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Aliases for CLDN20 Gene

Aliases for CLDN20 Gene

  • Claudin 20 2 3 5

External Ids for CLDN20 Gene

Previous GeneCards Identifiers for CLDN20 Gene

  • GC06P155146
  • GC06M155480
  • GC06P155540
  • GC06P155616
  • GC06P155627
  • GC06P155677
  • GC06P153147

Summaries for CLDN20 Gene

Entrez Gene Summary for CLDN20 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010]

GeneCards Summary for CLDN20 Gene

CLDN20 (Claudin 20) is a Protein Coding gene. Among its related pathways are Cell junction organization and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN9.

UniProtKB/Swiss-Prot for CLDN20 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Wiki entry for CLDN20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN20 Gene

Genomics for CLDN20 Gene

Regulatory Elements for CLDN20 Gene

Enhancers for CLDN20 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLDN20 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLDN20 Gene

155,264,013 bp from pter
155,276,548 bp from pter
12,536 bases
Plus strand

Genomic View for CLDN20 Gene

Genes around CLDN20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN20 Gene

Proteins for CLDN20 Gene

  • Protein details for CLDN20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for CLDN20 Gene

    219 amino acids
    Molecular mass:
    23515 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN20 Gene

Proteomics data for CLDN20 Gene at MOPED

Post-translational modifications for CLDN20 Gene

No Post-translational modifications

Other Protein References for CLDN20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN20 Gene

Domains & Families for CLDN20 Gene

Gene Families for CLDN20 Gene

Protein Domains for CLDN20 Gene

Suggested Antigen Peptide Sequences for CLDN20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the claudin family.
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN20: view

Function for CLDN20 Gene

Molecular function for CLDN20 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN20 Gene

Localization for CLDN20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN20 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CLDN20 Gene COMPARTMENTS Subcellular localization image for CLDN20 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CLDN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CLDN20: view

Pathways & Interactions for CLDN20 Gene

genes like me logo Genes that share pathways with CLDN20: view

Interacting Proteins for CLDN20 Gene

Gene Ontology (GO) - Biological Process for CLDN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034329 cell junction assembly TAS --
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with CLDN20: view

No data available for SIGNOR curated interactions for CLDN20 Gene

Drugs & Compounds for CLDN20 Gene

(1) Drugs for CLDN20 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CLDN20: view

Transcripts for CLDN20 Gene

mRNA/cDNA for CLDN20 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLDN20 Gene

Claudin 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN20 Gene

No ASD Table

Relevant External Links for CLDN20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLDN20 Gene

mRNA expression in normal human tissues for CLDN20 Gene

mRNA differential expression in normal tissues according to GTEx for CLDN20 Gene

This gene is overexpressed in Nerve - Tibial (x4.0).

SOURCE GeneReport for Unigene cluster for CLDN20 Gene Hs.567491

genes like me logo Genes that share expression patterns with CLDN20: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CLDN20 Gene

Orthologs for CLDN20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN20 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLDN20 35
  • 81.58 (n)
  • 74.89 (a)
CLDN20 36
  • 75 (a)
(Canis familiaris)
Mammalia CLDN20 35
  • 88.74 (n)
  • 88.58 (a)
CLDN20 36
  • 89 (a)
(Mus musculus)
Mammalia Cldn20 35
  • 79.91 (n)
  • 74.43 (a)
Cldn20 16
Cldn20 36
  • 74 (a)
(Pan troglodytes)
Mammalia CLDN20 35
  • 99.85 (n)
  • 100 (a)
CLDN20 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cldn20 35
  • 80.52 (n)
  • 77.17 (a)
(Monodelphis domestica)
Mammalia CLDN20 36
  • 75 (a)
(Gallus gallus)
Aves CLDN20 35
  • 73.06 (n)
  • 67.12 (a)
CLDN20 36
  • 67 (a)
(Anolis carolinensis)
Reptilia CLDN20 36
  • 68 (a)
(Danio rerio)
Actinopterygii LOC101886267 35
  • 59.67 (n)
  • 57.53 (a)
CLDN20 (1 of 2) 36
  • 49 (a)
CU695076.1 36
  • 55 (a)
Species with no ortholog for CLDN20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN20 Gene

Gene Tree for CLDN20 (if available)
Gene Tree for CLDN20 (if available)

Paralogs for CLDN20 Gene

Paralogs for CLDN20 Gene

(17) SIMAP similar genes for CLDN20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLDN20: view

Variants for CLDN20 Gene

Structural Variations from Database of Genomic Variants (DGV) for CLDN20 Gene

Variant ID Type Subtype PubMed ID
nsv886789 CNV Gain 21882294
nsv886790 CNV Loss 21882294

Variation tolerance for CLDN20 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for CLDN20 Gene

Disorders for CLDN20 Gene

Relevant External Links for CLDN20

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLDN20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDN20 Gene

Publications for CLDN20 Gene

  1. The claudin gene family: expression in normal and neoplastic tissues. (PMID: 16836752) Hewitt K.J. … Morin P.J. (BMC Cancer 2006) 2 3 67
  2. Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier. (PMID: 17679949) Rizzolo L.J. … Zhang H. (Mol. Vis. 2007) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. The claudins. (PMID: 19706201) Lal-Nag M. … Morin P.J. (Genome Biol. 2009) 3

Products for CLDN20 Gene

Sources for CLDN20 Gene