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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN2 Gene

protein-coding   GIFtS: 60
GCID: GC0XP106163

claudin 2
 Explore 29 diseases affiliated with
CLDN2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLDN2    

Aliases
for CLDN2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Claudin 21 2
SP822 3
Claudin-21

External Ids:    HGNC: 20411   Entrez Gene: 90752   Ensembl: ENSG000001653767   OMIM: 3005205   UniProtKB: P577393   

Export aliases for CLDN2 gene to outside databases

Previous GC identifers: GC0XP101455 GC0XP103062 GC0XP104176 GC0XP104915 GC0XP105949 GC0XP106050 GC0XP095771


Summaries
for CLDN2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLDN2:
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane
proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate
tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively
spliced transcript variants with different 5' untranslated region have been found for this gene.(provided by RefSeq,
Jan 2010)

UniProtKB/Swiss-Prot: CLD2_HUMAN, P57739
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN2


Genomic Views
for CLDN2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN2 gene promoter:
         RORalpha1   AREB6   STAT5B   AML1a   Pax-5   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLDN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLDN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3-q23   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.3-q23

CLDN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP106163:  view genomic region     (about GC identifiers)

Start:
 106,143,394 bp from pter      End:
 106,174,091 bp from pter
Size:
 30,698 bases      Orientation:
 plus strand

Proteins
for CLDN2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLD2_HUMAN, P57739 (See protein sequence)
Recommended Name: Claudin-2  
Size: 230 amino acids; 24549 Da
Subunit: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1,
homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity)
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By
similarity)
Secondary accessions: B2R6B9

Explore the universe of human proteins at neXtProt for CLDN2: NX_P57739

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P57739

    • CLDN2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001164563.1  NP_001164566.1  NP_065117.1  

    ENSEMBL proteins: 
     ENSP00000336571   ENSP00000441283   ENSP00000443230  
    Reactome Protein details: P57739
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: CLDN2
    OriGene Protein Over-expression Lysate (see all 2): CLDN2
    OriGene Custom Protein Services for CLDN2 
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    Novus Biologicals CLDN2 Proteins
    Novus Biologicals CLDN2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLDN2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane IEA--


    CLDN2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLDN2

    Protein Domains /
    Families
    for CLDN2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLDN2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017974 Claudin_CS
     IPR005411 Claudin2
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry P57739

    ProtoNet protein and cluster: P57739

    2 Blocks protein families:
    IPB005411 Claudin-2 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD2_HUMAN, P57739
    Similarity: Belongs to the claudin family


    Function
    for CLDN2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLD2_HUMAN, P57739
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN2
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN2 (see all 31):
    hsa-miR-194* hsa-miR-3910 hsa-miR-4291 hsa-miR-4272 hsa-miR-15a hsa-miR-331-3p hsa-miR-548s hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN2 (see all 7)
    OriGene shRNA RFP: CLDN2
    OriGene siRNA: CLDN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CLDN2

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): CLDN2 (NM_020384)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN2 

    Cell Line
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    Search LifeMap BioReagents cell lines for CLDN2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding ISS--


    CLDN2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for CLDN2: Cldn2tm1Muto Cldn2tm1Lex
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cldn2):
     homeostasis/metabolism  renal/urinary system 

    CLDN2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLDN2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Tight junction interactions0.49
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99
    3Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Epithelial Tight Junctions0.36
    4Hepatitis C
    		Hepatitis C1.00
    5Leukocyte transendothelial migration
    		Leukocyte transendothelial migration1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CLDN2
        Cell adhesion Tight junctions

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN2
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN2
        Cell adhesion Tight junctions

    4        Reactome Pathways for CLDN2
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN2):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLDN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for CLDN2 (P577392, 3 ENSP000003365714) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-68121 I2D: score=5 STRING: ENSP00000377582
    TJP1Q071573, ENSP000002815374I2D: score=3 STRING: ENSP00000281537
    WNK4Q96J923, ENSP000002469144I2D: score=1 STRING: ENSP00000246914
    MDFIQ997503I2D: score=1 
    PLSCR1O151623I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--


    CLDN2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLDN2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLDN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN2

    1 HMDB Compound for CLDN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for CLDN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 3 17951470 (1), 18287530 (1)

    Search CenterWatch for drugs/clinical trials and news about CLDN2 / CLD2 

    Transcripts
    for CLDN2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLDN2 gene (3 alternative transcripts): 
    NM_001171092.1  NM_001171095.1  NM_020384.3  

    Unigene Cluster for CLDN2:

    Claudin 2
    Hs.522746  [show with all ESTs]
    Unigene Representative Sequence: NM_001171092
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336803(uc004emt.2) ENST00000541806(uc004emq.1) ENST00000540876(uc022ccc.1)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN2
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN2 (see all 31):
    hsa-miR-194* hsa-miR-3910 hsa-miR-4291 hsa-miR-4272 hsa-miR-15a hsa-miR-331-3p hsa-miR-548s hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN2 (see all 7)
    OriGene shRNA RFP: CLDN2
    OriGene siRNA: CLDN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN2 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CLDN2 (NM_020384)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN2

    Additional cDNA sequence: 

    AF177340.1 AF250558.1 AK075371.1 AK075405.1 AK312515.1 AY358474.1 BC014424.1 

    7 DOTS entries:

    DT.408483  DT.209196  DT.121291623  DT.100746819  DT.121291643  DT.121291640  DT.121291644 

    24/84 AceView cDNA sequences (see all 84):

    AI685439 BU073403 AA593001 BC014424 AY358474 AF250558 AI659323 AI953320 
    AF177340 AI285131 AI469683 BC071747 BM852012 AI815042 AI343787 AK075405 
    AI244378 NM_020384 CA389170 BU073420 AA973123 AA552647 BG164062 CB999779 

    GeneLoc Exon Structure


    Expression
    for CLDN2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLDN2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyProximal TubuleProximal Tubule CellsKidney
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    KidneyBowman's CapsuleParietal Epithelial CellsKidney
    KidneyLoop of HenleLoop of Henle CellsKidney
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    BrainChoroid PlexusBrain
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CLDN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN2

    SOURCE GeneReport for Unigene cluster: Hs.522746
        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN2: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN2

    Orthologs
    for CLDN2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN2 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CLDN21 claudin 2 71.41(n)
    71.56(a)    		   422292  XM_420271.3  XP_420271.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CLDN26
    		 --
    		 63(a)
    		 1 ↔ 1
    		 GL343376.1(1049574-1050284)
    zebrafish
    (Danio rerio)    		 Actinopterygii cldn26
    		 claudin 2
    		 40(a)
    		 1 ↔ 1
    		 21(36966135-36972763)


    ENSEMBL Gene Tree for CLDN2 (if available)
    TreeFam Gene Tree for CLDN2 (if available) 

    Paralogs
    for CLDN2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN2 gene
    CLDN92  CLDN42  CLDN82  CLDN202  CLDN172  CLDN52  CLDN102  CLDN152  
    CLDN32  CLDN12  CLDN142  CLDN192  CLDN62  CLDN72  
    18 SIMAP similar genes for CLDN2 using alignment to 1 protein entry:     CLD2_HUMAN:
    CLDN7    CLDN3    CLDN14    CLDN9    CLDN4    CLDN6
    CLDN17    CLDN20    CLDN8    CLDN19    CLDN5    CLDN1
    CLDN10    CLDN24    CLDN18    CLDN22    CLDN15    CLDN25

    CLDN2 for paralogs           About GeneDecksing



    Genomic Variants
    for CLDN2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/330 NCBI SNPs in CLDN2 are shown (see all 330)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1823973431,2
    		--106141421(+) CACTTC/TGCCTC 1 -- us2k10--------
    rs59627721,2
    		C,H--106141450(+) TTTTTG/TGGGGG 1 -- us2k1 trp36Minor allele frequency- T:0.07WA NA 15
    rs1429948911,2
    		--106141783(+) CCCCAC/TTTTAC 1 -- us2k10--------
    rs1861254611,2
    		--106142030(+) TCCCAA/GCTAGG 1 -- us2k10--------
    rs1881016371,2
    		--106142095(+) TCATCA/GTTTTG 1 -- us2k10--------
    rs1168176711,2
    		C,--106142244(+) ACCTCC/TTTTGT 1 -- us2k10--------
    rs78897251,2
    		C,F,H,--106142316(+) GTATAG/AGAAAG 1 -- us2k1 trp311Minor allele frequency- A:0.16NS EA NA WA 1370
    rs1853602321,2
    		--106142416(+) GGTGTC/TTGAGC 1 -- us2k10--------
    rs1410696131,2
    		--106142442(+) AATGAA/GAGTTT 1 -- us2k10--------
    rs1905644021,2
    		--106142480(+) TCCAGA/CCAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLDN2 (106143394 - 106174091 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CLDN2
         2 CNVs: 8310 0251
    Locus Specific Mutation Databases (LSDB): CLDN2

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    Disorders / Diseases
    for CLDN2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLDN2 for disorders           About GeneDecksing

    OMIM gene information: 300520    OMIM disorders: --

    20/29 diseases for CLDN2 (see all 29):    About MalaCards
    cervical intraepithelial neoplasia    inflammatory bowel disease    biliary tract cancer    barrett's esophagus
    ulcerative colitis    carcinoid tumors    cholecystitis    hepatitis c
    epididymitis    crohn's disease    adenoiditis    hepatoblastoma
    prostate adenocarcinoma    colon carcinoma    adenocarcinoma    choroiditis
    cervicitis    colon cancer    nasopharyngitis    breast carcinoma

    8 Novoseek disease relationships for CLDN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colitis ulcerative 47.7 5 19538319 (2), 17545772 (2), 16822808 (1)
    inflammatory bowel diseases 38.8 1 18711353 (1)
    adenocarcinoma 22.4 2 18500171 (1), 16505274 (1)
    tumors 11.6 8 18942115 (3), 15619213 (1), 18711353 (1), 19245593 (1) (see all 5)
    carcinoma 11.3 1 18097572 (1)
    inflammation 1.35 1 19214581 (1)
    necrosis 0 2 16822808 (1), 20177070 (1)
    cancer 0 7 18586689 (5), 18500171 (1), 17970035 (1)


    Export disorders for CLDN2 gene to outside databases

    Publications
    for CLDN2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN2 gene, integrated from 9 sources (see all 124):
    (articles sorted by number of sources associating them with CLDN2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. SUMOylation of claudin-2. (PubMed id 22731716)1, 2 Van Itallie C.M....Anderson J.M. (2012)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Cloning of the human claudin-2 5'-flanking region revealed a TATA- less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor- 1alpha. (PubMed id 11934881)1, 2 Sakaguchi T....Reinecker H.-C. (2002)
    8. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (PubMed id 9892664)1, 3 Morita K....Tsukita S. (1999)
    9. Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. (PubMed id 15389642)1, 9 Escaffit F....Beaulieu J.F. (2005)
    10. Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity. (PubMed id 14751232)1, 9 Mankertz J....Schulzke J.D. (2004)

    External Searches for CLDN2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CLDN2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9075 HGNC: 2041 AceView: CLDN2 Ensembl:ENSG00000165376 euGenes: HUgn9075
    ECgene: CLDN2 Kegg: 9075 H-InvDB: CLDN2

    Other Databases showing CLDN2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLDN2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLDN2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLDN2 gene:
    Search GeneIP for patents involving CLDN2

    GeneCards and IP:
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