CLDN17 Gene
protein-coding GIFtS: 52
GCID: GC21M031537
|
|
claudin 17
| |
Aliases for CLDN17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb, and/or 11Nature:405,311-319 and CroW21) About This Section
|
| Aliases |
|---|
| Claudin 171 2 | | Human CLDN17 Gene For Claudin-172 11 | | MGC1265521 | | MGC1265541 | | Claudin-171 |
Export aliases for CLDN17 gene to outside databasesPrevious GC identifers: GC21M028115 GC21M030458 GC21M030460 GC21M016947 |
Summaries for CLDN17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for CLDN17: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tightjunction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freelythrough the paracellular space between epithelial or endothelial cell sheets, and also play critical roles inmaintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome21q22.11. (provided by RefSeq, Jun 2010) UniProtKB/Swiss-Prot: CLD17_HUMAN, P56750Function: Plays a major role in tight junction-specific obliteration of the intercellular space, throughcalcium-independent cell-adhesion activity (By similarity) Gene Wiki entry for CLDN17
|
Genomic Views for CLDN17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics, Whole Chromsome Sequence According to
Nature (Cited Here with Permission):405,311-319 and CroW21) About This Section
|
| GC21M031537: |
GeneLoc |
Nature:405,311-319 |
Start:
|
31,538,241 bp from pter |
17,114,968 bp from centromere |
End:
|
31,538,971 bp from pter |
17,115,642 bp from centromere |
Size:
|
731 bases |
675 bases |
Orientation:
|
minus strand |
minus strand |
| Whole chromosome sequencing: |
| cDNA sequence: |
AJ250712 | | genomic clones: |
R463J19 |
Proteins for CLDN17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: CLD17_HUMAN, P56750 (See
protein sequence)Recommended Name: Claudin-17 Size: 224 amino acids; 24603 Da
Subcellular location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAQ88461.1; Type=Frameshift; Positions=31;
Secondary accessions: Q3MJB5 Q6UY37Explore the universe of human proteins at neXtProt for CLDN17: NX_P56750
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P56750 CLDN17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036263.1 ENSEMBL proteins: ENSP00000286808 Reactome Protein details: P56750 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CLDN17 for ontologies About GeneDecksing
CLDN17 Antibody Products: Assay Products for CLDN17: |
Protein
Domains / Families for CLDN17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLDN17 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P56750ProtoNet protein and cluster: P56750 2 Blocks protein families: IPB003556 Claudin-14 signature IPB006187 Claudin family signature
UniProtKB/Swiss-Prot: CLD17_HUMAN, P56750Similarity: Belongs to the claudin family |
Function for CLDN17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: CLD17_HUMAN, P56750Function: Plays a major role in tight junction-specific obliteration of the intercellular space, throughcalcium-independent cell-adhesion activity (By similarity) Genatlas biochemistry entry for CLDN17:claudin 17,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structuralcomponents of tight junction (TJ) strands
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN17 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN17 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CLDN17 (NM_012131) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLDN17 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN17  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN17 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- | | GO:0042802 | identical protein binding |
ISS | -- |
CLDN17 for ontologies About GeneDecksing
|
Pathways & Interactions for CLDN17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell-cell junction organization | | | 2 | Sertoli-Sertoli Cell Junction Dynamics | | | 3 | Hepatitis C | | | 4 | Leukocyte transendothelial migration | | | 5 | Tight junction | |
Pathway sources See GeneCards unified pathways Show all pathways
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLDN17 4
Reactome Pathways for CLDN17
4
Kegg Pathways (Kegg details for CLDN17):
CLDN17 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLDN17
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/26 Interacting proteins for CLDN17 (ENSP000002868084) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016338 | calcium-independent cell-cell adhesion |
ISS | -- | | GO:0034329 | cell junction assembly |
TAS | -- | | GO:0045216 | cell-cell junction organization |
TAS | -- | | GO:0070830 | tight junction assembly |
TAS | -- |
CLDN17 for ontologies About GeneDecksing
|
Drugs & Compounds for CLDN17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for CLDN17
1 HMDB Compound for CLDN17 About this table Search CenterWatch for drugs/clinical trials and news about CLDN17 / CLD17 
|
Transcripts for CLDN17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for CLDN17 gene: NM_012131.2 Unigene Cluster for CLDN17: Claudin 17 Hs.258589 Unigene Representative Sequence: AY3580941 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000286808(uc011acv.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN17 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN17 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CLDN17 (NM_012131) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLDN17 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN17  |
Additional cDNA sequence: AY358094.1 BC101503.1 BC101505.1 1 DOTS entry: DT.91948370 2 AceView cDNA sequences: NM_012131 AY358094 GeneLoc Exon Structure
|
Expression for CLDN17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLDN17 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See CLDN17 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CLDN17
SOURCE GeneReport for Unigene cluster: Hs.258589 SABiosciences Expression via Pathway-Focused PCR Arrays including CLDN17:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN17 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLDN17 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN17 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN17 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN17 |
Orthologs for CLDN17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CLDN17 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for CLDN17 (if available) TreeFam Gene Tree for CLDN17 (if available)  |
Paralogs for CLDN17 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for CLDN17 gene
- CLDN92 CLDN42 CLDN82 CLDN202 CLDN52 CLDN22 CLDN102 CLDN152
- CLDN32 CLDN12 CLDN142 CLDN192 CLDN62 CLDN72
18 SIMAP similar genes for CLDN17 using alignment to 1 protein entry: CLD17_HUMAN:CLDN8 CLDN6 CLDN4 CLDN3 CLDN7 CLDN9 CLDN1 CLDN2 CLDN5 CLDN19 CLDN18 CLDN24 CLDN14 CLDN20 CLDN10 CLDN22 CLDN25 CLDN15
CLDN17 for paralogs About GeneDecksing
|
Genomic Variants for CLDN17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 21 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for CLDN17 (31538241 - 31538971 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CLDN17: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN17 |
|
Disorders
/ Diseases for CLDN17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLDN17 for disorders About GeneDecksing
3 diseases for CLDN17: About MalaCardshepatitis c gastric cancer hepatitis Export disorders for CLDN17 gene to outside databases
|
Publications for CLDN17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLDN17 gene, integrated from 9 sources (see all 17): (articles sorted by number of sources associating them with CLDN17) | |  | Utopia: connect your pdf to the dynamic world of online information |
- CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PubMed id 12736707)1, 3, 9 Katoh M. and Katoh M. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
- Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
- Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (2010)
- The claudins. (PubMed id 19706201)1 Lal-Nag M. and Morin P.J. (2009)
- Structure and function of claudins. (PubMed id 18036336)1 Krause G....Blasig I.E. (2008)
- Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)1 Hu Y.H....Janitz M. (2006)
- Tight junction proteins. (PubMed id 12475568)1 Gonzalez-Mariscal L....Jaramillo B.E. (2003)
|
External Searches for CLDN17 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CLDN17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLDN17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLDN17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for CLDN17 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CLDN17 gene: Search GeneIP for patents involving CLDN17
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for CLDN17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for CLDN17 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLDN17 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLDN17 | | OriGene Protein Over-expression Lysate for CLDN17 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for CLDN17 | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN17 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLDN17 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for CLDN17 | | OriGene Custom Protein Services for CLDN17 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLDN17 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLDN17 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLDN17 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLDN17 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLDN17 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLDN17 |
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 |  |  |  | |
| | | Search Tocris compounds for CLDN17 |
| |  |  |  |  | | | | |
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 | | CLDN17 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLDN17 |
|  |  |  | | | ThermoFisher Antibodies for CLDN17 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLDN17 |
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Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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