Cgtcat 1 -- us2k111Minor allele frequency- C:0.35NA WA CSA EA 377
    rs1486150821,2
    --8558120(+) ACAACA/GGTCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLDN23 (8559448 - 8561617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CLDN23:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv890331CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CLDN23
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609203    OMIM disorders: --

    6 diseases for CLDN23:    
    About MalaCards
    endotheliitis    hepatitis c    pancreatic cancer    pancreatitis
    hepatitis    obesity


    CLDN23 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLDN23
    Human Genome Epidemiology (HuGE) Navigator: CLDN23 (1 document)

    Export disorders for CLDN23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLDN23 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CLDN23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PubMed id 12736707)1, 2, 3, 9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2003)
    2. MRPS18CP2 alleles and DEFA3 absence as putative chromosome 8p23.1 modifiers of hearing loss due to mtDNA mutation A1555G in the 12S rRNA gene. (PubMed id 18154640)1, 4 Ballana E....Estivill X. (BMC Med. Genet. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Epithelial-mesenchymal transition in gastric cancer (Review). (PubMed id 16273224)1, 9 Katoh M. (Int. J. Oncol. 2005)
    5. Differential expression and prognostic role of selected genes in colorectal cancer patients. (PubMed id 24222123)1 Pitule P....Liska V. (Anticancer Res. 2013)
    6. A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1. (PubMed id 24189493)1 Chen H.W....Tan B.C. (Biochim. Biophys. Acta 2013)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. The claudins. (PubMed id 19706201)1 Lal-Nag M. and Morin P.J. (Genome Biol. 2009)
    9. Ion transport and barrier function in a telomerase-immortalized human nondysplastic, Barrett's cell line (BAR-T). (PubMed id 19673046)1 Jovov B....Orlando R.C. (Dis. Esophagus 2009)
    10. Structure and function of claudins. (PubMed id 18036336)1 Krause G....Blasig I.E. (Biochim. Biophys. Acta 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 137075 HGNC: 17591 AceView: CLDN23 Ensembl:ENSG00000253958 euGenes: HUgn137075
    ECgene: CLDN23 Kegg: 137075 H-InvDB: CLDN23

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CLDN23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLDN23 gene:
    Search GeneIP for patents involving CLDN23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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