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CLDN17 Gene

protein-coding   GIFtS: 51
GCID: GC21M031537

Claudin 17

  Search for CLDN17
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Claudin 171 2
Human CLDN17 Gene For Claudin-172 11
claudin-172

External Ids:    HGNC: 20381   Entrez Gene: 262852   Ensembl: ENSG000001562827   UniProtKB: P567503   

Export aliases for CLDN17 gene to outside databases

Previous GC identifers: GC21M028115 GC21M030458 GC21M030460 GC21M016947


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLDN17 Gene:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing
freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles
in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on
chromosome 21q22.11. (provided by RefSeq, Jun 2010)

GeneCards Summary for CLDN17 Gene:
CLDN17 (claudin 17) is a protein-coding gene. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is CLDN4.

UniProtKB/Swiss-Prot: CLD17_HUMAN, P56750
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLDN17 gene promoter:
         Bach1   Nkx3-1   LHX3b/Lhx3b   Nkx3-1 v4   p53   Nkx3-1 v1   Nkx3-1 v2   COMP1   Nkx3-1 v3   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN17 promoter sequence

   Search Chromatin IP Primers for CLDN17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.11
CLDN17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN17 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M031537:   GeneLoc Nature:405,311-319
Start:
31,538,241 bp from pter       17,114,968 bp from centromere
End:
31,538,971 bp from pter 17,115,642 bp from centromere
Size:
731 bases 675 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AJ250712
genomic clones: R463J19


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLD17_HUMAN, P56750 (See protein sequence)
Recommended Name: Claudin-17  
Size: 224 amino acids; 24603 Da
Sequence caution: Sequence=AAQ88461.1; Type=Frameshift; Positions=31;
Secondary accessions: Q3MJB5 Q6UY37

Explore the universe of human proteins at neXtProt for CLDN17: NX_P56750

Explore proteomics data for CLDN17 at MOPED


See CLDN17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_036263.1  
ENSEMBL proteins: 
 ENSP00000286808  
Reactome Protein details: P56750

CLDN17 Human Recombinant Protein Products:

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Search eBioscience for ELISAs for CLDN17 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
CLDN: Claudins

4 InterPro protein domains:
 IPR017974 Claudin_CS
 IPR003556 Claudin14
 IPR006187 Claudin
 IPR004031 PMP22/EMP/MP20/Claudin

Graphical View of Domain Structure for InterPro Entry P56750

ProtoNet protein and cluster: P56750

2 Blocks protein domains:
IPB003556 Claudin-14 signature
IPB006187 Claudin family signature


UniProtKB/Swiss-Prot: CLD17_HUMAN, P56750
Similarity: Belongs to the claudin family


Find genes that share domains with CLDN17           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CLD17_HUMAN, P56750
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

     Genatlas biochemistry entry for CLDN17:
claudin 17,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major
structural components of tight junction (TJ) strands

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005198structural molecule activity IEA--
GO:0042802identical protein binding ISS--
     
Find genes that share ontologies with CLDN17           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLDN17
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLDN17

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLDN17
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLDN17

miRNA
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat CLDN17

Gene Editing
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GenScript: all cDNA clones in your preferred vector: CLDN17 (NM_012131)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN17
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN17

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN17


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CLD17_HUMAN, P56750: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
golgi apparatus5
plasma membrane5

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IDA16780588
GO:0005923tight junction ISS--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with CLDN17           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CLDN17 About   (see all 7)  
See pathways by source

SuperPathContained pathways About
1Cell junction organization
Cell junction organization0.70
Cell-Cell communication0.64
Cell-cell junction organization0.70
Tight junction interactions0.51
2Sertoli-Sertoli Cell Junction Dynamics
Sertoli-Sertoli Cell Junction Dynamics0.38
Epithelial Tight Junctions0.36
3Integrin Pathway
Transendothelial Migration of Leukocytes0.38
4Tight junction
Tight junction
5Leukocyte transendothelial migration
Leukocyte transendothelial migration


Find genes that share SuperPaths with CLDN17           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLDN17
    Sertoli-Sertoli Cell Junction Dynamics
Epithelial Tight Junctions
Transendothelial Migration of Leukocytes

1 Reactome Pathway for CLDN17
    Tight junction interactions


4 Kegg Pathways  (Kegg details for CLDN17):
    Cell adhesion molecules (CAMs)
Tight junction
Leukocyte transendothelial migration
Hepatitis C

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN17: 
          Tight Junctions in human mouse rat
          Cell Junction PathwayFinder in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for CLDN17

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CLDN17 (ENSP000002868084) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
InteractantInteraction Details
GeneCardExternal ID(s)
CLDN12ENSP000002879164STRING: ENSP00000287916
CLDN14ENSP000003392924STRING: ENSP00000339292
CLDN15ENSP000003088704STRING: ENSP00000308870
CLDN18ENSP000001836054STRING: ENSP00000183605
CLDN20ENSP000003561334STRING: ENSP00000356133
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016338calcium-independent cell-cell adhesion ISS--
GO:0034329cell junction assembly TAS--
GO:0045216cell-cell junction organization TAS--
GO:0070830tight junction assembly TAS--

Find genes that share ontologies with CLDN17           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CLDN17 (CLD17)

1 HMDB Compound for CLDN17    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CLDN17 gene: 
NM_012131.2  

Unigene Cluster for CLDN17:

Claudin 17
Hs.258589
Unigene Representative Sequence: AY358094
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000286808(uc011acv.2)
miRNA
Products:
     
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Search for qRT-PCR Assays for microRNAs that regulate CLDN17
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CLDN17
Predesigned siRNA for gene silencing in human, mouse, rat CLDN17
Clone
Products:
     
OriGene clones in human, mouse for CLDN17 (see all 5)
OriGene ORF clones in mouse, rat for CLDN17
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CLDN17 (NM_012131)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLDN17
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN17
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for CLDN17
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLDN17
  QuantiTect SYBR Green Assays in human, mouse, rat CLDN17
  QuantiFast Probe-based Assays in human, mouse, rat CLDN17

Additional mRNA sequence: 

AY358094.1 BC101503.1 BC101505.1 

1 DOTS entry:

DT.91948370 

2 AceView cDNA sequences:

NM_012131 AY358094 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CLDN17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CLDN17 Expression
About this image

CLDN17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CLDN17 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.258589
    Pathway & Disease-focused RT2 Profiler PCR Arrays including CLDN17: 
          Tight Junctions in human mouse rat
          Cell Junction PathwayFinder in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for CLDN17
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLDN17
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QuantiFast Probe-based Assays in human, mouse, rat CLDN17
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN17

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CLDN17 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cldn171 , 5 claudin 171, 5 81.4(n)1
81.7(a)1
  16 (51.12 cM)5
2399311  NM_181490.31  NP_852467.11 
 885058075 
chicken
(Gallus gallus)
Aves CLDN171 claudin 17 58.41(n)
53.81(a)
  427973  XM_425543.2  XP_425543.2 
lizard
(Anolis carolinensis)
Reptilia CLDN176
claudin 17
55(a)
1 ↔ 1
3(146067012-146067602)
zebrafish
(Danio rerio)
Actinopterygii LOC5708421 claudin-9-like 55.79(n)
48.42(a)
  570842  XM_005173789.1  XP_005173846.1 


ENSEMBL Gene Tree for CLDN17 (if available)
TreeFam Gene Tree for CLDN17 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CLDN17 gene
CLDN42  CLDN92  CLDN82  CLDN202  CLDN52  CLDN22  CLDN12  CLDN32  
CLDN142  CLDN62  CLDN72  CLDN192  
18 SIMAP similar genes for CLDN17 using alignment to 1 protein entry:     CLD17_HUMAN:
CLDN8    CLDN4    CLDN6    CLDN3    CLDN7    CLDN9
CLDN1    CLDN2    CLDN5    CLDN19    CLDN18    CLDN24
CLDN14    CLDN20    CLDN10    CLDN22    CLDN25    CLDN15

Find genes that share paralogs with CLDN17           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CLDN17 (see all 97)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1916708921,2
--31537743(+) CATTAA/GATGGA 1 -- ds50010--------
rs1144869731,2
F--31537838(+) TGTTAG/ATATGT 1 -- ds50011Minor allele frequency- A:0.04WA 118
rs1434494091,2
--31537927(+) ATTTCA/GACTTT 1 -- ds50010--------
rs1467621601,2
--31537955(+) TACATC/GATGGT 1 -- ds50010--------
rs1404341451,2
--31537970(+) AAGTAA/GTAAGT 1 -- ds50010--------
rs1503457461,2
--31538042(+) GGAGCA/GGCGAT 1 -- ds50010--------
rs1450287391,2
--31538044(+) AGCAGA/CGATTG 1 -- ds50010--------
rs1489534771,2
--31538145(+) CTTTCA/GTATCA 1 -- ds50010--------
rs570147071,2
C,F--31538153(+) TCAATG/TTAAAT 1 -- ds50016Minor allele frequency- T:0.20WA NA CSA 256
rs1437102081,2
C--31538190(+) TCACAG/TACTTA 1 -- ds50010--------

HapMap Linkage Disequilibrium report for CLDN17 (31538241 - 31538971 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CLDN17:    About this table    
Variant IDTypeSubtypePubMed ID
nsv459235CNV Gain19166990

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CLDN17
DNA2.0 Custom Variant and Variant Library Synthesis for CLDN17

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CLDN17 gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with CLDN17)
    Utopia: connect your pdf to the dynamic
world of online information

  1. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PubMed id 12736707)1, 3, 9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2003)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
  5. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (J. Proteome Res. 2012)
  6. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (PLoS ONE 2010)
  7. The claudins. (PubMed id 19706201)1 Lal-Nag M. and Morin P.J. (Genome Biol. 2009)
  8. Structure and function of claudins. (PubMed id 18036336)1 Krause G....Blasig I.E. (Biochim. Biophys. Acta 2008)
  9. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)1 Hu Y.H....Janitz M. (BMC Genomics 2006)
  10. Tight junction proteins. (PubMed id 12475568)1 GonzA!lez-Mariscal L....Jaramillo B.E. (Prog. Biophys. Mol. Biol. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26285 HGNC: 2038 AceView: CLDN17 Ensembl:ENSG00000156282 euGenes: HUgn26285
ECgene: CLDN17 Kegg: 26285 H-InvDB: CLDN17

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CLDN17 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CLDN17 gene:
Search GeneIP for patents involving CLDN17

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore genomic analysis products

  
 Antibodies for CLDN17 (Claudin-17)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 cDNA Clones for CLDN17 (Claudin-17)   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CLDN17  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CLDN17  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for CLDN17  
 OriGene qSTAR qPCR primer pairs in human, mouse for CLDN17   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for CLDN17   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for CLDN17   OriGene Custom Protein Services for CLDN17  

 
 
 Block miRNA regulation of human, mouse, rat CLDN17 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CLDN17
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLDN17 Predesigned siRNA for gene silencing in human, mouse, rat CLDN17
 QuantiFast Probe-based Assays in human, mouse, rat CLDN17 QuantiTect SYBR Green Assays in human, mouse, rat CLDN17
 PCR Arrays including human, mouse, rat CLDN17 Search Chromatin IP Primers for CLDN17
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLDN17  Search GeneGlobe Interaction Network for CLDN17
 Regulatory tfbs in CLDN17 promoter
 GenScript Custom Purified and Recombinant Proteins Services for CLDN17 GenScript cDNA clones with any tag delivered in your preferred vector for CLDN17
 GenScript Custom Assay Services for CLDN17 GenScript Custom overexpressing Cell Line Services for CLDN17
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for CLDN17 (CLD17)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 CLDN17 antibodies
 CLDN17 proteins
 CLDN17 lysates
 Antibodies for CLDN17
 See all of Abcam's Antibodies, Kits and Proteins for CLDN17
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for CLDN17
 Antibodies for CLDN17
 ELISAs for CLDN17
 CLIAs for CLDN17



 Browse ESI BIO Cell Lines and PureStem Progenitors for CLDN17
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN17
 Browse SwitchGear 3'UTR luciferase reporter plasmids for CLDN17
 SwitchGear Promoter luciferase reporter plasmids for CLDN17
 ThermoFisher Antibodies for CLDN17
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN17
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLDN17
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLDN17
 LSBio Antibodies in human, mouse, rat for CLDN17
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for CLDN17
  Search eBioscience for proteins for CLDN17
  Search eBioscience for elisas for CLDN17
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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