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Aliases for CLDN23 Gene

Aliases for CLDN23 Gene

  • Claudin 23 2 3 5
  • 2310014B08Rik 3
  • Claudin-23 3
  • HCG1646163 3
  • CLDNL 3

External Ids for CLDN23 Gene

Previous GeneCards Identifiers for CLDN23 Gene

  • GC08P008531
  • GC08P008597
  • GC08P007484
  • GC08P008562

Summaries for CLDN23 Gene

Entrez Gene Summary for CLDN23 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010]

GeneCards Summary for CLDN23 Gene

CLDN23 (Claudin 23) is a Protein Coding gene. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Blood-Brain Barrier Pathway: Anatomy. Gene Ontology (GO) annotations related to this gene include identical protein binding and structural molecule activity.

UniProtKB/Swiss-Prot for CLDN23 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Additional gene information for CLDN23 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN23 Gene

Genomics for CLDN23 Gene

GeneHancer (GH) Regulatory Elements for CLDN23 Gene

Promoters and enhancers for CLDN23 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I008701 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 590.4 +0.0 36 1.9 ATF1 ZFP64 ARID4B SIN3A ZNF48 GLIS2 ZNF213 ELK1 ZNF143 ATF7 CLDN23 GC08P008703 FAM86B3P OR7E154P FAM66E FAM90A12P
GH08I008712 Enhancer 0.5 ENCODE 40.1 +11.2 11188 1.2 HLF CEBPA CEBPB CEBPG CLDN23 FAM86B3P ENSG00000284717 GC08P008703
GH08I008342 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -355.9 -355904 6.3 PKNOX1 ATF1 ARNT IRF4 NCOA2 TCF12 GATA2 E2F8 ZNF207 ATF7 FAM86B3P CLDN23 PRAG1 ALG1L13P
GH08I008293 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -406.0 -406005 4.1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 ETS1 SLC30A9 GLIS2 FAM86B3P CLDN23 RPL10P19 ALG1L13P PRAG1
GH08I008704 Enhancer 0.4 Ensembl ENCODE 40.8 +2.5 2467 0.4 GC08P008703 CLDN23 MFHAS1 ENSG00000284717
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLDN23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLDN23 gene promoter:

Genomic Locations for CLDN23 Gene

Genomic Locations for CLDN23 Gene
2,170 bases
Plus strand

Genomic View for CLDN23 Gene

Genes around CLDN23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN23 Gene

Proteins for CLDN23 Gene

  • Protein details for CLDN23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q08AJ3

    Protein attributes for CLDN23 Gene

    292 amino acids
    Molecular mass:
    31915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN23 Gene

Post-translational modifications for CLDN23 Gene

No Post-translational modifications

Other Protein References for CLDN23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN23 Gene

Domains & Families for CLDN23 Gene

Gene Families for CLDN23 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for CLDN23 Gene

Suggested Antigen Peptide Sequences for CLDN23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the claudin family.
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN23: view

Function for CLDN23 Gene

Molecular function for CLDN23 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Phenotypes From GWAS Catalog for CLDN23 Gene

Gene Ontology (GO) - Molecular Function for CLDN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN23: view
genes like me logo Genes that share phenotypes with CLDN23: view

miRNA for CLDN23 Gene

miRTarBase miRNAs that target CLDN23

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLDN23 Gene

Localization for CLDN23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN23 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN23 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CLDN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CLDN23: view

Pathways & Interactions for CLDN23 Gene

genes like me logo Genes that share pathways with CLDN23: view

Gene Ontology (GO) - Biological Process for CLDN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
genes like me logo Genes that share ontologies with CLDN23: view

No data available for SIGNOR curated interactions for CLDN23 Gene

Drugs & Compounds for CLDN23 Gene

(1) Drugs for CLDN23 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CLDN23: view

Transcripts for CLDN23 Gene

mRNA/cDNA for CLDN23 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLDN23 Gene

Claudin 23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN23 Gene

No ASD Table

Relevant External Links for CLDN23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLDN23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLDN23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN23 Gene

This gene is overexpressed in Colon - Transverse (x7.1) and Stomach (x4.5).

Protein differential expression in normal tissues from HIPED for CLDN23 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLDN23 Gene

Protein tissue co-expression partners for CLDN23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLDN23 Gene:


SOURCE GeneReport for Unigene cluster for CLDN23 Gene:


mRNA Expression by UniProt/SwissProt for CLDN23 Gene:

Tissue specificity: Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor.
genes like me logo Genes that share expression patterns with CLDN23: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN23 Gene

Orthologs for CLDN23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLDN23 33 34
  • 98.97 (n)
(Rattus norvegicus)
Mammalia Cldn23 33
  • 81.9 (n)
(Bos Taurus)
Mammalia CLDN23 33 34
  • 81.1 (n)
(Mus musculus)
Mammalia Cldn23 33 16 34
  • 80.59 (n)
(Gallus gallus)
Aves CLDN23 33
  • 65.52 (n)
(Anolis carolinensis)
Reptilia CLDN23 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490599 33
  • 55.11 (n)
(Danio rerio)
Actinopterygii LOC567620 33
  • 52.24 (n)
CLDN23 (1 of 2) 34
  • 30 (a)
CLDN23 (2 of 2) 34
  • 28 (a)
Species where no ortholog for CLDN23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN23 Gene

Gene Tree for CLDN23 (if available)
Gene Tree for CLDN23 (if available)

Paralogs for CLDN23 Gene

No data available for Paralogs for CLDN23 Gene

Variants for CLDN23 Gene

Sequence variations from dbSNP and Humsavar for CLDN23 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000039358 -- 8,701,764(+) G/A upstream_transcript_variant
rs1001756684 -- 8,701,037(+) T/G upstream_transcript_variant
rs1002360727 -- 8,700,190(+) G/C upstream_transcript_variant
rs1003170758 -- 8,703,472(+) C/A 3_prime_UTR_variant
rs1003223177 -- 8,703,723(+) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CLDN23 Gene

Variant ID Type Subtype PubMed ID
esv2764098 CNV gain+loss 21179565
nsv1022670 CNV loss 25217958

Variation tolerance for CLDN23 Gene

Residual Variation Intolerance Score: 34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.05; 90.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLDN23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN23 Gene

Disorders for CLDN23 Gene

Additional Disease Information for CLDN23

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CLDN23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDN23 Gene

Publications for CLDN23 Gene

  1. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PMID: 12736707) Katoh M … Katoh M (International journal of molecular medicine 2003) 2 3 4 22 58
  2. MRPS18CP2 alleles and DEFA3 absence as putative chromosome 8p23.1 modifiers of hearing loss due to mtDNA mutation A1555G in the 12S rRNA gene. (PMID: 18154640) Ballana E … Estivill X (BMC medical genetics 2007) 3 44 58
  3. Epithelial-mesenchymal transition in gastric cancer (Review). (PMID: 16273224) Katoh M (International journal of oncology 2005) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Expression of claudin-11, -23 in different gastric tissues and its relationship with the risk and prognosis of gastric cancer. (PMID: 28350854) Lu Y … Yuan Y (PloS one 2017) 3 58

Products for CLDN23 Gene

Sources for CLDN23 Gene

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