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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN2 Gene

protein-coding   GIFtS: 59
GCID: GC0XP106163

Claudin 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Claudin 21 2
SP822 3
claudin-22

External Ids:    HGNC: 20411   Entrez Gene: 90752   Ensembl: ENSG000001653767   OMIM: 3005205   UniProtKB: P577393   

Export aliases for CLDN2 gene to outside databases

Previous GC identifers: GC0XP101455 GC0XP103062 GC0XP104176 GC0XP104915 GC0XP105949 GC0XP106050 GC0XP095771


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLDN2 Gene:
This gene product belongs to the claudin protein family whose members have been identified as major integral
membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner
and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the
intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for
this gene.(provided by RefSeq, Jan 2010)

GeneCards Summary for CLDN2 Gene: 
CLDN2 (claudin 2) is a protein-coding gene. Diseases associated with CLDN2 include biliary tract cancer, and cholecystitis, and among its related super-pathways are Cell-cell junction organization and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is CLDN4.

UniProtKB/Swiss-Prot: CLD2_HUMAN, P57739
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN2 gene promoter:
         RORalpha1   AREB6   STAT5B   AML1a   Pax-5   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLDN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLDN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3-q23   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.3-q23

CLDN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP106163:  view genomic region     (about GC identifiers)

Start:
106,143,394 bp from pter      End:
106,174,091 bp from pter
Size:
30,698 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLD2_HUMAN, P57739 (See protein sequence)
Recommended Name: Claudin-2  
Size: 230 amino acids; 24549 Da
Subunit: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1,
homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity)
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein
(By similarity)
Secondary accessions: B2R6B9

Explore the universe of human proteins at neXtProt for CLDN2: NX_P57739

Explore proteomics data for CLDN2 at MOPED 

Post-translational modifications:

  • UniProtKB: The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P57739

  • CLDN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLDN2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001164563.1  NP_001164566.1  NP_065117.1  

    ENSEMBL proteins: 
     ENSP00000336571   ENSP00000441283   ENSP00000443230  
    Reactome Protein details: P57739
    Human Recombinant Protein Products for CLDN2: 
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    OriGene Protein Over-expression Lysate for CLDN2
    OriGene MassSpec for CLDN2 
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    GenScript Custom Purified and Recombinant Proteins Services for CLDN2
    Novus Biologicals CLDN2 Proteins
    Novus Biologicals CLDN2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLDN2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane IEA--

    CLDN2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CLDN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR005411 Claudin2
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry P57739

    ProtoNet protein and cluster: P57739

    2 Blocks protein domains:
    IPB005411 Claudin-2 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD2_HUMAN, P57739
    Similarity: Belongs to the claudin family


    CLDN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD2_HUMAN, P57739
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding ISS--
         
    CLDN2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cldn2):
     homeostasis/metabolism  renal/urinary system 

    CLDN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CLDN2: Cldn2tm1Muto Cldn2tm1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLDN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLDN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLDN2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLDN2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN2
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN2 (see all 31):
    hsa-miR-194* hsa-miR-3910 hsa-miR-4291 hsa-miR-4272 hsa-miR-15a hsa-miR-331-3p hsa-miR-548s hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidCLDN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLDN2
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): CLDN2 (NM_020384)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLDN2 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell-cell junction organization0.69
    Cell-Cell communication0.64
    Cell junction organization0.69
    Tight junction interactions0.49
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    5Tight junction
    Tight junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CLDN2
        Cell adhesion Tight junctions

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN2
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN2
        Cell adhesion Tight junctions

    4        Reactome Pathways for CLDN2
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN2):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLDN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for CLDN2 (P577392, 3 ENSP000003365714) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-68121 I2D: score=5 STRING: ENSP00000377582
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    WNK4Q96J923, ENSP000002469144I2D: score=1 STRING: ENSP00000246914
    MDFIQ997503I2D: score=1 
    PLSCR1O151623I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--

    CLDN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLDN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN2 (CLD2)

    1 HMDB Compound for CLDN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for CLDN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 3 17951470 (1), 18287530 (1)

    Search CenterWatch for drugs/clinical trials and news about CLDN2 / CLD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLDN2 gene (3 alternative transcripts): 
    NM_001171092.1  NM_001171095.1  NM_020384.3  

    Unigene Cluster for CLDN2:

    Claudin 2
    Hs.522746  [show with all ESTs]
    Unigene Representative Sequence: NM_001171092
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336803(uc004emt.2) ENST00000541806(uc004emq.1) ENST00000540876(uc022ccc.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN2
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN2 (see all 31):
    hsa-miR-194* hsa-miR-3910 hsa-miR-4291 hsa-miR-4272 hsa-miR-15a hsa-miR-331-3p hsa-miR-548s hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidCLDN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN2
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    GenScript: all cDNA clones in your preferred vector (see all 3): CLDN2 (NM_020384)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN2
    Sirion Biotech Customized lentivirus for stable overexpression of CLDN2 
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    OriGene qPCR primer pairs and template standards for CLDN2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN2

    Additional mRNA sequence: 

    AF177340.1 AF250558.1 AK075371.1 AK075405.1 AK312515.1 AY358474.1 BC014424.1 

    7 DOTS entries:

    DT.408483  DT.209196  DT.121291623  DT.100746819  DT.121291643  DT.121291640  DT.121291644 

    24/84 AceView cDNA sequences (see all 84):

    AI285131 BM852012 AI953320 AK075405 AI244378 AA552647 AF177340 AI815042 
    BU073420 AI343787 AI685439 AA973123 AI659323 CA389170 AF250558 BU073403 
    AY358474 AA593001 AI469683 NM_020384 BC014424 BC071747 BE304667 BF821143 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN2 expression in normal human tissues (normalized intensities)      CLDN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLDN2 Expression
    About this image


    CLDN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Proximal Tubule Cells Proximal Tubule
             kidney ; cells in tubules   
             visceral organ/metanephros/calyx   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Choroid Plexus
             brain/forebrain/telencephalon   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   

    See CLDN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN2

    SOURCE GeneReport for Unigene cluster: Hs.522746
        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN2: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN2 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn21 , 5 claudin 21, 5 87.1(n)1
    91.3(a)1
      X (61.35 cM)5
    127381  NM_016675.41  NP_057884.11 
     1398008285 
    chicken
    (Gallus gallus)
    Aves CLDN21 claudin 2 71.41(n)
    71.56(a)
      422292  XM_420271.3  XP_420271.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLDN26
    Uncharacterized protein
    67(a)
    1 ↔ 1
    GL343376.1(1049574-1050284)
    zebrafish
    (Danio rerio)
    Actinopterygii cldn26
    claudin 2
    40(a)
    1 ↔ 1
    21(36966135-36972763)


    ENSEMBL Gene Tree for CLDN2 (if available)
    TreeFam Gene Tree for CLDN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN2 gene
    CLDN42  CLDN92  CLDN82  CLDN202  CLDN172  CLDN52  CLDN102  CLDN152  
    CLDN12  CLDN32  CLDN142  CLDN62  CLDN72  CLDN192  
    18 SIMAP similar genes for CLDN2 using alignment to 1 protein entry:     CLD2_HUMAN:
    CLDN7    CLDN3    CLDN14    CLDN9    CLDN4    CLDN6
    CLDN17    CLDN20    CLDN8    CLDN19    CLDN5    CLDN1
    CLDN10    CLDN24    CLDN18    CLDN22    CLDN15    CLDN25

    CLDN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/428 SNPs in CLDN2 are shown (see all 428)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823973431,2
    C--106113138(+) CACTTC/TGCCTC 1 -- us2k10--------
    rs59627721,2
    C,H--106113167(+) TTTTTG/TGGGGG 1 -- us2k1 trp36Minor allele frequency- T:0.07WA NA 15
    rs1429948911,2
    C--106113500(+) CCCCAC/TTTTAC 1 -- us2k10--------
    rs1861254611,2
    --106113747(+) TCCCAA/GCTAGG 1 -- us2k10--------
    rs1881016371,2
    --106113812(+) TCATCA/GTTTTG 1 -- us2k10--------
    rs1168176711,2
    C--106113961(+) ACCTCC/TTTTGT 1 -- us2k10--------
    rs78897251,2
    C,F,H--106114033(+) GTATAG/AGAAAG 1 -- us2k1 trp311Minor allele frequency- A:0.16NS EA NA WA 1370
    rs1853602321,2
    --106114133(+) GGTGTC/TTGAGC 1 -- us2k10--------
    rs1410696131,2
    C--106114159(+) AATGAA/GAGTTT 1 -- us2k10--------
    rs1905644021,2
    --106114197(+) TCCAGA/CCAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLDN2 (106143394 - 106174091 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CLDN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv482964CNV Loss15286789
    esv2752312CNV Gain17911159


    Locus Specific Mutation Databases (LSDB): CLDN2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLDN2
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300520    OMIM disorders: --

    20/28 diseases for CLDN2 (see all 28):    About MalaCards
    biliary tract cancer    cholecystitis    ulcerative colitis    cervical intraepithelial neoplasia
    epididymitis    inflammatory bowel disease    barrett's esophagus    hepatoblastoma
    prostate adenocarcinoma    crohn's disease    choroiditis    nasopharyngitis
    adenoiditis    hepatitis c    type 1 diabetes    adenocarcinoma
    lung adenocarcinoma    lung cancer    cervicitis    colon cancer


    CLDN2 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for CLDN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colitis ulcerative 47.7 5 19538319 (2), 17545772 (2), 16822808 (1)
    inflammatory bowel diseases 38.8 1 18711353 (1)
    adenocarcinoma 22.4 2 18500171 (1), 16505274 (1)
    tumors 11.6 8 18942115 (3), 15619213 (1), 18711353 (1), 19245593 (1) (see all 5)
    carcinoma 11.3 1 18097572 (1)
    inflammation 1.35 1 19214581 (1)
    necrosis 0 2 16822808 (1), 20177070 (1)
    cancer 0 7 18586689 (5), 18500171 (1), 17970035 (1)


    Export disorders for CLDN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN2 gene, integrated from 9 sources (see all 128):
    (articles sorted by number of sources associating them with CLDN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SUMOylation of claudin-2. (PubMed id 22731716)1, 2 Van Itallie C.M....Anderson J.M. (2012)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Cloning of the human claudin-2 5'-flanking region revealed a TATA- less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor- 1alpha. (PubMed id 11934881)1, 2 Sakaguchi T....Reinecker H.-C. (2002)
    8. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (1999)
    9. Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. (PubMed id 15389642)1, 9 Escaffit F....Beaulieu J.F. (2005)
    10. Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity. (PubMed id 14751232)1, 9 Mankertz J....Schulzke J.D. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9075 HGNC: 2041 AceView: CLDN2 Ensembl:ENSG00000165376 euGenes: HUgn9075
    ECgene: CLDN2 Kegg: 9075 H-InvDB: CLDN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLDN2 gene:
    Search GeneIP for patents involving CLDN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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