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CLDN19 Gene

protein-coding   GIFtS: 59
GCID: GC01M043174

Claudin 19

  See CLDN19-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Claudin 191 2
HOMG52 5
claudin-192

External Ids:    HGNC: 20401   Entrez Gene: 1494612   Ensembl: ENSG000001640077   OMIM: 6100365   UniProtKB: Q8N6F13   

Export aliases for CLDN19 gene to outside databases

Previous GC identifers: GC01M042202 GC01M042662 GC01M042612 GC01M042867 GC01M042971 GC01M041318


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLDN19 Gene:
The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific
obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene
are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease
characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis
associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata,
significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been
identified for this gene. (provided by RefSeq, Jun 2010)

GeneCards Summary for CLDN19 Gene:
CLDN19 (claudin 19) is a protein-coding gene. Diseases associated with CLDN19 include hypomagnesemia, renal, with ocular involvement, and chorioretinal scar. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is CLDN4.

UniProtKB/Swiss-Prot: CLD19_HUMAN, Q8N6F1
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLDN19 gene promoter:
         AREB6   AML1a   Sp1   COMP1   HSF2   Olf-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN19 promoter sequence
   Search Chromatin IP Primers for CLDN19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.2

CLDN19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN19 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M043174:  view genomic region     (about GC identifiers)

Start:
43,198,764 bp from pter      End:
43,205,925 bp from pter
Size:
7,162 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CLD19_HUMAN, Q8N6F1 (See protein sequence)
Recommended Name: Claudin-19  
Size: 224 amino acids; 23229 Da
Secondary accessions: B7Z5I2 F5H5P9 Q5QT57 Q8N8X0
Alternative splicing: 3 isoforms:  Q8N6F1-1   Q8N6F1-2   Q8N6F1-3   (No experimental confirmation available. Ref.2 (BAH12918) sequence is in conflict in position: 186:R->C)

Explore the universe of human proteins at neXtProt for CLDN19: NX_Q8N6F1

Explore proteomics data for CLDN19 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLDN19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001116867.1  NP_001172046.1  NP_683763.2  

    ENSEMBL proteins: 
     ENSP00000296387   ENSP00000361617   ENSP00000443229  
    Reactome Protein details: Q8N6F1

    CLDN19 Human Recombinant Protein Products:

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    antibodies-online proteins for CLDN19 (4 products) 

     
    antibodies-online peptides for CLDN19

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    antibodies-online antibodies for CLDN19 (17 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLDN: Claudins

    3 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry Q8N6F1

    ProtoNet protein and cluster: Q8N6F1

    1 Blocks protein domain: IPB006187 Claudin family signature

    UniProtKB/Swiss-Prot: CLD19_HUMAN, Q8N6F1
    Similarity: Belongs to the claudin family


    Find genes that share domains with CLDN19           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD19_HUMAN, Q8N6F1
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0042802identical protein binding ISS--
         
    Find genes that share ontologies with CLDN19           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cldn19):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with CLDN19           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CLDN19: Cldn19tm1Sts Cldn19tm1(KOMP)Vlcg

       genOway: Develop your customized and physiologically relevant rodent model for CLDN19

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    hsa-miR-3690 hsa-miR-4283 hsa-miR-1287 hsa-miR-4311 hsa-miR-328 hsa-miR-185* hsa-miR-492 hsa-miR-4260
    SwitchGear 3'UTR luciferase reporter plasmidCLDN19 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLDN19

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLD19_HUMAN, Q8N6F1: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral component of membrane IEA--
    GO:0016323basolateral plasma membrane IDA16427635

    Find genes that share ontologies with CLDN19           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLDN19 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    5Tight junction
    Tight junction


    Find genes that share SuperPaths with CLDN19           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLDN19
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN19
        Cell adhesion Tight junctions


    1 Reactome Pathway for CLDN19
        Tight junction interactions


    4 Kegg Pathways  (Kegg details for CLDN19):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN19: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CLDN19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLDN19 (Q8N6F12 ENSP000002963874) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLDN16Q9Y5I72, ENSP000002647344MINT-8387845 STRING: ENSP00000264734
    CLDN1ENSP000002955224STRING: ENSP00000295522
    CLDN10ENSP000002993394STRING: ENSP00000299339
    CLDN11ENSP000000647244STRING: ENSP00000064724
    CLDN14ENSP000003392924STRING: ENSP00000339292
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007601visual perception IEA--
    GO:0016338calcium-independent cell-cell adhesion ISS--
    GO:0019227neuronal action potential propagation IEA--
    GO:0043297apical junction assembly IEA--
    GO:0050896response to stimulus IEA--

    Find genes that share ontologies with CLDN19           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLDN19 (CLD19)

    2 HMDB Compounds for CLDN19    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLDN19 gene (3 alternative transcripts): 
    NM_001123395.1  NM_001185117.1  NM_148960.2  

    Unigene Cluster for CLDN19:

    Claudin 19
    Hs.496270  [show with all ESTs]
    Unigene Representative Sequence: NM_001123395
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296387(uc001cht.1) ENST00000372539 ENST00000539749(uc001chu.2 uc010ojv.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CLDN19 (see all 13):
    hsa-miR-3690 hsa-miR-4283 hsa-miR-1287 hsa-miR-4311 hsa-miR-328 hsa-miR-185* hsa-miR-492 hsa-miR-4260
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      QuantiTect SYBR Green Assays in human, mouse, rat CLDN19
      QuantiFast Probe-based Assays in human, mouse, rat CLDN19

    Additional mRNA sequence: 

    AF497644.1 AK056118.1 AK096063.1 AK291197.1 AK298992.1 BC030524.1 

    2 DOTS entries:

    DT.97769386  DT.95179228 

    18 AceView cDNA sequences:

    CD172341 BF431575 CR606681 AK096063 NM_148960 AI245696 CD515178 BI768765 
    BX389517 CA389810 BM681600 CD518176 BX357369 BC030524 BX357370 AK056118 
    BF941184 BQ189592 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLDN19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGCCCCTGC
    CLDN19 Expression
    About this image


    CLDN19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone
    CLDN19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLDN19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.496270
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN19: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN19 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn191 , 5 claudin 191, 5 88.39(n)1
    95.54(a)1
      4 (55.34 cM)5
    2426531  NM_001038590.11  NP_001033679.11 
     1192554145 
    chicken
    (Gallus gallus)
    Aves LOC7692451 claudin-19-like 67.73(n)
    65.75(a)
      769245  XM_003642541.2  XP_003642589.2 
    lizard
    (Anolis carolinensis)
    Reptilia CLDN196
    claudin 19
    77(a)
    1 ↔ 1
    AAWZ02040417(804-2539)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cldn191 claudin 19 70.68(n)
    76.85(a)
      100490546  XM_002937034.2  XP_002937080.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cldn191 claudin 19 68.1(n)
    67.46(a)
      550431  NM_001017736.1  NP_001017736.1 


    ENSEMBL Gene Tree for CLDN19 (if available)
    TreeFam Gene Tree for CLDN19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLDN19 gene
    CLDN42  CLDN92  CLDN82  CLDN202  CLDN172  CLDN52  CLDN22  CLDN12  
    CLDN142  CLDN32  CLDN62  CLDN72  
    18 SIMAP similar genes for CLDN19 using alignment to 1 protein entry:     CLD19_HUMAN:
    CLDN7    CLDN1    CLDN3    CLDN4    CLDN5    CLDN8
    CLDN14    CLDN9    CLDN6    CLDN18    CLDN10    CLDN2
    CLDN20    CLDN17    CLDN15    CLDN11    CLDN24    CLDN22

    Find genes that share paralogs with CLDN19           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLDN19 (see all 213)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0312394
    Hypomagnesemia 5 (HOMG5)4--see VAR_0312392 G D mis40--------
    VAR_0312404
    Hypomagnesemia 5 (HOMG5)4--see VAR_0312402 Q E mis40--------
    VAR_0312414
    Hypomagnesemia 5 (HOMG5)4--see VAR_0312412 L P mis40--------
    rs1136601351,2
    C--43276930(+) TTTTTG/-AGATG 3 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1129527071,2
    C,F--43276952(+) TGTTGC/TCCAGG 3 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1140450621,2
    F--43276992(+) CTGCAG/ACTTTC 3 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1924444581,2
    --43276998(+) CTTTCA/GCCTCC 3 -- ds50010--------
    rs1846595801,2
    --43277036(+) CCTCCC/TGAGTA 3 -- ds50010--------
    rs112107071,2
    C,F,A,H--43277209(+) acgccT/CggctA 3 -- ds500110Minor allele frequency- C:0.38NA WA CSA EA 374
    rs2007630671,2
    --43277235(+) TCTTT-/TCTTTTT 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for CLDN19 (43198764 - 43205925 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CLDN19:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829682CNV Loss17160897

    Human Gene Mutation Database (HGMD): CLDN19
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLDN19
    DNA2.0 Custom Variant and Variant Library Synthesis for CLDN19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610036   
    OMIM disorders: 248190  
    UniProtKB/Swiss-Prot: CLD19_HUMAN, Q8N6F1
  • Hypomagnesemia 5 (HOMG5) [MIM:248190]: A progressive renal disease characterized by primary renal
    magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular
    abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. The
    renal phenotype is virtually undistinguishable from that of patients with HOMG3. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 5 diseases for CLDN19:    
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    hypomagnesemia, renal, with ocular involvement    chorioretinal scar    hypomagnesemia 5, renal, with ocular involvement    nephrocalcinosis
    myopia

    1 disease from the University of Copenhagen DISEASES database for CLDN19:
    Nephrocalcinosis

    Find genes that share disorders with CLDN19           About GenesLikeMe


    Export disorders for CLDN19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLDN19 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with CLDN19)
        Utopia: connect your pdf to the dynamic
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    1. Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. (PubMed id 17033971)1, 2, 9 Konrad M.... Weber S. (Am. J. Hum. Genet. 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease. (PubMed id 16427635)1, 9 Lee N.P....Luk J.M. (FEBS Lett. 2006)
    5. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    6. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC): report of three cases with a novel mutation in CLDN19 gene. (PubMed id 23538362)1 Al-Shibli A....Al Attrach I. (Saudi J Kidney Dis Transpl 2013)
    7. Claudin-19 mutations and clinical phenotype in Spanish patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis. (PubMed id 23301036)1 Claverie-MartA-n F....Muley R. (PLoS ONE 2013)
    8. Hypomagnesemia-hypercalciuria-nephrocalcinosis and ocular findings: a new claudin-19 mutation. (PubMed id 22734304)1 Ekinci Z....Konrad M. (Turk. J. Pediatr. 2012)
    9. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis: phenotype-genotype correlation and outcome in 32 patients with CLDN16 or CLDN19 mutations. (PubMed id 22422540)1 Godron A....Vargas-Poussou R. (Clin J Am Soc Nephrol 2012)
    10. Renal, ocular, and neuromuscular involvements in patients with CLDN19 mutations. (PubMed id 21030577)1 Faguer S....Ribes D. (Clin J Am Soc Nephrol 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 149461 HGNC: 2040 AceView: CLDN19 Ensembl:ENSG00000164007 euGenes: HUgn149461
    ECgene: CLDN19 Kegg: 149461 H-InvDB: CLDN19

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLDN19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLDN19 gene:
    Search GeneIP for patents involving CLDN19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from genOway)
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