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CLDN2 Gene

protein-coding   GIFtS: 59
GCID: GC0XP106163

Claudin 2

  Search for CLDN2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Claudin 21 2
SP822 3
claudin-22

External Ids:    HGNC: 20411   Entrez Gene: 90752   Ensembl: ENSG000001653767   OMIM: 3005205   UniProtKB: P577393   

Export aliases for CLDN2 gene to outside databases

Previous GC identifers: GC0XP101455 GC0XP103062 GC0XP104176 GC0XP104915 GC0XP105949 GC0XP106050 GC0XP095771


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLDN2 Gene:
This gene product belongs to the claudin protein family whose members have been identified as major integral
membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner
and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the
intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for
this gene.(provided by RefSeq, Jan 2010)

GeneCards Summary for CLDN2 Gene:
CLDN2 (claudin 2) is a protein-coding gene. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is CLDN4.

UniProtKB/Swiss-Prot: CLD2_HUMAN, P57739
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLDN2 gene promoter:
         RORalpha1   AREB6   STAT5B   AML1a   Pax-5   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLDN2 promoter sequence
   Search Chromatin IP Primers for CLDN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3-q23   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.3-q23

CLDN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP106163:  view genomic region     (about GC identifiers)

Start:
106,143,394 bp from pter      End:
106,174,091 bp from pter
Size:
30,698 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLD2_HUMAN, P57739 (See protein sequence)
Recommended Name: Claudin-2  
Size: 230 amino acids; 24549 Da
Subunit: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1,
homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity)
Secondary accessions: B2R6B9

Explore the universe of human proteins at neXtProt for CLDN2: NX_P57739

Explore proteomics data for CLDN2 at MOPED

Post-translational modifications: 

  • The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLDN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001164563.1  NP_001164566.1  NP_065117.1  

    ENSEMBL proteins: 
     ENSP00000336571   ENSP00000441283   ENSP00000443230  
    Reactome Protein details: P57739

    CLDN2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CLDN2

     
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    Search eBioscience for ELISAs for CLDN2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR005411 Claudin2
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry P57739

    ProtoNet protein and cluster: P57739

    2 Blocks protein domains:
    IPB005411 Claudin-2 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD2_HUMAN, P57739
    Similarity: Belongs to the claudin family


    Find genes that share domains with CLDN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD2_HUMAN, P57739
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding ISS--
         
    Find genes that share ontologies with CLDN2           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cldn2):
     homeostasis/metabolism  renal/urinary system 

    Find genes that share phenotypes with CLDN2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CLDN2: Cldn2tm1Muto Cldn2tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLDN2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLDN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLDN2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLDN2

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    Selected qRT-PCR Assays for microRNAs that regulate CLDN2 (see all 31):
    hsa-miR-194* hsa-miR-3910 hsa-miR-4291 hsa-miR-4272 hsa-miR-15a hsa-miR-331-3p hsa-miR-548s hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidCLDN2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLDN2

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN2

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12003) for CLDN2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLD2_HUMAN, P57739: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CLDN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLDN2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    5Tight junction
    Tight junction


    Find genes that share SuperPaths with CLDN2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLDN2
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN2
        Cell adhesion Tight junctions

    1 Reactome Pathway for CLDN2
        Tight junction interactions


    4 Kegg Pathways  (Kegg details for CLDN2):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN2: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CLDN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLDN2 (P577392, 3 ENSP000003365714) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-68121 I2D: score=5 STRING: ENSP00000377582
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    WNK4Q96J923, ENSP000002469144I2D: score=1 STRING: ENSP00000246914
    MDFIQ997503I2D: score=1 
    PLSCR1O151623I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--

    Find genes that share ontologies with CLDN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLDN2 (CLD2)

    1 HMDB Compound for CLDN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for CLDN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 3 17951470 (1), 18287530 (1)



    Find genes that share compounds with CLDN2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLDN2 gene (3 alternative transcripts): 
    NM_001171092.1  NM_001171095.1  NM_020384.3  

    Unigene Cluster for CLDN2:

    Claudin 2
    Hs.522746  [show with all ESTs]
    Unigene Representative Sequence: NM_001171092
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336803(uc004emt.2) ENST00000541806(uc004emq.1) ENST00000540876(uc022ccc.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CLDN2 (see all 31):
    hsa-miR-194* hsa-miR-3910 hsa-miR-4291 hsa-miR-4272 hsa-miR-15a hsa-miR-331-3p hsa-miR-548s hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidCLDN2 3' UTR sequence
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    Additional mRNA sequence: 

    AF177340.1 AF250558.1 AK075371.1 AK075405.1 AK312515.1 AY358474.1 BC014424.1 

    7 DOTS entries:

    DT.408483  DT.209196  DT.121291623  DT.100746819  DT.121291643  DT.121291640  DT.121291644 

    Selected AceView cDNA sequences (see all 84):

    CA389170 AF250558 NM_020384 BC014424 AA973123 AA552647 AI815042 AI659323 
    AI685439 AF177340 AI343787 AY358474 BC071747 BM852012 AI953320 BU073403 
    AA593001 AK075405 AI285131 AI469683 BU073420 AI244378 AK075371 AA345449 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLDN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLDN2 Expression
    About this image


    CLDN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Proximal Tubule Cells Proximal Tubule
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Choroid Plexus
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Thymus (Hematopoietic System)
             Thymus
    CLDN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLDN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522746
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN2: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CLDN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn21 , 5 claudin 21, 5 87.1(n)1
    91.3(a)1
      X (61.35 cM)5
    127381  NM_016675.41  NP_057884.11 
     1398008285 
    chicken
    (Gallus gallus)
    Aves CLDN21 claudin 2 71.26(n)
    71.56(a)
      422292  NM_001277622.1  NP_001264551.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLDN26
    claudin 2
    66(a)
    1 ↔ 1
    GL343376.1(1049574-1050284)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004891701 claudin-2-like 63.77(n)
    58.26(a)
      100489170  XM_004916756.1  XP_004916813.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cldn26
    claudin 2
    41(a)
    1 ↔ 1
    21(36966135-36972763) ENSDARG00000044387


    ENSEMBL Gene Tree for CLDN2 (if available)
    TreeFam Gene Tree for CLDN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLDN2 gene
    CLDN42  CLDN92  CLDN82  CLDN202  CLDN172  CLDN52  CLDN12  CLDN142  
    CLDN32  CLDN62  CLDN72  CLDN192  
    18 SIMAP similar genes for CLDN2 using alignment to 1 protein entry:     CLD2_HUMAN:
    CLDN7    CLDN3    CLDN14    CLDN9    CLDN4    CLDN6
    CLDN17    CLDN20    CLDN8    CLDN19    CLDN5    CLDN1
    CLDN10    CLDN24    CLDN18    CLDN22    CLDN15    CLDN25

    Find genes that share paralogs with CLDN2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLDN2 (see all 428)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823973431,2
    C--106113138(+) CACTTC/TGCCTC 1 -- us2k10--------
    rs59627721,2
    C,H--106113167(+) TTTTTG/TGGGGG 1 -- us2k1 trp36Minor allele frequency- T:0.07WA NA 15
    rs1429948911,2
    C--106113500(+) CCCCAC/TTTTAC 1 -- us2k10--------
    rs1861254611,2
    --106113747(+) TCCCAA/GCTAGG 1 -- us2k10--------
    rs1881016371,2
    --106113812(+) TCATCA/GTTTTG 1 -- us2k10--------
    rs1168176711,2
    C--106113961(+) ACCTCC/TTTTGT 1 -- us2k10--------
    rs78897251,2
    C,F,H--106114033(+) GTATAG/AGAAAG 1 -- us2k1 trp311Minor allele frequency- A:0.16NS EA NA WA 1370
    rs1853602321,2
    --106114133(+) GGTGTC/TTGAGC 1 -- us2k10--------
    rs1410696131,2
    C--106114159(+) AATGAA/GAGTTT 1 -- us2k10--------
    rs1905644021,2
    --106114197(+) TCCAGA/CCAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLDN2 (106143394 - 106174091 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CLDN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv482964CNV Loss15286789
    esv2752312CNV Gain17911159

    Human Gene Mutation Database (HGMD): CLDN2
    Locus Specific Mutation Databases (LSDB): CLDN2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLDN2
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300520    OMIM disorders: --


    Find genes that share disorders with CLDN2           About GenesLikeMe

    8 Novoseek inferred disease relationships for CLDN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colitis ulcerative 47.7 5 19538319 (2), 17545772 (2), 16822808 (1)
    inflammatory bowel diseases 38.8 1 18711353 (1)
    adenocarcinoma 22.4 2 18500171 (1), 16505274 (1)
    tumors 11.6 8 18942115 (3), 15619213 (1), 18711353 (1), 19245593 (1) (see all 5)
    carcinoma 11.3 1 18097572 (1)
    inflammation 1.35 1 19214581 (1)
    necrosis 0 2 16822808 (1), 20177070 (1)
    cancer 0 7 18586689 (5), 18500171 (1), 17970035 (1)


    Export disorders for CLDN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLDN2 gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with CLDN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SUMOylation of claudin-2. (PubMed id 22731716)1, 2 Van Itallie C.M.... Anderson J.M. (Ann. N. Y. Acad. Sci. 2012)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Cloning of the human claudin-2 5'-flanking region revealed a TATA- less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor- 1alpha. (PubMed id 11934881)1, 2 Sakaguchi T....Reinecker H.-C. (J. Biol. Chem. 2002)
    8. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    9. Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. (PubMed id 15389642)1, 9 Escaffit F....Beaulieu J.F. (J. Cell. Physiol. 2005)
    10. Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity. (PubMed id 14751232)1, 9 Mankertz J....Schulzke J.D. (Biochem. Biophys. Res. Commun. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9075 HGNC: 2041 AceView: CLDN2 Ensembl:ENSG00000165376 euGenes: HUgn9075
    ECgene: CLDN2 Kegg: 9075 H-InvDB: CLDN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLDN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CLDN2 gene:
    Search GeneIP for patents involving CLDN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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