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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CLDN23 Gene

protein-coding GIFtS: 49
GCID: GC08P008562

claudin 23

Explore 6 diseases affiliated with
CLDN23 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Claudin 23¹ ²
CLDNL¹ ²
2310014B08Rik²
Claudin-23¹
HCG1646163¹

External Ids:	HGNC: 17591¹	Entrez Gene: 137075²	Ensembl: ENSG00000253958⁷	OMIM: 609203⁵	UniProtKB: Q96B33³

Export aliases for CLDN23 gene to outside databases

Previous GC identifers: GC08P008531 GC08P008597 GC08P007484

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLDN23:

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight

junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely

through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in

maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and

stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. (provided by RefSeq,

Aug 2010)

UniProtKB/Swiss-Prot: CLD23_HUMAN, Q96B33

Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through

calcium-independent cell-adhesion activity (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_077531.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CLDN23 gene promoter:
ER-alpha RFX1 Sp1 Nkx2-5 Roaz E47 GATA-1 POU2F1 deltaCREB POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLDN23 promoter sequence

Search SABiosciences Chromatin IP Primers for CLDN23

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN23

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1

CLDN23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN23 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P008562: view genomic region (about GC identifiers)

Start:	8,559,448 bp from pter	End:	8,561,617 bp from pter
Size:	2,170 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLD23_HUMAN, Q96B33 (See protein sequence)

Recommended Name: Claudin-23

Size: 292 amino acids; 31915 Da

Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By

similarity)

Secondary accessions: Q08AJ3

Explore the universe of human proteins at neXtProt for CLDN23: NX_Q96B33

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96B33

CLDN23 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_919260.2

ENSEMBL proteins:

ENSP00000428780

Reactome Protein details: Q96B33
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	Uscn Proteins for CLDN23

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005923	tight junction	ISS	--
GO:0016021	integral to membrane	IEA	--

CLDN23 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CLDN23

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CLDN23 for domains About GeneDecksing

3 InterPro domains/families:

IPR017974 Claudin_CS

IPR006187 Claudin

IPR004031 PMP22/EMP/MP20/Claudin

Graphical View of Domain Structure for InterPro Entry Q96B33

ProtoNet protein and cluster: Q96B33

1 Blocks protein family: IPB006187 Claudin family signature

UniProtKB/Swiss-Prot: CLD23_HUMAN, Q96B33

Similarity: Belongs to the claudin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CLD23_HUMAN, Q96B33

Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through

calcium-independent cell-adhesion activity (By similarity)

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		hsa-miR-577 hsa-miR-516b hsa-miR-340
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN23

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--
GO:0042802	identical protein binding	ISS	--

CLDN23 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell-cell junction organization

	Cell-cell junction organization	1.00			Tight junction interactions	0.49
	Cell junction organization	0.69			Cell-Cell communication	0.45

Sertoli-Sertoli Cell Junction Dynamics

Sertoli-Sertoli Cell Junction Dynamics

1.00

Epithelial Tight Junctions

0.36

Hepatitis C

Hepatitis C

1.00

Leukocyte transendothelial migration

Leukocyte transendothelial migration

1.00

Tight junction

Tight junction

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN23

	Sertoli-Sertoli Cell Junction Dynamics
	Epithelial Tight Junctions
	Transendothelial Migration of Leukocytes

4 Reactome Pathways for CLDN23

	Tight junction interactions
	Cell junction organization
	Cell-Cell communication
	Cell-cell junction organization

4 Kegg Pathways (Kegg details for CLDN23):

	Cell adhesion molecules (CAMs)
	Tight junction
	Leukocyte transendothelial migration
	Hepatitis C

CLDN23 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CLDN23

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016338	calcium-independent cell-cell adhesion	ISS	--
GO:0034329	cell junction assembly	TAS	--
GO:0045216	cell-cell junction organization	TAS	--
GO:0070830	tight junction assembly	TAS	--

CLDN23 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLDN23

1 HMDB Compound for CLDN23 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about CLDN23 / CLD23

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLDN23 gene:

NM_194284.2

Unigene Cluster for CLDN23:

Claudin 23

Hs.183617 [show with all ESTs]

Unigene Representative Sequence: NM_194284

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000519106(uc003wsi.3)

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		hsa-miR-577 hsa-miR-516b hsa-miR-340
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Additional cDNA sequence:

BC016047.1 BC125148.1 BC125149.1 Z36835.1

2 DOTS entries:

DT.453382 DT.100017972

24/32 AceView cDNA sequences (see all 32):

AA386169 AI357301 AA226797 AA769672 AA218730 AA847179 BC016047 BF224066

AA836411 BF110053 BM821052 AA837489 BV178511 BM821074 BG477807 AI202492

BG992829 BM821022 AW954297 AW377294 BE645458 AW375186 BU590080 AW856093

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLDN23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CLDN23 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Collecting Duct System

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Genevestigator expression for CLDN23

SOURCE GeneReport for Unigene cluster: Hs.183617

UniProtKB/Swiss-Prot: CLD23_HUMAN, Q96B33

Tissue specificity: Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CLDN23 gene from 4/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cldn23^{1 , 5}	claudin 23^{1, 5}	80.14(n)¹ 78.77(a)¹		8 (21.21 cM)⁵ 71908¹ NM_027998.4¹ NP_082274.1¹ 35824709⁵
chicken (Gallus gallus)	Aves	CLDN23¹	claudin 23	64.8(n) 59.48(a)		428756 XM_426312.1 XP_426312.1
lizard (Anolis carolinensis)	Reptilia	CLDN23⁶	--	54(a)	1 ↔ 1	GL343257.1(976194-976595)
zebrafish (Danio rerio)	Actinopterygii	LOC567620¹	claudin-23-like	52.38(n) 41.13(a)		567620 XM_690921.3 XP_696013.2

ENSEMBL Gene Tree for CLDN23 (if available)
TreeFam Gene Tree for CLDN23 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9644772^1,2	C,F,A,H,	--	8557685(+)	`CAACAG/ACATTA`	1	--	us2k¹		7		NA WA EA	366
rs187355763^1,2		--	8557726(+)	`AAGTGC/TCTATG`	1	--	us2k¹		0	--	--	--	--
rs1703984^1,2	C,H,	--	8557768(+)	`TTATGT/CACAAT`	1	--	us2k¹		13		NA WA CSA EA	378
rs36095989^1,2	C,F,	--	8557862(+)	`AAATAA/TGCCAG`	1	--	us2k¹		6		NA WA	246
rs192255225^1,2		--	8557864(+)	`ATAAGC/TCAGTC`	1	--	us2k¹		0	--	--	--	--
rs115978138^1,2		--	8557979(+)	`AGGGAG/AGAAAG`	1	--	us2k¹		1		WA	118
rs60748382^1,2	C,	--	8557986(+)	`AAAGGA/GGAGTT`	1	--	us2k¹		3		WA CSA	121
rs9644773^1,2	C,F,A,H,	--	8558080(+)	`ATGTAT/CGTCAT`	1	--	us2k¹		11		NA WA CSA EA	377
rs148615082^1,2		--	8558120(+)	`ACAACA/GGTCAA`	1	--	us2k¹		0	--	--	--	--
rs147605190^1,2	C,	--	8558153(+)	`ACAGG-/TTTTTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CLDN23 (8559448 - 8561617 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for CLDN23
15/16 Inversions (see all 16): 37318 37316 37307 37317 37311 37319 37320 37315 37312 37321 37304 37313 37314 37305 37306

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CLDN23 for disorders           About GeneDecksing

OMIM gene information: 609203    OMIM disorders: --

6 diseases for CLDN23:    About MalaCards

gastric cancer hearing loss hepatitis c pancreatic cancer

pancreatitis hepatitis

Human Genome Epidemiology (HuGE) Navigator: CLDN23 (1 document)

Export disorders for CLDN23 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CLDN23 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLDN23)

Utopia: connect your pdf to the dynamic
world of online information

CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PubMed id 12736707)^{1, 2, 3, 9} Katoh M. and Katoh M. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Epithelial-mesenchymal transition in gastric cancer (Review). (PubMed id 16273224)^{1, 9} Katoh M. (2005)
The claudins. (PubMed id 19706201)¹ Lal-Nag M. and Morin P.J. (2009)
Ion transport and barrier function in a telomerase-im mortalized human nondysplastic, Barrett's cell line (BAR-T). (PubMed id 19673046)¹ Jovov B....Orlando R.C. (2009)
Structure and function of claudins. (PubMed id 18036336)¹ Krause G....Blasig I.E. (2008)
MRPS18CP2 alleles and DEFA3 absence as putative chromosome 8p23.1 modifiers of hearing loss due to mtDNA mutation A1555G in the 12S rRNA gene. (PubMed id 18154640)¹ Ballana E....Estivill X. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
The sequence of the human genome. (PubMed id 11181995)¹ Venter J.C.... Zhu X. (2001)
A pancreatic cancer-specific expression profile. (PubMed id 8895530)¹ Gress T.M....Lehrach H. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 137075	HGNC: 17591	AceView: CLDN23	Ensembl:ENSG00000253958	euGenes: HUgn137075
ECgene: CLDN23	Kegg: 137075	H-InvDB: CLDN23

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CLDN23	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CLDN23 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CLDN23 gene:
Search GeneIP for patents involving CLDN23

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLDN23
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CLDN23 gene at Home site.

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CLDN23 Gene

claudin 23

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CLDN23 Gene

claudin 23

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