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Aliases for CLDN18 Gene

Aliases for CLDN18 Gene

  • Claudin 18 2 3
  • Surfactant Associated Protein J 2 3
  • Surfactant, Pulmonary Associated Protein J 3
  • Surfactant Associated 5 3
  • SFTA5 3
  • SFTPJ 3

External Ids for CLDN18 Gene

Previous HGNC Symbols for CLDN18 Gene

  • SFTPJ

Previous GeneCards Identifiers for CLDN18 Gene

  • GC03P134713
  • GC03P138520
  • GC03P138999
  • GC03P139049
  • GC03P139038
  • GC03P139200
  • GC03P137717
  • GC03P135092

Summaries for CLDN18 Gene

Entrez Gene Summary for CLDN18 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]

GeneCards Summary for CLDN18 Gene

CLDN18 (Claudin 18) is a Protein Coding gene. Diseases associated with CLDN18 include mucinous ovarian cystadenoma and ulcerative colitis. Among its related pathways are Integrin Pathway and Cell junction organization. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN15.

UniProtKB/Swiss-Prot for CLDN18 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Wiki entry for CLDN18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN18 Gene

Genomics for CLDN18 Gene

Regulatory Elements for CLDN18 Gene

Genomic Location for CLDN18 Gene

Chromosome:
3
Start:
137,998,735 bp from pter
End:
138,033,655 bp from pter
Size:
34,921 bases
Orientation:
Plus strand

Genomic View for CLDN18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLDN18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN18 Gene

Proteins for CLDN18 Gene

  • Protein details for CLDN18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56856-CLD18_HUMAN
    Recommended name:
    Claudin-18
    Protein Accession:
    P56856
    Secondary Accessions:
    • A5PL21
    • Q96PH4

    Protein attributes for CLDN18 Gene

    Size:
    261 amino acids
    Molecular mass:
    27856 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLDN18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLDN18 Gene

Proteomics data for CLDN18 Gene at MOPED

Post-translational modifications for CLDN18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN18 Gene

Antibody Products

No data available for DME Specific Peptides for CLDN18 Gene

Domains & Families for CLDN18 Gene

Gene Families for CLDN18 Gene

Protein Domains for CLDN18 Gene

Suggested Antigen Peptide Sequences for CLDN18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56856

UniProtKB/Swiss-Prot:

CLD18_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN18: view

Function for CLDN18 Gene

Molecular function for CLDN18 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN18: view
genes like me logo Genes that share phenotypes with CLDN18: view

Animal Models for CLDN18 Gene

MGI Knock Outs for CLDN18:

Animal Model Products

miRNA for CLDN18 Gene

miRTarBase miRNAs that target CLDN18

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN18

Clone Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CLDN18 Gene

Localization for CLDN18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN18 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDN18 Gene COMPARTMENTS Subcellular localization image for CLDN18 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CLDN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLDN18: view

Pathways & Interactions for CLDN18 Gene

genes like me logo Genes that share pathways with CLDN18: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CLDN18 Gene

Gene Ontology (GO) - Biological Process for CLDN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
GO:0034329 cell junction assembly TAS --
GO:0045216 cell-cell junction organization TAS --
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with CLDN18: view

No data available for SIGNOR curated interactions for CLDN18 Gene

Drugs & Compounds for CLDN18 Gene

(1) Drugs for CLDN18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with CLDN18: view

Transcripts for CLDN18 Gene

Unigene Clusters for CLDN18 Gene

Claudin 18:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN18

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN18 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: - -
SP3: -

Relevant External Links for CLDN18 Gene

GeneLoc Exon Structure for
CLDN18
ECgene alternative splicing isoforms for
CLDN18

Expression for CLDN18 Gene

mRNA expression in normal human tissues for CLDN18 Gene

mRNA differential expression in normal tissues according to GTEx for CLDN18 Gene

This gene is overexpressed in Stomach (x39.9) and Lung (x10.9).

Protein differential expression in normal tissues from HIPED for CLDN18 Gene

This gene is overexpressed in Stomach (40.0), Lung (19.5), and Cardia (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLDN18 Gene



SOURCE GeneReport for Unigene cluster for CLDN18 Gene Hs.655324

mRNA Expression by UniProt/SwissProt for CLDN18 Gene

P56856-CLD18_HUMAN
Tissue specificity: Concentrated at the cell-cell borders of epithelial cells
genes like me logo Genes that share expression patterns with CLDN18: view

Protein tissue co-expression partners for CLDN18 Gene

Primer Products

In Situ Assay Products

Orthologs for CLDN18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLDN18 35
  • 84.93 (n)
  • 83.52 (a)
CLDN18 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLDN18 35
  • 92.85 (n)
  • 94.64 (a)
CLDN18 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cldn18 35
  • 87.87 (n)
  • 90.42 (a)
Cldn18 16
Cldn18 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLDN18 35
  • 99.49 (n)
  • 99.62 (a)
CLDN18 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldn18 35
  • 82.12 (n)
  • 83.52 (a)
oppossum
(Monodelphis domestica)
Mammalia CLDN18 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLDN18 35
  • 74.19 (n)
  • 76.26 (a)
CLDN18 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLDN18 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cldn18 35
  • 71.15 (n)
  • 77.08 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68719 35
zebrafish
(Danio rerio)
Actinopterygii cldn18 35
  • 52.18 (n)
  • 37.38 (a)
CLDN18 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
CSA.10090 36
  • 30 (a)
ManyToMany
Species with no ortholog for CLDN18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN18 Gene

ENSEMBL:
Gene Tree for CLDN18 (if available)
TreeFam:
Gene Tree for CLDN18 (if available)

Paralogs for CLDN18 Gene

Paralogs for CLDN18 Gene

(18) SIMAP similar genes for CLDN18 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLDN18: view

Variants for CLDN18 Gene

Sequence variations from dbSNP and Humsavar for CLDN18 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs329136 -- 138,033,801(-) GGAAC(A/G)ACACC downstream-variant-500B
rs891349 -- 138,014,829(+) ACTTA(A/G)ATAAG intron-variant
rs1141890 -- 138,032,282(+) CAGCC(A/G)GTCAT utr-variant-3-prime
rs2289767 -- 138,010,142(-) GAGGG(A/G)AGCTC intron-variant, upstream-variant-2KB
rs2589258 -- 138,033,162(-) AACTT(C/G)TTATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CLDN18 Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914
nsv877535 CNV Gain 21882294
dgv1511e1 CNV Complex 17122850
nsv460863 CNV Loss 19166990
esv2751978 CNV Loss 17911159
nsv528340 CNV Gain 19592680
dgv1512e1 CNV Complex 17122850

Variation tolerance for CLDN18 Gene

Residual Variation Intolerance Score: 29.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.99; 68.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLDN18 Gene

HapMap Linkage Disequilibrium report
CLDN18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN18 Gene

Disorders for CLDN18 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CLDN18 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mucinous ovarian cystadenoma
  • mucinous cystadenoma of ovary
ulcerative colitis
  • left-sided ulcerative colitis
- elite association

Relevant External Links for CLDN18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLDN18
genes like me logo Genes that share disorders with CLDN18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN18 Gene

Publications for CLDN18 Gene

  1. Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. (PMID: 19706394) Hou J. … Goodenough D.A. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67
  2. Ion transport and barrier function in a telomerase-immortalized human nondysplastic, Barrett's cell line (BAR-T). (PMID: 19673046) Jovov B. … Orlando R.C. (Dis. Esophagus 2009) 23 67
  3. Transcriptome dissection of gastric cancer: identification of novel diagnostic and therapeutic targets from pathology specimens. (PMID: 19261089) Yasui W. … Motoshita J. (Pathol. Int. 2009) 23 67
  4. Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development. (PMID: 19047087) Sahin U. … TA1reci O. (Clin. Cancer Res. 2008) 23 67
  5. New markers of pancreatic cancer identified through differential gene expression analyses: claudin 18 and annexin A8. (PMID: 18223320) Karanjawala Z.E. … Hruban R.H. (Am. J. Surg. Pathol. 2008) 23 67

Products for CLDN18 Gene

Sources for CLDN18 Gene

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