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Aliases for CLDN22 Gene

Aliases for CLDN22 Gene

  • Claudin 22 2 3 5
  • CLDN21 3

External Ids for CLDN22 Gene

Previous GeneCards Identifiers for CLDN22 Gene

  • GC04U990095
  • GC04M184937
  • GC04M184615
  • GC04M184477
  • GC04M184239
  • GC04M179999

Summaries for CLDN22 Gene

Entrez Gene Summary for CLDN22 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. [provided by RefSeq, Aug 2010]

GeneCards Summary for CLDN22 Gene

CLDN22 (Claudin 22) is a Protein Coding gene. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN18.

UniProtKB/Swiss-Prot for CLDN22 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Wiki entry for CLDN22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN22 Gene

Genomics for CLDN22 Gene

Regulatory Elements for CLDN22 Gene

Genomic Location for CLDN22 Gene

183,318,067 bp from pter
183,320,774 bp from pter
2,708 bases
Minus strand

Genomic View for CLDN22 Gene

Genes around CLDN22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN22 Gene

Proteins for CLDN22 Gene

  • Protein details for CLDN22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for CLDN22 Gene

    220 amino acids
    Molecular mass:
    24509 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN22 Gene

Proteomics data for CLDN22 Gene at MOPED

Post-translational modifications for CLDN22 Gene

No Post-translational modifications

Other Protein References for CLDN22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN22 Gene

Domains & Families for CLDN22 Gene

Gene Families for CLDN22 Gene

Protein Domains for CLDN22 Gene

Suggested Antigen Peptide Sequences for CLDN22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the claudin family.
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN22: view

Function for CLDN22 Gene

Molecular function for CLDN22 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Phenotypes for CLDN22 Gene

GenomeRNAi human phenotypes for CLDN22:
genes like me logo Genes that share phenotypes with CLDN22: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN22 Gene

Localization for CLDN22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN22 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CLDN22 Gene COMPARTMENTS Subcellular localization image for CLDN22 gene
Compartment Confidence
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for CLDN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CLDN22: view

Pathways & Interactions for CLDN22 Gene

genes like me logo Genes that share pathways with CLDN22: view

Interacting Proteins for CLDN22 Gene

Gene Ontology (GO) - Biological Process for CLDN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034329 cell junction assembly TAS --
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with CLDN22: view

No data available for SIGNOR curated interactions for CLDN22 Gene

Drugs & Compounds for CLDN22 Gene

(1) Drugs for CLDN22 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CLDN22: view

Transcripts for CLDN22 Gene

mRNA/cDNA for CLDN22 Gene

(1) REFSEQ mRNAs :
(120) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN22 Gene

No ASD Table

Relevant External Links for CLDN22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLDN22 Gene

mRNA expression in normal human tissues for CLDN22 Gene

genes like me logo Genes that share expression patterns with CLDN22: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CLDN22 Gene

Orthologs for CLDN22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLDN22 35
  • 84.47 (n)
  • 82.65 (a)
-- 36
  • 82 (a)
-- 36
  • 76 (a)
(Canis familiaris)
Mammalia CLDN22 35
  • 78.23 (n)
  • 78.54 (a)
-- 36
  • 73 (a)
-- 36
  • 78 (a)
(Mus musculus)
Mammalia Cldn22 35
  • 78.96 (n)
  • 76.5 (a)
Cldn22 16
Cldn22 36
  • 75 (a)
Cldn24 36
  • 73 (a)
(Pan troglodytes)
Mammalia CLDN22 35
  • 98.64 (n)
  • 97.73 (a)
CLDN22 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Cldn22 35
  • 79.26 (n)
  • 77.88 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
-- 36
  • 73 (a)
(Gallus gallus)
Aves LOC100858888 35
  • 73.33 (n)
  • 72.56 (a)
-- 36
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cldn22 35
  • 65.58 (n)
  • 61.86 (a)
(Danio rerio)
Actinopterygii si:dkey-98f17.3 35
  • 54.59 (n)
  • 44.04 (a)
CLDN22 36
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
-- 36
  • 20 (a)
-- 36
  • 26 (a)
-- 36
  • 22 (a)
CSA.10090 36
  • 29 (a)
Species with no ortholog for CLDN22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN22 Gene

Gene Tree for CLDN22 (if available)
Gene Tree for CLDN22 (if available)

Paralogs for CLDN22 Gene

Paralogs for CLDN22 Gene

(18) SIMAP similar genes for CLDN22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLDN22: view

Variants for CLDN22 Gene

Variation tolerance for CLDN22 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLDN22 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for CLDN22 Gene

Disorders for CLDN22 Gene

Relevant External Links for CLDN22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLDN22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDN22 Gene

Publications for CLDN22 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PMID: 12736707) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 3 23
  3. The claudins. (PMID: 19706201) Lal-Nag M. … Morin P.J. (Genome Biol. 2009) 3
  4. Structure and function of claudins. (PMID: 18036336) Krause G. … Blasig I.E. (Biochim. Biophys. Acta 2008) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for CLDN22 Gene

Sources for CLDN22 Gene

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