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Aliases for CLDN17 Gene

Aliases for CLDN17 Gene

  • Claudin 17 2 3

External Ids for CLDN17 Gene

Previous GeneCards Identifiers for CLDN17 Gene

  • GC21M028115
  • GC21M030458
  • GC21M030460
  • GC21M031537
  • GC21M016947

Summaries for CLDN17 Gene

Entrez Gene Summary for CLDN17 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010]

GeneCards Summary for CLDN17 Gene

CLDN17 (Claudin 17) is a Protein Coding gene. Among its related pathways are Integrin Pathway and Cell junction organization. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN9.

UniProtKB/Swiss-Prot for CLDN17 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Wiki entry for CLDN17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN17 Gene

Genomics for CLDN17 Gene

Regulatory Elements for CLDN17 Gene

Genomic Location for CLDN17 Gene

Chromosome:
21
Start:
30,165,564 bp from pter
End:
30,166,756 bp from pter
Size:
1,193 bases
Orientation:
Minus strand

Genomic View for CLDN17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for CLDN17 Gene

Proteins for CLDN17 Gene

  • Protein details for CLDN17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56750-CLD17_HUMAN
    Recommended name:
    Claudin-17
    Protein Accession:
    P56750
    Secondary Accessions:
    • Q3MJB5
    • Q6UY37

    Protein attributes for CLDN17 Gene

    Size:
    224 amino acids
    Molecular mass:
    24603 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88461.1; Type=Frameshift; Positions=31; Evidence={ECO:0000305};

neXtProt entry for CLDN17 Gene

Proteomics data for CLDN17 Gene at MOPED

Post-translational modifications for CLDN17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CLDN17 Gene

Domains & Families for CLDN17 Gene

Gene Families for CLDN17 Gene

Protein Domains for CLDN17 Gene

Suggested Antigen Peptide Sequences for CLDN17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56750

UniProtKB/Swiss-Prot:

CLD17_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN17: view

Function for CLDN17 Gene

Molecular function for CLDN17 Gene

GENATLAS Biochemistry:
claudin 17,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands
UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN17: view

Phenotypes for CLDN17 Gene

GenomeRNAi human phenotypes for CLDN17:
genes like me logo Genes that share phenotypes with CLDN17: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN17

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN17 Gene

Localization for CLDN17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN17 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLDN17 Gene COMPARTMENTS Subcellular localization image for CLDN17 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CLDN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 16780588
GO:0005923 bicellular tight junction ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLDN17: view

Pathways & Interactions for CLDN17 Gene

genes like me logo Genes that share pathways with CLDN17: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CLDN17 Gene

Gene Ontology (GO) - Biological Process for CLDN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
GO:0034329 cell junction assembly TAS --
GO:0045216 cell-cell junction organization TAS --
GO:0070830 bicellular tight junction assembly TAS --
genes like me logo Genes that share ontologies with CLDN17: view

No data available for SIGNOR curated interactions for CLDN17 Gene

Drugs & Compounds for CLDN17 Gene

(1) Drugs for CLDN17 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with CLDN17: view

Transcripts for CLDN17 Gene

mRNA/cDNA for CLDN17 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLDN17

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN17 Gene

No ASD Table

Relevant External Links for CLDN17 Gene

GeneLoc Exon Structure for
CLDN17
ECgene alternative splicing isoforms for
CLDN17

Expression for CLDN17 Gene

mRNA expression in normal human tissues for CLDN17 Gene

mRNA differential expression in normal tissues according to GTEx for CLDN17 Gene

This gene is overexpressed in Vagina (x22.0), Esophagus - Mucosa (x16.5), Cervix - Ectocervix (x7.6), and Minor Salivary Gland (x4.4).

SOURCE GeneReport for Unigene cluster for CLDN17 Gene Hs.258589

genes like me logo Genes that share expression patterns with CLDN17: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CLDN17 Gene

Orthologs for CLDN17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLDN17 35
  • 82.14 (n)
  • 79.02 (a)
CLDN17 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLDN17 35
  • 89.88 (n)
  • 91.07 (a)
CLDN17 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cldn17 35
  • 81.4 (n)
  • 81.7 (a)
Cldn17 16
Cldn17 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLDN17 35
  • 99.11 (n)
  • 98.66 (a)
CLDN17 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldn17 35
  • 80.21 (n)
  • 79.46 (a)
oppossum
(Monodelphis domestica)
Mammalia CLDN17 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLDN17 35
  • 58.41 (n)
  • 53.81 (a)
lizard
(Anolis carolinensis)
Reptilia CLDN17 36
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC570842 35
  • 55.79 (n)
  • 48.42 (a)
CLDN17 36
  • 27 (a)
OneToMany
Species with no ortholog for CLDN17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN17 Gene

ENSEMBL:
Gene Tree for CLDN17 (if available)
TreeFam:
Gene Tree for CLDN17 (if available)

Paralogs for CLDN17 Gene

Paralogs for CLDN17 Gene

(18) SIMAP similar genes for CLDN17 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLDN17: view

Variants for CLDN17 Gene

Sequence variations from dbSNP and Humsavar for CLDN17 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
VAR_033774 -

Structural Variations from Database of Genomic Variants (DGV) for CLDN17 Gene

Variant ID Type Subtype PubMed ID
nsv459235 CNV Gain 19166990

Variation tolerance for CLDN17 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.21; 80.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLDN17 Gene

HapMap Linkage Disequilibrium report
CLDN17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN17 Gene

Disorders for CLDN17 Gene

Relevant External Links for CLDN17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLDN17
genes like me logo Genes that share disorders with CLDN17: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDN17 Gene

Publications for CLDN17 Gene

  1. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PMID: 12736707) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 23 67
  2. The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues. (PMID: 24325792) Man G. … Guanjun W. (Diagn Pathol 2013) 67
  3. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z. … Gao Y. (J. Proteome Res. 2012) 67
  4. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 67
  5. The claudins. (PMID: 19706201) Lal-Nag M. … Morin P.J. (Genome Biol. 2009) 67

Products for CLDN17 Gene

Sources for CLDN17 Gene

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