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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLDN17 Gene

protein-coding   GIFtS: 52
GCID: GC21M031537

claudin 17

 Explore 3 diseases affiliated with
CLDN17 via our new
 Human Malady Compendium 
Biological research products
for CLDN17
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Claudin 171 2
Human CLDN17 Gene For Claudin-172 11
MGC1265521
MGC1265541
Claudin-171

External Ids:    HGNC: 20381   Entrez Gene: 262852   Ensembl: ENSG000001562827   UniProtKB: P567503   

Export aliases for CLDN17 gene to outside databases

Previous GC identifers: GC21M028115 GC21M030458 GC21M030460 GC21M016947


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLDN17:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight
junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely
through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in
maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome
21q22.11. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: CLD17_HUMAN, P56750
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN17


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLDN17 gene promoter:
         Bach1   Nkx3-1   LHX3b/Lhx3b   Nkx3-1 v4   p53   Nkx3-1 v1   Nkx3-1 v2   COMP1   Nkx3-1 v3   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLDN17 promoter sequence

   Search SABiosciences Chromatin IP Primers for CLDN17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.11
CLDN17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN17 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M031537:   GeneLoc Nature:405,311-319
Start:
31,538,241 bp from pter       17,114,968 bp from centromere
End:
31,538,971 bp from pter 17,115,642 bp from centromere
Size:
731 bases 675 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AJ250712
genomic clones: R463J19


(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLD17_HUMAN, P56750 (See protein sequence)
Recommended Name: Claudin-17  
Size: 224 amino acids; 24603 Da
Subcellular location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAQ88461.1; Type=Frameshift; Positions=31;
Secondary accessions: Q3MJB5 Q6UY37

Explore the universe of human proteins at neXtProt for CLDN17: NX_P56750

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56750

  • CLDN17 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036263.1  
    ENSEMBL proteins: 
     ENSP00000286808  
    Reactome Protein details: P56750
    Human Recombinant Protein Products: 
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    Novus Biologicals CLDN17 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLDN17

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IDA16780588
    GO:0005886plasma membrane IDA16780588
    GO:0005923tight junction ISS--
    GO:0016021integral to membrane IEA--


    CLDN17 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLDN17


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CLDN17 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017974 Claudin_CS
     IPR003556 Claudin14
     IPR006187 Claudin
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry P56750

    ProtoNet protein and cluster: P56750

    2 Blocks protein families:
    IPB003556 Claudin-14 signature
    IPB006187 Claudin family signature


    UniProtKB/Swiss-Prot: CLD17_HUMAN, P56750
    Similarity: Belongs to the claudin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CLD17_HUMAN, P56750
    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through
    calcium-independent cell-adhesion activity (By similarity)

         Genatlas biochemistry entry for CLDN17:
    claudin 17,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural
    components of tight junction (TJ) strands

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN17

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0042802identical protein binding ISS--


    CLDN17 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    Cell-cell junction organization1.00
    Tight junction interactions0.49
    Cell junction organization0.69
    Cell-Cell communication0.45
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics1.00
    Epithelial Tight Junctions0.36
    3Hepatitis C
    Hepatitis C1.00
    4Leukocyte transendothelial migration
    Leukocyte transendothelial migration1.00
    5Tight junction
    Tight junction1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN17
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    4        Reactome Pathways for CLDN17
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    4         Kegg Pathways  (Kegg details for CLDN17):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Hepatitis C


    CLDN17 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/26 Interacting proteins for CLDN17 (ENSP000002868084) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLDN12ENSP000002879164STRING: ENSP00000287916
    CLDN14ENSP000003392924STRING: ENSP00000339292
    CLDN15ENSP000003088704STRING: ENSP00000308870
    CLDN18ENSP000001836054STRING: ENSP00000183605
    CLDN20ENSP000003561334STRING: ENSP00000356133
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016338calcium-independent cell-cell adhesion ISS--
    GO:0034329cell junction assembly TAS--
    GO:0045216cell-cell junction organization TAS--
    GO:0070830tight junction assembly TAS--


    CLDN17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLDN17

    1 HMDB Compound for CLDN17    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CLDN17 / CLD17 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLDN17 gene: 
    NM_012131.2  

    Unigene Cluster for CLDN17:

    Claudin 17
    Hs.258589
    Unigene Representative Sequence: AY358094
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000286808(uc011acv.2)

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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN17 (see all 7)
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    OriGene siRNA: CLDN17
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN17
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN17
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN17

    Additional cDNA sequence: 

    AY358094.1 BC101503.1 BC101505.1 

    1 DOTS entry:

    DT.91948370 

    2 AceView cDNA sequences:

    NM_012131 AY358094 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLDN17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CLDN17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLDN17

    SOURCE GeneReport for Unigene cluster: Hs.258589
        SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN17: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLDN17 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CLDN171 claudin 17 60.61(n)
    57.22(a)
      427973  XM_425543.2  XP_425543.2 
    lizard
    (Anolis carolinensis)
    Reptilia CLDN176
    --
    55(a)
    1 ↔ 1
    3(146067012-146067602)
    zebrafish
    (Danio rerio)
    Actinopterygii FP102191.16
    zgc:1103336
    (see all 3)
    zgc:110333
    (see all 3)
    40(a)
    29(a)
    (see all 3)
    possible ortholog
    many ↔ many
    (see all 3)
    19(49510163-49510849)
    15(41088756-41103605)


    ENSEMBL Gene Tree for CLDN17 (if available)
    TreeFam Gene Tree for CLDN17 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLDN17 gene
    CLDN92  CLDN42  CLDN82  CLDN202  CLDN52  CLDN22  CLDN102  CLDN152  
    CLDN32  CLDN12  CLDN142  CLDN192  CLDN62  CLDN72  
    18 SIMAP similar genes for CLDN17 using alignment to 1 protein entry:     CLD17_HUMAN:
    CLDN8    CLDN6    CLDN4    CLDN3    CLDN7    CLDN9
    CLDN1    CLDN2    CLDN5    CLDN19    CLDN18    CLDN24
    CLDN14    CLDN20    CLDN10    CLDN22    CLDN25    CLDN15

    CLDN17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/71 NCBI SNPs in CLDN17 are shown (see all 71    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916708921,2
    --31537743(+) CATTAA/GATGGA 1 -- ds50010--------
    rs1144869731,2
    F,--31537838(+) TGTTAG/ATATGT 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1434494091,2
    --31537927(+) ATTTCA/GACTTT 1 -- ds50010--------
    rs1467621601,2
    --31537955(+) TACATC/GATGGT 1 -- ds50010--------
    rs1404341451,2
    --31537970(+) AAGTAA/GTAAGT 1 -- ds50010--------
    rs1503457461,2
    --31538042(+) GGAGCA/GGCGAT 1 -- ds50010--------
    rs1450287391,2
    --31538044(+) AGCAGA/CGATTG 1 -- ds50010--------
    rs1489534771,2
    --31538145(+) CTTTCA/GTATCA 1 -- ds50010--------
    rs570147071,2
    C,F,--31538153(+) TCAATG/TTAAAT 1 -- ds50016Minor allele frequency- T:0.20WA NA CSA 256
    rs1437102081,2
    --31538190(+) TCACAG/TACTTA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CLDN17 (31538241 - 31538971 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLDN17: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CLDN17 for disorders           About GeneDecksing

    3 diseases for CLDN17:    About MalaCards
    hepatitis c    gastric cancer    hepatitis


    Export disorders for CLDN17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLDN17 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with CLDN17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PubMed id 12736707)1, 3, 9 Katoh M. and Katoh M. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    5. Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
    6. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (2010)
    7. The claudins. (PubMed id 19706201)1 Lal-Nag M. and Morin P.J. (2009)
    8. Structure and function of claudins. (PubMed id 18036336)1 Krause G....Blasig I.E. (2008)
    9. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)1 Hu Y.H....Janitz M. (2006)
    10. Tight junction proteins. (PubMed id 12475568)1 Gonzalez-Mariscal L....Jaramillo B.E. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26285 HGNC: 2038 AceView: CLDN17 Ensembl:ENSG00000156282 euGenes: HUgn26285
    ECgene: CLDN17 Kegg: 26285 H-InvDB: CLDN17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLDN17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLDN17 gene:
    Search GeneIP for patents involving CLDN17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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