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CLDN22 Gene

protein-coding   GIFtS: 39
GCID: GC04M184239

Claudin 22

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Claudin 221 2
CLDN212
claudin-222

External Ids:    HGNC: 20441   Entrez Gene: 538422   Ensembl: ENSG000001773007   UniProtKB: Q8N7P33   

Export aliases for CLDN22 gene to outside databases

Previous GC identifers: GC04U990095 GC04M184937 GC04M184615 GC04M184477 GC04M179999


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLDN22 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the
WWC2 gene (GeneID: 80014) on the opposite strand. (provided by RefSeq, Aug 2010)

GeneCards Summary for CLDN22 Gene:
CLDN22 (claudin 22) is a protein-coding gene. Diseases associated with CLDN22 include endotheliitis, and hepatitis c. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is ENSG00000262302.

UniProtKB/Swiss-Prot: CLD22_HUMAN, Q8N7P3
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CLDN22 gene promoter:
         FOXD3   AP-2gamma   C/EBPalpha   Evi-1   E47   AP-2beta   Hand1   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CLDN22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35.1

CLDN22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN22 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M184239:  view genomic region     (about GC identifiers)

Start:
184,239,220 bp from pter      End:
184,241,927 bp from pter
Size:
2,708 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLD22_HUMAN, Q8N7P3 (See protein sequence)
Recommended Name: Claudin-22  
Size: 220 amino acids; 24509 Da

Explore the universe of human proteins at neXtProt for CLDN22: NX_Q8N7P3

REFSEQ proteins: NP_001104789.1  
ENSEMBL proteins: 
 ENSP00000318113  
Reactome Protein details: Q8N7P3

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
CLDN: Claudins

3 InterPro protein domains:
 IPR017974 Claudin_CS
 IPR006187 Claudin
 IPR004031 PMP22/EMP/MP20/Claudin

Graphical View of Domain Structure for InterPro Entry Q8N7P3

ProtoNet protein and cluster: Q8N7P3

1 Blocks protein domain: IPB006187 Claudin family signature

UniProtKB/Swiss-Prot: CLD22_HUMAN, Q8N7P3
Similarity: Belongs to the claudin family


CLDN22 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CLD22_HUMAN, Q8N7P3
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005198structural molecule activity IEA--
GO:0042802identical protein binding ISS--
     
CLDN22 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CLD22_HUMAN, Q8N7P3: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein
(By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
extracellular1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0005923tight junction ISS--
GO:0016021integral component of membrane IEA--

CLDN22 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CLDN22 About    
See pathways by source

SuperPathContained pathways About
1Cell junction organization
Cell junction organization0.70
Cell-Cell communication0.64
Cell-cell junction organization0.70
Tight junction interactions0.51
2Tight junction
Tight junction
3Leukocyte transendothelial migration
Leukocyte transendothelial migration
4Hepatitis C
Hepatitis C
5Cell adhesion molecules (CAMs)
Cell adhesion molecules (CAMs)

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for CLDN22
    Tight junction interactions


4 Kegg Pathways  (Kegg details for CLDN22):
    Cell adhesion molecules (CAMs)
Tight junction
Leukocyte transendothelial migration
Hepatitis C


CLDN22 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLDN22
Interactions:

    Search GeneGlobe Interaction Network for CLDN22

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CLDN22 (ENSP000003181134) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
InteractantInteraction Details
GeneCardExternal ID(s)
CLDN1ENSP000002955224STRING: ENSP00000295522
CLDN10ENSP000002993394STRING: ENSP00000299339
CLDN11ENSP000000647244STRING: ENSP00000064724
CLDN14ENSP000003392924STRING: ENSP00000339292
CLDN15ENSP000003088704STRING: ENSP00000308870
About this table

Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016338calcium-independent cell-cell adhesion ISS--
GO:0034329cell junction assembly TAS--
GO:0045216cell-cell junction organization TAS--
GO:0070830tight junction assembly TAS--

CLDN22 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CLDN22 (CLD22)

1 HMDB Compound for CLDN22    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CLDN22 gene: 
NM_001111319.1  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000323319(uc010isa.1)
miRNA
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hsa-miR-361-5p hsa-miR-16-1* hsa-miR-3074-3p hsa-miR-374a* hsa-miR-183* hsa-miR-4325 hsa-miR-889 hsa-miR-186
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Selected AceView cDNA sequences (see all 120):

F09729 AW517719 AV681710 AW303614 CA446513 BX505401 BG566150 AA774954 
AW195363 BC017957 AK127061 BQ029441 BM473522 AL832424 BF512875 AW589643 
BM471272 BM670729 BG034470 CA429789 CB143347 BU552462 BX505400 AI341277 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CLDN22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CLDN22 Expression
About this image

CLDN22 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN22

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CLDN22 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cldn221 , 5 claudin 221, 5 78.96(n)1
76.5(a)1
  8 (26.91 cM)5
756771  NM_029383.11  NP_083659.11 
 478244825 
chicken
(Gallus gallus)
Aves LOC1008588881 claudin-22-like 73.33(n)
72.56(a)
  100858888  XM_004941070.1  XP_004941127.1 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
70(a)
1 → many
5(113896649-113897263)
tropical clawed frog
(Xenopus tropicalis)
Amphibia cldn221 claudin 22 65.58(n)
61.86(a)
  100485528  XM_002934258.2  XP_002934304.1 
zebrafish
(Danio rerio)
Actinopterygii si:dkey-98f17.31 si:dkey-98f17.3 54.59(n)
44.04(a)
  793143  NM_001122706.1  NP_001116178.1 


ENSEMBL Gene Tree for CLDN22 (if available)
TreeFam Gene Tree for CLDN22 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CLDN22 gene
ENSG000002623022  CLDN102  CLDN182  CLDN252  CLDN152  CLDN242  
18 SIMAP similar genes for CLDN22 using alignment to 1 protein entry:     CLD22_HUMAN:
CLDN24    CLDN25    CLDN8    CLDN14    CLDN2    CLDN3
CLDN4    CLDN9    CLDN1    CLDN17    CLDN7    CLDN10
CLDN20    CLDN6    CLDN15    CLDN19    CLDN5    CLDN18

CLDN22 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CLDN22
DNA2.0 Custom Variant and Variant Library Synthesis for CLDN22

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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3 diseases for CLDN22:    
About MalaCards
endotheliitis    hepatitis c    hepatitis


CLDN22 for disorders           About GeneDecksing


Export disorders for CLDN22 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CLDN22 gene integrated from 10 sources:
(articles sorted by number of sources associating them with CLDN22)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PubMed id 12736707)1, 9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2003)
  4. The claudins. (PubMed id 19706201)1 Lal-Nag M. and Morin P.J. (Genome Biol. 2009)
  5. Structure and function of claudins. (PubMed id 18036336)1 Krause G....Blasig I.E. (Biochim. Biophys. Acta 2008)
  6. Tight junction proteins. (PubMed id 12475568)1 GonzA!lez-Mariscal L....Jaramillo B.E. (Prog. Biophys. Mol. Biol. 2003)
  7. Claudin-based barrier in simple and stratified cellular sheets. (PubMed id 12231346)1 Tsukita S. and Furuse M. (Curr. Opin. Cell Biol. 2002)
  8. The roles of claudin superfamily proteins in paracellular transport. (PubMed id 11247307)1 Heiskala M....Yang Y. (Traffic 2001)
  9. Multifunctional strands in tight junctions. (PubMed id 11283726)1 Tsukita S....Itoh M. (Nat. Rev. Mol. Cell Biol. 2001)
  10. Tight junctions of the blood-brain barrier. (PubMed id 10690502)1 Kniesel U. and Wolburg H. (Cell. Mol. Neurobiol. 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 53842 HGNC: 2044 AceView: BOMB Ensembl:ENSG00000177300 euGenes: HUgn53842
ECgene: CLDN22 Kegg: 53842 H-InvDB: CLDN22

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CLDN22 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CLDN22 gene:
Search GeneIP for patents involving CLDN22

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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