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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN18 Gene

protein-coding   GIFtS: 60
GCID: GC03P137717

claudin 18

(Previous name: surfactant associated protein J )
(Previous symbol: SFTPJ)
 Explore 14 diseases affiliated with
CLDN18 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLDN18    

Aliases
for CLDN18 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Claudin 181 2     Claudin-181
SFTPJ1 2     Surfactant Associated 52
Surfactant Associated Protein J1 2     Surfactant, Pulmonary Associated Protein J2
SFTA52     

External Ids:    HGNC: 20391   Entrez Gene: 512082   Ensembl: ENSG000000664057   OMIM: 6092105   UniProtKB: P568563   

Export aliases for CLDN18 gene to outside databases

Previous GC identifers: GC03P134713 GC03P138520 GC03P138999 GC03P139049 GC03P139038 GC03P139200 GC03P135092


Summaries
for CLDN18 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLDN18:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely
through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in
maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and
highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein
kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively
spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: CLD18_HUMAN, P56856
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN18


Genomic Views
for CLDN18 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN18 gene promoter:
         c-Rel   CUTL1   LyF-1   Evi-1   C/EBPalpha   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLDN18 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLDN18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q

CLDN18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN18 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P137717:  view genomic region     (about GC identifiers)

Start:
 137,717,577 bp from pter      End:
 137,752,494 bp from pter
Size:
 34,918 bases      Orientation:
 plus strand

Proteins
for CLDN18 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLD18_HUMAN, P56856 (See protein sequence)
Recommended Name: Claudin-18  
Size: 261 amino acids; 27856 Da
Subcellular location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Secondary accessions: A5PL21 Q96PH4
Alternative splicing: 2 isoforms:  P56856-1   P56856-2   

Explore the universe of human proteins at neXtProt for CLDN18: NX_P56856

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56856

    • CLDN18 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001002026.1  NP_057453.1  

    ENSEMBL proteins: 
     ENSP00000340939   ENSP00000183605   ENSP00000419732  
    Reactome Protein details: P56856
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane IEA--


    CLDN18 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CLDN18 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLDN18 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017974 Claudin_CS
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin
     IPR003928 Claudin18

    Graphical View of Domain Structure for InterPro Entry P56856

    ProtoNet protein and cluster: P56856

    2 Blocks protein families:
    IPB003928 Claudin-18 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD18_HUMAN, P56856
    Similarity: Belongs to the claudin family


    Function
    for CLDN18 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLD18_HUMAN, P56856
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

    miRNA
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    hsa-miR-495 hsa-miR-448 hsa-miR-300 hsa-miR-520d-5p hsa-miR-7-1* hsa-miR-889 hsa-miR-3121-3p hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN18 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN18 (see all 7)
    OriGene shRNA RFP: CLDN18
    OriGene siRNA: CLDN18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN18

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN18 

    Cell Line
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    Search LifeMap BioReagents cell lines for CLDN18

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0042802identical protein binding ISS--


    CLDN18 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CLDN18:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Cldn18tm1Lex for CLDN18
         1 MGI phenotypic allele for Cldn18 (no phenotypes)

    CLDN18 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLDN18 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Tight junction interactions0.49
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99
    3Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Epithelial Tight Junctions0.36
    4Hepatitis C
    		Hepatitis C1.00
    5Leukocyte transendothelial migration
    		Leukocyte transendothelial migration1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CLDN18
        Cell adhesion Tight junctions

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN18
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN18
        Cell adhesion Tight junctions

    4        Reactome Pathways for CLDN18
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN18):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN18 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/26 Interacting proteins for CLDN18 (ENSP000001836054) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLDN12ENSP000002879164STRING: ENSP00000287916
    CLDN14ENSP000003392924STRING: ENSP00000339292
    CLDN15ENSP000003088704STRING: ENSP00000308870
    CLDN17ENSP000002868084STRING: ENSP00000286808
    CLDN20ENSP000003561334STRING: ENSP00000356133
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--
    GO:0034329cell junction assembly TAS--
    GO:0045216cell-cell junction organization TAS--
    GO:0070830tight junction assembly TAS--


    CLDN18 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLDN18 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN18

    1 HMDB Compound for CLDN18    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CLDN18 / CLD18 

    Transcripts
    for CLDN18 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLDN18 gene (2 alternative transcripts): 
    NM_001002026.2  NM_016369.3  

    Unigene Cluster for CLDN18:

    Claudin 18
    Hs.655324  [show with all ESTs]
    Unigene Representative Sequence: BC142708
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343735(uc003ero.1) ENST00000183605(uc003erp.1 uc010hue.1)
    ENST00000479660

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLDN18
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CLDN18 (see all 17):
    hsa-miR-495 hsa-miR-448 hsa-miR-300 hsa-miR-520d-5p hsa-miR-7-1* hsa-miR-889 hsa-miR-3121-3p hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CLDN18 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN18 (see all 7)
    OriGene shRNA RFP: CLDN18
    OriGene siRNA: CLDN18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN18
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN18 (see all 7)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN18

    Additional cDNA sequence: 

    AF221069.1 AF349452.1 AK098474.1 AK298103.1 AY102073.1 AY358479.1 BC142708.1 BC146668.1 

    6 DOTS entries:

    DT.40189945  DT.120894249  DT.91669284  DT.95363359  DT.99999176  DT.100723182 

    24/114 AceView cDNA sequences (see all 114):

    AF221069 BM853992 BM836109 AA663907 BM785703 AY358479 BM786101 BM786125 
    BM837765 AI820565 AA906712 AF349452 BM829570 NM_016369 BM768415 BM851728 
    BM851235 AI821019 AI581308 AY102073 BM788945 NM_001002026 BP340986 CA436153 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CLDN18    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                                
    SP2:        -     -                                 
    SP3:                          -                     


    ECgene alternative splicing isoforms for CLDN18

    Expression
    for CLDN18 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGTTTGTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLDN18 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Alveolar type II cells (Derivation of mature...)Lung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CLDN18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN18

    SOURCE GeneReport for Unigene cluster: Hs.655324

    UniProtKB/Swiss-Prot: CLD18_HUMAN, P56856
    Tissue specificity: Concentrated at the cell-cell borders of epithelial cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN18: 
              Lung Cancer in human mouse rat
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN18
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN18

    Orthologs
    for CLDN18 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN18 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CLDN181 claudin 18 74.19(n)
    76.26(a)    		   429135  XM_003641730.1  XP_003641778.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CLDN186
    		 --
    		 75(a)
    		 1 ↔ 1
    		 3(33101028-33110885)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC687192 hypothetical protein MGC68719 76.66(n)    BC060425.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5572091 similar to claudin-18A2.1 52.34(n)
    36.92(a)    		   557209  XM_002660816.1  XP_002660862.1 


    ENSEMBL Gene Tree for CLDN18 (if available)
    TreeFam Gene Tree for CLDN18 (if available) 

    Paralogs
    for CLDN18 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN18 gene
    CLDN252  CLDN242  CLDN222  
    18 SIMAP similar genes for CLDN18 using alignment to 2 protein entries:     CLD18_HUMAN (see all proteins):
    CLDN19    CLDN7    CLDN10    CLDN1    CLDN3    CLDN15
    CLDN20    CLDN9    CLDN14    CLDN4    CLDN6    CLDN17
    CLDN8    CLDN2    CLDN5    CLDN11    CLDN24    CLDN22

    CLDN18 for paralogs           About GeneDecksing



    Genomic Variants
    for CLDN18 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/536 NCBI SNPs in CLDN18 are shown (see all 536)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1452389801,2
    		--137715826(+) GAATG-/CACACAC 1 -- us2k10--------
    rs1844716001,2
    		--137715853(+) CTAAAC/TGATAT 1 -- us2k10--------
    rs1422673271,2
    		--137715966(+) AGAACA/GCAGAG 1 -- us2k10--------
    rs729911131,2
    		C,--137715982(+) AGCCAA/GCAACA 1 -- us2k12Minor allele frequency- G:0.10WA 120
    rs114082381,2
    		C,--137716065(+) TGGAC-/AAAAAA 1 -- us2k10--------
    rs1160034261,2
    		F,--137716102(+) AGAGAC/TACTTT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1893454941,2
    		--137716244(+) CAGTGA/CTCCAT 1 -- us2k10--------
    rs1812435221,2
    		--137716303(+) CAATCC/GAGAGA 1 -- us2k10--------
    rs1855883231,2
    		--137716575(+) TAACTA/GCTACA 1 -- us2k10--------
    rs1903885031,2
    		--137716598(+) TAACCA/GTGTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLDN18 (137717577 - 137752494 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CLDN18
         2 CNVs: 8991 3449

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    Disorders / Diseases
    for CLDN18 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLDN18 for disorders           About GeneDecksing

    OMIM gene information: 609210    OMIM disorders: --

    14 diseases for CLDN18:    About MalaCards
    ulcerative colitis    signet ring cell adenocarcinoma    adenocarcinoma    barrett's esophagus
    pulmonary edema    intrahepatic cholangiocarcinoma    hepatitis c    gastric cancer
    cholangiocarcinoma    pancreatic cancer    colorectal cancer    pancreatitis
    hepatitis    carcinoma

    1 disease from the University of Copenhagen DISEASES database for CLDN18:
    Pancreatic ductal adenocarcinoma

    1 Novoseek disease relationship for CLDN18 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 57 5 17459057 (2), 19261089 (1), 17249269 (1)


    Export disorders for CLDN18 gene to outside databases

    Publications
    for CLDN18 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN18 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with CLDN18)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. (PubMed id 11585919)1, 2, 9 Niimi T.... Kimura S. (2001)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. New markers of pancreatic cancer identified through differential gene expression analyses: claudin 18 and annexin A8. (PubMed id 18223320)1, 9 Karanjawala Z.E....Hruban R.H. (2008)
    4. Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma. (PubMed id 18580680)1, 9 Sentani K....Yasui W. (2008)
    5. Increased expression of the tight junction molecule claudin-18 A1 in both experimental colitis and ulcerative colitis. (PubMed id 18831034)1, 9 Zwiers A....Bouma G. (2008)
    6. Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development. (PubMed id 19047087)1, 9 Sahin U....Tureci O. (2008)
    7. Transcriptional activation of the human claudin-18 gene promoter through two AP-1 motifs in PMA-stimulated MKN45 gastric cancer cells. (PubMed id 18032479)1, 9 Yano K....Niimi T. (2008)
    8. Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance. (PubMed id 17932229)1, 9 Jovov B....Orlando R.C. (2007)
    9. Gastric and intestinal claudin expression at the invasive front of gastric carcinoma. (PubMed id 17459057)1, 9 Matsuda Y....Yokozaki H. (2007)
    10. Immunohistochemical analysis of claudin expression in pancreatic cystic tumors. (PubMed id 21206985)1 Lee J.H....Park S.W. (2011)

    External Searches for CLDN18 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CLDN18 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51208 HGNC: 2039 AceView: CLDN18 Ensembl:ENSG00000066405 euGenes: HUgn51208
    ECgene: CLDN18 Kegg: 51208 H-InvDB: CLDN18

    Other Databases showing CLDN18 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLDN18 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN18 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLDN18 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLDN18 gene:
    Search GeneIP for patents involving CLDN18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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