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Aliases for CLDN22 Gene

Aliases for CLDN22 Gene

  • Claudin 22 2 3
  • Claudin-22 3
  • CLDN21 3

External Ids for CLDN22 Gene

Previous GeneCards Identifiers for CLDN22 Gene

  • GC04U990095
  • GC04M184937
  • GC04M184615
  • GC04M184477
  • GC04M184239
  • GC04M179999

Summaries for CLDN22 Gene

Entrez Gene Summary for CLDN22 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. [provided by RefSeq, Aug 2010]

GeneCards Summary for CLDN22 Gene

CLDN22 (Claudin 22) is a Protein Coding gene. Among its related pathways are Cell junction organization and Cell junction organization. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN15.

UniProtKB/Swiss-Prot for CLDN22 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Wiki entry for CLDN22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN22 Gene

Genomics for CLDN22 Gene

Regulatory Elements for CLDN22 Gene

Genomic Location for CLDN22 Gene

183,318,067 bp from pter
183,320,774 bp from pter
2,708 bases
Minus strand

Genomic View for CLDN22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLDN22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN22 Gene

Proteins for CLDN22 Gene

  • Protein details for CLDN22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CLDN22 Gene

    220 amino acids
    Molecular mass:
    24509 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN22 Gene

Proteomics data for CLDN22 Gene at MOPED

Post-translational modifications for CLDN22 Gene

No Post-translational modifications

Other Protein References for CLDN22 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN22 Gene

Domains for CLDN22 Gene

Gene Families for CLDN22 Gene


Protein Domains for CLDN22 Gene

Suggested Antigen Peptide Sequences for CLDN22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8N7P3
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN22: view

Function for CLDN22 Gene

Molecular function for CLDN22 Gene

UniProtKB/Swiss-Prot Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN22: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLDN22 Gene

Localization for CLDN22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN22 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CLDN22 Gene COMPARTMENTS Subcellular localization image for CLDN22 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CLDN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLDN22: view

Pathways for CLDN22 Gene

genes like me logo Genes that share pathways with CLDN22: view

Interacting Proteins for CLDN22 Gene

Gene Ontology (GO) - Biological Process for CLDN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
GO:0034329 cell junction assembly TAS --
GO:0045216 cell-cell junction organization TAS --
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with CLDN22: view

Compounds for CLDN22 Gene

(1) HMDB Compounds for CLDN22 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with CLDN22: view

Transcripts for CLDN22 Gene

mRNA/cDNA for CLDN22 Gene

(120) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN22 Gene

No ASD Table

Relevant External Links for CLDN22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLDN22 Gene

mRNA expression in normal human tissues for CLDN22 Gene

genes like me logo Genes that share expressions with CLDN22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for CLDN22 Gene

Orthologs for CLDN22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLDN22 35
  • 98.64 (n)
  • 97.73 (a)
CLDN22 36
  • 98 (a)
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
-- 36
  • 76 (a)
CLDN22 35
  • 84.47 (n)
  • 82.65 (a)
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
-- 36
  • 78 (a)
CLDN22 35
  • 78.23 (n)
  • 78.54 (a)
(Mus musculus)
Mammalia Cldn22 35
  • 78.96 (n)
  • 76.5 (a)
Cldn22 16
Cldn22 36
  • 75 (a)
Cldn24 36
  • 73 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
-- 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Cldn22 35
  • 79.26 (n)
  • 77.88 (a)
(Gallus gallus)
Aves -- 36
  • 72 (a)
LOC100858888 35
  • 73.33 (n)
  • 72.56 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cldn22 35
  • 65.58 (n)
  • 61.86 (a)
(Danio rerio)
Actinopterygii CLDN22 36
  • 43 (a)
si:dkey-98f17.3 35
  • 54.59 (n)
  • 44.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
-- 36
  • 20 (a)
-- 36
  • 26 (a)
-- 36
  • 22 (a)
CSA.10090 36
  • 29 (a)
Species with no ortholog for CLDN22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN22 Gene

Gene Tree for CLDN22 (if available)
Gene Tree for CLDN22 (if available)

Paralogs for CLDN22 Gene

Paralogs for CLDN22 Gene

Selected SIMAP similar genes for CLDN22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLDN22: view

Variants for CLDN22 Gene

Relevant External Links for CLDN22 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for CLDN22 Gene

Disorders for CLDN22 Gene

No disorders were found for CLDN22 Gene.

No data available for UniProtKB/Swiss-Prot for CLDN22 Gene

Publications for CLDN22 Gene

  1. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PMID: 12736707) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 3 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Structure and function of claudins. (PMID: 18036336) Krause G. … Blasig I.E. (Biochim. Biophys. Acta 2008) 3
  5. The claudins. (PMID: 19706201) Lal-Nag M. … Morin P.J. (Genome Biol. 2009) 3

Products for CLDN22 Gene

Sources for CLDN22 Gene

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