CLDN22 Gene
protein-coding GIFtS: 43
GCID: GC04M184239
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claudin 22
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Aliases
for CLDN22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Claudin 221 2 | | CLDN211 2 | | Claudin-221 |
Export aliases for CLDN22 gene to outside databasesPrevious GC identifers: GC04U990095 GC04M184937 GC04M184615 GC04M184477 GC04M179999 |
Summaries
for CLDN22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CLDN22:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tightjunction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freelythrough the paracellular space between epithelial or endothelial cell sheets, and also play critical roles inmaintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene(GeneID: 80014) on the opposite strand. (provided by RefSeq, Aug 2010)
UniProtKB/Swiss-Prot: CLD22_HUMAN, Q8N7P3Function: Plays a major role in tight junction-specific obliteration of the intercellular space, throughcalcium-independent cell-adhesion activity (By similarity)
Gene Wiki entry for CLDN22
|
Genomic Views
for CLDN22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLDN22 gene promoter:
FOXD3 AP-2gamma C/EBPalpha Evi-1 E47 AP-2beta Hand1 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLDN22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q35.1 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q35.1CLDN22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M184239: view genomic region
(about GC identifiers)
Start:
|
184,239,220 bp from pter |
End:
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184,241,927 bp from pter |
Size:
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2,708 bases |
Orientation:
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minus strand |
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Proteins
for CLDN22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLD22_HUMAN, Q8N7P3 (See
protein sequence)Recommended Name: Claudin-22 Size: 220 amino acids; 24509 Da
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (Bysimilarity)Explore the universe of human proteins at neXtProt for CLDN22: NX_Q8N7P3
CLDN22 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001104789.1
ENSEMBL proteins: ENSP00000318113 Reactome Protein details: Q8N7P3
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CLDN22 for ontologies About GeneDecksing
CLDN22 Antibody Products:
Assay Products for CLDN22: |
Protein
Domains /
Families
for CLDN22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLDN22 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N7P3ProtoNet protein and cluster: Q8N7P3 1 Blocks protein family: IPB006187 Claudin family signature
UniProtKB/Swiss-Prot: CLD22_HUMAN, Q8N7P3Similarity: Belongs to the claudin family |
Function
for CLDN22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CLD22_HUMAN, Q8N7P3Function: Plays a major role in tight junction-specific obliteration of the intercellular space, throughcalcium-independent cell-adhesion activity (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN22
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN22 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- | | GO:0042802 | identical protein binding |
ISS | -- |
CLDN22 for ontologies About GeneDecksing
|
Pathways & Interactions
for CLDN22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell-cell junction organization | | | 2 | Hepatitis C | | | 3 | Leukocyte transendothelial migration | | | 4 | Tight junction | | | 5 | Cell adhesion molecules (CAMs) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for CLDN22
4 
Kegg Pathways (Kegg details for CLDN22):
CLDN22 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN22
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/25 Interacting proteins for CLDN22 (ENSP000003181134) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016338 | calcium-independent cell-cell adhesion |
ISS | -- | | GO:0034329 | cell junction assembly |
TAS | -- | | GO:0045216 | cell-cell junction organization |
TAS | -- | | GO:0070830 | tight junction assembly |
TAS | -- |
CLDN22 for ontologies About GeneDecksing
|
Drugs & Compounds
for CLDN22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CLDN22
1 HMDB Compound for CLDN22 About this table
Search CenterWatch for drugs/clinical trials and news about CLDN22 / CLD22
|
Transcripts
for CLDN22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLDN22 gene: NM_001111319.1 Unigene Cluster for CLDN22: Claudin 22 Hs.712634 [show with all ESTs]Unigene Representative Sequence: BG1149781 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000323319(uc010isa.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN22 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN22
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CLDN22 (NM_001111319) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLDN22 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLDN22 |
Additional cDNA sequence: AK303864.1 2 DOTS entries: DT.100776397 DT.442412 24/120 AceView cDNA sequences (see all 120): F09729 BG566150 CB143347 BX505401 AL832424 BF512875 AW589643 AI341277 BU552462 AI569345 AV681710 BC017957 AA774954 AK127061 BM471272 BG034470 AW303614 CA429789 BM670729 BM473522 BC053873 BQ029441 BX505400 AW517719
GeneLoc Exon Structure
|
Expression
for CLDN22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLDN22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CLDN22 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.712634
SABiosciences Custom PCR Arrays for CLDN22
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN22
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CLDN22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN22 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN22 |
Orthologs
for CLDN22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CLDN22 gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for CLDN22 (if available)
TreeFam Gene Tree for CLDN22 (if available) |
Paralogs
for CLDN22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLDN22 gene
- CLDN182 CLDN252 CLDN242
18 SIMAP similar genes for CLDN22 using alignment to 1 protein entry: CLD22_HUMAN:CLDN24 CLDN25 CLDN8 CLDN14 CLDN2 CLDN3
CLDN4 CLDN9 CLDN1 CLDN17 CLDN6 CLDN7
CLDN10 CLDN20 CLDN15 CLDN19 CLDN5 CLDN18
CLDN22 for paralogs About GeneDecksing
|
Genomic Variants
for CLDN22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN22 |
|
Disorders
/ Diseases
for CLDN22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLDN22 for disorders About GeneDecksing
3  diseases for CLDN22: About MalaCardshepatitis c gastric cancer hepatitis
Export disorders for CLDN22 gene to outside databases
|
Publications
for CLDN22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLDN22 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLDN22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PubMed id 12736707)1, 9 Katoh M. and Katoh M. (2003)
- The claudins. (PubMed id 19706201)1 Lal-Nag M. and Morin P.J. (2009)
- Structure and function of claudins. (PubMed id 18036336)1 Krause G....Blasig I.E. (2008)
- Tight junction proteins. (PubMed id 12475568)1 Gonzalez-Mariscal L....Jaramillo B.E. (2003)
- Claudin-based barrier in simple and stratified cellular sheets. (PubMed id 12231346)1 Tsukita S. and Furuse M. (2002)
- The roles of claudin superfamily proteins in paracellular transport. (PubMed id 11247307)1 Heiskala M....Yang Y. (2001)
- Multifunctional strands in tight junctions. (PubMed id 11283726)1 Tsukita S....Itoh M. (2001)
- Tight junctions of the blood-brain barrier. (PubMed id 10690502)1 Kniesel U. and Wolburg H. (2000)
|
External Searches for CLDN22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CLDN22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLDN22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLDN22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLDN22 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CLDN22 gene:
Search GeneIP for patents involving CLDN22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLDN22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLDN22 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN22 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN22 | | | OriGene Protein Over-expression Lysate for CLDN22 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLDN22 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN22 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN22 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CLDN22 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLDN22 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN22 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN22 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN22 |
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 | | | CLDN22 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN22 |
|  |  |  | | | | ThermoFisher Antibody for CLDN22 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLDN22 |
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