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Aliases for CLDN2 Gene

Aliases for CLDN2 Gene

  • Claudin 2 2 3
  • SP82 3 4
  • Claudin-2 3

External Ids for CLDN2 Gene

Previous GeneCards Identifiers for CLDN2 Gene

  • GC0XP101455
  • GC0XP103062
  • GC0XP104176
  • GC0XP104915
  • GC0XP105949
  • GC0XP106050
  • GC0XP106163
  • GC0XP095771

Summaries for CLDN2 Gene

Entrez Gene Summary for CLDN2 Gene

  • This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010]

GeneCards Summary for CLDN2 Gene

CLDN2 (Claudin 2) is a Protein Coding gene. Among its related pathways are Integrin Pathway and Cell junction organization. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN9.

UniProtKB/Swiss-Prot for CLDN2 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Wiki entry for CLDN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN2 Gene

Genomics for CLDN2 Gene

Regulatory Elements for CLDN2 Gene

Genomic Location for CLDN2 Gene

106,900,164 bp from pter
106,930,861 bp from pter
30,698 bases
Plus strand

Genomic View for CLDN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLDN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN2 Gene

Proteins for CLDN2 Gene

  • Protein details for CLDN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R6B9

    Protein attributes for CLDN2 Gene

    230 amino acids
    Molecular mass:
    24549 Da
    Quaternary structure:
    • Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).

neXtProt entry for CLDN2 Gene

Proteomics data for CLDN2 Gene at MOPED

Post-translational modifications for CLDN2 Gene

  • The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CLDN2 Gene

Domains for CLDN2 Gene

Gene Families for CLDN2 Gene


Protein Domains for CLDN2 Gene

Suggested Antigen Peptide Sequences for CLDN2 Gene

Graphical View of Domain Structure for InterPro Entry



  • P57739
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN2: view

Function for CLDN2 Gene

Molecular function for CLDN2 Gene

UniProtKB/Swiss-Prot Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN2: view

Phenotypes for CLDN2 Gene

genes like me logo Genes that share phenotypes with CLDN2: view

Animal Models for CLDN2 Gene

MGI Knock Outs for CLDN2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CLDN2 Gene

Localization for CLDN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN2 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CLDN2 Gene COMPARTMENTS Subcellular localization image for CLDN2 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CLDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction ISS --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CLDN2: view

Pathways for CLDN2 Gene

genes like me logo Genes that share pathways with CLDN2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CLDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
genes like me logo Genes that share ontologies with CLDN2: view

Compounds for CLDN2 Gene

(1) HMDB Compounds for CLDN2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(1) Novoseek inferred chemical compound relationships for CLDN2 Gene

Compound -log(P) Hits PubMed IDs
calcium 0 2
genes like me logo Genes that share compounds with CLDN2: view

Transcripts for CLDN2 Gene

Unigene Clusters for CLDN2 Gene

Claudin 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN2 Gene

No ASD Table

Relevant External Links for CLDN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLDN2 Gene

mRNA expression in normal human tissues for CLDN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN2 Gene

This gene is overexpressed in Kidney - Cortex (22.7), Liver (17.0), Small Intestine - Terminal Ileum (5.7), and Pancreas (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLDN2 Gene

SOURCE GeneReport for Unigene cluster for CLDN2 Gene Hs.522746

genes like me logo Genes that share expressions with CLDN2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CLDN2 Gene

Orthologs for CLDN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLDN2 35
  • 91.3 (n)
  • 93.91 (a)
CLDN2 36
  • 94 (a)
(Canis familiaris)
Mammalia CLDN2 35
  • 88.41 (n)
  • 93.48 (a)
CLDN2 36
  • 91 (a)
(Mus musculus)
Mammalia Cldn2 35
  • 87.1 (n)
  • 91.3 (a)
Cldn2 16
Cldn2 36
  • 91 (a)
(Monodelphis domestica)
Mammalia CLDN2 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia CLDN2 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Cldn2 35
  • 88.26 (n)
  • 91.74 (a)
(Gallus gallus)
Aves CLDN2 35
  • 71.26 (n)
  • 71.56 (a)
CLDN2 36
  • 70 (a)
(Anolis carolinensis)
Reptilia CLDN2 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489170 35
  • 63.77 (n)
  • 58.26 (a)
(Danio rerio)
Actinopterygii cldn2 36
  • 41 (a)
Species with no ortholog for CLDN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN2 Gene

Gene Tree for CLDN2 (if available)
Gene Tree for CLDN2 (if available)

Paralogs for CLDN2 Gene

Selected SIMAP similar genes for CLDN2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLDN2: view

Variants for CLDN2 Gene

Sequence variations from dbSNP and Humsavar for CLDN2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1128218 -- 106,929,581(+) aaaaa(A/T)aaaaa utr-variant-3-prime
rs4535876 -- 106,920,437(+) GATTA(A/G)AAATC intron-variant, utr-variant-5-prime
rs4638003 -- 106,910,490(+) atcac(C/T)tgagg intron-variant
rs4826896 -- 106,926,773(+) tgggg(C/G)tgagg intron-variant
rs5916772 -- 106,918,813(+) TTCCA(A/G)GTCTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLDN2 Gene

Variant ID Type Subtype PubMed ID
esv2752312 CNV Gain 17911159
nsv482964 CNV Loss 15286789

Relevant External Links for CLDN2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN2 Gene

Disorders for CLDN2 Gene

(8) Novoseek inferred disease relationships for CLDN2 Gene

Disease -log(P) Hits PubMed IDs
colitis ulcerative 47.7 5
inflammatory bowel diseases 38.8 1
adenocarcinoma 22.4 2
tumors 11.6 7
carcinoma 11.3 1
genes like me logo Genes that share disorders with CLDN2: view

No data available for UniProtKB/Swiss-Prot for CLDN2 Gene

Publications for CLDN2 Gene

  1. Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. (PMID: 15389642) Escaffit F. … Beaulieu J.F. (J. Cell. Physiol. 2005) 3 23
  2. Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas. (PMID: 16328347) Aung P.P. … Yasui W. (Virchows Arch. 2006) 3 23
  3. Transepithelial leak in Barrett's esophagus. (PMID: 17103306) Mullin J.M. … Thornton J.J. (Dig. Dis. Sci. 2006) 3 23
  4. Tight junction proteins in gallbladder epithelium: different expression in acute acalculous and calculous cholecystitis. (PMID: 17283368) Laurila J.J. … Ala-Kokko T.I. (J. Histochem. Cytochem. 2007) 3 23
  5. Distinct claudin expression profile in histologic subtypes of lung cancer. (PMID: 17418912) Moldvay J. … Kiss A. (Lung Cancer 2007) 3 23

Products for CLDN2 Gene

Sources for CLDN2 Gene

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