CLDN20 Gene
protein-coding GIFtS: 49
GCID: GC06P155677
|
|
claudin 20
| |
Aliases
for CLDN20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Claudin 201 2 | | Claudin-201 |
Export aliases for CLDN20 gene to outside databasesPrevious GC identifers: GC06P155146 GC06M155480 GC06P155540 GC06P155616 GC06P155627 GC06P153147 |
Summaries
for CLDN20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CLDN20:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tightjunction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freelythrough the paracellular space between epithelial or endothelial cell sheets, and also play critical roles inmaintaining cell polarity and signal transductions. (provided by RefSeq, Jun 2010)
UniProtKB/Swiss-Prot: CLD20_HUMAN, P56880Function: Plays a major role in tight junction-specific obliteration of the intercellular space, throughcalcium-independent cell-adhesion activity (By similarity)
Gene Wiki entry for CLDN20
|
Genomic Views
for CLDN20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLDN20 gene promoter:
Pbx1a Brachyury YY1 PPAR-gamma1 CBF-A CBF-B CP1A PPAR-gamma2 NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLDN20
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN20 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q25 Ensembl cytogenetic band: 6q25.3 HGNC cytogenetic band: 6q25CLDN20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P155677: view genomic region
(about GC identifiers)
Start:
|
155,585,147 bp from pter |
End:
|
155,597,682 bp from pter |
Size:
|
12,536 bases |
Orientation:
|
plus strand |
|
Proteins
for CLDN20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLD20_HUMAN, P56880 (See
protein sequence)Recommended Name: Claudin-20 Size: 219 amino acids; 23515 Da
Subcellular location: Cell junction, tight junction. Cell membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for CLDN20: NX_P56880
CLDN20 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001001346.1
ENSEMBL proteins: ENSP00000356133 Reactome Protein details: P56880
Human Recombinant Protein Products for CLDN20:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CLDN20 for ontologies About GeneDecksing
CLDN20 Antibody Products:
Assay Products for CLDN20: |
Protein
Domains /
Families
for CLDN20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLDN20 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P56880ProtoNet protein and cluster: P56880 1 Blocks protein family: IPB006187 Claudin family signature
UniProtKB/Swiss-Prot: CLD20_HUMAN, P56880Similarity: Belongs to the claudin family |
Function
for CLDN20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CLD20_HUMAN, P56880Function: Plays a major role in tight junction-specific obliteration of the intercellular space, throughcalcium-independent cell-adhesion activity (By similarity) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- | | GO:0042802 | identical protein binding |
ISS | -- |
CLDN20 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN20 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN20
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CLDN20 (NM_001001346) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLDN20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN20 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN20 |
|
Pathways & Interactions
for CLDN20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell-cell junction organization | | | 2 | Sertoli-Sertoli Cell Junction Dynamics | | | 3 | Hepatitis C | | | 4 | Leukocyte transendothelial migration | | | 5 | Tight junction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN20
4 
Reactome Pathways for CLDN20
4 
Kegg Pathways (Kegg details for CLDN20):
CLDN20 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN20
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/26 Interacting proteins for CLDN20 (ENSP000003561334) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016338 | calcium-independent cell-cell adhesion |
ISS | -- | | GO:0034329 | cell junction assembly |
TAS | -- | | GO:0045216 | cell-cell junction organization |
TAS | -- | | GO:0070830 | tight junction assembly |
TAS | -- |
CLDN20 for ontologies About GeneDecksing
|
Drugs & Compounds
for CLDN20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CLDN20
1 HMDB Compound for CLDN20 About this table
Search CenterWatch for drugs/clinical trials and news about CLDN20 / CLD20
|
Transcripts
for CLDN20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLDN20 gene: NM_001001346.3 Unigene Cluster for CLDN20: Claudin 20 Hs.567491 [show with all ESTs]Unigene Representative Sequence: BC0208381 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000367165(uc003qql.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN20 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN20
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CLDN20 (NM_001001346) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLDN20 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN20 |
Additional cDNA sequence: BC020838.1 1 DOTS entry: DT.95099967 5 AceView cDNA sequences: BC020838 NM_001001346 BX283198 BF571834 BG980450
GeneLoc Exon Structure
|
Expression
for CLDN20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLDN20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCTGGAGG
About this image
See CLDN20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLDN20
SOURCE GeneReport for Unigene cluster: Hs.567491
SABiosciences Custom PCR Arrays for CLDN20
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN20
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLDN20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN20 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN20 |
Orthologs
for CLDN20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CLDN20 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for CLDN20 (if available)
TreeFam Gene Tree for CLDN20 (if available) |
Paralogs
for CLDN20 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLDN20 gene
- CLDN92 CLDN42 CLDN82 CLDN172 CLDN52 CLDN22 CLDN102 CLDN152
- CLDN32 CLDN12 CLDN142 CLDN192 CLDN62 CLDN72
17 SIMAP similar genes for CLDN20 using alignment to 1 protein entry: CLD20_HUMAN:CLDN7 CLDN2 CLDN4 CLDN6 CLDN1 CLDN14
CLDN19 CLDN3 CLDN18 CLDN10 CLDN9 CLDN15
CLDN5 CLDN8 CLDN17 CLDN24 CLDN22
CLDN20 for paralogs About GeneDecksing
|
Genomic Variants
for CLDN20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLDN20 (155585147 - 155597682 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLDN20: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN20 |
|
Disorders
/ Diseases
for CLDN20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLDN20 for disorders About GeneDecksing
3  diseases for CLDN20: About MalaCardshepatitis c hepatitis retinitis
Export disorders for CLDN20 gene to outside databases
|
Publications
for CLDN20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLDN20 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with CLDN20) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The claudin gene family: expression in normal and neoplastic tissues. (PubMed id 16836752)1, 3 Hewitt K.J....Morin P.J. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier. (PubMed id 17679949)1, 9 Rizzolo L.J....Zhang H. (2007)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- The claudins. (PubMed id 19706201)1 Lal-Nag M. and Morin P.J. (2009)
- Biology of claudins. (PubMed id 18480174)1 Angelow S....Yu A.S. (2008)
- Structure and function of claudins. (PubMed id 18036336)1 Krause G....Blasig I.E. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Tight junction proteins. (PubMed id 12475568)1 Gonzalez-Mariscal L....Jaramillo B.E. (2003)
|
External Searches for CLDN20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CLDN20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLDN20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLDN20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLDN20 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CLDN20 gene:
Search GeneIP for patents involving CLDN20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLDN20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLDN20 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN20 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN20 | | | OriGene Protein Over-expression Lysate for CLDN20 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLDN20 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN20 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN20 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLDN20 | | OriGene Custom Protein Services for CLDN20 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLDN20 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN20 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN20 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN20 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CLDN20 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CLDN20 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN20 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CLDN20 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN20 |
| |  | |
|
|
|
