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CLDN18 Gene

protein-coding   GIFtS: 59
GCID: GC03P137717

Claudin 18

(Previous name: surfactant associated protein J)
(Previous symbol: SFTPJ)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Claudin 181 2     claudin-182
SFTPJ1 2     Surfactant Associated 52
Surfactant Associated Protein J1 2     Surfactant, Pulmonary Associated Protein J2
SFTA52     

External Ids:    HGNC: 20391   Entrez Gene: 512082   Ensembl: ENSG000000664057   OMIM: 6092105   UniProtKB: P568563   

Export aliases for CLDN18 gene to outside databases

Previous GC identifers: GC03P134713 GC03P138520 GC03P138999 GC03P139049 GC03P139038 GC03P139200 GC03P135092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLDN18 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative
colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase
C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene
in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
(provided by RefSeq, Jun 2010)

GeneCards Summary for CLDN18 Gene:
CLDN18 (claudin 18) is a protein-coding gene. Diseases associated with CLDN18 include signet ring cell adenocarcinoma, and ulcerative colitis. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is ENSG00000262302.

UniProtKB/Swiss-Prot: CLD18_HUMAN, P56856
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLDN18 gene promoter:
         c-Rel   CUTL1   LyF-1   Evi-1   C/EBPalpha   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN18 promoter sequence
   Search Chromatin IP Primers for CLDN18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q

CLDN18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN18 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P137717:  view genomic region     (about GC identifiers)

Start:
137,717,577 bp from pter      End:
137,752,494 bp from pter
Size:
34,918 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CLD18_HUMAN, P56856 (See protein sequence)
Recommended Name: Claudin-18  
Size: 261 amino acids; 27856 Da
Secondary accessions: A5PL21 Q96PH4
Alternative splicing: 2 isoforms:  P56856-1   P56856-2   

Explore the universe of human proteins at neXtProt for CLDN18: NX_P56856

Explore proteomics data for CLDN18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLDN18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001002026.1  NP_057453.1  

    ENSEMBL proteins: 
     ENSP00000340939   ENSP00000183605   ENSP00000419732  
    Reactome Protein details: P56856

    CLDN18 Human Recombinant Protein Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLDN: Claudins

    4 InterPro protein domains:
     IPR017974 Claudin_CS
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin
     IPR003928 Claudin18

    Graphical View of Domain Structure for InterPro Entry P56856

    ProtoNet protein and cluster: P56856

    2 Blocks protein domains:
    IPB003928 Claudin-18 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD18_HUMAN, P56856
    Similarity: Belongs to the claudin family


    CLDN18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLD18_HUMAN, P56856
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0042802identical protein binding ISS--
         
    CLDN18 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CLDN18:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cldn18):
     cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     skeleton 

    CLDN18 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cldn18tm1Lex for CLDN18

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLDN18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLDN18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLDN18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLDN18

    miRNA
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    Block miRNA regulation of human, mouse, rat CLDN18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLDN18 (see all 17):
    hsa-miR-495 hsa-miR-448 hsa-miR-300 hsa-miR-520d-5p hsa-miR-7-1* hsa-miR-889 hsa-miR-3121-3p hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLDN18 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CLDN18

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    GenScript: all cDNA clones in your preferred vector (see all 2): CLDN18 (NM_016369)
    Sino Biological Human cDNA Clone for CLDN18
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN18

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLD18_HUMAN, P56856: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction ISS--
    GO:0016021integral component of membrane IEA--

    CLDN18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLDN18 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    5Tight junction
    Tight junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLDN18
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for CLDN18
        Cell adhesion Tight junctions


    1 Reactome Pathway for CLDN18
        Tight junction interactions


    4 Kegg Pathways  (Kegg details for CLDN18):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN18 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN18: 
              Lung Cancer in human mouse rat
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CLDN18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLDN18 (ENSP000001836054) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLDN12ENSP000002879164STRING: ENSP00000287916
    CLDN14ENSP000003392924STRING: ENSP00000339292
    CLDN15ENSP000003088704STRING: ENSP00000308870
    CLDN17ENSP000002868084STRING: ENSP00000286808
    CLDN20ENSP000003561334STRING: ENSP00000356133
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--
    GO:0034329cell junction assembly TAS--
    GO:0045216cell-cell junction organization TAS--
    GO:0070830tight junction assembly TAS--

    CLDN18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLDN18 (CLD18)

    1 HMDB Compound for CLDN18    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLDN18 gene (2 alternative transcripts): 
    NM_001002026.2  NM_016369.3  

    Unigene Cluster for CLDN18:

    Claudin 18
    Hs.655324  [show with all ESTs]
    Unigene Representative Sequence: BC142708
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343735(uc003ero.1) ENST00000183605(uc003erp.1 uc010hue.1)
    ENST00000479660
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CLDN18 (see all 17):
    hsa-miR-495 hsa-miR-448 hsa-miR-300 hsa-miR-520d-5p hsa-miR-7-1* hsa-miR-889 hsa-miR-3121-3p hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLDN18 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLDN18
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CLDN18 (NM_016369)
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      QuantiTect SYBR Green Assays in human, mouse, rat CLDN18
      QuantiFast Probe-based Assays in human, mouse, rat CLDN18

    Additional mRNA sequence: 

    AF221069.1 AF349452.1 AK098474.1 AK298103.1 AY102073.1 AY358479.1 BC142708.1 BC146668.1 

    5 DOTS entries:

    DT.40189945  DT.120894249  DT.91669284  DT.99999176  DT.100723182 

    Selected AceView cDNA sequences (see all 114):

    AA906712 BE551219 BM837765 BM853992 BM829570 NM_001002026 AF349452 BM759274 
    BM791457 BM836109 BM851203 BM851235 BM795399 AY102073 BM788945 BM785703 
    AA905215 BM786101 AY358479 AF221069 BM851728 BM786125 NM_016369 BP340986 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CLDN18    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                                
    SP2:        -     -                                 
    SP3:                          -                     


    ECgene alternative splicing isoforms for CLDN18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLDN18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTTTGTTA
    CLDN18 Expression
    About this image


    CLDN18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 3 entries
             stomach 1 ; glandular cells   
             stomach cardiac   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Alveolar type II cells
             Human Pulmonary Alveolar Epithelial Cells (HPAEpiC)   
     
     Epithelial Cells (Uncategorized)
             Human Pulmonary Alveolar Epithelial Cells (HPAEpiC)   
    CLDN18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLDN18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655324

    UniProtKB/Swiss-Prot: CLD18_HUMAN, P56856
    Tissue specificity: Concentrated at the cell-cell borders of epithelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN18: 
              Lung Cancer in human mouse rat
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CLDN18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLDN18
    QuantiTect SYBR Green Assays in human, mouse, rat CLDN18
    QuantiFast Probe-based Assays in human, mouse, rat CLDN18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN18 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn181 , 5 claudin 181, 5 87.87(n)1
    90.42(a)1
      9 (52.00 cM)5
    564921  NM_001194921.11  NP_001181850.11 
     996894615 
    chicken
    (Gallus gallus)
    Aves CLDN181 claudin 18 74.19(n)
    76.26(a)
      429135  XM_003641730.2  XP_003641778.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLDN186
    claudin 18
    75(a)
    1 ↔ 1
    3(33101028-33110958)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687192 hypothetical protein MGC68719 76.66(n)    BC060425.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cldn181 claudin 18 52.18(n)
    37.38(a)
      557209  XM_002660816.2  XP_002660862.1 


    ENSEMBL Gene Tree for CLDN18 (if available)
    TreeFam Gene Tree for CLDN18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLDN18 gene
    ENSG000002623022  CLDN102  CLDN252  CLDN152  CLDN242  CLDN222  
    18 SIMAP similar genes for CLDN18 using alignment to 2 protein entries:     CLD18_HUMAN (see all proteins):
    CLDN19    CLDN7    CLDN10    CLDN1    CLDN3    CLDN15
    CLDN20    CLDN9    CLDN14    CLDN4    CLDN6    CLDN17
    CLDN8    CLDN2    CLDN5    CLDN11    CLDN24    CLDN22

    CLDN18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLDN18 (see all 638)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452389801,2
    C--137715826(+) GAATG-/CACACAC 1 -- us2k10--------
    rs1844716001,2
    --137715853(+) CTAAAC/TGATAT 1 -- us2k10--------
    rs1422673271,2
    --137715966(+) AGAACA/GCAGAG 1 -- us2k10--------
    rs729911131,2
    C,F--137715982(+) AGCCAA/GCAACA 1 -- us2k12Minor allele frequency- G:0.10WA 120
    rs114082381,2
    C--137716066(+) TGGAC-/AAAAAA 1 -- us2k10--------
    rs1160034261,2
    C,F--137716102(+) AGAGAC/TACTTT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1893454941,2
    --137716244(+) CAGTGA/CTCCAT 1 -- us2k10--------
    rs1812435221,2
    --137716303(+) CAATCC/GAGAGA 1 -- us2k10--------
    rs1138075461,2
    C--137716397(+) GCTAGC/TAAGCA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1855883231,2
    --137716575(+) TAACTA/GCTACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLDN18 (137717577 - 137752494 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CLDN18:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2751978CNV Loss17911159
    nsv460863CNV Loss19166990
    nsv528340CNV Gain19592680
    nsv877535CNV Gain21882294
    nsv428422CNV Gain+Loss18775914
    dgv1512e1CNV Complex17122850
    dgv1511e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609210    OMIM disorders: --

    16 diseases for CLDN18:    
    About MalaCards
    signet ring cell adenocarcinoma    ulcerative colitis    adenocarcinoma    pulmonary edema
    barrett's esophagus    pancreatic ductal adenocarcinoma    lung adenocarcinoma    intrahepatic cholangiocarcinoma
    cholangiocarcinoma    endotheliitis    hepatitis c    pancreatitis
    pancreatic cancer    hepatitis    colorectal cancer    lung cancer

    1 disease from the University of Copenhagen DISEASES database for CLDN18:
    Pancreatic ductal adenocarcinoma

    CLDN18 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CLDN18 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 57 5 17459057 (2), 19261089 (1), 17249269 (1)


    Export disorders for CLDN18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLDN18 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with CLDN18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. (PubMed id 11585919)1, 2, 9 Niimi T.... Kimura S. (Mol. Cell. Biol. 2001)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. New markers of pancreatic cancer identified through differential gene expression analyses: claudin 18 and annexin A8. (PubMed id 18223320)1, 9 Karanjawala Z.E....Hruban R.H. (Am. J. Surg. Pathol. 2008)
    4. Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma. (PubMed id 18580680)1, 9 Sentani K....Yasui W. (Am. J. Surg. Pathol. 2008)
    5. Increased expression of the tight junction molecule claudin-18 A1 in both experimental colitis and ulcerative colitis. (PubMed id 18831034)1, 9 Zwiers A....Bouma G. (Inflamm. Bowel Dis. 2008)
    6. Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development. (PubMed id 19047087)1, 9 Sahin U....TA1reci O. (Clin. Cancer Res. 2008)
    7. Transcriptional activation of the human claudin-18 gene promoter through two AP-1 motifs in PMA-stimulated MKN45 gastric cancer cells. (PubMed id 18032479)1, 9 Yano K....Niimi T. (Am. J. Physiol. Gastrointest. Liver Physiol. 2008)
    8. Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance. (PubMed id 17932229)1, 9 Jovov B....Orlando R.C. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007)
    9. Gastric and intestinal claudin expression at the invasive front of gastric carcinoma. (PubMed id 17459057)1, 9 Matsuda Y....Yokozaki H. (Cancer Sci. 2007)
    10. Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms. (PubMed id 23900716)1 WAPll S....TA1reci A.9. (Int. J. Cancer 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51208 HGNC: 2039 AceView: CLDN18 Ensembl:ENSG00000066405 euGenes: HUgn51208
    ECgene: CLDN18 Kegg: 51208 H-InvDB: CLDN18

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLDN18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLDN18 gene:
    Search GeneIP for patents involving CLDN18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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