Aliases for CLDN18 Gene
External Ids for CLDN18 Gene
Previous HGNC Symbols for CLDN18 Gene
Previous GeneCards Identifiers for CLDN18 Gene
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
GeneCards Summary for CLDN18 Gene
CLDN18 (Claudin 18) is a Protein Coding gene. Diseases associated with CLDN18 include Ulcerative Colitis and Colitis. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN10.
UniProtKB/Swiss-Prot for CLDN18 Gene
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.