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Aliases for CLDN23 Gene

Aliases for CLDN23 Gene

  • Claudin 23 2 3
  • 2310014B08Rik 3
  • HCG1646163 3
  • CLDNL 3

External Ids for CLDN23 Gene

Previous GeneCards Identifiers for CLDN23 Gene

  • GC08P008531
  • GC08P008597
  • GC08P007484
  • GC08P008562

Summaries for CLDN23 Gene

Entrez Gene Summary for CLDN23 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010]

GeneCards Summary for CLDN23 Gene

CLDN23 (Claudin 23) is a Protein Coding gene. Among its related pathways are Integrin Pathway and Cell junction organization. GO annotations related to this gene include identical protein binding and structural molecule activity.

UniProtKB/Swiss-Prot for CLDN23 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN23 Gene

Genomics for CLDN23 Gene

Regulatory Elements for CLDN23 Gene

Genomic Location for CLDN23 Gene

Chromosome:
8
Start:
8,701,938 bp from pter
End:
8,704,107 bp from pter
Size:
2,170 bases
Orientation:
Plus strand

Genomic View for CLDN23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLDN23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN23 Gene

Proteins for CLDN23 Gene

  • Protein details for CLDN23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B33-CLD23_HUMAN
    Recommended name:
    Claudin-23
    Protein Accession:
    Q96B33
    Secondary Accessions:
    • Q08AJ3

    Protein attributes for CLDN23 Gene

    Size:
    292 amino acids
    Molecular mass:
    31915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN23 Gene

Proteomics data for CLDN23 Gene at MOPED

Post-translational modifications for CLDN23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN23 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CLDN23 Gene

Domains & Families for CLDN23 Gene

Gene Families for CLDN23 Gene

Protein Domains for CLDN23 Gene

Suggested Antigen Peptide Sequences for CLDN23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96B33

UniProtKB/Swiss-Prot:

CLD23_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN23: view

Function for CLDN23 Gene

Molecular function for CLDN23 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN23: view
genes like me logo Genes that share phenotypes with CLDN23: view

Animal Model Products

miRNA for CLDN23 Gene

miRTarBase miRNAs that target CLDN23

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN23

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CLDN23 Gene

Localization for CLDN23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN23 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDN23 Gene COMPARTMENTS Subcellular localization image for CLDN23 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CLDN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLDN23: view

Pathways & Interactions for CLDN23 Gene

genes like me logo Genes that share pathways with CLDN23: view

Interacting Proteins for CLDN23 Gene

Gene Ontology (GO) - Biological Process for CLDN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
GO:0034329 cell junction assembly TAS --
GO:0045216 cell-cell junction organization TAS --
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with CLDN23: view

No data available for SIGNOR curated interactions for CLDN23 Gene

Drugs & Compounds for CLDN23 Gene

(1) Drugs for CLDN23 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with CLDN23: view

Transcripts for CLDN23 Gene

mRNA/cDNA for CLDN23 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLDN23 Gene

Claudin 23:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN23

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN23 Gene

No ASD Table

Relevant External Links for CLDN23 Gene

GeneLoc Exon Structure for
CLDN23
ECgene alternative splicing isoforms for
CLDN23

Expression for CLDN23 Gene

mRNA expression in normal human tissues for CLDN23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN23 Gene

This gene is overexpressed in Colon - Transverse (x7.1) and Stomach (x4.5).

Protein differential expression in normal tissues from HIPED for CLDN23 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLDN23 Gene



SOURCE GeneReport for Unigene cluster for CLDN23 Gene Hs.183617

mRNA Expression by UniProt/SwissProt for CLDN23 Gene

Q96B33-CLD23_HUMAN
Tissue specificity: Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor.
genes like me logo Genes that share expression patterns with CLDN23: view

Protein tissue co-expression partners for CLDN23 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CLDN23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLDN23 35
  • 81.1 (n)
  • 75.95 (a)
CLDN23 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cldn23 35
  • 80.59 (n)
  • 78.77 (a)
Cldn23 16
Cldn23 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLDN23 35
  • 98.97 (n)
  • 97.93 (a)
CLDN23 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldn23 35
  • 81.9 (n)
  • 80.41 (a)
chicken
(Gallus gallus)
Aves CLDN23 35
  • 65.52 (n)
  • 59.91 (a)
lizard
(Anolis carolinensis)
Reptilia CLDN23 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490599 35
  • 55.11 (n)
  • 49.64 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC567620 35
  • 52.24 (n)
  • 41.13 (a)
CLDN23 (1 of 2) 36
  • 30 (a)
OneToMany
CLDN23 (2 of 2) 36
  • 28 (a)
OneToMany
Species with no ortholog for CLDN23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN23 Gene

ENSEMBL:
Gene Tree for CLDN23 (if available)
TreeFam:
Gene Tree for CLDN23 (if available)

Paralogs for CLDN23 Gene

No data available for Paralogs for CLDN23 Gene

Variants for CLDN23 Gene

Sequence variations from dbSNP and Humsavar for CLDN23 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs12058 -- 8,703,571(+) TGGAC(A/C)AGGGA utr-variant-3-prime
rs12153 -- 8,703,399(-) TCCCA(C/G)GAAAG utr-variant-3-prime
rs1060106 -- 8,703,942(-) ACCTT(C/T)GTTCT utr-variant-3-prime
rs1060107 -- 8,703,889(-) TTCAC(A/C/T)GCAAA utr-variant-3-prime
rs1703984 -- 8,700,258(+) ttatg(C/T)acaat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLDN23 Gene

Variant ID Type Subtype PubMed ID
nsv890331 CNV Loss 21882294

Variation tolerance for CLDN23 Gene

Residual Variation Intolerance Score: 34.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.05; 90.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLDN23 Gene

HapMap Linkage Disequilibrium report
CLDN23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN23 Gene

Disorders for CLDN23 Gene

Relevant External Links for CLDN23

Genetic Association Database (GAD)
CLDN23
Human Genome Epidemiology (HuGE) Navigator
CLDN23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLDN23
genes like me logo Genes that share disorders with CLDN23: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDN23 Gene

Publications for CLDN23 Gene

  1. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PMID: 12736707) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 23 67
  2. Epithelial-mesenchymal transition in gastric cancer (Review). (PMID: 16273224) Katoh M. (Int. J. Oncol. 2005) 23 67
  3. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. (PMID: 24483146) Li L. … Wang L. (BMC Genomics 2014) 67
  4. Differential expression and prognostic role of selected genes in colorectal cancer patients. (PMID: 24222123) Pitule P. … Liska V. (Anticancer Res. 2013) 67
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 67

Products for CLDN23 Gene

Sources for CLDN23 Gene

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